EID Vol15no4 Cover Copy

Total Page:16

File Type:pdf, Size:1020Kb

EID Vol15no4 Cover Copy Peer-Reviewed Journal Tracking and Analyzing Disease Trends pages 519–688 EDITOR-IN-CHIEF D. Peter Drotman Managing Senior Editor EDITORIAL BOARD Polyxeni Potter, Atlanta, Georgia, USA Dennis Alexander, Addlestone Surrey, United Kingdom Senior Associate Editor Barry J. Beaty, Ft. Collins, Colorado, USA Brian W.J. Mahy, Atlanta, Georgia, USA Martin J. Blaser, New York, New York, USA Christopher Braden, Atlanta, GA, USA Associate Editors Carolyn Bridges, Atlanta, GA, USA Paul Arguin, Atlanta, Georgia, USA Arturo Casadevall, New York, New York, USA Charles Ben Beard, Ft. Collins, Colorado, USA Kenneth C. Castro, Atlanta, Georgia, USA David Bell, Atlanta, Georgia, USA Thomas Cleary, Houston, Texas, USA Charles H. Calisher, Ft. Collins, Colorado, USA Anne DeGroot, Providence, Rhode Island, USA Michel Drancourt, Marseille, France Vincent Deubel, Shanghai, China Paul V. Effl er, Perth, Australia Ed Eitzen, Washington, DC, USA K. Mills McNeill, Kampala, Uganda David Freedman, Birmingham, AL, USA Nina Marano, Atlanta, Georgia, USA Kathleen Gensheimer, Augusta, ME, USA Martin I. Meltzer, Atlanta, Georgia, USA Peter Gerner-Smidt, Atlanta, GA, USA David Morens, Bethesda, Maryland, USA Duane J. Gubler, Singapore J. Glenn Morris, Gainesville, Florida, USA Richard L. Guerrant, Charlottesville, Virginia, USA Patrice Nordmann, Paris, France Scott Halstead, Arlington, Virginia, USA Tanja Popovic, Atlanta, Georgia, USA David L. Heymann, Geneva, Switzerland Jocelyn A. Rankin, Atlanta, Georgia, USA Daniel B. Jernigan, Atlanta, Georgia, USA Didier Raoult, Marseille, France Charles King, Cleveland, Ohio, USA Pierre Rollin, Atlanta, Georgia, USA Keith Klugman, Atlanta, Georgia, USA Dixie E. Snider, Atlanta, Georgia, USA Takeshi Kurata, Tokyo, Japan Frank Sorvillo, Los Angeles, California, USA S.K. Lam, Kuala Lumpur, Malaysia David Walker, Galveston, Texas, USA Bruce R. Levin, Atlanta, Georgia, USA David Warnock, Atlanta, Georgia, USA Myron Levine, Baltimore, Maryland, USA J. Todd Weber, Atlanta, Georgia, USA Stuart Levy, Boston, Massachusetts, USA Henrik C. Wegener, Copenhagen, Denmark John S. MacKenzie, Perth, Australia Founding Editor Marian McDonald, Atlanta, Georgia, USA Joseph E. McDade, Rome, Georgia, USA John E. McGowan, Jr., Atlanta, Georgia, USA Tom Marrie, Edmonton, Alberta, Canada Copy Editors Ban Mishu-Allos, Nashville, Tennessee, USA Karen Foster, Thomas Gryczan, Beverly Merritt, Rhonda Ray, Philip P. Mortimer, London, United Kingdom Carol Snarey, P. Lynne Stockton Fred A. Murphy, Galveston, Texas, USA Production Barbara E. Murray, Houston, Texas, USA Carrie Huntington, Ann Jordan, Carole Liston, Shannon O’Connor, P. Keith Murray, Geelong, Australia Reginald Tucker Stephen M. Ostroff, Harrisburg, Pennsylvania, USA David H. Persing, Seattle, Washington, USA Editorial Assistant Richard Platt, Boston, Massachusetts, USA Susanne Justice Gabriel Rabinovich, Buenos Aires, Argentina www.cdc.gov/eid Mario Raviglione, Geneva, Switzerland Leslie Real, Atlanta, Georgia, USA Emerging Infectious Diseases David Relman, Palo Alto, California, USA Emerging Infectious Diseases is published monthly by the Centers for Disease Connie Schmaljohn, Frederick, Maryland, USA Control and Prevention, 1600 Clifton Road, Mailstop D61, Atlanta, GA 30333, USA. Telephone 404-639-1960, fax 404-639-1954, email [email protected]. Tom Schwan, Hamilton, Montana, USA Ira Schwartz, Valhalla, New York, USA The opinions expressed by authors contributing to this journal do not necessar- Tom Shinnick, Atlanta, Georgia, USA ily refl ect the opinions of the Centers for Disease Control and Prevention or the Bonnie Smoak, Bethesda, Maryland, USA institutions with which the authors are affi liated. Rosemary Soave, New York, New York, USA All material published in Emerging Infectious Diseases is in the public domain P. Frederick Sparling, Chapel Hill, North Carolina, USA and may be used and reprinted without special permission; proper citation, how- Robert Swanepoel, Johannesburg, South Africa ever, is required. Phillip Tarr, St. Louis, Missouri, USA Use of trade names is for identifi cation only and does not imply endorsement Timothy Tucker, Cape Town, South Africa by the Public Health Service or by the U.S. Department of Health and Human Elaine Tuomanen, Memphis, Tennessee, USA Services. John Ward, Atlanta, Georgia, USA ∞ Emerging Infectious Diseases is printed on acid-free paper that meets the requirements of Mary E. Wilson, Cambridge, Massachusetts, USA ANSI/NISO 239.48-1992 (Permanence of Paper) Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 15, No. 4, April 2009 April 2009 Oseltamivir-Resistant Infl uenza Virus A (H1N1), Europe, 2007–08 Season ....................... 552 A. Meijer et al. A high level of virus circulation and introduction of an antigenic drift variant in a susceptible population contributed to the spread of resistant virus. Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil ........................................... 561 On the Cover L.T.M. Figueiredo et al. Ray Troll (b. 1954) This syndrome is an increasing health problem because of Fishes of Amazonia (2000) human encroachment into habitats of rodent reservoirs. Acrylic on canvas (21.13 m × 4.57 m) Miami Museum of Science, Miami, Florida, USA Dispatches About the Cover p. 682 568 Rift Valley Fever, Mayotte, 2007–2008 D. Sissoko et al. Research 571 High Prevalence of Spirochetosis in Cholera Patients, Bangladesh Experimental Infection of Potential E.J. Nelson et al. Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico ............................... 519 574 Genetic Diversity of Toscana Virus E.R. Deardorff et al. p. 544 X. Collao et al. Multiple wild rodents can serve as amplifying reservoir hosts 578 Co-infection with Pansensitive for virus subtype IE. and Multidrug-Resistant Strains of Mycobacterium tuberculosis Exotic Small Mammals as Potential M.P. Mendez et al. Reservoirs of Zoonotic Bartonella spp. .......... 526 581 Enterovirus 71 Maternal Antibodies in K. Inoue et al. Infants, Taiwan By serving as reservoirs, these mammals may increase risk S.-T. Luo et al. for human infections. 585 Correlation between Tick Density and Enhancing Time Series Detection p. 589 Pathogen Endemicity, New Hampshire Algorithms for Automated Biosurveillance .... 533 S.T. Walk et al. J.I. Tokars et al. 588 Lobomycosis in Offshore Bottlenose Algorithm modifi cations may improve sensitivity for detecting Dolphins (Tursiops truncatus), North artifi cially added data. Carolina D.S. Rotstein et al. Animal Reservoir Hosts and Fish-borne Zoonotic Trematode 591 Concurrent Chikungunya and Dengue Infections on Fish Farms, Vietnam .................. 540 Virus Infections, Gabon, 2007 E.M. Leroy et al. N.T.L. Anh et al. Cats, dogs, and pigs may be reservoir hosts. 594 Gnathostomiasis Acquired by British Tourists in Botswana Novel Type of Streptococcus J.S. Herman et al. pneumoniae Causing Multidrug- 598 Skin and Soft Tissue Infections Resistant Acute Otitis Media (Patera Foot) in Immigrants, Spain in Children ..........................................................547 H.-G. Ternavasio-de la Vega et al. Q. Xu et al. A new multidrug-resistant strain of serotype 19A has been 601 Congenital Transmission of Chagas characterized in upstate New York. Disease in Latin American Immigrants in Switzerland Y. Jackson et al. Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 15, No. 4, April 2009 604 Genotype V St. Louis Encephalitis Virus, Florida C.L. Ottendorfer et al. April 2009 Human Febrile Illness Caused Another Dimension by Encephalomyocarditis Virus 681 Travels in Gene Space Infection, Peru .................................................... 640 J.W. Tang M.S. Oberste et al. This virus was identifi ed in serum samples from 2 febrile patients. Letters 607 Chagasic Cardiomyopathy in Immigrants Dispatches from Latin America to Spain 647 Rapid Diagnostic Test for Syphilis in 608 Lethal Bluetongue Virus Serotype 1 High-Risk Populations, Manaus, Brazil Infection in Llamas M. Sabidó et al. 610 Spotted Fever Group Rickettsia Closely 650 Spatial Distribution of Leprosy in the Related to R. japonica, Thailand Amazon Region of Brazil M.L.F. Penna et al. 611 Segniliparus rugosus Infection, Australia 653 Oral Transmssion of Chagas Disease by 613 Multigenotype Q Fever Outbreak, the Consumption of Açaí Palm Fruit, Brazil Netherlands p. 635 A.A. Nóbrega et al. 614 Buruli Ulcer and Vector-Borne Diseases, 656 Severe Acquired Toxoplasmosis Caused Victoria, Australia by Toxoplasma gondii, French Guiana 616 Avian Infl uenza Risk Perception among B. Carme et al. Poultry Workers, Nigeria 659 Links between Climate, Malaria, and 617 Mycobacterium avium subsp. Wetlands in the Amazon Basin hominissuis Infection in a Pet Parrot S.H. Olsen et al. 619 Mycobacterium colombiense and 663 Seroprevalence of Kaposi Sarcoma– Pseudotuberculous Lymphadenopathy associated Herpesvirus, Brazilian 621 Leptospira noguchii and Human and Amazon Animal Leptospirosis, Southern Brazil M.C. Nascimento et al. 623 Aquaculture and Florfenicol Resistance in 668 Dengue and Malaria in Cayenne Hospital, Salmonella enterica Serovar Typhimurium French Guiana DT104 (response) B. Carme et al. The Amazon Region Letters 672 Lobomycosis in Inshore and Estuarine Commentary p. 647 Dolphins The Status of Infectious Disease 673 Variations in Leprosy Manifestations in the Amazon Region ....................................... 625 among HIV-Positive Patients, Manaus, P.L. Tauil Brazil 675 Suspected Brazilian Purpuric Fever, Synopsis Brazilian Amazon Region High Incidence
Recommended publications
  • Whole Genome Analysis of Leptospira Licerasiae Provides Insight Into Leptospiral Evolution and Pathogenicity
    Whole Genome Analysis of Leptospira licerasiae Provides Insight into Leptospiral Evolution and Pathogenicity Jessica N. Ricaldi1,2., Derrick E. Fouts3., Jeremy D. Selengut3, Derek M. Harkins3, Kailash P. Patra2, Angelo Moreno2, Jason S. Lehmann2, Janaki Purushe3, Ravi Sanka3, Michael Torres4, Nicholas J. Webster5, Joseph M. Vinetz1,2,4*, Michael A. Matthias2* 1 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, 2 Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America, 3 J. Craig Venter Institute, Rockville, Maryland, United States of America, 4 Departamento de Ciencias Celulares y Moleculares, Laboratorio de Investigacio´n y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru, 5 Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America Abstract The whole genome analysis of two strains of the first intermediately pathogenic leptospiral species to be sequenced (Leptospira licerasiae strains VAR010 and MMD0835) provides insight into their pathogenic potential and deepens our understanding of leptospiral evolution. Comparative analysis of eight leptospiral genomes shows the existence of a core leptospiral genome comprising 1547 genes and 452 conserved genes restricted to infectious species (including L. licerasiae) that are likely to be pathogenicity-related. Comparisons of the functional content of the genomes suggests that L. licerasiae retains several proteins related to nitrogen, amino acid and carbohydrate metabolism which might help to explain why these Leptospira grow well in artificial media compared with pathogenic species. L. licerasiae strains VAR010T and MMD0835 possess two prophage elements.
    [Show full text]
  • Abstract Pultorak, Elizabeth Lauren
    ABSTRACT PULTORAK, ELIZABETH LAUREN. The Epidemiology of Lyme Disease and Bartonellosis in Humans and Animals. (Under the direction of Edward B. Breitschwerdt). The expansion of vector borne diseases in humans, a variety of mammalian hosts, and arthropod vectors draws attention to the need for enhanced diagnostic techniques for documenting infection in hosts, effective vector control, and treatment of individuals with associated diseases. Through improved diagnosis of vector-borne disease in both humans and animals, epidemiological studies to elucidate clinical associations or spatio-temporal relationships can be assessed. Veterinarians, through the use of the C6 peptide in the SNAP DX test kit, may be able to evaluate the changing epidemiology of borreliosis through their canine population. We developed a survey to evaluate the practices and perceptions of veterinarians in North Carolina regarding borreliosis in dogs across different geographic regions of the state. We found that veterinarians’ perception of the risk of borreliosis in North Carolina was consistent with recent scientific reports pertaining to geographic expansion of borreliosis in the state. Veterinarians should promote routine screening of dogs for Borrelia burgdorferi exposure as a simple, inexpensive form of surveillance in this transitional geographic region. We next conducted two separate studies to evaluate Bartonella spp. bacteremia or presence of antibodies against B. henselae, B. koehlerae, or B. vinsonii subsp. berkhoffii in 296 patients examined by a rheumatologist and 192 patients with animal exposure (100%) and recent animal bites and scratches (88.0%). Among 296 patients examined by a rheumatologist, prevalence of antibodies (185 [62%]) and Bartonella spp. bacteremia (122 [41.1%]) was high.
    [Show full text]
  • Comparative Genomic Analysis of the Genus Leptospira
    What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. Derrick E Fouts, Michael A Matthias, Haritha Adhikarla, Ben Adler, Luciane Amorim-Santos, Douglas E Berg, Dieter Bulach, Alejandro Buschiazzo, Yung-Fu Chang, Renee L Galloway, et al. To cite this version: Derrick E Fouts, Michael A Matthias, Haritha Adhikarla, Ben Adler, Luciane Amorim-Santos, et al.. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Lep- tospira.. PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (2), pp.e0004403. 10.1371/journal.pntd.0004403. pasteur-01436457 HAL Id: pasteur-01436457 https://hal-pasteur.archives-ouvertes.fr/pasteur-01436457 Submitted on 16 Apr 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons CC0 - Public Domain Dedication| 4.0 International License RESEARCH ARTICLE What Makes a Bacterial Species Pathogenic?: Comparative Genomic Analysis of the Genus Leptospira Derrick E. Fouts1*, Michael A. Matthias2, Haritha Adhikarla3, Ben Adler4, Luciane Amorim- Santos3,5, Douglas E. Berg2, Dieter Bulach6, Alejandro Buschiazzo7,8, Yung-Fu Chang9, Renee L. Galloway10, David A. Haake11,12, Daniel H. Haft1¤, Rudy Hartskeerl13, Albert I.
    [Show full text]
  • Spirochete Flagella and Motility
    biomolecules Review Spirochete Flagella and Motility Shuichi Nakamura Department of Applied Physics, Graduate School of Engineering, Tohoku University, 6-6-05 Aoba, Aoba-ku, Sendai, Miyagi 980-8579, Japan; [email protected]; Tel.: +81-22-795-5849 Received: 11 March 2020; Accepted: 3 April 2020; Published: 4 April 2020 Abstract: Spirochetes can be distinguished from other flagellated bacteria by their long, thin, spiral (or wavy) cell bodies and endoflagella that reside within the periplasmic space, designated as periplasmic flagella (PFs). Some members of the spirochetes are pathogenic, including the causative agents of syphilis, Lyme disease, swine dysentery, and leptospirosis. Furthermore, their unique morphologies have attracted attention of structural biologists; however, the underlying physics of viscoelasticity-dependent spirochetal motility is a longstanding mystery. Elucidating the molecular basis of spirochetal invasion and interaction with hosts, resulting in the appearance of symptoms or the generation of asymptomatic reservoirs, will lead to a deeper understanding of host–pathogen relationships and the development of antimicrobials. Moreover, the mechanism of propulsion in fluids or on surfaces by the rotation of PFs within the narrow periplasmic space could be a designing base for an autonomously driving micro-robot with high efficiency. This review describes diverse morphology and motility observed among the spirochetes and further summarizes the current knowledge on their mechanisms and relations to pathogenicity, mainly from the standpoint of experimental biophysics. Keywords: spirochetes; periplasmic flagella; motility; chemotaxis; molecular motor 1. Introduction Motility systems of living organisms are currently classified into 18 types [1]. Even when focusing on bacteria only, the motility is diverse when bacterial species are concerned [2].
    [Show full text]
  • Isolates from Colonic Spirochaetosis in Humans Show High Genomic
    bioRxiv preprint doi: https://doi.org/10.1101/544502; this version posted February 8, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Isolates from colonic spirochaetosis in humans show high genomic divergence and carry 2 potential pathogenic features but are not detected by 16S amplicon sequencing using 3 standard primers for the human microbiota 4 5 Kaisa Thorell a, b, Linn Inganäs a, c, Annette Backhans d, Lars Agréus c, Åke Öst e, Marjorie 6 Walker f, Nicholas J Talley f, Lars Kjellström g, Anna Andreasson c, h, Lars Engstrand a, i 7 8 a Center for Translational Microbiome Research, Department of Microbiology, Cell and 9 Tumor biology, Karolinska Institutet, Stockholm, Sweden 10 b Department for Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, 11 Gothenburg, Sweden 12 c Division for Family Medicine and General Practice, Department for Neurobiology, Care 13 Sciences and Society, Karolinska Institutet, Huddinge, Sweden 14 d Department of Clinical Sciences, Swedish University of Agriculture, Uppsala, Sweden 15 e Pathology, Aleris Medilab, Taby, Sweden. 16 f University of Newcastle, New South Wales, Australia 17 g Gastromottagningen City, Stockholm, Sweden 18 h Stress Research Institute, Stockholm University, Stockholm, Sweden 19 i Clinical Genomics, Science for Life Laboratory, Stockholm, Sweden 20 Corresponding authors: [email protected], [email protected] 21 bioRxiv preprint doi: https://doi.org/10.1101/544502; this version posted February 8, 2019.
    [Show full text]
  • What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
    UC San Diego UC San Diego Previously Published Works Title What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. Permalink https://escholarship.org/uc/item/0g08233z Journal PLoS neglected tropical diseases, 10(2) ISSN 1935-2727 Authors Fouts, Derrick E Matthias, Michael A Adhikarla, Haritha et al. Publication Date 2016-02-18 DOI 10.1371/journal.pntd.0004403 Peer reviewed eScholarship.org Powered by the California Digital Library University of California RESEARCH ARTICLE What Makes a Bacterial Species Pathogenic?: Comparative Genomic Analysis of the Genus Leptospira Derrick E. Fouts1*, Michael A. Matthias2, Haritha Adhikarla3, Ben Adler4, Luciane Amorim- Santos3,5, Douglas E. Berg2, Dieter Bulach6, Alejandro Buschiazzo7,8, Yung-Fu Chang9, Renee L. Galloway10, David A. Haake11,12, Daniel H. Haft1¤, Rudy Hartskeerl13, Albert I. Ko3,5, Paul N. Levett14, James Matsunaga11,12, Ariel E. Mechaly7, Jonathan M. Monk15, Ana L. T. Nascimento16,17, Karen E. Nelson1, Bernhard Palsson15, Sharon J. Peacock18, Mathieu Picardeau19, Jessica N. Ricaldi20, Janjira Thaipandungpanit21, Elsio A. Wunder, Jr.3,5, X. Frank Yang22, Jun-Jie Zhang22, Joseph M. Vinetz2,20,23* 1 J. Craig Venter Institute, Rockville, Maryland, United States of America, 2 Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America, 3 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States
    [Show full text]
  • Brachyspira Murdochii Type Strain (56-150)
    Lawrence Berkeley National Laboratory Recent Work Title Complete genome sequence of Brachyspira murdochii type strain (56-150). Permalink https://escholarship.org/uc/item/2x39941n Journal Standards in genomic sciences, 2(3) ISSN 1944-3277 Authors Pati, Amrita Sikorski, Johannes Gronow, Sabine et al. Publication Date 2010-06-15 DOI 10.4056/sigs.831993 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Standards in Genomic Sciences (2010) 2:260-269 DOI:10.4056/sigs.831993 Complete genome sequence of Brachyspira murdochii type strain (56-150T) Amrita Pati1, Johannes Sikorski2, Sabine Gronow2, Christine Munk3, Alla Lapidus1, Alex Copeland1, Tijana Glavina Del Tio1, Matt Nolan1, Susan Lucas1, Feng Chen1, Hope Tice1, Jan-Fang Cheng1, Cliff Han1,3, John C. Detter1,3, David Bruce1,3, Roxanne Tapia3, Lynne Goodwin1,3, Sam Pitluck1, Konstantinos Liolios1, Natalia Ivanova1, Konstantinos Mavromatis1, Natalia Mikhailova1, Amy Chen4, Krishna Palaniappan4, Miriam Land1,5, Loren Hauser1,5, Yun-Juan Chang1,5, Cynthia D. Jeffries1,5, Stefan Spring2, Manfred Rohde6, Markus Göker2, James Bristow1, Jonathan A. Eisen1,7, Victor Markowitz4, Philip Hugenholtz1, Nikos C. Kyrpides1, and Hans-Peter Klenk2* 1 DOE Joint Genome Institute, Walnut Creek, California, USA 2 DSMZ – German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany 3 Los Alamos National Laboratory, Bioscience Division, Los Alamos, New Mexico, USA 4 Biological Data Management and Technology Center, Lawrence Berkeley National Laboratory, Berkeley, California, USA 5 Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA 6 HZI – Helmholtz Centre for Infection Research, Braunschweig, Germany 7 University of California Davis Genome Center, Davis, California, USA *Corresponding author: Hans-Peter Klenk Keywords: host-associated, non-pathogenic, motile, anaerobic, Gram-negative, Brachyspira- ceae, Spirochaetes, GEBA Brachyspira murdochii Stanton et al.
    [Show full text]
  • Ru 2015 150 263 a (51) Мпк A61k 31/155 (2006.01)
    РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) (11) (13) RU 2015 150 263 A (51) МПК A61K 31/155 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015150263, 01.05.2014 (71) Заявитель(и): НЕОКУЛИ ПТИ ЛТД (AU) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): 01.05.2013 AU 2013901517 ПЕЙДЖ Стефен (AU), ГАРГ Санджай (AU) (43) Дата публикации заявки: 06.06.2017 Бюл. № 16 RU (85) Дата начала рассмотрения заявки PCT на национальной фазе: 01.12.2015 (86) Заявка PCT: AU 2014/000480 (01.05.2014) 2015150263 (87) Публикация заявки PCT: WO 2014/176634 (06.11.2014) Адрес для переписки: 190000, Санкт-Петербург, Box-1125, "ПАТЕНТИКА" A (54) СПОСОБЫ ЛЕЧЕНИЯ БАКТЕРИАЛЬНЫХ ИНФЕКЦИЙ (57) Формула изобретения 1. Способ лечения или профилактики бактериальной колонизации или инфекции у субъекта, включающий стадию: введения субъекту терапевтически эффективного количества робенидина или его терапевтически приемлемой соли, причем указанная A бактериальная колонизация или инфекция вызвана бактериальным агентом. 2. Способ по п. 1, отличающийся тем, что субъект выбран из группы, включающей: человека, животных, принадлежащих видам семейства псовых, кошачьих, крупного рогатого скота, овец, коз, свиней, птиц, рыб и лошадей. 3. Способ по п. 1, отличающийся тем, что робенидин вводят субъекту в дозе в диапазоне от 0,1 до 250 мг/кг массы тела. 4. Способ по любому из пп. 1-3, отличающийся тем, что бактериальный агент является 2015150263 грамположительным. 5. Способ по п. 4, отличающийся тем, что бактериальный агент выбран из
    [Show full text]
  • Development of a Real-Time PCR for Identification of Brachyspira Species in Human Colonic Biopsies
    Development of a Real-Time PCR for Identification of Brachyspira Species in Human Colonic Biopsies Laurens J. Westerman1, Herbert V. Stel2, Marguerite E. I. Schipper3, Leendert J. Bakker4, Eskelina A. Neefjes-Borst5, Jan H. M. van den Brande6, Edwin C. H. Boel1, Kees A. Seldenrijk7, Peter D. Siersema8, Marc J. M. Bonten1, Johannes G. Kusters1* 1 Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands, 2 Department of Pathology, Tergooiziekenhuizen, Hilversum, The Netherlands, 3 Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands, 4 Central Laboratory for Bacteriology and Serology, Tergooiziekenhuizen, Hilversum, The Netherlands, 5 Department of Pathology, VU Medical Centre, Amsterdam, The Netherlands, 6 Department of Internal Medicine, Tergooiziekenhuizen, Hilversum, The Netherlands, 7 Department of Pathology, St. Antonius Hospital, Nieuwegein, Nieuwegein, The Netherlands, 8 Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands Abstract Background: Brachyspira species are fastidious anaerobic microorganisms, that infect the colon of various animals. The genus contains both important pathogens of livestock as well as commensals. Two species are known to infect humans: B. aalborgi and B. pilosicoli. There is some evidence suggesting that the veterinary pathogenic B. pilosicoli is a potential zoonotic agent, however, since diagnosis in humans is based on histopathology of colon biopsies, species identification is not routinely performed in human materials. Methods: The study population comprised 57 patients with microscopic evidence of Brachyspira infection and 26 patients with no histopathological evidence of Brachyspira infection. Concomitant faecal samples were available from three infected patients. Based on publically available 16S rDNA gene sequences of all Brachyspira species, species-specific primer sets were designed.
    [Show full text]
  • Biosafety Guidelines for Contained Use of Genetically Modified Microorganisms at Pilot and Industrial Scales
    Biosafety Guidelines for Contained Use of Genetically Modified Microorganisms at Pilot and Industrial Scales TECHNICAL BIOSAFETY COMMITTEE (TBC) NATIONAL CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (BIOTEC) NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (NSTDA) MINISTRY OF SCIENCE AND TECHNOLOGY (MOST) 2015 Biosafety Guidelines for Contained Use of Genetically Modified Microorganisms at Pilot and Industrial Scales TECHNICAL BIOSAFETY COMMITTEE (TBC) NATIONAL CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (BIOTEC) NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (NSTDA) MINISTRY OF SCIENCE AND TECHNOLOGY (MOST) 2015 Biosafety Guidelines for Contained Use of Genetically Modified Microorganisms at Pilot and Industrial Scales Technical Biosafety Committee National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency (NSTDA) © National Center for Genetic Engineering and Biotechnology 2015 ISBN : 978-616-12-0386-3 Tel : +66(0)2-564-6700 Fax : +66(0)2-564-6703 E-mail : [email protected] URL : http://www.biotec.or.th Printing House : P.A. Living Printing Co.,Ltd 4 Soi Sirintron 7 Road Sirintron District Bangplad Province Bangkok 10700 Tel : +66(0)2-881 9890 Fax : +66(0)2-881 9894 Preface Genetically Modified Microorganisms (GMMs) were first used in B.E. 2525 to produce insulin in industrial medicine. Currently, GMMs are used in various industries, such as the food, pharmaceutical and bioplastic industries, to manufacture a number of important consumer products. To ensure operator and environmental safety, the Technical Biosafety Committee (TBC) of the National Center for Genetic Engineering and Biotechnology (BIOTEC), the National Science and Technology Development Agency (NSTDA), has prepared guidelines for GMM work, publishing “Biosafety Guidelines for Contained Use of Genetically Modified Microorganisms at Pilot and Industrial Scales” in B.E.
    [Show full text]
  • Hydropotes Inermis Argyropus)
    ISSN (Print) 0023-4001 ISSN (Online) 1738-0006 Korean J Parasitol Vol. 54, No. 1: 87-91, February 2016 ▣ BRIEF COMMUNICATION http://dx.doi.org/10.3347/kjp.2016.54.1.87 Prevalence of Anaplasma and Bartonella spp. in Ticks Collected from Korean Water Deer (Hydropotes inermis argyropus) Jun-Gu Kang1, Sungjin Ko1, Heung-Chul Kim2, Sung-Tae Chong2, Terry A. Klein3, Jeong-Byoung Chae1, 1 4 5 6 7 1, Yong-Sun Jo , Kyoung-Seong Choi , Do-Hyeon Yu , Bae-Keun Park , Jinho Park , Joon-Seok Chae * 1Laboratory of Veterinary Internal Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea; 25th Medical Detachment, 168th Multifunctional Medical Battalion, 65th Medical Brigade, Unit 15247, APO AP96205-5247, USA; 3Public Health Command District-Korea, 65th Medical Brigade, Unit 15281, APO AP 96205-5281, USA; 4College of Ecology and Environmental Science, Kyungpook National University, Sangju 37224, Korea; 5College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea; 6College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea; 7College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Korea Abstract: Deer serve as reservoirs of tick-borne pathogens that impact on medical and veterinary health worldwide. In the Republic of Korea, the population of Korean water deer (KWD, Hydropotes inermis argyropus) has greatly increased from 1982 to 2011, in part, as a result of reforestation programs established following the Korean War when much of the land was barren of trees. Eighty seven Haemaphysalis flava, 228 Haemaphysalis longicornis, 8 Ixodes nipponensis, and 40 Ixodes persulcatus (21 larvae, 114 nymphs, and 228 adults) were collected from 27 out of 70 KWD.
    [Show full text]
  • Comparative Genomics to Investigate Genome Function and Adaptations in the Newly Sequenced Brachyspira Hyodysenteriae and Brachyspira Pilosicoli
    Comparative genomics to investigate genome function and adaptations in the newly sequenced Brachyspira hyodysenteriae and Brachyspira pilosicoli Phatthanaphong Wanchanthuek A Thesis presented for the degree of Doctor of Philosophy Murdoch University Australia March 2009 Dedication I would like to dedicate this dissertation to my family and my fiancée Ratchaneekorn. i Comparative genomics to investigate genome function and adaptations in the newly sequenced Brachyspira hyodysenteriae and Brachyspira pilosicoli Phatthanaphong Wanchanthuek Submitted for the degree of Doctor of Philosophy March 2009 ii ABSTRACT Brachyspira hyodysenteriae and Brachyspira pilosicoli are anaerobic intestinal spirochaetes that are the aetiological agents of swine dysentery and intestinal spirochaetosis, respectively. As part of this PhD study the genome sequence of B. hyodysenteriae strain WA1 and a near complete sequence of B. pilosicoli strain 95/1000 were obtained, and subjected to comparative genomic analysis. The B. hyodysenteriae genome consisted of a circular 3.0 Mb chromosome, and a 35,940 bp circular plasmid that has not previously been described. The incomplete genome of B. pilosicoli contained 4 scaffolds. There were 2,652 and 2,297 predicted ORFs in the B. hyodysenteriae and B. pilosicoli strains, respectively. Of the predicted ORFs, more had similarities to proteins of the enteric Clostridium species than they did to proteins of other spirochaetes. Many of these genes were associated with transport and metabolism, and they may have been gradually acquired through horizontal gene transfer in the environment of the large intestine. A construction of central metabolic pathways of the Brachyspira species identified a complete set of coding sequences for glycolysis, gluconeogenesis, a non‐oxidative pentose phosphate pathway, nucleotide metabolism and a respiratory electron transport chain.
    [Show full text]