Huang Zongxi's and John Locke's Rhetoric Toward Modernity Abstract
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Suppression of DNA-Damage Checkpoint Signaling by Rsk-Mediated Phosphorylation of Mre11
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11 Chen Chen, Liguo Zhang, Nai-Jia Huang, Bofu Huang, and Sally Kornbluth1 Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710 Edited by Tony Hunter, The Salk Institute for Biological Studies, La Jolla, CA, and approved November 12, 2013 (received for review April 9, 2013) Ataxia telangiectasia mutant (ATM) is an S/T-Q–directed kinase A hallmark of cancer cells is their ability to override cell-cycle that is critical for the cellular response to double-stranded breaks checkpoints, including the DSB checkpoint, which arrests the cell (DSBs) in DNA. Following DNA damage, ATM is activated and cycle to allow adequate time for damage repair. Previous studies recruited by the MRN protein complex [meiotic recombination 11 have implicated the MAPK pathway in inhibition of DNA-dam- (Mre11)/DNA repair protein Rad50/Nijmegen breakage syndrome age signaling: PKC suppresses DSB-induced G2/M checkpoint 1 proteins] to sites of DNA damage where ATM phosphorylates signaling following ionizing radiation via activation of ERK1/2 multiple substrates to trigger cell-cycle arrest. In cancer cells, this (22); activation of RAF kinase, leading to activation of MEK/ regulation may be faulty, and cell division may proceed even in ERK/Rsk, also can suppress G2/M checkpoint signaling (23). the presence of damaged DNA. We show here that the ribosomal Given its prominent role in multiple cancers, the MAPK s6 kinase (Rsk), often elevated in cancers, can suppress DSB-induced pathway is an attractive therapeutic target. Indeed, treatment of melanoma using the RAF inhibitor vemurafenib has shown some ATM activation in both Xenopus egg extracts and human tumor cell clinical success, as has treatment of nonsmall cell lung carcinoma lines. -
The Status of Cosmic Principle (Li) in Neo-Confucian Metaphysics
jeeloo liu THE STATUS OF COSMIC PRINCIPLE (LI) IN NEO-CONFUCIAN METAPHYSICS Introduction In this article, I attempt to make use of Western metaphysical notions to explicate the cosmological variances in Chinese philosophical thinking, with specific reference to the debates among the Neo- Confucian thinkers. While I do not presume and argue that Chinese philosophers dealt with the same Western issues, I do believe that a comparative study of this nature can point to a new direction of think- ing concerning metaphysical pondering in Neo-Confucianism. This article is divided into three parts. In Part I, I employ Robert Nozick’s notion of natural cosmic state to analyze the fundamental difference between the Confucian and Daoist cosmologies. Even though this notion of natural cosmic state has no comparable match in Chinese philosophy, it may serve as an analytic and explanatory device for our comparative study of Chinese cosmology. In Part II, I employ Nicholas Rescher’s distinction between “laws of nature” and “laws for nature” to analyze the debate on the status of cosmic prin- ciple (li)a between Zhou Dunyib and Zhu Xic on the one hand, and Zhang Zaid and Wang Fuzhie on the other.1 In Part III, I employ the notion of supervenience,as defined by Jaegwon Kim,to argue that in the debate on the status of cosmic principle, it is Zhang Zai and Wang Fuzhi’s view that better preserves the causal relevance of cosmic principle in a physicalistic universe.2 In light of the three notions borrowed from contemporary Western metaphysics, I hope to offer an analytic reconstruction of the age-old debate on the status of cosmic principle (li). -
Chinese Philosophy
CHINESE PHILOSOPHY Vatican Relations: Problems of Conflicting Authority, 1976–1986 EARLY HISTORY (Cambridge 1992). J. LEUNG, Wenhua Jidutu: Xianxiang yu lunz- heng (Cultural Christian: Phenomenon and Argument) (Hong Shang Dynasty (c.1600–c.1045 B.C.). Chinese Kong 1997). K. C. LIU, ed. American Missionaries in China: Papers philosophical thought took definite shape during the reign from Harvard Seminars (Cambridge 1966). Lutheran World Feder- of the Shang dynasty in Bronze Age China. During this ation/Pro Mundi Vita. Christianity and the New China (South Pasa- period, the primeval forms of ancestor veneration in Neo- dena 1976). L. T. LYALL, New Spring in China? (London 1979). J. G. LUTZ, ed. Christian Missions in China: Evangelist of What? lithic Chinese cultures had evolved to relatively sophisti- (Boston 1965). D. E. MACINNIS, Religion in China Today: Policy cated rituals that the Shang ruling house offered to their and Practice (Maryknoll, NY 1989). D. MACINNIS and X. A. ZHENG, ancestors and to Shangdi, the supreme deity who was a Religion under Socialism in China (Armonk, NY 1991). R. MAD- deified ancestor and progenitor of the Shang ruling fami- SEN, China Catholics: Tragedy and Hope in an Emerging Civil So- ciety (Berkeley 1998). R. MALEK and M. PLATE Chinas Katholiken ly. A class of shamans emerged, tasked with divination suchen neue (Freiburg 1987). Missiones Catholicae cura S. Con- and astrology using oracle bones for the benefit of the rul- gregationis de Propaganda Fide descriptae statistica (Rome 1901, ing class. Archaeological excavations have uncovered 1907, 1922, 1927). J. METZLER, ed. Sacrae Congregationis de Pro- elaborate bronze sacrificial vessels and other parapherna- paganda Fide Memoria Rerum, 1622–1972 (Rome 1976). -
Political Thoughtyuri Pinespolitical Thought
13 POLITICAL THOUGHTYURI PINESPOLITICAL THOUGHT Yuri Pines* The three centuries that preceded the establishment of the Chinese empire in 221 bce were an age of exceptional intellectual flourishing. No other period in the history of Chinese thought can rival these centuries in creativity, boldness, ideological diversity, and long-term impact. Val- ues, perceptions, and ideals shaped amid intense intellectual debates before the imperial unifi- cation contributed decisively to the formation of the political, social, and ethical orientations that we identify today with traditional Chinese culture. More broadly, the ideas of rival thinkers formed an ideological framework within which the Chinese empire functioned from its incep- tion until its very last decades. These ideas stand at the focus of the present chapter. The centuries under discussion are often dubbed the age of the “Hundred Schools of Thought.” The school designations were developed primarily by the Han (206/202 bce–220 ce) literati (Smith 2003; Csikszentmihalyi and Nylan 2003) as a classificatory device for the variety of pre-imperial texts. This classification, even if belated, may be heuristically convenient insofar as it groups the texts according to their distinct ideological emphases, distinct vocabulary, and distinct argumentative practices. For instance, followers of Confucius (551–479 bce) and Mozi 墨子 (ca. 460–390 bce) were prone to prioritize morality over pure political considerations, in distinction from those thinkers who are – quite confusingly (Goldin 2011a) – dubbed Legalists (fa jia 法家). Confucians (Ru 儒) and Legalists also differed markedly with regard to the nature of elite belonging (see later). This said, it is fairly misleading to imagine “schools” as coherent ideological camps, as was often done through the twentieth century and beyond. -
The Significance and Inheritance of Huang Di Culture
ISSN 1799-2591 Theory and Practice in Language Studies, Vol. 8, No. 12, pp. 1698-1703, December 2018 DOI: http://dx.doi.org/10.17507/tpls.0812.17 The Significance and Inheritance of Huang Di Culture Donghui Chen Henan Academy of Social Sciences, Zhengzhou, Henan, China Abstract—Huang Di culture is an important source of Chinese culture. It is not mechanical, still and solidified but melting, extensible, creative, pioneering and vigorous. It is the root of Chinese culture and a cultural system that keeps pace with the times. Its influence is enduring and universal. It has rich connotations including the “Root” Culture, the “Harmony” Culture, the “Golden Mean” Culture, the “Governance” Culture. All these have a great significance for the times and the realization of the Great Chinese Dream, therefore, it is necessary to combine the inheritance of Huang Di culture with its innovation, constantly absorb the fresh blood of the times with a confident, open and creative attitude, give Huang Di culture a rich connotation of the times, tap the factors in Huang Di culture that fit the development of the modern times to advance the progress of the country and society, and make Huang Di culture still full of vitality in the contemporary era. Index Terms—Huang Di, Huang Di culture, Chinese culture I. INTRODUCTION Huang Di, being considered the ancestor of all Han Chinese in Chinese mythology, is a legendary emperor and cultural hero. His victory in the war against Emperor Chi You is viewed as the establishment of the Han Chinese nationality. He has made great many accomplishments in agriculture, medicine, arithmetic, calendar, Chinese characters and arts, among which, his invention of the principles of Traditional Chinese medicine, Huang Di Nei Jing, has been seen as one of the greatest contributions to Chinese medicine. -
Democracy in Confucianism Sor-Hoon TAN Singapore Management University, [email protected] DOI
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Institutional Knowledge at Singapore Management University Singapore Management University Institutional Knowledge at Singapore Management University Research Collection School of Social Sciences School of Social Sciences 5-2012 Democracy in Confucianism Sor-hoon TAN Singapore Management University, [email protected] DOI: https://doi.org/10.1111/j.1747-9991.2012.00481.x Follow this and additional works at: https://ink.library.smu.edu.sg/soss_research Part of the Arts and Humanities Commons Citation TAN, Sor-hoon.(2012). Democracy in Confucianism. Philosophy Compass, 7(5), 293-303. Available at: https://ink.library.smu.edu.sg/soss_research/2546 This Journal Article is brought to you for free and open access by the School of Social Sciences at Institutional Knowledge at Singapore Management University. It has been accepted for inclusion in Research Collection School of Social Sciences by an authorized administrator of Institutional Knowledge at Singapore Management University. For more information, please email [email protected]. Published in Philosophy Compass, Vol. 7, Issue 5, May 2012, page 292-303Philosophy Compass 7/5 (2012): 293–303, 10.1111/j.1747-9991.2012.00481.x Democracy in Confucianism Sor-hoon Tan* National University of Singapore Abstract Confucianism’s long historical association with despotism has cast doubts on its compatibility with democracy, and raise questions about its relevance in contemporary societies increasingly domi- nated by democratic aspirations. ‘‘Confucian democracy’’ has been described as a ‘‘contradiction in terms’’ and Asian politicians have appropriated Confucianism to justify resistance to liberaliza- tion and democratization. -
Neo-Confucianism: Metaphysics, Mind, and Morality
Neo-Confucianism: Metaphysics, Mind, and Morality BOOK PROSPECTUS JeeLoo Liu CONTENTS: SUMMARY OF CHAPTERS Since these selected Neo-Confucians had similar philosophical concerns and their various philosophical positions were based on largely the same Confucian classics, the best way to capture their philosophical variances is to present their views thematically rather than chronologically. The structure of this book lays out the metaphysical foundations for Neo-Confucian theories of mind and morality. The major common themes in Neo- Confucianism include: 1) The relationship between the two constituents of the universe—cosmic principle (li) and cosmic force (qi); 2) The debate on whether human nature, or human mind, is the exemplification of this cosmic principle; 3) The analysis of the roots of human good and evil as a way to answer the question of what makes human morality possible. This book is divided into three parts, which deal with these three issues as they evolved from one Neo-Confucian philosopher to the next. The eight philosophers’ views are presented in three segments, as this arrangement best captures both the focus of their disagreements and the continuity of the philosophical development of Neo-Confucianism. Part I. Neo-Confucian Metaphysics: from Cosmology to Ontology Neo-Confucians were generally concerned with establishing a moralistic cosmology, or we can say what they developed was a form of moral metaphysics. In their view, there is a higher order governing the cosmos, which they call ‘heavenly principle’, and this higher order has many moral attributes. At the same time, Neo-Confucians also embraced the Chinese philosophical tradition (founded in Yijing) of positing a cosmic force (qi) as the material/physical foundation of the universe. -
The Later Han Empire (25-220CE) & Its Northwestern Frontier
University of Pennsylvania ScholarlyCommons Publicly Accessible Penn Dissertations 2012 Dynamics of Disintegration: The Later Han Empire (25-220CE) & Its Northwestern Frontier Wai Kit Wicky Tse University of Pennsylvania, [email protected] Follow this and additional works at: https://repository.upenn.edu/edissertations Part of the Asian History Commons, Asian Studies Commons, and the Military History Commons Recommended Citation Tse, Wai Kit Wicky, "Dynamics of Disintegration: The Later Han Empire (25-220CE) & Its Northwestern Frontier" (2012). Publicly Accessible Penn Dissertations. 589. https://repository.upenn.edu/edissertations/589 This paper is posted at ScholarlyCommons. https://repository.upenn.edu/edissertations/589 For more information, please contact [email protected]. Dynamics of Disintegration: The Later Han Empire (25-220CE) & Its Northwestern Frontier Abstract As a frontier region of the Qin-Han (221BCE-220CE) empire, the northwest was a new territory to the Chinese realm. Until the Later Han (25-220CE) times, some portions of the northwestern region had only been part of imperial soil for one hundred years. Its coalescence into the Chinese empire was a product of long-term expansion and conquest, which arguably defined the egionr 's military nature. Furthermore, in the harsh natural environment of the region, only tough people could survive, and unsurprisingly, the region fostered vigorous warriors. Mixed culture and multi-ethnicity featured prominently in this highly militarized frontier society, which contrasted sharply with the imperial center that promoted unified cultural values and stood in the way of a greater degree of transregional integration. As this project shows, it was the northwesterners who went through a process of political peripheralization during the Later Han times played a harbinger role of the disintegration of the empire and eventually led to the breakdown of the early imperial system in Chinese history. -
Jade Huang and Chinese Culture Identity: Focus on the Myth of “Huang of Xiahoushi”
Journal of Literature and Art Studies, June 2016, Vol. 6, No. 6, 603-618 doi: 10.17265/2159-5836/2016.06.003 D DAVID PUBLISHING Jade Huang and Chinese Culture Identity: Focus on the Myth of “Huang of Xiahoushi” TANG Qi-cui, WU Yu-wei Shanghai Jiao Tong University, Shanghai, China This paper focus on the myth of “Huang of Xiahoushi” (夏后氏之璜), focusing on the distribution of Jade Huang (玉璜) since the early neolithic and its process of pluralistic integration. The paper explores the story of ethnic group, cultural identification and the significance of Jade Huang in the discourse construction of etiquette civilization behind the mythic narrative based on multi-evidence method and the local meaning of literature in ancient Chinese context. Keywords: Jade Huang, Huang of Xiahoushi, unified diversity, Chinese identity, etiquette civilization, multi-evidence method Introduction Modern archeological relics including potteries, jades and bronzes bring back the lost history; the process of how Chinese unified diversity took shape in general and the great tradition of jade culture in eight thousand in particular. The handed-down documents echo each other at a distance provide solid evidences for the origin of civilization of rite and music and the core values based on jade belief. Jade Huang is an important one of it. It is illuminated by numerous records about Jade Huang in ancient literature, as well as a large number of archaeology findings past 7,000 years. The paper seeks to focus on the following questions: what is the function of Jade Huang in historic and prehistoric period? Moreover, what is the function of “Huang of Xiahoushi”, which belonged to emperor and symbolized special power in historic documents and myths and legends in ancient china? Jade Huang: Etiquette and Literature Jade Huang (Yu Huang, Semi-circular/annular Jade Pendant) is a type of jade artifact which is seemed to be remotely related to etiquette and literature. -
Dai Zhen's Ethical Philosophy of the Human Being
Dai Zhen’s Ethical Philosophy of the Human Being By Ho Young Lee Thesis submitted for the Degree of Doctor of Philosophy in the Department of the Study of Religions School of Oriental and African Studies University of London 2006 ProQuest Number: 10672979 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest ProQuest 10672979 Published by ProQuest LLC(2017). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code Microform Edition © ProQuest LLC. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 4 8 1 0 6 - 1346 Abstract The moral philosophy of Dai Zhen can be summarised as “fulfil desires and express feelings”. Because he believed that life is the most cherished thing for all man and thing, he maintains that “whatever issues from desire is always for the sake of life and nurture.” He also claimed that “caring for oneself, and extending this care to those close to oneself, are both aspects of humanity" He set up a strong monastic moral philosophy based on individual human desire and feeling. As the title ‘Dai Zhen’s philosophy of the ethical human being’ demonstrate, human physical body and activities of life is ethical base of philosophy of Dai Zhen. -
Politics, Classicism, and Medicine During the Eighteenth Century 十八世紀在德川日本 "頌華者" 和 "貶華者" 的 問題 – 以中醫及漢方為主
East Asian Science, Technology and Society: an International Journal DOI 10.1007/s12280-008-9042-9 Sinophiles and Sinophobes in Tokugawa Japan: Politics, Classicism, and Medicine During the Eighteenth Century 十八世紀在德川日本 "頌華者" 和 "貶華者" 的 問題 – 以中醫及漢方為主 Benjamin A. Elman Received: 12 May 2008 /Accepted: 12 May 2008 # National Science Council, Taiwan 2008 Abstract This article first reviews the political, economic, and cultural context within which Japanese during the Tokugawa era (1600–1866) mastered Kanbun 漢 文 as their elite lingua franca. Sino-Japanese cultural exchanges were based on prestigious classical Chinese texts imported from Ming (1368–1644) and Qing (1644–1911) China via the controlled Ningbo-Nagasaki trade and Kanbun texts sent in the other direction, from Japan back to China. The role of Japanese Kanbun teachers in presenting language textbooks for instruction and the larger Japanese adaptation of Chinese studies in the eighteenth century is then contextualized within a new, socio-cultural framework to understand the local, regional, and urban role of the Confucian teacher–scholar in a rapidly changing Tokugawa society. The concluding part of the article is based on new research using rare Kanbun medical materials in the Fujikawa Bunko 富士川文庫 at Kyoto University, which show how some increasingly iconoclastic Japanese scholar–physicians (known as the Goiha 古醫派) appropriated the late Ming and early Qing revival of interest in ancient This article is dedicated to Nathan Sivin for his contributions to the History of Science and Medicine in China. Unfortunately, I was unable to present it at the Johns Hopkins University sessions in July 2008 honoring Professor Sivin or include it in the forthcoming Asia Major festschrift in his honor. -
LL4375 / LL5375 / LL6375 Traditional Chinese Legal Thought This Course
LL4375 / LL5375 / LL6375 Traditional Chinese Legal Thought This course is an introduction to the major themes and issues in traditional Chinese legal thought. A basic premise and argument of this course is that Chinese legal thought should not, and indeed cannot, be studied in a vacuum. As such, we will also make reference to Chinese political and moral philosophy, as well as historical context. We will focus our attention on the close reading and analysis of selected works by various philosophers and various philosophical schools, including Confucius and later Confucian thinkers (including, but not limited to, Mencius, Xunzi, and Dong Zhongshu), the Legalists, and the Daoists. Attention will also be placed on understanding these thinkers and philosophical schools in historical context and gaining an understanding of how law was applied in premodern Chinese society. No prior knowledge of Chinese history or Chinese philosophy is assumed or required. All required readings are in English. At the end of the course participants should be able to: 1. Demonstrate awareness and understanding of the important norms, themes, principles, and concerns of traditional Chinese legal thought. 2. Describe and explain the key ideas of Confucian (including pre-Qin Confucianism, Han dynasty Confucianism, Tang dynasty Confucianism, and Neo-Confucianism), Daoist, and Legalist legal and political thought. 3. Develop an awareness and understanding of how traditional Chinese legal thought is enmeshed in traditional Chinese moral and political thought. 4. Develop an awareness and understanding of how ideas and norms in traditional Chinese legal thought were applied (or not applied) in premodern Chinese jurisprudence. 5. Develop an awareness and understanding of how traditional Chinese legal thought compares and contrasts to Western legal thought.