H2AFX Monoclonal Antibody, Clone 938CT5.1.1

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H2AFX Monoclonal Antibody, Clone 938CT5.1.1

H2AFX monoclonal antibody, clone Gene Summary: Histones are basic nuclear proteins 938CT5.1.1 that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of Catalog Number: MAB12332 each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of Regulatory Status: For research use only (RUO) DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA Product Description: Mouse monoclonal antibody between nucleosomes and functions in the compaction raised against synthetic peptide of human H2AFX. of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and Clone Name: 938CT5.1.1 generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA Immunogen: A synthetic peptide (conjugated with KLH) addition motif. [provided by RefSeq] corresponding to amino acids 115-143 at C-terminus region of human H2AFX. Host: Mouse Reactivity: Human Applications: IHC-P, WB-Ce (See our web site product page for detailed applications information) Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols Form: Liquid Purification: Protein G purification Isotype: IgG1 Recommend Usage: Immunohistochemistry (1:25) Western Blot (1:1000) The optimal working dilution should be determined by the end user. Storage Buffer: In PBS (0.09% sodium azide) Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 3014 Gene Symbol: H2AFX Gene Alias: H2A.X, H2A/X, H2AX Page 1/1 Powered by TCPDF (www.tcpdf.org).

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NBN Gene Analysis and It's Impact on Breast Cancer
Journal of Medical Systems (2019) 43: 270 https://doi.org/10.1007/s10916-019-1328-z IMAGE & SIGNAL PROCESSING NBN Gene Analysis and it’s Impact on Breast Cancer P. Nithya1 & A. ChandraSekar1 Received: 8 March 2019 /Accepted: 7 May 2019 /Published online: 5 July 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019 Abstract Single Nucleotide Polymorphism (SNP) researches have become essential in finding out the congenital relationship of structural deviations with quantitative traits, heritable diseases and physical responsiveness to different medicines. NBN is a protein coding gene (Breast Cancer); Nibrin is used to fix and rebuild the body from damages caused because of strand breaks (both singular and double) associated with protein nibrin. NBN gene was retrieved from dbSNP/NCBI database and investigated using computational SNP analysis tools. The encrypted region in SNPs (exonal SNPs) were analyzed using software tools, SIFT, Provean, Polyphen, INPS, SNAP and Phd-SNP. The 3’ends of SNPs in un-translated region were also investigated to determine the impact of binding. The association of NBN gene polymorphism leads to several diseases was studied. Four SNPs were predicted to be highly damaged in coding regions which are responsible for the diseases such as, Aplastic Anemia, Nijmegan breakage syndrome, Microsephaly normal intelligence, immune deficiency and hereditary cancer predisposing syndrome (clivar). The present study will be helpful in finding the suitable drugs in future for various diseases especially for breast cancer. Keywords NBN . Single nucleotide polymorphism . Double strand breaks . nsSNP . Associated diseases Introduction NBN has a more complex structure due to its interaction with large proteins formed from the ATM gene which is NBN (Nibrin) is a protein coding gene, it is also known as highly essential in identifying damaged strands of DNA NBS1, Cell cycle regulatory Protein P95, is situated on and facilitating their repair [1].
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