USER GUIDE

Optum Clinformatics Data Mart Database

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TABLE OF CONTENTS TOPIC PAGE # 1. REQUESTING DATA 3 Eligibility 3 Forms 3 Contact Us 4 2. WHAT YOU WILL NEED 4 SAS Software 4 VPN 5 3. ABSTRACTS, MANUSCRIPTS, THESES, AND DISSERTATIONS 5 Referencing Optum Data 5 Optum Review 5 4. DATA USER SET-UP AND ACCESS INFORMATION 6 Server Log-In After Initial Set-Up 6 Server Access 6 Establishing a Connection to Enterprise Guide 7 Instructions to Add SAS EG to the Cleared Firewall List 8 How to Proceed After Connection 8 5. BEST PRACTICES FOR DATA USE 9 Saving Programs and Back-Up Procedures 9 Recommended Coding Practices 9 6. APPENDIX 11

Version Date: 27-Feb-17

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Optum® ClinformaticsTM Data Mart Database

The Optum® ClinformaticsTM Data Mart is an administrative health claims database from a large national insurer made available by the University of Rhode Island College of Pharmacy. The statistically de-identified data includes medical and pharmacy claims, as well as laboratory results, from 2010 through 2013 with over 22 million commercial enrollees.

1. REQUESTING DATA

The following is a brief outline of the process for gaining access to the data.

Eligibility  Must be an employee or student at the University of Rhode Island conducting unfunded or URI internally funded projects.

Data will be made available to the following users:

1. Faculty and their research team for projects with IRB approval. 2. Students a. With a thesis/dissertation proposal approved by IRB and the Graduate School (access request form, see link below, must be signed by Major Professor). b. Non-thesis/dissertation projects approved by IRB (access request form, see link below, must be signed by faculty principal investigator). 3. Must be an enrolled student or employee for at least 3 months prior to access.

 Please contact the database manager if you would like to request access for non-employees of URI.

Forms  Everyone accessing the data must complete the Optum Acknowledgment of Personnel Form, including major professors and principal investigators and submit the signed form to the Optum Database Manager ([email protected]) using an URI email address.  The Optum Database Manager will then send the CONFIDENTIAL Data Dictionary.  For IRB approval, submit the Optum Database Memo with the secondary data analysis sheet to the IRB.

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 Once a proposal has received IRB and Graduate School (where applicable) approval, submit the URI COP Optum Clinformatics Access Request Form and associated Excel file (complete using the Data Dictionary), the IRB approval letter, and the Graduate School proposal acceptance notification (where applicable) to the Optum Database Manager.

 See detailed explanation below:

Submit an Excel document with your request which includes all International Classification of Diseases, 9th Revision (ICD-9) diagnosis and procedure codes, medication names, and/or National Drug Codes (NDCs) required for building your study cohort. All values must be listed out, ranges or higher-level categories will not be accepted, and unique values listed on separate rows. Diagnosis codes should be submitted as the full diagnosis code without a decimal (for example, diabetes without complications: 25000, 25001, 25002, and 25003). NDCs should be submitted as eleven-digit strings (for example, insulin, glucoreg: 43742- 0398-1 would be 43742039810; instructions for formatting can be found in the appendix). Medication names should be provided as all uppercase and include both the generic and brand names (for example: brand ALIMTA or ingredient PEMETREXED). You will be provided all four years of data 2010-2013, unless otherwise specified. You may find NDC codes by downloading an exported Excel file from the Food and Drug Administration’s website using “active ingredient” as your search criteria in order to include any generic drugs. You may also wish to check Micromedex, as the University has a subscription. You can ask the database manager about who to contact for access. See Appendix for help with NDC code generation.

Contact Us  Optum Database Manager: [email protected]

2. WHAT YOU WILL NEED

SAS Software  If you do not already have SAS installed on your personal computer, you can go to the following site where you will be provided with instructions on obtaining SAS.  http://web.uri.edu/its/its-handouts/handout-61/  Be sure to select Enterprise Guide as part of the download package.

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VPN  Go to https://security.uri.edu/forms/vpn  Fill in VPN Request Form.  When a token has been created, you will receive an email to pick up your token with a URL of how to establish the VPN.  If an issue arises with the following message after you have attempted to log-in follow the directions below:

Solution o Click Start and type regedit in the Search field and hit enter. o Navigate to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\CvirtA o Find the String Value called DisplayName. o Right click and select Modify from the context menu. o In Value data, remove @oemX.inf,%CvirtA_Desc%;. The Value data should only contain Cisco Systems VPN Adzapter for 64-bit Windows. o Click Ok. o Close Registry Editor. o Retry your Cisco VPN Client connection.

3. ABSTRACTS, MANUSCRIPTS, THESES, AND DISSERATATIONS

Referencing Optum Data  Data source: Optum Clinformatics Data Mart (OptumInsight, Eden Prairie, MN)  Optum Clinformatics Data Mart is an administrative health claims database from a large national insurer.

Optum Review  At least 10 business days prior to publication: abstracts, manuscripts, theses, and dissertations should be submitted to Optum for review. These materials are reviewed to verify (a) correct referencing of the Optum data and (b) inclusion of only summary or

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aggregate data in the publication. [email protected]; [email protected]; [email protected]  The Optum review will be completed within 10 business days and required changes will be communicated if necessary. If Optum does not respond within 10 business days, this means no changes are required and you may proceed with the publication.  Failure to comply with this requirement may result in removal of access and project termination.

4. DATA USER SET-UP AND ACCESS INFORMATION

Server Log-In After Initial Set-Up  A user name and password will be established for you by the Database Administrator following approval of the required data use agreements and other forms.  The user name and password grants you access to a folder to both the graduate student researcher and his/her major professor OR if research is conducted solely by the principal investigator only he/she will receive access.  The project password should be kept confidential and only shared among approved members of the project.

Server Access  If you are using Windows 8 (if another version, find the Search option):  Go to windows search option-> then type ‘notepad’ -> right click the notepad icon -> click “Run as administrator” (see below pic).

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 Windows will ask for confirmation, click yes.  This will open the notepad file -> click file -> click open -> Now go to the below path “ C:\Windows\System32\drivers\etc”.  Once you get to the above mentioned folder, in the bottom right corner, change the document type from “Text documents (*.txt) to “All files (*.*). This option will make ‘hosts’ file visible.  Click file ‘hosts’.  This file will open in a notepad.  You will see the below content. (see below image)

 After the last line, type: 131.128.88.82 df3sx182 on one line and 131.128.88.82 df3sx182.uri.edu on the next line. BE SURE TO EXCLUDE THE HASHTAGS.  Save file -> Close file.

Establishing a Connection to Enterprise Guide  Now open SAS Enterprise (for this you can once again go to Windows search and type “SAS Enterprise” & then left-click SAS Enterprise icon).  On the bottom right corner of SAS Enterprise, you will see “no profile selected” in blue letters.

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 Click “no profile selected”.  Click “Add profile”.  Enter the following: o Name -> USERNAME o Description -> leave blank o Machine -> click option ‘remote’ o In the empty space below type -> 131.128.88.82 o Port-> 8561 o Put your username df3sx182\[USERNAME] and password o Authentication Doman -> leave blank o Click Save.  Now double-click your profile & you should get the pop-up which would request you to log- in to access Premier data.

Instructions to Add SAS EG to the Cleared Firewall List

If you are using Windows:  Go to windows search option-> then type “firewall”.  Click on the first option “Windows firewall”. This will open Windows firewall.  Click the option “Allow an app or feature through Windows Firewall” (it’s on the upper left corner).  Click “Allow another app…” (SOMETIMES you have to click on “change settings” option before that).  From the list of apps, select “SAS Enterprise Guide 6.x”.  Click Add button.  Click Ok button at the bottom.

How to Proceed After Connection  Once you have connected to Enterprise Guide, you will see a window in the lower left corner of your screen. This window is defaulted to the Server List. In the Server List pane, you will see ‘Servers’, which you will expand and see SASApp. Expand again and you will see Libraries and Folders. The data you will be using is under your initials in the Libraries list. You will need to refer to the Optum Codebook for information on variables and tables.  You can save your SAS programs in the SAS Folders window by going to File  Save Program As…  SASApp  Files then selecting your folder.  Users must use the following code to query their library: o Libname XXX Meta Metaout=data Library= ‘XXX’; options = max;

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5. BEST PRACTICES FOR DATA USE

Saving Programs and Back-Up Procedures  Save copies of your SAS programs on your personal computer but remember no data can be saved off of the server. Programs should be saved prior to executing the program in case the system has to be restarted unexpectedly.  Remember to back-up programs to an external drive in case your primary machine becomes inaccessible.  The COP is not responsible for corrupted or overwritten data files, or any unsaved data or programs.

Recommended Coding Practices  Using Comments o At the beginning of each program, include the author, date, and purpose of the program. o Include comments describing the purpose of different data steps.

Data yyy; /*creating a work data set so as to not overwrite a permanent data set*/ set opt.yyz ; run; /*sorting new table for merging of data sets in following step*/ Proc sort data=yyy; by id; run;

 Overwriting Programs and Datasets o Previous versions of programs and datasets will not be saved on the server, therefore overwritten programs and datasets cannot be recovered.

 Zipped Datasets o Large raw and intermediate datasets should be zipped to conserve space. o Reading a ZIP File Member from a Directory (In SAS 9.4 only) . The following example reads the test1.txt ZIP file member from the testzip ZIP file.

Filename xxx ZIP ‘U:\directory1\testzip.zip’ member=”test1.txt” ; data _null_; infile xxx; input a $80.;

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run;

o Writing a ZIP File to a New Member of a Directory . The following example writes the shoes file to the testzip ZIP file.

Filename xxx ZIP ‘U:\directory1\testzip.zip’; data _null_; file xxx(shoes); set sashelp.shoes; put region $25. Product $14.; run;

o Reading from a Member of a Directory . This example reads the file shoes from the testing1ZIP file.

Filename xxx ZIP ‘U:\directory1\testzip.zip’; data shoes; length region $25 product $14; infile xxx(shoes); input region $25. Product $14.; run;

 Saving Datasets o Saving a final permanent dataset xxx.yyy versus intermediate dataset as work.yyy.

Libname X ‘C:\folder_name”; Data yyy; Set Opt.yyz (keep= var1 var2 var3); where var2 in (‘1720’,’1723’,1729’); run; Data final.yyy; set yyy; run;

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6. APPENDIX

National Drug Code Formatting

 Use FDA website: http://www.accessdata.fda.gov/scripts/cder/ndc/default.cfm 

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 Search by using Type and inputting the medication name.

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 Download to Excel.

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 Excel file design.

o Insert 3 Columns After Column D.

o In Column E type the following formula: =MID(D2,SEARCH("(",D2)+1,SEARCH(")",D2)-SEARCH("(",D2)-1) This will remove the NDC code from column.

o Go to the Data Tab on the ribbon and select Text to Columns. Choose Delimited. For Delimiter options check Other and type in a dash “-“. Click Finish.

Insert a column after each of these three columns. After the first column type the following code: =IF(LEN(F2)=5,F2,TEXT(F2,"00000")). After the second (or 4-digit NDC portion of the code) enter this code: =IF(LEN(H2)=4,H2,TEXT(H2,"0000")). Next, enter

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this code after the last portion of the NDC code: =IF(LEN(J2)=2,J2,TEXT(J2,"00")). As you can see from the formula, it is converting each portion of the 5-4-2 NDC code by adding in a leading zero. Verify that these numbers are correct by looking at the original column (D).

Create 2 more columns (L and M). In column L we want to pull these numbers together so that we have the correct 11-digit format for Optum. Use the following code to do so: =CONCATENATE(G2,I2,K2) o In column M, we are going to copy column L and paste special values in column M. This is your final product. An 11-digit string of numbers with zeroes in all of the right places.

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