List of Vital Essential and Necessary Drugs and Medical Sundries For
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S Values in Accordance with Soczewiński-Wachtmeisters Equation
S values in accordance with Soczewiński-Wachtmeisters equation S value from Antiparasitic drugs: Soczewiński’s Metronidazole Ornidazole Secnidazole Tinidazole Equation* S(m) 1.614 2.161 1.921 1.911 S(a) 1.634 2.159 1.887 1.923 S value from Antihypertensive drugs: Soczewiński’s Nilvadipine Felodipine Isradipine Lacidipine equation 4.129 4.597 3.741 5.349 S(m) S(a) 5.330 4.841 4.715 5.690 S value from Non-steroidal anti-inflammatory drugs (NSAIDs): Soczewiński’s Mefenamic Indomethacin Nabumetone Phenylbutazone Carprofen Ketoprofen Flurbiprofen equation acid 2.879 2.773 3.456 2.682 2.854 2.139 2.568 S(m) 3.317 3.442 3.910 2.404 3.394 1.968 2.010 S(a) *where: S(m) – S is the slope of the regression curie in accordance with Soczewiński-Wachtmeisters equation using methanol-water mobile phase S(a) – S is the slope of the regression curie in accordance with Soczewiński-Wachtmeisters equation using acetone-water mobile phase First group of drugs (antiparasitic drugs) 1. Metronidazole (2-Methyl-5-nitroimidazole-1-ethanol) 2. Ornidazole (1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole) 3. Secnidazole (1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2ol, 1-(2Hydroxypropyl)-2-methyl-5- nitroimidazole) 4. Tinidazole (1-[2-(Ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole) Second group of drugs (antihypertensive drugs) 1. Nilvadipine (2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3- methyl 5-(1-methylethyl) ester, 5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m- nitrophenyl)-3,5-pyridinedicarboxylate, FK-235, FR-34235, Isopropyl 6-cyano-5-methoxycarbonyl-2- methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate) 2. -
Product List March 2019 - Page 1 of 53
Wessex has been sourcing and supplying active substances to medicine manufacturers since its incorporation in 1994. We supply from known, trusted partners working to full cGMP and with full regulatory support. Please contact us for details of the following products. Product CAS No. ( R)-2-Methyl-CBS-oxazaborolidine 112022-83-0 (-) (1R) Menthyl Chloroformate 14602-86-9 (+)-Sotalol Hydrochloride 959-24-0 (2R)-2-[(4-Ethyl-2, 3-dioxopiperazinyl) carbonylamino]-2-phenylacetic 63422-71-9 acid (2R)-2-[(4-Ethyl-2-3-dioxopiperazinyl) carbonylamino]-2-(4- 62893-24-7 hydroxyphenyl) acetic acid (r)-(+)-α-Lipoic Acid 1200-22-2 (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 207557-35-5 1,1'-Carbonyl diimidazole 530-62-1 1,3-Cyclohexanedione 504-02-9 1-[2-amino-1-(4-methoxyphenyl) ethyl] cyclohexanol acetate 839705-03-2 1-[2-Amino-1-(4-methoxyphenyl) ethyl] cyclohexanol Hydrochloride 130198-05-9 1-[Cyano-(4-methoxyphenyl) methyl] cyclohexanol 93413-76-4 1-Chloroethyl-4-nitrophenyl carbonate 101623-69-2 2-(2-Aminothiazol-4-yl) acetic acid Hydrochloride 66659-20-9 2-(4-Nitrophenyl)ethanamine Hydrochloride 29968-78-3 2,4 Dichlorobenzyl Alcohol (2,4 DCBA) 1777-82-8 2,6-Dichlorophenol 87-65-0 2.6 Diamino Pyridine 136-40-3 2-Aminoheptane Sulfate 6411-75-2 2-Ethylhexanoyl Chloride 760-67-8 2-Ethylhexyl Chloroformate 24468-13-1 2-Isopropyl-4-(N-methylaminomethyl) thiazole Hydrochloride 908591-25-3 4,4,4-Trifluoro-1-(4-methylphenyl)-1,3-butane dione 720-94-5 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine Hydrochloride 28783-41-7 4-Chloro-N-methyl-piperidine 5570-77-4 -
Effect of Lacidipine and Nifedipine GITS on Platelet Function in Patients with Essential Hypertension
Journal of Human Hypertension (2000) 14, Suppl 1, S91–S95 2000 Macmillan Publishers Ltd All rights reserved 0950-9240/00 $15.00 www.nature.com/jhh Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension MC Armas-Padilla1, MJ Armas-Herna´ndez1, R Herna´ndez-Herna´ndez1, M Velasco2, B Pacheco1, AR Carvajal1 and A Castillo-Moreno1 1Clinical Pharmacology Unit, School of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela; 2Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas, Venezuela With the aim of evaluating the effects on blood pressure, Both drugs reduced systolic and diastolic blood press- platelet function and insulin sensitivity of the dihydro- ure at the same level, however there were observable piridines lacidipine and nifedipine GITS, a parallel dou- differences in the rate of reduction. The nifedipine GITS ble-blind study was carried out in a group of 20 patients reduced supine systolic blood pressure by 25 mm Hg in with mild to moderate essential hypertension. They the first week, while the lacidipine did so by 11 mm Hg. received a placebo for 4 weeks; then were divided at At the end of the study period nifedipine reduced supine random into two groups of 10 patients each. Nifedipine systolic blood pressure by 28 mm Hg and lacidipine by GITS, 30 mg and lacidipine, 4 mg, were given during 16 20 mm Hg. Heart rate was increased slightly but signifi- weeks of active treatment. Blood pressure and heart cantly in the nifedipine GITS group only in the standing rate were measured at the clinic in supine, sitting and position. -
Dorset Medicines Advisory Group
DORSET CARDIOLOGY WORKING GROUP GUIDELINE FOR CALCIUM CHANNEL BLOCKERS IN HYPERTENSION SUMMARY The pan-Dorset cardiology working group continues to recommend the use of amlodipine (a third generation dihydropyridine calcium-channel blocker) as first choice calcium channel blocker on the pan-Dorset formulary for hypertension. Lercanidipine is second choice, lacidipine third choice and felodipine is fourth choice. This is due to preferable side effect profiles in terms of ankle oedema and relative costs of the preparations. Note: where angina is the primary indication or is a co-morbidity prescribers must check against the specific product characteristics (SPC) for an individual drug to confirm this is a licensed indication. N.B. Lacidipine and lercandipine are only licensed for use in hypertension. Chapter 02.06.02 CCBs section of the Formulary has undergone an evidence-based review. A comprehensive literature search was carried out on NHS Evidence, Medline, EMBASE, Cochrane Database, and UK Duets. This was for recent reviews or meta-analyses on calcium channel blockers from 2009 onwards (comparative efficacy and side effects) and randomised controlled trials (RCTs). REVIEW BACKGROUND Very little good quality evidence exists. No reviews, meta-analyses or RCTs were found covering all calcium channel blockers currently on the formulary. Another limitation was difficulty obtaining full text original papers for some of the references therefore having to use those from more obscure journals instead. Some discrepancies exist between classification of generations of dihydropyridine CCBs, depending upon the year of publication of the reference/authors’ interpretation. Dihydropyridine (DHP) CCBs tend to be more potent vasodilators than non-dihydropyridine (non-DHP) CCBs (diltiazem, verapamil), but the latter have greater inotropic effects. -
Drug–Drug Salt Forms of Ciprofloxacin with Diflunisal and Indoprofen
CrystEngComm View Article Online COMMUNICATION View Journal | View Issue Drug–drug salt forms of ciprofloxacin with diflunisal and indoprofen† Cite this: CrystEngComm,2014,16, 7393 Partha Pratim Bag, Soumyajit Ghosh, Hamza Khan, Ramesh Devarapalli * Received 27th March 2014, and C. Malla Reddy Accepted 12th June 2014 DOI: 10.1039/c4ce00631c www.rsc.org/crystengcomm Two salt forms of a fluoroquinolone antibacterial drug, Crystal engineering approach has been effectively ciprofloxacin (CIP), with non-steroidal anti-inflammatory drugs, utilized in recent times in the synthesis of new forms particu- diflunisal (CIP/DIF) and indoprofen (CIP/INDP/H2O), were synthe- larly by exploiting supramolecular synthons. Hence the sized and characterized by PXRD, FTIR, DSC, TGA and HSM. Crystal identification of synthons that can be transferred across Creative Commons Attribution-NonCommercial 3.0 Unported Licence. structure determination allowed us to study the drug–drug different systems is important. For example, synthon trans- interactions and the piperazine-based synthon (protonated ferability in cytosine and lamivudine salts was recently dem- piperazinecarboxylate) in the two forms, which is potentially useful onstrated by Desiraju and co-workers by IR spectroscopy for the crystal engineering of new salt forms of many piperazine- studies.20a Aakeröy and co-workers successfully estab- based drugs. lished the role of synthon transferability (intermolecular amide⋯amide synthons) in the assembly and organization of Multicomponent pharmaceutical forms consisting of an bidentate acetylacetonate (acac) and acetate “paddlewheel” active pharmaceutical ingredient (API) and an inactive 20b complexes of a variety of metal(II)ions. Recently Das et al. co-former,whichisideallyagenerally recognized as safe – have reported the gelation behaviour in various diprimary This article is licensed under a 1 3 (GRAS) substance, have been well explored in recent times. -
(12) Patent Application Publication (10) Pub. No.: US 2010/0179214 A1 Dubé Et Al
US 20100179214A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0179214 A1 Dubé et al. (43) Pub. Date: Jul. 15, 2010 (54) DOXEPIN TRANS ISOMERS AND SOMERC continuation-in-part of application No. 1 1/804,720, MIXTURES AND METHODS OF USING THE filed on May 18, 2007. SAME TO TREAT SLEEP DSORDERS (60) Provisional application No. 60/898,378, filed on Jan. (75) Inventors: Susan E. Dubé, Carlsbad, CA (US); 30, 2007, provisional application No. 60/801,824, Neil B. Kavey, Chappaqua, NY filed on May 19, 2006, provisional application No. (US) 60/833,319, filed on Jul 25, 2006. Correspondence Address: KNOBBE MARTENS OLSON & BEAR LLP Publication Classification 2040 MAINSTREET, FOURTEENTH FLOOR (51) Int. Cl. IRVINE, CA 92.614 (US) A63L/335 (2006.01) A6IP 25/20 (2006.01) (73) Assignee: SOMAXON PHARMACEUTICALS, INC., (52) U.S. Cl. ........................................................ S14/450 San Diego, CA (US) (21) Appl. No.: 12/535,623 (57) ABSTRACT The invention relates to use of the trans-(E) isomer or iso (22) Filed: Aug. 4, 2009 meric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, phar Related U.S. Application Data maceutically-acceptable salts of doxepin and prodrugs of the (63) Continuation-in-part of application No. 12/022,788, same; compositions containing the same, for the treatment of filed on Jan. 30, 2008, now abandoned, which is a sleep disorders US 2010/0179214 A1 Jul. 15, 2010 DOXEPIN TRANS ISOMERS AND SOMERC brings scrutiny from the Drug Enforcement Administration MIXTURES AND METHODS OF USING THE and other regulatory bodies, and requires registration and SAME TO TREAT SLEEP DSORDERS administrative controls in physicians offices. -
PMBJP Product.Pdf
Sr. Drug Generic Name of the Medicine Unit Size MRP Therapeutic Category No. Code Analgesic & Antipyretic / Muscle 1 1 Aceclofenac 100mg and Paracetamol 325 mg Tablet 10's 10's 8.00 relaxants Analgesic & Antipyretic / Muscle 2 2 Aceclofenac Tablets IP 100mg 10's 10's 4.37 relaxants Acetaminophen 325 + Tramadol Hydrochloride 37.5 film Analgesic & Antipyretic / Muscle 3 4 10's 8.00 coated Tablet 10's relaxants Analgesic & Antipyretic / Muscle 4 5 ASPIRIN Tablets IP 150 mg 14's 14's 2.70 relaxants DICLOFENAC 50 mg+ PARACETAMOL 325 mg+ Analgesic & Antipyretic / Muscle 5 6 10's 11.30 CHLORZOXAZONE 500 mg Tablets 10's relaxants Diclofenac Sodium 50mg + Serratiopeptidase 10mg Tablet Analgesic & Antipyretic / Muscle 6 8 10's 12.00 10's relaxants Analgesic & Antipyretic / Muscle 7 9 Diclofenac Sodium (SR) 100 mg Tablet 10's 10's 6.12 relaxants Analgesic & Antipyretic / Muscle 8 10 Diclofenac Sodium 25mg per ml Inj. IP 3 ml 3 ml 2.00 relaxants Analgesic & Antipyretic / Muscle 9 11 Diclofenac Sodium 50 mg Tablet 10's 10's 2.90 relaxants Analgesic & Antipyretic / Muscle 10 12 Etoricoxilb Tablets IP 120mg 10's 10's 33.00 relaxants Analgesic & Antipyretic / Muscle 11 13 Etoricoxilb Tablets IP 90mg 10's 10's 25.00 relaxants Analgesic & Antipyretic / Muscle 12 14 Ibuprofen 400 mg + Paracetamol 325 mg Tablet 10's 15's 5.50 relaxants Analgesic & Antipyretic / Muscle 13 15 Ibuprofen 200 mg film coated Tablet 10's 10's 1.80 relaxants Analgesic & Antipyretic / Muscle 14 16 Ibuprofen 400 mg film coated Tablet 10's 15's 3.50 relaxants Analgesic & Antipyretic -
A Different Dihydropyridine Calcium Channel Blocker in Hypertensive Patients Who Developed Pedal Edema on Dihydropyridine Calcium Channel Blocker Therapy
Cumhuriyet Tıp Dergisi Cumhuriyet Tıp Derg 2014; 36: 19-24 Cumhuriyet Medical Journal Cumhuriyet Med J 2014; 36: 19-24 Original research-Orijinal araştırma http://dx.doi.org/10.7197/1305-0028.2102 A different dihydropyridine calcium channel blocker in hypertensive patients who developed pedal edema on dihydropyridine calcium channel blocker therapy Dihidropiridin grubu bir kalsiyum kanal blokeri tedavisi sırasında ayak bileği ödemi gelişen hipertansif hastalarda farklı bir dihidropiridin kalsiyum kanal blokerinin kullanımı Ayşe Yüksel, Ahmet Karagöz*, Özgül Uçar, Abdullah Çelik, Sinan Aydoğdu Department of Cardiology (A. Yüksel, MD), Abdurrahman Yurtaslan Oncology Education and Research Hospital, TR-06200 Ankara, Department of Cardiology (Assist Prof. A. Karagöz, MD), Giresun University, 28200, Giresun, Cardiovascular Surgery Clinic, (A. Çelik, MD), Giresun Professor Doctor Atilla İlhan Özdemir State Hospital, TR-28100 Giresun, Department of Cardiology (Assoc. Prof. Ö. Uçar, MD), Ankara Numune Education and Research Hospital, TR- 06230 Ankara, Department of Cardiology (Prof. S. Aydoğdu, MD), Yüksek İhtisas Education and Research Hospital, TR-06100 Ankara Abstract Aim. Dihydropyridine calcium channel blockers (CCB) are widely preferred for the treatment of hypertension for their efficacy, metabolic neutrality and low side effect profile. However pedal edema formation limits their usage. The aim of the present study is to evaluate the incidence of pedal edema formation with a different dihydropyridine CCB in hypertensive patients who developed pedal edema during a dihydropyridine CCB therapy. Method. Fifty-eight hypertensive patients (34 female, 24 male, mean age: 65.3±10.5) in whom pedal edema developed during treatment with a dihydropyridine CCB (amlodipine 10mg/day in 40 patients, amlodipine 5mg/day in 14 patients, nifedipine GITS 30mg/day in 4 patients) were enrolled. -
Lercanidipine Vs Lacidipine in Isolated Systolic Hypertension
Journal of Human Hypertension (2003) 17, 799–806 & 2003 Nature Publishing Group All rights reserved 0950-9240/03 $25.00 www.nature.com/jhh ORIGINAL ARTICLE Lercanidipine vs lacidipine in isolated systolic hypertension M Millar-Craig1, B Shaffu2, A Greenough3, L Mitchell3 and C McDonald3 1Department of Cardiology, Derbyshire Royal Infirmary, London Road, Derby, UK; 2Station Road Surgery, 152 Station Road, Wigston, Leicester, UK; 3Napp Pharmaceuticals Limited, Cambridge Science Park, Milton Road, Cambridge, UK This randomised, double-blind, double-dummy, parallel blood pressure was À0.81 (À4.45, 2.84) mmHg. These group, multicentre study compared the efficacy and confidence intervals were within the limits specified for tolerability of lercanidipine with lacidipine. Elderly equivalence, that is, (À5, 5) mmHg. Ambulatory blood patients with isolated systolic hypertension (supine pressure monitoring showed that the antihypertensive blood pressure X160/o95 mmHg) were enrolled and effects of both drugs lasted for the full 24-h dosing underwent a placebo run-in period of 14–27 days before period and followed a circadian pattern. Both treatments random allocation to lercanidipine tablets 10 mg once were well tolerated with a low incidence of adverse drug daily (n ¼ 111) or lacidipine tablets 2 mg once daily reactions and a low withdrawal rate. Significantly fewer (n ¼ 111) for the assessment period (112–160 days). patients withdrew from treatment with lercanidipine Titration to lercanidipine 20 mg once daily (two 10 mg (P ¼ 0.015). Neither treatment had any clinically signifi- tablets) or lacidipine 4 mg once daily (two 2 mg tablets) cant effect on pulse rate or cardiac conduction. -
The Repurposing Drugs in Oncology Database
ReDO_DB: the repurposing drugs in oncology database Pan Pantziarka1,2, Ciska Verbaanderd1,3, Vidula Sukhatme4, Rica Capistrano I1, Sergio Crispino1, Bishal Gyawali1,5, Ilse Rooman1,6, An MT Van Nuffel1, Lydie Meheus1, Vikas P Sukhatme4,7 and Gauthier Bouche1 1The Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium 2The George Pantziarka TP53 Trust, London, UK 3Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium 4GlobalCures Inc., Newton, MA 02459 USA 5Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 USA 6Oncology Research Centre, Vrije Universiteit Brussel, Brussels, Belgium 7Emory University School of Medicine, Atlanta, GA 30322 USA Correspondence to: Pan Pantziarka. Email: [email protected] Abstract Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as possible cancer treatments. The Repurposing Drugs in Oncology (ReDO) project has used a literature-based approach to identify licensed non-cancer drugs with published evidence of anticancer activity. Data from 268 drugs have been included in a database (ReDO_DB) developed by the ReDO project. Summary results are outlined and an assessment Research of clinical trial activity also described. The database has been made available as an online open-access resource (http://www.redo-project. org/db/). Keywords: drug repurposing, repositioning, ReDO project, cancer drugs, online database Published: 06/12/2018 Received: 27/09/2018 ecancer 2018, 12:886 https://doi.org/10.3332/ecancer.2018.886 Copyright: © the authors; licensee ecancermedicalscience. -
II~ R#I:C44kpu:Frt# PHILIPPINE HEALTH INSURANCE CORPORATION !I City State Centre Building # 709 Shaw Boulevard, Pasig City I Tel
II~ R#i:c44kPU:frt# PHILIPPINE HEALTH INSURANCE CORPORATION !I City State Centre Building # 709 Shaw Boulevard, Pasig City I Tel. 637-9999,637-6262 October 24, 2000 I PHILHEALTH CIRCULAR I No. 030, s-2000 '~ TO ALL MEMBERS OF THE NATIONAL HEJ;LTI-I INSURANCE PROGRAM, ACCREDITED INSTITUTIO:tjJAL AND I PROFESSIONAL HEALTH CARE PROVIIDERS, REGION},_L I HEALTH INSUM~CE OFFICES, CLAIM$ PROCESSING I DEPAKfMENTS IN THE CENTP.... AL OFdCE AND ALL OTHERS CONCERl~ED SUBJECT: List of additional rei11l.burseablc dtugs Ul.clud:ing over-the-counter I I drugs, found in the Philippine National Drug IFormularv I . II THE Philippme Health Insurance Corporation (Phill-lealth) has approved ~he following drugs for mclusion m Phili-Iealth's Positive List. These drugs can be found m the Clinical Practice Guidelines I (CPGs) for Hypertension, Urinary Tract Infection and Pneumonia. Claims ~or Medicare refund for I these drugs will be reimbursed only when used in the treatment of the disease1 indicated in the CPGs: I I DRUG CPG PREfARATION 1. Benazepril Hcl Hypertension Tablet 2. Bisoprolol Hypertension Tablet I 3. Cilazapril Hypertension Tablet 4. Doxazosin Hypertension Tablet 5.1sradipine Hypertension Tablet I 6. Lacidipine Hypertension i Tablet 7. Manidipine Hcl Hypertension Tablet 8. Perindopril Hypertension Tablet I 9. Quinapril Hypertension Tablet 10. Ramipril Hypertension Tablet 11. Delapril Hypertension Tablet I 12. Lisinopril Hypertension Tablet 13. Carteolol Hypertension Tablet 14. Oxprenolol Hypertension Tablet 15. Pindolol Hypertension Tablet ! I 16. Guanfacine Hypertension Tablet 17. Sodium Nitroprusside Hypertension Tablet 18. Nitrendipine Hypertension Tablet I Pneumonia O.!D-2.0g Vial 19. Cefamandole I 20. -
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Index Note: page numbers in italics refer to figures; those in bold to tables or boxes. abacavir 686 tolerability 536–537 children and adolescents 461 acamprosate vascular dementia 549 haematological 798, 805–807 alcohol dependence 397, 397, 402–403 see also donepezil; galantamine; hepatic impairment 636 eating disorders 669 rivastigmine HIV infection 680 re‐starting after non‐adherence 795 acetylcysteine (N‐acetylcysteine) learning disability 700 ACE inhibitors see angiotensin‐converting autism spectrum disorders 505 medication adherence and 788, 790 enzyme inhibitors obsessive compulsive disorder 364 Naranjo probability scale 811, 812 acetaldehyde 753 refractory schizophrenia 163 older people 525 acetaminophen, in dementia 564, 571 acetyl‐L‐carnitine 159 psychiatric see psychiatric adverse effects acetylcholinesterase (AChE) 529 activated partial thromboplastin time 805 renal impairment 647 acetylcholinesterase (AChE) acute intoxication see intoxication, acute see also teratogenicity inhibitors 529–543, 530–531 acute kidney injury 647 affective disorders adverse effects 537–538, 539 acutely disturbed behaviour 54–64 caffeine consumption 762 Alzheimer’s disease 529–543, 544, 576 intoxication with street drugs 56, 450 non‐psychotropics causing 808, atrial fibrillation 720 rapid tranquillisation 54–59 809, 810 clinical guidelines 544, 551, 551 acute mania see mania, acute stupor 107, 108, 109 combination therapy 536 addictions 385–457 see also bipolar disorder; depression; delirium 675 S‐adenosyl‐l‐methionine 275 mania dosing 535 ADHD