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SARG 2020 WORKING PROGRAM

Sunday, May 30, 2021 Workshop A Workshop B 09:00-16:00 Fertility Preservation Hands-on Workshop on Ovarian tissue 14:00-18:30 Preimplantation genetic testing (PGT): Latest insight cryopreservation & transplantation 9:15-9:30 Registration & Welcoming words 14:00-14:40 Opening remarks Avner Hershlag, USA – Course Chairman 9:30-10:00 Fertility Preservation & Effects of radio/chemo therapy on reproduction. 14:10-14:40 Genetics 101 TBA Yuval Yaron, Israel 10:00-10:30 Cryopreservation of ovarian tissue 14:40-15:10 The impact of embryo biopsy and the quality of the embryology lab Dror Meirow, Israel Colleen Lynch, UK 10:30-11:00 Laboratory practical aspects: Tissue transportation, preparation, 15:10-15:40 Prevention of genetic disease through PGT-M cryopreservation – thawing, quality control Avner Hershlag, USA Daniela Nogueira, France 11:00-11:30 The safety of harvesting ovarian tissue for fertility preservation 15:40-16:00 Coffee Break Hila Raanani, Israel 11:30-12:00 Transplantation of ovarian tissue 16:00-16:30 PGT-A: Inclusion and exclusion criteria Dror Meirow, Israel Joe Leigh Simpson, USA 12:00-13:00 Lunch break 16:30-17:00 Mosaicism Santiago Munne, Spain 13:00–16:00 Hands-On 17:00-17:30 Chromosomal mosaicism in humans: clinical implications for prenatal diagnosis and non-invasive prenatal testing Brynn Levy, USA Clinical dilemmas 17:30-18:30 Panel discussion: ethical issues in PGT Laboratory, surgical Patient cases for Fertility Daniela Nogueira, France; Itay Preservation Spector, Israel; Yuval Yung, Israel; Hila Raanani, Israel; Dror Meirow, Dror Meirow, Israel Israel Israeli Center for Medical Simulation Israeli Center for Medical Simulation (MSR) (MSR) 19:00 Welcome Reception Monday, May 31, 2021 08:30-10:00 Session 1A: Challenges in ART for patients with specific pathologies 08:30-10:00 Session 1B: Innovation in reprieve medicine Chairs: Ester Polak, Argentina, Sergio Papier, Argentina, Alejandro Manzur, Chairs: Ido Ben Ami, Israel, Arik Kahane, Israel, Ettie Maman, Israel Argentina 08:30-09:00 PCOS and ART: Recommendations on the new 2018 International Evidence- 08:30-09:00 Egg donation - fresh or frozen - exclusive or Shared Based Guidelines Tomer Singer, USA Ricardo Loret de Mola, Mexico / USA 09:00-09:30 Optimizing ART results in patients with endometriosis 09:00-09:30 How to change the endometrial microbiome Marcelo Barrionuevo, Argentina / USA David Keefe, USA 09:30-10:00 The Biological Clock and Fertility Preservation in Cancer and Non Cancer 09:30-10:00 Novel methods for ovarian stimulation Patients Robert Fischer, Germany Marcelo Barrionuevo, Argentina / USA 10:00-10:20 Coffee break, poster viewing & visit the exhibition 10:20-11:40 Session 2A: Opening Session 10:20-10:40 Welcome and Opening Note Zeev Shoham, Israel; Michael Alper USA; Adrian Shulman, Israel; Avner Hershlag USA 10:40-11:10 Reflections on the current and future relationship between industry and physicians as technology continues to evolve Introduction: Avner Hershlag, USA Robert Auerbach, USA 11:10-11:40 Predict the unpredictable - the science and magic behind AI Introduction: Benjamin Reubinoff, Israel Eran Eshed, Israel 11:40-11:50 Technical break

11:50-13:20 Session 3A: Innovation in Reproductive medicine 11:50-13:20 Session 3B: Reproductive Nuclear Transfer: Novel challenges and clinical application Chairs: Ramon Aurel Ballesteros, Spain ; Shachar Kol, Israel Chair: Ilan Tur-Kaspa, USA 11:50-12:20 Uterine microbiome and human reproduction: current status 11:50-12:10 Reproductive nuclear transfers in human reproduction Carlos Simon, Spain John Zhang, USA 12:10-12:30 Clinical aspects of reproductive nuclear transfers Valery Zukin, Ukraine 12:20-12:50 Creating a crossroad between science and the laboratory in IVF 12:30-12:50 Technical aspects of NT in different stages Denny Sakkas, USA Pavlo Mazur, Ukraine 12:50-13:20 Non-invasive PGT-A: is this the future or an illusion? 12:50-13:10 Heteroplasmy in babies born after RNT: Genetic safety Carlos Simon, Spain Dmytro Mykytenko, Ukraine 13:10-13:20 Discussion 13:20-14:00 Lunch break, poster viewing & visit the exhibition 14:00-15:30 Session 4A: New developments in Reproductive Medicine 14:00-15:30 Session 4B: Reproductive Genetics 1 14:00-15:30 Session 4C : Making Parenthood Chairs: Benny Fisch, Israel; Anat Hershko Klement, Israel; Raphael Ron-El, Chairs: Martha Direnfeld, Israel; Johnny Younis, More Possible by Selecting Better Israel Israel Sperm: Transforming Sperm Preparation to Optimize Outcomes Chair: Neri Laufer, Israel 14:00-14:30 TBA 14:00-14:30 Basic genetics principles for the non-genetics 14:00-14:05 Introduction: Shelley Amster, USA Yuval Yaron, Israel 14:05-14:20 Current treatment approaches and the importance of ‘healthy’ sperm. Avraham Harlev, Israel 14:20-14:35 A microfluidic device mimics natural sperm separation Matt Feldman, USA 14:30-15:00 Allogeneic uterus transplantation: A Novel reproductive transplant 14:30-15:00 Whole exome & genome sequencing in prenatal 14:35-14:55 A novel approach to select Rebecca Flyckt, USA diagnosis spermatozoa with the highest Brynn Levy, USA genomic integrity Philip Xie, USA 15:00-15:30 Non-surgical treatment of endometriosis 15:00-15:30 The genetics of fertilization failures: from diagnosis 14:55-`15:15 How to improve PGT and outcomes Mark Hornstein, USA to treatment – case study Rita Vassena, Spain David Keefe, USA 15:15-15:30 Interactive panel discussion with faculty and attendees 15:30-16:00 Coffee break, poster viewing & visit the exhibition 16:00-18:00 Session 5A: How do we deal with the poor responder patient and 16:00-18:00 Session 5B: Reproductive Genetics 2 16:00-17:30 Session 5C: This is the way we do fertilization failure Chair: Talia Eldar-Geva, Israel; Neri Laufer, Israel it Chairs: Norbert Gleicher, USA; Shlomo Mashiach, Israel; Yoel Shufaro, Chair: Miriam Almgor, Israel; Israel 16:00-16:30 Ovarian Rejuvenation 16:00-16:30 PGT-M for adult onset conditions? 16:00-16:15 Freezing a single sperm Antonio Pellicer, Spain Joe Leigh Simpson, USA Pavel Itsykson, Israel 16:30-17:00 Growth Hormone: As an adjuvant for women classified as poor prognosis in 16:30-17:00 The clinical utility of PGT-A 16:15-16:30 Non-invasive embryo assessment IVF Santiago Munne, USA by testing culture media or using John Yovich, Australia advanced microscopy Denny Sakkas, USA 17:00-17:30 Manipulating primordial follicle activation in vitro 17:00-17:30 Gene editing using CRISPR/Cas9 in Human Embryos 16:30-16:45 How do we select the best sperm Evelyn Telfer, UK Gerald Schatten, USA for ICSI via IMSI Guy Cassuto, France 17:30-18:00 How do we explain dramatic declines in live births after IVF? 17:30-18:00 Chances and risks of RCTs in preimplantation genetic 16:45-17:00 How do we treat immotile sperm Norbert Gleicher, USA screenings TBA Andreas Schmutzler, Germany 17:00-17:15 How do we treat testicular sperm tissue (TESA)? Pavel Itsykson, Israel; Peter Schlegel, USA

Tuesday, June 1, 2021 07:30-08:45 Breakfast session: Publish or Perish: meet the Editor-in-chief of the leading journals in our field Moderator: Ariel Weissman, Israel Alan DeCherney, USA - Global Reproductive Health Topics for discussion include: Cornelis (Nils) Lambalk, The Netherlands - Human Reproduction • The transition to open access journals Craig Niederberger, USA - Fertility and Sterility • Publishing journals in electronic form only Galia Oron, Israel - Associate Editor, Human reproduction • Hosting more digital platforms for presenting data Antonio Pellicer, Spain - Fertility and Sterility • Preventing misinformation • Why people should invest their time reviewing papers • Tips for young researchers • Other topics 09:00-10:30 Session 6A: Lessons learned from managing an IVF Centre – Boston IVF 09:00-10:30 Session 6B: AI Reproductive Care Session Chairs: Raoul Orvieto, Israel; Einat Shalom Paz, Israel; Seang Lin Tan, Chair: Daniela Gilboa, Israel; Ariel Hourvitz, Israel; Eliahu Levitas, Israel; Canada 09:00-09:30 How do you know that your IVF Program is good? 09:00-09:30 Challenges and pitfalls in applying machine learning and computer vision to medical care Michael Alper, USA Assaf Zaritsky, Israel 09:30-10:00 Future training of reproductive specialists 09:30-10:00 ART and AI: Revolution or Evolution? Alan Penzias, USA Daniel Seidman, Israel. 10:00-10:30 The challenging and reward in clinical reproductive research 10:00-10:30 Implementation of Artificial Intelligence in the IVF Lab: What Will the Future Hold? Robert Casper, Canada Marcus Meseguer, Spain 10:30-11:00 Coffee break, poster viewing & visit the exhibition 11:00-13:00 Session 7A: Future reproductive science: A new approach 11:00-13:00 Session 7B: Endometriosis 11:00-13:20 Session 7C : This is the way we Chairs: Roy Homburg, UK; Gad Lavy, USA; Amir Weintraub, Israel Chairs: Chen Goldschmit, Israel; Daniel Seidman, do it Israel; Moti Goldenberg, Israel 11:00-11:25 The enigma of PCOS 11:00-11:30 Endometrioma and ovarian reserve: 11:00-11:15 Selection of embryo for transfer Roy Homburg, UK Ethiopathogenesis and management using AI demonstration of the Ceana Nezhat, USA technique Asaf Ben Meir, Israel 11:15-11:30 Nuclear transfer: How this is being performed Pavlo Mazur, Ukraine 11:25-11:50 How can we improve our management of recurrent implantation failure? 11:30-12:00 Cancer Arising from Endometriosis: What fertility 11:30-11:45 Trophoectoderm biopsy Nick Macklon, UK specialists should know Miriam Almgor, Israel Farr Nezhat, USA 11:45-12:00 IVM retrieval for oocyte in vitro maturation (IVM) Daniela Nogueira, France 11:50-12:15 New ovarian stimulation strategies 12:00-12:30 Treatment of endometriosis with Dopamine Agonists 12:00-12:20 Cytoplasmic and mitochondrial Sesh Sunkara, UK Antonio Pellicer, Spain transfer John Zhang, USA 12:15-12:40 The uterus - the neglected incubator? 12:30-13:00 Improving education and training for endometriosis: 12:20-12:40 Getting MII oocytes Ying Cheong, UK A Reluctant Critic: Why Gynecologic Surgery Needs simultaneously with ovary Reform tissue freezing without any Louise King, USA stimulation TBA 12:40-13:00 Balancing risks benefits on potential high responders 12:40-13:00 TBA Tal Shavit, Israel Marcos Meseguer, Spain 13:00-14:00 Lunch break, poster viewing & visit the exhibition

14:00-16:00 Session 8A: The male 14:00-16:00 Session 8B: New innovation in reproductive medicine Chairs: Ilan Calderon, Israel; Shevach Friedler, Israel; Arieh Raziel, Israel Chairs: Vani Patel, India; ; Jaron Rabinovici, Israel 14:00-14:45 Controversies and consensus in Azoospermia 14:00-14:30 Automated vitrification Craig Niederberger, USA Pasquale Patrizio, USA Peter Schlegel, USA 14:30-15:00 Freeze dry technology: Show me the evidence Amir Arav, Israel 14:45-15:15 Making Sperm from Skin Cells 15:00-15:30 Engineering a Bioprosthetic Ovary with 3D Printing TBA Monica Laronda, USA 15:15-15:45 The correlation between high magnification of the sperm and the 15:30-16:00 AMH with PCOS; the victim or the suspect? methylation of the genes Cornelis (Nils) Lambalk, The Netherlands Nino Guy Cassuto, France 15:45-16:00 Discussion 16:00-16:15 Coffee break, poster viewing & visit the exhibition 16:15-18:15 Session 9A: Fertility preservation and cancer prevention Chairs: Michael Alper, USA; Jehoshua Dor, Israel; Avner Hershlag, USA 16:15-16:45 Fertility Preservation in patients with rare genetic diseases Alan DeCherney, USA 16:45-17:15 Ovarian tissue conservation program as a standard clinical practice Dror Meirow, Israel 17:15-17:45 Cancer prevention through ART Avner Hershlag, USA 17:45-18:15 Evolving ovarian tissue from fertility preservation to hormonal preservation for natural menopause protection Simon Fishel, UK