The Anatomy of the Brachial Plexus As Displayed by Magnetic Resonance Imaging: Technique and Application
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THE ANATOMY OF THE BRACHIAL PLEXUS AS DISPLAYED BY MAGNETIC RESONANCE IMAGING: TECHNIQUE AND APPLICATION James D. Collins, MD, Anthony C. Disher, MD, and Theodore Q. Miller, MD Los Angeles, California Full field of view coronal chest magnetic magnetic resonance angiography (MRA) se- resonance imaging (MRI) routinely displays quences were obtained in selected patients. bilateral images of the brachial plexus, surface Coronal, transverse, and sagittal sequences anatomy, and anatomic structures. Eighty pa- were reformatted for evaluation. Saline water tients had chest radiographs correlated with bags were placed between the neck and thorax surgery for thoracic outlet syndrome. The PA to enhance the signal-to-noise ratio. Compro- chest film findings correlated with the surgical mising abnormalities of the brachial plexus findings: smaller thoracic inlet on the concave were confirmed at surgery. Compromise of the side of the cervicothoracic spine scoliosis, neurovascular supply seemed to be one etiol- shorter distance between the dorsal spine of ogy that could be demonstrated. The clinical the second or third thoracic vertebral body to history, technique, and anatomic bilateral bra- the concavity of the first ribs, asymmetric chial plexus imaging is stressed to improve clavicles and coracoid processes, synchon- patient care. The cervical rib is one of the drosis of the first and second ribs, and muscle compromising brachial plexopathies selected atrophy on the side of the clinical complaints. for this presentation. (J Nat! Med Assoc. More than 235 patients were imaged. One 1 995;87:489-498.) hundred sixty-five of these were imaged with a 1.5-T unit and 3-D reconstruction MRI. Coronal, Key words * anatomy * brachial plexopathy transverse (axial), oblique transverse, and sag- * nerve model * MRI * pathology ittal plane Ti-weighted, selected T2-weighted, * 3-D color reconstruction and fast spine echo pulse sequences were obtained, 4- to 5-mm slice thickness, 40 to 45 Conventional roentgenography, linear tomography, cm full field of view, 512x256 matrix and 2 computerized tomography (CT), and magnetic reso- NEX. Two-dimensional time of flight (2D TOF), nance imaging (MRI) are radiographic modalities used to image the thorax, shoulder girdle, and soft tissues. I Vascular structures, surface anatomy, and From the Department of Radiological Sciences, UCLA School the soft tissues are incompletely imaged by conven- of Medicine, and the Department of Radiology, Charles R. Drew Postgraduate School of Medicine, Los Angeles, California. tional radiographic techniques. Computerized to- Presented at the 10th Annual Meeting of the American mography extends the capabilities of radiographic Association of Clinical Anatomists, June 17, 1993, Seattle, imaging to obtain detailed transverse (axial) ana- Washington; the 98th Annual Convention and Scientific Assem- bly of the National Medical Association, August 9, 1993, San tomic sections but CT does not definitively separate Antonio, Texas; and the Sunderland Society, September 22, tumors from vascular and neurovascular structures. 1993, Seattle, Washington. Address reprint requests to Dr tomography reconstructed imaging of James D. Collins, UCLA School of Medicine, Dept of Radiologi- Computed cal Sciences, 10833 Le Conte Ave, Los Angeles, CA 90024- soft-tissue anatomy is not satisfactory, and detailed 1721. peripheral nerve imaging is not possible. Magnetic JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, VOL. 87, NO. 7 489 BRACHIAL PLEXUS The brachial plexus lies within the fascial planes of the neck and axilla, but is routinely displayed on MRI of the thorax and shoulder girdle.' Magnetic resonance multiplane imaging in the supine position allows bilateral sequential imaging of the thorax and the brachial plexus. This is the feature that gave us the opportunity to image the brachial plexus anatomy. construct 3-D color images, and present the anatomy and compromising abnormalities of the brachial plexus as displayed by MRI.2'7 Compromising abnormalities of the brachial plexus and brachial plexopathies result from disorders of the cervicothoracic levels of the vertebral column, the first rib, vascular supply, and soft tissues.8,9 The anterior and middle scalene muscles, through which the brachial plexus nerve roots pass and adhere to the subclavian artery, arise from the cervicothoracic levels of the me vertebral column. The muscles insert and, in part, support the first ribs. The first ribs are curved, flat, and slope obliquely to form most of the thoracic inlet. The slope that gives an anterosuperior directed upper surface changes with respiration and cervicothoracic spine scoliosis, and affects structures crossing the rib. The anterior scalene muscle and the posterior insertion of middle scalene muscle and the first ribs form the scalene triangle. The change in the slope of the first rib Figure 1. Cadaver dissection demonstrating the "M" or "W" of affects the interscalene triangle contents.2'5 The scalene the left brachial plexus. Legend: lateral cord (2 bar white are an arrows), brachial artery (BrA), median nerve (Me), musculo- muscles important visual anatomic landmark in cutaneous nerve (Mu), ulnar nerve (Ul), medial branch of the the understanding of brachial plexopathy displayed by lateral cord of Mu (black single bar arrow), and lateral branch of MRI. the medial cord forming the median nerve (Me). The upper nerve roots of the brachial plexus descend along the margin of the middle scalene muscle and join resonance imaging separates proton densities within the lower nerve roots to envelope the subclavian artery. organ systems and does not require reconstruction or The nerve roots bind to the artery within the scalene repositioning of the patient. The multi-planer MRI triangle to form a neurovascular bundle.'0 This bundle displays the anatomy of the brachial plexus and passes with sympathetic fibers unprotected over the peripheral nerves for investigation by sequential first rib through the scalene triangle, beneath the imaging of landmark anatomy according to proton clavicle and subclavius muscle, inferior to the coracoid density distribution.2 process and posterior to the tendon of the pectoralis The anatomy of the brachial plexus and peripheral minor muscle into the axilla. nerves are graphically displayed in classical text- The subclavian artery, similar to the artery within the books.3'4 Anatomic and clinicopathologic nerve studies femoral triangle, is unprotected4'8 but is not routinely allow investigative radiological studies using MRI to go cannulated for vascular studies. Different from the beyond textbook descriptions.5'6 Bilateral brachial femoral artery, a muscle (the anterior scalene muscle) plexus and peripheral nerve 3-D reconstruction imaging separates the subclavian vein from the subclavian makes possible demonstration of the relationship of artery. This makes the anterior scalene muscle an nerves to their surrounding landmark anatomy (Figure important anatomic landmark in determining compres- 1). The knowledge of peripheral nerve and brachial sion (effacement) of the scalene triangle contents. plexus anatomic imaging offers new avenues for Enlargements of the anterior scalene muscle or atrophy teaching medical students, residents, and health profes- of the anterior scalene muscle increases or decreases the sionals. I distance between the subclavian artery and the sub- 490 JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, VOL. 87, NO. 7 BRACHIAL PLEXUS clavian vein as demonstrated on transverse MRI The signal-to-noise ratio decreases with FSE imag- sequences.2 This distance may be measured on the first ing, causing decreased contrast and resolution of the image or raw data of the magnetic resonance angiogra- images. The low-signal intensities of flowing blood and phy (MRA) 2-D time of flight (TOF) of the brachial the high-signal intensities of myelin combine to vary plexus.' the high signal intensity of nerves. The signal intensity A thin layer of deep fascia envelopes the neurovascu- of nerves then may depend on the imaging axis of that lar bundle of the upper limb. Four spaces are formed nerve.' The combination of a rich blood supply to the from the root of the neck to the lower part of the axilla. spinal cord and cerebral spinal fluid results in the The spaces that may have clinical problems that intermediate-signal intensity of the spinal cord. Nerve compromise the brachial plexus8 include the interverte- roots may have high-signal intensities after they exit bral foramina, scalene triangle, costoclavicular, costo- from the subarachnoid space. The low-signal intensity coracoid, and the axilla. In most individuals, the fascial vertical bands of nutrient vessels may interrupt the plane spacing between soft tissues and osseous struc- high-signal intensity of nerves.2,10,14.15 Compression tures is adequate to perform routine functions without injuries of nerves involve an ischemic component and compromising the nerves and the artery that combine to alter blood supply. Ischemia initiates inflammatory form the neurovascular bundle. Pathology involving changes causing edema and fibrosis. Inflammation and peripheral nerves alters fascial planes. Acute or perma- edema diminishes the signal intensity of nerves and nent changes may alter the adjacent tissues, thereby alters their architecture when compromised in autoim- compromising the vascular supply that nourishes the mune disease.12 peripheral nerves.2 5 6 This results in patients presenting Bilateral imaging of the brachial plexus