Type 2 Diabetes Mellitus in the Arumeru District of Northern
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TYPE 2 DIABETES MELLITUS IN THE ARUMERU DISTRICT OF NORTHERN TANZANIA: EVALUATION OF THE PREVALENCE AND ASSOCIATED RISK FACTORS IN RURAL COMMUNITIES By BENJAMIN JOHN MILLER A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY WASHINGTON STATE UNIVERSITY College of Nursing May 2013 © Copyright by Benjamin J Miller, 2013 All Rights Reserved © Copyright by Benjamin J Miller, 2013 All Rights Reserved ii To the Faculty of Washington State University: The members of the Committee appointed to examine the dissertation of BENJAMIN JOHN MILLER find it satisfactory and recommend it be accepted. ________________________________________ Lorna L Schumann, Ph.D., Chair ________________________________________ John Roll, Ph.D. ________________________________________ Robert Short Ph.D. ________________________________________ Cynthia Corbett, Ph.D. iii Acknowledgement I would like to thank my family for their continued support. Spending summers in Tanzania, learning about the community and culture has required patience and understanding. To my wife, thank you for everything. To my children, the times I was not home, the sacrifices you have made, helped this dream to come true. I wish to thank my committee members for the endless time spent reading and offering insight and wisdom into this dissertation. Dr. Leonard Mboera, with the National Institute for Medical Research in Dar es Salaam. Thank you for working with me these past several years. Your role as my local collaborator on this research project was invaluable. Your patience in helping me navigate the research regulations cannot really be acknowledged by words alone. During the summer of 2012, I could not have tested 709 people in Tanzania without the help of Tyler Ellis, Summer Carney, and Sarah Berg. Taking time out of your life helped me accomplish this goal. Because of your commitment and the work of the other members of our group, this project came to life. The information we collected will make a difference in the lives in this region. This could not have occurred without your help. Asante Sana! Askofu Eliud Issangya: Asante sana kwa urafiki na mchango wenu mkubwa. Ushirikiano mlionipa umewezesha kukamilisha utafiti huu katika muda uliokusudiwa. Maneno yangu hayawezi kuonesha hisia za shukrani nilizonazo kwa watu wote wa Sakila na Arumeru kwa ujumla. Shukrani zangu za kipekee ni kwa International Evangelism Centre na wafanyakazi wake wote ambao wamenisaidia kufanikisha utafiti huu. iv TYPE 2 DIABETES MELLITUS IN THE ARUMERU DISTRICT OF NORTHERN TANZANIA: EVALUATION OF THE PREVALENCE AND ASSOCIATED RISK FACTORS IN RURAL COMMUNITIES Abstract by Benjamin John Miller, Ph.D. Washington State University May 2013 Chair: Lorna L. Schumann Purpose: Describe the prevalence of diabetes in rural northern Tanzania and the association between biometric markers and lifestyle indicators with diabetes, hypertension, and obesity. Background: Diabetes in sub-Sahara Africa is expected to increase by 161% in the next 15 years. Estimates suggest the prevalence of diabetes is 4.8% in east Africa and 1.4% in rural Tanzania. The cost of health care is high when compared to average household income. Understanding prevalence rates as well as increased risk factors will help develop preventative interventions. Methods: Cross-sectional observational study was used to estimate the indirect the age-adjusted prevalence rates of pre-diabetes and diabetes in rural Tanzania. Data regarding socioeconomic status (SES), past medical history, behavioral lifestyle factors, and anthropometric measurements described the association and odds ratio for the development of impaired glucose metabolism (IGM), hypertension (HTN) and excessive adiposity. Findings: The age adjusted rates for pre-diabetes and T2DM are 2.55% (95% CI [0.06; 0.1]) and 2.81% (95% CI [0.07; 0.12]), respectively. Impaired glucose metabolism (IGM) was associated with excessive adiposity (p=.003) and hypertension (p=.001). Advancing age was significantly associated with IGM (p=.004), HTN (p=.001) and excess adiposity (p<.001). Higher glucose v levels were associated with an increased risk of developing hypertension (p=.001) and excessive adiposity (p=.006). Factors associated with excess adiposity included advancing age, female gender (p<.001) and wooden or concrete household flooring (p=.001). When regressed, higher frequency of sweet drink consumption was associated with higher fasting plasma glucose levels (p=.012). Significance: The prevalence of pre-diabetes and diabetes has been established in the rural AruMeru district Tanzania. Socioeconomic development increased the risk of developing hypertension, diabetes, and adiposity. Understanding the prevalence rates for diabetes and factors with IGM will guide in the planning intervention strategies and health policy. vi Table of Contents Acknowledgement ......................................................................................................................... iii Abstract .......................................................................................................................................... iv Table of Contents ........................................................................................................................... vi List of Tables .................................................................................................................................. x List of Figures ............................................................................................................................... xii Chapter 1 ......................................................................................................................................... 1 Background ................................................................................................................................. 2 Globalization and urbanization. .............................................................................................. 2 Type 2 diabetes mellitus. ........................................................................................................ 3 Economics. .............................................................................................................................. 5 Complications. ........................................................................................................................ 7 Tanzania ...................................................................................................................................... 7 Research Questions ................................................................................................................... 10 Specific aims. ........................................................................................................................ 10 Theoretical Model ..................................................................................................................... 10 Conclusions ............................................................................................................................... 11 Chapter 2 ....................................................................................................................................... 12 Diagnosis of Type 2 Diabetes Mellitus ..................................................................................... 14 Type 2 Diabetes in Sub-Sahara Africa and Tanzania ............................................................... 16 Diabetes in Tanzania. ............................................................................................................ 22 Type I diabetes in sub-Sahara Africa. ................................................................................... 24 Tropical diabetes. .................................................................................................................. 25 vii Risk Factors for Diabetes in Tanzania ...................................................................................... 25 Wealth. .................................................................................................................................. 27 Body Mass Index. ................................................................................................................. 28 Obesity in Sub-Sahara Africa. .............................................................................................. 29 Conclusions ............................................................................................................................... 30 Chapter 3 ....................................................................................................................................... 31 Research Design........................................................................................................................ 31 Participants ................................................................................................................................ 33 Participant recruitment. ......................................................................................................... 33 Inclusion criteria. .................................................................................................................. 34 Exclusion criteria. ................................................................................................................. 35 Human Subjects Protection. .................................................................................................