Advances in Down Syndrome Research Series: Journal of Neural Transmission

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springer.com Gert Lubec (Ed.) Advances in Down Syndrome Research Series: Journal of Neural Transmission. Supplementa "Advances in Down Syndrome Research” represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded 2003, X, 242 p. 29 illus. structures including transcription factors are indeed overexpressed although findings in fetal DS are different from those in adult DS brain when Alzheimer-like neuropathology supervenes. Printed book Hardcover 159,99 € | £139.99 | $199.99 [1]171,19 € (D) | 175,99 € (A) | CHF 189,00 Softcover 139,99 € | £119.99 | $169.99 [1]149,79 € (D) | 153,99 € (A) | CHF 165,50 eBook 117,69 € | £95.50 | $129.00 [2]117,69 € (D) | 117,69 € (A) | CHF 132,00 Available from your library or springer.com/shop MyCopy [3] Printed eBook for just € | $ 24.99 springer.com/mycopy Order online at springer.com / or for the Americas call (toll free) 1-800-SPRINGER / or email us at: [email protected]. / For outside the Americas call +49 (0) 6221-345-4301 / or email us at: [email protected]. The first € price and the £ and $ price are net prices, subject to local VAT. Prices indicated with [1] include VAT for books; the €(D) includes 7% for Germany, the €(A) includes 10% for Austria. Prices indicated with [2] include VAT for electronic products; 19% for Germany, 20% for Austria. All prices exclusive of carriage charges. Prices and other details are subject to change without notice. All errors and omissions excepted. [3] No discount for MyCopy. Part of .

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Dynamics of Plasma Biomarkers in Down Syndrome: the Relative Levels of Aβ42 Decrease with Age, Whereas NT1 Tau and Nfl Increase
Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase David Mengel University of Tuebingen Wen Liu Brigham and Women's Hospital Robert J. Glynn Brigham and Women's Hospital Dennis J. Selkoe Brigham and Women's Hospital Andre Strydom King's College London Florence Lai Massachusetts General Hospital H. Diana Rosas Massachusetts General Hospital Amy Torres Massachusetts General Hospital Vasiliki Patsiogiannis Massachusetts General Hospital Brian Skotko Massachusetts General Hospital Dominic Walsh ( [email protected] ) Brigham and Women's Hospital and Harvard Medical School Research Keywords: Alzheimer’s disease, amyloid, Down syndrome, dementia, neurolament light, Simoa Posted Date: January 29th, 2020 DOI: https://doi.org/10.21203/rs.2.18106/v2 Page 1/23 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Version of Record: A version of this preprint was published at Alzheimer's Research and Therapy on March 19th, 2020. See the published version at https://doi.org/10.1186/s13195-020-00593-7. Page 2/23 Abstract Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s Disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS. When disease-modifying agents for AD are approved, reliable biomarkers will be required to identify when and how long people with DS should undergo treatment. Three cardinal neuropathological features characterize AD, and AD in DS – Aβ amyloid plaques, tau neurobrillary tangles, and neuronal loss. Here, we quantied plasma biomarkers of all 3 neuropathological features in a large cohort of people with DS aged from 3 months to 68 years.
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Modelling Down Syndrome
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(12) United States Patent (10) Patent N0.: US 7,285,526 B2 Maroun (45) Date of Patent: Oct
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