Respiratory System 2=The Nasal Cavity: Consist of Three Main Parts
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Gross Anatomy Assignment Name: Olorunfemi Peace Toluwalase Matric No: 17/Mhs01/257 Dept: Mbbs Course: Gross Anatomy of Head and Neck
GROSS ANATOMY ASSIGNMENT NAME: OLORUNFEMI PEACE TOLUWALASE MATRIC NO: 17/MHS01/257 DEPT: MBBS COURSE: GROSS ANATOMY OF HEAD AND NECK QUESTION 1 Write an essay on the carvernous sinus. The cavernous sinuses are one of several drainage pathways for the brain that sits in the middle. In addition to receiving venous drainage from the brain, it also receives tributaries from parts of the face. STRUCTURE ➢ The cavernous sinuses are 1 cm wide cavities that extend a distance of 2 cm from the most posterior aspect of the orbit to the petrous part of the temporal bone. ➢ They are bilaterally paired collections of venous plexuses that sit on either side of the sphenoid bone. ➢ Although they are not truly trabeculated cavities like the corpora cavernosa of the penis, the numerous plexuses, however, give the cavities their characteristic sponge-like appearance. ➢ The cavernous sinus is roofed by an inner layer of dura matter that continues with the diaphragma sellae that covers the superior part of the pituitary gland. The roof of the sinus also has several other attachments. ➢ Anteriorly, it attaches to the anterior and middle clinoid processes, posteriorly it attaches to the tentorium (at its attachment to the posterior clinoid process). Part of the periosteum of the greater wing of the sphenoid bone forms the floor of the sinus. ➢ The body of the sphenoid acts as the medial wall of the sinus while the lateral wall is formed from the visceral part of the dura mater. CONTENTS The cavernous sinus contains the internal carotid artery and several cranial nerves. Abducens nerve (CN VI) traverses the sinus lateral to the internal carotid artery. -
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor: Rebecca Bailey 1 Chapter 1 The Human Body: An Orientation • Terms - Anatomy: the study of body structure and relationships among structures - Physiology: the study of body function • Levels of Organization - Chemical level 1. atoms and molecules - Cells 1. the basic unit of all living things - Tissues 1. cells join together to perform a particular function - Organs 1. tissues join together to perform a particular function - Organ system 1. organs join together to perform a particular function - Organismal 1. the whole body • Organ Systems • Anatomical Position • Regional Names - Axial region 1. head 2. neck 3. trunk a. thorax b. abdomen c. pelvis d. perineum - Appendicular region 1. limbs • Directional Terms - Superior (above) vs. Inferior (below) - Anterior (toward the front) vs. Posterior (toward the back)(Dorsal vs. Ventral) - Medial (toward the midline) vs. Lateral (away from the midline) - Intermediate (between a more medial and a more lateral structure) - Proximal (closer to the point of origin) vs. Distal (farther from the point of origin) - Superficial (toward the surface) vs. Deep (away from the surface) • Planes and Sections divide the body or organ - Frontal or coronal 1. divides into anterior/posterior 2 - Sagittal 1. divides into right and left halves 2. includes midsagittal and parasagittal - Transverse or cross-sectional 1. divides into superior/inferior • Body Cavities - Dorsal 1. cranial cavity 2. vertebral cavity - Ventral 1. lined with serous membrane 2. viscera (organs) covered by serous membrane 3. thoracic cavity a. two pleural cavities contain the lungs b. pericardial cavity contains heart c. the cavities are defined by serous membrane d. -
The Olfactory Receptor Associated Proteome
INTERNATIONAL GRADUATE SCHOOL OF NEUROSCIENCES (IGSN) RUHR UNIVERSITÄT BOCHUM THE OLFACTORY RECEPTOR ASSOCIATED PROTEOME Doctoral Dissertation David Jonathan Barbour Department of Cell Physiology Thesis advisor: Prof. Dr. Dr. Dr. Hanns Hatt Bochum, Germany (30.12.05) ABSTRACT Olfactory receptors (OR) are G-protein-coupled membrane receptors (GPCRs) that comprise the largest vertebrate multigene family (~1,000 ORs in mouse and rat, ~350 in human); they are expressed individually in the sensory neurons of the nose and have also been identified in human testis and sperm. In order to gain further insight into the underlying molecular mechanisms of OR regulation, a bifurcate proteomic strategy was employed. Firstly, the question of stimulus induced plasticity of the olfactory sensory neuron was addressed. Juvenile mice were exposed to either a pulsed or continuous application of an aldehyde odorant, octanal, for 20 days. This was followed by behavioural, electrophysiological and proteomic investigations. Both treated groups displayed peripheral desensitization to octanal as determined by electro-olfactogram recordings. This was not due to anosmia as they were on average faster than the control group in a behavioural food discovery task. To elucidate differentially regulated proteins between the control and treated mice, fluorescent Difference Gel Electrophoresis (DIGE) was used. Seven significantly up-regulated and ten significantly down-regulated gel spots were identified in the continuously treated mice; four and twenty-four significantly up- and down-regulated spots were identified for the pulsed mice, respectively. The spots were excised and proteins were identified using mass spectrometry. Several promising candidate proteins were identified including potential transcription factors, cytoskeletal proteins as well as calcium binding and odorant binding proteins. -
The Pattern of Olfactory Innervation by W
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.9.3.101 on 1 July 1946. Downloaded from THE PATTERN OF OLFACTORY INNERVATION BY W. E. LE GROS CLARK and R. T. TURNER WARWICK From the Department of Anatomy, University of Oxford (RECEIVED 31ST JULY, 1946) IT is desirable that, from time to time, commonly Methods accepted statements regarding anatomical pathways Most of the observations recorded in this paper were and connexions in the peripheral and central nervous made on rabbit material. The fixation of the olfactory systems should be carefully reviewed in the light of mucosa presented considerable difficulty. The method modern technical methods of investigation, for it finally selected, because it gave the best results with must be admitted that not a few of these statements protargol and was also adequate for the other stains are based on old methods which are now recognized employed, was perfusion of 70 per cent. alcohol through to be too crude to permit of really accurate con- the aorta, after preliminary washing through with normal clusions. In recent years, indeed, a number of saline, as recommended by Bodian (1936). Another facts have been shown unexpected difficulty arose from the fact that a large apparently well-established number of laboratory rabbits suffer from a chronic by critical studies to be erroneous. For example, rhinitis which leads to gross pathological changes in the the so-called ventral nucleus of the lateral geniculate olfactory mucosa. Consequently, a considerable pro- Protected by copyright. body and the pulvinar are no longer accepted as portion of our material, experimental and otherwise, terminal stations of the optic tract, and the strie had to be discarded as useless. -
Macroscopic Anatomy of the Nasal Cavity and Paranasal Sinuses of the Domestic Pig (Sus Scrofa Domestica) Daniel John Hillmann Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1971 Macroscopic anatomy of the nasal cavity and paranasal sinuses of the domestic pig (Sus scrofa domestica) Daniel John Hillmann Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Animal Structures Commons, and the Veterinary Anatomy Commons Recommended Citation Hillmann, Daniel John, "Macroscopic anatomy of the nasal cavity and paranasal sinuses of the domestic pig (Sus scrofa domestica)" (1971). Retrospective Theses and Dissertations. 4460. https://lib.dr.iastate.edu/rtd/4460 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. 72-5208 HILLMANN, Daniel John, 1938- MACROSCOPIC ANATOMY OF THE NASAL CAVITY AND PARANASAL SINUSES OF THE DOMESTIC PIG (SUS SCROFA DOMESTICA). Iowa State University, Ph.D., 1971 Anatomy I University Microfilms, A XEROX Company, Ann Arbor. Michigan I , THIS DISSERTATION HAS BEEN MICROFILMED EXACTLY AS RECEIVED Macroscopic anatomy of the nasal cavity and paranasal sinuses of the domestic pig (Sus scrofa domestica) by Daniel John Hillmann A Dissertation Submitted to the Graduate Faculty in Partial Fulfillment of The Requirements for the Degree of DOCTOR OF PHILOSOPHY Major Subject: Veterinary Anatomy Approved: Signature was redacted for privacy. h Charge of -^lajoï^ Wor Signature was redacted for privacy. For/the Major Department For the Graduate College Iowa State University Ames/ Iowa 19 71 PLEASE NOTE: Some Pages have indistinct print. -
Odorant-Binding Protein: Localization to Nasal Glands and Secretions (Olfaction/Mucus/Immunohistochemistry/Pyrazines) JONATHAN PEVSNER, PAMELA B
Proc. Nail. Acad. Sci. USA Vol. 83, pp. 4942-4946, July 1986 Neurobiology Odorant-binding protein: Localization to nasal glands and secretions (olfaction/mucus/immunohistochemistry/pyrazines) JONATHAN PEVSNER, PAMELA B. SKLAR, AND SOLOMON H. SNYDER* Departments of Neuroscience, Pharmacology, and Experimental Therapeutics, Psychiatry, and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 Contributed by Solomon H. Snyder, January 6, 1986 ABSTRACT An odorant-binding protein (OBP) was iso- formed at an antiserum dilution of 1:8100 in 0.1 M Tris HCl, lated from bovine olfactory and respiratory mucosa. We have pH 8.0/0.5% Triton X-100, in a final vol of50 A.l. Incubations produced polyclonal antisera to this protein and report its were carried out at 370C for 90 min with 35,000 cpm of immunohistochemical localization to mucus-secreting glands of '251-labeled OBP per tube. Immunoprecipitation was accom- the olfactory and respiratory mucosa. Although OBP was plished by using 25 1LI of 5% Staphylococcus aureus cells originally isolated as a pyrazine binding protein, both rat and (Calbiochem) in 0.1 M Tris HCl (pH 8.0) at 370C for 30 min. bovine OBP also bind the odorants [3H]methyldihydrojasmon- Bound 1251I-labeled OBP was separated from free OBP by ate and 3,7-dimethyl-octan-1-ol as well as 2-isobutyl-3-[3HI filtration over glass fiber filters (No. 32, Schleicher & methoxypyrazine. We detect substantial odorant-binding ac- Schuell) pretreated with 10% fetal bovine serum, using a tivity attributable to OBP in secreted rat nasal mucus and tears Brandel cell harvester (Brandel, Gaithersburg, MD). -
Chapter 17: the Special Senses
Chapter 17: The Special Senses I. An Introduction to the Special Senses, p. 550 • The state of our nervous systems determines what we perceive. 1. For example, during sympathetic activation, we experience a heightened awareness of sensory information and hear sounds that would normally escape our notice. 2. Yet, when concentrating on a difficult problem, we may remain unaware of relatively loud noises. • The five special senses are: olfaction, gustation, vision, equilibrium, and hearing. II. Olfaction, p. 550 Objectives 1. Describe the sensory organs of smell and trace the olfactory pathways to their destinations in the brain. 2. Explain what is meant by olfactory discrimination and briefly describe the physiology involved. • The olfactory organs are located in the nasal cavity on either side of the nasal septum. Figure 17-1a • The olfactory organs are made up of two layers: the olfactory epithelium and the lamina propria. • The olfactory epithelium contains the olfactory receptors, supporting cells, and basal (stem) cells. Figure 17–1b • The lamina propria consists of areolar tissue, numerous blood vessels, nerves, and olfactory glands. • The surfaces of the olfactory organs are coated with the secretions of the olfactory glands. Olfactory Receptors, p. 551 • The olfactory receptors are highly modified neurons. • Olfactory reception involves detecting dissolved chemicals as they interact with odorant-binding proteins. Olfactory Pathways, p. 551 • Axons leaving the olfactory epithelium collect into 20 or more bundles that penetrate the cribriform plate of the ethmoid bone to reach the olfactory bulbs of the cerebrum where the first synapse occurs. • Axons leaving the olfactory bulb travel along the olfactory tract to reach the olfactory cortex, the hypothalamus, and portions of the limbic system. -
Surgical Interventions for Inferior Turbinate Hypertrophy: a Comprehensive Review of Current Techniques and Technologies
International Journal of Environmental Research and Public Health Review Surgical Interventions for Inferior Turbinate Hypertrophy: A Comprehensive Review of Current Techniques and Technologies Baharudin Abdullah * and Sharanjeet Singh Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia; [email protected] * Correspondence: [email protected] Abstract: Surgical treatment of the inferior turbinates is required for hypertrophic inferior turbinates refractory to medical treatments. The main goal of surgical reduction of the inferior turbinate is to relieve the obstruction while preserving the function of the turbinate. There have been a variety of surgical techniques described and performed over the years. Irrespective of the techniques and technologies employed, the surgical techniques are classified into two types, the mucosal-sparing and non-mucosal-sparing, based on the preservation of the medial mucosa of the inferior turbinates. Although effective in relieving nasal block, the non-mucosal-sparing techniques have been associated with postoperative complications such as excessive bleeding, crusting, pain, and prolonged recovery period. These complications are avoided in the mucosal-sparing approach, rendering it the preferred option. Although widely performed, there is significant confusion and detachment between current practices and their basic objectives. This conflict may be explained by misperception over the myriad Citation: Abdullah, B.; Singh, S. Surgical Interventions for Inferior of available surgical techniques and misconception of the rationale in performing the turbinate Turbinate Hypertrophy: A reduction. A comprehensive review of each surgical intervention is crucial to better define each Comprehensive Review of Current procedure and improve understanding of the principle and mechanism involved. -
Bifid and Secondary Superior Nasal Turbinates M.C
View metadata, citation and similar papers at core.ac.uk brought to you by CORE Foliaprovided Morphol. by Via Medica Journals Vol. 78, No. 1, pp. 199–203 DOI: 10.5603/FM.a2018.0047 C A S E R E P O R T Copyright © 2019 Via Medica ISSN 0015–5659 journals.viamedica.pl Bifid and secondary superior nasal turbinates M.C. Rusu1, M. Săndulescu1, C.J. Sava2, D. Dincă3 1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2“Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania 3“Ovidius” University, Aleea Universității No. 1, Constanța, Romania [Received: 5 March 2018; Accepted: 8 May 2018] The lateral nasal wall contains the nasal turbinates (conchae) which are used as landmarks during functional endoscopic surgery. Various morphological pos- sibilities of turbinates were reported, such as bifidity of the inferior turbinate and extra middle turbinates, such as the secondary middle turbinate. During a retrospective cone beam computed tomography study of nasal turbinates in a patient we found previously unreported variants of the superior nasal turbina- tes. These had, bilaterally, ethmoidal and sphenoidal insertions. On the right side we found a bifid superior turbinate and on the left side we found a secondary superior turbinate located beneath the normal/principal one, in the superior nasal meatus. These demonstrate that if a variant morphology is possible for a certain turbinate, it could occur in any nasal turbinate but it has not been yet observed or reported. (Folia Morphol 2019; 78, 1: 199–203) Key words: nasal fossa, nasal concha, bifid turbinate, secondary turbinate, sphenoethmoidal recess INTRODUCTION Paranasal sinuses as well as several regions of the The lateral nasal wall contains the nasal conchae orbit may be accessed through the lateral nasal wall, or turbinates. -
Role of Human Papilloma Virus in the Etiology of Primary Malignant Sinonasal Tumors
ROLE OF HUMAN PAPILLOMA VIRUS IN THE ETIOLOGY OF PRIMARY MALIGNANT SINONASAL TUMORS A DISSERTATION SUBMITTED IN PARTIAL FULFILLMENT OF M.S BRANCH –IV (OTORHINOLARYNGOLOGY) EXAMINATION OF THE TAMILNADU DR.MGR MEDICAL UNIVERSITY TO BE HELD IN APRIL 2016 | P a g e ROLE OF HUMAN PAPILLOMA VIRUS IN THE ETIOLOGY OF PRIMARY MALIGNANT SINONASAL TUMORS A DISSERTATION SUBMITTED IN PARTIAL FULFILLMENT OF M.S BRANCH –IV (OTORHINOLARYNGOLOGY) EXAMINATION OF THE TAMILNADU DR.MGR MEDICAL UNIVERSITY TO BE HELD IN APRIL 2016 | P a g e CERTIFICATE This is to certify that the dissertation entitled ‘ROLE OF HUMAN PAPILLOMA VIRUS IN THE ETIOLOGY OF PRIMARY MALIGNANT SINONASAL TUMORS’ is a bonafide original work of Dr Miria Mathews, carried out under my guidance, in partial fulfilment of the rules and regulations for the MS Branch IV, Otorhinolaryngology examination of The Tamil Nadu Dr. M.G.R Medical University to be held in April 2016. Dr Rajiv Michael Guide Professor and Head of Unit – ENT 1 Department of ENT Christian Medical College Vellore | P a g e CERTIFICATE This is to certify that the dissertation entitled ‘ROLE OF HUMAN PAPILLOMA VIRUS IN THE ETIOLOGY OF PRIMARY MALIGNANT SINONASAL TUMORS’ is a bonafide original work of Dr Miria Mathews, in partial fulfilment of the rules and regulations for the MS Branch IV, Otorhinolaryngology examination of The Tamil Nadu Dr. M.G.R Medical University to be held in April 2016. Dr Alfred Job Daniel Dr John Mathew Principal Professor and Head Christian Medical College Department of Otorhinolaryngology Vellore Christian Medical College Vellore | P a g e CERTIFICATE This is to certify that the dissertation entitled ‘ROLE OF HUMAN PAPILLOMA VIRUS IN THE ETIOLOGY OF PRIMARY MALIGNANT SINONASAL TUMORS’ is a bonafide original work in partial fulfilment of the rules and regulations for the MS Branch IV, Otorhinolaryngology examination of The Tamil Nadu Dr. -
Basal Cells. These Are Small Cells That Do Not Reach the Surface
B.SC - Semester 2 (Core course – Theory) Course Code – 1ZOOTC0201 Course Title - Comparative anatomy and developmental biology of vertebrates UNIT: 4 Topic : Olfactoreceptors (Organ of smell) The receptors for smell occur in the olfactory epithelium which lines the nasal sacs and open out by external nares and may also open into the buccal cavity or pharynx by internal nares Structure Olfactory epithelium is a modified pseudo stratified epithelium having three types of cell 1) Receptor cells. They are spindle –shaped bipolar neurons with rounded nuclei in the middle wide region .they are ectodermal in origin. Dendrine of an olfactory cell extends to the surface of the epithelium where it enlarges into an olfactory vesicle which bears a few (5 to12) shorts nonmotile cilia or olfactory hair,each about 2 micrometer long .the no. of olfactory here varies with the species. The olfactory vesicle contains tiny granules, one at base of each cilium, looking like the basal bodies in the ciliated cells. The unmyelinated axons start from the opposite end of the olfactory cell, from the olfactory nerves which make a direct contact with the olfactory bulb of the brain, from here, bundles of nerves fibers extended via olfactory tract to the smell center in the cerebral cortex. The olfactory cells serving as sensory receptors as well as conducting neuron. The neuron carries the impulse directly to the brain without the need of other nerve cells called nerve fibers to relay the impulse. 2) Supporting cells. These are columnar cells with oval nuclei they lie between the olfactory cell to support them. -
Giant Angiomatous Choanal Polyp Originating from the Middle Turbinate: a Case Report
Case Report ENT Updates 2017;7(1):53–56 doi:10.2399/jmu.2017001007 Giant angiomatous choanal polyp originating from the middle turbinate: a case report Aleksandar Perić1, Aleksandar Jovanovski2, Biserka Vukomanović Durdević3 1Department of Otorhinolaryngology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia 2Institute for Radiology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia 3Institute for Pathology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia Abstract Özet: Orta konkadan kaynaklanan dev anjiyomatöz koanal polip: Olgu sunumu Choanal polyps (CPs) can be defined as histologically benign, solitary, Koanal polip (KP) histolojik olarak benign, nazal kavite ile nazofarenks soft tissue lesions extending towards the junction between the nasal cavi- aras› birleflme noktas›na koana yoluyla uzanan, soliter yumuflak doku ty and the nasopharynx through the choana. They usually originate from lezyonu olarak tan›mlan›r. Genellikle maksiller sinüsten köken al›r. Bu the maxillary sinus. In this report, we present an unusual case of a giant olgu sunumunda orta konkan›n alt bölümünden ç›kan ve nazofarenksi angiomatous CP arising from the inferior part of the middle turbinate tamamen dolduran ola¤and›fl› bir dev anjiyomatöz KP’yi sunmaktay›z. that completely filled the nasopharynx. A 24-year-old man presented with Burnun sol taraf›nda t›kanma, burun ak›nt›s› ve hafif-orta derecede bu- five-year history of left-sided nasal obstruction, nasal discharge and mild- run kanamas› üzerine 5 y›ll›k öyküsü olan 24 yafl›ndaki erkek hasta kli- to-moderate epistaxis. The diagnosis was supported by contrast- ni¤imize baflvurdu. Tan›, paranazal sinüslerin kontrastl› bilgisayarl› to- enhanced computed tomography scan of the paranasal sinuses with mografi taramas›yla kombine anjiyografiyle desteklendi ve histopatolo- angiography and confirmed by histopathological examination.