40TH FEBS CONGRESS the Biochemical Basis of Life
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Wellcome Four Year Phd Programme in Integrative Cell Mechanisms
2021 Wellcome Four Year PhD Programme in Integrative Cell Mechanisms Training the next generation of Molecular Cell Biologists Background and Aims of Programme The Wellcome Four Year PhD Programme in Integrative Cell Mechanisms (iCM) is closely associated with the Wellcome Centre for Cell Biology and trains the next generation of cell and molecular biologists in the application of quantitative methods to understand the inner workings of distinct cell types in different settings. A detailed understanding of normal cellular function is required to investigate the molecular cause of disease and design future treatments. However, data generated by biological research requires increasingly complex analysis with technological advances in sequencing, mass spectrometry/proteomics, super-resolution microscopy, Wellcome Centre for Cell Biology 2021 synthetic and structural biology generating increasingly large, complex datasets. In addition, innovations in computer sciences and informatics are transforming data acquisition and analysis and breakthroughs in physics, chemistry and engineering allow the development of devices, molecules and instruments that drive the biological data revolution. Exploiting technological advances to transform our understanding of cellular mechanisms will require scientists who have been trained across the distinct disciplines of natural sciences, engineering, informatics and mathematics. To address this training need, iCM PhD projects are cross-disciplinary involving two primary supervisors with complementary expertise. Supervisor partnerships pair quantitative scientists with cell biologists ensuring that students develop pioneering cross-disciplinary collaborative projects to uncover cellular mechanisms relevant to health and disease. We aim to recruit students with a variety of backgrounds across the biological and physical sciences, including Biochemistry, Biomedical Science, Cell Biology, Chemistry, Computational Data Sciences, Engineering, Genetics, Mathematics, Molecular Biology and Physics. -
IOBC/WPRS Working Group “Integrated Plant Protection in Fruit
IOBC/WPRS Working Group “Integrated Plant Protection in Fruit Crops” Subgroup “Soft Fruits” Proceedings of Workshop on Integrated Soft Fruit Production East Malling (United Kingdom) 24-27 September 2007 Editors Ch. Linder & J.V. Cross IOBC/WPRS Bulletin Bulletin OILB/SROP Vol. 39, 2008 The content of the contributions is in the responsibility of the authors The IOBC/WPRS Bulletin is published by the International Organization for Biological and Integrated Control of Noxious Animals and Plants, West Palearctic Regional Section (IOBC/WPRS) Le Bulletin OILB/SROP est publié par l‘Organisation Internationale de Lutte Biologique et Intégrée contre les Animaux et les Plantes Nuisibles, section Regionale Ouest Paléarctique (OILB/SROP) Copyright: IOBC/WPRS 2008 The Publication Commission of the IOBC/WPRS: Horst Bathon Luc Tirry Julius Kuehn Institute (JKI), Federal University of Gent Research Centre for Cultivated Plants Laboratory of Agrozoology Institute for Biological Control Department of Crop Protection Heinrichstr. 243 Coupure Links 653 D-64287 Darmstadt (Germany) B-9000 Gent (Belgium) Tel +49 6151 407-225, Fax +49 6151 407-290 Tel +32-9-2646152, Fax +32-9-2646239 e-mail: [email protected] e-mail: [email protected] Address General Secretariat: Dr. Philippe C. Nicot INRA – Unité de Pathologie Végétale Domaine St Maurice - B.P. 94 F-84143 Montfavet Cedex (France) ISBN 978-92-9067-213-5 http://www.iobc-wprs.org Integrated Plant Protection in Soft Fruits IOBC/wprs Bulletin 39, 2008 Contents Development of semiochemical attractants, lures and traps for raspberry beetle, Byturus tomentosus at SCRI; from fundamental chemical ecology to testing IPM tools with growers. -
Development of Chemical Methods for Individual
Eastern-European Journal of Enterprise Technologies ISSN 1729-3774 2/6 ( 98 ) 2019 TECHNOLOGY ORGANIC AND INORGANIC SUBSTANCES UDC 615.1: 66.06: 504.5 На прикладі деконтамінації параоксону (O,O-діетил-O- DOI: 10.15587/1729-4061.2019.161208 4-нітрофенілфосфату) та метилпаратіону (O,O-диметил- O-4-нітрофенілтіофосфату) з твердих поверхонь (металу, тканини, пластику) досліджено методи індивідуального знеза- раження фосфорорганічних естерів нервово-паралітичної дії. DEVELOPMENT Як дегазаційні системи було вивчено суміші гідропериту, борної кислоти, цетилпіридиній хлориду та монтморилонітової нано- глини. Показано, що застосування міцелярної системи разом OF CHEMICAL з наноглинами суттєво підвищує ступінь адсорбції фосфорор- ганічних субстратів із зараженої поверхні. При цьому присут- METHODS FOR ність у системах з гідроперитом активатора (борної кислоти) сприяє збільшенню швидкості реакції у міцелярному середовищі INDIVIDUAL майже у 20 разів в порівнянні з системами без активації. Встановлено, що у досліджених міцелярних системах збе- DECONTAMINATION рігається супернуклеофільність НОО--аніону по відношенню до електрофільних субстратів – параоксону та метилпа- OF ORGANO- ратіону. Зроблено висновок, що присутність монтморило- ніту (натрій- та органомодифікованого) збільшує величину α-ефек ту, як у системах тільки с гідроперитом, так і в систе- PHOSPHORUS мах з активатором борною кислотою. Встановлено ефект прискорення похідними монтморилоніту COMPOUNDS процесу розкладання фосфорорганічних субстратів в міцеляр- ному середовищу. Цей факт може бути використаний при кон- струюванні «зелених» деконтамінаційних систем швидкої дії. L. Vakhitova Аналіз даних щодо швидкості дезактивації параоксону та PhD, Senior Researcher* метилпаратіону на твердих поверхнях в досліджених міцеляр- V. Bessarabov них деконтамінаційних системах дозволив обрати як опти- PhD, Associate Professor** мальну систему на основі гідропериту, борної кислоти, цетил- E-mail: [email protected] піридиній хлориду та органомодифікованого монтморилоніту. -
EMBO Conference on Fission Yeast: Pombe 2013 7Th International Fission Yeast Meeting London, United Kingdom, 24 - 29 June 2013
Abstracts of papers presented at the EMBO Conference on Fission Yeast: pombe 2013 7th International Fission Yeast Meeting London, United Kingdom, 24 - 29 June 2013 Meeting Organizers: Jürg Bähler UCL, UK Jacqueline Hayles CRUK-LRI, UK Scientific Programme: Robin Allshire UK Rob Martienssen USA Paco Antequera Spain Hisao Masai Japan Francois Bachand Canada Jonathan Millar UK Jürg Bähler UK Sergio Moreno Spain Pernilla Bjerling Sweden Jo Murray UK Fred Chang USA Toru Nakamura USA Gordon Chua Canada Chris Norbury UK Peter Espenshade USA Kunihiro Ohta Japan Kathy Gould USA Snezhka Oliferenko Singapore Juraj Gregan Austria Janni Petersen UK Edgar Hartsuiker UK Paul Russell USA Jacqueline Hayles UK Geneviève Thon Denmark Elena Hidalgo Spain Iva Tolic-Nørrelykke Germany Charlie Hoffman USA Elizabeth Veal UK Zoi Lygerou Greece Yoshi Watanabe Japan Henry Levin USA Jenny Wu France These abstracts may not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the authors. Printed by SLS Print, London, UK Page 1 Poster Prize Judges: Coordinated by Sara Mole & Mike Bond UCL, UK Poster Prizes sponsored by UCL, London’s Global University Rosa Aligué Spain Hiroshi Murakami Japan José Ayté Spain Eishi Noguchi USA Hugh Cam USA Martin Převorovský Czech Republic Rafael Daga Spain Luis Rokeach Canada Jacob Dalgaard UK Ken Sawin UK Da-Qiao Ding Japan Melanie Styers USA Tim Humphrey UK Irene Tang USA Norbert Käufer Germany Masaru Ueno Japan Makoto Kawamukai Japan -
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Revista de Biología Tropical, ISSN: 2215-2075, Vol. 69(2): 545-556, April-June 2021 (Published Apr. 19, 2021) 545 Rostelato-Ferreira, S., Vettorazzo, O.B., Tribuiani, N., Leal, A.P., Dal Belo, C.A., Rodrigues-Simioni, L., Floriano, R.S., Oshima- Franco, Y. (2021). Action of heparin and acetylcholine modulators on the neurotoxicity of the toad Rhinella schneideri (Anura: Bufonidae) in Brazil. Revista de Biología Tropical, 69(2), 545- 556. DOI 10.15517/rbt.v69i2.44539 DOI 10.15517/rbt.v69i2.44539 Action of heparin and acetylcholine modulators on the neurotoxicity of the toad Rhinella schneideri (Anura: Bufonidae) in Brazil Sandro Rostelato-Ferreira1,2; Orcid: 0000-0002-8987-434X Orlando B. Vettorazzo2; Orcid: 0000-0003-4731-4771 Natália Tribuiani2; Orcid: 0000-0002-7661-475X Allan P. Leal3; Orcid: 0000-0002-4689-4615 Cháriston A. Dal Belo3,4; Orcid: 0000-0001-7010-650 Léa Rodrigues-Simioni5; Orcid: 0000-0002-8712-6639 Rafael S. Floriano6; Orcid: 0000-0003-0759-5863 Yoko Oshima-Franco2*; Orcid: 0000-0002-4972-8444 1. Institute of Health Sciences, Paulista University (UNIP), Sorocaba, São Paulo, Brazil; [email protected] 2. Graduate Program in Pharmaceutical Sciences, University of Sorocaba (UNISO), Sorocaba, São Paulo, Brazil; [email protected], [email protected], [email protected] (*Correspondence) 3. Graduate Program in Toxicological Biochemistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil; [email protected] 4. Laboratory of Neurobiology and Toxinology (Lanetox), Federal University of Pampa (UNIPAMPA), São Gabriel, Rio Grande do Sul, Brazil; [email protected] 5. Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-970, São Paulo, Brazil; [email protected] 6. -
Pulse Crops of the World and Their Important Insect Pests.
u* ,'Eti:ati brary TJTU OF THESIS/TITRE DE LA TH& "Pulse Crops of the World and their Important Insect pestsw UN~VERS~~/~N~VERSIT~ Simon Fraser University 1 DEGREE FOR WHICH THESIS WAS SENTEW. cnmEpour Mom mm $5 wTPR~SENT~E . *aster of pest ~mag-nt NAME OF WlSOR/NOW DU DIRECTEUR DE THiSE J-M* Permission is hereby grated to the NATI~ALLIBRARY OF Llutwisdtion m,b.r I# prdssnte, wcordde b I~@BUOTH&- CANADA to microfilm this thesis and to lend or sell mpin QUE NATIONALF DU C.)NADA ds mi0r dketMss et C of the film. * de prbter w do v'sndio dss sxemplsirrs du film The author lsrsus aha publication rights, ad neither the . f'a& re r4s.m /eg 4utms d. p(rblic8tion: nl h wise mpr&ced without the wthor's mitten permissiar. IMPORTANT INSECT PESTS Carl Edmond Japlin R B.A., Antioch College, 1973 - A PROJECT SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF PEST MANAGEHENT in the Department , of' . - 4 F+ , @ Carl Edmond Joplin Simon F~aaerUniversity -8 -d. - - - - - -- - -- .-- -, 197'4 = _ s -- -- -- -- -- -- -- --- - -- % All ,rights reserved. This the848 'may not be reproduced in-whole or in part by photocopy or other'means, without permission of the author. APPROVAL . Name: -Carl Edmond Joplin L Degree: Master of Pest Management Title of Project: Pulse Crops of the World and their Important Insect Pests Examining Committee: , r*. Chairman: John S. Barlow L -- Johii M. Webster Senior Supervisor Thelma 'Finlayson dames E. She * Hubert R. Kwarthy Head, Entomology Section Vancouver gesearch sf at ion Agriculture Canada Date Approved : ! /?74 c . -
The Impact of Multiple Climatic and Geographic Factors on the Chemical Defences of Asian Toads (Bufo Gargarizans Cantor)
www.nature.com/scientificreports OPEN The impact of multiple climatic and geographic factors on the chemical defences of Asian toads (Bufo gargarizans Cantor) Yueting Cao, Keke Cui, Hongye Pan, Jiheng Wu & Longhu Wang* Chemical defences are widespread in nature, yet we know little about whether and how climatic and geographic factors afect their evolution. In this study, we investigated the natural variation in the concentration and composition of the main bufogenin toxin in adult Asian toads (Bufo gargarizans Cantor) captured in twenty-two regions. Moreover, we explored the relative importance of eight climatic factors (average temperature, maximum temperature, minimum temperature, average relative humidity, 20–20 time precipitation, maximum continuous precipitation, maximum ground temperature, and minimum ground temperature) in regulating toxin production. We found that compared to toads captured from central and southwestern China, toads from eastern China secreted higher concentrations of cinobufagin (CBG) and resibufogenin (RBG) but lower concentrations of telocinobufagin (TBG) and cinobufotalin (CFL). All 8 climatic variables had signifcant efects on bufogenin production (ri>0.5), while the plastic response of bufogenin toxin to various climate factors was highly variable. The most important climatic driver of total bufogenin production was precipitation: the bufogenin concentration increased with increasing precipitation. This study indicated that the evolution of phenotypic plasticity in chemical defences may depend at least partly on the geographic variation of defensive toxins and their climatic context. Chemical defences is ubiquitous in nature and can serve for deterring predators, competitors, parasites, and path- ogens1–3. Many species can secrete a large diversity of toxic defensive compounds for self-protection. -
Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis
International Journal of Molecular Sciences Review Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis Natalia I. Agalakova 1, Nikolai I. Kolodkin 2, C. David Adair 3 , Alexander P. Trashkov 4 and Alexei Y. Bagrov 1,* 1 Sechenov Institute of Evolutionary Physiology and Biochemistry, 44 Torez Prospect, 194223 St. Petersburg, Russia; [email protected] 2 State Institute of Highly Pure Biopreparations and Sechenov Institute of Evolutionary Physiology and Biochemistry, 44 Torez Prospect, 194223 St. Petersburg, Russia; [email protected] or [email protected] 3 Department of Obstetrics and Gynecology, University of Tennessee, Chattanooga, TN 37402, USA; [email protected] or [email protected] 4 Konstantinov St. Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, 1 Orlova Roshcha, 188300 Gatchina, Russia; [email protected] * Correspondence: [email protected] Abstract: Despite prophylaxis and attempts to select a therapy, the frequency of preeclampsia does not decrease and it still takes the leading position in the structure of maternal mortality and morbidity worldwide. In this review, we present a new theory of the etiology and pathogenesis of preeclampsia that is based on the interaction of Na/K-ATPase and its endogenous ligands in- cluding marinobufagenin. The signaling pathway of marinobufagenin involves an inhibition of transcriptional factor Fli1, a negative regulator of collagen synthesis, followed by the deposition of collagen in the vascular tissues and altered vascular functions. Moreover, in vitro and in vivo neutralization of marinobufagenin is associated with the restoration of Fli1. The inverse relationship Citation: Agalakova, N.I.; Kolodkin, between marinobufagenin and Fli1 opens new possibilities in the treatment of cancer; as Fli1 is N.I.; Adair, C.D.; Trashkov, A.P.; a proto-oncogene, a hypothesis on the suppression of Fli1 by cardiotonic steroids as a potential Bagrov, A.Y. -
Laboratory Harbor Spring Cold Annual Report 1990
YEAR CENTENNIAL THE LABORATORY HARBOR SPRING COLD ANNUAL REPORT 1990 COLD SPRING HARBOR LABORATORY THE CENTENNIAL YEAR ANNUAL REPORT 1990 Cold Spring Harbor Laboratory Box 100 1 Bungtown Road Cold Spring Harbor, New York 11724 Book design Emily Harste Editors Dorothy Brown, Lee Martin Photography Margot Bennett, Herb Parsons, Edward Campodonico Typography Marie Sullivan Front cover: Jones Laboratory, during the Centennial fireworks dis- play. This building, completed in 1893, was the first structure built expressly for science at Cold Spring Harbor. (Photograph by Ross Meurer and Margot Bennett.) Back Cover: (Top) Centennial reenactment of the first biology class at Cold Spring Harbor on board the launch "Rotifer." (Inset) The original class of 1890. Reenactments for the Centennial were directed by Rob Gensel. (Photograph by Randy Wilfong.) (Bottom) Centennial reenactment of the Laboratory's first biology class on the Jones Laboratory porch. (Inset) The original 1890 class on the porch of the old Fish Hatchery building before the completion of Jones Laboratory. (Photograph by Margot Bennett.) Contents Officers of the Corporation/Board of Trustees v Governance and Major Affiliations vi Committees vii Edward Pulling (1898-1991)viii DIRECTOR'S REPORT DEPARTMENTAL REPORTS 21 Administration 23 Buildings and Grounds 25 Development 28 Library Services 30 Public Affairs 32 RESEARCH 35 Tumor Viruses 37 Molecular Genetics of Eukaryotic Cells 93 Genetics 155 Structure and Computation 197 Neuroscience 213 CSH Laboratory Junior Fellows217 COLD SPRING -
PDF Hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/113718 Please be advised that this information was generated on 2021-10-05 and may be subject to change. BIODEGRADATION OF 1. 2. 2-TRIMETHYLPROPYI MriHYLPHOSPHONOFLUORIDATf ( SOMAN ) Studies in human and canine serum and plasma H. С J V DE BISSCHOP BIODEGRADATION OF 1, 2,2-TRIMETHYLPROPYL METHYLPHOSPHONOFLUORIDATE (SOMAN) Studies in human and canine serum and plasma BIODEGRADATION OF 1,2,2-TRIMETHYLPROPYL METHYLPHOSPHONOFLUORIDATE ( SOMAN) Studies in human and canine serum and plasma PROEFSCHRIFT ter verkrijging van de graad van doctor in de wiskunde en de natuurwetenschappen aan de Katholieke Universiteit te Nijmegen, op gezag van de Rector Magnificus Prof. Dr. J. H. G. I. Giesbers volgens besluit van het College van Decanen in het openbaar te verdedigen op woensdag 29 October 1986 des namiddags te 1. 30 uur precies door Herbert Cyr Jean Valerie DE BISSCHOP geboren te Erwetegem ( België ) GSSrt Repro 1986 Promotores : Prof. Dr. J.M. van Rossum Prof. Dr. M.G. Bogaert (Rijksuniversiteit Gent) Co-referenten : Dr. H.P. Benschop (PML-TNO) Dr. J.L. Willems (Rijksuniversiteit Gent) ISBN 90-9001415-2 The studies presented in this thesis were performed in the Department for Nuclear, Biological and Chemical Protection of the Technical Division of the Army, Vilvoorde (Belgium) and in the Heymans Institute of Pharmacology, State Uni versity of Ghent Medical School (Belgium). Figures IV-2 and V-l, previously published in "H. -
World Journal of Pharmaceutical Research Pradhan Et Al
World Journal of Pharmaceutical Research Pradhan et al. World Journal of Pharmaceutical SJIF ImpactResearch Factor 6.805 Volume 5, Issue 8, 426-443. Review Article ISSN 2277– 7105 ` BUFO SKIN-SECRETIONS ARE SOURCES OF PHARMACOLOGICALLY AND THERAPEUTICALLY SIGNIFICANT COMPOUNDS Dr. Bishnu Charan Pradhan*1 and Shakti Prasad Pradhan2 1Dept. of Zoology Angul Mahila Mahavidyalaya, Angul, Odisha, India. 759122. 2Dept. of Pharmacy. Utkal University, Vanivihar, Bhubaneswar, Odisha, India. ABSTRACT Article Received on 07 June 2016, Amphibians have been occupying a wide range of habitats since they Revised on 28 June 2016, evolved around 363 million-years-ago. Along with legs and lungs, skin Accepted on 18 July 2016 DOI: 10.20959/wjpr20168-6752 played an important role in survival of amphibians and made it possible for them to exploit diverse ecological conditions. Amphibian skin not only helps in avoiding desiccation but also helps in imposing *Corresponding Author Dr. Bishnu Charan defense against predators as well as pathogens. Amphibian skin Pradhan possesses wide variety of chemical compounds, which have potential Dept. of Zoology Angul significance in pharmacology and therapeutics. Toads especially those Mahila Mahavidyalaya, belonging to genus Bufo, are outstanding source of useful granular- Angul, Odisha, India. 759122. gland secretions. Compounds derived from toad skin-secretions can be used as analgesics, painkillers and as medicine against cardiac- problems, multi-drug resistant bacteria, HIV and Cancer. KEYWORDS: Bufadienolides, pharmacology, Bufo skin-secretions, toxins. INTRODUCTION Amphibians started trolling the landmasses of earth about 363 million-years-ago, with Acanthostega and Ichthyostega probably being the earliest of known amphibians (Evans[20] et al 1998). Fossil records elucidate that ancestors of modern amphibians like Frogs, Toads, Caecilians and Salamanders probably evolved about 200 million years ago during the Triassic period. -
Aerospace Medicine and Biology
CASE F COPY AEROSPACE MEDICINE AND BIOLOGY WITH INDEXES (Supplement 115) NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ACCESSION NUMBER RANGES Accession numbers cited in this Supplement fall within the following ranges: STAR(N-10000 Series) N73-15978—N73-17998 IAA (A-10000 Series) A73-18893—A73-21844 This bibliography was prepared by the NASA Scientific and Technical Information Facility operated for the National Aeronautics and Space Administration by I nformatics Tisco, I nc. The Administrator of the National Aeronautics and Space Administration has determined that the publication of this periodical is necessary in the transaction of the public business required by law of this Agency. Use of funds for printing this periodical has been approved by the Director of the Office of Management and Budget through July 1, 1974. NASA SP-7011 (115) AEROSPACE MEMGME AND BIOLOGY A CONTINUING BIBLIOGRAPHY WITH INDEXES (Supplement 115) A selection of annotated references to unclas- sified reports and journal articles that were introduced into the NASA scientific and tech- nical information system and announced in April 1973 in • Scientific and Technical Aerospace Reports (STAR) • International Aerospace Abstracts UAA). Scientific and Technical Information Office MAY 1973 NATIONAL AERONAUTICS AND SPACE ADMINISTRATION Washington. D.C. NASA SP-7011 and its supplements are available from the National Technical Information Service (NTIS). Ques- tions on the availability of the predecessor publications, Aerospace Medicine and Biology (Volumes I - XI) should be directed to NTIS. ...... This Supplement is available from the National Technical Information Service (NTIS), Springfield, Virginia 22151 for $3.00. For copies mailed to addresses outside the United States, add $2.50 per copy for handling and postage.