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[email protected] Product Information Anti-ATM antibody produced in chicken, affinity isolated antibody Catalog Number GW21178 Formerly listed as GenWay Catalog Number 15-288-21178, Serine-protein kinase ATM Antibody. – Storage Temperature Store at 20 °C The product is a clear, colorless solution in phosphate buffered saline, pH 7.2, containing 0.02% sodium azide. Synonyms: Ataxia telangiectasia mutated protein isoform 1, EC 2.7.11.1; Ataxia telangiectasia mutated; A-T, mutated Species Reactivity: Human, mouse Product Description Tested Applications: WB Serine/threonine protein kinase which activates checkpoint Recommended Dilutions: Recommended starting dilution signaling upon double strand breaks (DSBs). apoptosis and for Western blot analysis is 1:500, for tissue or cell staining genotoxic stresses such as ionizing ultraviolet A light (UVA). 1:200. thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [S/T-Q]. Phosphorylates Ser- Note: Optimal concentrations and conditions for each 139 of histone variant H2AX/H2AFX at double strand breaks application should be determined by the user. (DSBs). thereby regulating DNA damage response mecha- Precautions and Disclaimer nism. Also involved in signal transduction and cell cycle This product is for R&D use only, not for drug, household, or control. May function as a tumor suppressor. Necessary for other uses. Due to the sodium azide content a material activation of ABL1 and SAPK. Phosphorylates p53/TP53, safety data sheet (MSDS) for this product has been sent to FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, the attention of the safety officer of your institution.