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Non-Infective Endocarditis

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Non-Infective Endocarditis Education in Heart Heart: first published as 10.1136/heartjnl-2019-315204 on 6 May 2020. Downloaded from VALVULAR HEART DISEASES Non- infective endocarditis Harriet Hurrell, Ross Roberts-­Thomson, Bernard D Prendergast ► Additional material is INTRODUCTION Learning objectives published online only. To view Endocarditis is defined as inflammation of the please visit the journal online endocardium, the lining of the cardiac chambers (http:// dx. doi. org/ 10. 1136/ To outline the causes and epidemiology of non- and valves, and characterised by vegetations, most ► heartjnl- 2019- 315204). infective endocarditis. commonly caused by infection with bacteria or To explore the pathophysiology of non- infective Department of Cardiology, St fungi. Non- infective endocarditis, also known as ► endocarditis. Thomas’ Hospital, London, UK non- bacterial thrombotic endocarditis (NBTE) To discuss the appropriate investigation or aseptic endocarditis, refers to a rare condi- ► Correspondence to of patients with suspected non- infective tion characterised by formation of sterile vegeta- Dr Harriet Hurrell, St Thomas’ endocarditis. Hospital Department of tions. Without treatment, these can lead to valve ► To highlight the key principles of management Cardiology, London, Greater dysfunction, heart failure, systemic embolism of non- infective endocarditis and when surgical London, UK; and death. Herein, we review the pathophysi- intervention should be considered. h. e. l. hurrell@ doctors. org. uk ology, clinical features, diagnosis and treatment Published Online First of NBTE. 6 May 2020 aetiology, highlighting the likely under- estimation BACKGROUND of immune- mediated causes. The first description of sterile vegetations on the Echocardiographic studies have found vegeta- heart valves was provided by Zeigler in 1888.1 tions in 11% of patients with SLE and no evidence Libman and Sacks then published a case series of infection.9 Although uncommon, NBTE has of four patients in 1924 which associated these been reported in rheumatoid arthritis.8 10 There are atypical lesions with systemic lupus erythema- 2 isolated case reports of NBTE associated with rarer tosus (SLE). These vegetations are not associated copyright. autoimmune conditions, including granulomatosis with an inflammatory response or bacteraemia http://heart.bmj.com/ with polyangiitis, Behçet’s disease and adult- onset and commonly occur as a result of fibrin deposi- Still‘s disease.11 12 Post- mortem studies have also tion and platelet aggregation. Sterile vegetations identified NBTE in patients with HIV, although the can develop in a number of conditions, including incidence is lower than initially thought.13 autoimmune disease, malignancy and hypercoagu- NBTE is common in neoplastic conditions with lable states. Although Libman–Sacks endocarditis one prospective study reporting a prevalence of refers specifically to NBTE seen in patients with 19% in patients with underlying malignancy (most the autoimmune disorders SLE and antiphospho- frequently adenocarcinomas, particularly of the on June 11, 2020 at Inst Aragones de Ciencias la Salude. Protected by lipid syndrome (APLS), other interchangeable pancreas and lung).6 7 14–16 terminology for NBTE includes verrucous endo- Coagulation abnormalities indicative of dissem- carditis and marantic endocarditis. inated intravascular coagulation (DIC) have also A vegetation is defined as an oscillating intra- been found in up to 50% of patients with NBTE, cardiac mass on a valve (or its supporting struc- suggesting a strong relation with hypercoagu- ture) or implanted material. The rapid evolution lable states, including primary APLS, burns and of echocardiographic imaging techniques has sepsis.15–17 resulted in higher rates of vegetation detection Table 1 summarises the conditions associated in more recent studies using these developed with NBTE and their reported prevalence. Ante- imaging modalities.3 4 mortem diagnosis is rare and NBTE is therefore often underestimated. With improved imaging EPIDEMIOLOGY modalities, there is significant variability in the NBTE is a rare condition and most commonly prevalence of NBTE reported in the literature. diagnosed at post- mortem. The exact incidence Patients often have a combination of conditions is unknown but rates of up to 3.7% have been predisposing them to NBTE (such as malignancy reported at autopsy.5 6 The incidence increases with and a hypercoagulable state). age (likely due to the association with malignancy) 6 7 © Author(s) (or their with no known gender predominance. NBTE PATHOPHYSIOLOGY employer(s)) 2020. No has a well-known association with autoimmune Deposition of sterile fibrin and platelets on the commercial re- use. See rights conditions and malignancy.6 7 In the largest study of surface of valve leaflets is the pathological hallmark and permissions. Published culture- negative endocarditis, NBTE accounted for of NBTE (figure 1). Vegetations may be microscopic by BMJ. 2.5% of cases.8 Patients with definite endocarditis or large in size with a clustered, wart-like appearance, To cite: Hurrell H, Roberts- but no underlying autoimmune or malignant condi- although diffuse leaflet thickening may develop in Thomson R, Prendergast BD. tion were more likely to have a positive serum rheu- the chronic, treated phase of the disease.18 They may Heart 2020;106:1023–1029. matoid factor compared with those with confirmed occur anywhere on the endocardial surface, with a Hurrell H, et al. Heart 2020;106:1023–1029. doi:10.1136/heartjnl-2019-315204 1023 Education in Heart Heart: first published as 10.1136/heartjnl-2019-315204 on 6 May 2020. Downloaded from The aetiology of NBTE is poorly understood Table 1 Summary of conditions associated with non- bacterial thrombotic and a number of different interacting mechanisms endocarditis and their reported prevalence (including circulating immune complexes, hyper- Conditions associated with NBTE Prevalence of NBTE coagulable states and carcinomatosis) may play a Autoimmune conditions: role, ultimately resulting in endothelial damage and Systemic lupus erythematosus 4%–43% exposure of the subendothelial connective tissue to Antiphospholipid syndrome (primary and 41% circulating platelets (figure 2). secondary) Rheumatoid arthritis Unknown Immune mechanisms Granulomatous with polyangitis Single case report Pathophysiological studies in patients with SLE Behcet’s Single case report have demonstrated deposition of immunoglobulins HIV Unknown and complement complexes along the edges of valve Malignancy: 19% leaflets and within valvular vegetations, suggesting Most frequently adenocarcinomas 62% of patients with malignancy and NBTE a major pathogenic role of immune complexes in 20 21 P ancreatic cancer most common 25%–50% of patients with malignancy and NBTE mediating valvular tissue injury. Patients with Lung caner 25%–30% of patients with malignancy and NBTE SLE and secondary APLS have a similar prevalence Hypercoagulable states: Found in up to 50% of valvular involvement to those with SLE alone and no detectable anticardiolipin antibodies.19 NBTE APLS (primary and secondary APLS) may also occur (though less commonly) in patients Malignancy with primary APLS. Although it was originally Disseminated intravascular coagulopathy thought that APLS promoted a hypercoagulable Sepsis state with thrombus formation and NBTE, it is now Burns recognised that it may also mediate valve damage APLS, antiphospholipid syndrome; NBTE, non- bacterial thrombotic endocarditis. by direct immune- mediated reactions. Patients with APLS and valve involvement have higher circulating levels of anticardiolipin antibodies directed against 5 12 19 predilection for the left- sided heart valves. Poten- negatively charged phospholipids present in endo- tial mechanisms include the combination of sheer thelial cell membranes.21–23 stress on the mitral valve arising from turbulent flow and oxidative stress compared with low pressure flow copyright. of de- oxygenated blood in the right heart. Unlike Hypercoagulable states Impaired antithrombotic mechanisms in patients http://heart.bmj.com/ conventional infective endocarditis, these vegetations with APLS, malignancy and hypercoagulable are not associated with inflammation or bacteraemia. states are implicated in the pathogenesis of throm- The valves are usually previously undamaged but bosis and subsequent valve lesions. The instigating NBTE can also arise in patients with pre-existing 7 factor is unknown but it is likely that endothelial valve disease. damage provides the foundation for deposition of In infective endocarditis, underlying damage to platelets and fibrin in an already prothrombotic the valve endothelium through trauma or other state. on June 11, 2020 at Inst Aragones de Ciencias la Salude. Protected by phenomena is frequent. Bacteria then adhere to In addition to APLS, there is an association this damaged endothelium and propagate, resulting between patients with coagulation abnormalities in formation of a vegetation that promotes activa- suggestive of DIC and NBTE. In one study, 50% tion of the clotting cascade with fibrin and platelet of patients with DIC were found to have NBTE, deposition over the clusters of bacteria. In turn, this supporting the view that these conditions are often leads to valve destruction and failure, which related and result from a hypercoagulable state.17 is rare in NBTE. Figure 1 (A) Histological section of the mitral valve showing thrombotic vegetations devoid of inflammation (Brock MA et al40). (B)
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