Nanotechnologies Concepts and Applications
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Gold Nanoshells
Nuclear Medicine and Biomedical Imaging Research Article Gold nanoshells: A ray of hope in cancer diagnosis and treatment Shanbhag PP*, Iyer V and Shetty T Saraswathi Vidya Bhavans College of Pharmacy, University of Mumbai, India Abstract Ideal properties of gold nanoshell has resulted in making it a ray of hope in biomedical areas such as targeted drug delivery, cancer detection and treatment and in eliminating tumors without harming normal healthy cells. Gold nanoshells are spherical particles with diameter ranging from 10-200 nm consisting of a dielectric core that is covered by a thin metallic shell of gold. An important role of gold nanoparticle based agents is their multifunctional nature. This review focuses on physics, synthesis and biomedical applications of gold nanoshells due to their inert nature, non-cytotoxicity and biocompatibility. Introduction Advantages The discovery of nanoshell was made by Professor Naomi J. 1. Biocompatibility Halas and her team at Rice University in 2003 [1,2]. Nanotechnologies Non-cytotoxicity can be defined as design, characterization, production and application 2. of structures, devices and systems by controlling shape and size at a 3. Bio sensing application nanometer scale [2,3]. Gold nanoparticles show different shapes as shown in Figure 1 [3]. 4. Protection of drugs from being degraded in the body before they reach their target site Nanoshell particles comprise of special class of nanocomposite materials [4]. Gold nanoshells are spherical nanoparticles composed 5. Enhance drug absorption into tumors and cancerous cells of a dielectric core which is covered by a thin gold shell with tunable 6. Prevention of drugs from interacting with normal cells, thus optical resonances [5,6]. -
Rise of the Molecular Machines Euan R
Angewandte. Essays International Edition: DOI: 10.1002/anie.201503375 Supramolecular Systems German Edition: DOI: 10.1002/ange.201503375 Rise of the Molecular Machines Euan R. Kay* and David A. Leigh* molecular devices · molecular machines · molecular motors · molecular nanotechnology Introduction inspirational in general terms, it is doubtful whether either of these manifestos had much practical influence on the devel- “When we get to the very, very small world … we have a lot of opment of artificial molecular machines.[5] Feynmans talk new things that would happen that represent completely new came at a time before chemists had the synthetic methods and opportunities for design … At the atomic level we have new kinds analytical tools available to be able to consider how to make of forces and new kinds of possibilities, new kinds of effects. The molecular machines; Drexlers somewhat nonchemical view problem of manufacture and reproduction of materials will be of atomic construction is not shared by the majority of quite different … inspired by biological phenomena in which experimentalists working in this area. In fact, “mechanical” chemical forces are used in a repetitious fashion to produce all movement within molecules has been part of chemistry since kinds of weird effects (one of which is the author) …” conformational analysis became established in the 1950s.[6] As Richard P. Feynman (1959)[2] well as being central to advancing the structural analysis of complex molecules, this was instrumental in chemists begin- It has long been appreciated that molecular motors and ning to consider dynamics as an intrinsic aspect of molecular machines are central to almost every biological process. -
Nanoscience and Nanotechnologies: Opportunities and Uncertainties
ISBN 0 85403 604 0 © The Royal Society 2004 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the UK Copyright, Designs and Patents Act (1998), no part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior permission in writing of the publisher, or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of licenses issued by the appropriate reproduction rights organization outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to: Science Policy Section The Royal Society 6–9 Carlton House Terrace London SW1Y 5AG email [email protected] Typeset in Frutiger by the Royal Society Proof reading and production management by the Clyvedon Press, Cardiff, UK Printed by Latimer Trend Ltd, Plymouth, UK ii | July 2004 | Nanoscience and nanotechnologies The Royal Society & The Royal Academy of Engineering Nanoscience and nanotechnologies: opportunities and uncertainties Contents page Summary vii 1 Introduction 1 1.1 Hopes and concerns about nanoscience and nanotechnologies 1 1.2 Terms of reference and conduct of the study 2 1.3 Report overview 2 1.4 Next steps 3 2 What are nanoscience and nanotechnologies? 5 3 Science and applications 7 3.1 Introduction 7 3.2 Nanomaterials 7 3.2.1 Introduction to nanomaterials 7 3.2.2 Nanoscience in this area 8 3.2.3 Applications 10 3.3 Nanometrology -
Surface-Enhanced Raman Scattering on Tunable Plasmonic Nanoparticle Substrates
Surface-enhanced Raman scattering on tunable plasmonic nanoparticle substrates J. B. Jackson*†‡ and N. J. Halas†‡§¶ሻ Departments of *Physics and Astronomy, §Electrical and Computer Engineering, and ¶Chemistry, †Laboratory of Nanophotonics, and ‡Rice Quantum Institute, Rice University, Houston, TX 77005 Communicated by James L. Kinsey, Rice University, Houston, TX, November 8, 2004 (received for review August 13, 2004) Au and Ag nanoshells are investigated as substrates for surface- the development of precisely designed nano-optical components enhanced Raman scattering (SERS). We find that SERS enhance- for SERS and other applications. ments on nanoshell films are dramatically different from those Independent control of the core and shell dimensions of observed on colloidal aggregates, specifically that the Raman nanoshells offers a valuable opportunity to systematically con- enhancement follows the plasmon resonance of the individual trol the plasmon resonance frequency of a nanostructure. The nanoparticles. Comparative finite difference time domain calcula- plasmon resonant frequency of a nanoshell can be tuned from tions of fields at the surface of smooth and roughened nanoshells the visible region of the spectrum into the infrared (19, 22–25), reveal that surface roughness contributes only slightly to the total giving rise to a host of useful applications (26–29). The plasmon enhancement. SERS enhancements as large as 2.5 ؋ 1010 on Ag resonances for Au and Ag nanoshells in this wavelength region nanoshell films for the nonresonant molecule p-mercaptoaniline are quite similar (22). The tunable plasmon frequency allows us are measured. to design substrates with plasmon resonances shifted far away from the electronic resonances of an adsorbate molecule, pro- nanoparticles ͉ nanoshells ͉ plasmons ͉ spectroscopy viding a strategy for separating the electromagnetic from the chemical effects in SERS. -
The Nanotoxicology of a Newly Developed Zero-Valent Iron
The nanotoxicology of a newly developed zero-valent iron nanomaterial for groundwater remediation and its remediation efficiency assessment combined with in vitro bioassays for detection of dioxin-like environmental pollutants Von der Fakultät für Mathematik, Informatik und Naturwissenschaften der RWTH Aachen University zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigte Dissertation vorgelegt von Diplom-Biologe Andreas Herbert Schiwy aus Tarnowitz (Polen) Berichter: Universitätsprofessor Dr. rer. nat. Henner Hollert Universitätsprofessor Dr. rer. nat. Andreas Schäffer Tag der mündlichen Prüfung 28. Juli 2016 Diese Dissertation ist auf den Internetseiten der Universitätsbibliothek online verfügbar. To my wife and my children Summary Summary The assessment of chemicals and new compounds is an important task of ecotoxicology. In this thesis a newly developed zero-valent iron material for nanoremediation of groundwater contaminations was investigated and in vitro bioassays for high throughput screening were developed. These two elements of the thesis were combined to assess the remediation efficiency of the nanomaterial on the groundwater contaminant acridine. The developed in vitro bioassays were evaluated for quantification of the remediation efficiency. Within the NAPASAN project developed iron based nanomaterial showed in a model field application its nanoremediation capabilities to reduce organic contaminants in a cost effective way. The ecotoxicological evaluation of the nanomaterial in its reduced and oxidized form was conducted with various ecotoxicological test systems. The effects of the reduced nanomaterial with field site resident dechlorinating microorganisms like Dehalococcoides sp., Desulfitobacterium sp., Desulfomonile tiedjei, Dehalobacter sp., Desulfuromonas sp. have been investigated in batch und column experiments. A short-term toxicity of the reduced nanomaterial was shown. -
Bottom-Up Self-Assembly Based on DNA Nanotechnology
nanomaterials Review Bottom-Up Self-Assembly Based on DNA Nanotechnology 1, 1, 1 1 1,2,3, Xuehui Yan y, Shujing Huang y, Yong Wang , Yuanyuan Tang and Ye Tian * 1 College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China; [email protected] (X.Y.); [email protected] (S.H.); [email protected] (Y.W.); [email protected] (Y.T.) 2 Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China 3 Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China * Correspondence: [email protected] These authors contributed equally to this work. y Received: 9 September 2020; Accepted: 12 October 2020; Published: 16 October 2020 Abstract: Manipulating materials at the atomic scale is one of the goals of the development of chemistry and materials science, as it provides the possibility to customize material properties; however, it still remains a huge challenge. Using DNA self-assembly, materials can be controlled at the nano scale to achieve atomic- or nano-scaled fabrication. The programmability and addressability of DNA molecules can be applied to realize the self-assembly of materials from the bottom-up, which is called DNA nanotechnology. DNA nanotechnology does not focus on the biological functions of DNA molecules, but combines them into motifs, and then assembles these motifs to form ordered two-dimensional (2D) or three-dimensional (3D) lattices. These lattices can serve as general templates to regulate the assembly of guest materials. In this review, we introduce three typical DNA self-assembly strategies in this field and highlight the significant progress of each. -
Intelligent Nanosystems Based on Molecular Motors
Digest Journal of Nanomaterials and Biostructures Vol. 4, No. 4, December 2009, p. 613 - 621 APPLICATIONS OF MOLECULAR MOTORS IN INTELLIGENT NANOSYSTEMS H. R. Khataeea, A. R. Khataeeb* aDepartment of Computer Engineering, Payam Noor University of Hashtrood, Hashtrood, Iran bCorresponding author: Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran All cells of living organisms contain complex transport systems based on molecular motors which enable movement on their polymer filaments. Molecular motors are responsible for various dynamical processes for transporting single molecules over small distances to cell movement and growth. Molecular motors are far more complex than any motors that have yet been artificially constructed. Molecular motors are ideal nanomotors because of their small size, perfect structure, smart and high efficiency. Recent advances in understanding how molecular motors work has raised the possibility that they might find applications as nanorobots. Constructing of biomimetic nanorobots and nanomachines that perform specific tasks is a long-term goal of nanobiotechnology. Thus, in this paper we have summarized some of potential applications of molecular motors. Our reviewing of potential applications of molecular motors indicates that these extraordinary systems can be had potential applications in nanorobots, nanodevices and nanomedicine. This review indicate that molecular motors might be the key to yet unsolved applications in vast variety of sciences that are only imagined today. (Received September 1, 2009; accepted Septemberv 27, 2009) Keywords: Nanobiotechnology, Nanorobots, Nanomachines, Nanodevices, Nanomedicine, Molecular motors 1. Introduction It is obvious that movement, in one form or another, is an essential feature of all life at both the macroscopic and cellular level. -
Nanomedicine and Medical Nanorobotics - Robert A
BIOTECHNOLOGY– Vol .XII – Nanomedicine and Medical nanorobotics - Robert A. Freitas Jr. NANOMEDICINE AND MEDICAL NANOROBOTICS Robert A. Freitas Jr. Institute for Molecular Manufacturing, Palo Alto, California, USA Keywords: Assembly, Nanomaterials, Nanomedicine, Nanorobot, Nanorobotics, Nanotechnology Contents 1. Nanotechnology and Nanomedicine 2. Medical Nanomaterials and Nanodevices 2.1. Nanopores 2.2. Artificial Binding Sites and Molecular Imprinting 2.3. Quantum Dots and Nanocrystals 2.4. Fullerenes and Nanotubes 2.5. Nanoshells and Magnetic Nanoprobes 2.6. Targeted Nanoparticles and Smart Drugs 2.7. Dendrimers and Dendrimer-Based Devices 2.8. Radio-Controlled Biomolecules 3. Microscale Biological Robots 4. Medical Nanorobotics 4.1. Early Thinking in Medical Nanorobotics 4.2. Nanorobot Parts and Components 4.3. Self-Assembly and Directed Parts Assembly 4.4. Positional Assembly and Molecular Manufacturing 4.5. Medical Nanorobot Designs and Scaling Studies Acknowledgments Bibliography Biographical Sketch Summary Nanomedicine is the process of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. UNESCO – EOLSS In the relatively near term, nanomedicine can address many important medical problems by using nanoscale-structured materials and simple nanodevices that can be manufactured SAMPLEtoday, including the interaction CHAPTERS of nanostructured materials with biological systems. In the mid-term, biotechnology will make possible even more remarkable advances in molecular medicine and biobotics, including microbiological biorobots or engineered organisms. In the longer term, perhaps 10-20 years from today, the earliest molecular machine systems and nanorobots may join the medical armamentarium, finally giving physicians the most potent tools imaginable to conquer human disease, ill-health, and aging. -
DNA Nanotechnology Meets Nanophotonics
DNA nanotechnology meets nanophotonics Na Liu 2nd Physics Institute, University of Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569 Stuttgart, Germany Email: [email protected] Key words: DNA nanotechnology, nanophotonics, DNA origami, light matter interactions Call-out sentence: It will be very constructive, if more research funds become available to support young researchers with bold ideas and meanwhile allow for failures and contingent outcomes. The first time I heard the two terms ‘DNA nanotechnology’ and ‘nanophotonics’ mentioned together was from Paul Alivisatos, who delivered the Max Planck Lecture in Stuttgart, Germany, on a hot summer day in 2008. In his lecture, Paul showed how a plasmon ruler containing two metallic nanoparticles linked by a DNA strand could be used to monitor nanoscale distance changes and even the kinetics of single DNA hybridization events in real time, readily correlating nanoscale motion with optical feedback.1 Until this day, I still vividly remember my astonishment by the power and beauty of these two nanosciences, when rigorously combined together. In the past decades, DNA has been intensely studied and exploited in different research areas of nanoscience and nanotechnology. At first glance, DNA-based nanophotonics seems to deviate quite far from the original goal of Nadrian Seeman, the founder of DNA nanotechnology, who hoped to organize biological entities using DNA in high-resolution crystals. As a matter of fact, DNA-based nanophotonics does closely follow his central spirit. That is, apart from being a genetic material for inheritance, DNA is also an ideal material for building molecular devices. -
Overview of DNA Self-Assembling: Progresses in Biomedical Applications
pharmaceutics Review Overview of DNA Self-Assembling: Progresses in Biomedical Applications Andreia F. Jorge 1 and Ramon Eritja 2,* 1 Coimbra Chemistry Centre (CQC), Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal; [email protected] 2 Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Jordi Girona 18-26, E-08034 Barcelona, Spain * Correspondence: [email protected]; Tel.: +34-934-006-145 Received: 22 November 2018; Accepted: 8 December 2018; Published: 11 December 2018 Abstract: Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and protein vehicles, as well as theranostic agents that are meant to operate in-cell and in-vivo. Keywords: DNA self-assembling; gene delivery; drug delivery; protein delivery; theranostics; nanomedicine 1. Introduction Nowadays, there is an increasing demand for developing predictive, preventive, and non-invasive patient-centered medicines, ideally combining diagnosis and therapeutics in one single device to enabling early diagnosis, precise treatment, and management of a specific disease, with power to leverage the quality of medical care [1]. -
DNA-Based Artificial Nanostructures: Fabrication, Properties And
(Invited) Chapter V in “Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology,” Vols. 1-2 (ISBN: 1-58883-033-0), edited by Nalwa, American Scientific Publishers (2005). DNA-based Artificial Nanostructures: Fabrication, Properties, and Applications Young Sun and Ching-Hwa Kiang* Department of Physics & Astronomy, Rice University 6100 Main Street - MS61, Houston, TX 77005, USA Phone: (713) 348-4130, Fax: (713) 348-4150, E-mail: [email protected] Keywords: DNA; nanostructure; self-assembly; nanoparticle; carbon nanotube; biosensor. *To whom correspondence should be addressed: [email protected]. 1 Table of Content 1. Introduction 2. DNA fundamentals 3. Attachment of DNA to surface 4. Fabrication of nanostructures using DNA 4.1 Nanostructures of pure DNA 4.2 DNA-based assembly of metal nanoparticles 4.3 Construction of semiconductor particle arrays using DNA 4.4 DNA-directed nanowires 4.5 DNA-functionalized carbon nanotubes 4.6 Field-transistor based on DNA 4.7 Nanofabrication using artificial DNA 5. DNA-based nanostructures as biosensors 6. Properties of DNA-linked gold nanoparticles 6.1 Aggregation of DNA-modified gold nanoparticles 6.2 Melting of DNA-linked gold nanoparticle aggregations 6.3 Effects of external variables on the melting properties 7. Conclusion 2 1. Introduction The integration of nanotechnology with biology and bioengineering is producing many advances. The essence of nanotechnology is to produce and manipulate well- defined structures on the nanometer scale with high accuracy. Conventional technologies based on the "top-down” approaches, such as the photolithographyic method, are difficult to continue to scale down due to real physical limitations including size of atoms, wavelengths of radiation used for lithography, and interconnect schemes. -
Nanotechnology and Health Risks
NANOTECHNOLOGY AND HEALTH RISKS Nanotechnology is being hailed as the “next industrial revolution”. Nanomaterials are now found in hundreds of products, from cosmetics to clothing to food products. Inevitably, these nanomaterials will enter our bodies as we handle nanomaterials in the workplace, eat nano-foods, wear nano-clothes and nano- cosmetics, use nano-appliances and dispose of nano waste into the environment. Early scientific studies demonstrate the potential for materials that are benign in bulk form to become harmful at the nanoscale. There is an urgent need for regulations to protect workers, the public and the environment from nanotoxicity’s risks, for greater understanding of the short and long-term implications of nanotechnology for people’s health and the environment, for consideration of nanotechnology’s broader social implications and for public involvement in decision making regarding nanotechnology’s introduction. What is “nanotechnology” and how is it used? “Nanotechnology” refers to the design, production and application of structures, devices or systems at the incredibly small scale of atoms and molecules – the “nanoscale”. “Nanoscience” is the study of phenomena and the manipulation of materials at this scale, generally understood to be 100 nanometres (nm) or less1. To put 100nm in context, a single strand of DNA measures 2.5nm across, red blood cells measure about 7,000nm and a human hair is 80,000nm wide. Most observers do not make a distinction between nanotechnology and nanoscience and use the term nanotechnology to encompass production and use of nanoscale materials (“nanomaterials”). Nanomaterials are “first generation” products of nanotechnology and FACT SHEET have already entered wide-scale commercial use.