FINAL PROGRAM

Melbourne, Australia | November 15–19 | www.melbourne2015.org

Under the auspices of: INTERNATIONAL XENOTRANSPLANTATION ASSOCIATION

IPITA • IXA • CTS | www.melbourne2015.org ACKNOWLEDGEMENT to SPONSORS

The 2015 Joint Congress of IPITA, IXA and CTS would like to acknowledge the following companies and organisations for their generous contribution.

GOLD LEVEL

siLVER LEVEL

BRONZE LEVEL

cONtRiBUtORs

TSANZ The Transplantation Society of Australia and New Zealand

MELBOURNE

November 15–19, 2015 | Melbourne, Australia 1 IPITA • IXA • CTS | www.melbourne2015.org TABLE of CONTENTS

Welcome Letters A Word from the Congress Chair ...... 3 Letter from the Section Presidents ...... 4 Welcome Message from the Victoria Minister of Health ...... 5 congress committees List ...... 6 information about societies About IPITA ...... 7 About IXA ...... 8 About CTS ...... 9 About TTS ...... 10 Best Young investigator scientific Awards ...... 11–16 invited speakers ...... 17–18 session chairs ...... 19 Abstract Reviewers ...... 20–21 congress information ...... 22–25 Young investigator Activities ...... 26 social Activities ...... 27 information on Melbourne ...... 28–31 Program-at-a-Glance ...... 32–33 Detailed Program Day 1: Sunday, November 15, 2015 ...... 35–38 Day 2: Monday, November 16, 2015 ...... 41–53 Day 3: Tuesday, November 17, 2015 ...... 55–73 Day 4: Wednesday, November 18, 2015 ...... 75–90 Day 5: Thursday, November 19, 2015 ...... 93–99 Exhibit information Exhibitor Hours, Floor Plan and List of Exhibitors ...... 100 Sponsor Descriptions ...... 101–105 Contributors ...... 106 Exhibitor Descriptions ...... 107–110 Presenter index ...... 111–116

2 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org A WORD from the CONGRESS CHAIR

DearColleagues, WelcometotheJointCongressandthankyoutoallofyouwhohavecomefromoverseas–believe me,thoseofuswholiveinAustraliaknowhowfarawayweare! Melbournewasrecentlynamedtheworld’smostliveablecityforthe5thyearinarowbyThe Economist.Weareparticularlyproudofourstronghistoryandpresentstrengthinmedicalresearch withboththeUniversityofMelbourneandMonashUniversityhavinghighly-rankedmedicalschools. WeareespeciallystronginimmunologywithgreatnamesofthepastsuchasBurnet,Nossal,Jacques Miller,IanMackay,PeterMorris,IanMcKenzieandmanyothersworkinghere,aswellasmanycurrent luminariesincludingofcoursePeterDohertyafterwhomamajorinstitutehasrecentlybeennamed. ThisisagreattimeoftheyeartovisitMelbourne.SpringisverymuchintheairandMelbourne’srather greyandwetwinterandobsessionwithAustralianRulesFootballisoverfortheyear.Springto MelburniansmeansnotonlyhayfeverbuttheSpringRacingCarnivalculminatingintheMelbourne Cup,whichwasheldtwoweeksago,andthecomingcricketseasoninwhichAustraliawillplayagainst touringteamsfromNewZealandandtheWestIndies.ThetraditionalBoxingDaytestwillbeonlyjust overwhentheAustralianOpentennischampionshipbegins.YoucanseeMelbourneissportsmadand thatiswhyourCongressDinnerwillbeheldattheMelbourneCricketGround–oneoftheworld’sgreat stadiumsandhomeofthe1956Olympicsaswellasregularfootballandcricketmatches–thisyear over98000peopleattendedthefootballGrandFinal. ButMelbourneisnotjustaboutsport–thereisarichmulticulturalsocietywithnearlytwocenturiesof diverseimmigrationresultingmostobviouslyinafantasticrangeofrestaurantsandlocalwines.Ihope youwilltaketheopportunitytoenjoythese–inmoderationofcourse.Therearealsomanygreen spaceswithinourlargecity–makesureyouleavetimeforawalkinourbeautifulRoyalBotanic Gardensthatremindusofourcolonialpast.Andusethetramnetwork,laidoutinthe19th Centurywhen MelbournewasoneoftherichestcitiesintheworldthankstoourGoldRush,togetaroundtown.It’s freeintheCBD. Themostimportantthingofcourseistheopportunityforscientificexchangewithcolleaguesfrom aroundtheworldandIhopeyouwillagreeourProgramCommitteehasputtogetherareallystrong foundationforthesediscussions. Ilookforwardtomeetingallofyouhere–pleasecomeandaskmeforanylocaltips,I’llbesohappy toshare! Yourssincerely,

tom Kay CongressChair IPITA-IXA-CTS2015JointCongress

November 15–19, 2015 | Melbourne, Australia 3 IPITA • IXA • CTS | www.melbourne2015.org LETTER from the SECTION PRESIDENTS

DearCongressParticipants, AsPresidentsoftheInternationalPancreasandIsletTransplantAssociation(IPITA),theInternational XenotransplantationAssociation(IXA),andtheCellTransplantSociety(CTS),itisourprivilegeto welcomeallparticipantstotheIPITA-IXA-CTS2015JointCongress.ThepartnershipbetweenIPITA, IXA,andCTSbringstogetherexcellenceinbasicandclinicaltransplantationscienceandleadership fromaroundtheworld.Thisyear’sJointCongressisatestamenttothebenefitsofworkingtogether, andisatremendousopportunityforourmemberstobroadentheirnetworksandlearnfromeachother, aswellasdiscussthemescommontoallthreeSections. Thisyear’sprogrampromisestobechallengingandengagingwhileaffordingattendeesthechanceto explorebeautifulMelbourne.SomeofthehighlightsincludethepresentationoftheIPITA-IXA-CTS-TTS 2015ScientificAwards,takingplacealongwiththeJointPresidentialSession,andtheCongress Dinner,whichwillbehostedattheimpressiveMelbourneCricketGround.Welookforwardtoseeing familiarfacesandmakingnewconnectionsattheseeventsandthroughouttheCongress. Finally,wewouldliketoextendourthanksandgratitudetothisyear’sCongressSponsorsand CongressCommittees,withoutwhomthiseventwouldnotbepossible.Toallparticipants,wehopethat youareabletotakefulladvantageoftheeducationalandsocialaspectsofthisyear’sexcitingprogram. OnbehalfofIPITA,IXA,andCTS,wewishyouanenjoyableandsuccessful2015JointCongress. Sincerely,

Bernhard Hering President,IPITA

takaaki Kobayashi President,IXA

Maria Koulmanda President,CTS

4 Joint congress of the iPitA, iXA and cts WELCOME MESSAGE from the VICTORIA MINISTER of HEALTH

OnbehalfoftheAndrewsLaborGovernment,IofferyouaverywarmwelcometoVictoriaforthe IPITA-IXA-CTS2015JointCongress. Victoriaisaworld-leaderinhealthandmedicalresearch,andIamincrediblyproudoftheworkbeing doneatourhospitals,ourmedicalresearchinstitutes,andouruniversitiestoimprovepatients’lives, theirexperiences,andtheiroutcomes. Victoriaishometoaround150biotechnologycompanies,10majormedicalresearchinstitutes,10 teachinghospitalsconductingsignificantresearch,and9universities,andouroutstandinghealthand medicalresearchcapabilitiesacrossarangeoffieldsarerecognisedbothnationallyandglobally. Throughinternationalpartnerships,wemayfindnewsolutionstoglobalhealthchallenges,soIhope thisconferencewillbeanopportunitytolearnandshareyourknowledgeandexpertise,strengthen existingfriendshipsandbuildnewones,andidentifyandenhancecollaborationopportunities. IalsohopeyouwillhavethechancetoenjoysomeofVictoria’smanyfantastichighlights. Melbourneisacitycelebratedforitsfood,shopping,sports,arts,cultureandyearroundfestivities,and, withinastone'sthrowofthecity,wehavespectacularcoastlines,Australianwildlifereserves,wineries, temperaterainforests,surfbeaches,skifieldsandhistorictownships. Pleaseenjoyyourtimehereinourwonderfulstate,andIwishyoutheverybestforavery productiveconference. Yourssincerely,

Hon Jill Hennessy MP MinisterforHealth StateGovernmentofVictoria

November 15–19, 2015 | Melbourne, Australia 5 IPITA • IXA • CTS | www.melbourne2015.org CONGRESS COMMITTEES LIST

CONGRESS CHAIR CONGRESS EXECUTIVE COMMITTEE ProfessorThomasKay,Australia PeterCowan,Australia AnilDhawan,UnitedKingdom PaulJohnson,UnitedKingdom CONGRESS CO-CHAIR and ThomasKay,Australia SCIENTIFIC COMMITTEE CHAIR TakaakiKobayashi,Japan PeterCowan,Australia MariaKoulmanda,UnitedStates PhilipO'Connell,Australia MeganSykes,UnitedStates

SCIENTIFIC PROGRAM COMMITTEE CurieAhn,Korea MariaKoulmanda,UnitedStates StephenAlexander,Australia BarbaraLudwig,Germany ThierryBerney,Switzerland JamesMarkmann,UnitedStates RichardBoyd,Australia WilliamMulley,Australia PatrickT.Coates,Australia JonS.Odorico,UnitedStates DavidK.Cooper,UnitedStates LorenzoPiemonti,Italy PeterCowan,Australia EdwardStanley,Australia AnilDhawan,UnitedKingdom PeterStock,UnitedStates KarenDwyer,Australia TerryStrom,UnitedStates CesareGalli,Italy HelenThomas,Australia ShaneGrey,Australia KazuhikoYamada,UnitedStates GeoffreyHill,Australia

LOCAL ORGANIZING COMMITTEE RichardAllen,Australia IanMcKenzie,Australia JeremyChapman,Australia BrianNankivell,Australia PeterCowan,Australia PhilipO'Connell,Australia Anthonyd'Apice,Australia HenryPleass,Australia KarenDwyer,Australia NadiaRosenthal,Australia WayneHawthorne,Australia AlanSaunder,Australia FrancescoIerino,Australia HelenThomas,Australia ThomasKay,Australia ShounanYi,Australia RobertM.I.Kapsa,Australia

6 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org INFORMATION ABOUT the SOCIETIES

TheInternationalPancreasandIsletTransplantation Association(IPITA)aimstoservethepancreasand islettransplantscientificcommunityinprovidinga forumfortheopenexchangeofknowledgeand expertiseinordertofacilitatetheadvancementof theclinicalpracticeofpancreasandislet transplantationforthetreatmentofhumandiabetes.

Aims of the Association Topromoteandencourage Toprovideascientific Topromoteandencourage 1 researchandtraining 2 forumfortheexchangeand 3contactsbetweenclinicaland relevanttotransplantationof discussionofclinicaland experimentalresearchersfrom insulinproducingtissuein experimentalresultsand differentinstitutionsandfromall thetreatmentandcureof experiencesrelevantto pertinentdisciplines. diabetesmellitus. transplantationofinsulin producingtissueinthetreatment andcureofdiabetesmellitus.

2013-2015 COUNCIL MEMBERS

President: BernhardHering,UnitedStates councilors: MitsukazuGotoh,Japan President-Elect: JonOdorico,UnitedStates RajaKandaswamy,UnitedStates Past President: PaulJohnson,UnitedKingdom ThomasKay,Australia secretary: JamesMarkmann,UnitedStates BarbaraLudwig,Germany treasurer: ThierryBerney,Switzerland PeterStock,UnitedStates

IPITA EVENTS DURING THE 2015 MELBOURNE CONGRESS November 16th DerekGrayAwardLecture 13:30–15:00inPlenaryRoom1 IPITABusinessMeeting 17:00–17:30inMeetingRoom110 November 17th RichardC.LilleheiLecture 13:30–15:00inPlenaryRoom1 November 18th PaulE.LacyLecture 13:30–15:00inPlenaryRoom1 November 19th PresidentialAddressandAwards 09:00-10:30inPlenaryRoom1

November 15–19, 2015 | Melbourne, Australia 7 InternationalIPITA • IXA • CTS Society | www.melbourne2015.org for Organ Donation and Procurement | www.isodp.org INFORMATIONINVITED SPEAKERS ABOUT the SOCIETIES

TheInternationalXenotransplantationAssociation (IXA)wasestablishedattheMontreal'98Congress INTERNATIONAL ofTheTransplantationSociety,withtheaimof XENOTRANSPLANTATION providingaforumforthosewithaspecialinterestin ASSOCIATION Xenotransplantation.

the iXA’s mission is to promote xenotransplantation as a safe, ethical, and effective therapeutic modality by:

Fosteringthescienceof Educatinghealthcare Guidingthedevelopmentof 1 xenotransplantationthrough 2 providersandlaypersons 3 scientificallysound, promotionofethicalclinicaland throughbroad,representative internationallyconsistentpublic pre-clinicalresearch,productive participationininteractivepublic policythatisresponsivetonew discourse,andcollaboration. debate. developmentsinthefieldand acknowledgesvaryingsocial, ethicalandlegalframeworks.

TheIXA’scoremissioniscloselyalignedwiththeprinciplesoutlinedintheCartagenaProtocolon BiologicalDiversity.Thisinternationalagreementdescribesinternationalnormsfortheuseof geneticallymodifiedanimals“tocontributetothedevelopmentofhumanwelfareandthepromotionof environmentalconservationonaglobalbasis.” 2013-2015 COUNCIL MEMBERS

President: TakaakiKobayashi,Japan councilors: GillesBlancho,France President-Elect: PeterCowan,Australia MichaelBreimer,Sweden Past President: BernhardHering,UnitedStates ShujiMiyagawa,Japan secretary and Chung-GyuPark,SouthKorea treasurer: AgnesAzimzadeh,UnitedStates DavidH.Sachs,UnitedStates EckhardWolf,Germany

IXA EVENTS DURING THE 2015 MELBOURNE CONGRESS November 17th KeithReemtsmaLecture 13:13–15:00inPlenaryRoom1 IXAHonoraryMemberLecture 16:30–17:00inRoom109 IXABusinessMeeting 17:00–17:30inMeetingRoom109 November 19th PresidentialAddressandAwards 09:00-10:30inPlenaryRoom1

8 13th Congress of theJoint congress of the iPitA, iXA and cts International Society for Organ Donation and Procurement IPITA • IXA • CTS | www.melbourne2015.org INFORMATION ABOUT the SOCIETIES

TheCellTransplantSociety(CTS)existstobethe leaderindevelopingandtranslating,safecellularand regenerativetherapiestopatients.TheSocietywill promoteresearch,collaborationandfocuson regulatorymatters,astheyrelatetoclinicaltranslation. cts Objectives TheSocietyshallpromote TheSocietyshall TheSocietywillreceive, 1 andencourageeducation 2 collaboratewithexisting 3 use,holdandapplyfunds, andresearchwithrespectto publicandprivateorganizations gifts,bequestsandendowments, cellulartransplantation. topromoteandencourage ortheproceedsthereof,toanyof educationandresearchin thepurposesdescribedherein. cellulartransplantationandwill participateandassistinthe coordinationofeffortsor formulationofresearchand clinicalprograms.

2013-2015 COUNCIL MEMBERS

President: MariaKoulmanda,UnitedStates councilors: EwaEllis,Sweden President-Elect: AnilDhawan,UnitedKingdom RobertA.Fisher,UnitedStates Past President IraFox,UnitedStates and secretary:StephenStrom,Sweden KazuoOhashi,Japan treasurer: JohnnyHuard,UnitedStates KlearchosPapas,UnitedStates TerryB.Strom,UnitedStates

CTS EVENTS DURING THE 2015 MELBOURNE CONGRESS November 17th InauguralCamilloRicordiLecture 13:30–15:00inPlenaryRoom1 November 18th CTSBusinessMeeting 17:00–17:30inMeetingRoom111-112 November 19th PresidentialAddressandAwards 09:00-10:30inPlenaryRoom1

November 15–19, 2015 | Melbourne, Australia 9 IPITA • IXA • CTS | www.melbourne2015.org INFORMATION ABOUT the SOCIETIES

TheTransplantationSocietyisaninternational forumfortheworldwideadvancementoforgan transplantation.Itprovidesfocusforglobal leadershipintransplantation,including developmentofthescienceandclinicalpractice, scientificcommunication,continuingeducationand guidanceontheethicalpractice. TheTransplantationSocietyisproudtobethehub contact information linkingworld-renownedassociationsrelatedto 505boul.René-LévesqueOuest,Suite1401 transplantation.FormoreinformationaboutTTSor Montreal,QC,CanadaH2Z1Y7 anyofitssectionsincludingIPITA,IXAandCTS, Tel:+1.514.874.1717Fax:+1.514.874.1716 visitwww.tts.org. Email:[email protected]/[email protected]

2014-2016 COUNCIL MEMBERS

President: PhilipJ.O’Connell,Australia President-Elect: NancyL.Ascher,UnitedStates Past President: FrancisL.Delmonico,UnitedStates Vice President: MarceloCantarovich,Canada WOMEN in Transplantation secretary: GabrielDanovitch,UnitedStates senior treasurer: JohnJ.Fung,UnitedStates Networking Breakfast th treasurer: ElmiMuller,SouthAfrica November 18 – 07:00 – Room 109 councilors: BeatrizDomínguez-Gil,Spain Joinprominentwomenleadersinthefieldof JosetteEris,Australia transplantationforapaneldiscussionaboutthe RudolfGarcia-Gallont,Guatemala challengesofcareerdevelopment,the JongwonHa,Korea importanceofmentorshipinyourcareerand VivekanandJha,India howtoachievework-lifebalanceduringthis DirkR.J.Kuypers,Belgium networkingbreakfast.Theeventisopentoall AlejandroNinoMurcia,Colombia attendeesregisteredtoattendtheCongress. MinnieSarwal,UnitedStates MeganSykes,UnitedStates ShiroTakahara,Japan StefanG.Tullius,UnitedStates IfeomaUlasi,Nigeria

10 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SCIENTIFIC AWARDS

TheTransplantationSocietyandtheIPITA,IXA,andCTSarepleasedtoannouncetherecipientsofthe 2015IPITA-IXA-CTSBestYoungInvestigatorsScientificAwards.Theawardswillbepresentedin conjunctionwiththeIPITA-IXA-CTSJointPresidentialSessiononThursday,November19th from 09:00to10:30. Lookfortheintheprogram,whichidentifiestheawardwinners.

INTERNATIONAL PANCREAS AND ISLET TRANSPLANT ASSOCIATION WINNERS Ahmed Arzouni, United Kingdom 541 EFFECTSOFACTIVATEDMESENCHYMALSTROMALCELLSONISLETSECRETORY FUNCTIONANDCELLULAROVERGROWTHONMICROENCAPSULATEDISLETS Robert crookston, United Kingdom 592 AQUALITATIVEEVALUATIONOFPATIENTEXPERIENCESFOLLOWING ISLETTRANSPLANTATION Brian Eby, United states 335 VIRTUALHLACROSSMATCHINGUSINGSINGLEANTIGENBEADLUMINEXASSAYS SAFELYEXPEDITESTRANSPLANTATIONOFIMPORTEDPANCREATA Julie Hayward, canada 520 MESENCHYMALSTEMCELLSCO-TRANSPLANTEDWITHNEONATALPORCINEISLETS IMPROVEREVASCULARIZATION,MORERAPIDCORRECTIONOFDIABETESAND LONG-TERMGRAFTFUNCTIONINDIABETICMICE Mazhar Kanak, United states 323 WITHAFERINAPREVENTSISLETDAMAGECAUSEDBYIBMIR:microRNA375ANALYSIS Hussein Khambalia, United Kingdom 267 SUPRA-PHYSIOLOGICALHAEMODYNAMICOPTIMISATIONIMPROVESSHORT-TERM OUTCOMESFOLLOWINGSIMULTANEOUSPANCREASANDKIDNEYTRANSPLANTATION: ARANDOMISEDCLINICALTRIAL Rahul Krishnan, United states 545 AUTOMATIONOFMICROCAPSULEEVALUATIONANDCHARACTERIZATIONFORUSEIN ISLETTRANSPLANTATION chao Li, People’s Republic of china 788 PROTECTIVEEFFECTOFCYANIDIN-3-O-GLUCOSIDEONXENOTRANSPLANTED NEONATALPORCINEISLETSTHROUGHERK1/2ANDPI3K/Akt-INDUCEDNrf2-MEDIATED HO-1INDUCTION

November 15–19, 2015 | Melbourne, Australia 11 IPITA • IXA • CTS | www.melbourne2015.org SCIENTIFIC AWARDS

Gopalakrishnan Loganathan, United states 1040 STIMULATIONOFHUMANINTRAISLETENDOTHELIALCELLSYIELDSPERI-ISLET CAPILLARIES:ROLEOFADIPOSE-DERIVEDSTROMALVASCULARFRACTIONCELLS ANDECGSSOLUTION Andrew Pepper, canada 539 THEDEVELOPMENTANDUTILITYOFAPREVASCULARIZEDSUBCUTANEOUS‘DEVICE- LESS’SITEFORBETACELLREPLACEMENTTHERAPY Nancy Radke, United states 338 SIROLIMUSRESCUEMAINTENANCETHERAPYFORREFRACTORYPANCREAS REJECTION Robert Redfield iii, United states 333 INCIDENCE,OUTCOMESANDPREDICTORSOFDENOVODONORSPECIFICANTIBODYIN PANCREASTRANSPLANTATION sara sackett, United states 461 MATURATIONOFHUMANPLURIPOTENTSTEMCELL-DERIVEDPANCREATICPROGENITORS INTOMONOHORMONALISLET-LIKECELLSAFTERTRANSPLANTATIONTOMICE Letícia terra, Brazil 859 PRLPROTECTIONOFBETA-CELLGENERALDAMAGERESTOREAUTOPHAGYMARKERS sara Ullsten, sweden 378 SCHWANNCELLSREGULATEANGIOGENESISANDBLOODVESSELSTRUCTUREINNATIVE ANDTRANSPLANTEDPANCREATICISLETS Wensheng Zhang, United states 725 ANOVELTHERAPYUSINGLOCALIZEDDELIVERYOFBIOPATTERNEDCTLA4/Fc FUSION PROTEINSTOPROMOTEISLETALLOGRAFTSURVIVALANDTOLERANCE

12 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SCIENTIFIC AWARDS

INTERNATIONAL XENOTRANSPLANTATION ASSOCIATION WINNERS Esme Dijke, canada 214 CRYOPRESERVEDREGULATORYTCELLS(TREGS)ISOLATEDFROMDISCARDEDHUMAN THYMUSPOTENTLYSUPPRESSALLOGENEICANDXENOGENEICIMMUNERESPONSES AFTEREXPANSION Beth French, United states 1055 IL-8ELABORATIONMAYCONTRIBUTETOGalTKO.hCD46LUNGXENOGRAFTINFLAMMATION Laura Higginbotham, United states 375 LONG-TERMSURVIVALOFPIG-TO-PRIMATERENALXENOTRANSPLANTUSING COSTIMULATION-BLOCKADEIMMUNOSUPPRESSION Hayato iwase, United states 475 EFFECTOFPIGGENETICMODIFICATIONONHUMANPLATELETAGGREGATIONIN RESPONSETOPIGVASCULARENDOTHELIALCELLS Jaeyoung Kim, Korea 412 EFFECTANDSAFETYOFANTI-CD40ANTIBODYONTHESURVIVALOFCORNEAL XENOTRANSPLANTATION Hyun Je Kim, Korea 281 ANEWBIOINFORMATICSANALYSISREVEALSINTESTINALINFECTIONASAPOSSIBLE CAUSEOFINTRAHEPATICGRAFTREJECTIONINNON-HUMANPRIMATEPORCINEISLET XENOTRANSPLANTATION Whayoung Lee, United states 553 INVESTIGATIONOFTHEPOTENTIALCLINICALSIGNIFICANCEOFTHEEXPRESSIONOF NEUGCONPIGAORTASANDCORNEAS Natacha Madelon, switzerland 462 PROTECTIVEPOTENTIALOFMURINEIL-10-INDUCEDTOLEROGENICDENDRITICCELLSIN RAT-TO-MOUSEISLETSXENOTRANSPLANTATIONMODEL Gregory R. Martens, United states 550 GGTA1/CMAH/β4GaLNT2KNOCKOUTPORCINECELLSHAVEREDUCEDHUMANANTIBODY BINDINGANDACHIEVEDNEARBACKGROUNDTHRESHOLDSFORMOSTTRANSPLANT PATIENTSANDREMAININGANTIBODYBINDINGISPARTIALLYATTRIBUTABLETOSWINE LEUKOCYTEANTIGEN Byoung-Hoon Min, Korea 647 HEPATICSTEATOSISINIMMUNOSUPPRESSEDDIABETICNON-HUMANPRIMATE TRANSPLANTEDWITHPIGISLETS

November 15–19, 2015 | Melbourne, Australia 13 IPITA • IXA • CTS | www.melbourne2015.org SCIENTIFIC AWARDS

Yi Wen Qian, Australia 416 Foxp3+REGULATORYTCELLSAREESSENTIALFORTHEINDUCTIONAND MAINTENANCEOFTOLERANCETONEONATALPORCINEISLETCELLCLUSTER XENOGRAFTSINDUCEDBYCO-STIMULATORYBLOCKADE Jun-seop shin, Korea 648 THECONSEQUENCEOFLONG-TERMSURVIVALOFPORCINEISLETGRAFTIN IMMUNOSUPPRESSEDNON-HUMANPRIMATES:GIVINGANOPPORTUNITYTOADDRESS THREEIMPORTANTISSUESINISLETXENOTRANSPLANTATION Yixiong tan, Australia 650 HUMANREGULATORYMACROPHAGESINDUCEDINVITROAREHIGHLYSUPPRESSIVEIN XENO-BASEDIMMUNERESPONSE Aseda tena, United states 376 PROLONGEDSURVIVALOFPORCINESKINONBABOONSFOLLOWINGADMINISTRATION OFPORCINECELLSEXPRESSINGHUMANCD47 Mehmet c. Uluer, United states 1059 GalTKO.hCD46+/+.NEU5GCKOPORCINELIVERSPRESERVEPLATELETCOUNTSDURING EXTRA-CORPOREALPERFUSIONWITHHUMANBLOOD Ji-Jing Yan, Korea 278 OVEREXPRESSIONOFHUMANHO-1ORsTNF-αR-Fc INADULTPORCINEISLETSUSING ADENOVIRALTRANSDUCTIONORTRANSGENICPIGSPROLONGSISLETXENOGRAFT SURVIVALBYSUPPRESSINGBOTHEARLYAPOPTOSISANDINFLAMMATION

14 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SCIENTIFIC AWARDS

CELL TRANSPLANT SOCIETY WINNERS sana Asif, sweden 561 CONJUGATIONOFHUMANRECOMBINANTCD39TOPRIMARYHUMANHEPATOCYTES PROTECTSAGAINSTTHROMBOINFLAMMATION Maria coronel, United states 364 INSITUOXYGENBIOMATERIALFOREXTRAHEPATICISLETTRANSPLANTATION Joanna cwykiel, United states 379 APPLICATIONOFHUMANEPINEURALSHEATHCONDUITSUPPORTEDBYHUMAN MESENCHYMALSTEMCELLSTHERAPYFORREGENERATIONOFPERIPHERAL NERVEINJURIES Melissa Davis, United states 833 STIMULATIONOFPORCINEBETA-CELLPROLIFERATIONISINHIBITEDWITHHYPOXIC CULTURECONDITIONS Gaetano Faleo, United states 828 AMINOACIDSUPPLEMENTATIONPREVENTSISLETCELLSDEATHFROMNUTRIENT DEPRIVATIONDURINGTHEPERI-TRANSPLANTPERIOD Raquel Fernandez Dacosta, United Kingdom 380 INVESTIGATIONOFTHEMITOCHONDRIALTRANSFERFROMHUMANMESENCHYMAL STEM/STROMALCELLSTOHUMANPRIMARYHEPATOCYTESTHROUGHTUNNELLING NANOTUBESASAPOTENTIALMECHANISMFORCELLSURVIVALANDFUNCTION ENHANCEMENTDURINGHEPATOCYTETRANSPLANTATION Anthony Frei, United states 536 ENGINEERINGANINVITROPLATFORMFORCHARACTERIZATIONOFANTIGEN RECOGNITIONFORENCAPSULATEDISLETS Liza Grapensparr, sweden 1068 INTRACARDIALLYINJECTEDNEURALCRESTSTEMCELLSHOMETOTHEPANCREASAND DELAYSDISEASEPROGRESSIONINANANIMALMODELFORTYPE1DIABETES Periklis Kyriazis, United states 562 ISLETRESIDENTMACROPHAGESAREIMMUNOREGULATORYANDPROLONGISLET TRANSPLANTSURVIVAL sharon Lehec, United Kingdom 767 NEONATALDCDLIVERSWITHLONGWARMISCHEMICTIMESCANPRODUCEGOOD QUALITYCLINICALGRADEHEPATOCYTES

November 15–19, 2015 | Melbourne, Australia 15 IPITA • IXA • CTS | www.melbourne2015.org SCIENTIFIC AWARDS

Xiaoqian Ma, People’s Republic of china 560 CTLA-4PLAYSANIMPORTANTROLEINTREG-MEDIATEDSUPPRESSIONOFTHE XENOIMMUNERESPONSE Fabio Marongiu, italy 848 AMNIOTICEPITHELIALCELLSDIFFERENTIATEINTOHEPATICSINUSOIDALENDOTHELIAL CELLSINVIVO Kate smith, United states 827 ACUTEISCHEMICEXPOSURELEADSTOFUNCTIONALDEFICITSANDATRANSCRIPTOME ENRICHEDININFLAMMATORYANDHYPOXICPATHWAYSINHUMANISLETS Leah steyin, United states 1066 INSITUOXYGENDELIVERYTOISLETSWITHINANIMPLANTABLEIMMUNOISOLATING DEVICEINVIVOENHANCESVIABILITYANDFUNCTION

16 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org INVITED SPEAKERS

Appakalai Balamurugan, UnitedStates Raja Kandaswamy,UnitedStates stephen t. Bartlett, UnitedStates Fouad R. Kandeel,UnitedStates Franca B. Barton,UnitedStates thomas W. Kay, Australia Melena D. Bellin,UnitedStates Mary Kearns-Jonker,UnitedStates thierry Berney,Switzerland timothy J. Kieffer,Canada Louise Berry, UnitedStates Jim Kim,UnitedStates Guerard W. Byrne,UnitedKingdom Mee Kum Kim,Korea Daniel c. chambers,Australia takaaki Kobayashi,Japan Ann P. chidgey,Australia Maria Koulmanda,UnitedStates James chong,Australia John Lambris,UnitedStates Pratik choudhary, UnitedKingdom Whayoung Lee,UnitedStates David K.c. cooper,UnitedStates Joseph R. Leventhal,UnitedStates Peter cowan,Australia Andrew M. Lew,Australia Emanuele cozzi, Italy Melissa H. Little,Australia Rob J.R. crookston, UnitedKingdom tom Loudovaris, Australia sarah E. cross,UnitedKingdom Barbara Ludwig, Germany Peter D. currie,Australia torbjorn Lundgren,Sweden Yifan Dai,UnitedStates Rosemarie Masterson,Australia Robert Deans,UnitedStates Joan McElroy,UnitedStates Ashley Dennison,UnitedKingdom shinichi Matsumoto,Japan Kevin Docherty,UnitedKingdom christopher G.A. McGregor,UnitedKingdom Burcin Ekser,UnitedStates Mike A. McGuckin,Australia Ewa c. Ellis,Sweden Raphael Meier,Switzerland charles Esmon,UnitedStates Muhammad M. Mohiuddin,UnitedStates stefan A. Farkas,Germany Bashoo Naziruddin,UnitedStates Konrad Federlin,Germany David Nikolic-Paterson,Australia Pablo Ferrari, Australia Jose Oberholzer, UnitedStates Robert Fisher,UnitedStates Philip J. O’connell,Australia Jonathan A. Fridell,UnitedStates Jon s. Odorico,UnitedStates Peter J. Friend,UnitedKingdom Kazuo Ohashi,Japan Uri Galili,UnitedStates Klearchos K. Papas, UnitedStates Edward K. Geissler,Germany chung-Gyu Park,Korea Pierre R. Gianello,Belgium Francois Pattou,France Maria Golson,Belgium Martin Pera, Australia Roberto Gramignoli,Sweden Lorenzo Piemonti,Italy shane t. Grey,Australia Richard N. Pierson,UnitedStates Angelika c. Gruessner,UnitedStates Andrew M. Posselt,UnitedStates Duck Jong Han,Korea Guido Pozza,Italy Mark A. Hardy,UnitedStates Alberto Pugliese,UnitedStates Bernhard J. Hering,UnitedStates Anita Quigley,Australia Rhonda Holdsworth,Australia toni Radford,Australia Kathy Howe,Australia Nancy Radke,UnitedStates Johnny Huard,UnitedStates William D. Rawlinson,Australia Albert Hwa, UnitedStates Michael R. Rickels,UnitedStates silviu itescu,Australia camillo Ricordi,UnitedStates Hayato iwase,UnitedStates Horacio L. Rilo,UnitedStates stewart sinclair Jessamine,NewZealand Paul Robertson, Australia Paul Johnson,UnitedKingdom Mauro s. sandrin, Australia

November 15–19, 2015 | Melbourne, Australia 17 IPITA • IXA • CTS | www.melbourne2015.org INVITED SPEAKERS

Frantisek saudek,CzechRepublic christian schuetz,UnitedStates Hanne scholz,Norway Linda scobie,UnitedKingdom Evan Y. snyder,UnitedStates Hans W. sollinger,UnitedStates sean stevens,UnitedStates Peter G. stock,UnitedStates David E.R. sutherland, UnitedStates Qizhi tang,UnitedStates Alfred Joseph tector,UnitedStates shuji terai,Japan Helen E. thomas,Australia Alan O. trounson,Australia Piotr trzonkowski,Poland Euan M. Wallace,Australia Gordon Wallace,Australia Lori J. West,Canada Eckhard Wolf, Germany Raymond Wong, Australia Kazuhiko Yamada,UnitedStates Jaseok Yang,Korea shounan Yi,Australia Nathan Zammit,Australia

18 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SESSION CHAIRS curie Ahn, Korea Julie Kerr-conte, France takayuki Anazawa, Japan Mee Kum Kim, Korea titus Augustine, UnitedKingdom takaaki Kobayashi, Japan David Ayares, UnitedStates Greg s. Korbutt, Canada Agnes M. Azimzadeh, UnitedStates Maria Koulmanda, UnitedStates Appakalai Balamurugan, UnitedStates Yogish c. Kudva, UnitedStates stephen t. Bartlett, UnitedStates Joseph R. Leventhal, UnitedStates Melena D. Bellin, UnitedStates Eli c. Lewis, Israel Ekaterine Berishvili, Switzerland Melissa H. Little, Australia thierry Berney, Switzerland tom Loudovaris, Australia Gilles Blancho, France Barbara Ludwig, Germany Richard L. Boyd, Australia Paola Maffi, Italy Daniel Brandhorst, UnitedKingdom shinichi Matsumoto, Japan Kenneth L. Brayman, UnitedStates ian F.c. McKenzie, Australia Leo Hans Buehler, Switzerland Muhammad M. Mohiuddin, UnitedStates chris Burlak, UnitedStates Bashoo Naziruddin, UnitedStates Guerard W. Byrne, UnitedKingdom Philip J. O’connell, Australia John casey, UnitedKingdom Jose Oberholzer, UnitedStates Mark s cattral, Canada Jon s. Odorico, UnitedStates Ann P. chidgey, Australia Kazuo Ohashi, Japan Pratik choudhary, UnitedKingdom Klearchos K. Papas, UnitedStates Patrick t. coates, Australia chung-Gyu Park, Korea clark K. colton, UnitedStates Lorenzo Piemonti, Italy David K.c. cooper, UnitedStates Richard N. Pierson, UnitedStates Peter cowan, Australia Andrew M. Posselt, UnitedStates Emanuele cozzi, Italy toni Radford, Australia Rob J.R. crookston, UnitedKingdom Gina Rayat,, Canada sarah E. cross, UnitedKingdom Robert Redfield, UnitedStates Eelco E. de Koning, Netherlands Michael R. Rickels, UnitedStates Robert Deans, UnitedStates camillo Ricordi, UnitedStates Burcin Ekser, UnitedStates Horacio L. Rilo, UnitedStates Ewa c. Ellis, Sweden Mauro s. sandrin, Australia charles Esmon, UnitedStates Frantisek saudek, CzechRepublic Robert Fisher, UnitedStates David W. scharp, UnitedStates Peter J. Friend, UnitedKingdom Linda scobie, UnitedKingdom Uri Galili, UnitedStates Joerg D. seebach, Switzerland cesare Galli, Italy Peter A. senior, Canada Roberto Gramignoli, Sweden séverine sigrist, France shane t. Grey, Australia cherie L. stabler, UnitedStates Rainer W.G. Gruessner, UnitedStates Ed G. stanley, Australia Wayne J. Hawthorne, Australia Peter G. stock, UnitedStates Bernhard J. Hering, UnitedStates David E.R. sutherland, UnitedStates Johnny Huard, UnitedStates Megan sykes, UnitedStates Albert Hwa, UnitedStates Qizhi tang, UnitedStates Francesco L. ierino, Australia Alfred Joseph tector, UnitedStates claire F. Jessup, Australia shuji terai, Japan Paul Johnson, UnitedKingdom Helen E. thomas, Australia Raja Kandaswamy, UnitedStates Alan O. trounson, Australia Fouad R. Kandeel, UnitedStates Eckhard Wolf, Germany thomas W. Kay, Australia Kazuhiko Yamada, UnitedStates

November 15–19, 2015 | Melbourne, Australia 19 IPITA • IXA • CTS | www.melbourne2015.org ABSTRACT REVIEWERS

curie Ahn, Korea Roberto Gramignoli, Sweden Richard Allen, Australia Angelika c. Gruessner, UnitedStates takayuki Anazawa, Japan Rainer Gruessner, UnitedStates Helmut Arbogast, Germany Hidetaka Hara, UnitedStates David Ayares, UnitedStates Bernhard J. Hering, UnitedStates Agnes M. Azimzadeh, UnitedStates Francesco L. ierino, Australia Appakalai Balamurugan, UnitedStates Paul Johnson, UnitedKingdom Melena D. Bellin, UnitedStates Robert M.i. Kapsa, Australia Pierre-Yves Benhamou, France Dixon B. Kaufman, UnitedStates thierry Berney, Switzerland Mary Kearns-Jonker, UnitedStates Federico Bertuzzi, Italy takashi Kenmochi, Japan Gilles Blancho, France takaaki Kobayashi, Japan Domenico Bosco, Switzerland Maria Koulmanda, UnitedStates Rita Bottino, UnitedStates Jonathan R.t. Lakey, UnitedStates Richard L. Boyd, Australia Barbara Ludwig, Germany Michael E. Breimer, Sweden ian F.c. McKenzie, Australia Jonathan Bromberg, UnitedStates toshio Miki, UnitedStates Lars Burdorf, UnitedStates shuji Miyagawa, Japan chris Burlak, UnitedStates Muhammad M. Mohiuddin, UnitedStates Guerard W. Byrne, UnitedKingdom Eduard Montanya, UnitedStates Riccardo calafiore, Italy Elmi Muller, SouthAfrica Diego cantarovich, France Hiroshi Nagashima, Japan John casey, UnitedKingdom Brian J. Nankivell, Australia Mark s. cattral, Canada silke Niederhaus, UnitedStates Jeremy R. chapman, Australia Philip J. O’connell, Australia Beatrice charreau, France Jose Oberholzer, UnitedStates Patrick t. coates, Australia Jon s. Odorico, UnitedStates David K.c. cooper, UnitedStates Kazuo Ohashi, Japan cristina costa-Valles, Spain Klearchos K. Papas, UnitedStates Peter cowan, Australia steven Paraskevas, UnitedStates Emanuele cozzi, Italy chung-Gyu Park, Korea sarah E. cross, UnitedKingdom Lorenzo Piemonti, Italy Eelco E. de Koning, TheNetherlands Richard N. Pierson, UnitedStates Denis Dufrane, Belgium Henry Pleass, Australia ty Dunn, UnitedStates Alberto Pugliese, UnitedStates Burcin Ekser, UnitedStates Michael R. Rickels, UnitedStates Mohamed B. Ezzelarab, UnitedStates Robert Rieben, Switzerland Zhigang Fan, UnitedStates David H. sachs, UnitedStates christiane Ferran, UnitedStates Yusuke sakai, Japan celine Filippi, UnitedKingdom Mauro s sandrin, Australia Robert Fisher, UnitedStates Marten K.J. schneider, Switzerland Emer Fitzpatrick, UnitedKingdom Linda scobie, UnitedKingdom Peter J. Friend, UnitedKingdom Antonio secchi, Italy cesare Galli, Italy Joerg D. seebach, Switzerland Pierre R. Gianello, Belgium Peter A. senior, Canada Peter Girman, CzechRepublic Haval shirwan, UnitedStates Melanie Graham, UnitedStates Alejandro soto-Gutierrez, UnitedStates

20 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org ABSTRACT REVIEWERS

Zoe stewart, UnitedStates Peter G. stock, UnitedStates stephen c. strom, Sweden Megan sykes, UnitedStates Yasuhiro takeuchi, UnitedKingdom Alfred Joseph tector, UnitedStates Helen E. thomas, Australia tom thornley, UnitedStates Ralf R. tönjes, Germany Gunnar tufveson, Sweden David van Dellen, UnitedKingdom Kazuhiko Yamada, UnitedStates Yong-Guang Yan, UnitedStates shounan Yi, Australia Yasunami Yohichi, Japan

November 15–19, 2015 | Melbourne, Australia 21 IPITA • IXA • CTS | www.melbourne2015.org CONGRESS INFORMATION

PRESENTER GUIDELINES AllspeakershavetocheckintotheSpeakerReadyRoomatleast3hoursinadvanceoftheirsession todownloadtheirpresentationontothecentralcomputer. TheSpeakerReadyRoomislocatedontheGround Floor in the Box Office andwillbeopenduring thefollowinghours: n Sunday,November15th 11:00to18:00 n Monday,November16th 06:00to18:30 n Tuesday,November17th 06:00to17:30 n Wednesday,November18th 07:00to17:30 n Thursday,November19th 07:00to14:30 POSTER SESSIONS JointPostersSession1willbeheldintheMain Foyer 1 & 2 onNovember17th,from17:30to18:30 JointPostersSession2willbeheldintheMain Foyer 1 & 2 onNovember18th,from17:30to18:30 Mount Date and time for Presenters: JointPosterSession1:Tuesday,November17th from07:00to09:30 JointPosterSession2:Wednesday,November18th from07:00to09:30 Dismount Date and time for Presenters: JointPosterSession1:Tuesday,November17th from18:30to19:00 JointPosterSession2:Wednesday,November18th from18:30to19:00 REGISTRATION HOURS RegistrationislocatedintheMain Foyer 1 & 2 andwillbeopenduringthefollowinghours: n Sunday,November15th 12:00to18:00 n Monday,November16th 06:00to18:00 n Tuesday,November17th 06:30to18:00 n Wednesday,November18th 07:30to18:00 n Thursday,November19th 06:30to15:00 NAME BADGES Forsecurityandregulationpurposes,pleasewearyourbadgeduringallcongresssessionsand socialevents. INTERNET WiFi INFORMATION FreeWiFiwillbeprovidedthroughouttheCentre.Toaccess,pleaseselectthenetworknamed iPitA-iXA-cts andenterpasswordmelbourne 2015 (casesensitive).

22 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org CONGRESS INFORMATION

MEALS Pleasenotethatbreakfastandlunchareonown.Youwillfindnumerousrestaurantsandfoodcounters inandaroundthevenue. ABSTRACTS PUBLICATION Pleasenotethatallabstractsareavailableonlineonlyandcanbeviewedonthecongresswebsiteat www.melbourne2015.org. Additionally,theabstractswillbepublishedinonline supplementsofboththeTransplantation Journal as wellasXenotransplantation Journal.Linkstothese willbeadvertisedonsiteormaybeaccessedviathe publishers’webpage.

MOBILE APP ThefullMelbourneprogramaswellaspresenters’list,exhibitors’listanddescription,andmanymore features,willbemadeavailableviaacongressmobileapplication.TheAppwillpermityoutobrowse theprogramcontentperdayorpertrack,personalizeyouragendaandwillencouragesocialsharing. ThisapplicationisavailablebothontheAndroidstoreortheAppleAppstore,andfulldownloaddetails areavailableattheonsiteHelpDesk.

this mobile application is sponsored by Astellas transplant.

November 15–19, 2015 | Melbourne, Australia 23 IPITA • IXA • CTS | www.melbourne2015.org CONGRESS INFORMATION

WEB RECORDINGS Allregisteredattendeeswillhavethechancetoviewthecongresssessionrecordingsthroughthe websiteforuptoayearafterthecongress. CONGRESS LOCATION AND VENUE Thecongressisheldatthe Melbourne convention and Exhibition centre 1ConventionCentrePlace SouthWharfVIC3006 Melbourne,Australia Tel:61392358000

Registration Area Exhibit, Posters GroundFloor–MainFoyer1&2 GroundFloor–MainFoyer1&2 speaker Ready Room Breaks GroundFloor–BoxOffice GroundFloor–MainFoyer1&2 Plenary Room /Breakout Room Opening Reception GroundFloor–Plenary1 GroundFloor–MainFoyer1&2 symposia/Breakout Rooms congress Dinner Level1–Room109,110,111and112 MelbourneCricketGround BruntonAve,Richmond(Melbourne),VIC

24 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org CONGRESS INFORMATION

Entry 1 Foyer 2 Foyer 2 1

Registration

2 Plenary McEc 1 convention centre 3 GROUND FLOOR Speaker Ready Room

McEc 107

06 convention centre 102 1 F 101 105 o ye 108 104 103 r LEVEL yer s Fo Acces Balcony ary to Plen 1 111 112 110 109

November 15–19, 2015 | Melbourne, Australia 25 IPITA • IXA • CTS | www.melbourne2015.org YOUNG INVESTIGATORS ACTIVITIES

DuringtheIPITA-IXA-CTSJointCongress,theYoungInvestigatorandVanguardCommitteesofeach SectionarepleasedtoannounceawiderangeofactivitiesforCongressparticipantstoenjoy. ABSTRACT DRIVEN SESSION: YOUNG INVESTIGATORS BEST MINI-ORALS SESSION Date: November16,2015 time: 17:30–18:30 Thishighlycompetitivesessionwillhighlightthetop-ratedabstractssubmittedbyyounginvestigatorsof IPITA,IXA,andCTS.Thissessionprovidesauniqueopportunityforyounginvestigatorstoshowcase andpromotetheirresearch,whilstencouragingacuttingedgeandstimulatingdiscussionbetween younginvestigatorsfromallaroundtheworld. YOUNG INVESTIGATORS SOCIAL EVENING (full, stand by onsite only) Date: November16,2015 time: 18:30–20:30 Place: CargoHall(SouthWharf) cost: Freeofcharge(includedinregistrationfee)forstudents,traineesandfellows.Facultymentors, aswellasjuniorfacultyareverymuchwelcomeandencouragedtojointhisactivity.Ticketsare availableat$50perpersonUSD,including10%GST. IPITA YOUNG INVESTIGATOR COMMITTEE MORNING RUN YouareinvitedforamorningruneachdayduringtheCongress.Trainedanduntrainedrunnersare welcometojoina5KrunalongtheYarraRiverfollowingarouteselectedbylocaltransplant professionals. Each morning fromNovember16–19,2015 time: 06:30 Place: ClarendonStreetEntranceofMelbourneExhibitionCentre IPITA YIC DEBATE Pancreatic beta cell replacement therapy: What will we be doing in 2025? Date: November17,2015 time: 12:30–13:30 Place: MeetingRoom111-112

26 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SOCIAL ACTIVITIES

TheIPITA-IXA-CTS2015JointCongresswillofficiallygetstartedwithanOpeningReceptionatthe FoyeroftheMelbourneConventionandExhibitionCentre.Allregisteredparticipantsarecordially invitedtojoinusandcelebratetheofficialopening. OPENING RECEPTION Date: November15,2015 time: 18:00–19:30 Place: GroundFloor–MainFoyer1&2 cost: Includedinregistration

CONGRESS DINNER Date: November17,2015 time: 19:00–22:30 Place: MelbourneCricketGround cost: USD$110,00(GSTincl.)-ticketssolduntilSunday,November15th,18:00 CoacheswilldepartfromtheConventionCentreat18:30. Participantswishingtowalkwillbegivenamapatregistration. Melbourne cricket Ground

November 15–19, 2015 | Melbourne, Australia 27 IPITA • IXA • CTS | www.melbourne2015.org INFORMATION ON MELBOURNE Voted the most liveable city in the world, Melbourne is perfect for the explorer in all of us. Modern architecture and design is juxtaposed with heritage buildings reflecting Australia’s unique history. But beneath the surface, lies the true heart and soul of the city; laneways which snake the city grid to reveal cafes and bars, fashion houses, boutiques, innovative cuisine, galleries, theatres and museums.

28 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org CITY MAP 1 Melbourne convention and Exhibition centre 5 travelodge Docklands 2 crown Metropol Melbourne 6 Melbourne short stay Apartments 3 crown Promenade Hotel 7 Melbourne cricket Ground 4 crowne Plaza Melbourne 8 Hilton south Warf Hotel

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November 15–19, 2015 | Melbourne, Australia 29 IPITA • IXA • CTS | www.melbourne2015.org CITY TRANSPORTATION

city circle tramsruninbothdirectionsapproximatelyevery12minutesbetween10:00and18:00from SundaytoWednesdayandbetween10:00and21:00everyThursday,FridayandSaturday(except ChristmasDayandGoodFriday).TramtravelwithintheCBDandDocklandsisfree. Formoreinformationregardingtransportationvisit:www.ptv.vic.gov.au

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30 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org CITY TRANSPORTATION

Melbourne Visitor shuttle TheMelbourneVisitorShuttleisagreatwaytoseeMelbourne'sattractions.Thispopular,inexpensive serviceoperatesdailyevery30minutesfrom09:30to16:30pm(excludingChristmasDay).Thetrip takesapproximately90minutesandincludesaninformativeon-boardcommentaryasyoutravel aroundMelbourne.Travelonthebusserviceis$10AUDforupto2days. Checkthepagebelowfordetailsoftherouteandall13stops,plusanytemporarystopclosuresand routechanges. www.melbourne.vic.gov.au/shuttle

Public transport MYKi InterstateandoverseasvisitorscannowpurchasethemykiVisitorPack,fortravelonMelbourne'strain, tramandbusesthroughouttheirstay.ThemykiVisitorPackisnowavailablefromtheVisitorInformation CentreatFederationSquare,andthePTVHubSwanstonStreet,CornerofSwanstonandLittleCollins Streets.ThemykiVisitorPackisavailableforfullfare,concession,childandseniorvisitors. ThemykiVisitorPackincludes: n Amykismartcardpre-loadedwithenoughvalueforoneday'sZone1travel n Instructionsonhowtousemyki n AninnerMelbournetrammap n AmykiprotectivewalletdesignedbyrenownedcartoonistMarkKnight n Discountsat15attractionsworthmorethan$130AUDinsavings n AfullfaremykiVisitorPackcosts$14.00AUDincluding$8.00AUDmykimoney n Aconcession,childorseniorsmykiVisitorPackcosts$7.00AUD,including$4.00AUD mykimoney

November 15–19, 2015 | Melbourne, Australia 31 IPITA • IXA • CTS | www.melbourne2015.org PROGRAM-AT-A-GLANCE

Sunday - November 15th Monday - November 16th Tuesday - November 17th

PLENARY ROOM ROOM ROOM PLENARY ROOM ROOM ROOM PLENARY ROOM ROOM ROOM 1 110 111 112 1 110 109 111-112 1 110 109 111-112

IPITA IXA IPITA IXA Orals Mini-Orals Orals Mini-Orals Cell & 07:0007:30 Clinical Tolerance Experimental Tissue Pancreas and Zoonosis Islet Tx. XenoTx.; Islet Tx. Tolerance IPITA SOTA: IPITA SOTA: IXA SOTA: CTS SOTA: IPITA SOTA: IPITA SOTA: IXA SOTA: CTS SOTA: Monitoring of Topics in Progress in Stem Cell Tx. Modulating Integrating Genome Organ 08:0008:30 Beta Cell Pancreas Tx. Solid & Islet Bariatric Engineering Engineering Replacement Organ Dierentiation In!ammation Surgery into for XenoTx. Outcomes XenoTx. Diabetes Care

09:0009:3010:0010:3011:0011:3012:0012:3013:0013:3014:0014:3015:0015:3016:0016:3017:0017:3018:0018:3019:0019:3020:0020:30 Joint Joint Plenary I: Plenary II: Clinical New Trials Horizons Update

Coee Coee Break Break

IPITA Orals IPITA Orals IXA CTS IPITA Orals IPITA Orals IXA Orals CTS Orals Trends Progress and Islet Mesenchymal Islet Alt. Sources In!ammation Cellular and Progress Clinical XenoTx. Stromal Cells Auto Tx.: of Beta Cells: & Coagulation Encaps. in Clinical Outcomes in SOTA Xenoislet, Islet Tx. Pancreas Tx. Stem Cells, Tissue Engineering Debate: Islet Encap. JDRF / Pancreatic Lunch Break Helmsely Found. Lunch Break Beta Cell IPITA IPITA IXA / JDRF Aus. / Replacement Pre- Pre- Pre- GINER Therapy Symposium: Symposium: Symposium: Islet Pancreas Tx.: ABOi and IPITA IXA CTS Isolation Global Anti-HLA Symposium: Symposium: Symposium: and Tx.: Trends in Hyperimmune Registry Immuno- Roadblocks Special Where are Pancreas Tx. - Patient Part 1: Updates - suppression in Lectures We Now and Challenges Basic Science Pancreas & Tolerance Clinical Exhibit Area: Joint Poster Session Joint Poster Exhibit Area: Session Joint Poster Exhibit Area: Where are and & Laboratory & Islet Translation We Going? Opportunities IPITA Pre- Symposium: Coee Coee Islet and Break Break Whole IPITA Orals IPITA Orals IXA Orals CTS Orals IPITA Orals IPITA Orals IXA Orals CTS Orals Pancreas Tx: Getting Pancreas Genetic Stem Cells Modifying The Perfect Non-Gal Immunology Nursing & Beta Cells and Islet Tx.: Engineering; Bioengineer. Islet Part 2: Encapsul. Antibodies Allied Health to Survive: Antibodies, Methodology and Immunity - Clinical and Beta Cell Immunosupp. Preclinical Adaptive, Immunoiso. Survival and Work Innate, and Device IXA Life and Injury Outcomes Xenoimmun. Member Mechanisms Lecture IPITA Business IXA Business Meeting Meeting Young Investigators Joint Poster Best Session 1 Mini-Orals Session

Opening Reception Exhibit Area

Young Investigators Social Evening Congress Dinner at the Melbourne Cricket Ground

32 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org PROGRAM-AT-A-GLANCE

Wednesday - November 18th Thursday - November 19th

PLENARY ROOM ROOM ROOM PLENARY ROOM ROOM ROOM 1 110 109 111-112 1 110 109 111-112

WIT Breakfast Networking Session: 07:0007:30 Breakfast Biofabrication Astellas Workshop 1: Implantable Additive CTS SOTA: IPITA SOTA: IXA SOTA: IXA SOTA: CTS SOTA: IXA SOTA Biofabrication Regenerative 08:0008:30 Allo and Progress in Solid Organ What's New IPITA SOTA: Glycosylation Technologies Medicine, Auto- Tissue & Cell XenoTx: in Islet AutoTx. & non-Gal ARC Centres Aging immunity XenoTx. Surgical Tips Cell Therapy Xenoantigens for Excellence and Disease Joint

09:0009:3010:0010:3011:0011:3012:0012:3013:0013:3014:0014:3015:0015:3016:0016:3017:0017:3018:0018:3019:0019:3020:0020:30 Joint Presidential Plenary III: Session / Controlling Y.I. Awards / In"ammation 2017 Host & Coagulation Cities Presentations

Co!ee Co!ee Break Break

IPITA Orals IPITA Orals Prospects for CTS Orals IPITA Orals IPITA Orals IXA Orals CTS Orals Islet Pancreas and Clinical Islet Hepatocyte Topics in Islet Isolation Solid Organ Tissue Immunity Islet Tx. XenoTx. (CIX) Tx. Experimental and Survival XenoTx. (2) Engineering and Imaging, Otsuka and Clinical and Stem Cell Tolerance Biopsies Pharmaceuticals Islet Tx. Di!erentiation and Biomarkers

Lunch Break Lunch Break

IPITA IXA Biofabrication CTS Symposium: Symposium: Workshop 2: Symposium: Paul Lacy Pancreas & Zoonosis & Implantable Organ Lecture / Islet Allo-Tx.: Regulation Additive Degeneration, Islet Plenary Unifying Beta Biofabrication Mechanisms Cell Technologies of Organ Exhibit Area: Joint Poster Session Joint Poster Exhibit Area: Replacement ARC Centres Repair/Fibrosis Therapy for Excellence Co!ee Break IPITA Orals IPITA Orals IXA Orals CTS Orals Islet Quality Pancreas & Solid Organ Islet Cell Tx. Assessment Islet Donors: XenoTx. (1) - Misc. and Assessing Engraftment Risk and Optimizing Outcomes

CTS Business Meeting

Joint Poster Session 2

November 15–19, 2015 | Melbourne, Australia 33 IPITA • IXA • CTS | www.melbourne2015.org NOTES

34 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 15 IPITA IXA CTS Joint

13:00–16:15 Pre-symposium: islet isolation and transplantation: Plenary 1 Where are We Now and Where are We Going?

Chairs: Paul Johnson, United Kingdom and Bernhard J. Hering, United States SUNDAY 100 WHICHDONORANDISOLATIONFACTORSPREDICTSUCCESSFULISLET ISOLATIONSANDSUCCESSFULISLETTRANSPLANTOUTCOMES? Balamurugan N. Appakalai,UnitedStates 101 HOWGOODAREISLETTRANSPLANTSREALLYLONG-TERM? Francois Pattou,France 102 WHATLESSONSCANWELEARNFROMISLETAUTOTRANSPLANTATION? Melena D. Bellin,UnitedStates 14:30–15:30 BREAK

103 REIMBURSEMENTANDCOMMISSIONINGOFISLETTRANSPLANTATION– WHEREAREWENOW? Bernhard J. Hering,UnitedStates

13:00–16:15 Pre-symposium: Pancreas transplantation: Global trends in Room 110 Pancreas transplantation – challenges and Opportunities Chairs: Raja Kandaswamy, United States and Jon S. Odorico, United States 105 GLOBALTRENDSINPANCREASTRANSPLANTATION– REGIONALREPORTS:INTRODUCTION Raja Kandaswamy,UnitedStates 106 GLOBALTRENDSINPANCREASTRANSPLANTATION– REGIONALREPORTS:NORTHAMERICA Angelika c. Gruessner,UnitedStates 107 GLOBALTRENDSINPANCREASTRANSPLANTATION– REGIONALREPORTS:EUROPE Peter J. Friend,UnitedKingdom 108 GLOBALTRENDSINPANCREASTRANSPLANTATION– REGIONALREPORTS:AUSTRALIA Henry Pleass,Australia 110 GLOBALTRENDSINPANCREASTRANSPLANTATION– REGIONALREPORTS:ASIA Duck Jong Han,Korea PANELDISCUSSIONS

BREAK

November 15–19, 2015 | Melbourne, Australia 35 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 15 IPITA IXA CTS Joint

111 CHALLENGES:ADVANCESINDIABETICRX thomas W. Kay,Australia 112 CHALLENGES:IMPACTOFPANCREASTRANSPLANTATION ONSURVIVAL–PATIENTANDKIDNEYGRAFT Jonathan A. Fridell,UnitedStates 113 CHALLENGES:EMERGINGTHERAPIES thierry Berney,Switzerland

SUNDAY 114 CHALLENGES:RISKAVERSION,REIMBURSEMENTANDOTHERISSUES stephen t. Bartlett,UnitedStates PANELDISCUSSIONS

13:00 – 15:00 Pre-symposium: ABOi and Anti-HLA Hyperimmune Patient (Part 1) - Room 111 Basic science and Laboratory Chairs: Emanuele Cozzi, Italy and Kazuhiko Yamada, United States This symposium is proudly sponsored by CSL

120 INTRODUCTORYREMARKS Peter cowan,Australia 121 BASICSCIENCE&LABORATORY:CARBOHYDRATEFRONTIERS– NOVELTCELLRESPONSESTOCARBOHYDRATESAND IMPLICATIONSFORABOINCOMPATIBLETRANSPLANTATION Mauro s. sandrin,Australia 122 BASICSCIENCE&LABORATORY:ANIMALMODELSOFHYPERACUTE/ ACCELERATEDACUTEREJECTION David Nikolic-Paterson,Australia 123 BASICSCIENCE&LABORATORY:UNDERSTANDINGTHEMATCHMAKER PROGRAMANDTHEAPPLICATIONOFEPLETMATCHINGTOCLINICALTRANSPLANTATION Rhonda Holdsworth,Australia BREAK(PART2CONTINUEDAT15:20-seepage38)

36 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV 15. IPITA IXA CTS Joint

14:00–17:00 Pre-symposium: islet and Whole Pancreas transplantation: Room 112 Nursing & Allied Health

Chairs: Toni Radford, Australia and Rob J. R. Crookston, United Kingdom SUNDAY This symposium is proudly sponsored by OTA

125 ISLETANDWHOLEPANCREASTRANSPLANTATION Rob J.R. crookston,UnitedKingdom 126 AUSTRALIA’SNATIONALLYFUNDEDCENTRE,ISLETTRANSPLANT PROGRAM-THEJOURNEYTOGOVERNMENTFUNDINGINAUSTRALIA toni Radford,Australia 127A STANDARDSOFCAREINISLETTRANSPLANTNURSING– ANINTERNATIONALPROJECT Joan c. McElroy,UnitedStates 127B STANDARDSOFCAREINISLETTRANSPLANTNURSING– ANINTERNATIONALPROJECT Louise Berry,UnitedStates 128 WHOLEPANCREASTRANSPLANTATION-THEEXPERIENCE, PROGRESSANDCHANGESOVER25YEARS,FROMAPANCREAS TRANSPLANTNURSECOORDINATOR Nancy A. Radke,UnitedStates 129 INTERACTIVESESSION-LIMITATIONSANDBARRIERSOFISLET ANDPANCREASTRANSPLANTSWITHGROUPDISCUSSION:ISLET Kathy M. Howe,Australia 130 INTERACTIVESESSION-LIMITATIONSANDBARRIERSOFISLETAND PANCREASTRANSPLANTSWITHGROUPDISCUSSION:PANCREAS Paul Robertson,Australia

BREAK

VIDEOONISLETANDPANCREASRECIPIENTSAROUNDTHEWORLD DISCUSSINGTHEIRTRANSPLANTEXPERIENCE 131 FEEDBACKANDDISCUSSIONOFVIDEO toni Radford,Australia 132 MODELTOINCREASEITPATIENTRECRUITMENTANDAWARENESS INOXFORDUK Rob J.R. crookston,UnitedKingdom 133 ANUPDATEOFTHELATESTNEWSINTREATMENTOFT1D Pratik choudhary,UnitedKingdom CLOSINGREMARKS

November 15–19, 2015 | Melbourne, Australia 37 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 15 IPITA IXA CTS Joint

15:20–17:15 Pre-symposium: ABOi and Anti-HLA Hyperimmune Patient (Part 2) - clinical Room 111 135 CLINICAL:ABOINCOMPATIBLETRANSPLANTATIONWITHOUT ANTIBODYREMOVAL-WHENISABOANTIBODYREMOVALNEEDED? Rosemary Masterson,Australia 136 CLINICAL:CURRENTPROGRESSANDACHIEVEMENTSIN ABO-INCOMPATIBLEKIDNEYTRANSPLANTATIONINKOREA Jaeseok Yang,Korea SUNDAY 137 CLINICAL:THEROLEOFTHENATIONALPAIREDKIDNEYEXCHANGE PROGRAMINLIVEDONOROPTIONSFORABOINCOMPATIBLE TRANSPLANTATIONANDANTI-HLAHYPERIMMUNEPATIENTS Paolo Ferrari,Australia 138 CLINICAL:ABOINCOMPATIBILITYANDGRAFTACCOMMODATION: POTENTIALSTRATEGYTOPREVENTACUTE/CHRONICANTIBODYMEDIATEDREJECTION takaaki Kobayashi,Japan 139 CLOSINGREMARKS Peter cowan,Australia

18:00–19:30 Opening Reception FOYER 1 & 2

38 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org NOTES

November 15–19, 2015 | Melbourne, Australia 39 IPITA • IXA • CTS | www.melbourne2015.org NOTES

40 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

07:00–08:00 Orals: Mini-Orals: clinical Pancreas and islet transplantation ROOM 110 Chairs: Titus Augustine, United Kingdom and Melena D.Bellin, United States 200 PANCREASTRANSPLANTATIONINDUCTIONWITHRABBIT ANTITHYMOCYTEGLOBULIN+/-RITUXIMABANDEARLYSTEROID WITHDRAWAL:EXPERIENCEWITH>500RECIPIENTS Jonathan A. Fridell,UnitedStates 201 THEASSESSMENTOFEX-VIVOHUMANPANCREATAUSING MAGNETICRESONANCEIMAGING Hussein A. Khambalia,UnitedKingdom 202 CANPOST-TRANSPLANTC-PEPTIDEBEUSEDASANINDICATOR

OFPANCREASGRAFTFAILURE? MONDAY Jonathan A. Fridell,UnitedStates 203 PANCREATAFROMPEDIATRICDONORSRESTOREINSULIN INDEPENDENCEINADULTTYPE1DIABETICRECIPIENTS Paola Maffi,Italy 204 SEVERELOWERLIMBEPIDERMALNERVEFIBERLOSSINDIABETIC NEUROPATHYISNOTREVERSEDBYLONG-TERMNORMOGLYCEMIA FOLLOWINGSIMULTANEOUSPANCREASANDKIDNEYTRANSPLANTATION Frantisek saudek,CzechRepublic 205 OCULARCOLORDOPPLERULTRASOUND(OCDUS)ASSESSMENTOF BLOODFLOWVELOCITIESCHANGESINCENTRALRETINALARTERY (CRA)ANDVEIN(CRV)AFTERISLETTRANSPLANTATIONINTYPE1 DIABETICPATIENTS:CORRELATIONWITHGRAFTFUNCTIONINALONGTERMSTUDY Paola Maffi,Italy 206 SUCCESSFULISLETOUTCOMESUSINGAUSTRALIAWIDEDONORS: ANATIONALCENTREEXPERIENCE Wayne J. Hawthorne,Australia 207 CLINICALISLETALLOGRAFTTRANSPLANTATIONVIAMINI-LAPAROTOMY: THEBENEFITOFULTRASOUNDGUIDEDTRANSVERSUSABDOMINISPLANE(TAP) James V. Harmon Jr.,UnitedStates 208 CHOLESTATICLIVERINJURYAFTERBILIARYRECONSTRUCTIONIMPAIRS TRANSPLANTEDISLETVIABILITYANDFUNCTIONDUETOOXIDATIVESTRESS Naoaki sakata,Japan 209 CIRCULATINGMIRORNA375LEVELSBEFOREISLETAUTOTRANSPLANTATION INVERSELYCORRELATEDWITHPOST-DIGESTIONISLETYIELD Morihito takita,UnitedStates

November 15–19, 2015 | Melbourne, Australia 41 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

07:00–08:00 Orals: tolerance, Zoonosis Room 109 Chairs: Megan Sykes, United States and Linda Scobie, United Kingdom 212 CO-STIMULATIONBLOCKADEINDUCINGTOLERANCETOPORCINE ISLETXENOGRAFTSPRODUCEDFOXP3+REGULATORYTCELLS WITHHIGHIL-10PRODUCTIONANDEXPRESSINGMHCCLASSII THATWERECAPABLEOFDOMINANTTOLERANCE Min Hu,Australia 213 ABO-TOLERANCEINAMURINEMODELOFABO-INCOMPATIBLE HEARTTRANSPLANTATION(ABOIHTX) Lori J. West,Canada 214 CRYOPRESERVEDREGULATORYTCELLS(TREGS)ISOLATEDFROM DISCARDEDHUMANTHYMUSPOTENTLYSUPPRESSALLOGENEIC ANDXENOGENEICIMMUNERESPONSESAFTEREXPANSION Esme Dijke,Canada 215 MICROBIOLOGICALSCREENINGOFWILD-TYPEANDGENETICALLY ENGINEEREDPIGSANDTRANSPLANTRECIPIENTSINPIGTO MONDAY NON-HUMANPRIMATEXENOTRANSPLANTATION Joachim Denner,Germany 216 NON-IDENTICALPERVPROFILEOBSERVEDINCLONEDPIGS claire L. crossan,UnitedKingdom 217 ANTIBODYSTUDIESUSINGVIRUSPARTICLESDISPLAYING XENO-REACTIVEANTIGENS;ALPHA-GAL,NEU5GCANDSDA-LIKE CARBOHYDRATESTRUCTURES Yasuhiro takeuchi,UnitedKingdom 218 IMPACTOFPERVINFECTIONONTHEPIGTRANSCRIPTOME Ralf R. tönjes,Germany

08:00–09:00 state-of-the-Art Workshop: Monitoring of Beta cell Replacement Outcomes Plenary 1 Chairs: Thierry Berney, Switzerland and Peter A Senior, Canada 220 ADVANCESINMRISLETIMAGING Frantisek saudek,CzechRepublic 221 BIOMARKERSOFISLETGRAFTINJURY Bashoo Naziruddin,UnitedStates 222 PET/SPECTIMAGINGOFISLETS Fouad R. Kandeel,UnitedStates

42 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

08:00–09:00 state-of-the-Art Workshop: topics in Pancreas transplantation Room 110 Chairs: Stephen T. Bartlett, United States and Raja Kandaswamy, United States 225 CRITICALREVIEWOFRESULTSOFSTEROIDAVOIDANCE/WITHDRAWAL INPANCREASTRANSPLANTATION Peter J. Friend,UnitedKingdom 226 IMMMUNOSUPPRESSIVEOPTIONSINPANCREASTRANSPLANTATION Peter G. stock,UnitedStates 227 PANCREASUNDERUTILIZATION:EXPANDSTUDY stefan A. Farkas,Germany 228 EXPANDINGINDICATIONSFORPANCREASTRANSPLANTATION

Jonathan A. Fridell,UnitedStates MONDAY

08:00–09:00 state-of-the-Art Workshop: Progress in solid Organ Xenotransplantation Room 109 Chairs: David K.C. Cooper, United States and Wayne J. Hawthorne, Australia 230 HEART Muhammad M. Mohiuddin,UnitedStates 231 PROGRESSINKIDNEYXENOTRANSPLANTATION Hayato iwase,UnitedStates 232 LIVER Burcin Ekser,UnitedStates 233 LUNG Richard N. Pierson iii,UnitedStates

08:00–09:00 state-of-the-Art Workshop: stem cell transplantation & Differentiation Room 111-112 Chair: Ed G. Stanley, Australia 235 HEPATOCYTESTEMCELLS Roberto Gramignoli,Sweden 236 CARDIACCELLTRANSPLANTATION James chong,Australia 237 HEMATOPOIETICSTEMCELLINDUCTION:INSIGHTSFROMZEBRAFISH Peter D. currie,Australia

09:00–10:30 Plenary: clinical trials Update Plenary 1 Chairs: Joseph R. Leventhal, United States and Alan O. Trounson, Australia 240 CELLULARIMMUNOTHERAPY-THEONESTUDY Edward K. Geissler,Germany 241 CLINICALTRIALOFENCAPSULATEDNEONATALPORCINEISLET XENOTRANSPLANTATION shinichi Matsumoto,Japan 242 CLINICALTRIALSFORSTEMCELL-BASEDREGENERATIVEMEDICINE silviu itescu,Australia

November 15–19, 2015 | Melbourne, Australia 43 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

10:30–11:00 coffee Break Foyer 1 & 2

11:00–12:30 Orals: trends and Progress in clinical islet transplantation Plenary 1 Chairs: Eelco E. de Koning, Netherlands and John Casey, United Kingdom 245 TWENTYYEARSOFALLOGENEICISLETTRANSPLANTATIONFOR TYPE1DIABETESINASINGLECENTER:TRENDSANDPROGRESSES thierry Berney,Switzerland 246 ISLETALLOTRANSPLANTATION:SINGLECENTREEXPERIENCE1989-2015 Paola Maffi,Italy 247 FIVEYEAROUTCOMESFROMTHEAUSTRALIANMULTICENTRE TRIALOFISLETTRANSPLANTATION Philip J. O'connell,Australia 248 ISLETTRANSPLANTATIONINTHEUNITEDKINGDOM-DATAFROM THEUKTRANSPLANTREGISTRY John casey,UnitedKingdom

MONDAY 249 IMPROVEMENTSINMULTIPLECARDIOVASCULARBIOMARKERS FOLLOWINGISLETCELLTRANSPLANTATIONINPATIENTSWITHTYPE1DIABETES Kirstie K. Danielson,UnitedStates 250 SPECTRAL-DOMAINOPTICALCOHERENCETOMOGRAFYANDORBITAL COLOR-DOPPLERULTRASOUNDINTYPE1DIABETESAFTERISLETTRANSPLANTATION Paola Maffi,Italy 251 EFFECTOFGCSFANDGLP1AGONISTONLONG-TERMHUMAN ISLETALLOGRAFTSURVIVAL camillo Ricordi,UnitedStates 252 IMPACTONACCESSTOEVENTUALRENALTRANSPLANTATIONOF ALLOGENICISLETTRANSPLANTATIONFROMMULTIPLEHLA UNMATCHEDDONORSINNONUREMICPATIENTS François Pattou,France 253 PRIMARYGRAFTFUNCTIONPREDICTS10YEAROUTCOMEAFTER ISLETTRANSPLANTATION François Pattou,France 254 THEIMPACTOFISLETCELLTRANSPLANTATIONONQUALITYOFLIFE INPATIENTSWITHSEVEREHYPOGLYCAEMIAUNAWARENESS Patricia F. Anderson,Australia 255 TENYEARFOLLOWUPAFTERISLETALLOTRANSPLANTATIONINPATIENTS WITHBRITTLETYPE1DIABETES:THEUNIVERSITYOFCHICAGOEXPERIENCE Piotr Witkowski,UnitedStates

44 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

11:00–12:30 Orals: Progress and clinical Outcomes in Pancreas transplantation Room 110 Chairs: Mark S. Cattral, Canada and Yogish C. Kudva, United States 260 IMMUNOPROTECTIVEIMPACTOFTHEKIDNEYINSPKTRANSPLANTS- PROCEEDWITHLIVEDONORKIDNEYORWAITFORSPK? Erik B. Finger,UnitedStates 261 IMPACTOFDUODENALCUFFINFLAMMATIONONOUTCOMEAFTER CLINICALPANCREASTRANSPLANTATION–ASURVEYOF ACOMPREHENSIVEFOLLOW-UPSTRATEGYINCLUDINGSERIAL PROTOCOLBIOPSYOFTHEDUODENALCUFF Ali-Reza Biglarnia,Sweden

262 RECIPIENTANDPANCREASGRAFTSURVIVALAFTER MONDAY SIMULTANEOUSKIDNEY-PANCREASTRANSPLANTATION INAUSTRALIAANDNEWZEALAND:ACOHORTSTUDY1984-2014 Patrick J. Kelly,Australia 263 SUPERIORPANCREATICALLOGRAFTSURVIVALINRECIPIENTS OFSIMULTANEOUSPANCREASANDKIDNEYTRANSPLANTS: ANUPDATEDANALYSISOFTHEUNOSDATASET Matthew cooper,UnitedStates 264 LONGTERMOUTCOMEOF83SPLKTRANSPLANTSATASINGLECENTER stephen t. Bartlett,UnitedStates 265 WHYAREPANCREASTRANSPLANTVOLUMESINTHE UNITEDSTATESDECLINING? Jonathan A. Fridell,UnitedStates 266 10YEAREXPERIENCEUSINGASTEROIDFREETHREEDRUG MAINTENANCEIMMUNOSUPPRESSIONREGIMENFORPANCREAS TRANSPLANTALONE:COMPARISONOFINDUCTIONWITHRABBIT ANTITHYMOCYTEGLOBULIN+/-RITUXIMAB Jonathan A. Fridell,UnitedStates 267 SUPRA-PHYSIOLOGICALHAEMODYNAMICOPTIMISATIONIMPROVES SHORT-TERMOUTCOMESFOLLOWINGSIMULTANEOUSPANCREAS ANDKIDNEYTRANSPLANTATION:ARANDOMISEDCLINICALTRIAL(NCT01619904) Hussein A. Khambalia,UnitedKingdom 268 THEIMPACTOFCENTERVOLUMEONOUTCOMEOFPANCREASTRANSPLANTS Angelika c. Gruessner,UnitedStates 269 SURVIVALBENEFITOFPANCREASAND/ORKIDNEYTRANSPLANTATION FORDIABETICPATIENTSINTHEUNITEDSTATES Rainer W.G. Gruessner,UnitedStates

November 15–19, 2015 | Melbourne, Australia 45 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

11:00–12:30 Orals: islet Xenotransplantation Room 109 Chairs: Greg S. Korbutt, Canada and Shinichi Matsumoto, Japan 275 ANTI-GALIGMRESPONSEWHICHISSUPPRESSEDBYANTI-CD154, NOTBYANTI-CD40,ISASSOCIATEDWITHEARLYGRAFTFAILUREIN INTRAPORTALPORCINEISLETXENOTRANSPLANTATION Hee Jung Kang,Korea 276 LONG-TERMSURVIVALOFGENETICALLYMODIFIEDPORCINE NEONATALISLETXENOGRAFTSINBABOONS Wayne J. Hawthorne,Australia 277 PRECLINICALSTUDIESONPORCINEISLETMACROENCAPSULATION INNON-HUMANPRIMATES Barbara Ludwig,Germany 278 OVEREXPRESSIONOFHUMANHO-1ORSTNF-αR-FCINADULT PORCINEISLETSUSINGADENOVIRALTRANSDUCTIONOR TRANSGENICPIGSPROLONGSISLETXENOGRAFTSURVIVALBY SUPPRESSINGBOTHEARLYAPOPTOSISANDINFLAMMATION MONDAY Ji-Jing Yan,Korea 279 PERV(PORCINEENDOGENOUSRETROVIRUS)INTEGRATIONAND EXPRESSIONINPANCREATICISLETSANDOTHERTISSUESINNEONATAL ANDADULTPIGS Nizar i. Mourad,Belgium 280 PLASMAMICRORNA-375–ASINGLETESTTOQUANTITATEINJURY TOPORCINEISLETGRAFTSANDTODIAGNOSEACCELERATED PORCINEISLETGRAFTLOSSINNONHUMANPRIMATES? Raza A. Naqvi,UnitedStates 281 ANEWBIOINFORMATICSANALYSISREVEALSINTESTINALINFECTION ASAPOSSIBLECAUSEOFINTRAHEPATICGRAFTREJECTIONIN NON-HUMANPRIMATEPORCINEISLETXENOTRANSPLANTATION Hyun Je Kim,Korea 282 ANTI-CD2PRODUCINGPIGXENOGRAFTSEFFECTLOCALIZEDDEPLETION OFHUMANTCELLSINAHUMANIZEDMOUSEMODEL Jamie L. Brady,Australia 283 IMPROVINGPORCINEISLETYIELDWITHNEWRECOMBINANTCLASSI(RC1) ANDCLASSII(RC2)COLLAGENASESINCOMBINATIONWITHBPPROTEASE, ANANIMAL-FREEENZYMEMIXTURE Balamurugan N. Appakalai,UnitedStates 284 TRANSPLANTATIONOFALGINATE-BASEDMICROENCAPSULATED NEONATALPORCINEISLETSINDIABETES Azadeh Hosseini-tabatabaei,Canada

46 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

11:00–12:30 Orals: Mesenchymal stromal cells Room 111-112 Chair: Johnny Huard, United States 290 BONEMARROWDERIVEDMSCSREGULATESINFLAMMATORY MICROENVIRONMENTANDAMELIORATESRATSFROMDIABETIC NEPHROPATHYBYINHIBITINGACTIVATIONOFMACROPHAGES Jingping Liu,People'sRepublicofChina 291 HEMATOPOIETICSTEMCELLMOBILIZATIONANDCOLLECTION INTHERHESUSMAQAQUE:THEEFFECTOFHIGHDOSESTEMCELLFACTOR James V. Harmon Jr.,UnitedStates 292 IMAGINGOFIRONNANO-PARTICLELABELLEDMESENCHYMAL

STEMCELLSINOVINEHETEROTOPICKIDNEYTRANSPLANTATION MONDAY Bron D. Lett,Australia 293 GENEMICROARRAYCOMPARATIVEANALYSISOFINTERFERON-GAMMA ANDINTERLEUKIN-17APRECONDITIONEDHUMANMESENCHYMALSTEMCELLS Kisha Nandini sivanathan,Australia 294 COMPARINGWITHDIFFERENTREGIMENSOFHAPLO-IDENTICAL HEMATOPOIETICSTEMCELLTRANSPLANTATIONINPATIENTSWITH ACUTEMYELOIDLEUKEMIA Xin Wang,People'sRepublicofChina 295 MSCSCONDITIONEDMEDIUMINHIBITSTNF-α INDUCEDHUMAN UMBILICALVEINENDOTHELIALCELLSINJURY Meimei shi,People'sRepublicofChina 296 SENESCENCEOFCRYOPRESERVEDUMBILICALCORDMESENCHYMAL STEMCELLSINPLATELETLYSATECONTAININGMEDIUM Jeanne A. Pawitan,Indonesia 297 MSCSATTENUATEHIGHGLUCOSE-INDUCEDOXIDATIVESTRESS ANDREDUCEMITOCHONDRIALDYSFUNCTIONINHUMANUMBILICAL VEINENDOTHELIALCELLS Yujia Yuan,People'sRepublicofChina 298 INTRAVENOUSINJECTIONOFHUMANMESENCHYMALSTEMCELLS AMELIORATEDEARLYRENALDAMAGEINDIABETICRHESUSMONKEYMODEL Xingxing An,People'sRepublicofChina 299 PERIPHERALINFUSIONOFHUMANUMBILICALCORDMSCRESCUES MONKEYSFROMLETHALACUTELIVERFAILUREBYINHIBITINGTHE ACTIVATIONOFCIRCULATINGMONOCYTES Gang Guo,People'sRepublicofChina

12:30–13:30 Lunch Break (on own) - Exhibits & Poster Viewing

November 15–19, 2015 | Melbourne, Australia 47 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

12:30–13:30 Lunch symposium: islet Encapsulation Room 109 Chair: Albert Hwa, United States This symposium is proudly sponsored by the JDRF / Helmsley Foundation / JDRF Australia / Giner

300 INTRODUCTION/OVERVIEW Albert Hwa,UnitedStates 301 MACROENCAPSULATION-IMMUNEPROTECTION,FIBROSISVSVASCULARIZATION, DELAYEDINSULINKINETICS tom Loudovaris,Australia 302 LAYER-BY-LAYERENCAPSULATIONOFBIOACTIVEPOLYMERSFORILSETENCAPSULATION cherie L. stabler,UnitedStates 303 OXYGENLIMITATION-ENGINEERINGSOLUTIONSFORDIFFERENTSCENARIOS Klearchos K. Papas,UnitedStates MONDAY Lunchboxes will be offered to symposium attendees on a first-come, first-served basis

13:30–15:00 symposium: Registry Updates - Pancreas & islet Plenary 1 Chairs: Paul Johnson, United Kingdom and Peter G. Stock, United States 305 IPTRUPDATE Angelika c. Gruessner,UnitedStates 306 CITRUPDATE Franca B. Barton,UnitedStates 307 CITUPDATE Bernhard J. Hering,UnitedStates 308 DEREK GRAY AWARD LEctURE: isLEt tRANsPLANtAtiON isOLAtiON sarah E. cross,UnitedKingdom

13:30–15:00 symposium: immunosuppression & tolerance Room 109 Chairs: Francesco L. Ierino, Australia and Megan Sykes, United States This session is proudly sponsored by Novartis

310 TRANSGENICLOCALIMMUNOSUPPRESSIONFORXENOTRANSPLANTATION Andrew M. Lew,Australia 311 TOLERANCEINXENOTRANSPLANTATION-INSIGHTSFROMALLO Joseph R. Leventhal,UnitedStates 312 USINGREGULATORYCELLSFORXENOTRANSPLANTATION shounan Yi,Australia

48 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

13:30–15:00 symposium: Roadblocks in clinical translation Room 111-112 Chairs: Robert Fisher, United States and Patrick T. Coates, Australia 315 MESENCHYMALSTEMCELLSFORACUTESTROKE Robert Deans,UnitedStates 316 NEURONALCELLS Evan Y. snyder,UnitedStates 317 PROBLEMSWITHHEPATOCYTES Robert Fisher,UnitedStates

15:00–15:30 coffee Break Foyer 1 & 2

15:30–17:00 Orals: Getting Beta cells to survive: Plenary 1 MONDAY Beta cell survival and injury Mechanisms Chairs: Bashoo Naziruddin, United States and Daniel Brandhorst, United Kingdom 320 TREATMENTWITHIL-1RECEPTORANTAGONISTREDUCESAMYLOID BETA-CELLTOXICITYINHUMANISLETS:IMPLICATIONSINCLINICAL ISLETTRANSPLANTATION Ziliang Ao,Canada 321 PRECONDITIONINGWITHDIAZOXIDEREDUCESISCHEMIA-REPERFUSION INJURYTORODENTANDNON-HUMANPRIMATEPANCREATAANDISLETS Yong Wang,UnitedStates 322 THEPRESENCEOFDIABETESAUTOANTIGENSINMICROPARTICLES DERIVEDFROMHUMANISLETS craig P. Hasilo,Canada 323 WITHAFERINAPREVENTSISLETDAMAGECAUSEDBYIBMIR: MICRORNA375ANALYSIS Mazhar A. Kanak,UnitedStates 324 ANTI-AGINGGLYCOPEPTIDEPROTECTSHUMANISLETSAGAINST TACROLIMUS-RELATEDINJURYANDFACILITATESENGRAFTMENT  Boris L. Gala-Lopez,Canada 325 IDENTIFYINGMIRNASASSOCIATEDWITHHUMANISLETGRAFT REJECTIONINAHUMANIZEDMOUSEMODEL Zhiguang Guo,UnitedStates 326 PANCREATICBETA-CELLEXPRESSIONOFIFN-GAMMA-INDUCIBLE PROTEIN10(IP-10/CXCL10)INRESPONSETOISLETCELLSTRESS ISREQUIREDFOREARLYISLETGRAFTLOSSOFFUNCTION Michael c. Lawrence,UnitedStates 327 CO-TRANSPLANTATIONWITHMESENCHYMALSTEMCELLSFROM CHRONICPANCREATITISPATIENTSPROTECTSISLETSFROM DEATHAFTERTRANSPLANTATION Hongjun Wang,UnitedStates 328 PEROXISOMEPROLIFERATOR-ACTIVATEDRECEPTOR-GAMMAAGONIST, PIOGLITAZONEPREVENTSEARLYGRAFTLOSSINCANINEPANCREATIC ISLETAUTO-TRANSPLANTATION Yoh Asahi,Japa

November 15–19, 2015 | Melbourne, Australia 49 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

15:30–17:00 Orals: Pancreas and islet transplantation: Room 110 Antibodies, immunosuppression, and Outcomes Chairs: Kenneth L. Brayman, United States and Jose Oberholzer, United States 330 THEIMPACTOFDONORSPECIFICANTIBODIESONREJECTIONAND GRAFTSURVIVALAFTERPANCREASTRANSPLANTATION Jerome M. Laurence,Canada 331 CONVERSIONFROMTWICEDAILYTACROLIMUSTOONCEDAILY MODIFIEDRELEASETACROLIMUSINSTABLEPANCREASTRANSPLANT RECIPIENTS–ASAFETYSTUDY Jerome M. Laurence,Canada 332 OUTCOMEOFPANCREASAFTERISLET(PAI)TRANSPLANTATION– AREPORTOFTHEINTERNATIONALPANCREASTRANSPLANTREGISTRY(IPTR) Rainer W.G. Gruessner,UnitedStates 333 INCIDENCE,OUTCOMESANDPREDICTORSOFDENOVODONOR SPECIFICANTIBODYINPANCREASTRANSPLANTATION

MONDAY Robert R. Redfield iii,UnitedStates 334 VIRTUALCROSSMATCHINGFORPANCREASTRANSPLANTATIONIS IMMUNOLOGICALLYSAFEANDREDUCESORGANISCHAEMICTIME Petros Yiannoullou,UnitedKingdom 335 VIRTUALHLACROSSMATCHINGUSINGSINGLEANTIGENBEADLUMINEX ASSAYSSAFELYEXPEDITESTRANSPLANTATIONOFIMPORTEDPANCREATA Brian c. Eby,UnitedStates 336 SIROLIMUSWITHTACROLIMUSDIDNOTPROLOGEDWOUNDHEALINGIN PANCREASANDKIDNEYTRANSPLANTATION–RANDOMIZEDSINGLE CENTERSTUDYWITH5–YEARFOLLOW-UP Frantisek saudek,CzechRepublic 337 TREATMENTOFTHEHIGHLEVELOFDONORSPECIFICANTIBODIES FORSUCCESSFULISLETALLOTRANSPLANTATION Piotr Witkowski,UnitedStates 338 SIROLIMUSRESCUEMAINTENANCETHERAPYFORREFRACTORY PANCREASREJECTION Nancy A. Radke,UnitedStates 339 ANTIBODYMONITORINGINPANCREASTRANSPLANTATION: SUBCLINICALREJECTIONINPROTOCOLBIOPSIESINPATIENTSWITHDSAANTIBODIES Pablo D. Uva,Argentina 340 DOESCARDIACRISKQUANTIFICATIONHAVEAROLEINASSESSMENT FORPANCREASTRANSPLANTATION? Hussein A. Khambalia,UnitedKingdom

50 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM -NOV. 16 IPITA IXA CTS Joint

15:30–17:00 Orals: Genetic Engineering; Methodology Room 109 Chairs: Eckhard Wolf, Germany and Curie Ahn Ahn, Korea 345 TARGETEDGENOME-WIDEINACTIVATIONOFPORCINE ENDOGENOUSRETROVIRUSACTIVITIES(PERVs) Luhan Yang,UnitedStates 346 SIX-GENEMULTI-TRANSGENICPIGSSERVEASSOURCEANIMALS TOADDRESSINNATEANDCHRONICREJECTION,INFLAMMATION,AND COAGULOPATHYINORGANXENOGRAFTS David Ayares,UnitedStates 347 THEIMMUNEPROFILEOFDONORPIGSWITHUBIQUITOUSEXPRESSIONOFLEA29Y

Andrea Bähr,Germany MONDAY 348 IMMUNEPHENOTYPEANDIGGCHARACTERISTICSOFNEU5GCAND ALPHA-1-3-GALDOUBLEKNOCK-OUTPIGS Apolline salama,France 349 TARGETEDTRANSGENEINSERTIONINPIGCELLSUSINGAHIGH FIDELITYCRISPRSYSTEM Nella Fisicaro,Australia 350 EFFICIENTPRODUCTIONOFGGTA1-/-/Fah+/-KNOCKOUTPIGSBY CRISPR/Cas9ANDSOMATICCELLNUCLEARTRANSFER Bjoern Petersen,Germany 351 AHIGH-THROUGHPUTMETHODFORPIGXENOANTIGENSCREENING BASEDONCRISPR/Cas9LENTIVIRALLIBRARIES Lisha Mou,People'sRepublicofChina 352 GENERATIONOFTRANSGENICPIGSEXPRESSINGATCELL-DEPLETING ANTI-CD2MONOCLONALANTIBODY Evelyn salvaris,Australia 353 EFFICIENTGENERATIONOFATRIPLEKNOCKOUT(GGTA1/CMAH/ASGR1) OFXENORELEVANTGENESINPIGFIBROBLASTS Bjoern Petersen,Germany 354 TARGETINGTISSUEFACTORANDGGTA1EXPRESSIONINPIGS FORIMPROVEDXENOGRAFTSURVIVAL Bjoern Petersen,Germany 355 DOSE-RANGINGSTUDYOFACOMBINATIONDRUGWITH CYCLOPHOSPHAMIDE(CYTOXAN)ANDFLUDARABINEINNON-HUMANPRIMATES Du Yeon shin,Korea 356 ANALYSESOFHUMAN,MONKEY,ANDPIGIMMUNOLOGICALLY-RELATED PROTEINSPROVIDEINSIGHTINTOXENOTRANSPLANTATION Ying Lu,People'sRepublicofChina

November 15–19, 2015 | Melbourne, Australia 51 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 16 IPITA IXA CTS Joint

15:30–17:00 Orals: stem cells Bioengineering, and Preclinical Work Room 111-112 Chairs: Camillo Ricordi, United States and Ed G. Stanley, Australia 360 EFFECTSOFINTERLACINGENDOTHELIALCELLSONIN-VITRO DIFFERENTIATIONOFINDUCEDPLURIPOTENTSTEMCELLEMBRYOID BODIESINTOHEPATOCYTE-LIKECELLS Robert Fisher,UnitedStates 361 GENETHERAPYFORDIABETES:REVERSALOFDIABETESINTHE HUMANISEDFRGMOUSEMODEL Ann M. simpson,Australia 362 BIOENGINEEREDINSULIN-SECRETING3DCONSTRUCTS Ekaterine Berishvili,Switzerland 363 DEVELOPINGBONEMARROWTRANSPLANTANDLENTIVIRAL VECTORSTOTREATFRIEDREICHATAXIA sze Hwee Ong,Australia 364 INSITUOXYGENBIOMATERIALFOREXTRAHEPATICISLETTRANSPLANTATION

MONDAY Maria M. coronel,UnitedStates 365 THERAPEUTICINFUSIONOFPARTIALLYHLA-MATCHEDTHIRD-PARTY VIRUS-SPECIFICTCELLS(VST)FORTREATMENTOFREFRACTORY VIRALINFECTIONINHAEMATOPOIETICSTEMCELLTRANSPLANT(HSCT) ANDRENALTRANSPLANTPATIENTS Barbara P. Withers,Australia 366 EVALUATIONOFPHENOTYPE,MIGRATION,ENGRAFTMENTANDSAFETY OFHUMANCORDBLOODDERIVEDEX-VIVOCREATEDDI-CHIMERICCELLS INNODSCIDMOUSEMODEL:APRELIMINARYSTUDY Joanna cwykiel,UnitedStates 367 CELLTHERAPYUSINGBONEMARROWDERIVEDCELLFORLIVER CIRRHOSISPATIENT shuji terai,Japan 368 ESTABLISHMENTOFFEEDERFREECULTUREOFNAïVESTATE OFPORCINEIPSCELLS Hisashi sahara,Japan 369 GMPISOLATIONANDQUALITYASSESMENTONHUMANAMNION EPITHELIALCELLFORCLINICALTHERAPIES Roberto Gramignoli,Sweden 370 APPLICATIONOFAPROMINENTOXYGEN-PERMEABLEBAGFOR SHORT-TIMEHEPATOCYTEPRESERVATIONPRIORTOTRANSPLANTATION Kengo Fukuoka,Japan

17:00–17:30 iPitA BUsiNEss MEEtiNG (association info on page 7) Room 110

52 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM -NOV. 16 IPITA IXA CTS Joint

17:30–18:30 Orals: Young investigators Best Mini-Orals session Penary I Chairs: Bradley P. Weegman, United States, Sarah E. Cross, United Kingdom, and Chris Burlak, United States 375 LONG-TERMSURVIVALOFPIG-TO-PRIMATERENAL XENOTRANSPLANTUSINGCOSTIMULATION-BLOCKADEIMMUNOSUPPRESSION Laura B. Higginbotham,UnitedStates 376 PROLONGEDSURVIVALOFPORCINESKINONBABOONSFOLLOWING ADMINISTRATIONOFPORCINECELLSEXPRESSINGHUMANCD47 Aseda tena,UnitedStates 377 RESTRUCTURINGOFAPANCREASTRANSPLANTPROGRAMME

FOLLOWINGCUSUMTRIGGERSTHROUGHIMPLEMENTATIONOF MONDAY EXTERNALPEERREVIEWRECOMMENDATIONS:ASERVICEREVIEW Zia Moinuddin,UnitedKingdom 378 SCHWANNCELLSREGULATEANGIOGENESISANDBLOODVESSEL STRUCTUREINNATIVEANDTRANSPLANTEDPANCREATICISLETS sara M. Ullsten,Sweden 379 APPLICATIONOFHUMANEPINEURALSHEATHCONDUITSUPPORTED BYHUMANMESENCHYMALSTEMCELLSTHERAPYFORREGENERATION OFPERIPHERALNERVEINJURIES Joanna cwykiel,UnitedStates 380 INVESTIGATIONOFTHEMITOCHONDRIALTRANSFERFROMHUMAN MESENCHYMALSTEM/STROMALCELLSTOHUMANPRIMARY HEPATOCYTESTHROUGHTUNNELLINGNANOTUBESASAPOTENTIAL MECHANISMFORCELLSURVIVALANDFUNCTIONENHANCEMENT DURINGHEPATOCYTETRANSPLANTATION Raquel Fernandez Dacosta,UnitedKingdom

18:30–20:30 Young investigators social Evening Cargo Hall (South Wharf)

November 15–19, 2015 | Melbourne, Australia 53 IPITA • IXA • CTS | www.melbourne2015.org NOTES

54 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17 IPITA IXA CTS Joint

07:00–08:00 Orals: Mini-Orals: Experimental islet transplantation Room 110 Chairs: Klearchos K. Papas, United States and Gina Rayat, Canada 400 NEWPORTGREENFORISLET-SPECIFICVIABILITYASSAYBY SEMI-AUTOMATEDMETHOD Hirotake Komatsu,UnitedStates 401 DEVELOPMENTOFAMICROFLUIDIC-BASEDARRAYFOR LARGE-SCALEORDERING,HIGH-THROUGHPUTSCREENAND HIGHRESOLUTIONIMAGINGOFISLETS Yong Wang,UnitedStates 402 GLUTAMINEPLAYSANESSENTIALROLEINTHEFUNCTIONALAND STRUCTURALINTEGRITYOFISOLATEDHUMANISLETS Guo Huang,UnitedKingdom 403 EXAMININGTHEROLEOFFERROPTOSISINISLETISOLATIONANDTRANSPLANTATION Antonio Bruni,Canada 404 PANCREASCOLLAGENDIGESTIONDURINGISOLATIONPROCEDURES FORISLETOFLANGERHANSTRANSPLANTATION Raphael P. H. Meier,Switzerland 405 PROOFOFCONCEPTFORTHECLINICALAPPLICATIONOFANIMAL

COMPONENTFREERECOMBINANTCOLLAGENASEFORISOLATINGPANCREATICISLETS TUESDAY Masafumi Goto,Japan 406 HIGHHUMANISLETYIELDWITHRECOMBINANTCLASSI(RC1)ANDCLASSII(RC2)  COLLAGENASESINCOMBINATIONWITHBP-PROTEASE: EFFICACYOFALOWDOSEOFANANIMAL-FREEENZYMEMIXTUREON HUMANPANCREASDIGESTION Balamurugan N. Appakalai,UnitedStates 407 GLIALCELL-DERIVEDNEUROTROPHICFACTORPROTECTSHUMAN ISLETSFROMAPOPTOSISINDUCEDBYSERUMSTARVATIONAND ENDOPLASMICRETICULUMSTRESSTHROUGHPI3K/AKTSIGNALINGPATHWAY shadab Abadpour,Norway 408 MESENCHYMALSTEMCELLSCULTUREDASSPHEROIDS(MSC-SPH): ATOOLFORIMPROVINGPANCREATICISLETTRANSPLANTATIONOUTCOME talita c. de Oliveira,Brazil 409 HOWABOUTHEPARIN-PEGYLATEDISLETSINALLO-ISLET TRANSPLANTATIONINCYNOMOLGUSMONKEYS Hyojun Park,Korea

November 15–19, 2015 | Melbourne, Australia 55 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - DAY 3 IPITA IXA CTS Joint

07:00–08:00 Orals: cell & tissue Xenotransplantation: tolerance Room 109 Chairs: Mee Kum Kim, Korea and Joerg D. Seebach, Switzerland 410 LACKOFCD47ONDONORHEPATOCYTESINDUCESANTI-DONORT CELLRESPONSES:APOTENTIALBARRIERTOHEPATOCYTEXENOTRANSPLANTATION Mingyou Zhang,UnitedStates 411 CLINICALTRIALOFACELLULARPORCINECORNEALMATRIXIN THETREATMENTOFCORNEALULCER Zhiqiang Pan,People'sRepublicofChina 412 EFFECTANDSAFETYOFANTI-CD40ANTIBODYONTHESURVIVALOF CORNEALXENOTRANSPLANTATION Jaeyoung Kim,Korea 413 EXPERIMENTALSTUDYONGTKO/CD46PIG-TO-RHESUS CORNEALXENOTRANSPLANTATION Xiaojuan Dong,People'sRepublicofChina 414 AFOCUSONTHEROLEOFPLATELETSINLIVERREGENERATION: DOPLATELET-LIVERSINUSOIDALENDOTHELIALCELLINTERACTIONS INITIATETHEREGENERATIVEPROCESS? Raphael P. H. Meier,Switzerland 415 HUMANTOLEROGENICDENDRITICCELLSPARTIALLYINHIBIT XENOGENEICNKANDCD8+TCELLRESPONSESINVITRO Natacha Madelon,Switzerland 416 FOXP3+REGULATORYTCELLSAREESSENTIALFORTHEINDUCTION ANDMAINTENANCEOFTOLERANCETONEONATALPORCINEISLET CELLCLUSTERXENOGRAFTSINDUCEDBYCO-STIMULATORYBLOCKADE TUESDAY Yi Wen Qian,Australia

08:00 –09:00 state-of-the-Art Workshop: Modulating islet inflammation Plenary 1 Chairs: Camillo Ricordi, United States and Greg S. Korbutt, Canada This session is proudly sponsored by the ADS

421 MODULATINGISLETINFLAMMATIONWITHJAKINHIBITORS Helen E. thomas,Australia 422 IL-22-MEDIATEDSUPPRESSIONOFISLETINFLAMMATION Mike A. McGuckin,Australia 423 MECHANISMSOFCYTOKINE-MEDIATEDDAMAGE shane t. Grey,Australia

56 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - DAY 3 IPITA IXA CTS Joint

08:00 –09:00 state-of-the-Art Workshop: integrating Bariatric surgery into Room 110 transplantation Diabetes care Chairs: Rainer W.G. Gruessner, United States and Andrew M. Posselt, United States 425 BARIATRICSURGERYBEFOREORAFTERPANCREASTRANSPLANTATION Andrew M. Posselt,UnitedStates 426 ROLEOFBARIATRICSURGERYINMANAGEMENTOFOBESEDIABETES François Pattou,France 427 METABOLICASSESSMENTAFTERISLETTRANSPLANTATION,PANCREAS  TRANSPLANTATIONORBARIATRICSURGERY Michael R. Rickels,UnitedStates

08:00–09:00 state-of-the-Art Workshop: Genome Engineering for Xenotransplantation Room 109 Chairs: David Ayares, United States and Cesare Galli, Italy 430 SYNTHETICBIOLOGYFORXENOTRANSPLANTATION sean stevens,UnitedStates 431 PRODUCINGHUMANORGANSINPIGS Yifan Dai,UnitedStates TUESDAY

08:00–09:00 state-of-the-Art Workshop: Organ Engineering & Repair Room 111-112 Chairs: Melissa H. Little, Australia and Robert Fisher, United States 435 THEDIRECTEDDIFFERENTIATIONFROMPLURIPOTENTCELLSTOKIDNEYCELLS Melissa H. Little,Australia 436 MESENCHYMALSTEMCELLTHERAPYFORLUNGDISEASE Daniel c. chambers,Australia

09:00–10:30 Plenary: New Horizons Plenary 1 Chairs: Thomas W. Kay, Australia and Jon S. Odorico, United States This session is proudly sponsored by Astellas Australia

440 GENOMEEDITINGWITHCRISPR/CAS9 Alfred Joseph tector,UnitedStates 441 STEMCELLSANDREGENERATIVEMEDICINE:THEFUTUREISNOW Martin Pera,Australia 442 3DPRINTINGSCAFFOLDSCONTAININGLIVINGCELLS Gordon Wallace,Australia Foyer 1 & 2 10:30–11:00 coffee Break

November 15–19, 2015 | Melbourne, Australia 57 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17 IPITA IXA CTS Joint

11:00–12:30 Orals: islet Auto transplantation: state-of-the-Art Plenary 1 Chairs: Horacio L. Rilo, United States and Lorenzo Piemonti, Italy 445 ARANDOMIZEDDOUBLE-BLINDEDPLACEBOCONTROLLEDTRIAL OFDPP-4INHIBITORTHERAPYAFTERTOTALPANCREATECTOMY WITHISLETAUTOTRANSPLANTATION Melena D. Bellin,UnitedStates 446 INTRADUCTALDELIVERYOFALPHA-1-ANTITRYPSININCREASES THEYIELDOFAUTOLOGOUSHUMANISLETSFORTRANSPLANT Joshua J. Wilhelm,UnitedStates 447 PRESERVATIONOFPANCREATICENDOCRINEFUNCTIONAFTERTOTAL PANCREATECTOMYANDISLETAUTOTRANSPLANTATION.ASIXYEARFOLLOWUP Piotr Witkowski,UnitedStates 448 EFFECTSOFPYLORUSPRESERVATIONPROCEDUREONPATIENT OUTCOMEINTOTALPANCREATECTOMYWITHISLETAUTOTRANSPLANTATION Bashoo Naziruddin,UnitedStates 449 FACTORSPREDICTINGOUTCOMESAFTERATOTALPANCREATECTOMY ANDISLETAUTOTRANSPLANTATION:LESSONSLEARNEDFROMOVER500CASES David E.R. sutherland,UnitedStates 450 EFFICACYANDFEASIBILITYOFFULLYAUTOMATEDCLOSEDLOOPINSULIN PUMPTHERAPYAFTERISLETAUTO-TRANSPLANTATION Melena D. Bellin,UnitedStates 451 ISLETLOSSANDENGRAFTMENTMARKERSAFTERTPIAT Melena D. Bellin,UnitedStates 452 ENDOSCOPICAUTOLOGOUSTRANSPLANTATIONOFPANCREATIC TUESDAY ISLETSUNDERNEATHGASTRICMUCOSA–ONE-YEAR-FOLLOW Michał Wszoła,Poland 453 AUTOLOGOUSISLETSANDMESENCHYMALSTEMCELLSCO-TRANSPLANTATION INPATIENTSWITHCHRONICPANCREATITISAFTERTOTALPANCREATECTOMY Hongjun Wang,UnitedStates 454 ASSESSEMENTOFLONG-TERMGRAFTFUNCTIONFOLLOWINGTOTAL PANCREATECTOMYANDAUTOLOGOUSISLETTRANSPLANTATION Wen Yuan chung,UnitedKingdom 455 DOSURGICALCOMPLICATIONSADVERSELYAFFECTTOTAL PANCREATECTOMYWITHISLETAUTOTRANSPLANTATIONOUTCOME? Bashoo Naziruddin,UnitedStates

58 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17 IPITA IXA CTS Joint

11:00–12:30 Orals: Alternative sources of Beta cells: Room 110 Xenoislet, stem cells, tissue Engineering Chairs: Tom Loudovaris, Australia and Julie Kerr-Conte, France 461 MATURATIONOFHUMANPLURIPOTENTSTEMCELL-DERIVED PANCREATICPROGENITORSINTOMONOHORMONALISLET-LIKECELLS AFTERTRANSPLANTATIONTOMICE sara D. sackett,UnitedStates 462 PROTECTIVEPOTENTIALOFMURINETOLEROGENICDENDRITIC CELLSINRAT-TO-MOUSEISLETSXENOTRANSPLANTATIONMODEL Natacha Madelon,Switzerland 463 EFFECTIVECONTROLOFEARLYANTI-XENOGENEICIL-17RESPONSE ISCRITICALFORGRAFTPROTECTIONINXENOGENEICISLETCELLTRANSPLANTATION shusen Wang,People'sRepublicofChina 464 EXTRAHEPATICISLETTRANSPLANTATIONUSINGBIOENGINEERED ADVANCEDMICROFABRICATEDTHIN-FILMMACROPOROUSMICROWELL SCAFFOLDSLEADSTORAPIDRECOVERYOFNORMOGLYCEMIAINDIABETICMICE Aart A. van Apeldoorn,Netherlands 465 BIOPRINTEDISLETSPHEROIDSCONTAININGADIPOSE-DERIVED STROMALVASCULARFRACTIONCELLSUSINGA3DBIOPRINTING TUESDAY TECHNOLOGYIMPROVESISLETINTEGRITYANDFUNCTION Gopalakrishnan Loganathan,UnitedStates 466 ENHANCEDEFFECTOFSHTNFRIANDHHO-1GENEEXPRESSINGHMSC ONPORCINEISLETTRANSPLANTATIONINHUMANIZEDMICE Du Yeon shin,Korea 467 INS-EGFPTRANSGENICPIGLETSPROVIDEANOVELTOOLFORSTUDYING MATURATIONANDVASCULARIZATIONOFNEONATALISLETCELL CLUSTERS(NICCS)INVIVO Elisabeth Kemter,Germany 468 ENGINEERINGNEOISLETSFROMISLET-DERIVEDMESENCHYMALSTEMCELLS Michael c. Lawrence,UnitedStates 469 USINGHUMANPANCREATICISLETSASABIOINKFOR3DBIOPRINTINGFOR BIOENGINEERINGANARTIFICIALPANCREAS-PRELIMINARYREPORT Michał Wszoła,Poland 470 DIRECTCOMPARISONOFADULT,JUVENILE,ANDNEONATALPORCINE ISLETSINVITROREVEALSAGEDEPENDENTDIFFERENCESINVIABILITYANDFUNCTION Kate smith,UnitedStates

November 15–19, 2015 | Melbourne, Australia 59 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17 IPITA IXA CTS Joint

11:00–12:30 Orals: inflammation & coagulation Room 109 Chairs: Charles Esmon, United States and Agnes M. Azimzadeh, United States 475 EFFECTOFPIGGENETICMODIFICATIONONHUMANPLATELET AGGREGATIONINRESPONSETOPIGVASCULARENDOTHELIALCELLS Hayato iwase,UnitedStates 476 ATTENUATIONOFHIGHMOBILITYGROUPBOX1(HMGB1)-MEDIATED PROINFLAMMATORYRESPONSESBYTRANSGENICEXPRESSION OFHUMANTHROMBOMODULINONPIGCELLS Anjan K. Bongoni,Australia 477 EFFECTOFC1ESTERASEINHIBITORTREATMENTOFWILD-TYPEAND MULTI-TRANSGENIC(GALTKO/HCD46)PORCINEAORTICENDOTHELIAL CELLSINANINVITROPIG-TO-HUMANTRANSPLANTATIONMODEL Anjan K. Bongoni,Australia 478 INVITROEXPOSUREOFISOLATEDPORCINEISLETSFROM NEU5GC-KNOCKOUT/GT-KNOCKOUT/HCD46TRANSGENICDONORS TOHUMANBLOOD/PLASMA David Ayares,UnitedStates 479 UNRAVELINGTHEMECHANISTICPATHWAYSOFTHEINSTANTBLOOD MEDIATEDINFLAMMATORYREACTION David Liuwantara,Australia 480 FUNCTIONALEVALUATIONOFIMMORTALIZEDPORCINEENDOTHELIAL CELLSINAWHOLEBLOODCLOTTINGASSAY Riccardo sfriso,Switzerland 481 STUDYOFPROPEREXPRESSIONLEVELOFHUMANTHROMBOMODULIN TUESDAY INPIGENDOTHELIALCELLWITHEFFECTIVEANTICOAGULANTACTIVITY ANDNOBLEEDINGTENDENCY Yuko Miwa,Japan 482 CELLULARSIALYLATIONANDACTIVATIONREGULATEXENOGENEIC NEUTROPHILADHESION Beth M. French,UnitedStates 483 ACTIVATEDPROTEINCMODULATESTHETHROMBOTICPHENOTYPE ANDVASCULARPERMEABILITYOFGALTKO.HCD46PORCINE ENDOTHELIUMEXPRESSINGHUMANENDOTHELIALPROTEINCRECEPTOR Beth M. French,UnitedStates 484 ECTOPICEXPRESSIONOFHUMANCD55ONPORCINECELLS SUPPRESSESMACROPHAGE-MEDIATEDXENOGENEICREJECTION Akira Maeda,Japan 485 HUMANENDOTHELIALCELLACTIVATIONTHROUGHERKBYNON-GALANTIBODY Kenta iwasaki,Japan

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11:00–12:30 Orals: cellular Encapsulation Room 111-112 Chairs: Klearchos K. Papas, United States and Susan A. Safley, United States 490 ENDOTOXIN,PROTEIN,ANDMICROBIOLOGICALIMPURITIESIN ALGINATEHYDROGELSCORRELATEWITHIMMUNE-MEDIATED DESTRUCTIONAFTERISLETTRANSPLANTATION Jonathan R.t. Lakey,UnitedStates 491 ALGINATECOMPOSITIONANDTEMPERATUREINFLUENCE MICROCAPSULEPERMEABILITY Rahul Krishnan,UnitedStates 492 KEYFACTORSINFLUENCINGALGINATEMICROCAPSULESIZE, DIMENSIONSANDLONG-TERMSTABILITY Jonathan R.t. Lakey,UnitedStates 493 HEPARINZATIONOFCELLSURFACESWITHAHEPARIN-BINDING PEPTIDE-CONJUGATEDPEG-LIPIDFORREGULATIONOF THROMBOINFLAMMATIONINTRANSPLANTATIONOFHUMANMSCANDHEPATOCYTE Yuji teramura,Japan 494 ENGINEERINGANINFECTIOUSTREGBIOMIMETICTHROUGH SURFACEBOUNDTGF-β1POLYMERS cherie L. stabler,UnitedStates TUESDAY 495 MICROENCAPSULATEDNON-HUMANPRIMATE(NHP)ISLETALLOGRAFTS ANDPORCINEISLETXENOGRAFTSINSTREPTOZOTOCIN-DIABETICNHPS: ISLETSURVIVAL,FUNCTION,ANDHOSTRESPONSES susan A. safley,UnitedStates 496 ISOTROPICSWELLINGOFALGINATEMICROCAPSULESINAQUEOUS SODIUMCHLORIDEISNEUTRALIZEDATHIGHPH Jonathan R.t. Lakey,UnitedStates 497 BIOSAFE:ANOVELBIOMATERIALFORPANCREATICISLETS ENCAPSULATIONANDTYPE1DIABETESMELLITUSTHERAPY camila Leal-Lopes,Brazil 498 BARIUM-GELLEDALGINATEMICROCAPSULESDONOTEXHIBIT SODIUM-INDUCEDISOTROPICSWELLINGNOTEDWITH CALCIUM-GELLEDMICROCAPSULES Jonathan R.t. Lakey,UnitedStates 499 MATHEMATICALPREDICTIONSOFOXYGENAVAILABILITYINMICRO- ANDMACRO-ENCAPSULATEDHUMANANDPORCINEPANCREATICISLETS Rahul Krishnan,UnitedStates 500 ENGRAFTMENTANDFUNCTIONOFMICROFLUIDICPEG-ENCAPSULATED ISLETSINAHIGHLYVASCULARIZEDALTERNATIVETRANSPLANTSITE Jessica D. Weaver,UnitedStates

12:30–13:30 Lunch Break (on own) - Exhibits & Poster Viewing

November 15–19, 2015 | Melbourne, Australia 61 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17 IPITA IXA CTS Joint

12:30–13:30 Debate: Pancreatic Beta cell Replacement therapy: Room 111-112 What Will We Be Doing in 2025? Moderator: Peter G. Stock, United States and Robert R. Redfield III, United States 505 SOLIDPANCREASTRANSPLANT David E.R. sutherland,UnitedStates 506 SOLIDPANCREASTRANSPLANT Raphael P. H. Meier,Switzerland 507 STEMCELLDERIVEDBETACELLS Jon s. Odorico,UnitedStates 508 STEMCELLDERIVEDBETACELLS christian s. schuetz,UnitedStates 509 XENO-ISLETTRANSPLANT Bernhard J. Hering,UnitedStates 510 XENO-ISLETTRANSPLANT Nathan W. Zammit,Australia 511 AUTO/ALLO-ISLETTRANSPLANT Barbara Ludwig,Germany 512 AUTO/ALLO-ISLETTRANSPLANT Hanne scholz,Norway

13:30–15:00 Plenary: special Lectures Plenary 1 Chairs: Jon S. Odorico, United States, Richard N. Pierson III, United States and Maria Koulmanda, United States TUESDAY 515 RICHARDC.LILLEHEILECTURE:GENETHERAPYFORDIABETES Hans W. sollinger,UnitedStates 516 KEITHREEMTSMALECTURE:XENOTRANSPLANTATION-THEPASTANDTHEFUTURE Mark A. Hardy,UnitedStates 517 CAMILLORICORDILECTURE:TRANSLATIONALCHALLENGESAND OPPORTUNITIESINCELLULARTHERAPIESANDREGENERATIVEMEDICINE camillo Ricordi,UnitedStates

15:00–15:30 coffee Break Foyer 1 & 2

62 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17 IPITA IXA CTS Joint

15:30–17:00 Orals: Modifying islet immunity - Adaptive, innate, and Xenoimmunity Plenary 1 Chairs: Shane T. Grey, Australia and Claire F. Jessup, Australia 520 MESENCHYMALSTEMCELLSCO-TRANSPLANTEDWITHNEONATAL PORCINEISLETSIMPROVEREVASCULARIZATION,MORERAPID CORRECTIONOFDIABETESANDLONG-TERMGRAFTFUNCTIONIN DIABETICMICE Julie A. Hayward,Canada 521 LIVINGDONORISLETALLOGRAFTSINHAPLOTYPEIDENTICALMACAQUES: EFFECTOFCHIMERISMANDANTI-DONORANTIBODIESONISLET ALLOGRAFTSURVIVAL James V. Harmon Jr.,UnitedStates 522 HUMANMESENCHYMALSTROMALCELLSIMPROVESURVIVALAND FUNCTIONOFPANCREATICIISLETSBYCELL-TO-CELLCONTACT THROUGHN-CADHERIN Elisa Montanari,Switzerland 523 THEINTRA-ADRENALISLETTRANSPLANTATIONMODEL.CONVERGENCE OFPANCREATICISLETSWITHENDOCRINE“HELPERCELLS” Undine schubert,Germany 524 GENETICPOLYMORPHISMSINDONORTISSUEDETERMINE TRANSPLANTOUTCOMES TUESDAY Nathan W. Zammit,Australia 525 APROTEASOMEINHIBITOR,BORTEZOMIBPREVENTSPANCREATIC ISLETGRAFTLOSSAFTERTRANSPLANTATION Hitoshi Ono,Japan 526 ATTENUATIONOFIMMUNOSUPPRESSIONRELATEDNEGATIVEEFFECTS ONISLETGRAFTSBYGROWTHHORMONERELEASINGHORMONE(GHRH)AGONIST Barbara Ludwig,Germany 527 TARGETINGISLET-DERIVEDIFN-GAMMA-INDUCIBLEPROTEIN10(IP-10/CXCL10) TOPREVENTEARLYINNATEIMMUNEDESTRUCTIONOFISLETGRAFTS Gumpei Yoshimatsu,UnitedStates 528 COMPREHENSIVEGENEANALYSISONEX-VIVOMITOMYCIN-CTREATMENT ASAPOTENTIALPROTOCOLFORINDUCINGUNRESPONSIVENESSTO ISLETENGRAFTMENT:HARMONIZEDDOWNREGULATIONOF MULTIPLECHEMOTAXISFACTORS Naoya sato,Japan 529 LOCALIZEDRELEASEOFLOW-DOSEDEXAMETHASONEFROMMACROPOROUS  SCAFFOLDSIMPROVESISLETENGRAFTMENTINMURINEMODEL Kaiyuan Jiang,UnitedStates 530 PANCREATICISLETCULTUREINDUCESTOLEROGENICEFFECTSASWELL ASSTIMULATESIMMUNECELLTRAFFICKINGBYREGULATING INFLAMMATORYCYTOKINES takayuki Anazawa,Japan

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15:30–16:30 Orals: Zeroing in on the Perfect Encapsulation and immunoisolation Device Room 110 Chairs: Cherie L. Stabler, United States and David W. Scharp, United States 535 ENHANCEDOXYGENSUPPLYTOISLETSENCAPSULATEDATHIGH DENSITYLEADSTOLONG-TERMNORMOGLYCENIAINDIABETIC RATSANDFACILITATESDEVELOPMENTOFSMALLERDEVICES clark K. colton,UnitedStates 536 ENGINEERINGANINVITROPLATFORMFORCHARACTERIZATIONOF ANTIGENRECOGNITIONFORENCAPSULATEDISLETS Anthony W. Frei,UnitedStates 537 PRECLINICALVALIDATIONOFTHEMAILPAN®,ABIOARTIFICIAL PANCREASTOTREATTYPE1DIABETES Richard Bouaoun,France 538 INVIVOANDINVITROCHARACTERIZATIONOF1.5MMBA2+-ALGINATE MACRO-ENCAPSULATEDCYNOMOLGUSMONKEYISLETS Matthew A. Bochenek,UnitedStates 539 THEDEVELOPMENTANDUTILITYOFAPREVASCULARIZEDSUBCUTANEOUS ‘DEVICE-LESS’SITEFORBETACELLREPLACEMENTTHERAPY Andrew R. Pepper,Canada 541 EFFECTSOFACTIVATEDMESENCHYMALSTROMALCELLSONISLETSECRETORY FUNCTIONANDCELLULAROVERGROWTHONMICROENCAPSULATEDISLETS Ahmed A. Arzouni,UnitedKingdom 542 NANOBIOTECHNOLOGYTODELIVERANTI-INFLAMMATORYAGENTSTO ISLETTRANSPLANTATIONSITES Amazon L.F. Austin,UnitedKingdom TUESDAY 543 DEVELOPMENTOFNOVELCELLSHEETTECHNOLOGY;HYBRIDISLET CELLSHEETSLAMINATEDWITHMESENCHYMALSTEMCELLS Hirofumi shimizu,Japan 544 CYTOKINEPROFILESOFJUVENILEPORCINEISLETSDURINGPROLONGED  INVITROCULTUREANDAFTERALGINATEMICROENCAPSULATION Jonathan R.t. Lakey,UnitedStates 545 AUTOMATIONOFMICROCAPSULEEVALUATIONANDCHARACTERIZATION FORUSEINISLETTRANSPLANTATION Rahul Krishnan,UnitedStates

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15:30–16:30 Orals: Non-Gal Antibodies Room 109 Chairs: Guerard W. Byrne, United Kingdom and Uri Galili, United States 550 GGTA1/CMAH/β4GALNT2KNOCKOUTPORCINECELLSHAVE REDUCEDHUMANANTIBODYBINDINGANDACHIEVEDNEARBACKGROUND THRESHOLDSFORMOSTTRANSPLANTPATIENTSANDREMAINING ANTIBODYBINDINGISPARTIALLYATTRIBUTABLETOSWINELEUKOCYTEANTIGEN Gregory R. Martens,UnitedStates 551 ANEWXENOANTIGEN:HUMANNATURALIGMANTIBODIESBIND TONON-MUSCULARMYOSINHEAVYCHAINTYPEIIONPORCINEENDOTHELIALCELLS Robert Rieben,Switzerland 552 N-GLYCOLYLNEURAMINICACID(NEU5GC)KNOCK-OUTINGALTKO.HCD46 PIGLUNGSIMPROVESPULMONARYFUNCTIONINAXENOGENEIC PIG-TO-HUMANLUNGPERFUSIONMODEL Lars Burdorf,UnitedStates 553 INVESTIGATIONOFTHEPOTENTIALCLINICALSIGNIFICANCEOFTHE EXPRESSIONOFNEUGCONPIGAORTASANDCORNEAS Whayoung Lee,UnitedStates 554 THEPOTENTIALSIGNIFICANCEOFNEUGCINTHESTRUCTURALVALVE DETERIORATIONOFBIOPROSTHETICHEARTVALVES Whayoung Lee,UnitedStates TUESDAY 555 INCREASEDLATEGRAFTLOSSINKIDNEYRECIPIENTSWITHSERUM SICKNESSDISEASEFOLLOWINGANTI-THYMOCYTEGLOBULININDUCTION: RELATIONWITHANANTI-NEU5GCRESPONSE Apolline salama,France 556 INCREASEDIGMANDIGGANTI-NEU5GCANTIBODIESININFECTIOUS MONONUCLEOSIS(IMN):LINKWITHMULTIPLESCLEROSIS(MS)? Ludmilla L. Le Berre,France

15:30–17:00 Orals: immunology Room 111-112 Chair: Ewa C. Ellis, Sweden 560 CTLA-4PLAYSANIMPORTANTROLEINTREG-MEDIATEDSUPPRESSION OFTHEXENOIMMUNERESPONSE Xiaoqian Ma,People'sRepublicofChina 561 CONJUGATIONOFHUMANRECOMBINANTCD39TOPRIMARYHUMAN HEPATOCYTESPROTECTSAGAINSTTHROMBOINFLAMMATION sana Asif,Sweden 562 ISLETRESIDENTMACROPHAGESAREIMMUNOREGULATORYAND PROLONGISLETTRANSPLANTSURVIVAL Periklis Panos Kyriazis,UnitedStates

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563 DENDRITICCELLTARGETEDTHERAPYUTILISINGPOROUS SILICONNANOPARTICLES sebastian O. stead,Australia 564 THEHUMANMONOCLONALANTIBODY3C12CTARGETINGACTIVATED DENDRITICCELLSISAPOTENTIALNEWIMMUNOSUPPRESSIVEAGENT Pablo A. silveira,Australia 565 OVERCOMINGIMMUNESENESCENCETOESTABLISHTRANSPLANTATIONTOLERANCE tracy s. P. Heng,Australia 566 MODIFICATIONOFTHE“ONESTUDY”PANELSFORWHOLEBLOOD IMMUNOPHENOTYPICMONITORINGFORTRANSPLANTCLINICAL TRIALSANDISLETTRANSPLANTPATIENTSATWESTMEAD Min Hu,Australia 567 SAFETYANDEFFICACYOFTHIRD-PARTYUMBILICALCORD BLOOD-DERIVEDREGULATORYTCELLS Xiaoqian Ma,People'sRepublicofChina 568 PRECLINICALSCREENINGFORACUTETOXICITYOFTHERAPEUTICMONOCLONAL ANTIBODIESINAHUMANIZEDMOUSEMODEL Jamie L. Brady,Australia 569 THEDISTINCTAPOPTOTICIDENTITYOFDENDRITICCELLSOFFERS NOVELTARGETSFORIMMUNOSUPRESSION Emma M. carrington,Australia

16:30–17:00 Lecture: iXA Honorary Member Lecture Room 109 Chair: Takaaki Kobayashi, Japan 570 INTRODUCTION TUESDAY David K.c. cooper,UnitedStates 571 iXA HONORARY MEMBER LEctURE Uri Galili,UnitedStates

17:00–17:30 iXA BUsiNEss MEEtiNG (association info on page 8) Room 109

17:30–18:30 Poster: Joint Poster session Foyer 1 & 2 CELL TRANSPLANT TRACK 575 THETHERAPEUTICPOTENTIALOFHUMANLIVER-DERIVEDSTEMCELLS TRANSPLANTATIONINACIRRHOTICLIVERRATMODEL sanghoon Lee,Korea 576 COMBINATIONOFRITUXIMABANDBEAMASTHEPRECONDITION REGIMENOFAUTO-HSCTACHIEVEDPERSISTINGCOMPLETEREMISSION INANANGIOIMMUNOBLASTICT-CELLLYMPHOMAPATIENT Xin Wang,People'sRepublicofChina 577 ANOVELMETHODFORMURINEINTRAHEPATICISLETTRANSPLANTATION VIACECALVEIN Nari Byun,Korea

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578 LOWMOLECULARWEIGHTHEPARINPREVENTSMOUSECOLON CANCERLIVERMETASTASESBYINHIBITINGHEPARANASEANDIFNY INDUCIBLECHEMOKINES souad s.Djaafar,Switzerland 579 BRIDGINGTHERAPYOFDONOR-RECIPIENTCHIMERICCELLAGAINST HEMATOPOIETICACUTERADIATIONSYNDROME Joanna cwykiel,UnitedStates 580 COMPOSITEMEMBRANEPROTECTINGIMPLANTEDISLETSFROM ALLOGENICANDXENOGENEICHOSTIMMUNESYSTEM Uriel Barkai,Israel 581 INCUBATIONATPHYSIOLOGICALTEMPERATURESINDUCEIRREVERSIBLE ISOTROPICSHRINKAGEINALGINATEMICROCAPSULES Jonathan R.t. Lakey,UnitedStates 582 EVALUATIONOFALGINATEBIOCOMPATIBILITYBYANALYZINGMACROPHAGE ADHESIONDURINGINVITROCO-CULTURE Jonathan R.t. Lakey,UnitedStates 583 NOVELMULTICOMPARTMENTALBILEACID-BASEDMICROCAPSULESFOR PANCREATICβ-CELLTRANSPLANTATION Armin Mooranian,Australia

584 ORGANPROCUREMENTTHROUGHHOSPITALBASEDAUTHORIZATIONCOMMITTEE: TUESDAY ASTUDYOFINDIANSCENARIO Hem chandra,India 585 ORGAN-DERIVEDMICRO-SCAFFOLDSFORTHEFORMATIONOF MICRO-PANCREATA-FURTHERIMPROVEMENTSONINSULINSECRETION ANDSTIMULATIONINDEX Lena sapozhnikov,Israel 586 NON-INVASIVEASSESSMENTOFTISSUE-ENGINEEREDGRAFTVIABILITY WITHOXYGEN-17MAGNETICRESONANCESPECTROSCOPY Bradley P. Weegman,UnitedStates 587 KRüPPEL-LIKEFACTOR4OVEREXPRESSIONINITIATESAMESENCHYMAL -TO-EPITHELIALTRANSITIONANDREDIFFERENTIATIONOFHUMANPANCREATIC CELLSFOLLOWINGEXPANSIONINLONGTERMADHERENTCULTURE Hilary M. Docherty,UnitedKingdom 588 OVEREXPRESSIONOFEXOGENOUSPAX4COMBINEDWITHSUPPRESSIONOF  ENDOGENOUSARXENHANCESBETA-CELLLINEAGESPECIFICATIONAND MATURATIONDURINGTHEEXVIVOTRANSDIFFERENTIATIONOFHUMAN EXOCRINEPANCREATICTISSUE Maria Joao Lima,UnitedKingdom 589 EFFICIENTREPROGRAMMINGOFCENTENARIAN’SSOMATICCELLS, PERSONALIZEDGERIATRICMEDICINE Massoud Vosough,Sweden

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PANCREAS AND ISLET TRACK 590 3DIMAGINGFORISLETGRAFTSINTHETRANSPARENTLIVERBY WHOLE-ORGANCLEARINGMETHOD Masayuki shimoda,Japan 591 DEVELOPMENTOFARELIABLEREAL-TIMEASSAYFOREVALUATING HUMANISLETFUNCTIONANDVIABILITYPRIORTOTRANSPLANT Yong Wang,UnitedStates 592 AQUALITATIVEEVALUATIONOFPATIENTEXPERIENCESFOLLOWING ISLETTRANSPLANTATION Rob J.R. crookston,UnitedKingdom 593 SUCCESSFUL12-YEAROUTCOMESOFANATIONALISLETTRANSPLANT PROGRAMCENTRE Wayne J. Hawthorne,Australia 594 ACASEREPORTOFATYPE1DIABETESPATIENTMAINTAININGC-PEPTIDE SECRETIONFORTENYEARSAFTERISLETTRANSPLANTATIONUSINGDONATION AFTERCARDIOCIRCULATORYDEATH(DCD)DONORS Yasuhiro iwanaga,Japan 595 EVALUATIONOFPANCREATICDONORSFORISLETISOLATION Frantisek saudek,CzechRepublic 596 ISLETANDPANCREASTRANSPLANTATIONOUTCOMESINASINGLE TRANSPLANTCENTRE Frantisek saudek,CzechRepublic 597 MODIFIEDISLETISOLATIONTECHNIQUESCANISOLATEHIGHISLETYIELD EVENFROMALCOHOLICPANCREATITISPANCREASESINTENDEDFOR CLINICALISLETAUTO-TRANSPLANTION TUESDAY Balamurugan N. Appakalai,UnitedStates 598 PANCREATECTOMYANDISLETAUTOTRANSPLANTATIONASAFINAL TREATMENTOFPAINFULCHRONICPANCREATITISINPATIENTSWITHDIABETES Andrzej Berman,Poland 599 DEFICIENCYOFMANNOSE-BINDINGLECTIN–DEPENDENTLECTINPATHWAYIN THEPANCREATICISLETAUTO-TRANSPLANTATION Wen Yuan chung,UnitedKingdom 600 AUTOLOGOUSISLETCELLTRANSPLANTATIONFOLLOWINGDUODENUM SPARINGTOTALPANCREATECTOMYINSITUSINVERSUSTOTALISTO TREATCHRONICPANCREATITIS Jose Oberholzer,UnitedStates 601 ISLETAUTOTRANSPLANTATIONAFTERDISTALPANCREATECTOMYFORCYSTIC NOEPLASMSLOCATEDINTHEMIDDLEPARTOFTHEPANCREAS Michihiro Maruyama,Japan

68 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17 IPITA IXA CTS Joint

602 TOTALPANCREATECTOMYANDISLETAUTO-TRANSPLANTATIONFOR ANAMPULLARYCARCINOMA:ACASEREPORT Piotr Witkowski,UnitedStates 603 CORRELATIONOFTHEHISTOPATHOLOGICSTAGINGINCHRONIC PANCREATITISWITHISLETISOLATIONANDAUTOTRANSPLANTATIONOUTCOME Piotr Witkowski,UnitedStates 604 SUCCESSFULAUTOLOGOUSISLETTRANSPLANTATIONPOST-FREY'S PROCEDUREUSINGASIDE-VENTED'THERAPEUTICINFUSIONNEEDLE FORIMPROVEDENZYMEDELIVERY William E. scott iii,UnitedKingdom 605 EXPANDINGTHEINDICATIONSFORPAEDIATRICANDADULTAUTOLOGOUS ISLETTRANSPLANTATION William E. scott iii,UnitedKingdom 606 GRAFTFUNCTIONOF“NATURALLYPURIFIED”AUTOLOGOUSISLETSISOLATED FROMCHRONICPANCREATITISPANCREASESFOLLOWINGTOTALPANCREATECTOMY Joshua J. Wilhelm,UnitedStates 607 TRANSCRIPTOMEANALYSISOFVASCULARISCHEMIA-REPERFUSION INJURYINRHESUSMONKEYS Younan chen,People'sRepublicofChina

608 PANCREASTRANSPLANTATIONPREVENTSTHEPROGRESSIONOF TUESDAY MORPHOLOGICAL,MORPHOMETRICANDULTRASTRUCTURALCHANGES OFTESTESOFALLOXAN-INDUCEDDIABETICRATS césar tadeu spadella,Brazil 609 DRIVE:DIABETESREVERSINGIMPLANTSWITHENHANCEDVIABILITY ANDLONG-TERMEFFICACY Garry P. Duffy,Ireland 610 THEOPTIMALTIMINGCANIMPROVEENGRAFTMENTOFPANCREATICISLETS TRANSPLANTEDINTOTHESUBCUTANEOUSCAVITY Lucie Kosinová,CzechRepublic 611 BIOACTIVECOVALENTLAYER-BY-LAYERPLATFORMSFORCELLULARENCAPSULATION cherie L. stabler,UnitedStates 612 OXYGENATIONOFCELLENCAPSULATINGDEVICESALLOWSFORGREATER SURVIVALOFCELLSINVITRO Allison E. irvin,Australia 613 EVALUATINGVARIOUSALGINATEHYDROGELCOMPOSITIONSANDTRANSPLANT SITESFORENCAPSULATEDISLETTRANSPLANTATION Rahul Krishnan,UnitedStates 614 PREPARATIONOFIMMUNETOLERANCESITEBYCYCLICPEPTIDEFOR ISLETSTRANSPLANTATIONATSUBCUTANEOUSSITES Rei Kuwabara,Japan

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615 ENGINEERINGANOPTIMALBIOARTIFICIALPANCREASFORISLET TRANSPLANTATIONUSINGOXYGENGENERATINGSCAFFOLD Eun Mi Lee,Korea 616 NEWSTRATEGYOFISLETVIABILITYIMPROVEMENTINBIOARTIFICIAL PANCREASUSINGCOMPOSITESISLETS/MSC-A Elisa Maillard Pedracini,France 617 ANTI-FIBROTICEFFECTSOFRAPAMYCIN-CONTAININGPOLYETHYLENE GLYCOL-COATEDALGINATEMICROCAPSULESINISLETXENOTRANSPLANTATION Hae Kyung Yang,Korea 618 THEEFFECTOFDSS-INDUCEDCOLITISONMURINEINTRAHEPATIC ISLETALLOGRAFTMODEL seong-Jun Kang,Korea 619 COMPARISONOFISLETARCHITECTURE,BETACELLCONTENT,ANDXENOANTIGENICITY Jonathan R.t. Lakey,UnitedStates 620 HUMANISLETSEXPRESSINGPROGRAMMEDDEATHLIGAND2REGULATE IMMUNERESPONSESBYSUPPRESSINGT-CELLS sebastian O. stead,Australia 621 CO-AGGREGATIONOFCURCUMINLOADEDPOLY(LACTIC-CO-GLYCOLICACID)  MICROSPHERESWITHPANCREATICISLETCELLSINTOHETEROSPHEROIDS; APOTENTIALSTRATEGYTODELIVERDRUGSANDBIOLOGICALAGENTSTO THEISLETSOFLANGERHANS Jee-Heon Jeong,Korea 622 DEVELOPMENTOFNOVELPEGYLATEDBILIRUBIN-BASEDNANOVESICLE(BRNV) FORCYTOPROTECTIONOFXENOTRANSPLANTEDPANCREATICISLETS Min Jun Kim,Korea TUESDAY 623 DECELLULARIZEDPANCREASBIOSCAFFOLDGENERATIONANDRECONSTITUTION AIMINGATTYPE1DIABETESTHERAPEUTICS Marluce c. Mantovani,Brazil 624 DEVELOPMENTOFHUMANPANCREATICEXTRACELLULARMATRIXSCAFFOLD ANDHYDROGELPLATFORMSFORPROMOTINGENDOCRINESPECIFICATIONAND FUNCTIONFROMHUMANPLURIPOTENTSTEMCELLS Daniel M. tremmel,UnitedStates 625 IDENTIFICATIONOFANOVELDIFFERENTIALLY-EXPRESSEDMICRO-RNASIGNATURE  PROFILEASAPOTENTIALBIOMARKERFORRISKPREDICTIONANDDIAGNOSISOF  AUTOIMMUNETYPE1DIABETES Kenneth L. Brayman,UnitedStates 626 DEVELOPMENTOFANOVELPERFUSIONCHAMBERFORSTUDYINGISLETECM DIGESTIONINREAL-TIME Di shen,UnitedKingdom 627 IMPAIREDGENEEXPRESSIONINPANCREATICISLETSEARLYAFTERISOLATION CANAFFECTTHERESULTSOFGENEEXPRESSIONSTUDIES Lucie Kosinová,CzechRepublic

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628 PROLONGEDINVITROCULTUREATHYPOXICCONDITIONSDOESNOT INDUCEAPOPTOSISINJUVENILEPORCINEISLETS Rahul Krishnan,UnitedStates 629 DONORANDISOLATION-RELATEDVARIABLESINFLUENCEYOUNGPIGLET ISLETISOLATIONOUTCOMES Jonathan R.t. Lakey,UnitedStates 630 COMPARISONOFPANCREATAANDISLETPREPARATIONSFROMAVARIETY OFHUMANDONORS tom Loudovaris,Australia 631 IMPROVEMENTOFPANCREASQUALITYANDISLETISOLATIONYIELDBY ADENOSINEANDOXYGENINPERFUSIONSOLUTION Elisa Maillard Pedracini,France 632 STANDARDIZEDCOLDSHIPMENTOFHUMANISLETSFORRESEARCH Barbara J. Olack,UnitedStates 633 THEINFLUENCEOFAGEONISLETSIZEDISTRIBUTIONINMALEANDFEMALERATS Anja steffen,Germany 634 PROFILINGOFINFLAMMATORYREACTIONSCAUSEDBYINTRAPERITONEAL TRANSPLANTATIONOFALGINATE-PLO-ALGINATEMICROENCAPSULATED PORCINEISLETSINMICE

takeshi itoh,Japan TUESDAY 635 ACTIVATIONOFPANCREATICPROGENITORSDURINGISOLATIONOFPORCINE NEONATALPANCREATICCELLCLUSTERS Jyuhn-Huarng Juang,Taiwan 636 DEVELOPMENTOFPORCINECELLLINESTHATLACKPORCINEINSULIN EXPRESSIONANDHARBORAHUMANINSULINEXPRESSIONVECTORTOBE USEDFORXENO-ISLETCELLTRANSPLANTATION Kwangwook Park,Korea 637 COSTANDSCALABILITYANALYSISOFPORCINEISLETISOLATION: COMPARISONOFYOUNGPIGLETTOADULTPIGS Jonathan R.t. Lakey,UnitedStates 638 ANALYSISOFTHECELLULARCOMPOSITIONOFJUVENILEPORCINE ISLETSDURINGPROLONGEDINVITROCULTURE Jonathan R.t. Lakey,UnitedStates 639 MOLECULARIMMUNOLOGYPROFILESOFMONKEYSXENOGRAFTEDWITHTHE ISLETSANDHEARTSOFα-1,3-GALACTOSYLTRANSFERASEKNOCK-OUT(GALTKO)PIGS sun A. Ock,Korea 640 HIGHQUALITYPORCINEISLETSCANBEISOLATEDFROMMIDDLE-AGEDMINIATUREPIGS Masayuki shimoda,Japan

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XENOTRANSPLANTATION TRACK 641 REGULATIONOFTHEINFLAMMATORYRESPONSEBYHUMANTHROMBOMODULIN  TRANSGENICPIGSINXENOTRANSPLANTATION Hayato iwase,UnitedStates 642 RAT-TO-CHINESETREESHREWHEARTTRANSPLANTATION: NOVELSMALLANIMALMODELTOSTUDYNON-GAL-MEDIATED DISCORDANTXENOGRAFTHUMORALREJECTION WeiLi chen,People'sRepublicofChina 643 DIFFERENCESINREACTIVITYOFHUMANSERABETWEENXENOGENEIC NEU5GCANDα1,3GALANTIGEN sunghoon Hurh,Korea 644 THEADDITIONALANALYSISFORN-LINKEDSUGAROFADULTPIGISLETS(API) MAYSUPPLEMENTTHEPREVIOUSDATA shuji Miyagawa,Japan 645 ASSESSMENTOFPERVTRANSMISSIONACROSSANALGINATEBARRIER FORTHEENCAPSULATIONOFPORCINEISLETS claire L. crossan,UnitedKingdom 646 XENOANTIGENSTIMULATEDANDEXPANDEDBABOONREGULATORYTCELLS ARECAPABLEOFPROTECTINGAGAINSTPORCINEISLETXENOGRAFT REJECTIONINABABOONISEDMOUSEMODEL shounan Yi,Australia 647 HEPATICSTEATOSISINIMMUNOSUPPRESSEDDIABETICNON-HUMANPRIMATE TRANSPLANTEDWITHPIGISLETS Byoung-Hoon Min,Korea 648 THECONSEQUENCEOFLONG-TERMSURVIVALOFPORCINEISLETGRAFTIN  TUESDAY IMMUNOSUPPRESSEDNONHUMANPRIMATES:GIVINGANOPPORTUNITYTO ADDRESSTHREEIMPORTANTISSUESINISLETXENOTRANSPLANTATION Jun-seop shin,Korea 649 ANTI-THYMOCYTEGLOBULIN(ATG)-INDUCEDT-CELLDEPLETIONINCYNOMOLGUS  MONKEY-FORTHEATGUSEINNON-HUMANPRIMATEORGANTRANSPLANTMODEL Du Yeon shin,Korea 650 HUMANREGULATORYMACROPHAGESINDUCEDINVITROAREHIGHLY SUPPRESSIVEINXENO-BASEDIMMUNERESPONSE Yixiong tan,Australia

72 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 17  IPITA IXA CTS Joint 651 ROLEOFNATURALANTI-αGALANTIBODYREPERTOIREANDANTIBODY-MEDIATED DAMAGERISKINTHECLINICALUSEOFANIMAL-DERIVEDTISSUES Emanuele cozzi,Italy 653 QUANTIFICATIONOFCYTOMEGALOVIRUSDNAUSINGAREAL-TIMEPOLYMERASE CHAINREACTIONASSAYINCYNOMOLGUSMONKEY(MACACAFASCICULARIS) Hyojun Park,Korea 654 COMPARATIVESTUDYONTHEMETHODSOFDETERMININGABOHISTO-BLOOD GROUPANTIGENSINCYNOMOLGUSMONKEYS(MACACAFASCICULARIS) Hyojun Park,Korea 655 THEEFFECTOFANTI-CD20ANTIBODYTREATMENTINCYNOMOLGUSMONKEYS Hyojun Park,Korea 656 PIGPANCREASPRESERVATIONANDTHEINFLUENCEONISLETISOLATIONOUTCOME Anja steffen,Germany 657 THEINNATEIMMUNOLOGICALRESPONSE,INCLUDINGTHECOMPLEMENTSYSTEM, OFPIGSAGAINSTHUMANSTRONGLYEXIST shuji Miyagawa,Japan 658 PANCREASTRANSPLANTATIONFROMLIVINGDONOR: ASINGLECENTEREXPERIENCEOF20CASES Ji Yoon choi,Korea TUESDAY 19:00–22:30 congress Dinner (details on page 27) Melbourne Cricket Ground

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74 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 18 IPITA IXA CTS Joint

07:00–08:00 Women in transplantation: Networking Breakfast Room 109 Megan Sykes and Lori West This session is proudly sponsored by Astellas

Breakfast will be served to networking event attendees on a first-come, first-served basis

08:00–09:00 state-of-the-Art Workshop: Allo and Autoimmunity Plenary 1 Chairs: Helen E. Thomas, Australia and Robyn Sutherland, Australia 700 NPODANDBETACELLAUTOIMMUNITY Alberto Pugliese,UnitedStates 701 BREGSANDTREGSINISLETTRANSPLANTSURVIVAL Jim Kim,UnitedStates 702 TREGSANDBETACELLPRESERVATIONINDIABETESANDISLETTRANSPLANTATION Piotr trzonkowski,Poland 703 TREGINFUSIONSFORMODULATIONOFISLETTRANSPLANTTOLERANCE Qizhi tang,UnitedStates

08:00–09:00 state-of-the-Art Workshop: Progress in tissue & cell Xenotransplantation Room 110 Chairs: Emanuele Cozzi, Italy and Leo H. Buehler, Switzerland 705 CORNEAS Mee Kum Kim,Korea

706 HEARTVALVES WEDNESDAY Whayoung Lee,UnitedStates 707 ISLETS(I):RESULTSFROMTHENHPMODEL chung-Gyu Park,Korea 708 ISLETS(II):IMPROVINGISLETFUNCTION Pierre R. Gianello,Belgium

08:00–09:00 state-of-the-Art Workshop: solid Organ Xenotransplantation: surgical tips Room 109 Chairs: Alfred Joseph Tector, United States and Kazuhiko Yamada, United States 710 KIDNEY Kazuhiko Yamada,UnitedStates 711 HEART(ORTHOTOPIC) christopher G.A. McGregor,UnitedKingdom 712 LIVER Burcin Ekser,UnitedStates 713 LUNG Richard N. Pierson iii,UnitedStates

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08:00–09:00 state-of-the-Art Workshop: What's New in cell therapy Room 111-112 Chairs: Richard L. Boyd, Australia and Ian F.C. McKenzie, Australia 715 BIOMARKERSOFDONORCELLFUNCTIONINCLINICALHEPATOCYTETRANSPLANTATION Ewa c. Ellis,Sweden 716 THYMUSSTEMCELLSFORRESTORINGIMMUNITY Ann P. chidgey,Australia 717 CELLTRANSPLANTATION/THERAPYFORKIDNEYDISEASE torbjorn Lundgren,Sweden

09:00–10:30 Plenary: controlling inflammation & coagulation Plenary 1 Chairs: Peter Cowan, Australia and Eli C. Lewis, Israel This session is proudly sponsored by TSANZ TSANZ The Transplantation Society o Australia and New Zealand

720 NATURALANTICOAGULANT/ANTI-INFLAMMATORYMECHANISMS charles Esmon,UnitedStates 721 THEROLEOFINFLAMMATIONINCELLTRANSPLANT Maria Koulmanda,UnitedStates 722 NEWREAGENTSTOREGULATECOMPLEMENTACTIVATION John Lambris,UnitedStates

10:30–11:00 coffee Break Foyer 1 & 2

11:00–12:30 Orals: islet immunity and tolerance Plenary 1 Chairs: Qizhi Tang, United States and Patrick T. Coates, Australia 725 ANOVELTHERAPYUSINGLOCALIZEDDELIVERYOFBIOPATTERNED CTLA4/FCFUSIONPROTEINSTOPROMOTEISLETALLOGRAFTSURVIVAL ANDTOLERANCE Wensheng Zhang,UnitedStates 726 DECIPHERINGTHEMECHANISMOFACTIONOFPOLYCLONALIGM IMMUNOTHERAPYINTHEPREVENTIONOFTYPE1DIABETESONSET WEDNESDAY ANDPROGRESSIONASWELLASINTHEPROMOTIONOFLONGITUDINAL SYNGENEICANDALLOGENEICISLETGRAFTSURVIVALFOLLOWINGTRANSPLANTATION Kenneth L. Brayman,UnitedStates 727 CHARACTERISATIONOFTHEIMMUNOMODULATORYACTIONOFNOVEL ANTI-CXCR3MONOCLONALANTIBODYEXPLOITINGACONSERVEDHUMAN ANDMURINEEPITOPE suzanna M. Pilgrim,Australia 728 REPOPULATINGTCELLSANDALPHA1-ANTITRYPSINTHERAPYSYNERGIZETOREMOVE THEIMMUNOLOGICALBARRIERTOSUCCESSFULISLETXENOTRANSPLANTATION Boris M. Baranovski,Israel

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729 ISLETTRANSPLANTATIONINTHEIMMUNEPRIVILEGEDEYEANTERIORCHAMBER ANDIMMUNETOLERANCEINDUCTIONTOTREATT1D Midhat H. Abdulreda,UnitedStates 730 SUPPRESSIONOFPANCREASAUTOIMMUNITYUSINGENDOGENOUSLY EXPANDEDREGULATORYTCELLS Ehren N. Rudolph,UnitedStates 731 TANDBCELLSIGNATURESASSOCIATEDWITHSURVIVALANDREJECTIONOF INTRAPORTALPORCINEISLETXENOGRAFTSINIMMUNOSUPPRESSED CYNOMOLGUSMACAQUES Amar singh,UnitedStates 732 CIRCULATINGCD8+EFFECTORMEMORYTCELLS–ACANDIDATEBIOMARKER FORIMMINENTREJECTIONOFPORCINEISLETXENOGRAFTSINNONHUMANPRIMATES Amar singh,UnitedStates 733 PANCREASTRANSPLANTATIONALONEAFTERFAILUREOFISLET TRANSPLANTATIONALONEANDVICEVERSA:IMMUNIZATIONASSOCIATEDRISKS Paola Maffi,Italy 735 ALTEREDINTESTINALMICROBIALCOMPOSITIONASAPOTENTIALBIOMARKEROF  DYSREGULATEDIMMUNITYINTYPE1DIABETESMELLITUS Kenneth L. Brayman,UnitedStates

11:00–12:30 Orals: Pancreas and islet transplantation: imaging, Biopsies, and Biomarkers Room 110 Chairs: Frantisek Saudek, Czech Republic and Michael R. Rickels, United States 740 EFFICACYOFCONTRAST-ENHANCEDULTRASONOGRAPHYFORTHE PREDICTIONOFTHEENDOCRINEFUNCTIONOFTHEGRAFTINCLINICAL PANCREASTRANSPLANTATION Naohiro Aida,Japan 741 HIGHERBASELINELEVELSOFTHEBONEHORMONEUNDERCARBOXYLATED  WEDNESDAY OSTEOCALCININDEPENDENTLYPREDICTIMPROVEDISLETCELL TRANSPLANTATIONOUTCOMES Kirstie K. Danielson,UnitedStates 742 VALIDATIONOFTHEBETA-2SCORE:ANIMPROVEDTOOLTOESTIMATE BETA-CELLFUNCTIONAFTERCLINICALISLETTRANSPLANTATIONFROMA SINGLEFASTINGBLOODSAMPLE shareen Forbes,UnitedKingdom 743 THECLINICALUTILITYOFINFLAMMATORYANDDIABETESMARKERSPOST SIMULTANEOUSPANCREASANDKIDNEYTRANSPLANTATION Hussein A. Khambalia,UnitedKingdom 744 BIOPSIESINPANCREASTRANSPLANTATION:THELAPAROSCOPICAPPROACH Pablo D. Uva,Argentina 745 EVALUATIONOFTHEFUNCTIONOFLIVINGDONORANDGRAFTPANCREAS BYUSING11C-METHIONINEPOSITRONEMISSIONTOMOGRAPHYFOR PANCREASTRANSPLANTATION Kazunori Otsuki,Japan

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746 POST-TRANSPLANTATIONCA19-9LEVELSCORRELATEWITHISLETPURITY ANDLONG-TERMMETABOLICRESULTSAFTERISLETTRANSPLANTATION INTYPE1DIABETES Marie-christine Vantyghem,France 747 CONTRASTENHANCEDULTRASONOGRAPHYINSIMULTANEOUSPANCREAS ANDKIDNEYTRANSPLANTATION Hussein A. Khambalia,UnitedKingdom 748 CONTINUOUSOXYGENDELIVERYIMPROVESOXYGENATIONOF TISSUE-ENGINEEREDISLETGRAFTSINVIVOASMEASUREDWITH FLUORINE-19MAGNETICRESONANCESPECTROSCOPY Bradley P. Weegman,UnitedStates 749 VESICULARNUCLEOTIDETRANSPORTER(VNUT)PROTEINEXPRESSED DURINGTHEINVITRODIFFERENTIATIONOFHUMANINDUCEDPLURIPOTENT STEMCELLSTOINSULINPRODUCINGBETACELLS:APOSSIBLEMARKER FORBETACELLMATURATION Kenneth L. Brayman,UnitedStates

11:00–13:30 Lunch symposium: Prospects for clinical islet Xenotransplantation (ciX) Room 109 Chairs: Bernhard J. Hering, United States and Camillo Ricordi, United States This session is proudly sponsored by Otsuka Pharmaceuticals

750 INTRODUCTION Philip J. O'connell,Australia 751 CURRENTSTATUSOFCLINICALISLETALLOTRANSPLANTATION camillo Ricordi,UnitedStates 752 COMMENTARYONCURRENTSTATUSOFCLINICALISLETALLOTRANSPLANTATION BYCAMILLORICORDI Jose Oberholzer,UnitedStates 753 MICROENCAPSULATEDPORCINEISLETS-WHERETOGOFROMHERE? shinichi Matsumoto,Japan 754 COMMENTARYONMICROENCAPSULATEDPORCINEISLETS-

WEDNESDAY WHERETOGOFROMHEREBYSHINICHIMATSUMOTO susan A. safley,UnitedStates 755 MACROENCAPSULATEDPORCINEISLETS:PRACTICALSTEPSTOREACH CLINICALTRIALS Pierre R. Gianello,Belgium 756 COMMENTARYONMACROENCAPSULATEDPORCINEISLETS: PRACTICALSTEPSTOREACHCLINICALTRIALSBYPIERREGIANELLO tom Loudovaris,Australia 757 GENETICMODIFICATION-WHATISTHEEVIDENCEFORIMPROVEDEFFICACY? Eckhard Wolf,Germany

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758 COMMENTARYONGENETICMODIFICATION-WHATISTHEEVIDENCEFOR IMPROVEDEFFICACY?BYECKHARDWOLF Peter cowan,Australia 759 ANTI-INFLAMMATORYSTRATEGYTOWARDSISLETXENOTRANSPLANTATION takeshi itoh,Japan 760 COMMENTARYONANTI-INFLAMMATORYSTRATEGYFORISLETXENOTRANSPLANTATION  BYTAKESHIITOH shane t. Grey,Australia 761 REGULATIONOFISLETXENOTRANSPLANTATION Emanuele cozzi,Italy 762 COMMENTARYONREGULATIONOFISLETXENOTRANSPLANTATIONBYEMANUELECOZZI Peter G. stock,UnitedStates 763 DISCUSSIONANDCLOSINGREMARKSFROMTHECHAIRS David K. c. cooper,UnitedStates

Lunchboxes will be offered to symposium attendees on a first-come, first-served basis

11:00–12:30 Orals: Hepatocyte transplantation Room 111-112 Chairs: Roberto Gramignoli, Sweden and Kazuo Ohashi, Japan 765 20YEARSOFEXPERIENCEINISOLATIONANDEVALUATIONOFHUMAN HEPATOCYTESFORCELL-BASEDTHERAPY Roberto Gramignoli,Sweden 766 PROLONGEDSURVIVALOFHEPATOCYTESTRANSPLANTEDFOR GLYCOGENSTORAGEDISEASETYPE1B sanghoon Lee,Korea 767 NEONATALDCDLIVERSWITHLONGWARMISCHEMICTIMESCAN PRODUCEGOODQUALITYCLINICALGRADEHEPATOCYTES WEDNESDAY sharon c. Lehec,UnitedKingdom 768 SUPPRESSIONOFTHEINNATEIMMUNERESPONSEUSINGCYTOPTOPICTHERAPEUTIC AGENTSTOPREVENTEARLYCELLLOSSFOLLOWINGHEPATOCYTETRANSPLANTATION charlotte A. Lee,UnitedKingdom 769 HEPATOCYTETRANSPLANTATIONNORMALIZESHYPERCHOLESTEROLEMIAAND AORTICACCUMULATIONOFCHOLESTEROLINAPOLIPOPROTEINEKNOCKOUTMICE carl Jorns,Sweden 770 TWOCASESOFHEPATOCYTETRANSPLANTATIONFORUREACYCLEDISORDERS BYUSINGHEPATOCYTESISOLATEDFROMLIVINGDONORREDUCEDGRAFTS takanobu shigeta,Japan 771 THERAPEUTICEFFECTSOFECTOPICLIVERTISSUEENGINEERINGONLETHAL ACUTELIVERFAILUREINMICE Kazuo Ohashi,Japan 772 THEINFLUENCEOFTHESYNERGISTICEFFECTOFNEUTRALPROTEASEDERIVED FROMCLOSTRIDIUMHISTOLYTICUMANDCLOSTRIPAINONTHEHEPATOCYTEISOLATION satoru Yoshida,Japan 773 IMPROVEMENTOFAMMONIAREMOVALWITHOPTIMIZEDSIZEDOFHEPATOCYTECLUSTER takashi Miyanaga,Japan

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12:30–13:00 Lunch Break (on own) - Exhibits & Poster Viewing

13:30–15:00 Plenary: Paul Lacy Lecture / islet Plenary Plenary 1 Chairs: Bernhard J. Hering, United States, Jon S. Odorico, United States and Paul Johnson, United Kingdom 775 LACYLECTURE:REPLACINGβ-CELLFUNCTION: THELOVEOFALIFETIME(videopresentation) Guido Pozza,Italy 776 PAULE.LACYMEMORIALLECTUREAWARD(videopresentation) Konrad Federlin,Germany 777 EXVIVOEXOCRINECELLREPROGRAMMING Kevin Docherty,UnitedKingdom 778 EPIGENETICREGULATIONOFISLETFUNCTION: THEEFFECTSOFAGINGONTHEBETA-CELLMETHYLOME Maria L. Golson,UnitedStates 779 PLURIPOTENTSTEMCELLDERIVEDBETACELLS timothy J. Kieffer,Canada

15:00–15:30 coffee Break Foyer 1 & 2

15:30–17:00 Orals: islet Quality Assessment and Engraftment Plenary 1 Chairs: Klearchos K Papas, United States and Shinichi Matsumoto, Japan 795 PRELIMINARYRESULTSOFISOLATEDISLETSAFTERHYPOTHERMIC MACHINEPERFUSIONOFHUMANDONORPANCREATA Jason B. Doppenberg,Netherlands 785 EARLYLOSSOFTRANSPLANTEDISLETSISPREVENTEDBYTARGETING RECEPTORFORADVANCEDGLYCATIONENDPRODUCTSOFDONORISLETSINMICE Yasunami Yohichi,Japan 786 DEVELOPMENTOFMICROFLUIDICDEVICESFORISLETPHYSIOLOGY ANDTRANSPLANTATION Yong Wang,UnitedStates 787 GLUCOSEDEPENDENTINSULINSECRETIONRATEAFTERSTANDARDMIXED MEALTESTACCURATELYPREDICTSISLETALLOGRAFTDYSFUNCTIONINVIVO chitrabhanu Ballav,UnitedKingdom WEDNESDAY 788 PROTECTIVEEFFECTOFCYANIDIN-3-O-GLUCOSIDEONXENOTRANSPLANTED NEONATALPORCINEISLETSTHROUGHERK1/2ANDPI3K/AKT-INDUCED NRF2-MEDIATEDHO-1INDUCTION chao Li,People'sRepublicofChina 789 SPHINGOSINEKINASE1ISVITALFORTHEFUNCTIONOFISLETS POSTTRANSPLANTATION Darling M. Rojas-canales,Australia 790 IDENTIFYINGLNCRNASRELATEDTOHUMANβ-CELLFUNCTIONAND SURVIVALINHUMANIZEDMOUSEMODEL Zhiguang Guo,UnitedStates

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791 ANALYSISOFGENEEXPRESSIONINISLETPREPARATIONSRELEASED FORTRANSPLANTATION charlotte Barbieux,Switzerland 792 HUMANIZEDMOUSEMODELWITHHUMANISLETGRAFTFORDETECTING CIRCULATINGHUMANβ CELL-SPECIFICBIOMARKERSRELATEDTOISLET GRAFTREJECTION Zhiguang Guo,UnitedStates 794 EFFECTOFPOTENTIALGLUTATHIONEPRECURSORSONHUMANISLET SURVIVALINHYPOXIA Paul Johnson,UnitedKingdom

15:30 –17:00 Orals: Pancreas & islet Donors: Assessing Risk and Optimizing Outcomes Room 110 Chairs: Takayuki Anazawa, Japan and Sarah E. Cross, United Kingdom 800 MODERNERALONG-TERMPOSTDONATIONOUTCOMESIN46 LIVEPANCREASDONORS Varvara A. Kirchner,UnitedStates 801 THESURVIVALBENEFITOFDONATIONAFTERCARDIACDEATH SIMULTANEOUSPANCREAS-KIDNEYTRANSPLANTATIONINTYPE1DIABETICS Robert R. Redfield iii,UnitedStates 802 ASYSTEMATICREVIEWANDMETA-ANALYSISOFDONATIONAFTER CARDIACDEATH(DCD)PANCREASTRANSPLANTATIONANDTHEPOTENTIAL FORIMPROVINGTHROMBOSISRATESWITHANTE-MORTEMINTERVENTIONS Wayne J. Hawthorne,Australia 803 HYPOTHERMICMACHINEPERFUSIONIMPROVESTHEQUALITYOF MARGINALDONORPANCREATA christina Krikke,Netherlands 804 MACHINEPERFUSIONOFAPANCREASPRIORTOISLETSISOLATION WEDNESDAY ALLOWSTOBETTERISLETSYIELDINCLINICALISLETSTRANSPLANTATION Lukasz Górski,Poland 805 OUTCOMEOFPANCREASTRANSPLANTATIONFROMDECEASEDDONORS INJAPAN-JAPANESEREGISTRYDATA takashi Kenmochi,Japan 806 DONORCHARACTERISTICSOFPANCREASTRANSPLANTSINAUSTRALIAAND NEWZEALAND:ACOHORTSTUDY1984-2014 Patrick J. Kelly,Australia 807 GEOGRAPHICDISTANCEDOESNOTPRECLUDESUCCESSFUL TRANSPLANTATIONACROSSTHEAUSTRALIANCONTINENT Henry Pleass,Australia 808 GOODFUNCTIONALITYBUTLOWERYIELDAFTERISLETISOLATION FROMDONATIONAFTERCIRCULATORYDEATHPANCREATA Jason B. Doppenberg,Netherlands 809 FACTORSSIGNIFICANTLYIMPACTINGISLETYIELDFROMDONORPANCREATA STANDARDIZEDBYTHENORTHAMERICANDONORSCORE:ARETROSPECTIVE STUDYFROMTHEUNIVERSITYOFILLINOISATCHICAGOISLETDATABASE chun chieh Yeh,Taiwan

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15:30–17:00 Orals: solid Organ Xenotransplantation (1) Room 109 Chairs: Richard N. Pierson III, United States and Gilles Blancho, France 810 CRITICALNEEDOFCONTINUOUSCO-STIMULATIONBLOCKADEWITH ANTICD40ANTIBODY(2C10.R4)FORLONG-TERMMAINTENANCEOF GTKO.HCD46.HTBMPIGCARDIACXENOGRAFTSURVIVALINBABOONS Muhammad M. Mohiuddin,UnitedStates 811 HISTOLOGICALEVIDENCEOFACUTEREJECTIONAFTERTERMINATING ANTICD40ANTIBODY(2C10R4)TREATMENTINGTKO.HCD46.HTBMPIGTO BABOONCARDIACXENOGRAFTSSURVIVINGFOROVERONEYEAR Muhammad M. Mohiuddin,UnitedStates 812 CARDIACXENOTRANSPLANTATION:RE-EMERGEDBCELLSAFTER TRANSIENTDEPLETIONBYRITUXANTREATMENTMAINTAINSTHEIR REPERTOIREBUTHAVEAMUTEDIMMUNERESPONSE Avneesh singh,UnitedStates 813 ENHANCEDSURVIVALOFGALTKO/HCD55-HCD59PIGRENALXENOGRAFTS INBABOONS Wayne J. Hawthorne,Australia 814 FACTORSCONTRIBUTINGTOPIGKIDNEYGRAFTSURVIVALINABABOON FOR>4MONTHS Hayato iwase,UnitedStates 815 CD40MABCOSTIMULATIONBLOCKADEIN(LIFE-SUPPORTING)HETEROTOPIC ANDORTHOTOPICCARDIACXENOTRANSPLANTATIONMODELSWITH GALT-KO/HCD46/HTMTRANSGENICDONORPIGSINTOTHEBABOON Paolo Brenner,Germany 816 DIFFERENTIMMUNOSUPPRESSIVEREGIMENSINPRECLINICAL,DISCORDANT XENOGENEIC,HETEROTOPICTHORACICPIG-TO-BABOONHEARTTRANSPLANTATIONS tanja A. J. Mayr,Germany 817 HISTOLOGICALFINDINGSINAHETEROTOPICTHORACICPIG-TO-BABOONCARDIAC XENOTRANSPLANTATIONMODEL tanja A. J. Mayr,Germany 818 THETHREE-YEARSEXPERIENCESOFKIDNEYANDHEARTXENOTRANSPLANTATION OFPIGTONON-HUMANPRIMATE,WHICHISFIRSTTRIALSINKOREA ik Jin Yun,Korea

WEDNESDAY 819 PERIOPERATIVEMANAGEMENTINPRECLINICALPIG-TO-BABOONCARDIAC XENOTRANSPLANTATION Jan-Michael Abicht,Germany 820 COMPLEMENTINHIBITIONBYCOMPSTATINCP40INCREASESCARDIACFUNCTION INAMODELFORPRECLINICALANDCLINICALXENOGENEICTRANSPLANTATIONS Jan-Michael Abicht,Germany

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15:30–17:00 Orals: islet cell transplantation - Miscellaneous Room 111-112 Chairs: Maria Koulmanda, United States and Francesco L. Ierino, Australia 825 TOWARDSTHERAPEUTICAPPLICATIONOFREGULATORYTCELLS: CLINICALGRADEISOLATION,EXVIVOEXPANSIONANDCRYOPRESERVATION Karolina M. Golab,UnitedStates 826 EFFECTOFPHORBOLESTERINACTINREMODELLINGOFECADHERIN–MEDIATED  ADHESIONOFHUMANBETA-CELLS Estelle Brioudes,Switzerland 827 ACUTEISCHEMICEXPOSURELEADSTOFUNCTIONALDEFICITSANDA TRANSCRIPTOMEENRICHEDININFLAMMATORYANDHYPOXIC PATHWAYSINHUMANISLETS Kate smith,UnitedStates 828 AMINOACIDSUPPLEMENTATIONPREVENTSISLETCELLSDEATHFROM NUTRIENTDEPRIVATIONDURINGTHEPERI-TRANSPLANTPERIOD Gaetano Faleo,UnitedStates 829 EMBRYONICSTEMCELLDIFFERENTIATIONINTOINSULIN-PRODUCING CELLS(IPCS):FUNCTIONALCHARACTERIZATIONOFTHEPURKINJECELL PROTEIN4(PCP4)GENEINTHISPROCESS Patricia M. Kossugue,Brazil 830 DEVELOPMENTOFANEWPROCUREMENTPROTOCOLFORHUMANPANCREAS AIMEDATTHEGENERATIONOFDECELLULARIZEDPANCREATICSCAFFOLDS talita s. carmo,Brazil 831 IMPROVEDSURVIVALANDBETTERENGRAFTMENTOFHUMANMYOGENIC RESERVECELLS,ASCOMPARETOHUMANMYOBLASTS,AFTERINTRAMUSCULAR TRANSPLANTATIONINIMMUNODEFICIENTMICE thomas Laumonier,Switzerland WEDNESDAY 832 SUCCESSFULHUMAN-TO-NONHUMANPRIMATEPANCREATICISLETINTRAPORTAL XENOTRANSPLANTATIONUSINGAHUMANALLO-BASEDIMMUNOSUPPRESSIONREGIMEN James J. McGarrigle,UnitedStates 833 STIMULATIONOFPORCINEBETA-CELLPROLIFERATIONISINHIBITEDWITHHYPOXIC CULTURECONDITIONS Melissa A. Davis,UnitedStates 834 TRACKINGHUMANREGULATORYTCELLS(TREG)INAHUMANIZEDMOUSEMODELOF PORCINEISLETXENOTRANSPLANTATION Fei Guo,Australia

17:00–17:30 cts BUsiNEss MEEtiNG (society info on page 9) Room 111-112

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17:30–18:30 Poster: Joint Poster session Foyer 1 & 2 CELL TRANSPLANT TRACK 840 CONSTRUCTIONOFACELLCONTAINING,THREE-DIMENSIONAL RECONSTITUTEDALIGNEDCOLLAGENFIBRILSCAFFOLDINASINGLESTEP shiao-Wen tsai,Taiwan 843 RAPAMYCIN/GABACOMBINATIONTREATMENTREVERSESDIABETESINNODMICE Bole tian,People'sRepublicofChina 845 ROLEOFMESENCHYMALSTROMALCELLSINTHEPREVENTIONOFCELLDEATH ANDIMPROVEMENTOFMETABOLISMINHUMANPRIMARYHEPATOCYTES: FOCUSONMICRO-RNAEXPRESSIONREGULATION celine Filippi,UnitedKingdom 846 HOWTOUSEPRESERVATIONOFRATHEPATOCYTESFORCELLTRANSPLANTATION? Masahiro ito,Japan 848 AMNIOTICEPITHELIALCELLSDIFFERENTIATEINTOHEPATICSINUSOIDAL ENDOTHELIALCELLSINVIVO Fabio Marongiu,Italy 849 THEEFFICACYOFSPHEROIDALHEPATOCYTEONHEPATOCYTETRANSPLANTATION Masaaki Watanabe,Sweden 850 CHARACTERIZATIONANDOPTIMIZATIONOFENZYMECOMPONENTSFOR HEPATOCYTEISOLATION satoru Yoshida,Japan 851 METABONOMICANALYSISOFTHETHERAPEUTICEFFECTOFMESENCHYMAL STEMCELLSINARATMODELOFDIABETICNEPHROPATHY Jingping Liu,People'sRepublicofChina 852 ELASTIN-LIKEEXTRACELLULARMATRIXINDUCESERKANDAKTSIGNAL TRANSDUCTIONANDPROMOTESNEURONALPROGENITORCELLSURVIVAL ANDPROLIFERATION Jung-Hee Kim,Korea 854 EFFECTOFMELATONINTOHORMONEANDOVULATIONINPREOVULATORYCANINE seunghoon Lee,Korea PANCREAS AND ISLET TRACK 855 ANGIOTENSIN-(1-7)CYTOPROTECTIVEEFFECTSONPANCREATICISLETSANDITS 

WEDNESDAY THERAPEUTICPOTENTIALINDIABETESMELLITUS Ana Lucia campanha-Rodrigues,Brazil 856 ASMALLMOLECULEINHIBITOROFTOLL-LIKERECEPTOR-4(TLR-4)EFFECTIVELY  PROTECTSISLETSFROMIBMIR Bashoo Naziruddin,UnitedStates 857 ELEVATEDCASPASE3ACTIVATIONLEVELSINTHEPANCREAS:APOTENTIALLY USEFULPREDICTOROFISLETISOLATIONOUTCOME Elisa Maillard Pedracini,France

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859 PRLPROTECTIONOFBETA-CELLGENERALDAMAGERESTOREAUTOPHAGYMARKERS Letícia F. terra,Brazil 860 PRL-INDUCEDCYTOPROTECTIVEANDMETABOLICBENEFICIALEFFECTS AREMEDIATEDBYHSPB1ONBETA-CELLS Rosangela A. M. Wailemann,Brazil 861 BIOLOGICIMPLANTASAREPAIRTOOLINPANCREASTRANSPLANTATION-RELATED  NECROTICABDOMINALWALLDEFICIENCY Andrzej Berman,Poland 862 PRE-EMPTIVEARTERIALSTENTINGWITHCOVEREDVASCULARSTENTS TOPREVENTMYCOTICHAEMORRHAGEININFECTEDFIELDSAFTER FAILEDPANCREASTRANSPLANTS Petros Yiannoullou,UnitedKingdom 864 IMPACTOFDIABETICGASTROPARESISONOUTCOMESAFTER PANCREASTRANSPLANTATION Jonathan A. Fridell,UnitedStates 865 PANCREASTRANSPLANTATIONWITHOUTREVASCULARIZATIONOFTHE SPLENICARTERY Rune Horneland,Norway 866 APROPOSALOFNEWMARGINALDONORCRITERIAFORPANCREAS TRANSPLANTATIONINJAPAN taihei ito,Japan 867 CLINICALOUTCOMEOFBKVIRUSASSOCIATEDNEPHROPATHYIN SIMULTANEOUSPANCREASANDKIDNEYTRANSPLANTRECIPIENTS Joo Hee Jung,Korea 868 USINGTHETERMINALILEUMFOREXOCRINEDRAINAGEINPANCREAS TRANSPLANTATION–ASAFEANDEFFECTIVETECHNIQUE Hussein A. Khambalia,UnitedKingdom WEDNESDAY 869 SIMULTANEOUSDECEASED-DONORPANCREAS,LIVING-DONORKIDNEY TRANSPLANTATION:SINGLECENTEREXPERIENCE YoungHoon Kim,Korea 870 EXCESSIVEWEIGHTGAINAFTERPANCREASTRANSPLANT:ARISKFOR METABOLICSYNDROME,FATTYLIVERDISEASEANDTYPE2DIABETES Richard J. Knight,UnitedStates 871 LONGTERMDURABILITYOFGLYCEMICCONTROLAFTER PANCREASTRANSPLANTATION Yogish c. Kudva,UnitedStates 872 THEIMPACTOFPREOPERATIVECARDIOVASCULARINTERVENTIONSON OUTCOMEAFTERPANCREASTRANSPLANTATION Jerome M. Laurence,Canada

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873 ARTERIALSTENOSISOFTHEPANCREATICGRAFTMIGHTBEASSOCIATED WITHACUTECELLULARREJECTIONINPANCREASTRANSPLANTATION Kvetoslav Lipar,CzechRepublic 874 IMMUNOLOGICREJECTIONOFADENOVOMETASTATICDONOR-DERIVED BELLINIDUCTCARCINOMAINAKIDNEYTRANSPLANTRECIPIENT Raphael P. H. Meier,Switzerland 875 ABDOMINALWALLRECONSTRUCTIONFORLARGEVENTRALHERNIAEAFTER PANCREASTRANSPLANTATION:ASINGLECENTREEXPERIENCE Zia Moinuddin,UnitedKingdom 876 GLYCOSYLATEDHEMOGLOBINA1CASATOOLFORASSESSINGPOST-TRANSPLANT COMPLIANCEINTHEEVALUATIONOFDIABETICPATIENTSFORTRANSPLANTATION Oyedolamu K. Olaitan,UnitedStates 877 PANCREASGRAFTFROMTHEDONORWITHOUTACCEPTABLELIVER PROCUREMENTISPROBABLYUTILIZEDFORTRANSPLANTATIONDESPITE THEDECREASEDPANCREASGRAFTFUNCTION Minoru Oshima,Japan 878 INCIDENCEOFSURGICALSITEINFECTIONSINPANCREASTRANSPLANTRECIPIENTS Agata Ostaszewska,Poland 879 ADVANTAGEOFSYSTEMATICPERFORMINGBOTHBKVVIREMIASCREENING ANDKIDNEYPROTOCOLBIOPSYAMONGSPKTXRECIPIENTSBASEDONTHE CASEOFONEPATIENT Andrzej Berman,Poland 880 ENDOVASCULARSALVAGEOFAPANCREASALLOGRAFTHAVINGDEVELOPED ALARGEAVFISTULAANDANEURYSM Andrew L. singer,UnitedStates 881 SINGLECENTREAUDITOFLONG-TERMOUTCOMESINPATIENTSWITHTYPE1 DIABETESMELLITUSRECEIVINGSIMULTANEOUSPANCREASANDKIDNEY  TRANSPLANTATION(SPK)VERSUSKIDNEYALONE–AVAILABILITYOFLOCALSPK PROGRAMPOTENTIALLYINFLUENCESSELECTIONFORSPK Jessica L. stranks,Australia 882 REASONSFORPANCREASNON-RETRIEVAL:APOTENTIALLYWASTEDRESOURCE? Kiane J. Zhou,Australia 884 ADAPTIVECAPACITYOFHUMANISLETSTODIETINDUCEDOBESITYINVIVO: OLDNORMALBMIANDOLDOBESEDONORISLETSRETAINFUNCTIONALAND

WEDNESDAY MASSADAPTATIONCOMPAREDTOYOUNGDONORS,BUTNOTOLD SUPEROBSE(BMI>40)DONORISLETS Julie Kerr-conte,France 885 THEEFFECTOFHIGHGLUCOSEONEXPRESSIONOFTHIOREDOXIN-INTERACTING  PROTEINANDINTERLUEKIN-22ONHUMANISLETSSURVIVALANDFUNCTION INVITROANDINVIVO shadab Abadpour,Norway

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886 SIRT-1OVER-EXPRESSEDTRANSGENICMICEUSINGPODOCINPROMOTER COULDIMPROVETHESUCCESSRATEOFPANCREATICISLETTRANSPLANTATION Jai Won chang,Korea 887 ISLETHEPARANSULFATE(HS)UNDERGOESOXIDANT-MEDIATEDLOSSDURING ISLETISOLATIONANDRECOVERSSLOWLYAFTERISLETTRANSPLANTATION Fui Jiun choong,Australia 888 CONTROLLINGOFCO-STIMULATORYSIGNALSUSINGPD-L1FCFUSIONPROTEIN ANDANTI-CD154ANTIBODYPROLONGSISLETALLOGRAFTSURVIVALSYNERGISTICALLY Hwajung H. Kim,Korea 889 SURVIVALOFSUBCUTANEOUSISLETTRANSPLANTINHYPEROXIA Hirotake Komatsu,UnitedStates 890 ELASTINANALOGOUSPROTEINENHANCESPANCREATICISLETSURVIVALAND AMELIORATESHYPERGLYCEMIAINSTREPTOZOTOCIN-INDUCEDDIABRETIC MICEBYMODULATINGPI3K/AKT/FOXO1 Kyeong-Min Lee,Korea 892 INTRA-OMENTALIMPLANTATION:APROMISINGNOVELTECHNIQUEFOR ISLETSTRANSPLANTATION Elisa Maillard Pedracini,France 893 COMPARISONOFADULT,JUVENILEANDNEONATALPORCINEISLETS DEMONSTRATESAGEDEPENDENTBETA-CELLFRACTION,INSULINCONTENT ANDINSULINSECRETION catherine Min,UnitedStates 894 INSULINSECRETIONDATAANALYSISOFHUMANISLETPREPARATIONS Estelle Brioudes,Switzerland 895 B10CELLSPLAYAROLEINTHEIMMUNEMODULATIONOFPRO-AND ANTI-INFLAMMATORYIMMUNERESPONSESINMOUSEISLETALLOGRAFTREJECTION Mei Zhang,People'sRepublicofChina WEDNESDAY 896 ENHANCEMENTOFPRE-TRANSPLANTIN-VITROCULTUREOFHUMANPANCREATIC ISLETSBYSUPPLEMENTATIONWITHHUMANENDOTHELIAL-DERIVEDEXOSOMES camillo Ricordi,UnitedStates 897 THELIPIDOMEOFPANCREATICISLETS–BIOMARKERFORISLETQUALITYANDFUNCTION? Janine schmid,Germany 898 STIMULATIONOFISLETREVASCULARIZATIONMODULATINGHIF-1α EXPRESSIONUSINGSIPHD3 séverine sigrist,France 899 IMPACTOFHYPERGLYCEMIAONISLETSREVASCULARIZATIONDEFICIENCY POSTINTRAPORTALETRANSPLANTATION séverine sigrist,France 900 DESIGNINGANOVELARTIFICIALTRANSPLANTATIONSITEFORHUMAN PANCREATICISLETS Alexandra M. smink,TheNetherlands

November 15–19, 2015 | Melbourne, Australia 87 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 18 IPITA IXA CTS Joint

901 INVITROCOMPARISONOFADULT,JUVENILE,ANDNEONATALPORCINE ISLETSREVEALSAGEDEPENDENTRESISTANCETOISCHEMIA Kate smith,UnitedStates 902 PANCREASDERIVEDMESENCHYMALSTEMCELLIMPROVETHEGLUCOSE RESPONSEOFTRANSPLANTEDISLETSMOREEFFECTIVELYTHANADIPOSE TISSUEDERIVEDSTEMCELLS Gumpei Yoshimatsu,UnitedStates 903 DEVELOPMENTOFTHEAUTOLOGOUSISLETTRANSPLANTATIONMODEL WITHMINIATURESWINE Zhengkun Zhang,Japan 904 EFFECTOFALPHA-CELLSONRATINSULINSECRETION charlotte Barbieux,Switzerland 905 ASYMMETRICDISTRIBUTIONOFDELTAANDPPCELLSWITHINHUMAN PANCREATICISLETS charlotte Barbieux,Switzerland 906 L-ARGININESUPPLEMENTATIONIMPROVESINSULINSENSITIVITYANDBETACELL FUNCTIONINOFFSPRINGSOFDIABETICMOTHERSTHROUGHAKTANDPDX-1ACTIVATION Aparecida E. Hirata,Brazil 907 EVALUATIONOFLAMININEXPRESSIONANDBASEMENTMEMBRANEINTEGRITYIN ISOLATEDHUMANANDJUVENILEPORCINEISLETS Jonathan R. t. Lakey,UnitedStates 908 PROTECTIONOFNECROSTATIN-1ONPREVENTIONTHEDAMAGEOFPANCREAS ISLETCELLINDUCEDBYTNF-α INVITRO Xiaoqian Ma,People'sRepublicofChina 909 CULTURINGNEONATALISLETCELLCLUSTERSINEGM2MEDIUM–APRACTICABLE APPROACHTOIMPROVEISLETXENOTRANSPLANTATIONOUTCOME Xiaoqian Ma,People'sRepublicofChin 910 BETA-CELL-SPECIFICEXPRESSIONOFGLUCAGON-LIKEPEPTIDE1(GLP-1)AND ACTIVATEDMUSCARINICRECEPTOR(M3R)IMPROVESPIGISLETSECRETORYFUNCTION Nizar i. Mourad,Belgium 911 REVEALINGACRITICALCROSS-TALKBETWEENBETAISLETCELLSANDTHE VASCULATUREINDIABETES Kay K. Myo Min,Australia 912 SUBSTANCEPINDUCESANGIOPOIETIN1GENEEXPRESSIONINHUMANISLETS WEDNESDAY ANDPROMOTESTHEIRSURVIVALINCULTURE Darling M. Rojas-canales,Australia 913 PARTIALPANCREATECTOMYINDUCESBETACELLREGENERATIONIN CYNOMOLGUSMONKEY Du Yeon shin,Korea

88 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 18 IPITA IXA CTS Joint

914 THEINFLUENCEOFPREVIOUSPREGNANCYONTHEFUNCTIONALITYOF SMALLERANDLARGERRATISLETS Anja steffen,Germany 915 INTRODUCINGOXYGENCONSUMPTIONRATEASAQUALITYCONTROLTOOL FORRESEARCHANDCLINICALISLETPREPARATIONS Michaela Waibel,Australia 916 ASURFACETENSIONDRIVENPUMPLESSMICROFLUIDICDEVICEFOR PANCREATICISLETRESEARCH Yong Wang,UnitedStates 917 ASTUDYONTHETOXICITYOFTRIPTOLIDEONNEONATALPORCINEISLET CELLSINVITRO Xiaoqian Ma,People'sRepublicofChina 918 HUMANADIPOSETISSUE-DERIVEDSTEMCELLSENHANCESURVIVALAND FUNCTIONOFGRAFTEDISLETSINCO-TRANSPLANTEDDIABETICMICE Byung-Joon Kim,Korea 919 THEINSULINRECEPTORANTAGONISTS961INDUCESMINIMALPROLIFERATIONOF  PANCREATICBETACELLSINNON-HUMANPRIMATES christian s. schuetz,UnitedStates XENOTRANSPLANTATION TRACK 920 PRODUCTIONOFKNOCK-INTRANSGENICMINIATUREPIGSEXPRESSINGHUMAN CD39ONALPHA1,3-GALACTOSYLTRANSFERASE(GGTA1)GENELOCUS Kimyung choi,Korea 921 EFFICIENTGENERATIONOFGAL-KOCELLLINESFORSCNTBYSELECTION WITHBIOTIN-CONJUGATEDIB4-LECTINATTACHEDTOSTREPTAVIDIN-COATED MAGNETICBEADS cesare Galli,Italy

922 DISCOVERYANDIMPLEMENTATIONOFNOVELPIGGENOTYPESUSINGADVANCED WEDNESDAY GENOMETECHNOLOGIESWITHINCREASEDSURVIVALINPRIMATES Marc Guell,UnitedStates 923 PRODUCTIONOFTALEN-MEDIATEDGENE-MODIFIEDPIGSVIASOMATIC CELLNUCLEARTRANSFER Geon A. Kim,Korea 924 EFFICIENTAPPROACHFORISOLATIONOFα-GALDEFICIENTPORCINE FIBROBLASTSEXPRESSINGHUMANDAFANDCD39USINGCRISPR/CAS9 Young June Kim,Korea 925 PRODUCTIONOFALPHA1,3-GALACTOSYLTRANSFERASEANDCYTIDINE  MONOPHOSPHATE-N-ACETYLNEURAMINICACIDHYDROXYLASEGENE DOUBLE-KNOCKOUTPIGSBYGENOMEEDITINGANDSOMATICCELLCLONING Hitomi Matsunari,Japan

November 15–19, 2015 | Melbourne, Australia 89 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 18 IPITA IXA CTS Joint

926 GENERATIONOFHUMANCD73EXPRESSINGPIGUNDERCONTROLOF PORCINEICAM-2PROMOTER Keon B. Oh,Korea 927 PRODUCTIONOFATRANSGENICHPD-L1PIGFORXENOTRANSPLANTATION WITHTHESLEEPINGBEAUTYTRANSPOSONSYSTEM Bjoern Petersen,Germany 928 TARGETINGTHEPD-1-PD-LIGANDINHIBITORYPATHWAYINTRANSGENICPIG FORXENOTRANSPLANTATION Bjoern Petersen,Germany 929 MODIFYINGPIGSTOOVERCOMEBARRIERSTOXENOTRANSPLANTATION Beate Rieblinger,Germany 930 THESURVIVALRATEOFPBMCSFROMGGTA1KNOCKOUTPIGSGENERATEDBY TALENORCRISPR/CAS9VECTORUNDERFORMOSANMACAQUESSERUMCHALLENGES Hao-chih tai,Taiwan 931 GENERATIONOFKNOCKOUTPIGSUSINGDIRECTLYPRONUCLEARMICROINJECTION WITHGGTA1TALENPLASMIDDNAS ching-Fu tu,Taiwan 932 COMPARISONOFDIRECTLYPRONUCLEARMICROINJECTIONWITH1SITEOR4 SITESRNAPOLYMERASEIIIPROMOTER-GGTA1CRISPR/CAS9PLASMIDDNAS TOGENERATEKNOCKOUTPIGS tien-shuh Yang,Taiwan 933 EX-VIVOPERFUSIONOFALPHA-GALKNOCKOUT,HCD46/HLA-EDOUBLE TRANSGENICPIGHEARTS Jan-Michael Abicht,Germany 934 EFFECTSOFATHROMBOXANESYNTHASEINHIBITOR,1-BIA,ONEICOSANOID METABOLISMINAGALTKO.HCD46XENOGENEICLUNGPERFUSIONMODEL Lars Burdorf,UnitedStates 935 ANALYSESOFHUMAN,MONKEY,ANDPIGCOAGULATION-RELATEDPROTEINS MAYREVEALTHEMOLECULARMECHANISMSOFCOAGULATIONDYSREGULATION INXENOTRANSPLANTATION Pengfei chen,People'sRepublicofChina 936 EFFICIENTRECONSTRUCTIONOFTALENS-MEDIATEDGGTA1KNOCKOUTDIANNAN  MINIATUREPIGSFORXENOTRANSPLANTATION Hongjiang Wei,People'sRepublicofChina WEDNESDAY

90 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org NOTES

November 15–19, 2015 | Melbourne, Australia 91 IPITA • IXA • CTS | www.melbourne2015.org NOTES

92 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 19 IPITA IXA CTS Joint

07:00–09:00 Workshop: Biofabrication Part 1: implantable Additive Biofabrication Room 109 technologies for structural and Functional tissue Applications This session is proudly sponsored by ARC Center for Excellence

1000 BIOFABRICATIONFOREMERGINGTECHNOLOGIES Gordon Wallace,Australia

Breakfast will be served to workshop attendees; pre-registration was required

08:00–09:00 state-of-the-Art Workshop: islet Autotransplantation Plenary 1 Chairs: David E.R. Sutherland, United States and Pratik Choudhary, United Kingdom 1005 EXPANDINGINDICATIONSFORISLETAUTOTRANSPLANTATION Lorenzo Piemonti,Italy 1006 CORRELATESOFSUCCESSFULOUTCOMESAFTERISLETAUTOTRANSPLANTATION Melena D. Bellin,UnitedStates 1007 LONGTERMOUTCOMESOFISLETAUTOTRANSPLANTATION Horacio L. Rilo,UnitedStates 1008 PATIENTSATISFACTIONANDCOST-EFFECTIVENESSOFISLETAUTOTRANSPLANTATION Ashley Dennison,UnitedKingdom

08:00–09:00 state-of-the-Art Workshop: Glycosylation & Non-Gal Xenoantigens Room 110 Chairs: Mauro S. Sandrin, Australia and Chris Burlak, United States 1010 NEWNON-GALXENOANTIGENS Guerard W. Byrne,UnitedKingdom 1011 ANTI-GALAND-NONGALANTIBODIESTOECMIMPLANTS Uri Galili,UnitedStates 1012 THEBCELLIMMUNERESPONSETOGLYCANANTIGENS Lori J. West,Canada 1013 NEWMETHODSTOINHIBITTHEANTI-NONGALRESPONSE Mary Kearns-Jonker,UnitedStates

08:00–09:00 state-of-the-Art Workshop: Regenerative Medicine, Aging and Disease Room 111-112

Chair: Ewa C. Ellis, Sweden THURSDAY 1015 CENTRALNERVOUSSYSTEM Evan Y. snyder,UnitedStates 1016 MUSCLE-DERIVEDSTEMCELLS Johnny Huard,UnitedStates 1017 TRANSLATIONALCHALLENGESINREGENERATIVEMEDICINE Alan O. trounson,Australia

November 15–19, 2015 | Melbourne, Australia 93 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 19 IPITA IXA CTS Joint

09:00–10:30 Plenary: Joint Presidential session / Plenary 1 Best Young investigators scientific Awards / 2017 Host cities Presentations 1023 INTRODUCTIONBYTTSPRESIDENT Philip J. O'connell,Australia 1020 PREsiDENtiAL ADDREss iPitA Bernhard J. Hering,UnitedStates 1021 PREsiDENtiAL ADDREss cts Maria Koulmanda,UnitedStates 1022 PREsiDENtiAL ADDREss iXA takaaki Kobayashi,Japan 1027 PRESENTATIONOFBESTYISCIENTIFICAWARDS 1024 PRESENTATIONOFIXA2017CONGRESS Richard N. Pierson iii,UnitedStates 1025 PRESENTATIONOFIPITA2017CONGRESS Paul Johnson,UnitedKingdom 1026 PRESENTATIONOFCTS2017CONGRESS steven Paraskevas,Canada

10:30–11:00 coffee Break Foyer 1 & 2

11:00–12:30 Orals: topics in Experimental and clinical islet transplantation Plenary 1 Chairs: Ekaterine Berishvili, Switzerland and Balamurugan N. Appakalai, United States 1030 ANOVEL,NON-VIRALMRNADELIVERYSYSTEMFORTARGETEDPROTEIN TRANSLATIONINHUMANISLETS Jose Oberholzer,UnitedStates 1032 USING3-DIMENSIONALOPTICALPROJECTIONTOMOGRAPHYTOSTUDY β-CELLMASSINDIABETES Jingjing Ge,Australia 1033 ISLETSALLOTRANSPLANTATIONINTOGASTRICSUBMUCOSAINCASEOF PORTALHYPERTENSION Michał Wszoła,Poland 1034 ELISPOTASSESSMENTOFCELLULARIMMUNEALLOREACTIVITYINCLINICAL ISLETTRANSPLANTRECIPIENTS Elvira Jimenez Vera,Australia 1035 MICRORNA375EXPRESSIONINJUVENILEPORCINEISLETSDURING PROLONGEDINVITROCULTURE Jonathan R.t. Lakey,UnitedStates 1036 PROINFLAMMATORYRESPONSESINDUCEDBYSERUMDEPRIVATIONDURING EXVIVOCULTUREAFTERISLETISOLATION:ROLEOFIL-1BLOCKADEANDHIAPP sang-Man Jin,Korea THURSDAY

94 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 19 IPITA IXA CTS Joint

1037 INCIDENCEOFDENOVOHLAANTIBODIESFOLLOWINGISLETTRANSPLANTALONE: IMPACTONOUTCOMEANDRE-TRANSPLANTATION Paul Johnson,UnitedKingdom 1038 EFFECTSOFETANERCEPTROUTEOFADMINISTRATIONINCLINICAL ALLOGENEICISLETTRANSPLANTATION:ANANALYSISFROMTHECOLLABORATIVE ISLETTRANSPLANTREGISTRY(CITR) christopher J. Drogemuller,Australia

1039 HUMANADIPOSETISSUEDERIVEDSTEMCELLSINCUBATEDIN1%O2 INCREASE  SECRETIONOFISLETPROTECTIVEFACTORS,IMPROVESFUNCTIONANDREDUCES  APOPTOSISINHUMANISLETINVITRO simen W. schive,Norway

11:00–12:30 Orals: islet isolation and survival Room 110 Chairs: Barbara Ludwig, Germany and Fouad R. Kandeel, United States 1040 STIMULATIONOFHUMANINTRAISLETENDOTHELIALCELLSYIELDS PERI-ISLETCAPILLARIES:ROLEOFADIPOSE-DERIVEDSTROMALVASCULAR FRACTIONCELLSANDECGSSOLUTION Gopalakrishnan Loganathan,UnitedStates 1041 ADENOSINEIMPROVESHUMANISLETSURVIVALINAHYPOXICENVIRONMENT Paul Johnson,UnitedKingdom 1042 BOTHLAYERSOFTHEHUMANISLETDOUBLEBASEMENTMEMBRANEARE SUBSTANTIALLYDISRUPTEDDURINGISLETISOLATION sarah E. cross,UnitedKingdom 1043 NORTHAMERICAISLETDONORSCOREINDONORPANCREASSELECTIONFOR  SUCCESSFULISLETISOLATIONFORTRANSPLANTATION–AMULTICENTERSTUDY Ling-jia Wang,UnitedStates 1044 HIGHRESOLUTIONDETECTIONOFISLETDAMAGEBYMICRORNA-375DURING ANDAFTERHUMANISOLATIONPROCEDURES Bashoo Naziruddin,UnitedStates 1045 COVALENTLYBOUNDISLETSURVIVALFACTORSTOTISSUECULTURESURFACES MAINTAINTHEIRBIOLOGICALACTIVITY Daniella Penko,Australia 1046 ASUCCESSFULCLINICALISLETISOLATIONSERVICEUSINGNORMOTHERMIC PURIFICATION:A5YEAROVERVIEWOF121ISOLATIONSUTILISINGPANCREATA FROMDBDANDDCDDONORS Alan timpson,UnitedKingdom THURSDAY 1047 ADVANCESINHUMANISLETPROCESSINGTOWARDSSTABLEAND PREDICTABLEOUTCOMES David W. scharp,UnitedStates 1048 CO-CULTUREWITHEXTRACELLULARMATRIXPROTEINSREDUCES HYPOXIA-INDUCEDHUMANISLETCELLDEATH sarah E. cross,UnitedKingdom 1049 PANCREASOXYGENGASPERFUSION(PERSUFFLATION)DURINGPRESERVATION  IMPROVESCLINICALISLETISOLATIONYIELDSANDSUCCESSRATES Klearchos K. Papas,UnitedStates

November 15–19, 2015 | Melbourne, Australia 95 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 19 IPITA IXA CTS Joint

11:00–12:30 Orals: solid Organ Xenotransplantation (2) Room 109 Chairs: Muhammad M. Mohiuddin, United States and Burcin Ekser, United States 1050 NEWMULTI-TRANSGENICDONORPIGSANDTARGETEDDRUGTREATMENTS EXTENDEDLIFE-SUPPORTINGXENOGENEICLUNGFUNCTION Lars Burdorf,UnitedStates 1051 THEEFFECTOFHUMANLEUKOCYTEANTIGEN-EEXPRESSIONON GALTKO.HCD46LUNGXENOGRAFTSURVIVALANDINJURYINAN EX-VIVOXENOPERFUSIONMODEL chris t. Laird,UnitedStates 1052 EFFECTSANDMECHANISMSOFCARBONMONOXIDEONREDUCINGHYPERACUTE  DYSFUNCTIONANDMICROANGIOPATHYINGALT-KOPULMONARYXENOTRANSPLANTATION Hisashi sahara,Japan 1053 REGULATIONOFCOAGULATIONANDFIBRINOLYSISDURINGLIVERPERFUSIONEXVIVO Arielle cimeno,UnitedStates 1054 DEVELOPMENTOFANOVELCIRCUITFORPHYSIOLOGICXENOPERFUSIONOF PORCINELIVERSWITHFRESHWHOLEHUMANBLOOD Dawn M. Parsell,UnitedStates 1055 IL-8ELABORATIONMAYCONTRIBUTETOGALTKO.HCD46LUNG XENOGRAFTINFLAMMATION Beth M. French,UnitedStates 1056 MULTIPLEXPROFILINGOFPLASMAPROTEINSAFTERXENOGENEICLUNGEXPOSURE Agnes M. Azimzadeh,UnitedStates 1057 EFFECTOFC5AINHIBITIONONGALTKO.HCD46PIGLUNGXENOGRAFTPERFUSION Lars Burdorf,UnitedStates 1058 CARDIACXENOTRANSPLANTATION:ROLEOFCD4+CD25HIFOXP3+TREGULATORY CELLSINLONG-TERMCARDIACXENOGRAFTSURVIVORS Avneesh singh,UnitedStates 1059 GALTKO.HCD46+/+.NEU5GCKOPORCINELIVERSPRESERVEPLATELETCOUNTS DURINGEXTRA-CORPOREALPERFUSIONWITHHUMANBLOOD Mehmet c. Uluer,UnitedStates 1060 THERAPEUTICREGULATIONOFSYSTEMICINFLAMMATIONINXENOGRAFT RECIPIENTS(SIXR)INTHEABSENCEOFANADAPTIVEIMMUNERESPONSE David K.c. cooper,UnitedStates THURSDAY

96 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 19 IPITA IXA CTS Joint

11:00–12:30 Orals: tissue Engineering and stem cell Differentiation Room 111-112 Chairs: Séverine Sigrist, France and Clark K. Colton, United States 1065 HEPATOCYTETRANSPLANTATIONFORTHEASSESSMENTOFHEPATOCYTE STREAMINGANDPROLIFERATION Kazuo Ohashi,Japan 1066 INSITUOXYGENDELIVERYTOISLETSWITHINANIMPLANTABLEIMMUNOISOLATING  DEVICEINVIVOENHANCESVIABILITYANDFUNCTION Leah V. steyn,UnitedStates 1067 CONTROLLEDREASSEMBLYOFHUMANDONORISLETCELLSINTOWELL-DEFINED ORGANOIDSRESULTSINGLUCOSE-RESPONSIVEANDFUNCTIONALPSEUDOISLETS INVITRO,CAPABLEOFC-PEPTIDEPRODUCTIONINAMOUSEKIDNEYCAPSULE  TRANSPLANTMODEL Aart A. van Apeldoorn,TheNetherlands 1068 INTRACARDIALLYINJECTEDNEURALCRESTSTEMCELLSHOMETOTHEPANCREAS ANDDELAYSDISEASEPROGRESSIONINANANIMALMODELFORTYPE1DIABETES Liza E. Grapensparr,Sweden 1069 WNTSIGNALINGINPANCREATICPROGENITORANDBETACELLGROWTH solomon Afelik,UnitedStates 1070 DEVELOPMENTOFCELLMANIPULATIONDEVICEUSINGSHARPTIPELECTRODE APPLIEDALTERNATINGCURRENTELECTRICFIELDFORCELLTRANSPLANTATION Hiromichi Obara,Japan 1071 INCREASINGISLETDENSITYWITHINANIMMUNOISOLATIONDEVICEHASA DETRIMENTALIMPACTONVIABILITYINVIVO Leah V. steyn,UnitedStates 1072 PRECONDITIONEDHMSCSANDHUVECSBOOSTREVASULARISATIONOF HUMANISLETSINASUBCUTANEOUSTRANSPLANTATIONSITE Aart A. van Apeldoorn,TheNetherlands 1073 CO-CULTUREWITHPRIMARYLIVERCELLSIMPROVESMATURATIONAND DIFFERENTIATIONOFHUMANINDUCEDPLURIPOTENTSTEMCELLS-DERIVED  HEPATOCYTE-LIKECELLS Robert Fisher,UnitedStates

12:30–13:30 Lunch Break (on own) THURSDAY

November 15–19, 2015 | Melbourne, Australia 97 IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 19 IPITA IXA CTS Joint

13:30–15:00 symposium: Pancreas & islet Allotransplantation: Plenary 1 towards Unifying Beta cell Replacement therapy Chairs: Peter J. Friend, United Kingdom and Paola Maffi, Italy 1075 PATIENTSELECTIONFORALLOISLETVS.ALLOPANCREAS thierry Berney,Switzerland 1076 WHOLEPANCREASVS.ISLETS-WHOSHOULDGETWHICHPANCREAS? Paul Johnson,UnitedKingdom 1077 MEASURINGFUNCTIONANDDEFININGSUCCESSINWHOLEPANCREASANDISLETS Jon s. Odorico,UnitedStates 1078 ISITTIMEFORACOMPARATIVETRIALOFWHOLEPANCREASVS.ISLETS? Raja Kandaswamy,UnitedStates

13:30–15:00 symposium: Zoonosis & Regulation Room 110 Chairs: Chung-Gyu Park, Korea and Philip J. O'Connell, Australia 1080 SCREENINGFORPERVANDKNOWNPATHOGENS Linda scobie,UnitedKingdom 1081 MOLECULARTESTINGFORVIRUSESIN(XENO)TRANSPLANTATION William D. Rawlinson,Australia 1082 XENOTRANSPLANTATION–AREGULATOR’SPERSPECTIVE stewart sinclair Jessamine,NewZealand

13:30–15:00 Workshop: Biofabrication Part 2: Additive Biofabrication Room 109 for Modelling and Repair of tissue Function 1085 THEPOTENTIALOFCRISPR/CASFORCELLTRANSPLANTAPPLICATIONS- INSIGHTSFROMEDITEDANIMALMODELS Zhou Qi,People’sRepublicofChina 1086 MODELLINGOPTICNEUROPATHIESUSINGIPSCS Raymond c.B. Wong,Australia 1087 BIOSYNTHETICMICRO-TISSUECONSTRUCTSFORMUSCLEREMODELLING Anita Quigley,Australia 1088 BIOFABRICATIONFORREGENERATIVEORTHOPAEDICS Mia Woodruff,Australia THURSDAY

98 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org DETAILED PROGRAM - NOV. 19 IPITA IXA CTS Joint

13:30–15:00 symposium: Organ Degeneration, Mechanisms of Organ Repair/Fibrosis Room 111-112 Chair: Shuji Terai, Japan 1090 HEPATOCYTE,ACELLSOURCEFORLIVERREPOPULATIONANDORGANOGENESIS Kazuo Ohashi,Japan 1091 LUNGREPAIRUSINGAMNIONEPITHELIALCELLS Euan M. Wallace,Australia 1092 BONEMARROWTRANSPLANTATIONFORLIVERREPAIR shuji terai,Japan THURSDAY

November 15–19, 2015 | Melbourne, Australia 99 IPITA • IXA • CTS | www.melbourne2015.org EXHIBIT INFORMATION

AllExhibitorswillbelocatedontheGroundFloorintheMainFoyer1&2.OurExhibitorswouldloveto meetyouduringthefollowingdatesandtimes: n Sunday,November15th 18:00to19:30 n Monday,November16th 08:30to18:30 n Tuesday,November17th 08:30to18:30 n Wednesday,November18th 08:30to18:30

EXHIBITORS Booth # Astellas Australia 5 DON’TJUST Biospherix LtD 8 WALKBY... Hunan Xeno Life technology 1 Mercodia 7 STOP PerkinElmer Life science & technology 4 the transplantation society/iPitA/iXA/cts 6 Vitacyte LLc 2 BY!

100 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SPONSOR DESCRIPTIONS

GOLD LEVEL Astellas

AstellasPharmaInc,basedinTokyo,Japan,isacompanydedicatedtoimprovingthehealthofpeople aroundtheworldthroughtheprovisionofinnovativeandreliablepharmaceuticalproducts.Urology, Oncology,Immunology,Transplantation,andNeuroscienceareourprioritisedtherapeuticareas. “Astellas”expressestheideaof“aspiringandadvancedstars”.Thisexpressionalsocorrespondstothe Japaneseexpression“Asuwoterasu”(shinealightontomorrow). WithourethosofCHANGINGTOMORROW™,Astellasiscommittedtoexploringtherapeuticareasin whichthereisavitalneedfortreatmentsthatimproveandlengthenpatients’lives.Westrivetodevelop therapiesthatarefirst-in-classandbest-in-classtreatmentsthatofferpatientsandtheirdoctors genuinelynewoptionsforimprovingcare. Ourpositionasaleaderinthefieldoftransplantationisaproudaccomplishment.InthefutureAstellas willcontinuetoplayakeyroleinthecareoftransplantpatientsthroughongoingclinicalresearchand newproductdevelopmentbeyondimmunosuppressanttreatments. Visit Astellas Australia at Booth 5

November 15–19, 2015 | Melbourne, Australia 101 IPITA • IXA • CTS | www.melbourne2015.org SPONSOR DESCRIPTIONS

GOLD LEVEL Otsuka Pharmaceutical Factory, inc.

OtsukaPharmaceuticalFactory,Inc.,theoriginatingcompanyofOtsukaGroupwasestablishedin 1921.Webeganmanufacturingintravenoussolutionssuchaslargevolumeparenteralsin1946. “Otsuka’sIntravenousSolutions”arewidelyrecognizedandhighlytrustedasaleadingbrandinJapan andAsia.Wehaveextendedouroperationsintoawidevarietyofareasthroughdevelopmentofnew drugs,innovativepackaging,andintravenousdeliverysystems. Oneoftheareasthatwehaverecentlyenteredisproductdevelopmentoftreatmentfordiabetes patients.Bio-artificialIslet(Diabecell)isanencapsulatedporcineisletcellwhichusesporcineisletcells frompigletsbredunderapathogen-freeenvironmentintendedforhumantransplantation.Diabecellis hopedtosupplementinsulinsecretionthroughtransplantationtodiabetespatient.ItisintendedforType 1diabetespatientswithseverehypoglycemiaandhypoglycemiaunawareness.Diabecellisaimedto reducetheriskforpatientswithhypoglycemiaunawarenessandseverehypoglycemia(coma, lipothymia,spasm,death)thatdonotrespondtoinsulintreatment,andespeciallytoreducetheriskand fearofdead-in-bedsyndrome(deathscausedbyseverehypoglycemiaduringearlymorningornight) WecontinuetodedicateoureffortssothatDiabecellwillbecomeavailableforpatientswithdiabetesto promotetheirhealth. Join Otsuka Pharmaceutical at their symposium November 18th, 11:00–13:30 in Meeting Room 109

102 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SPONSOR DESCRIPTIONS siLVER LEVEL csL

CSLisaglobalspecialtybiopharmaceuticalcompanythataimstoidentify,developandcommercialise important,new,biotherapeuticproductsthathelptosavelivesbypreventingortreatingseriousmedical conditions.CSLiscommittedtosignificantlyinvestinginitsfutureR&Dportfolioandcapabilitiesinthe areasofimmunoglobulins,specialtyproducts,haemophiliaproductsandbreakthroughmedicines. HeadquarteredinMelbournewithsubstantialoperationsintheUnitedStates,Germanyand Switzerland,CSLhasmorethan14,000employeesin30countries.CSLalsohasoneofthelargest plasmacollectionnetworksintheworldandoperatestheonlyinfluenzavaccinemanufacturingfacility intheSouthernHemisphere. Formoreinformationpleasevisitwww.csl.com.au Hunan Xeno Life science Biotechnology

HunanXenoLifeScienceBiotechnologyCompanysetupin2005,locatedinJinzhouNewAreaof Ningxiang,apilotareaforeconomicreformanddevelopmentthatenjoysconvenienttransport connections.OurcompanyiscommittedtoimprovingthelivesofpeoplewithType1diabetesby providingavirtuallyunlimitedsupplyofmedical-gradedonorpigs.Wespecializeincellandgene therapy,pharmaceuticaltechnology,clinicalapplicationandpromotionofmedicaltechnology. Themainmanagementscopeofourcompanyisdevelopingandpreparationofproductsin xenotransplantation.Wehavesetupthebreedingcenterofdesignedpathogenfree(DPF)donorpigin Changsha,whichisthefirstDPFbaseinlinewithWHOstandardinAsia.Basedonthedevelopmentof firstDPFdonorpig(XenoI)inChina,wearecurrentlyusingCRISPR/Cas9genomeeditingtechnology tofurtherdeveloptransgenicDPFdonorpigs,includinggeneticallymodifiedalpha-1,3-Galknockout pigsandothermodificationsincludinghumancomplementandcoagulationregulatoryproteins,and anti-inflammatorymolecules.Inadditionwehavealreadyestablishedanewmodifiedculturesystemfor isletculture,whichcanhighlyimprovetheviabilityandfunctionofβ cells. Weenvisionaworldwithoutdiabetes,aworldwheremonitoringanddailyinsulininjectionsareno longerapartofanyone’slife. Visit Hunan Xeno Life technology at Booth 1

November 15–19, 2015 | Melbourne, Australia 103 IPITA • IXA • CTS | www.melbourne2015.org SPONSOR DESCRIPTIONS

BRONZE LEVEL JDRF

JDRFistheleadingglobalorganizationfundingtype1diabetes(T1D)research.JDRF’sgoalisto progressivelyremovetheimpactofT1Dfrompeople’slivesuntilweachieveaworldwithoutT1D.JDRF collaborateswithawidespectrumofpartnersandistheonlyorganizationwiththescientificresources, policyinfluence,andaworkingplantobettertreat,prevent,andeventuallycureT1D.JDRF-funded researchhasledtomanylandmarkadvancesinT1Dscience.JDRFisnowintheexcitingpositionof takingthatresearchknowledgeandtranslatingitintorealtherapiesthatwillmakelife-changing differencesforthosefacingthedailychallengesofT1D.Currently,JDRFisfundingmorethan50 humanclinicaltrials,severalofwhichareintheadvancedstagesofclinicaltestingneededbeforeFDA approvalscanbesought. JDRF’sinfluenceandleadershipextendsbeyondfundingresearch.Westrategicallypartnerwith industry,governments,foundations,academia,healthcareinsurers,andclinicianstoensurethatJDRF anditspartnersarealignedandworkingtowardacommongoalofaworldwithoutT1D. Please visit www.jdrf.org to learn more about JDRF. Join JDRF at their symposium, November 16th, 12:30-13:30 in Meeting Room 109

104 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org SPONSOR DESCRIPTIONS

BRONZE LEVEL Mesoblast

MesoblastLimitedisagloballeaderinregenerativemedicine.TheCompany’sproprietarytechnology platform,whichisbasedonspecializedcellsknownasmesenchymallineageadultstemcells,orMLCs, hasbeenleveragedtoestablishabroadportfoliooftherapeuticsthatareinmultiplePhase3clinical programsintheUnitedStates.Additionally,Mesoblast’slicensee,JCRPharmaceuticalsCo.Ltd.,has receivedthefirstfullapprovalofanallogeneic,oroff-the-shelf,regenerativemedicineinJapanforits mesenchymalstemcell-basedproduct.Mesoblast’sallogeneicMLCproductcandidatestarget significantlyadvancedstagesofdiseaseswheretherearehighunmetmedicalneeds,including cardiovascularconditions,orthopedicdisorders,immunologicandinflammatorydisorders,and oncology/hematologyconditions. University of Melbourne

TheUniversityofMelbourneisapublic-spiritedinstitutionthatmakesdistinctivecontributionstosociety inresearch,learningandteaching,andbyengagingwithcommunities,corporationsandcultural organisations.OutstandingacademicsareattheheartoftheUniversity’steaching,researchand engagementendeavoursandtheirexceptionalacademicperformancehasplacedtheUniversityof Melbourneamongsttheworld’stopuniversitiesandattheforefrontofhighereducationintheAsia- Pacificregionandbeyond.

November 15–19, 2015 | Melbourne, Australia 105 IPITA • IXA • CTS | www.melbourne2015.org CONTRIBUTORS

the transplantation society would also like to thank our other esteemed contributors who made this event a success:

TSANZ The Transplantation Society of Australia and New Zealand

106 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org EXHIBITOR DESCRIPTIONS Biospherix

StopbytheBioSpherixboothandlearnhowregardlessofproductionprocess,orstageofdevelopment, youcanachievetotalqualitynowwiththeXvivoSystem.Totalqualityrecognizesthatforbestcell potency,cellsneedfull-timeoptimizationofallcriticalcellprocessparameters,duringincubation,and alsoduringhandlingandprocessingupstreamanddownstreamofincubation. Totalqualityrecognizesthatalltypicalnegativesideeffectsofmachinesoncells(particles,heat, vibration,etc.)mustbeneutralizedtomakeautomationcompatiblewithacelloptimizedecosystem. Totalqualityrecognizesthateachbatchmusthaveacompleteend-to-endsecurebatchrecordofall criticalprocessparametersandallcriticalenvironmentalparameters. Totalqualityrecognizesthatunlimitednumbersofbatchesmustbeproduciblesimultaneouslyside-by- side(massivelyparallel)with0%crosscontaminationriskanddispersedgloballywith0%variancerisk andevidencetoproveit.Totalqualityrecognizesthatscalingupandoutmustbeefficientwith0% varianceriskandevidencetoproveit. Totalqualityrecognizesthatvalidationofnewproductioncapacityregardlessofscaleorlocationmust be100%reliableandfast(withindays)andquickandeasytomove,todifferentlocationsgloballyor locallyasneeded(withinweeks). Visit Biospherix at Booth 8

November 15–19, 2015 | Melbourne, Australia 107 IPITA • IXA • CTS | www.melbourne2015.org EXHIBITOR DESCRIPTIONS Mercodia AB

Mercodia-WhenAccuracyMatters. MercodiaABisaSwedishbiotechcompanyfocusingonthedevelopmentofimmunoassaysfor researchwithinthefieldofmetabolicdisorders.Withourstringentqualitysystem,Mercodiaproducts meetthedemandsforrepeatableandreproducibletestresultsfrompharmaceuticalandacademic researchersworldwide.Ourassaysareapplicabletobothanimalandhumanmodelsandareusedfor researchrangingfrombasicscientificstudiestolargepre-clinicalandclinicalphasetrials. World-LeadingSupplier Thecompanywasfoundedin1991andistodayaworld-leadingsupplierofproductstoallmajor internationalmarkets.Morethanninetypercentofourproductionisexportedfromourfacilitiesin Uppsalatoapproximatelyhundreddifferentcountriesaroundtheworld.Mercodiaprovidesa professionalscientificsupportsystembycollaboratinggloballywithcustomersandinstitutions worldwidetodevelopnovelapplicationsforexistingproductsanduniquediagnosticsforemerging markets. Visit Mercodia at Booth 7

108 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org EXHIBITOR DESCRIPTIONS PerkinElmer Life sciences

PerkinElmerLifeSciencesprovidetechnologicalplatformsthatenablehighqualitytranslational researchspanningmoleculetowholeorganismmodels.Visitusatbooth4forascientificdiscussion aboutyourresearchandlearnaboutourinvolvementin: Highcontent/throughputphenotypic/functionalcellularscreening:Goingbeyondbasicimageanalysis parameters,OperettaandOperaPhenixsystemsusesimple,biologicallydrivenanalysistoolstoextract meaningfulsinglecelldatafrom2D,3Dand4Dcellularmodelstypicallyemployedindrug/compound testingcampaignsandpersonalizedmedicineresearchapproaches. QuantitativePathology:Nextgenerationtoolsforstudyingdiseaserelevantbiomarkersignaturesin tissue.Compatiblewithyourexistingimmunohistochemistryapproaches,OpalTSAstainingchemistry &VectraImagingsystemallowsimagingofupto7-plexsimultaneousstainsinfixedtissuesresultingin quantitativecytometrydatawithinthemorphologicalcontextoftraditionalslideimaging.Thisapproach hasledtogreatadvancesinunderstandingcomplexcellulardynamicsintissuedisease microenvironments. NewgenerationELISAreplacementtechnology:Highlysensitive,homogeneousAlphaLISAplatformfor detectionofbiomarkersandcytokines.AlphaLISAisaflexible,no-wash,widedynamicrangeassay formatthatusesverylittlesampleinput(1-5uL),takeshalfthetimeofELISAandiseasytominiaturise andautomate. Visit Perkin Elmer at Booth 4

November 15–19, 2015 | Melbourne, Australia 109 IPITA • IXA • CTS | www.melbourne2015.org EXHIBITOR DESCRIPTIONS Vitacyte

VitaCytemanufacturesabroadrangeofcomprehensivelycharacterized,collagenaseandneutral proteaseenzymesformammaliancellisolationprocedures.Thisrangeincludesanewproductline, definedenrichedcollagenase(DECollagenase),andenablinguserstochoosefrom5differentlow cost,enrichedcollagenase-purifiedneutralproteaseproductsforrecoveringcellsfromtissue.EachDE producthasthesameamountoftotalneutralproteaseactivityperbottlebutdifferentamountsoftotal collagenaseactivity,providingusers’flexibilityinselectingconsistentlymanufacturedproductsforcell isolation.Alternatively,highlypurifiedcollagenaseandneutralproteaseenzymescanbepurchased separatelyandcombinedbasedonusers’needs.VitaCytenowofferspurified,recombinantClostridium histolyticumcollagenase.Recombinantcollagenase,whencombinedwithpurifiedBPProtease(i.e.,a DispaseTMequivalentenzyme),offerscustomersthealternativetousealowercost,animal-originfree enzymemixtureforcellisolation.Recombinantcollagenase-BPProteasemixturesweresuccessfully usedforporcineisletisolation(seeBalamuruganAN,etal.,Abstract#283,thismeeting)andhuman isletisolation[seeTransplantation(2014)98:689-90AbstractD3084,andTweedB,etal.,Abstract# 406thismeeting]. TheintroductionoftheDECollagenaseproductline,recombinantcollagenase,andresults demonstratingtheeffectivenessofBPProteaseforhumanisletisolationreflectsVitaCyte’songoing commitmenttooffercost-effectiveandinnovativesolutionstoaddressuserneedsforbasicandclinical cellisolationprocedures. Visit Vitacyte at Booth 2

110 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org PRESENTER INDEX

Abadpour,Shadab...... 407,885 Campanha-Rodrigues,AnaLucia ...... 855 Abdulreda,MidhatH...... 729 Carmo,TalitaS...... 830 Abicht,Jan-Michael...... 819,820,933 Carrington,EmmaM...... 569 Afelik,Solomon ...... 1069 Casey,John...... 248 Aida,Naohiro...... 740 Chambers,DanielC...... 436 An,Xingxing ...... 298 Chandra,Hem...... 584 Anazawa,Takayuki...... 530 Chang,JaiWon...... 886 AndersonMrs,PatriciaF...... 254 Chen,Pengfei...... 935 Ao,Ziliang ...... 320 Chen,WeiLi...... 642 Appakalai,BalamuruganN...... 100,283,406,597 Chen,Younan...... 607 Arzouni,AhmedA...... 541 Chidgey,AnnP...... 716 Asahi,Yoh ...... 328 Choi,JiYoon ...... 658 Asif,Sana...... 561 Choi,Kimyung...... 920 Austin,AmazonLF...... 542 Chong,James ...... 236 Ayares,David ...... 346,478 Choong,FuiJiun ...... 887 Azimzadeh,AgnesM...... 1056 Choudhary,Pratik...... 133 Bähr,Andrea...... 347 Chung,WenYuan ...... 454,599 Ballav,Chitrabhanu ...... 787 Cimeno,Arielle ...... 1053 Baranovski,BorisM...... 728 Colton,ClarkK...... 535 Barbieux,Charlotte...... 791,904,905 Cooper,DavidK.C...... 570,763,1060 Barkai,Uriel...... 580 Cooper,Matthew ...... 263 Bartlett,StephenT...... 114,264 Coronel,MariaM...... 364 Barton,FrancaB...... 306 Cowan,Peter...... 120,139,758 Bellin,MelenaD...... 102,445,450,451,1006 Cozzi,Emanuele ...... 651,761 Berishvili,Ekaterine...... 362 Crookston,RobJ.R...... 125,132,592 Berman,Andrzej...... 598,861,879 Cross,SarahE...... 308,1042,1048 Berney,Thierry ...... 113,245,1075 Crossan,ClaireL...... 216,645 Berry,Louise...... 127b Currie,PeterD...... 237 Biglarnia,Ali-Reza...... 261 Cwykiel,Joanna ...... 366,379,579 Bochenek,MatthewA...... 538 Dai,Yifan...... 431 Bongoni,AnjanK...... 476,477 Danielson,KirstieK...... 249,741 Bouaoun,Richard...... 537 Davis,MelissaA...... 833 Brady,JamieL...... 282,568 deOliveira,TalitaC...... 408 Brayman,KennethL...... 625,726,735,749 Deans,Robert ...... 315 Brenner,Paolo...... 815 Denner,Joachim ...... 215 Brioudes,Estelle ...... 826,894 Dennison,Ashley...... 1008 Bruni,Antonio...... 403 Dijke,Esme ...... 214 Burdorf,Lars...... 552,934,1050,1057 Djaafar,Souad...... 578 Byrne,GuerardW...... 1010 Docherty,HilaryM...... 587 Byun,Nari...... 577 Docherty,Kevin ...... 777

November 15–19, 2015 | Melbourne, Australia 111 IPITA • IXA • CTS | www.melbourne2015.org PRESENTER INDEX

Dong,Xiaojuan...... 413 Guo,Fei...... 834 Doppenberg,JasonB...... 795,808 Guo,Gang...... 299 Drogemuller,ChristopherJ...... 1038 Guo,Zhiguang...... 325,790,792 Duffy,GarryP...... 609 Han,DuckJong ...... 110 Eby,BrianC...... 335 Hardy,MarkA...... 516 Ekser,Burcin ...... 232,712 HarmonJr.,JamesV...... 207,291,521 Ellis,EwaC...... 715 Hasilo,CraigP...... 322 Esmon,Charles...... 720 Hawthorne,WayneJ...... 206,276,593,802,813 Faleo,Gaetano...... 828 Hayward,JulieA...... 520 Farkas,StefanA...... 227 Heng,TracyS.P...... 565 Federlin,Konrad...... 776 Hering,BernhardJ...... 103,307,509,1020 FernandezDacosta,Raquel...... 380 Higginbotham,LauraB...... 375 Ferrari,Paolo...... 137 Hirata,AparecidaE...... 906 Filippi,Celine...... 845 Holdsworth,Rhonda...... 123 Finger,ErikB...... 260 Horneland,Rune ...... 865 Fisher,Robert...... 317,360,1073 Hosseini-Tabatabaei,Azadeh...... 284 Fisicaro,Nella...... 349 Howe,KathyM...... 129 Forbes,Shareen...... 742 Hu,Min...... 212,566 Frei,AnthonyW...... 536 Huang,Guo...... 402 French,BethM...... 1055,482,483 Huard,Johnny...... 1016 Fridell,JonathanA...... 112,200,202,228, Hurh,Sunghoon ...... 643 265,266,864 Hwa,Albert...... 300 Friend,PeterJ...... 107,225 Irvin,AllisonE...... 612 Fukuoka,Kengo ...... 370 Itescu,Silviu ...... 242 Gala-Lopez,BorisL...... 324 Ito,Masahiro...... 846 Galili,Uri ...... 571,1011 Ito,Taihei...... 866 Galli,Cesare...... 921 Itoh,Takeshi ...... 634,759 Ge,Jingjing ...... 1032 Iwanaga,Yasuhiro...... 594 Geissler,EdwardK...... 240 Iwasaki,Kenta...... 485 GianelloPG,PierreR...... 708,755 Iwase,Hayato...... 231,475,641,814 Golab,KarolinaM...... 825 Jeong,Jee-Heon...... 621 Golson,MariaL...... 778 Jessamine,StewartSinclair ...... 1082 Górski,Lukasz...... 804 Jiang,Kaiyuan...... 529 Goto,Masafumi...... 405 JimenezVera,Elvira...... 1034 Gramignoli,Roberto ...... 235,369,765 Jin,Sang-Man ...... 1036 Grapensparr,LizaE...... 1068 Johnson,PaulR.V...... 794,1025,1037 Grey,ShaneT...... 423,760 1041,1076 Gruessner,AngelikaC...... 106,268,305 Jorns,Carl...... 769 Gruessner,RainerW.G...... 269,332 Juang,Jyuhn-Huarng...... 635 Guell,Marc...... 922 Jung,JooHee ...... 867

112 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org PRESENTER INDEX

Kanak,MazharA...... 323 Lambris,John...... 722 Kandaswamy,Raja...... 105,1078 Laumonier,Thomas...... 831 Kandeel,FouadR...... 222 Laurence,JeromeM...... 330,331,872 Kang,HeeJung...... 275 Lawrence,MichaelC...... 326,468 Kang,Seong-Jun...... 618 LeBerre,LudmillaL...... 556 Kay,ThomasW...... 111 Leal-Lopes,Camila ...... 497 Kearns-Jonker,Mary ...... 1013 Lee,CharlotteA...... 768 Kelly,PatrickJ...... 262,806 Lee,EunMi ...... 615 Kemter,Elisabeth ...... 467 Lee,Kyeong-Min ...... 890 Kenmochi,Takashi ...... 805 Lee,Sanghoon...... 575,766 Kerr-Conte,Julie ...... 884 Lee,Seunghoon...... 854 Khambalia,HusseinA...... 201,267,340 Lee,Whayoung ...... 553,554,706 743,747,868 Lehec,SharonC...... 767 Kieffer,TimothyJ...... 779 Lett,BronD...... 292 Kim,Byung-Joon...... 918 Leventhal,JosephR...... 311 Kim,GeonA...... 923 Lew,AndrewM...... 310 Kim,HwajungH...... 888 Li,Chao...... 788 Kim,HyunJe...... 281 Lima,MariaJoao...... 588 Kim,Jaeyoung...... 412 Lipar,Kvetoslav...... 873 Kim,Jim...... 701 Little,MelissaH...... 435 Kim,Jung-Hee...... 852 Liu,Jingping ...... 290,851 Kim,MeeKum...... 705 Liuwantara,David...... 479 Kim,MinJun...... 622 Loganathan,Gopalakrishnan ...... 465,1040 Kim,YoungJune ...... 924 Loudovaris,Tom...... 301,630,756 Kim,YoungHoon...... 869 Lu,Ying ...... 356 Kirchner,VarvaraA...... 800 Ludwig,Barbara...... 277,511,526 Knight,RichardJ...... 870 Lundgren,Torbjorn ...... 717 Kobayashi,Takaaki...... 138,1022 Ma,Xiaoqian ...... 560,567,908,909,917 Komatsu,Hirotake...... 400,889 Madelon,Natacha ...... 415,462 Kosinová,Lucie...... 610,627 Maeda,Akira ...... 484 Kossugue,PatriciaM...... 829 Maffi,Paola...... 203,205,246,250,733 Koulmanda,Maria ...... 721,1021 MaillardPedracini,Elisa...... 616,631,857,892 Krikke,Christina ...... 803 Mantovani,MarluceC...... 623 Krishnan,Rahul...... 491,499,545,613,628 Marongiu,Fabio ...... 848 Kudva,YogishC...... 871 Martens,GregoryR...... 550 Kuwabara,Rei...... 614 Maruyama,Michihiro...... 601 Kyriazis,PeriklisPanos...... 562 Masterson,Rosemary ...... 135 Laird,ChrisT...... 1051 Matsumoto,Shinichi...... 241,753 Lakey,JonathanR.T...... 490,492,496,498 Matsunari,Hitomi ...... 925 544,581,582,619,629,637,638,907,1035 Mayr,TanjaA.J...... 816,817

November 15–19, 2015 | Melbourne, Australia 113 IPITA • IXA • CTS | www.melbourne2015.org PRESENTER INDEX

McElroy,JoanC...... 127a Parsell,DawnM...... 1054 McGarrigle,JamesJ...... 832 Pattou,Francois ...... 101,252,253,426 McGregor,ChristopherG.A...... 711 Pawitan,JeanneA...... 296 McGuckin,MikeA...... 422 Penko,Daniella ...... 1045 Meier,RaphaelP.H...... 404,414,506,874 Pepper,AndrewR...... 539 Min,Byoung-Hoon...... 647 Pera,Martin...... 441 Min,Catherine...... 893 Petersen,Bjoern...... 350,353,354,927,928 Miwa,Yuko ...... 481 Piemonti,Lorenzo ...... 1005 Miyagawa,Shuji ...... 644,657 PiersonIII,RichardN...... 233,713 Miyanaga,Takashi...... 773 Pilgrim,SuzannaM...... 727 Mohiuddin,MuhammadM...... 230,810,811 Pleass,Henry...... 108,807 Moinuddin,Zia...... 377,875 Posselt,AndrewM...... 425 Montanari,Elisa...... 522 Pozza,Guido...... 775 Mooranian,Armin ...... 583 PuglieseM.D.,Alberto...... 700 Mou,Lisha...... 351 Qi,Zhou...... 1085 Mourad,NizarI...... 279,910 Qian,YiWen...... 416 MyoMin,KayK...... 911 Quigley,Anita...... 1087 Naqvi,RazaA...... 280 Radford,Toni...... 126,131 Naziruddin,Bashoo...... 221,448,455,856,1044 Radke,NancyA...... 128,338 Nikolic-Paterson,David...... 122 Rawlinson,WilliamD...... 1081 O’Connell,PhilipJ...... 247,750,1023 RedfieldIII,RobertR...... 333,801 Obara,Hiromichi ...... 1070 Rickels,MichaelR...... 427 Oberholzer,Jose ...... 600,752,1030 Ricordi,Camillo ...... 251,517,751,896 Ock,SunA ...... 639 Rieben,Robert ...... 551 Odorico,JonS...... 1077,507 Rieblinger,Beate...... 929 Oh,KeonB...... 926 Rilo,HoracioL...... 1007 Ohashi,Kazuo...... 771,1065,1090 Robertson,Paul...... 130 Olack,BarbaraJ...... 632 Rojas-Canales,DarlingM...... 789,912 Olaitan,OyedolamuK...... 876 Rudolph,EhrenN...... 730 Ong,SzeHwee ...... 363 Sackett,SaraD...... 461 Ono,Hitoshi...... 525 Safley,SusanA...... 495,754 Oshima,Minoru...... 877 Sahara,Hisashi...... 1052,368 Ostaszewska,Agata...... 878 Sakata,Naoaki...... 208 Otsuki,Kazunori...... 745 Salama,Apolline...... 348,555 Pan,Zhiqiang...... 411 Salvaris,Evelyn...... 352 Papas,KlearchosK...... 303,1049 Sandrin,MauroS ...... 121 Paraskevas,Steven ...... 1026 Sapozhnikov,Lena ...... 585 Park,Chung-Gyu...... 707 Sato,Naoya...... 528 Park,Hyojun...... 409,653,654,655 Saudek,Frantisek ...... 204,220,336,595,596 Park,Kwangwook...... 636 Scharp,DavidW...... 1047

114 Joint congress of the iPitA, iXA and cts IPITA • IXA • CTS | www.melbourne2015.org PRESENTER INDEX

Schive,SimenW...... 1039 Tector,AlfredJoseph...... 440 Schmid,Janine...... 897 Tena,Aseda...... 376 Scholz,Hanne...... 512 Terai,Shuji...... 367,1092 Schubert,Undine...... 523 Teramura,Yuji...... 493 Schuetz,ChristianS...... 508,919 Terra,LetíciaF...... 859 Scobie,Linda...... 1080 Thomas,HelenE...... 421 ScottIII,WilliamE...... 604,605 Tian,Bole ...... 843 Sfriso,Riccardo...... 480 Timpson,Alan...... 1046 Shen,Di...... 626 Tönjes,RalfR...... 218 Shi,Meimei...... 295 Tremmel,DanielM...... 624 Shigeta,Takanobu...... 770 Trounson,AlanO...... 1017 Shimizu,Hirofumi ...... 543 Trzonkowski,Piotr ...... 702 Shimoda,Masayuki...... 590,640 Tsai,Shiao-Wen ...... 840 Shin,DuYeon...... 355,466,649,913 Tu,Ching-Fu...... 931 Shin,Jun-Seop...... 648 Ullsten,SaraM...... 378 Sigrist,Séverine ...... 898,899 Uluer,MehmetC...... 1059 Silveira,PabloA...... 564 Uva,PabloD...... 339,744 Simpson,AnnM...... 361 vanApeldoorn,AartA...... 464,1067,1072 Singer,AndrewL...... 880 Vantyghem,Marie-Christine ...... 746 Singh,Amar...... 731,732 Vosough,Massoud...... 589 Singh,Avneesh...... 812,1058 Waibel,Michaela ...... 915 Sivanathan,KishaNandini ...... 293 Wailemann,RosangelaA.M...... 860 Smink,AlexandraM...... 900 Wallace,EuanM...... 1091 Smith,Kate...... 470,827,901 Wallace,Gordon...... 442,1000 Snyder,EvanY...... 316,1015 Wang,Hongjun...... 327,453 Sollinger,HansW...... 515 Wang,Ling-jia...... 1043 Spadella,CésarTadeu...... 608 Wang,Shusen...... 463 Stabler,CherieL...... 302,494,611 Wang,Xin...... 294,576 Stead,SebastianO...... 563,620 Wang,Yong ...... 321,401,591,786,916 Steffen,Anja ...... 633,656,914 Watanabe,Masaaki...... 849 Stevens,Sean...... 430 Weaver,JessicaD...... 500 Steyn,LeahV...... 1066,1071 Weegman,BradleyP...... 586,748 Stock,PeterG...... 226,762 Wei,Hongjiang ...... 936 Stranks,JessicaL...... 881 West,LoriJ...... 213,1012 Sutherland,DavidE.R...... 449,505 Wilhelm,JoshuaJ...... 446,606 Tai,Hao-Chih...... 930 Withers,BarbaraP...... 365 Takeuchi,Yasuhiro ...... 217 Witkowski,Piotr...... 255,337,447,602,603 Takita,Morihito ...... 209 Wolf,Eckhard ...... 757 Tan,Yixiong...... 650 Wong,RaymondC.B...... 1086 Tang,Qizhi ...... 703 Woodruff,Mia...... 1088

November 15–19, 2015 | Melbourne, Australia 115 IPITA • IXA • CTS | www.melbourne2015.org PRESENTER INDEX

Wszoła,Michał...... 452,469,1033 Yamada,Kazuhiko...... 710 Yan,Ji-Jing...... 278 Yang,HaeKyung...... 617 Yang,Jaeseok...... 136 Yang,Luhan ...... 345 Yang,Tien-Shuh...... 932 Yeh,ChunChieh ...... 809 Yi,Shounan...... 312,646 Yiannoullou,Petros ...... 334,862 Yohichi,Yasunami ...... 785 Yoshida,Satoru ...... 772,850 Yoshimatsu,Gumpei ...... 527,902 Yuan,Yujia...... 297 Yun,IkJin...... 818 Zammit,NathanW...... 510,524 Zhang,Mei ...... 895 Zhang,Mingyou...... 410 Zhang,Wensheng ...... 725 Zhang,Zhengkun ...... 903 Zhou,KianeJ...... 882

116 Joint congress of the iPitA, iXA and cts www.tts.org 2016 2017 Meetings NGO in official relations with WHO at a Glance

TID 2016 HONG KONG August 18, 2016

IPTA 2017 BARCELONA May 27-30, 2017

IRTA 2017 NEW YORK June 28–July 1, 2017

IPITA 2017 OXFORD June 20–23, 2017

ISODP 2017 GENEVA September 6-9, 2017

IXA 2017 BALTIMORE September 20-23, 2017

CTRMS 2017 HALIFAX September 26-29, 2017 Joint Meeting with CST Canadian Society of Transplantation www.tts2016.org