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Syllabus 50Yearsofprogressive Course Syllabus Table of Contents Course Description and Disclaimer..................................................................................................Page 2 Venue and Accreditation Information..……………………………………………………………Page 3 Faculty Listing and Industry Disclosures.…………………………………………………………Page 4 Agenda Friday, October 10 ………………………………………………………………...……..Page 7 Agenda Saturday, October 11……………………………………………………………………..Page 8 Lecture Material…………………………………………………………………….……..…….. Page 9 The Milestones of PSP Research (9) Richardson’s syndrome (12) Other Clinical Presentations (15) How to Test Ocular Movements in PSP (17) Neuroradiological Pearls to Identify PSP (25) Symptomatic Approach (26) Palliative care in PSP (34) The Physiology of Tau in Humans (36) Pathophysiology of Tau Accumulation (37) Animal Models of PSP (48) CSF Biomarkers (59) Update on Neuropathology (62) Review on Clinical Trials (63) Future Therapeutic Options (64) Cognitive Changes in PSP – How to best identify them? (65) Early and Late Behavioral Changes in PSP (66) PSP and CBD: One Disease or Two? (67) PSP-look-alikes (68) Is Neurogenetics a Useful Research and Diagnostic Tool? (71) Neurophysiology and PSP: Recent Advances (84) Health Related Quality of Life in Patients with PSP (97) NINDS-SPSP criteria: Why do we need to update them? (99) 50 Years of Progressive Supranuclear Palsy Munich, Germany | October 10-11, 2014 Course Description Despite that research on PSP and related disorders has recently improved at all levels - molecular, brain circuitry, epidemiological and clinical - there has not been a single MDS-sponsored meeting about this devastating disorder. This course is intended to fill this gap, combining an update of the current understanding of PSP and a basic teaching course for those entering into this field. The most active researchers in the field of PSP from Europe will be invited to share their current knowledge and to discuss future research with the audience. Learning Objectives At the conclusion of this activity, you should be able to: Identify features of classical and atypical PSP Describe the pros and cons of available diagnostic criteria for PSP Understand and discuss current research on novel pharmacological and non-pharmacological disease-modifying therapies for PSP Discuss recent advances in neuroimaging and CSF biomarkers to aid in differential diagnosis of PSP and other similar disorders Recognize and discuss potential ways to improve multidisciplinary care of PSP Recommended Audience This course is intended for general medical practitioners, neurology residents, specialist nurse practitioners and other paramedical equivalents in related fields with a working knowledge of diagnosis and general management of this condition. Evaluations Please take time to complete the evaluation form provided at this course. Your input and comments are essential in planning future educational programs for MDS. When completed, evaluations may be returned to the registration desk or the MDS International Secretariat. Educational Disclaimer The primary purpose of MDS programming is to provide educational opportunities that enhance patient care. Information presented, as well as publications, technologies, products and/or services discussed are intended to inform attendees about the knowledge, techniques and experiences of physicians who are willing to share such information with colleagues. A diversity of opinions exists in the medical field, and the views of the course’s faculty are offered solely for educational purposes. Faculty members’ views do not represent those of MDS and do not constitute endorsement by MDS. MDS disclaims any and all liability for all claims which may result from the use of information, publications, products and/or services discussed at this program. Recordings Prohibited Audio and videotaping are not allowed during the course. Photography is also not allowed during the activity. 2 50 Years of Progressive Supranuclear Palsy Munich, Germany | October 10-11, 2014 Course Venue Johannissaal Hall in the Nymphenburg Palace in Munich Schloss Nymphenburg 1 80638 München, Germany EACCME Accreditation The course 50 Years of Progressive Supranuclear Palsy is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the European Union of Medical Specialists (UEMS), www.uems.net. The course 50 Years of Progressive Supranuclear Palsy is designated for a maximum of 9 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. Through an agreement between the European Union of Medical Specialists and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits™. Information on the process to convert EACCME credit to AMA credit can be found at www.ama-assn.org/go/internationalcme. Live educational activities, occurring outside of Canada, recognized by the UEMS-EACCME for ECMEC credits are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of The Royal College of Physicians and Surgeons of Canada. EACCME credits Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. The EACCME credit system is based on 1 ECMEC per hour with a maximum of 3 ECMECs for half a day and 6 ECMECs for a full- day event. Visit the 50 Years of Progressive Supranuclear Palsy webpage following the course in order to print your course certificate and your EACCME certificate. International Parkinson and Movement Disorder Society – European Section MDS International Secretariat 555 East Wells Street, Suite 1100 ● Milwaukee, WI 53202 USA Email: [email protected] Phone: +1 (414) 276-2145 ● Fax : +1 (414) 276-3349 3 50 Years of Progressive Supranuclear Palsy Munich, Germany | October 10-11, 2014 Course Directors Carlo Colosimo, MD Sapienza University of Rome, Italy Carlo Colosimo has served as a consultant and advisory board member for Allergan, Ipsen, Merz and UCB; has received grant/research support from Ipsen; and receives royalties from CIC Edizioni Internazionali Publishers and Cambridge University Press. Günter Höglinger, MD Technical University Munich (TUM) German Center for Neurodegenerative Diseases e.V. (DZ NE) Munich, Germany Günter Höglinger has served as a consultant for UCB, BMS and Sellas; has received grant/research support from UCB; and has received honoraria from UCB and Teva. Course Faculty Angelo Antonini, MD, PhD Institute of Neurology, IRCCS San Camillo, Venice, Italy Angelo Antonini has served as a consultant for UCB and AbbVie; has received grant/research support from Italian Research Health Ministry, Neureca Foundation and Gossweiler Foundation; and received honoraria from UCB, AbbVie, Novartis and GSK. Thomas Arzberger, MD Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich Department of Psychiatry, Ludwig-Maximilians-University Munich German Centre for Neurodegenerative Diseases (DZ NE) Munich Thomas Arzberger has no financial relationships to disclose. Thomas H Bak, MD University of Edinburgh, UK Thomas H Bak has received grant/research support from ESRC, WFN, MND Association (UK) and MND Scotland. Kailash Bhatia, MD Institute of Neurology, London Kailash Bhatia has served as a consultant for GSK, Orion, Ipsen, Merz and LLC; has received grant/research support from Ipsen, Halley Steward Trust, the wellcome trust MRC,Dystonia coalition and PD UK; has received honoraria from MDS, EFN, ENS, Ipsen, Mertz, GSK, Orion, LLC and Boehringer Ingelheim; has intellectual property rights with Oxford Press; and receives royalties from Oxford Press. Matteo Bologna, MD PhD Sapienza University of Rome, Italy Matteo Bologna has received grant/research support from Dystonia Coalition (NS065701). Luc Buée, PhD Inserm UMR837, Univ. Lille, CHR, Lille, France Luc Buée has intellectual property rights with Inventor Patents. 4 David J Burn, MD, FRCP Institute of Neuroscience Newcastle University, UK David J Burn has received grant/research support from GlaxoSmithKline; and has received royalties from Henry Stewart Associates (publishing). Richard Dodel, MD Klinik für Neurologie Philipps-Universität Universitätsklinikum Gießen und Marburg GmbH, Germany Richard Dodel has received grant support from Baxter, Bayer Schering, Behring-Rontgen-Stiftung, BMBF, CSL Behring, Deutsche Gesellschaft fur Neurologie, Deutsche Parkinson Vereinigung, DGSM Deutsche Gesellschaft für Schlafmedizin, Faber-Stiftung, Hector-Stiftung, Internationale Parkinson Fonds, Lundbeck, Medtronic, M.J.Fox Foundation, Movement Disorder Society, Novartis, Rentschler, UKGM, ZLB Behring, Deutsche Forschungsgemeinschaft; has received personal fees from Astra Zeneca, Baxter, Boehringer Ingelheim, Canadian Blood Services, Contingo Consulting, CSL Behring, Deutsche Fortbildungsgesellschaft HNO-Ärzte, Deutsche Ophthalmologische Gesellschaft, DZNE Deutsches Zentrum für neurodegenerative Erkrankungen, Eisai, Elsevier, GlaxoSmithKline, Helios Klinik Wuppertal, Hessisches Ministerium für Arbeit, Familie und Gesundheit, Klinikum Ludwigsburg, Klinikum Münster, Lilly, Lundbeck, Med Panel, Medizinische Hochschule Hannover, Medizinisch-Naturwissenschaftliche Gesellschaft Wuppertal, Merz Pharmaceuticals, Neurologie Regensburg, Novartis, Octapharma,
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