Scientific Program

ICFTD 2016 Program August 31, 2016

Scientific Program

10th International Conference on Frontotemporal Dementias

August 31–September 2, 2016 Munich (GERMANY)

1 www.icftd2016.de ICFTD 2016 Program August 31, 2016

12:15–12:30 Opening Room Lecture Hall Chairs Janine Diehl-Schmid (Munich/DE), Manuela Neumann (Tuebingen/DE)

12:30–13:50 Session 1: FTLD: current perspectives - future directions Room Lecture Hall Chairs Bruce Miller (San Francisco, CA/US), Julie Snowden (Manchester/GB)

12:30 Changing perspectives on frontotemporal dementia Julie Snowden (Manchester/GB)

12:55 Frontotemporal dementia neuroanatomy: onset, spread, and implications for treatment William S. Seeley (San Francisco, CA/US)

13:20 Social and Economic Burden of Frontotemporal Degeneration O1 James Galvin (Boca Raton/US), David Howard (Atlanta/US), Nadine Tatton, Sharon Denny (Radnor/US)

13:35 Toward tau PET imaging in FTLD: An update O2 Brad Dickerson, Scott McGinnis, Sara Makaretz, Christina Caso, Aaron Schultz, Keith Johnson (Charlestown/US)

14:20–15:55 Session 2: Social cognition and behavior: challenges and interventions Room Lecture Hall Chairs Adrian Danek (Munich/DE), Mario Mendez (Los Angeles, CA/US)

14:20 Current concepts of social cognition and assessment in FTD Bruno Dubois (Paris/FR)

14:45 Empathy and emotional processing in FTD Katherine Rankin (San Francisco, CA/US)

15:10 An analysis of the trajectories of illness severity measurements in behavioral variant frontotemporal dementia O3 Kalyani Kansal, Halima Amjad, Sadhvi Saxena, Chiadi Onyike (Baltimore/US)

15:25 Phenotype, neuropsychology and psychopathology of C9orf72 mutation carriers from the German FTLD-Consortium O4 Janine Diehl-Schmid, Carola Rossmeier (Munich/DE), Sarah Straub, Theresia Kelm (Ulm/DE), Johannes Kornhuber (Erlangen/DE), Klaus Fliessbach (Bonn/DE), Timo Grimmer (Munich/DE), Alexander Kehl, Markus Otto (Ulm/DE), Matthias L. Schroeter (Leipzig/DE), German FTLD-Consortium (Ulm/DE)

15:40 Reward deficits in behavioral variant frontotemporal dementia include insensitivity to negative stimuli DB1 David Perry, Samir Datta, Virginia Sturm, Kristie Wood, Jessica Zakrzewski, Bruce Miller, Joel Kramer, Howard Rosen (San Francisco, CA/US)

ICFTD 2016 Program August 31, 2016

15:42 Embodied Cognition of Dynamic Emotion in Frontotemporal Lobar Degeneration DB2 Charles Marshall, Chris Hardy, Lucy Russell, Camilla Clark, Katrina Dick, Emilie Brotherhood, Jennifer Nicholas, Jonathan Rohrer, James Kilner, Jason Warren (London/GB)

15:44 Longitudinal decline in cognitive functioning in presymptomatic frontotemporal dementia DB3 Janne Papma, Lize Jiskoot, Elise Dopper, Tom Den Heijer, Reinier Timman, Rick Van Minkelen, John Van Swieten (Rotterdam/NL)

15:46 The impact of context on emotion decoding in frontotemporal dementia DB4 Fiona Kumfor (Randwick, Sydney, Sydney/AU), Agustin Ibañez (Buenos Aires, Santiago/AR), John Hodges, Olivier Piguet (Randwick, Sydney, Sydney/AU)

15:48 Neuropsychological profiles in behavioural variant Frontotemporal Dementia and Psychiatric disorders DB5 Everard Vijverberg (Amsterdam, The Hague/NL), Sigfried Schouws, Paul David Meesters, Sietske Sikkes (Amsterdam/NL), Esmee Verwijk (The Hague/NL), Hannie Comijs, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)

15:50 Frontotemporal Dementia in Patients of African Descent DB6 Keith Josephs (Rochester/US), William Hu (Atlanta/US), Argye Hillis (Baltimore/US), Bradley Dickerson (Boston/US), Neill Graff-Radford (Jacksonville/US), Cameron Davis (Baltimore/US), Rufus Akinyemi, Adesola Ogunniyi (Ibadan/NG), Nilufer Taner (Jacksonville/US), Jonathan Graff-Radford (Rochester/US), Amza Ali (Mona/JM), David Tang-Wai (Toronto/CA), Meredith Wicklund (Gainesville/US), Florence Pasquier, Florence Lebert (Lille/FR), Julie Snowden (Manchester/GB), Nick Fox (London/GB), Murray Grossman (Philadelphia/US), Chiadi Onyike (Baltimore/US)

15:55–17:30 Postersession I - Caregiver Room Ballroom

P35 Spouses' experience of behavioural-variant frontotemporal dementia in the pre- diagnostic phase Kirrily Rogers (Parkville/AU), Amy Brodtmann, David Darby (Heidelberg, Box Hill/AU), Vicki Anderson (Parkville/AU)

P36 Emotional Behavior in Dementia Patients and Spousal Caregivers: Rrelationship with Caregiver Depression Alice Verstaen, Anna Sapozhnikova, Sandy Lwi, Marcela Otero, Casey Brown, Dyan Connelly, Robert Levenson (Berkeley/US)

P37 The Marte Meo-concept as a useful tool in understanding and counseling in FTD Ursula Becker (Alfter/DE)

P38 Do neuropsychiatric symptoms lead to nursing home placement in bvFTD? Differences and similarities between community and nursing home residents Clarissa Giebel (Manchester/GB), Rachel Winson (Norwich/GB), David Knopman (Rochester/US), Eneida Mioshi (Norwich/GB)

P39 Dimensions and Predictors of Perceived Burden Among Caregivers of Patients with Frontotemporal Degeneration James Galvin (Boca Raton/US)

ICFTD 2016 Program August 31, 2016

P40 Unity with Creativity: A new model to leverage rare disease advocacy organization expertise into high-quality local support for FTD caregivers Sharon Denny, Bridget Moran (Radnor/US)

P41 Characteristics of caregiver burden among mild frontotemporal lobar degeneration patients: comparison between behavioral variant frontotemporal dementia and semantic dementia with right- and left-sided predominant cerebral atrophy. Asuka Koyama, Ryuji Fukuhara, Yusuke Miyagawa, Maki Hotta, Mamoru Hashimoto, Manabu Ikeda (Kumamoto/JP)

P42 Family experiences of living with behavioural variant Frontotemporal Dementia (bvFTD): implications of a qualitative longitudinal research study for coping and interventions Jan Oyebode, Jenny LaFontaine (Bradford/GB), Michael Larkin (Birmingham/GB)

P43 An intervention program for caregivers of early-onset dementia patients with frontal behavioral changes: an explorative study increasing their sense of competence Flora Gossink, Yolande Pijnenburg, Philip Scheltens, Rikie Kleverwal, Aafke Pera, Nicole Korten, Max Stek, Rose-Marie Droes, Annemiek Dols (Amsterdam/NL)

P44 Family repercussions as a consequence of the alterations of social cognition present in a patient diagnosed with frontotemporal dementia - behavioral variant Daniel Martinez Martinez, Delver Amaury Garzón Muñoz, Johana Andrea Ramírez Torres, Adelaida Bedoya Salcedo, Milena García García (Bogotá/CO)

P45 Care for people with Young Onset Dementia: A web-based intervention aiming to support family carers Susanna Saxl, Helga Schneider-Schelte (Berlin/DE)

P46 Caregivers' Attitudes Toward Family Participation in Frontotemporal Degeneration Biomarker Research Courtney Igne (Philadelphia/US), Lauren Massimo (University Park, PA/US), Corey McMillan, Rachael Langey, Collin York, Kim Firn, Olga Kofman, Amy Halpin, Murray Grossman (Philadelphia/US)

P47 Service needs in Young Onset Dementia: How ‘closest’ relatives balance being a carer, being a care manager and meeting their own needs. Jan Oyebode (Bradford/GB), Bridget Jones (Guildford/GB), Heather Blakey (Leeds/GB), Sahdia Parveen (Bradford/GB), Christian Bakker (Nijmegen/NL), Joany Millenaar, Marjolein de Vugt (Maastricht/NL), Alexander Kurz (Munich/DE), Heather Gage (Guildford/GB)

P48 The CARE Pathway Model for Dementia: Integrating Psychosocial and Rehabilitative Strategies for Care of Persons with FTD Disorders Darby Morhardt, Sandra Weintraub, Becky Khayum, Emily Rogalski, Marsel Mesulam (Chicago/US)

P49 Dissociation of Clinical Diagnostic and Caregiver Distress Neuropsychiatric Features in FTD Lydia Hatfield, Jennifer Wynne Taylor, Matthew Harris, Nansi Greger-Holt, Daniel I. Kaufer (Chapel Hill/US)

ICFTD 2016 Program August 31, 2016

15:55–17:30 Postersession I - Social cognition and behavior Room Ballroom

P50 In extremis: decision-making deficit in behavioral variant frontotemporal dementia Guilhem Carle, Nicolas Borderies, Carole Azuar, Aurélie Guignebert, Maeva Camus, Goeffroy Gagliardi, Raphael Le Bouc, Richard Levy, Mathias Pessiglione (Paris/FR)

P51 Moral judgments in frontotemporal dementia Ingo Uttner, Lukas Petersdorff, Sarah Anderl-Straub, Elisa Semler, Sarah Böhm, Dorothée Lulé (Ulm/DE), Heiner Fangerau (Düsseldorf/DE), Markus Otto (Ulm/DE)

P52 Cross frequency coupling during response inhibition in behavioural variant frontotemporal dementia Laura Hughes, James Rowe (Cambridge/GB)

P53 Prolonged Visual Facial Gaze in Frontotemporal Dementia Pongsatorn Paholpak (Khon Kaen, Los Angeles/TH), Liang Li-Jung, Drew R. Carr, Elvira Jimenez, Robin J Barrows, Valeiry Sabodash, Mario F. Mendez (Los Angeles/US)

P54 Person-Based vs. Generalized Impulsivity Disinhibition in Frontotemporal Dementia and Alzheimer’s Disease Pongsatorn Paholpak (Khon Kaen, Los Angeles/TH), Drew R. Carr, Joseph P Barsuglia, Robin J Barrows, Elvira Jimenez (Los Angeles/US), Grace J Lee (Loma Linda/US), Mario F. Mendez (Los Angeles/US)

P55 Emotion and Moral Dilemmas in Behavioral Variant Frontotemporal Dementia Sylvia S. Fong (Los Angeles/US), Carlos D. Navarrete (East Lansing/US), Sean E. Perfecto, Andrew R. Carr, Elvira E. Jimenez, Mario F. Mendez (Los Angeles/US)

P56 The pitfall of behavioral variant frontotemporal dementia mimics despite multidisciplinary application of the FTDC criteria Welmoed Krudop, Annemiek Dols, Cora Kerssens, Piet Eikelenboom, Niels Prins, Christiane Möller, Siegfried Schouws, Didi Rhebergen, Eric Exel, van, Wiesje Flier, van der, Sietske Sikkes, Philip Scheltens, Max Stek (Amsterdam/NL)

P57 Neuropsychiatric effects of neurodegeneration of the medial versus lateral ventral prefrontal cortex in humans Edward Huey, Seonjoo Lee, Adam Brickman, Masood Manoochehri, Erica Griffith, D.P. Devanand, Yaakov Stern (New York, NY/US), Jordan Grafman (Chicago, IL/US)

P58 Combined intensity ratings of congruent and incongruent facial emotions highly discriminate between behavioral-variant frontotemporal dementia and major depressive disorder Isabelle Chiu (Basel/CH), Olivier Piguet (Sydney/AU), Janine Diehl-Schmid, Lina Riedl (Munich/DE), Johannes Beck, Thomas Leyhe, Edith Holsboer-Trachsler (Basel/CH), Manfred Berres (Koblenz/DE), Andreas U. Monsch, Marc Sollberger (Basel/CH)

P59 Executive functioning and mental attribution predict environmentally-driven behaviours in behavioural variant frontotemporal dementia Emma Flanagan (Norwich/GB), Maxime Bertoux (Norwich, Paris/GB), Bruno Dubois, Valérie Hahn, Elodie Guichart-Gomez (Paris/FR), Eneida Mioshi (Norwich/GB), Marie Sarazin (Paris/FR), Michael Hornberger (Norwich/GB)

ICFTD 2016 Program August 31, 2016

P60 Emotion recognition in presymptomatic CHMP2B mutation carriers Jette Stokholm, Peter Roos, Jørgen E. Nielsen (Copenhagen/DK), Adrian M. Isaacs (London/GB), Jerry Brown (Cambridge/GB), Peter Johannsen (Copenhagen/DK)

P61 Emotion network breakdown relates to baseline autonomic dysfunction in behavioral variant frontotemporal dementia Virginia Sturm, Jesse Brown, Alice Hua, Sandy Lwi, Howard Rosen, Bruce Miller, Robert Levenson, William Seeley (San Francisco/US)

P62 The Eating Behavior Inventory (EBI): a new clinical tool for the early diagnosis of frontotemporal dementia. Carole Azuar, Adriana Amaya, Maeva Camus, Aurelie Funkiewiez, Thomas Mauras, Richard Levy, Isabelle Le Ber, Bruno Dubois (Paris/FR)

P63 Clinical types of FТD in elderly patients of Alzheimer’s disease outpatients clinic (clinical-neuropsychological study) Yana Fedorova, Irina Roshchina, Elena Ponomareva, Igor Kolykhalov, Natalia Mikhаylova, Svetlana Gavrilova (Moscow/RU)

P64 Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia Jan Jastorff, François-Laurent De Winter, Jan Van Den Stock, Mathieu Vandenbulcke (Leuven/BE)

P65 Determinants of theory of mind performance in Alzheimer's disease Siddharth Ramanan (Bangalore/IN), Leonardo Cruz de Souza (Belo Horizonte/BR), Marie Sarazin (Paris/FR), Antonio Lúcio Teixeira, Paulo Caramelli (Belo Horizonte/BR), Bruno Dubois (Paris/FR), Michael Hornberger, Maxime Bertoux (Norwich/GB)

P66 Brain structural correlates of executive and social cognition profiles in behavioral variant Frontotemporal Dementia and elderly Bipolar Disorder Teresa Torralva, Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira Cordero (BUenos Aires/AR), Agustin Ibañez, Indira Cordero (Buenos Aires/AR), Cruz Francy, Pablo Reyes, Diana Matellana (Bogota/CO), Marcelo Cetkovich, Facundo Manes (Buenos Aires/AR)

P67 Uncovering the neural bases of cognitive and affective empathy loss in the behavioural-variant of frontotemporal dementia Muireann Irish, Nadene Dermody, Stephanie Wong, John Hodges, Olivier Piguet (Sydney/AU)

P68 Multimodal evidence of interoceptive dimensions in neurodegeneration and stroke Indira García-Cordero, Lucas Sedeño, Teresa Torralva, Laura de la Fuente, Jessica Ferrari, Clara Rodriguez, Sandra Baez, Adrian Yoris, Sol Esteves, Margherita Melloni, Paula Salamone, Facundo Manes, Adolfo Garcia, Agustin Ibañez (Buenos Aires/AR)

P69 Bilingualism effect on cognitive development in Mongolian children Delgertsetseg Chuluundorj, Nyamsuren Dorjpalam, Chuluundorj Begz (Ulaanbaatar/MN)

P70 Multidimensional Apathy and Insight in Frontotemporal Lobar Degeneration and Alzheimer’s Disease

ICFTD 2016 Program August 31, 2016

Ratko Radakovic, Shuna Colville, Denise Cranley, John Starr, Suvankar Pal, Sharon Abrahams (Edinburgh/GB)

P71 Do you have a strategy? Multimodal signatures of social bargaining in neurodegeneration and frontal lesion Margherita Melloni, Teresa Torralva (BUenos Aires/AR), Pablo Billeke (Santiago/CL), Sandra Baez, Eugenia Hesse, Laura de La Fuente, Agustina Birba, Indira Garcia Cordero, Adolfo Garcia, Lucas Sedeño, Facundo Manes, Agustin Ibañez (BUenos Aires/AR)

P72 Changing the artistic experience in Behavioral variant of Frontotemporal Dementia Claire Boutoleau-Bretonniere (Nantes, Bron/FR), Cédric Bretonnière, Christelle Evrard, Laetitia Rocher (Nantes/FR), Audric Mazzietti, Olivier Koenig (Bron/FR), Martine Vercelletto, Pascal Derkinderen (Nantes/FR), Catherine Thomas-Antérion (Bron, Lyon/FR)

P73 Distinct neuropsychiatric subtypes of behavioural variant FTD have different functional profiles Claire M O'Connor, Lindy Clemson, Cassandra Kaizik, Naomi Daveson, John R Hodges, Sharpley Hsieh, Olivier Piguet (Sydney/AU), Eneida Mioshi (Norwich/GB)

P74 Neural basis of motivational approach and withdrawal behaviors in neurodegenerative disease Shunichiro Shinagawa (Tokyo, San Francisco/JP), Adhimoolam Babu, Virginia Sturm, Tal Shany-Ur, Parnian Toofanian Ross, Pardis Poorzand, Scott Grossman, Bruce Miller, Katherine Rankin (San Francisco/US)

P75 Categorization impairment in bvFTD, PSP and AD Béatrice Garcin, Emmanuelle Volle, Aurelie Funkiewiez, Nicolas Defoor, Bruno Dubois, Richard Levy (Paris/FR)

P76 So close yet so far: executive contribution to memory processing in behavioural variant frontotemporal dementia Maxime Bertoux (Norwich/GB), Siddharth Ramanan (Bangalore, India./IN), Andrea Slachevsky, Carolina Delgado, Fernando Henriquez, Gada Musa (Santiago, Chile/CL), Foudil Lamari (Paris, France/FR), Michel Bottlaender (Saclay, France/FR), Marie Sarazin (Paris, France/FR), Michael Hornberger (Norwich/GB), Bruno Dubois (Paris, France/FR)

P77 Apathy and Impulsivity in Frontotemporal Lobar Degeneration Syndromes. Claire Lansdall, Ian T.S. Coyle-Gilchrist, Patricia Vázquez Rodríguez (Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox (Cambridge/GB), Katrina M. Dick (London/GB), P. Simon Jones, Karalyn Patterson, James B Rowe (Cambridge/GB)

P78 Fronto-striatal correlates of behavioural disturbances in behavioural-variant frontotemporal dementia Maxime Bertoux, Emma Flanagan (Norwich/GB), Olivier Piguet, John Hodges (Sydney, Australia/AU), Michael Hornberger (Norwich/GB)

P79 The Brain Network Abnormalities Underlying Apathy and Impulsivity in Frontotemporal Lobar Degeneration. Claire Lansdall, Ian T.S. Coyle-Gilchrist, Patricia Vázquez Rodríguez (Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox (Cambridge/GB), Katrina M. Dick (London/GB), P. Simon Jones, Karalyn Patterson, James B. Rowe (Cambridge/GB)

ICFTD 2016 Program August 31, 2016

P80 Loss of White Matter Connectivity Related to Apathy and Impulsivity in Frontotemporal Lobar Degeneration Disorders. Claire Lansdall, Ian T.S. Coyle-Gilchrist, Patricia Vázquez Rodríguez (Cambridge/GB), Eileen Wehmann (Hamburg, Germany./DE), Alicia Wilcox, P. Simon Jones, Karalyn Patterson, James B. Rowe (Cambridge/GB)

P81 Cognitive profile in the C9ORF72 expansion related frontotemporal lobar degeneration Noora-Maria Suhonen (Oulu/FI), Ramona M Haanpää, Tuomo Hänninen, Anne M Remes (Kuopio/FI)

P82 Frontotemporal dysfunction in elderly patients with bipolar disorder Yaroslav Kalyn, Elena Shipilova, Irina Roshchina, Yana Vologdina, Tatiana Safarova (Moscow/RU)

P83 Looking but not seeing: Understanding emotional face perception in behavioural- variant frontotemporal dementia Rosalind Hutchings (Randwick/AU), Romina Palermo (Crawley/AU), Jason Bruggemann (Kensington/AU), John Hodges, Olivier Piguet, Fiona Kumfor (Randwick/AU)

P84 Should I trust you? Learning and memory of socially relevant information in dementia Stephanie Wong (Randwick/AU), Claire O'Callaghan (Cambridge/AU), Fiona Kumfor (Randwick/AU), Greg Savage (Sydney/AU), John Hodges, Olivier Piguet (Randwick/AU), Michael Hornberger (Norwich/GB)

P85 Motivated to remember? Modulation of value-based learning and memory in dementia Stephanie Wong (Randwick/AU), Greg Savage (Sydney/AU), John Hodges, Olivier Piguet (Randwick/AU), Michael Hornberger (Norwich/GB)

P86 The Awareness of Social Inference Test (TASIT): Application of a short version of the TASIT for the clinical diagnosis of behavioural-variant frontotemporal dementia Fiona Kumfor (Randwick, Sydney, Sydney/AU), Cynthia Honan (Launceston/AU), Jessica Hazelton (Randwick, Sydney/AU), John R. Hodges (Randwick, Sydney, Sydney/AU), Skye McDonald (Sydney/AU), Olivier Piguet (Randwick, Sydney, Sydney/AU)

P87 Changes in sexual behaviour and intimacy in frontotemporal dementia: impact on spousal carers. Cassandra Kaizik (Randwick/AU), Rebekah Ahmed (Randwick, Sydney/AU), Claire O'Connor (Sydney/AU), Eneida Mioshi (Norwich/GB), Olivier Piguet, John Hodges (Randwick, Sydney/AU)

P88 Neurodegeneration With Brain Iron Accumulation Can Mimic Frontotemporal Dementia Ahmet Evlice, Hacer Bozdemir, Kezban Aslan (Adana/TR)

P89 Behavioral variant frontotemporal dementia can be conceptualized and individually predicted with meta-analyses & pattern classification of imaging data Matthias Schroeter, Sebastian Meyer, Jane Neumann (Leipzig/DE), Angela Laird (Leipzig/US), Karsten Mueller, Markus Otto (Leipzig/DE)

ICFTD 2016 Program August 31, 2016

P90 Neural correlates of verbal and nonverbal memory for item-item and item-location information: Evidence from semantic dementia and Alzheimer's disease Marshall Dalton (Sydney, Australia, London, UK/AU), Michael Hornberger , John Hodges, Olivier Piguet (Sydney, Australia/AU)

P91 A spatial anticipation deficit is revealed by eyetracking metrics in behavioural variant frontotemporal dementia. Silvia Primativo, Camilla Clark, Keir Yong, Jason Warren, Jonathan Rohrer, Sebastian Crutch (London/GB)

P92 Autonomic and Facial Expressive Emotional Responses: Relationships with Disease Severity and Frontotemporal Dementia Subtypes Alice Hua, Sandy Lwi (Berkeley/US), Bruce Miller (San Francisco/US), Robert Levenson (Berkeley/US)

P93 Processing of auditory conflict in frontotemporal dementia Camilla Clark, Jennifer Agustus, Jennifer Nicholas, Chris Hardy, Catherine Mummery, Jonathan Schott, Jonathan Rohrer, Sebastian Crutch, Jason Warren (London/GB)

P94 Expectation and reward in frontotemporal dementia: the case of music Camilla Clark, Hannah Golden, Oliver McCallion, Jennifer Nicholas, Miriam Cohen, Catherine Slattery, Ross Paterson, Alexander Foulkes, Catherine Mummery, Jonathan Schott, Jonathan Rohrer, Sebastian Crutch, Jason Warren (London/GB)

P95 Longitudinal profiles of autobiographical memory retrieval in FTD Annu Mothakunnel, Sharpley Hsieh, Ramon Landin-Romero, John R. Hodges, Olivier Piguet, Muireann Irish (Sydney/AU)

P96 PERSONAL SPACE IN FRONTOTEMPORAL DEMENTIA Sarah Anderl-Straub, Magdalena Nagl, Jens Dreyhaupt, Hans-Peter Müller, Markus Otto, Ingo Uttner (Ulm/DE)

P97 All is not lost: Positive behaviors in Alzheimer’s disease and behavioral-variant frontotemporal dementia with disease severity Akira Midorikawa (Hachioji-shi, Sydney/JP), Cristian Leyton, David Foxe, Ramon Landin-Romero, John Hodges, Olivier Piguet (Sydney/AU)

P98 Clinical Differentiation of Psychiatric Disorders from Behavioural Variant Frontotemporal Dementia: A prospective study Everard Vijverberg (Amsterdam, The Hague/NL), Flora Gossink, Welmoed Krudop, Sietske Sikkes, Cora Kerssens, Niels Prins, Max Stek, Philip Scheltens, Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)

P99 Music defines fMRI signatures of molecular nexopathies Jennifer L Agustus, Camilla N Clark, Hannah L Golden, Catherine F Slattery, Phillip D Fletcher, Jonathan D Rohrer, Jason D Warren (London/GB)

P100 Do criteria for behavioural variant frontotemporal dementia capture the cognitive and behavioural profile of ALS/FTD? Jennifer Adams, Jennifer Thompson, Matthew Jones, Jennifer Harris, Anna Richardson, Tobias Langheinrich, David Neary, Julie Snowden (Salford/GB)

P101 Progression in late onset frontal lobe syndrome Flora Gossink, Everard Vijverberg, Welmoed Krudop, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)

ICFTD 2016 Program August 31, 2016

P102 Body schema processing in frontotemporal dementia Rebecca Bond, Christopher Hardy, Lucy Russell, Charles Marshall, Camilla Clark, Sebastian Crutch, Jonathan Rohrer, Jason Warren (London/GB)

P103 Vascular Frontotemporal Disorder Michael Hoffmann, Fabian Rossi, Ramon Rodriguez Cruz, Annuli Khaki, Khizar Malik (Orlando, Florida, Orlando/US)

P104 Risk of suicide in patients with behavioral variant Frontotemporal Dementia Innocenzo Rainero, Milena Zucca, Elisa Rubino, Flora Govone, Alessandro Vacca, Lorenzo Pinessi (Turin/IT)

P105 Moral processing deficit in behavioral variant frontotemporal dementia is associated with emotion recognition deficits and both structural and functional lateral orbitofrontal abnormalities Jan Van den Stock, François-Laurent De Winter, Dante Mantini, Jan Jastorff, Rik Vandenberghe, Mathieu Vandenbulcke (Leuven/BE)

P106 Demographic influence in Depression prevalence in frontotemporal dementia (FTD): A meta-regression perspective Amir Sepehry, Anita Afshinkia, Ging-Yuek Robin Hsiung (Vancouver/CA)

P107 Boxer’s Dementia with Aggression and Sexual Disinhibition - A Case Series Viviana Chiappetta, Mohamed Eldefrawi, Sasidhar Gunturu, Monica Babillo, Marlene Carrillo, Elba Contreras (Bronx/US)

P108 Psychotic symptoms and formal thought disorders in behavioral variant frontotemporal dementia Flora Gossink, Everard Vijverberg, Welmoed Krudop, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemiek Dols (Amsterdam/NL)

P109 Profile of Memory impairment in behavioral variant of the FTD Milena Garcia Garcia, Cristian Triviño Martinez, José Manuel Santacruz Escudero, Diana Lucía Matallana Eslava (Bogotá/CO)

P110 Semantic categorization into the variants of FTD Cristian Triviño Martínez, Milena García García, Hernando Santamaría-García, Diana Lucía Matallana Eslava (Bogotá/CO)

P111 A longitudinal study of neuropsychiatric and cognitive symptoms in patients with FTDbv Milena Garcia Garcia, Cristian Triviño Martinez, José Manuel Santacruz Escudero, Diana Lucía Matallana Eslava (Bogotá/CO)

P112 Differences in social cognition between behavioral-variant frontotemporal dementia and depression: preliminary results Maya Lichtenstein, Nader Fallah, Andrew Howard (Vancouver/CA), Paul Eslinger (Hershey/US), Howard Feldman (Vancouver, San Diego/US)

P113 Behavioral variant frontotemporal dementia mimicked by right carotid artery stenosis without observable lesion on MRI. Yong Bum Kim, Pil-Wook Chung, Heui-Soo Moon, Bum Chun Suh, Won Tae Yoon (Seoul/KR)

ICFTD 2016 Program August 31, 2016

P114 Neuropsychological Assessment of Medial Frontal Functioning in Frontotemporal Dementia Julia MacKinley, Mervin Blair, Kristy Coleman, Sascha Gill, Dhwanil Bhatty (London/CA), Erin Warriner, Kathy Smolewska (Hamilton/CA), Stephen Pasternak (London/CA), Mavis Kershaw (Victoria/AU), Elizabeth Finger (London/CA)

P115 Neural Correlates of Reversal Learning Deficits in Behavioral Variant Frontotemporal Degeneration Kylie Ternes, Joseph Kable (Philadelphia/US), Joseph McGuire (Boston/US), Katya Rascovsky, Corey McMillan, Murray Grossman (Philadelphia/US)

P116 Compulsory mental care among patients with a neuropathologically confirmed dementing disorder Madeleine Liljegren, Maria Landqvist Waldö, Robert Rydbeck, Elisabet Englund (Lund/SE)

P117 Qualitative assessment of verbal fluency performance in patients with bvFTD and PPA Esther van den Berg, Lize Jiskoot, Marielle Grosveld, John van Swieten (Rotterdam/NL)

P118 Similar Findings on Clinical and Neuropsychological Measures in Asymptomatic Mutation Versus Non-Mutation Carriers: Preliminary Data From LEFFTDS Brad Boeve (Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US), Brad Dickerson (Boston/US), Kelley Faber (Indianapolis/US), Julie Fields (Rochester/US), Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao (Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San Francisco/US), David Knopman (Rochester/US), John Kornak, Joel Kramer (San Francisco/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine Rankin (San Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US)

P119 Differences on Neuropsychiatric Measures in Asymptomatic (CDR=0) Versus Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS Howard Rosen (San Francisco/US), Brad Boeve (Rochester/US), Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US), Bradford Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields (Rochester/US), Tatiana Faroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao (Bethesda/US), Ging-Yuek R. Hsiung (Vancouver/CA), Edward D. Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San Francisco/US), David Knopman (Rochester/US), John Kornak, Joel Kramer (San Francisco/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine Rankin (San Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US),

ICFTD 2016 Program August 31, 2016

Ashley Vetor (Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US)

P120 Investigating the role of face processing in behavioural variant frontotemporal dementia Lucy Russell, Martina Bocchetta, Sophie Harding, Sebastian Crutch, Jason Warren, Jonathan Rohrer (London/GB)

P121 Neuropsychological profiles in familial frontotemporal dementia Sophie Leijdesdorff, Esther van den Berg, Lize Jiskoot, Janne Papma, John van Swieten (Rotterdam/NL)

P122 Longitudinal analysis of cognitive test score trajectories in behavior variant frontotemporal dementia Kalyani Kansal, Halima Amjad, Sadhvi Saxena, Chiadi Onyike (Baltimore/US)

P123 Social behavioral changes differ in frontotemporal dementia and semantic dementia Harmony DUCLOS, Serges BELLIARD, Catherine MERCK, Vincent DE LA SAYETTE, Francis EUSTACHE, Beatrice DESGRANGES, Mickaël LAISNEY (Caen/FR)

P124 Longitudinal analysis of electronic messages to characterize language decline in frontotemporal dementia with bulbar amyotrophic lateral sclerosis Kalyani Kansal, Elsheba Abraham, Ashnaa Rao, Chiadi Onyike (Baltimore/US)

P125 Longitudinal performance of global measures of illness severity in semantic dementia Kalyani Kansal, Halima Amjad, Sadhvi Saxena, Chiadi Onyike (Baltimore/US)

P126 Neuropsychiatric Symptoms in the Genetic Frontotemporal Dementia Initiative (GENFI) Cohort Leila Sellami (Québec/CA), Martina Bocchetta (London, United Kingdom/GB), John van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti (Milan/IT), Mario Masellis (Toronto/CA), James B Rowe (Cambridge/GB), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milano/IT), Giovanni Frisoni (Brescia/IT), Elizabeth Finger (London Ontario/CA), Alexandre Mendonça (Lisboa/PT), Sandro Sorbi (Florence/IT), Katrina M Dick, Jonathan D Rohrer (London/GB), Robert Laforce Jr (Québec/CA)

P127 Differences on Neuropsychological Measures in Asymptomatic (CDR=0) Versus Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS Joel Kramer (San Francisco/US), Sandra Weintraub (Chicago/US), Brad Boeve (Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US), Brad Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields (Rochester/US), Tationa Faroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao (Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San Francisco/US), David Knopman (Rochester/US), John Kornak (San Francisco/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine Rankin (San Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US), Zbigniew Wszolek (Jacksonville/US)

ICFTD 2016 Program August 31, 2016

P128 Depressive symptoms in patients with frontotemporal lobar degeneration Mamoru Hashimoto, Ryuji Fukuhara, Keiichiro Kaneda, Manabu Ikeda (Kumamoto/JP)

P129 Virtual reality as an assessment of cognition in behavioural variant Frontotemporal Dementia: A Feasibility Study. Emilie Brotherhood, Jason Drummond, David Swapp, Lucy Russell, Silvia Primativo, Chris Hardy, Anthony Steed, Mel Slater, Jonathan D. Rohrer, Jason Warren, Sebastian Crutch (London, UK/GB)

P130 Mistakes, I’ve made a few: Intact awareness, but impaired emotional processing of errors in bvFTD. Howard Rosen, Carole Scherllng (San Francisco/US), Jessica Zakrzewski (San Francisco, Gainsville/US), Samir Datta (San Francisco/US), Robert Levenson (Berkeley/US), Virginia Sturm, Bruce Miller (San Francisco/US)

P131 Misdiagnosis of very early frontotemporal dementia Florindo Stella (Rio Claro-SP, Brazil, São Paulo - Brazil, Campinas-SP, Brazil/BR), Lucas Mella, Vítor Marques, Thiago Fontana (Campinas-SP, Brazil/BR), Júlia Loureiro (São Paulo - Brazil, Campinas-SP, Brazil/BR), Luiz Silva (Campinas-SP, Brazil/BR)

P132 CLINICAL AND NEUROCOGNITIVE CORRELATES UNDERLYING THE FIRST SYMPTOMS IN BEHAVIORAL VARIANT OF FRONTO TEMPORAL DEMENTIA (BVFTD) Hernando Santamaría García (Bogotá, Buenos Aires/CO), Pablo Reyes (Bogotá/CO), Sandra Báez (Buenos Aires/AR), Ángela Martínez, José Santacruz (Bogotá/CO), Mariano Sigman (Buenos Aires/AR), Diana Matallana (Bogotá/CO), Agustín Ibáñez (Buenos Aires/CO)

P133 Frontotemporal dementia and schizophrenia - whats the connection I? An updated case series and review of the literature. Dennis Velakoulis, Samantha Loi (Melbourne/AU)

P134 Neuronal correlates of theory of mind and emotion comprehension during insincere communication in neurodegenerative disease Gianina Toller, Tal Shany-Ur, Suzanne Shdo, Laura Bouvet, Clinton Mielke, Scott N. Grossman, Pardis Poorzand, Bruce L. Miller, Katherine P. Rankin (San Francisco/US)

P135 Intra-individual variability in cognitive measures as a differential marker of genetic variant FTD: a neuropsychological perspective Amir Sepehry, Dana Wittenberg, Pheth Sengdy, Penny Slack (Vancouver/CA), Matt Baker, Rosa Rademakers (Jacksonville/US), Howard Feldman, Ian Mackenzie, Ging- Yuek Hsiung (Vancouver/CA)

P136 The Moral Emotions Assessment: a new tool for the early diagnosis of frontotemporal dementia. Chloe Daigmorte, Maeva Camus, Thomas Mauras, Aurélie Funkiewiez, Isabelle Le Ber, Bruno Dubois, Richard Levy, Marc Teichmann, Carole Azuar (Paris/FR)

P137 ECOCAPTURE. A Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated. Bénédicte BATRANCOURT, Karen LECOUTURIER, Carla ARAUJO (PARIS, F- 75013, Paris, France/FR), Vincent GUILLEMOT (F-75013, Paris, France/FR), Carole AZUAR, Richard LEVY (PARIS, F-75013, Paris, France/FR)

ICFTD 2016 Program August 31, 2016

P138 Physical aggressiveness among patients with a neuropathologically confirmed dementing disorder Madeleine Liljegren, Maria Landqvist Waldö (Lund/SE), Alexander Frizell Santillo (Malmö/SE), Elisabet Englund (Lund/SE)

P139 Neuropsychiatric symptoms in patients with Alzheimer's disease and frontotemporal dementia. Why is it important the night time behaviors and anxiety in the clinical presentation of the Frontolobar Degeneration dementia? Adrian Martinez Ruiz, G. Isaac Acosta Castillo, Leonardo Ramirez, Ana Luisa Sosa Ortiz (Mexico City/MX)

P140 Association between MoCA Subitem Scores and Corresponding Cognitive Test Performance in Patients with bvFTD Kristy Coleman (London/CA), Brenda Coleman (Toronto/CA), Julia MacKinley, Stephen Pasternak, Elizabeth Finger (London/CA)

P141 The differences of characteristics in abnormal eating behaviors in semantic dementia between right and left predominant temporal lobe atrophy Ryuji Fukuhara, Mamoru Hashimoto (Kumamoto-city/JP), Shunichiro Shinagawa (Tokyo/JP), Kazue Shigenobu (Osaka/JP), Hibiki Tanaka, Kazuhiro Kawahara, Yusuke Miyagawa, Naoko Ichimi, Manabu Ikeda (Kumamoto-city/JP)

P142 Relationship between cognitive declines and independency in the activities of daily living in patients with frontotemporal dementia. Maki Hotta, Mamoru Hashimoto, Ryuji Fukuhara, Asuka Koyama, Miki Murata, Kazuhiro Yoshiura, Tomohisa Ishikawa, Hibiki Tanaka, Manabu Ikeda (Kumamoto/JP)

P143 Neurobiological Subtract of False-Belief Reasoning: Insights from Frontotemporal Dementia and Alzheimer’s Disease Belen Pascual, Sahil Bajaj, Joseph C Masdeu (Houston/US)

P144 Altered Fronto-Thalamic Functional Connectivity and its Association with Emotion Recognition Deficits in Frontotemporal Dementia Namita Multani, Cassandra Jessica Anor, David F. Tang-Wai, Ron Keren, Maria Carmela Tartaglia (Toronto/CA)

P145 Frontal lobe dysfunction in early recovery period of ischemic stroke Lyudmila Pustokhanova, Elena Morozova (Perm/RU)

P146 Longitudinal neuropsychological evaluation of progranulin (GRN) mutation carriers Dana Wittenberg, Robin G.Y. Hsiung, Pheth Sengdy (Vancouver/CA), Matthew Baker, Rosa Rademakers (Vancouver/US), Penny Slack, Howard H. Feldman, Ian R. Mackenzie (Vancouver/CA)

P147 Cognitive and Behavioral Trajectory of Behavioral-Variant Frontotemporal Dementia Differs According to Underlying Pathology Jeffrey Phillips, David Irwin, Katya Rascovsky, Vivianna Van Deerlin, Virginia Lee, John Trojanowski, Corey McMillan, Murray Grossman (Philadelphia/US)

P148 Variables affecting emotional reactivity to socioemotional stimuli in frontotemporal dementia Sylvia Fong, Mario F. Mendez (Los Angeles/US)

ICFTD 2016 Program August 31, 2016

P149 Patterns of neuropsychiatric symptoms in a Mexican sample diagnosed with Alzheimer’s disease and frontotemporal dementia (behavioral and language variants) according to stage of cognitive decline. Juan Francisco Flores-Vazquez, Gilberto Isaac Acosta-Castillo, Airam Campos- Jiménez, Loreli Alvarez-Diaz, Adrian Martínez Ruiz, Ana Luisa Sosa-Ortiz (Mexico City/MX)

P150 Differences on Novel Measures of Social Comportment in Asymptomatic (CDR=0) Versus Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS Katherine Rankin, Joel Kramer, Howard Rosen (San Francisco/US), Brad Boeve (Rochester/US), Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US), Brad Dickerson (Boston/US), Christina Dheel, Julie Fields, Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao (Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas, John Kornak (San Francisco/US), David Knopman (Rochester/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US)

P151 Greater facial expressive versus self-reported emotional reactivity correlates with diminished right posterior insular volume in bvFTD Peter Pressman (San Francisco, Berkeley/US), James J. Casey, Kuan Hua-Chen (Berkeley/US), Clinton Mielke, Katherine Rankin (San Francisco/US), Robert W. Levenson (Berkeley/US)

P152 Frontotemporal dementia and schizophrenia - whats the connection II? A neuropsychological and social cognition comparison of patients with chronic schizophrenia and FTD Dennis Velakoulis, Hui-Minn Chan, Wendy Kelso, Rene Stalky (Melbourne/AU)

P153 The Attribution of Animacy and Agency in Frontotemporal Dementia vs. Alzheimer’s Disease Sylvia S Fong, Andrew R Carr, Madelaine Daianu (Los Angeles/US), Mariel B Deutsch (Los Angeles, New York/US), Elvira E Jimenez, Kevin O Juarez, Michelle M Mather (Los Angeles/US), Pongsatorn P Paholpak (Los Angeles, Khon Khaen/TH), Sean E Perfecto, Paul M Thompson, Mario F. Mendez (Los Angeles/US)

P154 Social emotions in behavioral variant frontotemporal (bvFTD) patients. How FTD patients experience schadenfreude and envy. Hernando Santamaría García (Bogotá, Buenos Aires/CO), Sandra Baez (Bogotá, Buenos Aires/AR), Pablo Reyes, Diana Matallana (Bogotá/CO), Agustín Ibáñez (Buenos Aires/CO)

P155 Cross-cultural Adaptation and Validity of the Brazilian version of the Clinical staging scale and disease progression in frontotemporal dementia Thaís Bento Lima da Silva, Valéria Bahia, Mário Amore Cecchini, Luciana Cassimiro, Viviane Amaral Carvalho, Henrique Cerqueira Guimarães, Paulo Caramelli, Marcio Balthazar, Benito Damasceno, Cássio Bottino, Sonia Brucki, Leonardo Cruz de Souza (SAO PAULO/BR), Eneida Mioshi (SAO PAULO/GB), Ricardo Nitrini, Mônica Yassuda (SAO PAULO/BR)

ICFTD 2016 Program August 31, 2016

P156 Distinct Patterns of Cognitive Behavioral Change in Emerging FTLD in the Presence and Absence of MND Support a ‘Bottom-Up’ Model of FTLD Onset. Claire Flaherty (Hershey/US)

17:30–19:00 Session 3: Genetics of FTLD Room Lecture Hall Chairs Peter Heutink (Tuebingen/DE), Christine van Broeckhoven (Antwerp/BE)

17:30 Next generation sequencing approaches in FTD and ALS Stefan Züchner (Miami, FL/US)

17:55 Identification Of A Novel FTD-MND Gene On Chromosome 16 O5 Carol Dobson-Stone, Agnes Luty (Sydney/AU), Elizabeth Thompson, Peter Blumbergs (Adelaide/AU), William Brooks, Claire Shepherd (Sydney/AU), Justin Yerbury (Wollongong/AU), Glenda Halliday, Peter Schofield, John Kwok (Sydney/AU)

18:10 Global initiative to identify genetic modifiers of disease onset and presentation in patients with progranulin mutations O6 Cyril Pottier (Jacksonvile/US), Daniel J Serie (Jacksonville/US), Edward D Huey (New York/US), Manuela Neumann (Tuebingen/DE), Peter Johannsen (Copenhagen/DK), Jarosław Slawek (Gdańsk/PL), Elizabeth C Finger (London Ontario/CA), Carol F Lippa (Philadelphia/US), Charles L III White (Dallas/US), Thomas G Beach (Sun City/US), John B Kwok (Sydney/AU), Sandro Sorbi (Florence/IT), Bernardino Ghetti (Indianapolis/US), Marsel M Mesulam, Elieen H Bigio (Chicago/US), Raquel Sanchez-valle (Barcelona/ES), Stuart Pickering-Brown (Manchester/GB), Amalia Bruni (Lamezia terme/IT), Ekaterina Rogaeva (Toronto/CA), Jonathan D Rohrer (London/GB), Caroline Graff (Stockholm/SE), Ian R Mackenzie (Vancouver/CA), Thomas D Bird (Seattle/US), Carlos Cruchaga (Saint Louis/US), John C van Swieten (Rotterdam/NL), Bruce L Miller (San Francisco/US), Adolfo Lopez de Munain (San Sebastián/ES), Vivianna M Van Deerlin (Philadelphia/US), Giacomina Rossi (Milan/IT), Luisa Benussi, Barbara Borroni (Brescia/IT), Daniela Galimberti (Milan/IT), Roberta Ghidoni (Brescia/IT), Isabelle Le Ber (Paris/FR), Joanna Biernacka (Rochester/US), Dennis W Dickson (Jacksonvile/US), Neill R Graff-Radford (Jacksonville/US), Brad F Boeve (Rochester/US), Rosa Rademakers (Jacksonvile/US)

18:25 Loss of function mutations in dipeptidyl peptidase 6 in Alzheimer disease and Frontotemporal dementia: a novel pathway in neurodegeneration DB7 Rita Cacace (Antwerp/BE), Tobi Van den Bossche (Antwerp, Edegem/BE), Jonathan Lippiat (Leeds/GB), Jonathan Janssens (Antwerp/BE), Greet De Baets (Leuven/BE), Sebastiaan Engelborghs, Anne Sieben (Antwerp/BE), Mathieu Vandenbulcke (Leuven/BE), Peter de Rijk, Elise Cuyvers, Caroline Van Cauwenberghe, Caroline Robberecht, Lubina Dillen, Céline Merlin, Nathalie Geerts (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Jean-Jacques Martin, Peter P. De Deyn (Antwerp/BE), Joost Schymkowitz (Leuven/BE), Stuart Maudsley, Marc Cruts, Julie van der Zee, Kristel Sleegers, Christine Van Broeckhoven (Antwerp/BE)

18:27 Symptom Onset in Genetic Frontotemporal Dementia DB8 Katrina M Dick (London/GB), Bradley F Boeve (Minnesota, USA/US), Barbara Borroni (Brescia, Italy/IT), Adam Boxer (San Francisco, California/US), Alexis Brice (Paris, France/FR), Christopher R Butler (Oxford, UK/GB), Philippe Couratier (Limoges, France/FR), Bradford C Dickerson (Charlestown, MA, USA/US), Simon Ducharme (QC, Canada/CA), Elizabeth Finger (London, ON, Canada/CA), Daniela Galimberti (Milan, Italy/IT), Alexander Gerhard (Manchester, UK/GB), Nupur Ghoshal

ICFTD 2016 Program August 31, 2016

(MO, USA/US), Caroline Graff, (Stockholm, Sweden/SE), Murray Grossman, (Philadelphia, PA 19104, USA/US), John R Hodges, (Sydney, Australia/AU), Edward D Huey (New York, USA/US), Robert Laforce Jr (QC, Canada/CA), Isabelle Le Ber (Paris, France/FR), Johannes Levin (Munich, Germany/DE), Ian R Mackenzie (Canada/CA), Mario Masellis (Toronto Canada/CA), Olivier Martinaud (France/FR), Alexandre Mendonça, (Lisbon, Portugal/PT), Fermin Moreno (San Sebastián, Spain/ES), Jennifer M Nicholas, (London, London, UK/GB), Chiadi U Onyike (MD, USA/US), Markus Otto (Ulm, Germany/DE), Erik D Roberson (USA/US), Emily Rogalski (United States/US), Howard J Rosen (San Francisco, California/US), James B Rowe (Cambridge, UK/GB), Raquel Sanchez-Valle (Barcelona, Spain/ES), Isabelle Santana (Coimbra, Portugal/PT), Sandro Sorbi (Florence, Italy/IT), John van Swieten (Rotterdam, Netherlands/NL), Matthis Synofzik (Tuebingen, Germany/DE), Fabrizio Tagliavini (Milano, Italy/IT), Rik Vandenberghe (Leuven, Belgium/BE), Jonathan D Roher (London/GB)

18:29 ATXN2 polyQ intermediate repeats influence Frontotemporal Lobar Degeneration phenotype DB9 Elisa Rubino, Cecilia Mancini, Patrizia Ferrero, Marina Ferrone, Stefano Bianca, Silvia Boschi, Milena Zucca, Laura Orsi, Salvatore Gentile, Lorenzo Pinessi, Alfredo Brusco, Innocenzo Rainero (Turin/IT)

18:31 Gene-based analysis detects novel loci associated with frontotemporal dementia and its clinical subtypes DB10 Aniket Mishra (Amsterdam/NL), Raffaele Ferrari, FTD-GWAS Consortium (London, UK/GB), Peter Heutink (Tuebingen/DE), John Hardy (London, UK/GB), Yolande Pijnenburg, Danielle Posthuma (Amsterdam/NL)

18:35 Panel discussion: How do we move from large scale sequencing efforts in genetics to biology? Peter Heutink (Tuebingen/DE)

19:30–21:00 Welcome reception Room Foyer

ICFTD 2016 Program September 1, 2016

08:30–10:00 Session 4: Molecular neuropathology of FTLD Room Lecture Hall Chairs Manuela Neumann (Tuebingen/DE), Ian Mackenzie (Vancouver/CA)

08:30 Molecular neuropathology of FTLD with focus on C9orf72 mutations Ian Mackenzie (Vancouver/CA)

08:55 Evidence from human studies for spreading/staging of TDP-43 pathology in FTLD and ALS Glenda Halliday (Sydney/AU)

09:20 New Models For Alzheimer's And other Related Tauopathies By Transmission Of Neuronal And Glial Tau Pathology O7 John Trojanowski (Philadelphia/US)

09:35 Clinicopathological correlations in early vs. late age-of-onset frontotemporal dementia and frontotemporal lobar degeneration O8 Sang Won Seo, Marie-Pierre Thibodeau, David C. Perry, Alice Hua, Manu Sidhu, Stephanie E. Gaus, Gil Rabinovici, Katherine D. Rankin, Adam L. Boxer, Joel H. Kramer, Howard J. Rosen, Maria Luisa Gorno-Tempini, Lea T. Grinberg, Eric J. Huang, Stephen J. DeArmond, John Q. Trojanowski, Bruce L. Miller, William W. Seeley (San Francisco/US)

09:50 TTBK1/2 hyper-activation drives pTau and pTDP accumulation DB11 Laura Taylor, Pam McMillan, Nicole Liachko, Aleen Saxton, Tim Strovas, Brian Kraemer (Seattle/US)

09:52 Cerebrospinal fluid phosphorylated tau levels are associated with post-mortem tau inclusion burden in frontotemporal lobar degeneration DB12 David Irwin (Philadelphia/US), Alberto Lleo (Barcelona/ES), Corey McMillan, Felicia Cooper, David Wolk, Leslie Shaw, Edward Lee, John Trojanowski, Murray Grossman (Philadelphia/US)

09:54 Testing reversibility of pathology in a new in vitro model for C9orf72 ALS/FTD DB13 Frederike Riemslagh, Renate Hukema, Santoesha Nanhoe, Charlene den Hollander, Helen de Boer, John van Swieten, Rob Willemsen (Rotterdam/NL)

09:56 Abundant lower motor neuron RNA foci with perinucleolar studding in C9orf72 FTD- ALS DB14 Sarat Vatsavayai, Stephanie Gaus, Ji-Hye Hwang, Bruce Miller, William Seeley (San Francisco/US)

10:30–12:00 Session 5: Progressive aphasias Room Lecture Hall Chairs Marilu Gorno-Tempini (San Francisco, CA/US), Peter Nestor (Magdeburg/DE)

10:30 Apraxia of speech and its rehabilitation Maya Henry (Austin, TX/US)

10:55 The right hemisphere and its semantics Peter Garrard (London/GB)

ICFTD 2016 Program September 1, 2016

11:20 In vivo correlates of pathological diagnosis in clinical variants of primary progressive aphasia O9 Edoardo Gioele Spinelli (Milan, San Francisco/IT), Maria Luisa Mandelli, Miguel Santos (San Francisco/US), Stephen M Wilson (Tucson/US), Federica Agosta (Milan/IT), John Q Trojanowski (Philadelphia/US), Eric J Huang, Lea T Grinberg (San Francisco/US), Massimo Filippi (Milan/IT), Bruce L Miller, William W Seeley, Maria Luisa Gorno-Tempini (San Francisco/US)

11:35 Imaging tDCS effects in primary progressive aphasia O10 Kyrana Tsapkini, Yenny Webb-Vargas, Andreia Faria, Bronte Ficek, Tushar Chakravarty, Constantine Frangakis, John Desmond, Martin Lindquist, Argye Hillis (Baltimore/US)

11:50 Bilingualism in primary progressive aphasia: systematic review and case reports from two European centers DB15 Ana Sofia Costa (Braga/PT), Jennifer Wojtala (Aachen/DE), Sofia Rocha (Braga/PT), Kathrin Reetz (Aachen/DE), Alvaro Machado (Braga/PT)

11:52 Differential binding of AV-1451 tau-PET across variants of primary progressive aphasia DB16 Jennifer Whitwell, Nirubol Tosakulwong, Joseph Duffy, Heather Clark, Mary Machulda, Edythe Strand, Matthew Senjem, Ronald Petersen, Clifford Jack, Val Lowe, Keith Josephs (Rochester/US)

11:54 Deficits in Rhythm Processing in PPA are linked to SMA atrophy DB17 Jolien Schaeverbeke, Rose Bruffaerts (Leuven/BE), Manon Grube (Berlin, Newcastle-upon-Tyne/GB), Veerle Neyens (Leuven/BE), Bruno Bergmans (Brugge/BE), Eva Dries (Leuven/BE), Tim Griffiths (Newcastle-upon-Tyne/GB), Rik Vandenberghe (Leuven/BE)

11:56 Anatomo-functional segregation of the mental lexicon: the model of Primary Progressive Aphasia DB18 Clara Sanches, Marc Teichmann, Olivier Colliot (Paris/FR), Alexandre Routier (Paris/FI), Rafaella Miggliaccio (Paris/FR)

12:00–14:00 Postersession II - Genetics Room Ballroom

P157 C9orf72, does the size matter? Clemence Fournier, Vincent Anquetil, Agnès Camuzat, Mathieu Barbier (PARIS/FR), Valérie Buée-Scherrer, Vincent Deramecourt, Nicolas Sergeant, Florence Pasquier (Lille/FR), GIE NeuroCEB Network (Paris/FR), Bruno Dubois, Charles Duyckaerts (PARIS, Paris/FR), Alexis Brice (PARIS/FR), Isabelle Le Ber (PARIS, Paris/FR)

P158 RNA metabolism in Frontotemporal dementia. Vincent Anquetil, Agnès Camuzat, Clemence Fournier, Pierre de la Grange, Mathieu Barbier (Paris/FR), Valérie Buée-Scherrer, Vincent Deramecourt, Nicolas Sergeant, Florence Pasquier (Lille/FR), Bruno Dubois, Véronique Sazdovitch, Danielle Seilhean (Paris/FR), Luc Buée (Lille/FR), Alexis Brice, Charles Duyckaerts, Isabelle Le Ber (Paris/FR)

ICFTD 2016 Program September 1, 2016

P159 A cluster of progranulin C157KfsX97 mutations in Southern Italy: clinical characterisation and genetic correlations Dario Saracino, Cinzia Coppola, Gianfranco Puoti, Giacomo Lus, Clemente Dato (Naples/IT), Isabelle Le Ber (Paris/FR), Paola Caroppo, Elena Piccoli, Fabrizio Tagliavini (Milan/IT), Giuseppe Di Iorio (Naples/IT), Giacomina Rossi (Milan/IT)

P160 Genetic screening of C9orf72 and TBK1 mutations and clinical correlations in combined FTLD/ ALS phenotypes Estrella Gómez-Tortosa, María Ruggiero (Madrid/ES), Emilio Franco-Macías (Seville/ES), Cristina Prieto-Jurczynska, Begoña Venegas, Carlos Ordás, Silvia Gil Navarro, Rosa Guerrero, Julián Pérez-Pérez, Mª José Sainz (Madrid/ES)

P161 TBK1 mutation frequencies and associated phenotypes in French frontotemporal dementia and amyotrophic lateral sclerosis cohorts Agnes Camuzat, Paola Caroppo, Anne De Septenville, Stephanie Millecamps (PARIS/FR), Philippe Couratier (LIMOGES/FR), Mathieu Barbier (PARIS/FR), Frederic Blanc (STRASBOURG/FR), Lucette Lacomblez (PARIS/FR), François Sellal, Marie-Celine Fleury (STRASBOURG/FR), Alexis Brice, Isabelle Le Ber (PARIS/FR), French Clinical and Genetic Research Network on FT French Clinical and Genetic Research Network on FT (France/FR)

P162 Clinical features of TBK1 carriers and comparison with Belgian FTD patients carrying another FTD-TDP causing mutation. Sara Van Mossevelde (Antwerp, Wilrijk, Edegem/BE), Julie van der Zee, Ilse Gijselinck (Antwerp, Wilrijk/BE), Sebastiaan Engelborghs (Wilrijk, Antwerp/BE), Anne Sieben (Antwerp, Wilrijk, Ghent/BE), Tim Van Langenhove (Antwerp, Wilrijk, Edegem/BE), Jan De Bleecker (Ghent/BE), Jonathan Baets (Antwerp, Wilrijk, Edegem/BE), Mathieu Vandenbulcke, Koen Van Laere (Leuven/BE), Sarah Ceyssens (Antwerp, Edegem/BE), Marleen Van den Broeck, Karin Peeters, Maria Mattheijssens (Antwerp, Wilrijk/BE), Patrick Cras (Wilrijk, Edegem/BE), Rik Vandenberghe (Leuven/BE), Peter De Jonghe (Antwerp, Wilrijk, Edegem/BE), Jean- Jacques Martin (Wilrijk/BE), Peter P. De Deyn (Wilrijk, Antwerp/BE), Marc Cruts, Christine Van Broeckhoven (Antwerp, Wilrijk/BE)

P163 TBK1 loss-of function and dominant-negative mutations in an extended European cohort of FTD and ALS patients. Julie van der Zee, Ilse Gijselinck, Sara Van Mossevelde, Federica Perrone, Sebastiaan Engelborghs (Antwerp/BE), Jan De Bleecker (Ghent/BE), Jonathan Baets (Antwerp/BE), Ellen Gelpi (Barcelona/BE), Ricardo Rojas-García (Barcelona/ES), Jordi Clarimón, Alberto Lleó (Barcelona, Madrid/ES), Janine Diehl-Schmid, Panagiotis Alexopoulos (Munchen/DE), Robert Perneczky (Munchen, London/DE), Matthis Synofzik, Jennifer Just, Ludger Schöls (Tuebingen/DE), Caroline Graff, Håkan Thonberg (Stockholm/SE), Barbara Borroni, Alessandro Padovani (Brescia/IT), Albena Jordanova (Antwerp, Sofia/BE), Stayko Sarafov, Ivailo Tournev (Sofia/BG), Alexandre de Mendonça, Gabriel Miltenberger-Miltényi, Frederico Simões do Couto (Lisbon/PT), Alfredo Ramirez (Bonn/DE), Frank Jessen (Bonn, Cologne/DE), Michael T. Heneka (Bonn/DE), Estrella Gómez-Tortosa (Madrid/ES), Adrian Danek (Munich/DE), Patrick Cras (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Peter De Jonghe, Peter P. De Deyn, Kristel Sleegers, Marc Cruts, Christine Van Broeckhoven, BELNEU consortium, EUEOD consortium (Antwerp/BE)

P164 Large-scale Whole Genome Sequencing in ALS: Project MinE Michael van Es (Utrecht/NL)

ICFTD 2016 Program September 1, 2016

P165 Investigating the genetic impact of TUBA4A in a Belgian cohort of FTD and ALS patients Federica Perrone, Hung Nguyen Phuoc, Sara Van Mossevelde (Antwerp/BE), Anne Sieben (Antwerp, Ghent/BE), Jan De Bleecker (Ghent/BE), Mathieu Vandenbulcke, Rik Vandenberghe (Leuven/BE), Sebastiaan Engelborghs, Jonathan Baets, Peter De Jonghe, Patrick Cras, Peter De Deyn, Jean-Jacques Martin, Julie van der Zee, Christine Van Broeckhoven (Antwerp/BE)

P166 Investigating the role of rare heterozygous CHCHD10 variants in a Belgian cohort of FTD and ALS patients Hung Nguyen Phuoc, Federica Perrone, Sara Van Mossevelde (Antwerp/BE), Anne Sieben (Antwerp, Ghent/BE), Patrick Santens, Jan De Bleecker (Ghent/BE), Rik Vandenberghe, Mathieu Vandenbulcke (Leuven/BE), Sebastiaan Engelborghs, Jonathan Baets, Peter De Jonghe, Patrick Cras, Peter De Deyn, Jean Jacques Martin, Julie Van Der Zee, Christine Van Broeckhoven (Antwerp/BE)

P167 Founder effect of P301L MAPT mutation in families with FTD in Baix Llobregat County (Barcelona, Spain) Leire Palencia-Madrid (Vitoria/ES), Sergi Borrego, Oriol Grau-Rivera, Ramon Reñe, Isabel Hernandez (Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat, Barcelona/ES), Anna Antonell, Mircea Balasa, Albert Llado (Barcelona/ES), Ellen Gelpi (Barcelona/BE), Marian M. de Pancorbo (Vitoria/ES), Raquel Sanchez-Valle (Barcelona/ES)

P168 ANALYSIS OF GENETIC POLIMORPHISMS AND GENETIC MUTATIONS IN FRONTOTEMPORAL LOBAR DEGENERATION María José Gil Moreno (Torrejón de Ardoz, Madrid/ES), María Sagrario Manzano Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Miguel Calero Lara, Alberto Rábano Gutiérrez (Madrid/ES)

P169 Impaired LTP-like cortical plasticity and intra-cortical facilitation in presymptomatic FTLD mutation carriers. Alberto Benussi, Maura Cosseddu, Ilaria Filareto, Valentina Dell'Era, Silvana Archetti, Maria Sofia Cotelli (Brescia/IT), Anna Micheli (Bergamo/IT), Alessandro Padovani, Barbara Borroni (Brescia/IT)

P170 Frontotemporal lobar degeneration spectrum: the first genetic screen in a Greek cohort Suzee Lee (San Francisco/US), Eliana Marisa Ramos (Los Angeles/US), Christos Kroupis, Christos Koros (Athens/GR), Victoria Van Berlo, Kevin Wojta, Qing Wang, Deepika Dokuru, Mochtar Pribadi (Los Angeles/US), Anastasios Bonakis, Vasiliki Papastefanopoulou, John Papatriantafyllou (Athens/GR), Bruce Miller (San Francisco/US), Leonidas Stefanis (Athens/GR), Giovanni Coppola (Los Angeles/US), Sokratis G. Papageorgiou (Athens/US)

P171 More than two-hundred and fifty FTD patients looking for genes: results from Italian FTD Network Antonella Alberici (Brescia/IT), Benedetta Nacmias (Florence/IT), Giancarlo Logroscino (Lecce/IT), Amalia Bruni (Lamezia Terme, Catanzaro/IT), Fabrizio Tagliavini (Milan/IT), Roberta Ghidoni (Brescia/IT), Daniela Galimberti (Milan/IT), Laura Bonanni (Chieti/IT), Annachiara Cagnin (Padua/IT), Marco Bozzali (Rome/IT), Vincenzo Silani (Milan/IT), Rosanna Turrone (Brescia/IT), Camilla Ferrari, Gemma Lombardi, Valentina Bessi (Florence/IT), Rosa Capozzo, Chiara Zecca, Simone Arcuti (Lecce/IT), Chiara Cupidi, Livia Bernardi, Nicoletta Smirne, Francesca Frangipane (Lamezia Terme, Catanzaro/IT), Giacomina Rossi, Paola Caroppo, Pietro Tiraboschi (Milan/IT), Luisa Benussi, Giuliano Binetti, Miriam Ciani, Silvia Fostinelli

ICFTD 2016 Program September 1, 2016

(Brescia/IT), Andrea Arighi, Chiara Fenoglio, Giorgio Fumagalli (Milan/IT), Marco Onofrj (Chieti/IT), Elio Scarpini (Milan/IT), Sandro Sorbi (Florence/IT), Alessandro Padovani, Barbara Borroni (Brescia/IT)

P173 TREM2 variant p.His157Tyr in Colombian patients with frontotemporal dementia. Andrea Lopez-Caceres, Andres Laserna (Bogotá/CO), Cristian Triviño-Martínez, Elkin Garcia-Cifuentes (Bogota/CO), Juan Carlos Gómez-Vega, Paola Ayala- Ramírez (Bogotá/CO), Pablo Reyes, Hernando Santamaría-García, Jose Manuel Santacruz (Bogota/CO), Ignacio Zarante (Bogotá/CO), Diana Matallana (Bogota/CO)

P174 Utilizing FTD-associated MAPT-S305 mutations to develop cell models that express 4R Tau Kathryn Bowles, Alison Goate (New York/US)

P175 Unraveling the genetic role of SORT1 in the Belgian frontotemporal dementia population Stephanie Philtjens, Eline Wauters, Sara Van Mossevelde, Julie van der Zee, Tim Van Langenhove, Sebastiaan Engelborghs (Antwerp/BE), Mathieu Vandenbulcke (Leuven/BE), Maarten Versteven, Karin Peeters, Maria Mattheijssens, Marleen Van den Broeck, Patrick Cras (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Peter P. De Deyn, Marc Cruts, Christine Van Broeckhoven (Antwerp/BE)

P176 Differences in rate of participation in clinical research studies in asymptomatic members of families with frontotemporal dementia (FTD) Ging-Yuek R. Hsiung, Pheth Sengdy, Emily Dwosh (Vancouver/CA), Matt Baker, Rosa Rademakers (Jacksonville/US), Howard Feldman, Ian R. Mackenzie (Vancouver/CA)

P177 Right temporal variant frontotemporal dementia with motor neuron disease: a novel association with the C9orf72 expansion Ione Woollacott, Katrina Dick, Elizabeth Gordon, Martina Bocchetta, Sophie Harding, Katie Sidle, Jason Warren, Jonathan Rohrer (London/GB)

P178 VALIDATION OF FRONTOTEMPORAL LOBAR DEGENERATION PEDIGREE CLASSIFICATION CRITERIA IN A NORTHERN ITALY COHORT: IMPLICATIONS FOR GENETIC TESTING AND COUNSELING LUISA BENUSSI, SILVIA FOSTINELLI, MIRIAM CIANI, ROBERTA ZANARDINI, GIULIANO BINETTI, ROBERTA GHIDONI (BRESCIA/IT)

P179 Molecular mechanism of genetic anticipation in C9orf72 repeat expansion families Marc Cruts, Ilse Gijselinck, Sara Van Mossevelde, Julie van der Zee, Anne Sieben, Sebastiaan Engelborghs (Antwerp/BE), Jan De Bleecker (Ghent/BE), Adrian Ivanoiu (Brussels/BE), Olivier Deryck (Bruges/BE), Bavo Heeman, Veerle Bäumer, Marleen Van den Broeck, Maria Mattheijssens, Karin Peeters (Antwerp/BE), Peter De Jonghe, Patrick Cras (Antwerp, Edegem/BE), Jean-Jaques Martin, Peter Paul De Deyn, Christine Van Broeckhoven (Antwerp/BE)

P180 The genetic landscape of clinical FTD: a systematic whole-exome sequencing study of 125 consecutive cases Cornelis Blauwendraat, Carlo Wilke, Iris Jansen, Patrizia Rizzu, Javier Simón- Sánchez, Peter Heutink, Matthis Synofzik (Tuebingen/DE)

P181 Myelin Oligodendrocyte Basic Protein and Longitudinal Decline in Behavioral-Variant Frontotemporal Degeneration Lauren Massimo, Lior Rennert, Sharon Xie, Vivianna Van Deerlin, David Irwin, Corey McMillan, Murray Grossman (Philadelphia/US)

ICFTD 2016 Program September 1, 2016

P182 Genetic overlap between 4-repeat tauopathies suggests a role for development in the pathobiology of corticobasal degeneration Jennifer Yokoyama (San Francisco/US), Chun Fan (San Diego/US), Yunpeng Wang (Oslo/NO), Naomi Kouri (Jacksonville/US), Raffaele Ferrari (London/GB), Ole Andreassen (Oslo/NO), John Hardy (London/GB), Adam Boxer, Bruce Miller (San Francisco/US), Gerard Schellenberg (Philadelphia/US), Dennis Dickson (Jacksonville/US), Anders Dale (San Diego/US), Rahul Desikan (San Francisco/US)

P183 Effects of multiple genetic loci on age at onset in frontotemporal dementia Raffaele Ferrari (London/GB), M Grassi, F Graziano, F Palluzzi (Pavia/IT), S Archetti, E Bonomi (Brescia/IT), AC Bruni, RG Maletta, L Bernardi, C Cupidi, R Colao (Lamezia Terme/IT), I Rainero, E Rubino, L Pinessi (Torino/IT), D Galimberti, E Scarpini, M Serpente (Milan/IT), B Nacmias, I Piaceri, S Bagnoli (Florence/IT), G Rossi (Florence, Milan/IT), G Giaccone, F Tagliavini (Milan/IT), L Benussi, G Binetti, R Ghidoni (Brescia/IT), A Singleton (Bethesda/US), J Hardy, P Momeni (London/GB), A Padovani, B Borroni (Brescia/IT)

P184 Epigenetic modification in Italian FTLD patients carrying the C9orf72 repeat expansion Irene Piaceri, Andrea Tedde, Gemma Lombardi, Camilla Ferrari, Valentina Bessi, Sandro Sorbi, Benedetta Nacmias, Silvia Bagnoli (Florence/IT)

P185 NIH EXAMINER as tool for tracking executive dysfunction in carriers of FTLD- causing mutations within the LEFFTDS Consortium Howard Rosen, Peter Ljubenkov (San Francisco/US), Brad Boeve (Rochester/US), Joel Kramer, Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel, Julie Fields, Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman (Philadelphia/US), Hilary Heuer (San Francisco/US), John Hsiao (Bethesda/US), Ging-Yuek R. Hsiung (Vancouver/CA), Edward D. Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas (San Francisco/US), David Knopman (Rochester/US), John Kornak (San Francisco/US), Walter Kukull (Seattle/US), Ian Mackensie (Vancouver/US), Bruce Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US), Tatiana Faroud, Kelly Faber, Ashley Vetor (Indianapolis/US), John Trojanowski (Philadelphia/US), Katherine Rankin (San Francisco/US)

P186 TMEM106B polymorphism is associated with lower cortical volumes in a clinically diagnosed FTD cohort Sophie R. Harding, Martina Bocchetta, Elizabeth Gordon, Dave M. Cash, M. Jorge Cardoso, Gary Adamson, Sebastien Ourselin, Jason D. Warren, Simon Mead, Jonathan D. Rohrer (London/GB)

P187 The genetic correlation between Frontotemporal Dementia (FTD), and neurodevelopmental diseases, and the convergence in functional pathways. Erdogan Taskesen, Aniket Mishra, Danielle Posthuma (Amsterdam/NL), Yolande Pijnenburg (Amsterdam, Londen/NL)

P188 Familial frontotemporal dementia - ALS syndrome by TARDBP gene mutation Mikel Olabarrieta, Francesc Pujadas, Antonio Palasi (Barcelona/ES), Antoni Turon (Salt (Girona)/ES), Anna Antonell (Barcelona/ES), Ellen Gelpi (Barcelona/BE), Raquel Sánchez-Valle (Barcelona/ES)

ICFTD 2016 Program September 1, 2016

P189 Absence of Differences on Key Measures in Mildly (CDR=0.5) Versus Overtly (CDR≥1) Symptomatic Mutation Carriers: Preliminary Data From LEFFTDS David Knopman, Bradley Boeve (Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US), Bradley Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields (Rochester/US), Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman (Philadelphia/US), Hillary Heuer (San Francisco/US), John Hsiao (Bethesda/US), Edward Huey (New York/US), Robin Hsiung (Vancouver/CA), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas, John Kornak, Joel Kramer (San Francisco/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine Rankin (San Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US), Ashley Vetor (Indianapolis/US)

P190 The genetic and epidemiology of frontotemporal dementia in Sardinia Francesca Di Stefano, Giuseppe Borghero, Antonino Cannas, Angela Sanna (Monserrato/IT), Maria Rita Murru, Daniela Corongiu, Stefania Cuccu, Stefania Tranquilli, Maria Giovanna Marrosu (Cagliari/IT), Adriano Chiò (Turin/IT), Francesco Marrosu, Gianluca Floris (Monserrato/IT)

P191 Differences on Clinical Measures in Asymptomatic (CDR=0) Versus Mildly Symptomatic (CDR=0.5) Mutation Carriers: Preliminary Data From LEFFTDS David Knopman, Bradley Boeve (Rochester/US), Howard Rosen, Adam Boxer (San Francisco/US), Giovanni Coppola (Los Angeles/US), Christina Dheel (Rochester/US), Bradley Dickerson (Boston/US), Kelly Faber (Indianapolis/US), Julie Fields (Rochester/US), Tatiana Foroud (Indianapolis/US), Ralitza Gavrilova (Rochester/US), Nupur Ghoshal (St. Louis/US), Jill Goldman (New York/US), Neill Graff-Radford (Jacksonville/US), Murray Grossman (Philadelphia/US), Hillary Heuer (San Francisco/US), John Hsiao (Bethesda/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Anna Karydas, Joel Kramer (San Francisco/US), Walter Kukull (Seattle/US), Ian Mackenzie (Vancouver/CA), Bruce Miller (San Francisco/US), Creighton Phelps (Bethesda/US), Rosa Rademakers (Jacksonville/US), Katherine Rankin (San Francisco/US), Les Shaw (Philadelphia/US), Margaret Sutherland (Bethesda/US), Arthur Toga (Los Angeles/US), John Trojanowski (Philadelphia/US), Ashley Vetor (Indianapolis/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville/US)

P192 Estimation of Age of Onset in Presymptomatic Frontotemporal Degeneration Prerana Vaddi, Elisabeth Mccarty Wood, Vivianna Van Deerlin, David Irwin, Murray Grossman, Corey McMillan (Philadelphia/US)

P193 Targeted Multi-Gene Panel Sequencing in Korean Patients with Frontotemporal Dementia: A preliminary result Eun-Joo Kim (Busan/KR), Young-Eun Kim, Ja-Hyun Jang, Eun-Hae Cho (Yongin/KR), Jay C. Kwon (Changwon/KR), Ki-Hyeong Park (Incheon/KR), Kyung Won Park (Busan/KR), Jae-Hong Lee (Seoul/KR), Seong Hye Choi (Incheon/KR), Soo Jin Yoon (Daejeon/KR), Jee H. Jeong, Byung-Ok Choi, Duk L. Na, Chang-Seok Ki, Seung Hyun Kim (Seoul/KR)

ICFTD 2016 Program September 1, 2016

P194 Effect of predictive testing in adult onset neurodegenerative diseases on social and personal life – a pilot study Petra Cohn-Hokke (Amsterdam/NL), John van Swieten (Amsterdam, Rotterdam/NL), Aad Tibben (Leiden/NL), Hanne Meijers-Heijboer (Amsterdam/NL), Anneke Kievit (Rotterdam/NL)

P195 Gene-group based genetic burden tests reveals additional candidate genes for FTD. Jeroen van Rooij, Tsz-Hang Wong (Rotterdam/NL), Javier Simón-Sánchez, Cornelis Blauwendraat, Patrizia Rizzu (Tuebingen/DE), Peter Heutink (Tuebingen, Amsterdam/DE), Matthis Synofzik (Tuebingen/DE), André Uitterlinden, Joyce van Meurs, John van Swieten (Rotterdam/NL)

P196 The phenotypic variability of c9orf72 mutations: at the interface between neurology and psychiatry Carola Rossmeier, Dieter Edbauer, Janine Diehl-Schmid (Munich/DE)

P197 Anthropometric measures of asymptomatic individuals at-risk for familial frontotemporal dementia Ging-Yuek Hsiung, Pheth Sengdy (Vancouver/CA), Matt Baker, Rosa Rademakers (Jacksonville/US), Howard Feldman, Ian Mackenzie (Vancouver/CA)

P198 TMEM106B and APOE as genetic modifiers of FTD-3 in the Danish CHMP2B family Peter Roos, Nina Rostgaard, Peter Johannsen (DK-2100 København Ø/DK), Jeremy M. Brown (Cambridge, UK/GB), Adrian M. Isaacs (London, UK/GB), Gunhild Waldemar, Troels T. Nielsen (DK-2100 København Ø/DK), Jørgen E. Nielsen (DK- 2100 København Ø, Copenhagen, DK/DK)

P199 Probing FTD genetics with a next-generation sequencing gene panel Carolin Koriath, Gary Adamson, Ron Druyeh, Janna Kenny, Martin Rossor, Jon Schott, Catherine Mummery, Nick Fox, Jason Warren, John Collinge, Jon Rohrer, Simon Mead (London/GB)

P200 Reduced disease penetrance of progranulin mutation p.tyr294* - a case report Linn Öijerstedt (Stockholm, Huddinge, Stockholm/SE), Christin Andersson (Huddinge, Stockholm/SE), Vesna Jelic, Caroline Graff (Stockholm, Huddinge, Stockholm/SE)

P201 Prevalence, phenotypic variability and neuropsychological findings of C9orf72 mutations in a Bulgarian dementia cohort Shima Mehrabian (Sofia/BG), Hakan Thonberg, Bengt Winblad (Stockholm/SE), Margarita Raycheva (Sofia/SE), Lena Lilius (Stockholm/SE), Katya Stoyanova (Sofia/BG), Charlotte Forsell (Stockholm/SE), Draga Toncheva (Sofia/BG), Lena Cavallin, Eric Westman (Stockholm/SE), Latchezar Traykov (Sofia/BG), Caroline Graff (Stockholm/SE)

P202 Frequency and contribution of variants in 17 dementia related genes in a Bulgarian dementia cohort Hakan Thonberg (Stockholm/SE), Shima Mehrabian (Sofia/BG), Bengt Winblad (Stockholm/SE), Katya Stoyanova (Sofia/BG), Charlotte Forsell (Stockholm/SE), Margarita Raycheva (Sofia/SE), Lena Lilius (Stockholm/SE), Draga Toncheva, Latchezar Traykov (Sofia/BG), Caroline Graff (Stockholm/SE)

P203 Double mutations in TREM2 and C9orf72 genes in a Bulgarian individual with atypical FTD phenotype and rapid progression Latchezar Traykov, Shima Mehrabian (Sofia/BG), Hakan Thonberg (Stockholm/SE), Margarita Raycheva (Sofia/SE), Charlotte Forsell (Stockholm/SE), Katya Stoyanova

ICFTD 2016 Program September 1, 2016

(Sofia/BG), Lena Lilius (Stockholm/SE), Draga Toncheva (Sofia/BG), Mariann Harangi (Debrecen/HU), Gabor G. Kovacs (Vienna/AT), Bengt Winblad, Caroline Graff (Stockholm/SE)

P204 Colombian Familial Dementia with Frontotemporal Features Associated with a Presenilin-1 Mutation Diana Matallana (Bogotá/CO), Katya Rascovsky (Philadelphia, PA/US), Paola Ayala, Andrea Lopez, Ignacio Zarante (Bogotá/CO), Corey McMillan, David Irwin, Beth McCarty-Wood, Viviana Van Deerlin, EunRan Suh, Murray Grossman (Philadelphia, PA/US)

P205 Sporadic frontotemporal dementia: polygenicity and pleiotropy Raffaele Ferrari (London/GB), Yunpeng Wang (Oslo/NO), Jana Vandrovcova (London/GB), Anders M Dale (St. Louis/US), Ole A Andreassen (Oslo/NO), Bruce Miller, Rahul S Desikan (San Francisco/US)

P206 NeuroX to screen neuro-genes in large FTLD cohort Raffaele Ferrari, John Hardy (London/GB)

P207 GRN c.708+1_+4delTGAG DELETION IN A LARGE FAMILY DIAGNOSED WITH FRONTO-TEMPORAL DEMENTIA Gulsen BABACAN-YILDIZ (Istanbul/TR), Gamze GUVEN, Hasmet HANAGASI, Basar BILGIC, Hakan GURVIT, Nihan ERGINEL-UNALTUNA (ISTANBUL/TR), Rita GUEIRREIRO (ISTANBUL/GB), Ebba LOHMANN (ISTANBUL, Tuebingen/DE)

P208 Evaluation of a Novel PCR Technology for the Quantification of C9orf72 Hexanucleotide Repeat Expansions Eran Bram, Kristen Culp, Nathan Nevitt, Jon Kemppainen, Gary Latham (Austin/US), EunRan Suh, Kaitlyn Grando, Vivianna Van Deerlin (Philadelphia/US)

P209 CLINICAL AND GENETIC ANALYSES OF FAMILIAL AND SPORADIC FRONTOTEMPORAL DEMENTIA PATIENTS IN SOUTHERN ITALY ( The Apulia_FTD_Registry) Rosa Capozzo (Tricase, Lecce/IT), Celeste Sassi (Bethesda, MD, USA, London, UK/US), Monia Benahmed-Hammer (Bethesda, MD, USA/US), Simona Arcuti, Chiara Zecca, Maria Rosaria Barulli, Rosanna Tortelli (Tricase, Lecce/IT), Francesco Carnicella, Claudia Dell'Aquila (Andria, Italy/IT), Francesco Valluzzi (Monopoli, Italy, /IT), Francescop Panza (Tricase, Lecce, Bari, Italy/IT), Andrew Singleton (Bethesda, MD, USA/US), Giancarlo Logroscino (Tricase, Lecce, Bari/IT)

P210 Frontotemporal lobar degeneration spectrum: first genetic screen in a Greek cohort Eliana Marisa Ramos (Los Angeles, CA, USA/US), Suzee Lee (San Francisco/US), Christos Kroupis, Christos Koros (Athens/GR), Victoria Van Berlo, Kevin Wojta, Qing Wang, Deepika Dokuru, Mochtar Pribadi (Los Angeles, CA, USA/US), Anastasios Bonakis, Vasiliki Papastefanopoulou, John Papatriantafyllou (Athens/GR), Bruce Miller (San Francisco/US), Leonidas Stefanis (Athens/GR), Giovanni Coppola (Los Angeles, CA, USA/US), Sokratis G. Papageorgiou (Athens/US)

P211 Psychiatric symptoms in CDR=0 MAPT mutation carriers Edward Huey, Gayathri Cheran, Jill Goldman, Masood Manoochehri, Sarah Cines (New York, NY/US), Tim Lynch, Brendan Kelly (Dublin/IE), Sarah Shair, Judith Heidebrink, Henry Paulson (Ann Arbor/US), Stephanie Cosentino (New York, NY/US)

P212 Investigation of Mutation Related Covariance Pattern in Asymptomatic Carriers of GRN and C9ORF72 mutations using [F18]-FDG PET

ICFTD 2016 Program September 1, 2016

Elham Shahinfard, Jessie Fu (Vancouver, B.C./CA), Claudia Jacova (Oregon/US), Dinelle Katie, Pheth Sengdy, Siobhan McCormick (Vancouver, B.C./CA), Vesna Sossi (Vancouver, Vancouver, B.C./CA), A. Jonathan Stoessl, Howard Feldman, Ian Mackenzie, Ging-Yuek Robin Hsiung (Vancouver, B.C./CA)

P213 Results of a diagnostic NGS gene panel for patients with dementia. Resie Vervenne - van Spaendonk, Fred van Ruissen, Margriet Smit, Daphne van Beek, Petra Cohn-Hokke, Erik Sistermans, Janneke Weiss (Amsterdam/NL)

P214 Genetic mutations in Frontemporal dementia - report from the memory clinic from Serbia Elka Stefanova, Gorana Mandic, Valerija Dobricic, Tanja Stojkovic, Milena Jankovic, Ivana Novakovic, Vladimir Kostic

P215 Closing the tau loop: the missing tau mutation Allan McCarthy (Dublin/IE), Roisin Lonergan (Dublin/US), Diana Olszewska, Sean O'Dowd (Dublin/IE), Gemma Cummins (Cambridge/GB), Brian Magennis, Emer Fallon, Niall Pender (Dublin/IE), Edward Huey, Stephanie Cosentino (New York, NY/US), Killian O'Rourke, Brendan Kelly, Martin O'Connell (Dublin/IE), Isabelle Delon (Cambridge/GB), Michael Farrell (Dublin/IE), Maria Grazia Spillantini (Cambridge/GB), Lewis Roland, Stanley Fahn (New York, NY/US), Peter Craig, Michael Hutton (Surrey/GB), Tim Lynch (Dublin/IE)

P216 Bioinformatics and FTD: using genes to untangle molecular underpinnings of disease Raffaele Ferrari (London/GB)

P217 C9orf72 repeat expansions and TARDBP mutations in two Brazilian Dementia Research Centers Leonel Takada, Valeria Bahia (Sao Paulo/BR), Henrique Guimarães, Leonardo Souza (Belo Horizonte/BR), Thais Costa (Sao Paulo/BR), Thiago Vale (Belo Horizonte/BR), Roberta Rodriguez, Fabio Porto (Sao Paulo/BR), João Machado, Rogério Beato (Belo Horizonte/BR), Karolina Cesar, Jerusa Smid, Sonia Brucki, Jessica Maximino (Sao Paulo/BR), Sarah Camargos (Belo Horizonte/BR), Gerson Chadi (Sao Paulo/BR), Paulo Caramelli (Belo Horizonte/BR), Ricardo Nitrini (Sao Paulo/BR)

12:00–14:00 Postersession II - Neuropathology Room Ballroom

P218 Multiple accumulation of neurodegenerative disease-related proteins in familial granulin mutation brains Masato Hosokawa (Tokyo/JP), Tetsuaki Arai (Tokyo, Tsukuba/JP), Hiromi Kondo (Tokyo/JP), Geidy Serrano, Thomas Beach (Sun City/US), Masato Hasegawa, Haruhiko Akiyama (Tokyo/JP)

P219 P301L MAPT mutation with globular glial inclusions Sergi Borrego (Barcelona/ES), Joana Morgado (Lisboa/PT), Oriol Grau (Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat/ES), Mircea Balasa, Albert Lladó, Raquel Sánchez-Valle (Barcelona/ES), Ellen Gelpi (Barcelona/BE)

ICFTD 2016 Program September 1, 2016

P220 Clinical and neuropathological features of Frontotemporal dementia caused by the P301L MAPT mutation in Baix Llobregat County (Barcelona, Spain) Sergi Borrego (Barcelona/ES), Joana Morgado (Lisboa/PT), Oriol Grau (Barcelona/ES), Ramón Reñé (Hospitalet del Llobregat/ES), Isabel Hernández (Barcelona/ES), Consuelo Almenar (Sant Boi de Llobregat/ES), Mircea Balasa, Anna Antonell, Albert Lladó (Barcelona/ES), Ellen Gelpi (Barcelona/BE), Raquel Sánchez- Valle (Barcelona/ES)

P221 Generation of specific and sensitive antibodies against C9orf72 Petra Frick (Tuebingen/DE), Dieter Edbauer, Elisabeth Kremmer, Regina Feederle (Munich/DE), Ian Mackenzie (Vancouver/CA), Jeroen Pasterkamp (Utrecht/NL), Manuela Neumann (Tuebingen/DE)

P222 CLINICAL AND NEUROPATHOLOGICAL CLASSIFICATION OF FRONTOTEMPORAL DEMENTIA: ANALYSYS OF COMMON AND SPECIFIC CHARACTERISTICS María José Gil Moreno (Madrid/ES), María Sagrario Manzano Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Gutiérrez (Madrid/ES)

P223 CEREBROVASCULAR PATHOLOGY IN FRONTOTEMPORAL LOBAR DEGENERATION: A NEUROPATHOLOGICAL STUDY María José Gil Moreno (Torrejón de Ardoz, Madrid/ES), María Sagrario Manzano Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Guitérrez (Madrid/ES)

P224 ARGYROPHILIC GRAINS PATHOLOGY IN FRONTOTEMPORAL LOBAR DEGENERATION María José Gil Moreno (Torrejón de Ardoz, Madrid/ES), María Sagrario Manzano Palomo (Parla, Madrid/ES), María Luz Cuadrado Pérez, Alberto Rábano Gutiérrez (Madrid/ES)

P225 Neuropathology of ALS with Dementia Eileen Bigio, Yasushi Nishihira, Qinwen Mao, Sandra Weintraub, Nailah Siddique, Teepu Siddique, M-Marsel Mesulam (Chicago/US)

P226 106 FTD cases with refined neuropathological confirmation. Anne Sieben (Wilrijk, Gent, Antwerp/BE), Sara Van Mossevelde, Julie van der Zee (Wilrijk, Antwerp/BE), Joery Goossens (Wilrijk/BE), Peter Paul De Deyn (Wilrijk, Groningen, Antwerp/BE), Patrick Cras (Wilrijk, Edegem/BE), Sebastiaan Engelborghs, Christine Van Broeckhoven (Wilrijk, Antwerp/BE), Jean-Jacques Martin (Wilrijk/BE)

P228 The effect of fetal and perinatal asphyxia on familial frontotemporal dementia gene transcription as studied in a rat model. Melinda Barkhuizen (Maastricht, The Netherlands, Potchefstroom, South Africa/NL), Phyllis van der Ploeg, Fleur van Dijck, Kimberly Cox-Limpens (Maastricht, The Netherlands/NL), Daniel van den Hove (Maastricht, The Netherlands, Würzburg, Germany/NL), Harry Steinbusch, Boris Kramer (Maastricht, The Netherlands/NL), Danilo Gavilanes (Maastricht, The Netherlands, Guayaquil, Equador/NL)

P229 MAPT mutations and sporadic frontotemporal tauopathies: lost in translation? Shelley Forrest, Jillian Kril (Camperdown/AU), John Kwok (Randwick/AU), Maria Grazia Spillantini (Cambridge/GB), John Hodges, Glenda Halliday (Randwick/AU)

P230 Targeting the cytoskeleton in frontotemporal dementia Anna King, Nan Tian, Rachel Atkinson, James Vickers (Hobart/AU)

ICFTD 2016 Program September 1, 2016

P231 Clinical and pathological study of FTLD-FUS presenting chorea Ito Kawakami (Tokyo/JP), Tetsuaki Arai (Tokyo, Tsukuba/JP), Zen Kobayashi (Tokyo/JP), Osamu Yokota (Okayama/JP), Takashi Nonaka, Kazuhiro Niizato, Kenichi Oshima (Tokyo/JP), Shinji Higashi (Tokyo, Tsukuba/JP), Masato Hosokawa, Masato Hasegawa, Haruhiko Akiyama (Tokyo/JP)

P232 Clinicopathological correlation of frontotemporal dementia disorders Christer Nilsson, Christina Elfgren, Karin Nilsson, Ulla Passant, Alexander Frizell Santillo, Susanna Vestberg, Maria Landqvist Waldö, Danielle van Westen, Elisabet Englund (Lund/SE)

P233 pThr175 tau is associated with tau pathology in a spectrum of tauopathies Alexander Moszczynski, Wencheng Yang, Michael Strong (London/CA)

P234 An AAV9 mediated rat model of pThr175 tau protein toxicity Alexander Moszczynski, Jason Gopaul, Patrick Mccunn, Kathryn Volkening, Madeline Harvey, Robert Bartha, Susanne Schmid, Michael Strong (London/CA)

P235 pThr175 tau as a toxic phosphoepitope in CTE and ALSci Alexander Moszczynski (London/CA), Ann McKee (Boston/US), Wendy Strong, Michael Strong (London/CA)

P236 Selective vulnerability of the locus coeruleus in frontotemporal lobar degeneration (FTLD) with tau pathology David Irwin, Mathew Byrne, David Wolk, Edward Lee, Murray Grossman, John Trojanowski (Philadelphia/US)

P237 Prevalence of Amyloid pathology and PiB positivity in Frontotemporal dementia Rachel Tan (Randwick, Sydney/AU), Jillian Kril (Sydney/AU), Yue Yang (Randwick/AU), Olivier Piguet (Randwick, Sydney/AU), Lars Ittner (Sydney/AU), John Kwok, John Hodges, Glenda Halliday (Randwick, Sydney/AU)

P238 Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in Niemann- Pick Disease Type C Stefania Zampieri (Udine/IT), Sonia Canterini (Rome/IT), Kathy Newell (Kansas City, Kansas/US), Cristiana Stuani (Trieste/IT), Jill Murrell, Bernardino Ghetti (Indianapolis, Indiana/US), Maria Teresa Fiorenza (Rome/IT), Bruno Bembi (Udine/IT), Emanule Buratti (Trieste/IT), Andrea Dardis (Udine/IT)

P239 Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology Emma Clayton, Sarah Mizielinska (London/GB), James Edgar (Cambridge/GB), Troels Tolstrup Nielsen (Copenhagen/DK), Ida Holm (Randers, Aarhus/DK), Peter Johannsen, Jørgen Nielsen (Copenhagen/DK), Emmanuel Asante, John Collinge (London/GB), FReJA Consortium (Jutland/GB), Adrian Isaacs (London/GB)

P240 Pathological prediction in behavioral variant frontotemporal dementia David Perry, Jesse Brown, Katherine Possin, Andrew Trujillo, Anneliese Radke, Anna Karydas, Ana Sias, Gil Rabinovici, Maria Luisa Gorno-Tempini, Adam Boxer, Mary De May, Eric Huang, Katherine Rankin, Suzee Lee, Manu Sidhu, Stephanie Gaus, Jose Vargas, Rik Ossenkoppele, Alainna Brown (San Francisco, CA/US), Giovanni Coppola (Los Angeles, CA/US), Howard Rosen (San Francisco, CA/US), Daniel Geschwind (Los Angeles, CA/US), John Trojanowski (Philadelphia, PA/US), Lea Grinberg, Joel Kramer, Bruce Miller, William Seeley (San Francisco, CA/US)

ICFTD 2016 Program September 1, 2016

P241 TDP-43 Pre-Inclusions in Primary Progressive Aphasia: Morphology and Distribution Garam Kim, Zach Parton, Sandra Weintraub, Eileen Bigio, M.-Marsel Mesulam, Changiz Geula (Chicago/US)

P242 Sporadic FTLD TDP type C is a distinct clinicopathological entity from FTLD types A/B G Michael Baer, Matthew Byrne, Felicia Cooper, EunRan Suh, Leo McCluskey, Lauren Elman, David Wolk, Vivianna M. Van Deerlin, Virginia Lee, Edward Lee, Murray Grossman, John Trojanowski, David J. Irwin (Philadelphia/US)

P243 Tau aggregation and neurodegeneration predict regional atrophy and intrinsic connectivity disruption in progressive supranuclear palsy Salvatore Spina, Jesse A. Brown, Jersey Deng, Alissa Nana Li, Norbert Lee, Ji-Hye Hwang, Stephanie E. Gaus, Eric J. Huang, Adam Boxer, Howard J. Rosen, Bruce L. Miller, Lea Grinberg, William W. Seeley (San Francisco/US)

P244 TDP-43 Protein Pathology in Mouse Model's of Alzheimer's Disease Liam Kaylor (Aurora, Hobart/US)

P245 Disproportionate von Economo neuron and fork cell TDP-43 aggregation is associated with somatodendritic degeneration in sporadic behavioral variant FTD Alissa Nana, Manu Sidhu, Stephanie Gaus, Ji-Hye Hwang (San Francisco/US), Libo Li (San Francisco, Qiqihar/CN), Youngsoon Park, Eun-Joo Kim, Stephen DeArmond, Lea Grinberg, Eric Huang, Bruce Miller, William Seeley (San Francisco/US)

P246 Utility of Ubiquitin/p62 aggregates screening in granular neurons of the cerebellar cortex in a Brain Bank: experience of the Neurological Tissue Bank of the Biobanc- Hospital Clinic-IDIBAPS,Barcelona(Spain) Rainiero Avila (Sevilla, Barcelona/ES), Oscar Ramos, Oriol Grau, Anna Antonell, Albert Lladó, Raquel Sanchez-Valle (Barcelona/ES), Ellen Gelpi (Barcelona/BE)

P247 Hypertrophic microglia are associated with more tangles and less neurons in primary progressive aphasia with Alzheimer pathology Daniel Ohm, Alfred Rademaker, Eileen Bigio, M.-Marsel Mesulam, Emily Rogalski, Changiz Geula (Chicago/US)

P248 Biopsy in Dementia: A case report Catharina Prix, Johannes Levin (Munich/DE), Nibal Ackl (Munich, Münsterlingen/CH), Elisabeth Wlasich, Rupert Egensperger, Christoph Schwartz, Friedrich-Wilhelm Kreth, Armin Giese, Adrian Danek (Munich/DE)

P249 C9ORF72 in 3D: A Novel Dimension in FTD-MND iPSN Cultures Veronica Porterfield, Qing Zhong, Phylindia Gant, Erin Foff (Charlottesville/US)

P250 ER chaperones in the pathogenesis of amyotrophic lateral sclerosis (ALS) ANAND GOSWAMI, Alfred Yamoah, Alice Dreser (Aachen/DE), Dirk Troost (Amesterdam/NL), Joachim Weis (Aachen/DE)

P251 Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers Tania Gendron, Marka van Blitterswijk, Kevin Bieniek, Lillian Daughrity (Jacksonville/US), Jie Jiang (La Jolla/US), Beth Rush, Otto Pedraza, John Lucas, Melissa Murray, Pamela Desaro, Amelia Robertson, Karen Overstreet, Colleen Thomas, Julia Crook, Monica Castanedes-Casey, Linda Rousseau (Jacksonville/US), Keith Josephs, Joseph Parisi, David Knopman, Ronald Petersen, Bradley Boeve (Rochester/US), Neill Graff-Radford, Rosa Rademakers (Jacksonville/US), Clotilde

ICFTD 2016 Program September 1, 2016

Lagier-Tourenne (Charlestown/US), Dieter Edbauer (Munich/DE), Don Cleveland (La Jolla/US), Dennis Dickson, Leonard Petrucelli, Kevin Boylan (Jacksonville/US)

P252 Pick ‘n’ mix: neuropathological detection of peri-tumour tauopathy. Roisin Lonergan (Dublin/US), Vijay Ashankar, Fiona Carty, Michael Alexander, Peter Kelly, Killian O'Rourke, Michael Farrell, Tim Lynch (Dublin/IE)

12:00–14:00 Postersession II - Progressive aphasias Room Ballroom

P253 Eyes Reveal Semantic Deficit Early in Primary Progressive Aphasia Argye Hillis, David Race (Baltimore/US)

P254 Semantic dementia and the left and right temporal lobes Julie Snowden, Jennifer Harris, Jennifer Thompson, Christopher Kobylecki, Matthew Jones, Anna Richardson, David Neary (Manchester/GB)

P255 UK speech and language therapy services for Primary Progressive Aphasia (PPA): Referral patterns and barriers to access. Anna Volkmer, Jason Warren, Aimee Spector, Suzanne Beeke (London/GB)

P256 Dynamic perceptual ‘stress tests’ in primary progressive aphasia Chris Hardy, Rebecca Bond, Kankamol Jaisin, Charles Marshall, Camilla Clark, Lucy Russell, Jonathan Rohrer, Sebastian Crutch, Jason Warren (London/GB)

P257 Distinctive clinical presentations in Asian patients with left and right anterior temporal atrophy Amitabha Ghosh (Kolkata/IN), Ryuji Fukuhara (Kumamoto/JP), Adeline Ng Su Lyn (Singapore/SG), Jacqueline Dominguez (Manila/PH), Paulus Anam Ong (Bandung/ID), Aparna Dutt, Kishalaya Karan (Kolkata/IN), Manabu Ikeda (Kumamoto/JP)

P258 Functional neuroanatomy of speech signal decoding in primary progressive aphasias Chris Hardy, Charles Marshall, Camilla Clark, Lucy Russell, Emilie Brotherhood, David Thomas, Sebastian Crutch, Jonathan Rohrer, Jennifer Agustus, Jason Warren (London/GB)

P259 Progressive aphasias as disorders of auditory information processing: behavioural signatures and structural neuroanatomy Chris Hardy, Charles Marshall, Camilla Clark, Lucy Russell, Emilie Brotherhood, David Thomas, Sebastian Crutch, Jonathan Rohrer, Jennifer Agustus, Jason Warren (London/GB)

P260 Cross-sectional and longitudinal features of non-fluent/agrammatic primary progressive aphasia with underlying corticobasal degeneration or progressive supranuclear palsy pathology. Miguel Angel Santos-Santos, Maria Luisa Mandelli (San Francisco/US), Richard J. Binney (Philadelphia, San Francisco/US), Edoardo Spinelli (Milan, San Francisco/IT), Jennifer Ogar (San Francisco/US), Maya L. Henry (Austin, San Francisco/US), Isabel Hubbard (San Francisco/US), Stephen M. Wilson (Tuscon, San Francisco/US), John Q. Trojanowski (Philadelphia/US), Lea T. Grinberg, Howie Rosen, Adam L. Boxer, Bruce L. Miller, William W. Seeley, Maria Luisa Gorno-Tempini (San Francisco/US)

ICFTD 2016 Program September 1, 2016

P261 Grammatical dissociation in a Primary Progressive Aphasia patient: a prospective assessment Geraldine Borovinsky, Jesica Ferrari, Noelia Pontello, Juan Pablo Barreyro, Teresa Torralva, Facundo Manes, Macarena Martinez-Cuitiño (Buenos Aires/AR)

P262 Concreteness effect in a Semantic variant of Primary Progressive Aphasia patient: semantic processing and neuroanatomic areas Geraldine Borovinsky, Jesica Ferrari, Noelia Pontello (Buenos Aires/AR), Teresa Torralva (BUenos Aires/AR), Facundo Manes, Macarena Martinez-Cuitiño (Buenos Aires/AR)

P263 Distinct neural correlates underlying the relative preservation of episodic memory in semantic-variant PPA Muireann Irish, Steffie Bunk, Sicong Tu (Sydney/AU), Michael Hornberger (Sydney, Norwich/GB), John Hodges, Olivier Piguet (Sydney/AU)

P264 Focal Temporal Pole Atrophy and Network Degeneration in Semantic Variant Primary Progressive Aphasia Jessica Collins (Charlestown/US), Victor Montal (Barcelona/ES), Maria Luisa Gorno- Tempini (San Francisco/US), Brad Dickerson (Charlestown/US)

P265 Limited abstract word processing in behavioral variant frontotemporal degeneration Katheryn Cousins, Sharon Ash, Murray Grossman (Philadelphia/US)

P266 Patterns of hippocampal atrophy and memory loss among language subtypes of Frontotemporal dementia and Alzheimer’s disease Jagan Pillai, Aaron Bonner-Jackson, Michael Parsons, James Leverenz (Cleveland/US)

P267 Transcranial direct current stimulation as a potential therapy for symptoms of Primary Progressive Aphasia Nicole White, Felix Gervits, Sharon Ash, H. Branch Coslett, Roy Hamilton, Murray Grossman (Philadelphia/US)

P268 Neural Network Underlying Abnormal Syntax Processing in Primary Progressive Aphasia: Evidence from Resting State Functional Magnetic Resonance Imaging Borna Bonakdarpour, Allan Wang, Emily Rogalski, Robert Hurley, Marsel Mesulam (Chicago/US)

P269 Recognizing Primary Progressive Aphasia between Frontotemporal Dementia variants: Denomination mistakes like a tool for differential diagnosis Nathalia Rodriguez, María Del Pilar Mayorga Sierra, Diana Lucía Matallana Eslava (Bogotá/CO)

P270 Principal components analysis of neuropsychological features in nonfluent and logopenic variant PPA Jennifer Harris, Jennifer Adams, Matthew Jones, Anna Richardson, David Neary, Julie Snowden, Jennifer Thompson (Manchester/GB)

P271 Characterising Primary progressive Aphasia – a neuropsychological study Jennifer Harris, Jennifer Adams, Matthew Jones, Anna Richardson, David Neary, Julie Snowden, Jennifer Thompson (Manchester/GB)

P272 MRI in nonfluent and logopenic variant PPA: ASl, DTI and VBM Jennifer Harris, Jennifer Adams, Jennifer Thompson, Laura Parkes, Stephen Carter, Anna Richardson, David Neary, Julie Snowden, Matthew Jones (Manchester/GB)

ICFTD 2016 Program September 1, 2016

P273 Different biomarkers of neurodegeneration in the CSF distinguishing progressive non-fluent aphasia from other frontotemporal dementias Peter Koertvelyessy (Magdeburg/DE), Johannes Prudlo (Rostock/DE), Hans-Jochen Heinze, Daniel Bittner (Magdeburg/DE)

P274 Quantification of motor speech in primary progressive aphasia and frontotemporal dementia Matthew Poole (Parkville, Melbourne/AU), Amy Brodtmann, David Darby (Melbourne/AU), Adam Vogel (Parkville, Melbourne, Tubingen/AU)

P275 Apraxia profiles - A novel cognitive marker for differentiating clinical variants of FTLD and AD Andreas Johnen, Sophia Reul, Thomas Duning, Hubertus Lohmann (Münster/DE)

P276 PPA interventions with impact: Making everyone happy Regina Jokel (Toronto/CA)

P277 Artificial Grammar Learning in Vascular and Progressive Non-Fluent Aphasia Identifies Domain General Impairments. Thomas E Cope (Cambridge/GB), Benjamin Wilson (Newcastle/GB), Holly Robson (Reading/GB), Lauren Dean, Manon Grube (Newcastle/GB), Karalyn Patterson (Cambridge/GB), Timothy D Griffiths (Newcastle/GB), James B Rowe (Cambridge/GB), Chris Petkov (Newcastle/GB)

P278 PET-FLORBETAPIR FINDINGS IN PRIMARY PROGRESSIVE APHASIA. Alberto Villarejo, Sara Llamas-Velasco, Adolfo Gomez-Grande, Verónica Puertas- Martín, Pilar Sarandeses-Fernández, Marta Gonzalez-Sánchez, Sebastian Ruiz- Solis, Patrick Pilkington, David A. Pérez-Martínez, Alejandro Herrero-San Martín (Madrid/ES)

P279 Developing an international graded naming task. Ornella Billette (Magdeburg/DE), Zsolt Cséfalvay (Magdeburg/SK), Elisabeth Tute, Peter Nestor (Magdeburg/DE)

P280 Classifying primary progressive aphasias individually with support vector machine approaches in MRI data Sandrine Bisenius, Karsten Mueller (Leipzig/DE), Janine Diehl-Schmid (Munich/DE), Klaus Fassbender (Homburg/DE), Frank Jessen (Bonn/DE), Jan Kassubek (Ulm/DE), Johannes Kornhuber (Erlangen/DE), Anja Schneider (Goettingen/DE), Katharina Stuke (Leipzig/DE), Adrian Danek (Munich/DE), Markus Otto (Ulm/DE), Matthias L. Schroeter (Leipzig/DE), FTLD Study Group Germany (Ulm/DE)

P281 Electrostimulation effects in the logopenic and non-fluent variants of primary progressive aphasia Kyrana Tsapkini, Tushar Chakravarty, Bronte Ficek, Kim Webster, John Desmond, Chiadi Onyike, Constantine Frangakis, Argye Hillis (Baltimore/US)

P282 Verb regularization errors as an analogue for surface dyslexia in semantic dementia in languages with high grapheme-phoneme transparency Ornella Billette, Daniel Preiß, Peter Nestor (Magdeburg/DE)

P283 Aspects of natural conversation in primary progressive aphasia. Cathleen Taylor-Rubin (Waverley, Sydney, Sydney/AU), Karen Croot, Emma Power (Sydney/AU), Sharon A. Savage (Exeter/GB), John R. Hodges, Leanne Togher (Sydney/AU)

ICFTD 2016 Program September 1, 2016

P284 Semantic dementia with combined TDP-43 and FUS pathology Maria Landqvist Waldö, Christina Elfgren, Lars Gustafson, Ulla Passant (Lund/SE), Alexander Frizell Santillo (Malmö/SE), Elisabet Englund (Lund/SE)

P285 Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer’s disease Cristian Leyton, John Hodges, Olivier Piguet, Kirrie Ballard (Sydney/AU)

P286 Dissecting neurocognitive mechanisms underpinning sentence-processing deficits in PPA Cristian Leyton, John Hodges, Olivier Piguet, Kirrie Ballard (Sydney/AU)

P287 Convergent language network involvement in non-semantic PPA variants Cristian Leyton, Ramon Landin-Romero, Fiona Kumfor, James Burrell, John Hodges, Olivier Piguet (Sydney/AU)

P288 Domain Specific learning Disabilities within Atypical neurodenerative diseases primary progressive aphasia and Posterior Cortical atrophy Zachary Miller (San Francisco/US), Lynne Rosenberg (New York/US), Miguel Santos, Melanie Stephens, Maria Luisa Mandelli, Gil Rabinovici, Bruce Miller, Maria Luisa Gorno-Tempini (San Francisco/US)

P289 Lexical representation and parsing of morphologically complex words in non-fluent variant PPA and non-fluent post-stroke aphasia Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Gonia Jarema (Montréal/CA), Kyrana Tsapkini (Baltimore/US)

P290 Executive functions in non-fluent variant PPA: A comparison to non-fluent post-stroke aphasia Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Kyrana Tsapkini (Baltimore/US)

P291 The effect of verbal working memory capacity in sentence comprehension: A comparison between non-fluent post-stroke aphasia and non-fluent variant PPA Eleni Peristeri (Thessaloniki/GR), Ianthi-Maria Tsimpli (Cambridge/GB), Kyrana Tsapkini (Baltimore/US)

P292 Non-right handed primary progressive aphasia and apraxia of speech Hugo Botha, Jennifer Whitwell, Joseph Duffy, Edythe Strand, Mary Machulda, Val Lowe, Keith Josephs (Rochester/US)

P293 Neurochemical markers in the differential diagnosis of primary progressive aphasias: Data from the German FTLD consortium Patrick Oeckl, Sarah Anderl-Straub (Ulm/DE), Janine Diehl-Schmid (Munich/DE), Christine A.F. von Arnim (Ulm/DE), Klaus Fassbender (Homburg/DE), Emily Feneberg (Ulm/DE), Klaus Fliessbach (Bonn/DE), Hans Förstl (Munich/DE), Holger Jahn (Hamburg/DE), Bernhard Landwehrmeyer (Ulm/DE), Martin Lauer (Würzburg/DE), Johannes Levin (Munich/DE), Albert C. Ludolph (Ulm/DE), Johannes Prudlo (Rostock/DE), Anja Schneider (Göttingen/DE), Matthias Schroeter (Leipzig/DE), Elisa Semler, Petra Steinacker, Ingo Uttner (Ulm/DE), Jens Wiltfang (Göttingen/DE), Adrian Danek (Munich/DE), Markus Otto (Ulm/DE)

P294 Speech fluency as a tool to differentiate between FTLD variants. Angela Martínez (Bogotá, Lyon/CO), Diana Matallana (Bogotá/CO), Frédérique Gayraud (Lyon/FR)

ICFTD 2016 Program September 1, 2016

P295 Predicting rate of clinical decline using neuroimaging in progressive agrammatic aphasia and apraxia of speech Jennifer Whitwell, Stephen Weigand, Joseph Duffy, Heather Clark, Edythe Strand, Mary Machulda, Anthony Spychalla, Matthew Senjem, Clifford Jack, Keith Josephs (Rochester/US)

P296 Cross-cultural Adaptation of the Boston Diagnostic Aphasia Examination - Short Form in Filipino Howell Henrian Bayona (Taguig City, Manila, Philippines/PH), Ivan Paul Bondoc (Honolulu, Hawaii/US), Ellyn Loise Namoro, Fatima Faye Aclan, Alrenzo Ludwig Domingo (Manila, Philippines/PH), Jacqueline Dominguez (Taguig City/PH)

P297 Long-Term functional and behavior features of Primary Progressive Aphasia Syndrome. Ismael L Calandri, María Alejandra Amengual, Daiana Actis, Ricardo F Allegri (Buenos Aires/AR)

P298 Is the impairment on Luria three-step examination in FTD patients associated with language impairments? Linda Repetto, Peter Connick, Shuna Colville, Suvankar Pal, Thomas H. Bak (Edinburgh/GB)

P299 Different patterns of motor impairment in the behavioural and aphasic form of Frontotemporal Dementia Giulia Melchiorre, Peter Connick, Shuna Colville, Suvankar Pal, Thomas H Bak (Edinburgh/GB)

P300 Predictors of conversion to dementia in Primary Progressive Aphasia Laura Veronelli (Milan, Italy, Boston, MA/IT), Sara J. Makaretz, Megan Quimby (Boston, MA/US), Massimo Corbo (Milan, Italy/IT), Bradford C. Dickerson (Boston, MA/US)

P301 Distinctive profile of verbal fluency tasks and overall cognitive functioning in a Mexican sample in patients with frontotemporal dementia and Alzheimer's disease José Alberto Téllez Martínez, Juan Francisco Flores Vázquez, Gilberto Isaac Acosta Castillo, Airam Campos Jiménez, Loreli Álvarez Díaz, Adrian Martínez Ruíz, Ana Luisa Sosa Ortíz (México/MX)

P302 Assessment of frontal function and behavioral symptoms across subtypes of primary progressive aphasia, semantic dementia and progressive apraxia of speech Erin Golden (Rochester/GB), Hugo Botha, Joseph Duffy, Edythe Strand, Heather Clark, Mary Machulda, Jennifer Whitwell, Keith Josephs (Rochester/US)

P303 Cognitive and neuroanatomical features of amyloid positivity in primary progressive aphasia (PPA) Miguel Angel Santos-Santos, Gil D. Rabinovici, Nagehan Ayakta, Leonardo Iaccarino, Gautam Tammewar, Maya L. Henry, Andreas Lazaris, Zachary Miller, Maria Luisa Mandelli, Edoardo Spinelli, H. Isabel Hubbard, Howie Rosen, William Jagust, Bruce L. Miller, Lea T. Grinberg, William W. Seeley, Maria Luisa Gorno- Tempini (san francisco/US)

P304 Differentiating Frontotemporal Dementia Phenotypes in a Cinical Setting Using the Computerized Self-Test (CST) Monica Crane, Robert Anthony, Kevin Sellers, Kelly Knolton, John H. Dougherty (Knoxville/US)

ICFTD 2016 Program September 1, 2016

14:00–15:30 Session 6: CBS, PSP and MND Room Lecture Hall Chairs Günter Höglinger (Munich/DE), Albert Ludolph (Ulm/DE)

14:00 PSP & CBD: overlaps and distinctions within the FTLD spectrum Günter Höglinger (Munich/DE)

14:25 ALS - Pathology, genotype and phenoptype Albert Ludolph (Ulm/DE)

14:50 Plasma neurofilament light chain predicts disease progression in progressive supranuclear palsy O11 Julio Rojas, Anna Karydas, Jee Bang, Richard Tsai (San Francisco, CA/US), Kaj Blennow, Victor Liman (Gothenburg/SE), Joel Kramer, Howard Rosen, Bruce Miller (San Francisco, CA/US), Henrik Zetterberg (Gothenburg, London/SE), Adam Boxer (San Francisco, CA/US)

15:05 Converging Multimodal Evidence of Myelin Associated Proteins As Biomarkers in Four-Repeat Tauopathy O12 Corey McMillan, David Irwin, Matthew Byrne, Felicia Cooper, Kim Firn, Charles Jester, Eunran Suh, Vivianna Van Deerlin, John Trojanowski, Murray Grossman (Philadelphia/US)

15:20 Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta- analysis DB19 Zhangyu Zou, Chunhui Che, Changyun Liu, Huapin Huang (Fuzhou/CN)

15:22 [18F]AV-1451 PET imaging differentiates the tauopathies of Progressive Supranuclear Palsy (PSP) and Alzheimer’s disease (AD) DB20 Patricia Vazquez Rodriguez, Luca Passamonti (Cambridge/GB)

15:24 On The Clinical Overlap Between Progressive Supranuclear Palsy and Corticobasal Syndrome: evidence from the PiPPIN epidemiology study DB21 James Rowe, Ian Gilchrist (Cambridge/GB)

15:26 Clinical comparison of FTLD and ALS-FTD patients – is there a difference? DB22 Angela Rosenbohm, Raphael S Peter, Elisa Semler, Gabriele Nagel, Dietrich Rothenbacher, Markus Otto, Albert C Ludolph, ALS-FTLD Register Swabia Study Group (Ulm/DE)

16:00–17:30 Session 7: Biomarkers for FTLD Room Lecture Hall Chairs Markus Otto (Ulm/DE), Alessandro Padovani (Brescia/IT)

16:00 New physiological biomarkers of FTLD Jason Warren (London/GB)

16:25 Blood and CSF biomarkers in the presymptomatic stage of hereditary FTD John van Swieten (Rotterdam/NL)

ICFTD 2016 Program September 1, 2016

16:50 Data-driven Regions of Interest for Longitudinal Change in Three Variants of Frontotemporal Lobar Degeneration O13 Howard Rosen, Richard Binney, Aleksandr Pankov, Gabriel Marx, Faye McKenna, Xuanzie He, Adam Staffaroni, John Kornak, Suneth Attygalle, Adam Boxer, Norbert Schuff, Maria-Luisa Gorno-Tempini, Michael Weiner, Joel Kramer, Bruce Miller (San Francisco/US)

17:05 Multimodal imaging analysis of C9orf72-associated FTD in the Genetic Frontotemporal dementia Initiative (GENFI) study O14 Martina Bocchetta, Nicolas Toussaint, Michael Hutel, Marc Modat, M. Jorge Cardoso, Elizabeth Gordon, Katrina M Dick, David M Cash (London/GB), John van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti (Milan/IT), Mario Masellis (Toronto/CA), Caroline Graff (Huddinge, Stockholm/SE), Fabrizio Tagliavini (Milan/IT), Giovanni B Frisoni (Brescia/IT), Robert Laforce Jr (Québec City/CA), Elizabeth Finger (London Ontario/CA), Alexandre de Mendonça (Lisbon/PT), Sandro Sorbi (Florence/IT), Jason D Warren, Sebastien Ourselin, Jonathan D. Rohrer, on behalf of the Genetic FTD Initiative (GENFI) (London/GB)

17:20 Increased CSF levels of biomarkers for neurodegeneration in FTLD-GRN mutation carriers. DB23 Joery Goossens, Sara Van Mossevelde, Tobi Van den Bossche, Anne Sieben, Jean- Jacques Martin, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven, Julie van der Zee, Sebastiaan Engelborghs (Antwerp/BE)

17:22 Presymptomatic structural connectivity loss in familial frontotemporal dementia – a four year follow-up study of Dutch FTD pedigrees DB24 Lize Jiskoot, Jessica Panman, Elise Dopper, Janne Papma (Rotterdam/NL), Mark Bouts, Christiane Möller (Leiden/NL), Tom den Heijer, Rick van Minkelen (Rotterdam/NL), Serge Rombouts (Leiden/NL), John van Swieten (Rotterdam/NL)

17:24 Exosomal microRNAs in the cerebrospinal fluid as biomarkers in familial FTD DB25 Raphael Schneider, TaeHyung Kim, Paul McKeever (Toronto/CA), Caroline Graff (Stockholm/SE), John van Swieten (Rotterdam/NL), Robert Laforce Jr (Quebec City/CA), Daniela Galimberti (Milan/IT), Mario Masellis (Toronto/CA), Jonathan Rohrer (London/GB), Zhaolei Zhang, Janice Robertson, Maria Carmela Tartaglia (Toronto/CA)

17:26 Brain glucose metabolic abnormalities differ between predementia carriers of GRN and C9ORF72 mutations DB26 Claudia Jacova (Hillsboro/US), Ging-Yuek Robin Hsiung, Elham Shahinfard, Katie Dinelle, Pheth Sengdy, Siobhan McCormick, Vesna Sossi, A. Jon Stoessl, Howard Feldman, Ian R Mackenzie (Vancouver/CA)

19:00–00:00 Social Evening Room Hofbräukeller

ICFTD 2016 Program September 2, 2016

08:30–09:30 Session 8: Hot topics - Late breaking news Room Lecture Hall Chairs Glenda Halliday (Sydney/AU), Masato Hasegawa (Tokyo/JP)

08:30 Selected Talk (To be selected after Late breaking news abstract submission deadline)

08:45 Selected Talk (To be selected after Late breaking news abstract submission deadline)

09:00 A mouse model for FTD-like syndrome due to TREM2 mutations O15 Gernot Kleinberger, Benedikt Wefers, Marc Suárez-Calvet, Fargol Mazaheri (Munich/DE), Atanas Todorov (Basel/CH), Matthias Brendel (Munich/DE), Eva Mracsko (Basel/CH), Wolfgang Wurst (Munich/DE), Thomas Mueggler (Basel/CH), Axel Rominger (Munich/DE), Irene Knuesel (Basel/DE), Christian Haass (Munich/DE)

09:15 TDP-43 loss of function inhibits endosomal trafficking and alters signaling in neurons DB27 Benjamin Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin Schludi (Munich/DE), Daniel Hornburg, Felix Meißner (Martinsried/DE), Michael Peitz (Bonn/DE), Thomas Klopstock (Munich/DE), Albert Ludolph (Ulm/DE), Thomas Arzberger, Peer-Hendrik Kuhn, Dieter Edbauer (Munich/DE)

09:17 Neuronal Progranulin Overexpression Reverses Social Deficits in Progranulin- insufficient Mice DB28 Andrew Arrant, Anthony Filiano, Daniel Unger, Allen Young, Erik Roberson (Birmingham, AL/US)

09:19 Trehalose enhances progranulin expression in progranulin-deficient patient cells and mouse brain DB29 Christopher Holler, Georgia Taylor, Zachary McEachin, Qiudong Deng, William Watkins, Kathryn Hudson, Charles Easley, William Hu, Chadwick Hales, Wilfried Rossoll, Gary Bassell, Thomas Kukar (Atlanta/US)

09:21 Chloroquine rescues Cerebrospinal fluid progranulin deficiency in FTD DB30 Daniel Bittner, Peter Körtvelyessy, Hans-Jochen Heinze, Mandy Busse, Stefan Busse (Magdeburg/DE)

10:00–11:30 Session 9: Mechanisms of cell death Room Lecture Hall Chairs Dieter Edbauer (Munich/DE), Adrian Isaacs (London/GB)

10:00 Insights on motor neuron degeneration in a mouse model of TDP-43 proteinopathy Virigina Lee (Philadelphia, PA/US)

10:25 Insights from iPSC and Drosophila Models of C9ORF72‐ Related ALS/FTD O16 Fen-Biao Gao (Worcester/US)

10:40 Loss of TDP-43 Contributes to Non-coding RNA Mediated Toxicity O17 Elaine Liu, Jenny Russ, Edward Lee (Philadelphia/US)

ICFTD 2016 Program September 2, 2016

10:55 Fus regulates the transcriptome of the developing mouse brain through several mechanisms DB31 Chiara Valori (Tuebingen/DE), Cemil Kerimoglu (Göttingen/DE), Chieh-Yu Cheng, Vignesh Sakthivelu (Tuebingen/DE), Ronald Naumann (Dresden/DE), Andre Fischer (Göttingen/DE), Manuela Neumann (Tuebingen/DE)

10:57 Progranulin is neurotrophic in vivo, stimulating functional recovery after nerve crush injury DB32 Sander Beel, Louis De Muynck, Ludo Van Den Bosch, Wim Robberecht, Philip Van Damme (Leuven, Belgium/BE)

10:59 C9orf72 differential expression in brain and monocytes suggests a possible role for C9orf72 in monocyte function DB33 Emily Lynes, Patrizia Rizzu, Ashutosh Dhingra, Melissa Castillo-Lizardo, Margherita Franscescatto, Cornelis Blauwendraat, Sasja Heetveld, Elwira Pyz, Javier Simon- Sanchez, Matthis Synofzik, Peter Heutink (Tuebingen/DE)

11:01 RNA destabilization in frontotemporal lobar dementia and amyotrophic lateral sclerosis DB34 Hilary Archbold, Elizabeth Tank, Michelle Paulsen, Mats Ljungmann, Sami Barmada (Ann Arbor/US)

11:05 Panel discussion: What is the toxic species for C9FTD/ALS? Dieter Edbauer (Munich/DE), Adrian Isaacs (London/GB)

11:30–13:30 Postersession III - CBS, PSP, MND Room Ballroom

P305 PLS-FTLD, expanding the spectrum of dementia in motor neuron disease Michael van Es, Balint de Vries, Laura Rustemijer (Utrecht/NL), Anneke van der Kooi (Amsterdam/NL), Joost Raaphorst (Amsterdam, Nijmegen/NL), Carin Schroder, Tanja Nijboer, Joeren Hendrikse, Jan Veldink, Leonard van den Berg (Utrecht/NL)

P306 A voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) whole- brain analysis of gray matter and white matter changes in amyotrophic lateral sclerosis (ALS) without dementia Foteini Christidi, Efstratios Karavasilis, Sophia Xirou, Michael Rentzos, George Velonakis, Vasiliki Zouvelou, Ioannis Zalonis, Panagiotis Ferentinos, Loukia Poulou, Panagiotis Toulas, Thomas Zambelis, Nikolaos Karandreas, Nikolaos Kelekis, Ioannis Evdokimidis (Athens, Greece/GR)

P307 Impaired corticopontocerebellar tracts underlie pseudobulbar affect in motor neuron disorders Mary Kay Floeter, Rohan Katipally, Meridith Kim, Olivia Schanz, Matthew Stephen, Laura Danielian, Tianxia Wu (Bethesda, MD/US), Edward Huey (New York, NY/US), Avner Meoded (Bethesda, MD/US)

P308 Visuoperception test predicts pathologic diagnosis of Alzheimer disease in corticobasal syndrome Clara Boyd (New York, NY/US), Michael Tierney, Eric Wassermann (Bethesda, MD/US), Salvatore Spina, Adrian Oblak, Bernardino Ghetti (Indianapolis, IN/US), Jordan Grafman (Chicago, IL/US), Edward Huey (New York, NY/US)

ICFTD 2016 Program September 2, 2016

P309 Investigating progressive supranuclear palsy using VBM and SVM classification Karsten Mueller (Leipzig/DE), Robert Jech, Cecilia Bonnet, Jaroslav Tintěra (Prague/CZ), Harald E Möller (Leipzig/DE), Klaus Fassbender (Homburg/DE), Jan Kassubek, Markus Otto (Ulm/DE), Evžen Růžička (Prague/CZ), Matthias L Schroeter (Leipzig/DE)

P310 Genome-wide association study of plasma tau levels identifies risk variants for PSP and CBD Jin-Tai Yu, Jason Chen (San Francisco/US), Hui-Fu Wang (San Francisco/CN), Henrik Zetterberg, Kaj Blennow (San Francisco/SE), Jennifer Yokoyama, Michael Weiner, Joel Kramer, Howard Rosen, Bruce Miller, Giovanni Coppola, Adam Boxer (San Francisco/US)

P311 The sequence of progression of symptom domains in the PSP-Rating Scale (PSP- RS) Claire Brittain (Windlesham/GB), Michael Irizarry (Windlesham/US), Jeremie Lebrec (Windlesham/PT), Adam Boxer (San Francisco/US)

P312 Disentangling the neural correlates of corticobasal syndrome & corticobasal degeneration with systematic & quantitative ALE meta-analyses Franziska Albrecht, Sandrine Bisenius, Rodrigo Morales Schaack, Matthias Schroeter (Leipzig/DE)

P313 Rapid progression of brain atrophy in progressive supranuclear palsy and corticobasal degeneration Shubir Dutt (San Francisco/US), Richard Binney (San Francisco, Philadelphia/US), Hilary Heuer, Phi Luong, Suneth Attygalle, Priyanka Bhatt, Gabe Marx, Jonathan Elofson (San Francisco/US), Maria Carmela Tartaglia (Toronto/CA), Irene Litvan (San Diego/US), Scott McGinnis, Bradford Dickerson (Charlestown/US), John Kornak (San Francisco/US), Dana Waltzman (San Francisco, Stanford/US), Lisa Voltarelli, Norbert Schuff, Gil Rabinovici, Joel Kramer (San Francisco/US), Clifford Jack (Rochester/US), Bruce Miller, Adam Boxer (San Francisco/US)

P314 Cerebrospinal Fluid Phosphorylated Tau Associated with Survival in 4-Repeat Tauopathies Kim Firn, Leslie M. Shaw, David J. Irwin, Murray Grossman, Corey T. McMillan (Philadelphia/US)

P315 The relationship of iron accumulation to motor and cognitive performance in amyotrophic lateral sclerosis Nicola Spotorno, Julio Acosta-Cabronero, Judith Machts, Susanne Abdulla (Magdeburg/DE), Katja Kollewe, Susanne Preti (Hannover/DE), Stefan Vielhaber, Peter J. Nestor (Magdeburg/DE)

P316 Revised Clinical Diagnostic Criteria for Progressive Supranuclear Palsy (PSP) Günter Höglinger, Gesine Respondek (Munich/DE), Maria Stamelou (Neurology/GR), Carolin Kurz (Munich/DE), Keith Josephs (Rochester/US), Anthony Lang (Toronto/CA), Brit Mollenhauer (Kassel/DE), Ulrich Müller (Giessen/DE), Christer Nilsson (Lund/SE), Jennifer Whitwell (Rochester/US), Thomas Arzberger (Munich/DE), Ellen Gelpi (Barcelona/BE), Armin Giese (Munich/DE), David Irwin (Philadelphia/US), Wassilios Meissner (Bordeaux/FR), Alexander Pantelyat (Baltimore/US), John van Swieten (Rotterdam/NL), Claire Troakes (London/GB), Angelo Antonini (Venice/IT), Kailash Bhatia (London/GB), Yvette Bordelon (Los Angeles/US), Jean Christophe Corvol (Paris/FR), Carlo Colosimo (Roma/IT), Richard Dodel (Marburg/DE), Murray Grossman (Philadelphia/US), Jan Kassubek (Ulm/DE), Florian Krismer (Innsbruck/AT), Johannes Levin (Munich/DE), Huw Morris

ICFTD 2016 Program September 2, 2016

(London/GB), Peter Nestor (Magdeburg/DE), Wolfgang Oertel (Marburg/DE), Gil Rabinovici (San Francisco/US), James Rowe (Cambridge/GB), Thilo van Eimeren (Cologne/DE), Gregor Wenning (Innsbruck/AT), Jin-Tai Yu (San Francisco/US), Lawrence I. Golbe (New Brunswick/US), Irene Litvan (San Diego/US), Adam Boxer (San Francisco/US)

P317 Whole-brain pattern of iron-aware tissue magnetostatics in amyotrophic lateral sclerosis Julio Acosta-Cabronero, Judith Machts (Magdeburg/DE), Katja Kollewe (Hannover/DE), Susanne Abdulla (Magdeburg/DE), Susanne Petri (Hannover/DE), Stefan Vielhaber, Peter Nestor (Magdeburg/DE)

P318 PROGRESSIVE SUPRANUCLEAR PALSY IN THE SPECTRUM OF FRONTOTEMPORAL DEMENTIA: A NEUROPSYCHOLOGICAL AND NEUROIMAGING STUDY Leonardo Cruz de Souza, Elisa de Paula França Resende, Francisco Eduardo Costa Cardoso, Henrique Cerqueira Guimarães, Leandro Boson (Belo Horizonte/BR), Michael Hornberger, Maxime Bertoux (Norwich/GB), Paulo Caramelli, Antônio Lúcio Teixeira (Belo Horizonte/BR)

P319 H46R SOD1 mutation is consistently associated with a relatively benign form of Amyotrophic Lateral Sclerosis with very slow progression Zhangyu Zou (Fuzhou/CN), Mingsheng Liu, Xiaoguang Li, Liying Cui (Beijing/CN)

P320 Mutations in FUS are the most frequent genetic cause in juvenile sporadic ALS patients of Chinese origin Zhangyu Zou (Fuzhou/CN), Xiaoguang Li, Mingsheng Liu, Liying Cui (Beijing/CN)

P321 Predicting Disease Progression in Progressive Supranuclear Palsy in Multicenter Clinical Trials Jee Bang, Iryna Lobach (San Francisco/US), Anthony Lang (Toronto/CA), Murray Grossman (Philadelphia/US), David Knopman (Rochester/US), Bruce Miller (San Francisco/US), Lon Schneider (Los Angeles/US), Rachelle Doody (Houston/US), Andrew Lees (London/GB), Michael Gold (Research Triangle/US), Bruce Morimoto (Lincoln/US), Adam Boxer (San Francisco/US)

P322 Unusual sporadic 4R-tauopathy with bulbar onset MND-like syndrome preceding bvFTD Johannes Prudlo, Stefan Teipel, Andreas Buettner (Rostock/DE), Manuela Neumann (Tuebingen/DE)

P323 TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia Rachel Tan (Randwick, Sydney/AU), Matthew Kiernan, Jillian Kril (Sydney/AU), Masato Hasegawa, Masami Masada-Suzukake (Japan/JP), Carol Dobson-Stone, John Kwok (Randwick, Sydney/AU), Michael Hornberger (Norwich/GB), John Hodges, Glenda Halliday (Randwick, Sydney/AU)

P324 Loosing words and hand! A rare case of Semantic Dementia overlapping with Corticobasal Syndrome. Noémie MOREAU (Aix en Provence/FR), Marie LEGRAND (Pertuis/FR), Charlotte ROSEAU (Aix en Provence/FR), Guillaume PUIGSERVER (Pertuis/FR), Laurent RENIE, Bernadette BONNEFOI (Aix en Provence/FR)

ICFTD 2016 Program September 2, 2016

P325 Natural history and progression to dementia in progressive supranuclear palsy Andrea Pilotto (Brescia, Italy, Tuebingen, Germany/IT), Stefano Gazzina, Alberto Benussi, Marta Manes, Valentina Dell'Era, Maura Cosseddu, Rosanna Turrone, Barbara Borroni, Alessandro Padovani (Brescia, Italy/IT)

P326 DESCRIPTION OF PROGRESSIVE SUPRANUCLEAR PALSY SUBTYPES FROM THE NAVARRA BRAIN BANK Javier Sánchez Ruiz de Gordoa, María Victoria Zelaya Huerta, Teresa Tuñon Álvarez, Federico García Bragado, María Teresa Mendioroz Iriarte, Valle Coca Pueyo, Elena Erro Aguirre (Pamplona/ES)

P327 Joint analysis of GWAS with epigenetic data revealed candidate markers in FTD/MND, and convergence in pathways Erdogan Taskesen, Aniket Mishra, Danielle Posthuma, Yolande Pijnenburg (Amsterdam/NL)

P328 Multiple Pathologies and Heterogeneity in Corticobasal Syndrome and Corticobasal Degeneration: complications in a complex disease Rodrigo A. Santibanez (Vancouver, Santiago/CA), Ian R. Mackenzie, Michael Marnane, Shervin Mortazavi, Connor Keller, Jennifer Li, Angela Kim, Ging-Yuek R. Hsiung (Vancouver/CA)

P329 Disease-Specific Relationship Between Cerebrospinal Fluid & Longitudinal Neuroimaging Charles Jester, Kim Firn, Kylie Ternes, Leslie M Shaw, David Irwin, Dan Weintraub, Murray Grossman, Corey McMillan (Philadelphia/US)

P330 Creutzfeldt Jakob Disease (CJD) and Supranuclear Palsy (PSP) in one patient - two sides of the same medal? Felix Mueller-Sarnowski, Wiebke Valentin, Janine Diehl-Schmid (Munich/DE)

P331 The Edinburgh Cognitive and Behavioural ALS Screen (ECAS); the effect of age, education, and IQ. Monica Mariana De Icaza Valenzuela, Thomas Bak, Suvankar Pal, Sharon Abrahams (Edinburgh/GB)

P332 Serum neurofilament light chain (NfL) in Progressive Supranuclear Palsy (PSP) Laura Donker Kaat, Lieke Meeter, Agnita Boon, Wan Zeng Chiu, John van Swieten (Rotterdam/NL)

P333 Neuropathologic and Neurobiologic Characterization of Early Onset Amyotrophic Lateral Sclerosis Associated with a Novel TDP43 S375G Variant Kathy Newell (Kansas City/US), Bernardino Ghetti, Jill Murrell (Indianapolis/US), Maurizio Romano, Elisa Salis, Christiana Stuani, Emanuele Buratti (Trieste/IT)

P334 Social Cognition in Amyotrophic Lateral Sclerosis in an Argentinean-cohort. Preliminary Data. Federico Exequiel Nahas (Ciudad Autonoma de Buenos Aires, Buenos Aires/AR), Bruno De Ambrosi, Ismael Calandri, Fernanda Tapajoz, Patricia Zanuso, Martin Nogues (Ciudad Autonoma de Buenos Aires/AR), Ricardo Allegri (Ciudad Autonoma de Buenos Aires, Buenos Aires/AR)

ICFTD 2016 Program September 2, 2016

P335 Measuring Clinical and Cognitive Decline in CBD and PSP for Multicenter Clinical Trials – the 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI) Dan Luong, Lisa Voltarelli, Hilary Heuer, John Kornak (San Francisco/US), Kimiko Domoto-Reilly, Bradford Dickerson (Boston/US), Irene Litvan (San Diego/US), Maria Carmela Tartaglia (Toronto/CA), Bruce Miller, Adam Boxer (San Francisco/US)

11:30–13:30 Postersession III - Blood and Imaging biomarkers Room Ballroom

P336 IDENTIFYING CORTICAL ATROPHY IN THE MAIN VARIANTS OF FRONTO- TEMPORAL DEMENTIA, IN 48 COLOMBIAN PATIENTS: A VBM ANALYSIS Pablo Reyes, Maria Ortega, Santiago Gutierrez, Hernando Santamaría-García, Felipe Uriza, Diana Matallana (Bogotá/CO)

P337 The diffuse not focal frontal atrophy subtype shows worse prognosis in behavioral variant frontotemporal dementia Jin San Lee (Seoul/KR), Na-Yeon Jung, Eun-Joo Kim (Busan/KR), Juyoun Lee (Daejeon/KR), Young Kyoung Jang, Yeo Jin Kim, Hee Jin Kim, Sang Won Seo, Jae- Hong Lee (Seoul/KR), Byeong C. Kim (Gwangju/KR), Kyung-Won Park (Busan/KR), Soo Jin Yoon (Daejeon/KR), Jee H. Jeong (Seoul/KR), Sang Yun Kim (Seongnam/KR), Key-Chung Park (Seoul/KR), David S. Knopman (Rochester/US), Duk L. Na (Seoul/KR)

P338 Tau imaging in patients with ALS/PDC in the Kii Peninsula YASUMASA KOKUBO (Tsu/JP), Hitoshi Shinotoh, Hitoshi Shimada, Fumitoshi Niwa (Chiba/JP), Ryogen Sasaki, Satoru Morimoto (Tsu/JP), Hironobu Endo, Soichiro Kitamura, Shigeki Hirano (Chiba/JP), Ikuko Aiba (Nagoya/JP), Masanori Miyamura (Ise/JP), Naruhiko Sahara (Chiba/JP), Shigeki Kuzuhara (Suzuka/JP), Makoto Higuchi, Tetsuya Suhara (Chiba/JP)

P339 Analysis of regional MRI volumes and thicknesses on frontotemporal dementia patients with C9ORF72 expansion Ramona Haanpää, Yawu Liu, Anette Hall, Päivi Hartikainen (Kuopio/FI), Virpi Moilanen (Oulu/FI), Hilkka Soininen, Anne Remes (Kuopio/FI)

P340 Brain network organization in frontotemporal dementia across countries, recordings and methods Lucas Sedeño (BUENOS AIRES/AR), Olivier Piguet (Sydney/AU), Adolfo García, Sol Fitipaldi, Sofía Abrevaya, Indira García-Cordero, Sandra Baez, Laura Alethia de la Fuente (BUENOS AIRES/AR), Fiona Kumfor (Sydney/AU), Teresa Torralva (BUENOS AIRES/AR), John Hodges (Sydney/AU), Agustin Ibanez (BUENOS AIRES/AR)

P341 Frontotemporal dementia and language networks: cortical thinning is driven by dyslexia susceptibility genes Marta Antonia Manes, Donata Paternicò (Brescia/IT), Enrico Premi (Brescia/JM), Maura Cosseddu, Stefano Gazzina, Antonella Alberici (Brescia/IT), Silvana Archetti, Elisa Bonomi (Brescia,Italy/IT), Maria Sofia Cotelli, Marinella Turla, Maria Cotelli (Brescia, Italy/IT), Anna Micheli (Bergamo, Italy/IT), Roberto Gasparotti (Brescia, Italy/IT), Barbara Borroni, Alessandro Padovani (Brescia/IT)

ICFTD 2016 Program September 2, 2016

P342 A novel approach to investigate a rare Frontotemporal Disorder: proteomic studies about Nasu-Hakola Disease. Anna Maria Agresta, Antonella De Palma, Dario Di Silvestre (Segrate (Milan)/IT), Anna Maria Bardoni, Roberta Salvini, Paolo Iadarola (Pavia/IT), Pier Luigi Mauri (Segrate (Milan)/IT)

P343 Evolution of Cerebral PET Glucose Metabolism from presymptomatic to symtomatic Frontotemporal Dementia Linked to Chromosome 3 (FTD-3) – a voxel based SPM Analysis Peter Johannsen, Ian Law, Christian Hansen, Peter Roos, Jette Stokholm (Copenhagen/DK), Adrian M. Isaacs (London/GB), Jerry Brown (Cambridge/GB), Jorgen E. Nielsen (Copenhagen/DK)

P344 Tau [18F]AV-1451 PET Uptake in Patients with Suspected 4-Repeat Tauopathy Corey McMillan (Philadelphia/US), Daniel Schonhaut (San Francisco/US), David Russell (New Haven, CT/US), Adam Boxer (San Francisco/US), Irene Litvan (San Diego/US), Erik Roberson (Birmingham, AL/US), Ilya Nasrallah, Andrew Siderowf, Michael Devous, Murray Grossman (Philadelphia/US), Gil Rabinovici (San Francisco/US)

P345 In genetic frontotemporal dementia, functional network efficiency is maintained until the onset of symptoms: evidence for functional resilience to structural change Timothy Rittman, Robin Borchert, Simon Jones (Cambridge/GB), John Van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberta (Milan/IT), Mario Marsellis (Toronto/CA), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milan/IT), Giovanni Frisoni (Geneva/CH), Robert La Force (Quebec/CA), Elizabeth Finger (London/CA), Alexandre Mendonça (Lisbon/PT), Sandro Sorbi (Florence/IT), Jonathan Rohrer (London/GB), James Rowe (Cambridge/GB), on behalf of the Genetic FTD Initiative (GENFI) (London/GB)

P346 Disease-specific patterns of cortical and subcortical degeneration in a longitudinal study of Alzheimer's disease and behavioural-variant frontotemporal dementia Ramon Landin-Romero, Fiona Kumfor, Cristian Leyton, Muireann Irish, John Hodges, Olivier Piguet (Sydney/AU)

P347 White matter changes in frontotemporal dementia and the C9ORF72 gene expansions Ramon Landin-Romero (Sydney/AU), Bonnie Yin Ka Lam (Hong Kong/HK), Fiona Kumfor, Emma Devenney, Lauren Bartley, Glenda Halliday, John Hodges, Olivier Piguet (Sydney/AU)

P348 The synaptic protein neurogranin as a clinical CSF biomarker in the diagnosis of FTD Alexander Santillo, Shorena Janelidze, Joakim Hertze (Malmö/SE), Henrik Zetterberg (Mölndal/SE), Maria Landqvist Waldö (Lund/SE), Kaj Blennow (Mölndal/SE), Oskar Hansson (Malmö/SE)

P349 Different binding behavior of the Tau-PET tracer [F-18]-AV-1451 in AD and Tau- positive FTLD Jochen Hammes (Cologne/DE), Gérard N Bischof (Cologne, Jülich/DE), Klaus Fliessbach (Bonn/DE), Kathrin Giehl, Frank Jessen, Bernd Neumaier, Juraj Kukolja, Özgür Onur, Alexander Drzezga (Cologne/DE), Thilo van Eimeren (Cologne, Jülich/DE)

P350 Transcriptome analysis in FTD patients: genes, pathways and networks Wouter De Coster, Sara Van Mossevelde, Sebastiaan Engelborghs (Antwerp/BE), Mathieu Vandenbulcke (Edegem/BE), Ligia Mateiu, Maria Mattheijssens, Karin

ICFTD 2016 Program September 2, 2016

Peeters (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Patrick Cras (Antwerp, Edegem/BE), Peter Paul De Deyn (Antwerp, Groningen/BE), Marc Cruts, Christine Van Broeckhoven (Antwerp/BE)

P351 Neural network organization in frontotemporal degeneration by means of graph theory on resting-state EEG recordings: a study on behalf of the Italian FTD Network Laura Bonanni, Raffaella Franciotti (Chieti/IT), Alberto Benussi (Brescia/IT), Marco Bozzali (Rome/IT), Annachiara Cagnin (Padua/IT), Amalia Bruni (Lamezia Terme/IT), Silani Vincenzo (Milan/IT), Giancarlo Logroscino (Bari/IT), Roberta Ghidoni (Brescia/IT), Benedetta Nacmias (Florence/IT), Fabrizio Tagliavini (Milano/IT), Alessandro Padovani (Brescia/IT), Marco Onofrj (Chieti/IT), Daniela Galimberti (Milan/IT), Barbara Borroni (Brescia/IT)

P352 Characteristics and Progress on the Initial 256 Participants in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL) North American Rare Disease Clinical Research Consortium Adam Boxer, Howard Rosen (San Francisco/US), Brad Boeve (Rochester/US), Hilary Heuer, Samara Laxineta (San Francisco/US), Murray Grossman (Philadelphia/US), Giovanni Coppola (Los Angeles/US), Bradford Dickerson (Cambridge, MA/US), Yvette Bordelon (Los Angeles/US), Robin Conwit (Bethesda/US), Christina Dheel (Rochester/US), Kelley Faber (Indianapolis, IN/US), Howard Feldman (Vancouver/CA), John Ferguson (Bethesda/US), Julie Fields (Rochester/US), Jamie Fong (San Francisco/US), Tatania Foroud (Indianapolis, IN/US), Wendy Galpern (Washington, DC/US), Nupur Ghoshal (St. Louis/US), Neill Graff-Radford (Jacksonville, FL/US), Robin Hsiung (Vancouver/CA), Edward Huey (New York/US), David Irwin (Philadelphia/US), Kejal Kantarci (Rochester/US), Daniel Kaufer (Chapel Hill/US), Anna Karydas (San Francisco/US), Alex Klein (New York/US), David Knopman (Rochester/US), John Kornak, Joel Kramer (San Francisco/US), Walter Kukull (Seattle/US), Irene Litvan (San Diego/US), Ian Mackenzie (Vancouver/CA), Mario Mendez (Los Angeles, Baltimore, MD/US), Bruce Miller (San Francisco/US), Matthew Miller (Rochester/US), Chiadi Onyike, Alexander Pantelyat (Baltimore, MD/US), Rosa Rademakers (Jacksonville, FL/US), Erik Roberson (Jacksonville, FL, Birmingham/US), Margaret Sutherland (Bethesda/US), Maria Carmela Tartaglia (Toronto/CA), Nadine Tatton (Radnor, PA/US), Arthur Toga (Los Angeles/US), Ashley Vetor (Indianapolis, IN/US), Sandra Weintraub (Chicago/US), Zbigniew Wszolek (Jacksonville, FL/US)

P353 Grey Matter Disease Distributions in a Colombian Cohort of Patients with Frontotemporal Degeneration Pablo Reyes (Bogota/CO), Hernando Santamaría-Garcia (Bogota, Bogotá/CO), Felipe Uriza, Angela Martinez (Bogota/CO), Angela Iragorri, Diana Matallana, Jose Santacruz, Carlos Cano (Bogota, Bogotá/CO), Katya Rascovsky, Corey MacMillan, Murray Grossman (Philadelphia, PA/US)

P354 EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration. Joery Goossens (Antwerp/BE), Jorne Laton, Jeroen Van Schependom, Jeroen Gielen (Brussels/BE), Hanne Struyfs, Sara Van Mossevelde, Tobi Van den Bossche, Johan Goeman, Peter Paul De Deyn, Anne Sieben, Jean-Jacques Martin, Christine Van Broeckhoven, Julie van der Zee (Antwerp/BE), Guy Nagels (Brussels/BE), Sebastiaan Engelborghs (Antwerp/BE)

P355 The sAPPβ/YKL-40 ratio in cerebrospinal fluid as a novel diagnostic marker in frontotemporal lobar degeneration-related syndromes: a multicentre study Daniel Alcolea, Eduard Vilaplana, Marc Suárez-Calvet, Rafael Blesa, Jordi Clarimon (Barcelona, Madrid/ES), Albert Lladó, Raquel Sánchez-Valle, José L. Molinuevo

ICFTD 2016 Program September 2, 2016

(Barcelona/ES), Guillermo García-Ribas (Madrid/ES), Yaroslau Compta, María José Martí (Madrid, Barcelona/ES), Gerard Piñol-Ripoll (Lleida/ES), Guillermo Amer- Ferrer, Aina Noguera, Ana García-Martín (Palma de Mallorca/ES), Juan Fortea, Alberto Lleó (Barcelona, Madrid/ES)

P356 CSF exploratory biomarker study for (differential) diagnosis of frontotemporal lobar degeneration. Joery Goossens, Julie van der Zee (Antwerp/BE), Sara Van Mossevelde (Antwerp, Edegem/BE), Eugeen Vanmechelen (Ghent/BE), Tobi Van den Bossche (Antwerp, Edegem/BE), Bart De Vil, Anne Sieben, Jean-Jacques Martin (Antwerp/BE), Patrick Cras (Edegem, Antwerp/BE), Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven, Sebastiaan Engelborghs (Antwerp/BE)

P357 Dynamic connectivity state oscillations in presymptomatic GRN disease: from Connectome to Chronnectome. Enrico Premi (Brescia/JM), Matteo Diano (Turin/IT), Stefano Gazzina (Brescia/IT), Franco Cauda (Turin/IT), Silvana Archetti, Roberto Gasparotti, Alessandro Padovani, Barbara Borroni (Brescia/IT)

P358 Structural deficits and altered network connectivity in presymptomatic C9ORF72 Suzee Lee, Ana C. Sias, Maria Luisa Mandelli, Jesse A. Brown, Alainna B. Brown (San Francisco/US), Anna M. Khazenzon (Stanford/US), Anna A. Vidovszky, Theodore P. Zanto, Anna M. Karydas (San Francisco/US), Mochtar Pribadi, Giovanni Coppola, Dan H. Geschwind (Los Angeles/US), Rosa Rademakers (Jacksonville/US), Maria Luisa Gorno-Tempini, Howard J. Rosen, Bruce L. Miller, William W. Seeley (San Francisco/US)

P359 Longitudinal decline of cerebral glucose metabolism in Frontotemporal Lobar Degeneration Continuum Alexandre Bejanin, Nagehan Ayakta, Daniel R Schonhaut, Gabe Marx, Gautam Tammewar, Yann Cobigo, Faye McKenna, Leonardo Iaccarino, Marilu Gorno- Tempini, Bruce L. Miller, William J. Jagust, Howard J. Rosen, Gil D. Rabinovici (San Francisco/US)

P360 Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia Ione Woollacott, Jonathan Rohrer, Katrina Dick, Emilie Brotherhood, Elizabeth Gordon, Alexander Fellows, Jamie Toombs, Ronald Druyeh, M. Jorge Cardoso, Sebastien Ourselin, Jennifer Nicholas (London/GB), Niklas Norgren (Umea/SE), Simon Mead (London/GB), Ulf Andreasson, Kaj Blennow (Gothenburg/SE), Jonathan Schott, Nick Fox, Jason Warren (London/GB), Henrik Zetterberg (London, Gothenburg/SE)

P361 Default, salience, and executive control network functional connectivity changes in behavioural variant FTD and Alzheimer’s disease Juan Wang, Adeline Ng, Joseph Lim, Boon Linn Choo, Christabel See, Levinia Lim, Ting Ting Yong, Russell Chander, Heidi Foo, Angeline Zhang, Joanna Su, Ashwati Vipin, Simon Ting, Shahul Hameed, Nagaendran Kandiah, Helen Zhou (Singapore/SG)

P362 Principal Component Analysis of [18F]-AV-1451 Tau PET in Alzheimer Disease and Frontotemporal Dementia Karl Friedrichsen, Shruti Mishra, Nupur Ghoshal, Brian Gordon, Nelly Joseph- Mathurin, Yi Su, Jon Christensen, Patricia Aldea, Jon McConathy, Beau Ances, Nigel Cairns, John Morris, Tammie Benzinger (Saint Louis/US)

ICFTD 2016 Program September 2, 2016

P363 Grey matter network differences between behavioural variant Frontotemporal Dementia and Alzheimer’s disease Everard Vijverberg (Amsterdam, The Hague/NL), Betty Tijms, Joana Dopp, Yun Jeong Hong, Philip Scheltens, Frederik Barkhof, Yolande Pijnenburg (Amsterdam/NL)

P364 The REGISTRY FOR EARLY-ONSET DEMENTIA AND CAREGIVERS IN HONG KONG (REACH) study – clinical characteristics of FTD patients in Hong Kong Bonnie Yin Ka Lam, Lisa Wing Chi Au, Adrian Wong, Valerie Wong, Lorraine Law, Liz Yuen, Vincent Chung Tong Mok (Hong Kong/HK)

P365 Distinct subcortical atrophy patterns across four different neurodegenerative syndromes Julia Neitzel, Mallissa Watts, Janine Diehl-Schmid, Marion Ortner, Timo Grimmer, Igor Yakushev (Munich/DE), Peter Bublak, Christoph Preul (Jena/DE), Kathrin Finke, Christian Sorg (Munich/DE)

P366 Testing the network degeneration hypothesis for intrinsic brain networks and four distinct neurodegenerative syndromes Julia Neitzel (Munich/DE), Mallissa Watts, Janine Diehl-Schmid, Marion Ortner, Timo Grimmer, Igor Yakushev (Munich/DE), Peter Bublak, Christoph Preul (Jena/DE), Kathrin Finke, Christian Sorg (Munich/DE)

P367 Neurofilament light chain: a biomarker for disease onset and survival in genetic frontotemporal dementia Lieke Meeter, Elise Dopper, Lize Jiskoot (Rotterdam/NL), Raquel Sanchez-Valle (Barcelona/ES), Caroline Graff (Stockholm/SE), Luisa Benussi, Roberta Ghidoni (Brescia/IT), Yolande Pijnenburg (Amsterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti (Milano/IT), Robert Jr Laforce (Québec/CA), Mario Masellis (Toronto/CA), Rik Vandenberghe (Leuven/BE), Isabelle Le Ber (Paris/FR), Markus Otto (Ulm/DE), Rick van Minkelen, Janne Papma (Rotterdam/NL), Serge Rombouts (Leiden/NL), Mircea Balasa (Barcelona/ES), Linn Öijerstedt, Vesna Jelic (Stockholm/SE), David Cash, Sophie Harding, M Jorge Cardoso, Sebastien Ourselin, Katrina Dick, Martin Rossor (London/GB), Giuliano Binetti, Alessandro Padovani (Brescia/IT), Elio Scarpini, Chiara Fenoglio (Milano/IT), Carmela Tartaglia (Toronto/CA), Foudil Lamari (Paris/FR), Christian Barro, Jens Kuhle (Basel/CH), Jonathan Rohrer (London/GB), Charlotte Teunissen (Amsterdam/NL), John van Swieten (Rotterdam, Amsterdam/NL)

P368 Novel CSF biomarkers discriminating FTLD-TDP from non-demented controls. Marta del Campo, Naura Elias, Marleen Koel-Simmelink, Lynn Boonkamp (Amsterdam/NL), Daniela Galimberti (Milan/IT), William Hu (Atlanta/US), Charlotte Teunissen (Amsterdam/NL)

P369 Analysis of Frontotemporal Lobar Degeneration Patients Using Automated Magnetic Resonance Imaging Analyzing Tool: The MRI Characteristics of C9ORF72 Expansion Carriers Antti Cajanus, Anette Hall, Yawu Liu (Kuopio/FI), Timo Urhemaa, Juha Koikkalainen (Tampere/FI), Daniel Rueckert (London/GB), Steen Hasselbalch (Copenhagen/DK), Patrizia Mecocci (Perugia/IT), Wiesje van der Flier (Amsterdam/NL), Hilkka Soininen (Kuopio/FI), Jyrki Lötjönen (Tampere/FI), Anne Remes (Kuopio/FI)

ICFTD 2016 Program September 2, 2016

P370 Accelerated Structural Gray Matter and White Matter Changes in Preclinical Progranulin Mutation Carriers Christopher Olm, Corey McMillan, David Irwin, Vivianna Van Deerlin, James Gee, Murray Grossman (Philadelphia/US)

P371 Local thalamic atrophy in behavioural variant FTD Alexander Santillo (Malmö/SE), David Jakabek (Wollongong/AU), Mark Walterfang (Melbourne/AU), Karin Nilsson, Danielle van Westen (Lund/SE), Jeffrey Looi (Canberra/AU), Brian Power (Fremantle/AU)

P372 STRUCTURAL BRAIN IMAGING DIFFERENTIATES BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA FROM LATE LIFE DEPRESSION Duygu Tosun, Howard Rosen, Jessica Zakrzewski, Bruce Miller, Joel Kramer, Michael Weiner, Owen Wolkowitz, Craig Nelson, Scott Mackin (San Francisco/US)

P373 DIAGNOSTIC UTILITY OF ARTERIAL SPIN LABELED MAGNETIC RESONANCE IMAGING AND FLOURODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY IN THE BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA AND ALZHEIMER’S DISEASE Duygu Tosun, Norbert Schuff, Gil Rabinovici, Nagehan Ayakta, Bruce Miller (San Francisco/US), William Jagust (Berkeley/US), Joel Kramer, Michael Weiner, Howard Rosen (San Francisco/US)

P374 Replication of pathology-confirmed atrophy patterns via cortical thickness analysis in dementia Jee Hoon Roh, Jihye Hwang, Chan Mi Kim, Sohee Park, Jae-Hong Lee (Seoul/KR)

P375 Neuroanatomic and Neuropsychological Evidence of Cognitive Reserve in the ALS- FTD spectrum Katerina Placek, Kylie Ternes, Lauren Massimo, John Woo, Lauren Elman, David Irwin, Murray Grossman, Corey T. McMillan (Philadelphia/US)

P376 Alteration of the brain morphometry and metabolism following donepezil treatment in Alzheimer's disease: VBM with DARTEL and 1H-MR spectroscopy Gwang-Woo Jeong, Choong-Man Mooon (Gwang-Ju/KR)

P377 Progranulin plasma levels predict the presence of GRN mutations but not the development of symptoms Daniela Galimberti, Chiara Fenoglio, Sara Cioffi, Giorgio Fumagalli, Andrea Arighi (Milan/IT), Barbara Borroni, Alessandro Padovani (Brescia/IT), Fabrizio Tagliavini (Milan/IT), Mario Masellis, Carmela Tartaglia (Toronto/CA), John Van Swieten, Lieke Meeter (Rotterdam/NL), Caroline Graff (Stockholm/SE), Alexandre Mendonca (Lisbon/PT), Jonathan Rohrer (London/GB), Elio Scarpini (Milan/IT), on behalf of the Genetic Initiative (GENFI) (London/GB)

P378 Regional differences in FDG-PET uptake in asymptomatic FTD patients with GRN and C9ORF72 mutations Karteek Popuri, Mahadev Bhalla, Adrienne Buller, Sohrab Towfighi (Burnaby/CA), Pheth Sengdy (Vancouver/CA), Claudia Jacova (Oregon/US), Rosa Rademakers (Jacksonville/US), Howard Feldman (Vancouver/CA), Lei Wang (Chicago/US), Ging- Yuek Hsiung, Ian R Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)

P379 Network measures of glucose metabolism are altered in asymptomatic FTD subjects Karteek Popuri, Mahadev Bhalla, Adrienne Buller, Sohrab Towfighi (Burnaby/CA), Pheth Sengdy (Vancouver/CA), Claudia Jacova (Oregon/US), Rosa Rademakers

ICFTD 2016 Program September 2, 2016

(Jacksonville/US), Howard Feldman (Vancouver/CA), Lei Wang (Chicago/US), Ging- Yuek Hsiung, Ian R Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)

P380 Network-level analysis of cortical gray matter atrophy in asymptomatic FTD subjects Karteek Popuri, Mahadev Bhalla, Adrienne Buller, Sohrab Towfighi (Burnaby/CA), Pheth Sengdy (Vancouver/CA), Rosa Rademakers (Jacksonville/US), Howard Feldman, Ging-Yuek Hsiung (Vancouver/CA), Lei Wang (Chicago/US), Ian R Mackenzie (Vancouver/CA), Mirza Faisal Beg (Burnaby/CA)

P381 Distinct patterns of brain atrophy in genetic frontotemporal dementia: visual rating scales in the GENFI cohort Giorgio Giulio Fumagalli, Paola Basilico (Milan/IT), Sophie Harding (London/GB), Andrea Arighi (Milan/IT), Martina Bocchetta (London/GB), Matteo Mercurio (Milan/IT), Katrina Dick (London/GB), John van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT), Caroline Graff (Stockholm/SE), Mario Masellis (Toronto/CA), Fabrizio Tagliavini (Milan/IT), James Rowe (Cambridge/GB), Robert Laforce (Quebec/CA), Elizabeth Finger (London Ontario/CA), Giovanni Frisoni (Brescia/IT), Alexandre Mendoca (Lisbon/PT), Sandro Sorbi (Florence/IT), Elio Scarpini (Milan/IT), Jonathan Rohrer (London/GB), Daniela Galimberti (Milan/IT)

P382 Comparison of diagnostic significance of voxel-based diffusion tensor imaging and FDG-PET in bvFTD Gero Lueg, Julia Julia Lange-Grumfeld, Alexis Vrachimis, Hubertus Lohmann, Andreas Johnen, Thomas Duning (Münster/DE)

P383 Novel Connectome Approach Identifies Imaging-Genetic Associations in Sporadic Frontotemporal Degeneration Radhika Madhavan (Bangalore/IN), Asha Singanamalli (Niskayuna/US), Rakesh Mullick, Vivek Vaidya (Bangalore/IN), Chinnappa Kodira (Niskayuna/US), Vivianna Van Deerlin, Murray Grossman, David Irwin, Corey McMillan (Philadelphia/US)

P384 Altered expression of non-coding RNAs in neural-derived serum exosomes in patients with FTD Chiara Fenoglio, Maria Serpente, Sara Cioffi, Marina Arcaro, Emanuela Oldoni, Giorgio Fumagalli, Andrea Arighi, Paola Basilico, Alessandra Cattaneo, Laura Porretti, Daniela Galimberti, Elio Scarpini (Milan/IT)

P385 Autosomal Dominant and sporadic Frontotemporal Lobar Degeneration: from non- coding RNAs to the identification of preclinical biomarkers and therapeutic targets Maria Serpente, Chiara Fenoglio, Sara Cioffi, Marina Arcaro, Emanuela Oldoni, Andrea Arighi, Giorgio Fumagalli, Elio Scarpini, Daniela Galimberti (Milan/IT)

P386 In vivo molecular imaging of beta-amyloid and tau aggregates in monozygotic twins with discordant clinical phenotypes Ryan Townley, David Jones, Bradley Boeve, David Knopman, Ronald Peterson, Val Lowe, Clifford Jack (Rochester/US)

P387 CSF neurofilament-light chain and p-Tau180/t-Tau for discrimination of frontotemporal lobar degeneration pathology subtypes Julio Rojas, Carole Scherling, Anna Karydas, Joel Kramer, Howard Rosen, Gil Rabinovici, Zachary Miller, Bruce Miller, Adam Boxer (San Francisco, CA/US)

P388 18F-AV-1451 in frontotemporal dementia spectrum disorders Richard Tsai, Alexandre Bejanin (San Francisco/US), Daniel Schonhaut (San Francisco, Berkeley/US), Rik Ossenkoppele (Amsterdam/NL), James O'Neil, Mustafa Janabi, Suzanne Baker (Berkeley/US), Andreas Lazaris (San Francisco/US),

ICFTD 2016 Program September 2, 2016

Nagehan Ayakta, Gautam Tammewar (San Francisco, Berkeley/US), Marilu Gorno- Tempini, Bruce Miller, Adam Boxer (San Francisco/US), William Jagust (Berkeley/US), Gil Rabinovici (San Francisco, Berkeley/US)

P389 Differential Longitudinal Decline of White Matter Integrity in Frontotemporal Lobar Degeneration and Alzheimer’s Disease Gabriel Marx, Fanny Elahi, Howie Rosen (Oakland/US)

P390 Patient-tailored disease epicenters in behavioral variant frontal temporal dementia and semantic variant primary progressive aphasia Jesse Brown, Jersey Deng, Isabel Sible, Ana Sias, Suzee Lee, Marilu Gorno- Tempini, Howard Rosen, Bruce Miller, William Seeley (San Francisco/US)

P391 Atlas-based volumetric MRI analysis of c9orf72 mutation carriers Sonja Schönecker, Christiane Neuhofer, Janine Diehl-Schmid, Markus Otto, Catharina Prix (Munich/DE), German FTLD-Consortium (Germany/DE), Bavarian Brain Banking Alliance (Bavaria/DE), Thomas Arzberger, Dieter Edbauer, Berend Feddersen, Thomas Klopstock, Johannes Levin (Munich/DE)

P392 Blood markers of neuroinflammation in frontоtemporal dementia Nataliya Mikhaylova, Lubov Androsova, Svetlana Zozulya, Yana Fedorova, Igor Kolykhalov, Tatiyana Kliushnik (Moscow/RU)

P393 Results from the Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI) Howard Rosen (San Francisco/US), David Knopman (Rochester/US), Bradford Dickerson (Boston/US), Brad Boeve (Rochester/US), Marissa Urbano, Alyssa Caplan, Samara Laxineta, Bruce Miller (San Francisco/US)

P394 Decreased prefrontal cortex and posterior cingulate activation during matrix reasoning in asymptomatic carriers of GRN mutations Courtney Alexander (Hillsboro/US), Dasa Zeithamova (Eugene/US), Ging-Yuek R. Hsiung, Ian Mackenzie (Vancouver/CA), Claudia Jacova (Hillsboro/US)

P395 Comparison of [18F]T807 PET regional retention patterns in FTLD-tau and FTLD- TDP Charles Burke, Namita Multani, Karen Misquitta, Pablo Rusjan, Alan Wilson, Sylvain Houle, David Tang-Wai, Maria Carmela Tartaglia (Toronto/CA)

P396 Patterns of longitudinal neuroanatomical change in genetic FTD: results from the Genetic FTD Initiative (GENFI) Jonathan Rohrer, Martina Bocchetta, Elizabeth Gordon, David Cash, Katrina Dick, David Thomas, Jennifer Nicholas, M Jorge Cardoso, Sebastien Ourselin (London/GB), John van Swieten (Rotterdam/NL), Barbara Borroni (Brescia/IT), Daniela Galimberti (Milano/IT), Mario Masellis (Toronto/CA), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milano/IT), Giovanni Frisoni (Brescia/IT), Robert Laforce Jr (Quebec/CA), Elizabeth Finger (London Ontario/CA), Alexandre Mendonca (Lisboa/PT), Sandro Sorbi (Firenze/IT), Martin Rossor (London/GB)

P397 A case of Wilson’s disease presenting with depression as the initial symptom. Hyuk Chang, Hyunyoung Park, JinSung Cheong (Iksan/KR)

P398 A Patient with Frontotemporal Dementia Presenting with Unilateral Apraxia. Hyunyoung Park, Hyuk Chang, JinSung Cheong (Iksan/KR)

ICFTD 2016 Program September 2, 2016

P399 DTI changes in individuals with Primary Progressive Aphasia Daniel Preiß, Ornella Billette, Julio Acosta-Cabronero, Peter Nestor (Magdeburg/DE)

P400 Clinical, genetic and pathological stratification in frontotemporal dementia: implications for clinical trial design. Elizabeth Gordon, Martina Bocchetta, M. Jorge Cardoso, Sebastien Ourselin, Jason D. Warren, Jonathan D. Rohrer (London/GB)

P401 Computational modelling of combined M/EEG in FTD: layer specific insights into altered neurobiology during the auditory mismatch negativity. Alexander Shaw, Laura Hughes, James Rowe (Cambridge/GB)

P402 Frailty correlates with insula hypometabolism and frontal cortex atrophy in bvFTD Innocenzo Rainero, Martina Amanzio, Federico D'Agata, Antonello Galati, Sara Palermo, Elisa Rubino, Milena Zucca, Lorenzo Pinessi, Giancarlo Castellano (Turin/IT)

P403 Phenomenology and anatomy of abnormal behaviours in frontotemporal dementia as measured by the Cambridge Behavioural Inventory Elizabeth Gordon, Jason D. Warren, Jonathan D. Rohrer (London/GB)

P404 Alteration in plasma lipids in frontotemporal dementia Woojin Kim, Eve Jary, Russell Pickford, Lauren Bartley, Olivier Piguet, John Hodges, Glenda Halliday (Sydney/AU)

P405 [18F]AV1451 PET in frontotemporal dementia from a MAPT mutation William Bevan-Jones, Thomas Cope, Luca Passamonti, Timothy Fryer, Young Hong, Simon Jones, Jonathan Coles, Patricia Vazquez Rodriguez, Ajenthan Surendranathan, Robert Arnold, Franklin Aigbirhio, John O'Brien, James Rowe (Cambridge/GB)

P406 The Inverse Cingulate Island Sign in Hippocampal Sclerosis Dementia Will Mantyh, David Knopman, Jonathan Graff-Radford (Rochester/US), Melissa Murray, Dennis Dickson (Jacksonville/US), David Jones (Rochester/US)

P407 Serum neuron-specific enolase is increased in mild neurocognitive disorder / mild cognitive impairment and related to white matter hyperintensities Maryna Polyakova, Katrin Arelin, Leonie Lampe, Francisca Then, Tobias Luck, Jürgen Kratzsch, Karl-Titus Hoffmann, Steffi Rieder-Heller, Arno Villringer, Peter Schoenknecht, Matthias L. Schroeter (Leipzig/DE)

P408 Can Neuroimaging Measures of Hippocampal Structure Predict Alzheimer's vs. FTLD Neuropathologies? Lei Wang, Veronika Hanko, Kathryn Alpert, Julie Schneider, Konstantinos Arfanakis, David Bennett (Chicago/US)

P409 [18F]AV1451 PET imaging in Semantic Dementia William Bevan-Jones, Thomas Cope, Luca Passamonti, Patricia Vazquez Rodriguez, Ajenthan Surendranathan, Robert Arnold, Simon Jones, Timothy Fryer, Young Hong, Jonathan Coles, Franklin Aigbirhio, John O'Brien, James Rowe (Cambridge/GB)

P410 Presymptomatic changes in gray matter volume, white matter integrity and neuropsychological assessment in C9orf72 mutation carriers Jessica L. Panman (Rotterdam, Leiden/NL), Lize C. Jiskoot, Elise G.P. Dopper (Rotterdam, Leiden, Amsterdam/NL), Serge A.R.B. Rombouts (Leiden/NL), Tom den Heijer, Sanne Franzen (Rotterdam/NL), Yolande A.L. Pijnenburg (Amsterdam/NL),

ICFTD 2016 Program September 2, 2016

Rick van Minkelen, Janne M. Papma (Rotterdam/NL), John C. van Swieten (Rotterdam, Amsterdam/NL)

P411 Tau PET, Amyloid PET, and Structural Imaging in Primary Progressive Aphasia Adam Martersteck, M.-Marsel Mesulam, Emily Rogalski (Chicago/US)

P412 PET Tau Imaging with AV-1451 in N279K and S305N Microtubule Associated Protein Tau (MAPT) Mutation Carriers Relative to Alzheimer’s Disease Dementia and Controls Brad Boeve, David Jones, Val Lowe, Heather Wiste, Matthew Senjem, Kejal Kantarci, David Knopman, Christina Dheel (Rochester/US), Zbigniew Wszolek, Rosa Rademakers (Jacksonville/US), Ronald Petersen, Clifford Jack, Jr. (Rochester/US)

P413 Neurofilament light chain protein concentration in CSF and atrophy are correlated in bvFTD patients – Data from the multicentric FTLD consortium’s study Sebastian Meyer, Karsten Mueller, Sandrine Bisenius (Leipzig/DE), Janine Diehl- Schmid (Munich/DE), Hans Foerstl (Leipzig, Munich/DE), Klaus Fassbender (Homburg/DE), Jan Kassubek, Bernhard Landwehrmeyer, Albert Christian Ludolph (Ulm/DE), Johannes Kornhuber (Erlangen/DE), Johannes Prudlo (Rostock/DE), Anja Schneider (Goettingen/DE), Katharina Stuke, Matthias Schroeter (Leipzig/DE)

P414 Evolution from the Asymptomatic to Symptomatic State in Familial FTD: Longitudinal Neuropsychological and MRI Findings in Three MAPT Mutation Carriers Christina Dheel, Scott Przybelski, Matthew Senjem, Kejal Kantarci, David Jones, Julie Fields, Mary Machulda, Clifford Jack, Jr. (Rochester/US), Rosa Rademakers (Jacksonville/US), David Knopman (Rochester/US), Zbigniew Wszolek (Jacksonville/US), Ronald Petersen, Bradley Boeve (Rochester/US)

P415 Neurofilament light chain, progranulin, and S-100B in longitudinal serum samples of patients with amyotrophic lateral sclerosis Petra Steinacker, André Huss, Benjamin Mayer, Patrick Oeckl, Dorothée Lulé, Jochen Weishaupt (Ulm/DE), Jens Kuhle (Basel/CH), Thomas Meyer (Berlin/DE), Susanne Petri (Hannover/DE), Albert C. Ludolph, Markus Otto (Ulm/DE)

P416 Presymptomatic cerebral perfusion biomarker changes in genetic frontotemporal dementia: results from the GENetic Frontotemporal dementia Initiative (GENFI) Henk Mutsaerts, Saira Saeed Mirza (Toronto/CA), Jonathan Rohrer, David Thomas, David Cash, Enrico De Vita, Katrina Dick, Sebastien Ourselin (London/GB), John van Swieten (Rotterdam/NL), Daniela Galimberti (Milan/IT), James B. Rowe (Cambridge/GB), Caroline Graff (Stockholm/SE), Fabrizio Tagliavini (Milan/IT), Robert Laforce Jr (Quebec/CA), Elizabeth Finger (London/CA), Alexandre Mendonça (Lisbon/PT), Jo Knight (Lancaster/GB), Bradley MacIntosh, Mario Masellis (Toronto/CA)

P417 Decreased Global Field Synchronization (GFS) is an EEG classifier of frontotemporal dementia Vesna Jelic (Stockhom/SE), Per Östberg (Stockholm/SE), Lars-Olof Wahlund (Stockhom/SE), Thomas Koenig (Bern/CH)

P418 Longitudinal Arterial Spin Labeling in the Behavioral Variant of Frontotemporal Lobar Degeneration Faye McKenna, Yann Cobigo, Gabe Marx, Suneth Attygale, Howard Rosen, Bruce Miller (San Francisco, CA/US)

ICFTD 2016 Program September 2, 2016

P419 longstanding Bipolar Affective Disorder and Behavioral Variant Frontotemporal Dementia. Findings in Clinical and Neuroanatomical Phenotypic Patterns. Francy Cruz Sanabria, Rodrigo Pardo Turriago, Diana Matallana Eslava, Pablo Reyes Gavilán (Bogotá/CO)

P420 Cerebral glucose metabolism in C9orf72 mutation carriers Timo Grimmer, Janine Diehl-Schmid, Igor Yakushev (Munich/DE), German FTLD- Consortium (Ulm/DE)

P421 Increased neurofilament light chain correlates with decreased white matter integrity in presymptomatic and symptomatic granulin carriers Jessica L. Panman (Rotterdam, Leiden/NL), Lieke H.H. Meeter (Rotterdam/NL), Elise G.P. Dopper, Lize C. Jiskoot (Rotterdam, Leiden, Amsterdam/NL), Mark J.M.J. Bouts, Christiane Möller (Leiden/NL), Rick van Minkelen (Rotterdam/NL), Raquel Sanchez- Valle, Mircea Balasa (Barcelona/ES), Caroline Graff, Linn Öijerstedt, Vesna Jelic (Huddinge, Stockholm/SE), Luisa Benussi, Roberta Ghidoni, Giuliano Binetti, Borroni Barbara, Alessandro Padovani (Brescia/IT), Daniela Galimberti, Elio Scarpini, Chiara Fenoglio (Milan/IT), Robert Jr Laforce (Québec/CA), Rik Vandenberghe (Leuven/BE), Isabelle Le Ber, Foudil Lamari (Paris/FR), Markus Otto (Ulm/DE), Jonathan D. Rohrer, David M. Cash (London/GB), Serge A.R.B. Rombouts (Leiden/NL), Charlotte E. Teunissen (Amsterdam/NL), Janne M. Papma (Rotterdam/NL), John C. van Swieten (Rotterdam, Amsterdam/NL)

P422 Tau-PET imaging with THK-5351 in patients with clinically diagnosed progressive supranuclear palsy Sonja Schönecker, Matthias Brendel, Joachim Havla, Günter Höglinger, Kai Bötzel, Adrian Danek, Axel Rominger, Johannes Levin (Munich/DE)

P423 Multivariate diagnostic approaches in Frontotemporal lobar degeneration - Data from the german FTLDc Sarah Straub (Ulm/DE), Matthias L. Schroeter (Leipzig/DE), Janine Diehl-Schmid, Adrian Danek (Munich/DE), Christine v. Arnim (Ulm/DE), Lars Bertram (Berlin/DE), Beate Einsiedler (Ulm/DE), Klaus Fassbender (Homburg/Saar/DE), Emily Feneberg (Ulm/DE), Klaus Fliessbach (Bonn/DE), Hans Förstl (Munich/DE), Hans-Jürgen Huppertz (Zurich/CH), Holger Jahn (Hamburg/DE), Frank Jessen (Cologne/DE), Elisabeth Kasper (Rostock/DE), Jan Kassubek, Hans A. Kestler (Ulm/DE), Johannes Kornhuber (Erlangen/DE), Christian Kubisch (Hamburg/DE), Bernhard Landwehrmeyer (Ulm/DE), Martin Lauer (Würzburg/DE), Ludwig Lausser (Ulm/DE), Christina M. Lill (Berlin/DE), Albert Ludolph (Ulm/DE), Manuel Maler (Erlangen/DE), Rainer Muche, Elmar Pinkhardt (Ulm/DE), Johannes Prudlo (Rostock/DE), Lina Riedl (Munich, Rostock/DE), Anja Schneider (Göttingen/DE), Robert Schomburg (Homburg/Saar/DE), Stefan Teipel (Rostock/DE), Ingo Uttner (Ulm/DE), Alexander E. Volk (Hamburg/DE), Markus Otto (Ulm/DE)

P424 Functional connectivity differences between behavioral-variant frontotemporal dementia and early-onset Alzheimer's disease Gabriel Castrillon (Medellin, Munich/CO), Lina Velilla, Margarita Giraldo, Alejandra Zapata, Catalina bustamante, Francisco Lopera (Medellin/CO), Yakeel Quiroz (Medellin, Boston/US)

P425 A mass spectrometry based search for biomarkers in FTD-PGRN Diana Nijholt, Lieke Meeter, Lennard Dekker, Jeroen van Rooij, Theo M. Luider, John van Swieten (Rotterdam/NL)

ICFTD 2016 Program September 2, 2016

11:30–13:30 Postersession III - Mechanisms of cell death Room Ballroom

P426 Cellular changes and toxicity in mouse neuronal cell cultures produced by the cerebrospinal fluid from motor neuron disease patients. Alida Spalloni, Michele Nutini (Roma/IT), Antonella Alberici, Barbara Borroni, Alessandro Padovani (Brescia/IT), Patrizia Longone (Roma/IT)

P427 Simulation of Pathogenic Protein Spread in an Artificial Neural Network Konstantinos Georgiadis, Selina Wray, S_x0013_ebastien Ourselin, Jason D. Warren, Marc Modat (London/GB)

P428 Regulation of synaptic growth by Rab8, IK2/TBK1 and AKT, modifiers of Frontotemporal Dementia Sean Sweeney, Ryan West (York/GB)

P429 The C9ORF72 repeat expansion induces apoptosis by the DNA damage response (DDR) Julie Atkin (Sydney/AU)

P430 Prion-like properties of fragmented α-synuclein fibrils Airi Tarutani, Genjiro Suzuki, Aki Shimozawa, Takashi Nonaka, Shin-ichi Hisanaga, Masato Hasegawa (Tokyo/JP)

P431 Loss-of progranulin leads to early cell type-specific changes in lysosomes of Progranulin knockout mice Julia Götzl, Alessio-Vittorio Colombo, Fargol Mazaheri (Munich/DE), Scott Smith (Boston/US), Katrin Fellerer (Munich/DE), Oleg Butovsky (Boston/US), Sabina Tahirovic, Anja Capell, Christian Haass (Munich/DE)

P432 Role of Trem2 in Neurodegeneration: A systems biology approach Fargol Mazaheri, Gernot Kleinberger, Anna Daria, Georg Werner, Sabina Tahirovic, Dietrich Trümbach, Sebastian Bultmann (Munich/DE), Oleg Butovsky (Munich/US), Christian Haass (Munich/DE)

P433 Disease model for GRN-linked FTLD using patient- and engineered stem cells. Joke Terryn, Philip Van Damme, Catherine Verfaillie (Leuven/BE)

P434 Characterization of the expression and effects of C9ORF72 in cell-based models and human brain Stina Leskelä, Ville Juutilainen, Mari Takalo, Mikael Marttinen, Hilkka Soininen, Mikko Hiltunen, Anne Remes, Annakaisa Haapasalo (Kuopio/FI)

P435 Expression and function of frontotemporal dementia gene C9ORF72 in neuronal cells Stina Leskelä, Mari Takalo, Hilkka Soininen, Anne Remes, Mikko Hiltunen, Annakaisa Haapasalo (Kuopio/FI)

P436 Modeling frontotemporal lobar degeneration using patient-specific iPSCs and iPSC- derived cortical neurons Julia Japtok, Arun Pal, Benedikt Kretner, Vitaly Zimyanin, Xenia Lojewski, Marcel Naumann, Jared Sterneckert (Dresden/DE), Tobias M. Boeckers (Ulm/DE), Alexander Storch (Rostock/DE), Andreas Hermann (Dresden/DE)

P437 Using induced pluripotent stem cells to model C9orf72-linked Frontotemporal Dementia

ICFTD 2016 Program September 2, 2016

Elisavet Preza (London/GB), Ming Zhang, Ekaterina Rogaeva (Toronto/CA), Adrian Isaacs, Martin Rossor, John Hardy, Selina Wray (London/GB)

P438 The “stressed” autophagy: Environmental stress triggers Tau aggregation pathology through an m-TOR-dependent blockage of autophagic clearance Ioannis Sotiropoulos, Joana Silva, Maria Bélem Marques (Braga, Braga/Guimarães/PT), Akihiko Takashima (Obu/JP), Paula Ludovico, Nuno Sousa (Braga, Braga/Guimarães/PT)

P439 Impaired TDP-43 Repression of Nonconserved Cryptic Exons in Alzheimer’s Disease Liam Chen (Baltimore/US)

P440 Modelling dipeptide pathology in C9orf72-linked frontotemporal dementia Sarah Ryan, Janis Bennion Callister, Joan Sim, Sara Rollinson, Stuart Pickering- Brown (Manchester/GB)

P441 Developmental regulation of tau splicing and phosphorylation is conserved in iPSC- neurons and disrupted by the 10+16 intronic mutation in MAPT Teresa Sposito, Elisavet Preza, Argyro Alatza, Colin Mahoney (London/GB), Trevor Bushell, Michele Zagnoni (Glasgow/GB), Tilo Kunath (Edinburgh/GB), Nick Fox, Martin Rossor, John Hardy, Selina Wray (London/GB)

P442 CAGE expression profiling of the human iPS-derived neurons carrying mutations in the C9orf72. Ashutosh Dhingra, Elwira Pyz, Javier Simon-Sanchez, Melissa Castillo-Lizardo, Yvonne Theurer, Ludger Schöls (Tuebingen/DE), Dagmar Timmann-Braun (Essen/DE), Johannes Prudlo (Rostock/DE), Matthis Synofzik, Patrizia Rizzu, Peter Heutink (Tuebingen/DE)

P443 TDP-43 aggregation reflects its loss of function at the proteome level Sonja Prpar Mihevc (Ljubljana/SI), Emanuele Buratti, Marco Baralle, Francisco Ernesto Baralle (Trieste/IT), Boris Rogelj (Ljubljana/SI)

P444 C9orf72 loss of function in mice produces FTD like behavioral deficits Maria Belen Lopez Herdoiza, Baptiste Wilmet, Stéphanie Godart, Delphine Roussel, Caroline Le Duigou, Magali Frah, Jonas Beal, Delphine Bouteiller, Sebastien Dussaud, Gaelle Bruneteau, Isabelle La Ber, Sophie Nicole, Alexis Brice, Morwena Latouche (Paris/FR)

P445 Intranuclear (GGGGCC)n RNA foci induce formation of paraspeckle-like structures Simona Darovic, Maja Štalekar (Ljubljana/SI), Youn-Bok Lee (London/GB), Jure Pohleven (London/SI), Miha Modic (Munich/DE), Marko Fonovič, Boris Turk (Ljubljana/SI), Micha Drukker (Munich/DE), Christopher Shaw (Munich/GB), Boris Rogelj (Ljubljana/SI)

P446 Early markers of tau pathology in young Tau.P301L mice: synaptic plasticity, cognition and neuronal synchrony Amira Latif-Hernandez, An Schreurs, Tariq Ahmed (Leuven/BE), Disha Shah (Antwerp/BE), Fred Van Leuven (Leuven/BE), Annemie Van der Linden (Antwerp/BE), Rudi D'Hooge, Detlef Balschun (Leuven/BE)

P447 A Biphasic Social Dominance Phenotype in Progranulin-insufficient Mice is Associated With Abnormal Cell Signaling and Neuronal Morphology in the Amygdala and Prefrontal Cortex Andrew Arrant, Anthony Filiano, Brian Warmus, Alicia Hall, Erik Roberson (Birmingham, AL/US)

ICFTD 2016 Program September 2, 2016

P448 Production, detection, and characterization of proganulin (PGRN) and granulins (GRNs). Christopher Holler, Georgia Taylor, Tom Kukar (Atlanta/US)

11:30–13:30 Postersession III - Disease modulation Room Ballroom

P449 Drug screening for progranulin-deficient FTD James Julian Doyle, Claudia Maios, Andrew Bateman, Hugh Bennett, J. Alex Parker (Montreal/CA)

P450 Clinical evidence for disease anticipation in C9orf72 families Sara Van Mossevelde (Antwerp, Edegem/BE), Sebastiaan Engelborghs, Ilse Gijselinck (Antwerp/BE), Jan De Bleecker (Ghent/BE), Julie van der Zee (Antwerp/BE), Anne Sieben (Antwerp, Ghent/BE), Kristel Sleegers (Antwerp/BE), Rik Vandenberghe (Leuven/BE), Tim Van Langenhove, Jonathan Baets (Antwerp, Edegem/BE), Olivier Deryck (Edegem, Bruges/BE), Patrick Santens (Ghent/BE), Adrian Ivanoiu (Brussels/BE), Christiana Willems (Hasselt/BE), Veerle Bäumer, Van den Broeck Marleen, Karin Peeters, Maria Mattheijssens (Antwerp/BE), De Jonghe Peter, Patrick Cras, Jean-Jacques Martin (Antwerp, Edegem/BE), Marc Cruts, Peter P. De Deyn, Christine Van Broeckhoven (Antwerp/BE)

P451 Intracerebroventricular infusion of streptozotocin alters brain neurochemistry: Embelin attenuates streptozotocin-induced neurochemical alterations and cognitive impairment in rats Rahul Deshmukh, Rimpi Arora (Moga/IN)

P452 The role of FTD/ALS assciated protein, TDP-43, in neurite and synapse health and function Rachel Atkinson, Jacqueline Leung, Carmen Fernandez-Martos (Hobart/AU), Julie Atkin (Sydney/AU), James Vickers, Anna King (Hobart/AU)

P453 The Belgian GRN founder family anno 2016: a textbook example of phenotype heterogeneity Eline Wauters, Sara Van Mossevelde, Kristel Sleegers, Ilse Gijselinck, Stéphanie Philtjens, Anne Sieben (Antwerp/BE), Tim Van Langenhove (Antwerp, Edegem/BE), Sebastiaan Engelborghs (Antwerp/BE), Mathieu Vandenbulcke (Leuven/BE), Maria Mattheijssens, Karin Peeters, Ivy Cuijt, Jean-Jacques Martin (Antwerp/BE), Patrick Cras (Antwerp, Edegem/BE), Patrick Santens (Ghent/BE), Rik Vandenberghe (Leuven/BE), Peter P. De Deyn (Antwerp, Groningen, The Netherlands/BE), Julie van der Zee, Marc Cruts, Christine Van Broeckhoven (Antwerp/BE)

P454 Loss-of progranulin leads to a cell-autonomous lysosomal phenotype Georg Werner, Katrin Fellerer, Christina M. Lang, Christian Haass, Anja Capell (Munich/DE)

P455 Nature and nurture in modulating brain damage in pre-symptomatic monogenic FTD: results from the GENFI study. Enrico Premi (Brescia/JM), Jonathan Rohrer (London, UK/GB), Mario Grassi (Pavia, Italy/IT), John van Swieten (Rotterdam, Netherlands/NL), Daniela Galimberti (Milan, Italy/IT), Caroline Graff (Huddinge, Sweden/SE), Mario Masellis (Toronto, Canada/CA), Fabrizio Tagliavini (Milan, Italy/IT), James Rowe (Cambridge, UK/GB), Robert Laforce (Laval, QC, Canada/CA), Elizabeth Finger (London, ON,

ICFTD 2016 Program September 2, 2016

Canada/CA), Giovanni Frisoni (Brescia, Italy/IT), Alexandre de Mendoça (Lisbon, Portugal/PT), Sandro Sorbi (Florence, Italy/IT), Stefano Gazzina, Maura Cosseddu (Brescia/IT), Silvana Archetti, Roberto Gasparotti (Brescia, Italy/IT), Marta Manes, Alessandro Padovani, Barbara Borroni (Brescia/IT)

P456 New onset Autoimmune disease presenting in symptomatic Fronotemporal dementia patients Zachary Miller, Natanya Russek, Robin Ketelle, Anna Karydas, Lea Grinberg, Maria Luisa Gorno-Tempini, Bill Seeley, Bruce Miller (San Francisco/US)

P457 Lifecourse factors and cognitive reserve in FTD: education, bilingualism, and place of dwelling play a role Suvarna Alladi (Bengaluru/IN), Thomas H Bak (Edinburgh/GB), Shailaja Mekala, Divyaraj Gollahalli, Bapiraju Surampudi, Vasanta Duggirala, Jaydip Ray Chaudhuri, Subhash Kaul (Hyderabad/IN)

P458 TDP-43 and FUS are exported from the nucleus independent of Exportin-1/CRM1 Helena Ederle, Dorothee Dormann (Planegg-Martinsried/DE)

P459 Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau pathology in wild-type and MAPT transgenic mice Robert Rottscholl, Marlen Lunow, Britta Jainsch (Marburg/DE), Gesine Respondek, Matthias Höllerhage, Thomas W. Rösler, Hong Xu (Marburg, Munich/DE), Emilie Bony, Jessica Le Ven (Châtenay-Malabry/FR), Vincent Guérineau (Gif-sur- Yvette/FR), Isabelle Schmitz-Afonso (Gif-sur-Yvette, Mont-Saint-Aignan Cedex/FR), Pierre Champy (Châtenay-Malabry/FR), Wolfgang H. Oertel (Marburg/DE), Elizabeth S. Yamada (Marburg, Belém/BR), Günter U. Höglinger (Marburg, Munich/DE)

11:30–13:30 Treatment (pharmacological/ non-pharmacological) Room Ballroom

P460 TREM2-deficiency reduces the efficacy of immunotherapeutic amyloid clearance Xianyuan Xiang, Georg Werner (Munich/DE), Bernd Bohrmann (Basel/CH), Fargol Mazaheri, Anja Capell, Regina Feederle (Munich/DE), Irene Knuesel (Basel/DE), Gernot Kleinberger, Christian Haass (Munich/DE)

P461 Low-dose Lithium treatment for agitation in Frontotemporal dementia: A case series D.P. Devanand, Gregory Pelton, Kristina D'Antonio, Jesse Strickler, William Kreisl, James Noble, Karen Marder, Anne Skomorowsky, Edward Huey (New York, NY/US)

P462 Communication Bridge: An internet-based person centered intervention for improving access to care and quality of life for individuals with dementia Emily Rogalski, Marie Saxon, Marya Corden, M.-Marsel Mesulam, Kathryn Borio, Becky Khayum (Chicago/US)

P463 Improving speech production in progressive non-fluent aphasia: a study protocol Carlo Wilke, Marc Himmelbach, Matthis Synofzik (Tuebingen/DE)

P464 INTERACTIVE SYSTEM DESIGN TO MAINTAIN FUNCTIONALITY IN FTLD PATIENTS. Angela Martínez (Bogotá, Lyon/CO), Daniela Patino-Hernandez, Elkin García- Cifuentes, Silvia Suarez, Andrea Patiño, Carlos A. Cano-Gutiérrez, Omar Ramírez Perez, Diego A. Chavarro-Carvajal (Bogotá/CO)

ICFTD 2016 Program September 2, 2016

P465 Neuroprotective effects of Cerebrolysin in triple repeat (3R) tau transgenic model of Pick’s disease and fronto-temporal tauopathies Edward Rockenstein, Kirenjeet Ubhi, Michael Mante, Jazmin Florio, Anthony Adame (La Jolla/US), Stefan Winter, Dieter Meier (Unterach/AT), Eliezer Masliah (La Jolla/US), Hemma Brandstaetter (Unterach/AT)

P466 Disease Modifing Treatment for a bvFTD case. Mikel Tainta, Myriam Barandiarán, Alazne Gabilondo, Fermin Moreno, Begoña Indakoetxea, Adolfo López de Munain (San Sebastian/ES)

P468 Non-invasive salience network modulation in behavioral variant frontotemporal dementia: preliminary results from a case series Lorenzo Pini (Brescia/IT), Ilaria Boscolo Galazzo (Verona, London/IT), Chiara Cobelli, Clarissa Ferrari, Maria Cotelli (Brescia/IT), Giovanni Battista Frisoni (Brescia, Geneva/IT), Rosa Manenti (Brescia/IT), Francesca Benedetta Pizzini (Verona/IT), Michela Pievani (Brescia/IT)

P469 Identification of best-practice-strategies in caring for people with behavioral variant frontotemporal dementia (bvFTD): Exploration of clinical expertise - Study protocol Claudia Dinand (Witten/DE), Martin Berwig (Witten, Leipzig/DE), Margareta Halek (Witten/DE)

P470 Efficacy of a group visual art therapy with frontotemporal dementia patients: a pilot study Silvia Fostinelli, Guido Uggeri, Michela Facchinetti, Luisa Benussi, Roberta Ghidoni, Giuseppina Di Giovanni, Giuseppe Rossi, Elena Bertocchi, Rosaria Pioli, Giuliano Binetti (Brescia/IT)

P471 Application of MarteMeo® Counselling to people with behavior variant frontotemporal dementia and their caregivers (AMEO-FTD) – Study protocol for a feasibility study Martin Berwig (Witten, Leipzig/DE), Claudia Dinand, Margareta Halek (Witten/DE)

P472 Effect of repetitive transcranial magnetic stimulation on cognitive, behavioral and emotional functioning in behavioral variant of frontotemporal dementia Katarzyna Kowalska, Jakub Antczak, Marta Banach, Aleksandra Klimkowicz - Mrowiec (Kraków/PL)

P473 Advanced frontotemporal dementia - an indication for palliative care? Lina Riedl, Janine Diehl-Schmid (Munich/DE)

P474 Improvement of speed processing and neuropsychiatric symptoms in Fronto- Temporal Dementia after transcranial Direct Current Stimulation Simona Gardini (Parma/IT), Roberta Ferrucci, Fabiana Ruggiero, Maurizio Vergari, Francesca Mameli (Milan/IT), Marco Spallazzi, Federica Barocco, Anna Miucci (Parma/IT), Andrea Arighi (Milan/IT), Paolo Caffarra (Parma, Parma, italy/IT), Elio Scarpini, Alberto Priori (Milan/IT)

P475 Targeting tau protein in therapy of human tauopathies: Can we use the same vaccine for treatment of various tau neurodegenerative diseases? Norbert Zilka, Branislav Kovacech, Eva Kontsekova, Michal Novak (Bratislava/SK)

P476 Frontotemporal dementia (FTD): A review and a general approach to non- pharmacological treatment – the Hong Kong experience Connie Tin Yee YAN, Joshua TSOH, Daphne ST LAW (Hong Kong/HK)

ICFTD 2016 Program September 2, 2016

P477 Study design of a phase 2 randomized controlled trial of intranasal oxytocin for symptomatic treatment in FTD Elizabeth Finger (London/CA), Harold Feldman (San Diego, Vancouver/US), Jeffrey Cummings (Las Vegas/US), Adam Boxer (San Francisco/US)

P478 Clinical drug trials in behavioral variant frontotemporal dementia: problems and challenges Janine Diehl-Schmid (Munich/DE)

13:30–14:50 Session 10: Disease modulation Room Lecture Hall Chairs Christian Haass (Munich/DE), Don Cleveland (San Diego, CA/US)

13:30 Gene silencing therapy for human neurodegenerative disease Don Cleveland (San Diego, CA/US)

13:55 Therapeutic reduction of ataxin 2 improves motor performance and extends lifespan in a mouse model of TDP-43 proteinopathy Aaron Gitler (Stanford, CA/US)

14:20 hnRNP proteins as general enhancers or suppressors of TDP-43 gain- and loss-of- function pathological properties O18 Emanuele Buratti, Chiara Appocher, Sara Cappelli, Cristiana Stuani, Maurizio Romano, Fatemeh Mohagheghi, Fabian Feiguin (Trieste/IT)

14:35 Reducing levels of Tmem106b as a therapeutic strategy in an FTLD-TDP mouse model O19 Alexandra Nicholson, Ralph Perkerson, Jeannie Chew, Aishe Kurti, Tammee Parsons, Emilie Perkerson, Karen Jansen-West, Monica Castanedes-Casey, Linda Rousseau, Jeannette Stankowski, Dennis Dickson, John Fryer, Leonard Petrucelli, Rosa Rademakers (Jacksonville/US)

15:10–16:40 Session 11: Treatment Room Lecture Hall Chairs Adam Boxer (San Francisco, CA/US), Jonathan Rohrer (London/GB)

15:20 A phase 3 trial of the tau and TDP-43 aggregation inhibitor, leuco-methylthioninium- bis(hydromethanesulfonate) (LMTM), for behavioural variant frontotemporal dementia (bvFTD) O20 Howard Feldman (La Jolla/US), Serge Gauthier (Quebec/CA), Lon Schneider (Los Angeles/US), Gordon Wilcock (Oxford/GB), Giovanni Frisoni (Geneva/CH), Peter Bentham (Birmingham/GB), Jiri Hardlund (Aberdeen/GB), Karin Kook (Bethesda/US), Damon Wischik, Bjoern Schelter, John Storey, Charles Harrington, Claude Wischik (Aberdeen/GB)

15:35 An 8-week, Open-label, Dose-Finding Study of Nimodipine for the Treatment of Progranulin Insufficiency from GRN Gene Mutations O21 Sharon Sha (Palo Alto/US), Zachary Miller, Sang-Won Min, Yungui Zhou, Laura Mitic, Anna Karydas, Mary Koestler, Richard Tsai, Chiara Corbetta-Rastelli, Sophie Lin, Emma Hare, Jesse Brown, Ryan Fitch, Ryan Powers, Lauren Herl Martens (San Francisco/US), Mehrdad Shamloo (Palo Alto/US), Anne Fagan (St. Louis/US), Robert Farese, Jr., William Seeley, Rodney Pearlman, Bruce Miller, Li Gan, Adam Boxer (San Francisco/US)

ICFTD 2016 Program September 2, 2016

15:50 Clinical trial of COMT-inhibition in 28 patients with FTD O22 Edward Huey (New York, NY/US), Venkata Mattay (Baltimore, MD/US), Christopher Habeck, Masood Manoocheheri (New York, NY/US), Nicole Armstrong (Baltimore, MD/US), D.P. Devanand (New York, NY/US), Daniel Weinberger (Baltimore, MD/US), Jordan Grafman (Chicago, IL/US)

16:05 Panel discussion: Update and future directions on clinical trials in FTD and associated disorders Adam Boxer (San Francisco, CA/US), Jonathan Rohrer (London/GB)

16:40–17:00 Closing Remarks Room Lecture Hall Chairs Janine Diehl-Schmid (Munich/DE), Manuela Neumann (Tuebingen/DE)