www.impactjournals.com/oncotarget/ Oncotarget, 2017, Vol. 8, (No. 30), pp: 49110-49122 Research Paper Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression Yan Chen1,2,*, Shai Huang2,*, Bo Wu3,*, Jiankai Fang2, Minsheng Zhu2, Li Sun4, Lifeng Zhang1, Yongsheng Zhang5, Maomin Sun4, Lingling Guo2 and Shouli Wang2,6,7 1Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China 2Department of Pathology, School of Biology ﹠ Basic Medical Sciences, Soochow University, Suzhou 215123, China 3Department of Surgery, The People’s Hospital of Sihong County, Sihong 223900, Jiangsu Province, China 4Laboratory Animal Research Center, Soochow University School of Medicine, Suzhou 215123, China 5Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China 6Laboratory of Molecular Pathology, Soochow University ﹠ Sihong County People’s Hospital, Suzhou 215123, China 7Suzhou Key Laboratory of Tumor Microenvironment and Pathology, Soochow University, Suzhou 215006, China *These authors have contributed equally to this work Correspondence to: Shouli Wang, email:
[email protected] Lingling Guo, email:
[email protected] Keywords: microRNA, miR-196a-3p, transforming growth factor-ß1, breast cancer Received: December 12, 2016 Accepted: February 23, 2017 Published: March 17, 2017 Copyright: Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Transforming growth factor-β1 is considered a key contributor to the progression of breast cancer. MicroRNAs are important factors in the development and progression of many malignancies.