ęඈඋ1࣏ۘऺ ৰ 20 Ż ৰ 34 ƛ 20160819 ϦČ Chinese Journal of Tissue Engineering Research August 19, 2016 Vol.20, No.34
වẴ Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ[ ɏΜΟ1, ğË2 ǘ Œ1 2 এ,1 2(1ˍɞʖãîΆ½KˍɞʖDZƍ ̣˼˵Ǔď 010059Z2ˍɞʖãî Ȱij½KˍɞʖDZƍ ̣˼˵Ǔď 010059)
šϬƨɏΜΟ ğË ǘŒ এ,. ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ[J].ęඈඋ1࣏ۘऺ 2016 20(34):5155-5162. DOI: 10.3969/j.issn.2095-4344.2016.34.022 ORCID: 0000-0003-2760-2653(ɏΜΟ)
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Dz ̼௦͟⏲᪑&8சɳ҉ᱷįѥ Đǧ͔Ȍ ϛ ͏ћDiabetic foot ulcer, wound healing, dressing, treatment94 Ș^żϬՈசɳ҉Đǧ͔ȌϛĉŐωྺ3ˈωྺ3#ඹ͵̿ϛ3ᑈၠᡊ֚ିƧՈĐǧϛ 4]Ȑඈ ༞ȌĭnjᜬɴϦưĽՈĚƚ3ĭˊʐϣĭĽɳ ΞȖzͅϢ༞Ȍĭ7ZՈசɳ҉ᱷįѥ ϛ ĉŐ϶̏3̏༞சǎ͢ᜑϣĭ ጥ༞சȖzȌt༞Ȍĭ7ZՈசɳ҉ᱷįѥϛ ĉ Ő༞EΛ⁋3༞Ex⁋/༞ɳʻEΣ3༞(α ″)ି ẝϛdzƯẟசɳ҉ᱷįѥՈ͔Ȍ4͢Âሳĭȭச ɳ҉ᱷįѥՈ͏ћĉŐልሳĭ͏ћ3ᯡťêÖ3ᖊᔯћͩ4 ͟⏲᪑ ϣĭnjnjּǭɳϛசɳ҉ᱷįѥĐǧ͔Ȍ͏ћවẴ 'L᪑ ϣĭϛசɳ҉ᱷįѥඈඋ1࣏
Different wound dressings in the treatment of diabetic foot ulcers
Wang Bing-yang1, Niu Guang-ming2, Du Hua1, 2, Weng Li-xin1, 2 (1School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China; 2Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China)
ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5 1 5 5
ɏΜΟ . ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ
Wang Bing-yang, Studying Abstract for master’s degree, BACKGROUND: To date, various types of dressings have been proved to promote healing of diabetic foot School of Basic Medicine, ulcers. Inner Mongolia Medical OBJECTIVE: To introduce the principle and application of various kinds of wound dressing as well as University, Hohhot 010059, other adjuvant therapies for diabetic foot ulcers. Inner Mongolia METHODS: CNKI, PubMed, Medline and Foreign Medical Journal Full-Text Service were retrieved by Autonomous Region, computer for relevant literatures published from 2005 to 2015. The search terms were “diabetic foot ulcer, China wound healing, dressing, treatment” in Chinese and English, respectively. RESULTS AND CONCLUSION: The most commonly used dressings for diabetic foot ulcers include gels, hydrogels, sponges, foam dressings, film dressings. Polymer materials with different components exhibit their unique chemical, physical and biological properties, such as natural polymer dressings (chitin, chitosan and its derivatives, fibroin, dextran), synthetic polymer dressings (polyvinyl alcohol, polyethylene glycol/polyethylene oxide, poly(α-ester)s, all of which can promote the healing of diabetic foot ulcers. Other therapies for diabetic foot ulcers include herbal therapy, becaplermin, and maggot therapy. Subject headings: Biological Dressings; Diabetic Foot; Ulcer; Tissue Engineering
Cite this article: Wang BY, Niu GM, Du H, Weng LX. Different wound dressings in the treatment of diabetic foot ulcers. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(34):5155-5162.
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ɏΜΟ . ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ
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ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5157
ɏΜΟ . ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ
2.2.2 ^ȅ˾ƨƋǂ˥DȀĞςĝƍƟ ¬÷ _Ə[24]äǂϡæ_xu·žKóȭŀ˸ĝ ˾̚ȁ$µΣɩ9ŵKj¬÷ś̀˼8ƅƍ¬ ǫǰ˵̲ȔhKŃæˏuƹΓ¡Ũ˼Y`Ŝ˾f iſ͉ŀēȆŮ ΛͲôĝȈƨKÚ˾ âżʗˠɣͿ˒ɵÆij͇øäǂΛΓέÛ ĝùόά˼ƍƟ͇ʦƉ(jˌøh)Ϙʦ˼/ͿΓƘƍ ʦ(þŷͿΓƘ˾ʦƨ˵B˾ĝ/ʃÒ˾ʦ ƟùόάæTʼn¬÷Ȉƨ˾ʦŔƶϙhį ƨ)TʴǏΡ~EȔɡ ȩŔĝ̜ϘʦKh[24-25] ȷ§˼ξŶ˾ Ýž͇ǰ˗KäǂóŞŀ˸K9Æƙɯ` á ^ȅȆǫ˾ʦƨ2˫ŷǓĝ̼ʦŨ˼ Ý͓ȉĝóȭŀ˸ǫǰKjĉ"Ɖ<ŦǰƗǂ˼ ÛʦǓ͇KɡƤǜɺ^ȅĝɷˏ͇ƉKæÉα^ȅ| ˺ž˵̲ȔhÆȻKäǂɡΆĝƨȁ@2 â˼́Ǒh¬÷ȈƨƅaˊȌKɩȋϝþĝǒƽ ˫Şŀ˸(Ľ̀ĝ¬÷pHŴ)͇ƉKfʗˏſKɹ˼ į ǫƘɜĝį·Yɒǫǰƨĝ˾fͿDZ>Ά ĝ˰Ǔ͇˼όîĝ¬÷ȆŮĝĔ4͇ˏKäǂΛ ˾ʦ˼ʃʦKȷ͇ɒǫǰƨ(ȁˎDZ>ĝ̼ȷ ΓέÛʦˏʌξόͻ˰ʝ˼ξŶ¬÷˾Ǔ5Ć ͇˾ʦ)Ϳ˾ʦ/^ȅĝ˾ʦ˼ʃʦĝȆ˾ϡ ĦȪćſĝäǂʗTţʌ͑Ŝ2ɻ¬÷Ću æÙǾʲνƋǂ˥DȀĞςĝƍƟţʌɪƕɒ ̚ĝΓƘǧƨϡ2ʌŃ̜ƨæùόƏ͇"ˍF ǫǰƨæǜɒƍƟK̜h[16] ĈˍF˼Ə͇żˍFĝΨšȔhKÔYeΐȆŮu ȖzͅϢ༞Ȍĭ7ZՈசɳ҉ᱷįѥϛǧ> ɩĉĊĝΨšljK[26-27] ˾ʦæį·əÛʦŦʦͿűʦKȁ@uĉ"Ɖ ÆȻKäǂæÇΏfˠɣˍFͻʭÛfK˾ ͿƗǂĝ͇Ɖnƙɜį·ŦʦͿűʦȆŮKî f˼şΉ^Ί°ˠɣKÔYȆŮùŲ Ƙĝ3Ɖ͇˼͋Éĝ)̼ƶϙ˳ƅƤƙɜKhΓƘ (2)ȑʌƉžYȑʌƉžĆƕǧ>ƗǂKΟǜNj ʁǝGģKnĆȻ·Ϳ3ƕΟ·ĝ°ûƨKŃ̜ ž̼ǂǂKĆʦ̜[lŦʦjpʘBķȆŮˍF ƨĝf˵Ƌ0ɒ(Οĉ"Ɖƨ)˼u¦AD˵ʩ ȻΆƉĝƶϙfǫKjάFƀǠΙó˼̹ʗ[28-30] ĝǼ˪ÆȻKɿş͇-Kſ͇ˏϡæˏ˳ƅΓʴ ÝŻƶǠˍKȑʌƉžuǜˎʉ͇˼Ûʦ˵`͇ ǏKh>ƯKɡƤèȓŃ̜4ļKɪƕɪϊĝ̼ ÆȻKȑʌƉž͆uBʊ˼òϏǩ͇ˏKv̹ȔhK ˾f˼/ͿƅȔǒüĝ͑ȷų̓KͿ Ń̜ƨΓ ΛƋȆŮ˼ˍFȻΆƉĝŋʳȰ˼Lsˏſʲ Ƙɒǫǰƨ(Gģ˾f˾ʦ)˾Ćdžɩæ̓ĝ νKÝ̮ʠ̀˼ŋ˰̀¬÷ȈƨƏKhȑʌƉ Ͳô[17-18] ž[31-32] (1)ςäŵäǂΛΓέÛʦYςäŵĆDZ>H (3)ˠɣŵΛΓέÛʦYˠɣŵĆűʦˍF ĝƶ Ə˛ƗǂȋƗĝÛʦŭ[19-21] KáÝ̜pǠŦ ϙfǫKĆı°ȋǶȮĝu·ɒǫǰƨ9ÆK ʦ˼ςäŦʦʘǠΛŇ¹ˍF Ə@Ϧĝςäŵį ƙ Ć ƕ æ Ü Û ĝ Û ʦ ƨ K f Ħ K ` ; ·ˏ̪Kæ0Ħĝf;ĜKŃøςäŵÝɪƕ Ĝ[33-34]ÆȻKƙϡæ̋` ıLJ͈fΣɩuξÝ ϤÛʦƨKhƏűόĝʳDſ[21-22]ςäŵÝ jąĝέÛʦ ŋ_Ə^_CKƙȁ@ĆLJ̼ɡäǂĝȪć ˠɣŵΛΓέÛʦÝòΧŋ˼ȚCƏųu̜ ſKÝKϙ͇_ƏáÝ9ÆKäǂĆƕ˴͇ ˍ¹˼Ň¹CKĕƁΓ·̨όſ˗Kŋ_͇ǜ ʃʦD`Ά;njǂ˼NćD`Ά;njǂä ɒ[35-36]ÆȻKnˠɣŵæϠºƋ3ʦĝΨšljKK ǂĝ̼ʦŨ˼ÛʦǓ͇ΓȪćſ˼Γǫǰ 9 Æ ˠ ɣ ŵ ɡ Ά ĝ ƨ T R ɡ Ć Û ʦ ˵ ` ƘŰ4˵ʩäǂuæÛʦC͇Ûʦ˵`͇ ͇[37-38]ˠɣŵɦέÛʦKjςΆˠɣŵÍ@Άˠ ʕÖ°͇ʕŵÛʦ̚Ȱ͇ÖəÛʦÛʦͻ͇ ɣŵÍΆˠɣŵÍΆςΆˠɣŵÍ@Άς ΛŸͻȔh[23]ƙϡ̋` ȁˎ̼ŋCKΛnʦ Άˠɣŵ˼ÎςΆˠɣŵuşKŋ_͇KΓƘǓ ̜ɍΟ_¹ɍC ͇Kju·_άƏĝ_C͇KŹ͇̓ɡΛÛʦͻ ÆȻKäǂ`Ά˼ÍΆΆȞæ̋` ıljKƯ ͇[39-41]ˠɣŵĉέÛʦKjÒžˠɣŵÒžˠɣ ƷÛ̼)͇KøΓuɒ̼ȁh͇h`Άĝ ŵˠɣŵNjžĉKϡĆˠɣʗ́fƨÆȻKƙ ̼͑čͮÚȪćſK9ÆȋƔƖĜĖĝƨó ɜĝǫǰƘæĆƗƕƗϊĝK9Æƙɜĝŋ_̚ſ uυŦǰ͇Ɖäǂ` _CÝ˵Ƌ0ĦĝpHŴ ˼˰Ǔ͇æTŐŜŃ̜ǓļøΓKhÝΣƕϘʦ
5158 P.O. Box 10002, Shenyang 110180
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ƅά˼ɪƕÛʦƏ[40-42] æÔY͓ȉˍFùŲKùό°ĉ"^Ί˼Ϡºͷ (4)ŜŵYŜŵĉ"æÎνƏǫŦĜĖnΓ ̊́fKTţʌuŶǂ˥D¬÷˾[58-61] ƕ˲ĝÛʦ˵`͇ͻ˵`͇C͇ȴKȑΧ͇ (3)³αĉ´YlžnÝϘʦČǚ˼ȆŮɵ ˼Ùȑ͇KÝÛʦƏaěʩƿŜˠɣĆnˠ iˊȌƏu˵Ƌ0ɒĝόſ˼ĉĊĝCȁKĆɩ ɣĉ"(ŵ)̱˼ĉ"(Ŝ)ɞIƯf[43-46]Ɓ> ȋǐ̓ĝūǓȂĉŭāô°Klžuƕ˲ Ŝĉ"^ÔYɷ&ljKKĄŜĉ"æˏͮ9Û˵lj ĝ·̨Ǔ͇Cæõ͇˼ƕ˲ĝÛʦ˵`͇[51K62]K ĝ̚ˌÆȻKŜŵĉ"ˏʌŦs2͓ˍF˼fˠɣ >ƯΓόîĝħŋ͇˳ƅƤΓξÝĝKh·ž ˍFȰǢĤ˼ùŲKÔY¯ɻ˾[45-47] Ćdžɩ(αĉ)KΓϤŋ͇˼CŶſÝŋ_Ə (5);ǂY;ǂĆϤŋ͇ĝKŋ_͇ɒKÝÛ ͿÝǠˍ˵Ƌlž0ĉ[63]lžÍΆžu ʦˊȌƏɡƟ͇KæȁˎÍΆljKƷÛʪˏ̼[48]; ̋όĝÛʦ˵`͇KæõĝÛʦC͇KÆȻKƙæ ǂΛΓέÛʦuÛʦC͇KÛʦ˵`͇KÖĉ ξɵf͠Ɨ^ȅĝ́üKjǰʜâżˠɣġKʼ "ʳȰKEϟ^ÚˍFͻſ9ÆKƙĆɩƕ˲ ɬżǰlžÍΆžərhEGFTţʌǜɒfˠ ĝ˾ʦKhƟKhKjʘŇ͓˼͓˗˾˼ ɣˍFĝÛAȁ[58K61] Ϙʦ¦ĶƙuŶΨšˍF_vKÔYͻʭÛfˍ ΥˍĉĆdžɩuÛʦ˵`͇˼æÛʦ Fε Ė¬÷ǂā;ǂ˾ʦTKhǂ CĝĉKnƙæÔY¬÷ɯĉ˾EϠºΨšlj ˥D͉ŀbĞςͿ¬÷ɃAƏ[49] KKThȆŮÜÛ˼¬÷˾ǒɻĝΡ~Υ ȖzȌt༞Ȍĭ7ZՈசɳ҉ᱷįѥϛ* ˍĉCŶȁ0lž ·ž˼lžÍΆ (1)ʾ·Yʾ·ĆuϤŋ͇ʕŵʕ žʌ˩͇ȴ[58-59] ƁXKl·CŋC`CĜĖĝÒžʾĉÛʦ˵ 2.3 =Ǫ [͞|ġì˼ċŪȽą ˫8ƅKŌƋǂ `͇ĝ˾ʦ[50-53] ʾ·TʴǏhȆŮɵ ˥DȀĞςĝƍƟǒƽuÖ¹ϘʦÛA9ǰ¦Ȍ i˼ϘʦģŪKƤƙĝɒϤŋ͇˼ʳŋˏſKƙ͆ ϘʦțƹƟƽΛ¯÷ȈƨĝKhġǂ˥DȀAΉ æTƅȔfâżˠɣǙŮͦ˒ɵġ́üÆ Ğς˼ΠƗɃAĆĕƁ͂9ŪĝƗϙ°99ÆK ȻKƙuƕ˲ĝ̼˼ɍ͇ˏKΛƕ˲ĝ̚Ȱ͇ ¬÷̱ŨÖÛŵøhƋ¬÷˾˼ȆŮ͑ȧϡΖɡ ˏ˼φÙȑ>ƯKʾ·2˫̜^Ŷĝ·̨ ƗϙKÖ¹άĝͲô̋îiſ°$µəÛʦĝļ ͇ˏ(jόſ˼Ĉ͇)Λ˵Ƌ0-ĝKɿş͇ʾ Ʋͯʑ˼ɃAΠƗiſ ·̋` _CK9Æ^æˏĆɩAΉͿe͇Ȉ uãνΡ~2ʌKį·¦Ȍ Ϙĝǧ>˾f ƨʾ·ΛΓέÛʦThȔ@ʷ¬÷ȈƨKE 9ʦijΡLˊȌűʦƏáÝĝɪƕÛʑɣs Ƌǂ˥D¯ɻƍƟY̓Ƥ!ē[54]ÆŭȻK fǫKæhʦ̜ɃA͇ΝD˼ȴ͇¬÷ĝƍƟ ʾ·ɡΆĝȈƨ͆TξÛuÛʦͻ͇ĝ̼˾ʦK ampucareĆƏ ϘfǫKΓͻ͇fǫƶϙĆF˼ jîɎŵ˼̈́@̺Ö¹Ϙʦĝu̚ČǚKæˏu ͓KijƕrΆϘʦKhbƍƟ¶¬¯ɻ ƹȷ§AΉ˄˾ĝEƷš ¯ɻġKuÖΨ˼Ö¹͇ˏKȅðϡǜɒƤ¯ɻͻ (2)Ƶ·«̈́φɂYƵ·Ćƕɦ ǐƘKuƃǢȆŮÜÛΟĖɷ&Ő;Ȕhĝɷˏ] ϡTcɡ̈́φɂͿφ̼ʾKŃ$µƙĝǫ Å΄ŐʌĆƕhbƍƟǂ˥D˗ŪĞς(& ǰƉƘƙuϤŋ͇Ûʦ˵`͇Ĉ͇ʕŵ͇ &Ļ˼ȡ)ϘʦKijͻ̔0·͇ÛA9ǰśϘʦK ˼ǜɷ&°͇ĝʦƉKÖĉ"ʳȰKEϟæȁˎ<Ŧ æÔYˍFĝǫƪ˼̵ĝ͓ȉĝ́fȁˎîIJǂ˥ ǰͿυŦǰ˾ljK˾f̈́φɂ[55]Ƶ·͆æ Dʖ̀ēκ2ʌKampucareƍƟȆ0]Å΄Őʌƍ ΓƘ˾ʦʃKjäǂlž·ž˼ ƟȆÝÝǂ˥Dʖ̀îIJĝ¬÷˾Əĝɷ̚ɯ ȮȤžKǜɒΓʝuĝ_CſϣóK͇ˏ ˲[20] ſ͇ˏΛBfſ˼̚ſΆƵ·σƅʃʦ Ɨ̃Ρ~QęæøhțƹƟƽȷ§ǂ˥DȀ ĝ́fϡĆɩæ̓ĝͲô Ğς¬÷ɃA˾ēŃ̜țƹæèGģȭΊ¬ ΆƵ·ĝŋ˰Th͠ƗÛʦ ÷ƍƟ[7]ƗȆżˍFΚțÇΏ9ǰˊȌ͇ɒΊφƟ ƏKGģ¬÷Ȉƨ[56-57]ÆȻK9ɡŃƕś̀ĝŋ˰ ƽ|( )Ɵƽ˼ǹɰĝøh[30K33]
ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5159
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3ʉƗProspects 4 džDz References ǂ˥DȀĞςĆǂ˥Dĝ@ϦEƷšKæˏͮ [1] International Diabetes Federation e-atlas of diabetes. 5th ed.,http://www.idf.org/diabetesatlas;2011 ĕƁΠƗ˼sͫɃAKÝΖƂĝē˗ĕƁ9Ū [accessed October2012]. ƍƟȁ@GģÖ¹ϘʦÛA9ǰ¦ȌϘʦț [2] Wang SY,Wang JN,Lv DC,et al.Clinical research on the ƹƟƽ˼ȈƨĝøhKŻÝǜɒǂ˥DȀĞς͉ŀ bio-debridementeffectof maggot therapy for treatment ĝÛͻƉƘKϠǖȍǂ˥DȀĞςƍƟŰĆ of chronically infected lesions.Orthop Surg. 2010;2(3): Ρ~ŀ˼ƲÛĝɩǯĞ 201-206. [3] Krishnan S,Nash F,Baker N,et al.Reduction in diabetic Ũ̀ĝȈƨKȶȦŋǫͬ̑Kĉ"ɍǷáK amputations over 11 years in a defined UK population: ÛA9ǰÇΏÖ¹ͻ͇φÙȑȁ˼uˏſÔY benefits of multidisciplinary work and continuous DZ_ĝ ¯KÔYeΐȆŮĝÛ9˼ȆŮ˾ˎi. prospective audit.Diabetes Care. 2008;31: 99e101. ÆȻKƙKȶuAΉ͇̚ȁɒϘʦsͫČǚ [4] Vamos EP,Bottle A,Edmonds ME,et al.Changes in incidence of lower extremity amputations in individuals ʲνKǡõ¦ȌȈƨĝ̵̀ȈƨÇƷKΓƏGģ with and without diabetes in England between 2004 ˾^ȅĝ˾ʦ˼øhɯɒ̚ĝ ƃǒƽ¯ ȷ and 2008. Diabetes Care.2010;33:2592e7. YƨKLţȋjĝ¬÷̈́rÆȻKϘhȈƨ [5] Blackman E,Moore C,Hyatt J,et al.Topicalwound lȔɡu̚ĕƅįƍƟ˼ȷ§ǂ˥DȀĞς ˛ oxygen therapy in the treatment of severediabetic foot uÖ¹ŵ/ÖÛŵ(ϠºɃA)Kͻ̔0·ʦƉK͉ŀ ulcers: a prospective controlled study.Ostomy Wound Manage. 2010;56(6):24-31. DZÎĝȼˍFÛA9ǰ˼ƗŤįͬ̑(ȁˎÛA9 [6] Schaper NC,Andros G,Apelqvist J,et al.Specific ǰ˼ˍF9ǰĝ°Ő˼˗Őĝ͵͇͂ĝĉ"ŋCȔ guidelines for the diagnosis and treatment of peripheral h)ĝȴ͇Ψš¬÷Û̼·ƅ˼ȷ§ƍƟ̜Ρ~ arterial disease in a patient with dia-betes and Ʒ˫ǧ>ǜ$ʦÝƍƟǂ˥DȀĞς˩ýîĝ ulceration of the foot, 2011. Diabetes Metab Res Rev. ξſ>ƯKŃ̜Ʒ˫E^õ2ôεĝͲôK9ɡ 2012;28:236e7. [7] Gimenez M,Lopez JJ,Castell C,et al.Hypoglycaemia Ń̜̼˾ʦĝKhɒɒǜ@˄K˄Ő;Ϳõƅ and cardiovascular disease in Type 1 Diabetes. 9ÆKÝ^ĝ įΡƷɯɒ̚˼ɯĦφĝÛʦ˵ Results from the Catalan National Public Health `͇˼ÛʦæChȈƨ şͮaěʩƿK ƙ registry on insulin pump therapy. Diabetes Res Clin ɜhǂ˥DȀĞς¬÷bɲKȷ§͉ŀ̱Ũ˼ Pract.2012;96:e23-25. [8] Mohammedi K, Maimaitiming S, Emery N, ÛͻƉƘ Bellili-Munõz N, Roussel R,Fumeron F, et al. Allelic
variations in superoxide dismutase-1 (SOD1) gene are ň້ᯥDzȈĹň້dž^তՈ᪂ᩥ3ǒ9ʐ᪈Ĝ associated with increased risk of diabetic nephropathy Ởᩳň້ūȰtǕʝÂȴϦ'ᡅǚΝ͛ᢅ4% in type 1 diabetic subjects. Mol Genet Metab 2011; .֎Ξॅ¤ƅň້͝Ȑᩨdzত\ּ͟-֎Ξॅ4% 104:654-660- [9] Chan SY,Wong KL,Lim JX,et al.The role of Ēˊ⒲LƦ5ǎĒˊΞॅͱǭ4% Renasys-GO in the treatment of diabetic lower limb তɡₑতϦČQ>ඓẋ CNKI ǑेDz̼ϟ ulcers: a case series.Diabet Foot Ankle. 2014;524718. ிඣẟᜐ 3 Ƶɡₑ4 [10] Skórkowska-Telichowska K,Kulma A,Szopa J.The .ত̲ǕতඓęͱɃȐᜐ̲ǕcǪǐֶ̲Ǖ ৪ response of diabetic foot to a new type of dressing International Archives of Medicine.2012;5:33. ȌƨǕःNjd4% [11] Whiting DR,Guariguata L,Weil C,et al.IDF Diabetes ň້̌ৰPň້ȭzۘऺʐ̔΅ՈϦɴՈ Atlas: global estimates of the prevalence of diabetes ]ᜐ&ãĩᯧç45ǎՈƣϧĚċ3ϔǒrĉŐᩥ for 2011 and 2030. Diabetes Res Clin Pract.2011;84: ਜ਼ƶϔǒßxᩴơǎʳƨ>ŭ+ƅ͟ᢈǎljƌ3 ʐ⏄ 311-321. ɕ dzȉǛʴɡ4% [12] Westphal C,Neame IM,Harrison JC,et al.Adiabetic footulcer pilot study: does silicone gel sheeting reduce তČƿতϦČQƾȣ>^͔Ŀň້Ǭƿ¦ੂึ the incidence of reulceration?J Am Podiatr Med Assoc. rČƿּ͟œᩲ4% 2011;101(2):116-123.
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[13] Dumville JC,Deshpande S,O’Meara S,et al. [26] Wilgus TA. Immune cells in the healing skin wound: Hydrocolloid dressings for healing diabetic foot ulcers. influential players at each stage of repair.Pharmacol Cochrane Database Syst Rev. 2012;2: CD009099. Res.2008;58:112-116. [14] Motzkau M,Tautenhahn J,Lehnert H,et al.Expression of [27] Schreml S,Szeimies R,Prantl L,et al.Wound healing in matrix-metalloproteases in the fluid of chronicdiabetic 21st century.J Am Acad Dermatol. 2010;63:866-881. footwoundstreated with a protease absorbent [28] Rodero MP,Khosrotehrani K.Skin wound healing dressing.Exp Clin Endocrinol Diabetes. 2011;119(5): modulation by macrophages.Int J Clin Exp Pathol. 286-290. 2010;3:643-653. [15] Kim BY,Kim CH,Jung CH,et al.Association between [29] Tellechea A,Leal E,Veves A,et al.Inflammatory and subclinical hypothyroidism and severe diabetic angiogenic abnormalities in diabetic wound healing: retinopathy in Korean patients with type 2 diabetes. role of neuropeptides and therapeutic perspectives. Endocr J. 2011;58:1065-1070. Open Circ Vasc J.2009;3:43-55. [16] Lozeron P,Mantsounga CS,Broqueres-You D,et al. [30] Ulrich D,Smeets R,Unglaub F,et al.Effect of oxidized Characterization of nerve and microvessel damage regenerated cellulose/collagen matrix on proteases in and recovery in type 1 diabetic mice afterpermanent wound exudate of patients with diabetic foot ulcers. femoral artery ligation.J Neurosci Res. 2015;93(9): J Wound Ostomy Continence Nurs. 2011;38(5): 1451-1461. 522-528. [17] Li H,Cao C,Huang A,et al.Comment on "Topically [31] Scott Causby R,Pod M,Jones S.Dressing plantar Applied Connective Tissue Growth Factor/CCN2 wounds with foam dressings, is it too much pressure? Improves Diabetic Preclinical Cutaneous Wound Diabet Foot Ankle. 2011;2:10.3402/dfa.v2i0.8751. Healing: Potential Role for CTGF in Human Diabetic [32] Chen H,Zheng Z,Huang Y,et al.Amicroalbuminuria Foot Ulcer Healing".J Diabetes Res. 2015;2015: threshold to predict the risk for the development of 512959. diabetic retinopathy in type 2 diabetes mellitus patients. [18] Imran M,Hussain MB,Baig M.A Randomized, PLoS ONE. 2012;7:e36718. Controlled Clinical Trial of Honey-Impregnated [33] Prevention CfDCa.National Diabetes Fact Sheet: Dressingfor TreatingDiabetic Foot Ulcer.J Coll National estimates and general information on Physicians Surg Pak.2015;25(10):72172-71275. d ia b e te s a n d p re d ia b e t e s in th e U n it e d S ta t e s , 2 0 1 1 . In : [19] Vehik K,Dabelea D.The changing epidemiology of type Services USDoHaH, editor. Atlanta, GA: 1 diabetes: why is it going through the roof? Diabetes U.S.Department of Health and Human Services; Metab Res Rev.2011;27:3-13. 2011:1-12. [20] Hasan MY,Teo R,Nather A.Negative-pressure wound [34] Lepantalo M,Apelqvist J,Setacci C,et al.Management therapy for management of diabetic foot wounds: a of critical limb ischaemia and diabetic foot. Clinical review of the mechanism of action, clinical applications, practice guidelines of the European Society for and recent developments.Diabet Foot Ankle. 2015; Vascular Surgery. Eur J Vasc Endovasc Surg.2011; 6:10.3402/dfa.v6.27618. 42:S60e74. [21] Patil V,Patil R,Kariholu PL,et al.Topical Phenytoin [35] Zoher K,Kolli ME,Riahi F,et al.Preparation and Application in Grade I and II Diabetic Foot Ulcers: A characterization of hydrocolloid biopolymer-based films Prospective Study.J Clin Diagn Res. 2013;7(10): for dressings application.Int J Polym Mater. 2009;58: 2238-2240. 665-680. [22] McCance DR. Pregnancy and diabetes. Best Pract [36] Dai T,Tanaka M,Huang YY,et al.Chitosan preparations Res Clin Endocrinol Metab 2011;25:945-958. for wounds and burns: antimicrobial and [23] Mendes JJ,Marques-Costa A,Vilela C,et al.Clinical and wound-healing effects. Expert Rev Anti Infect Ther. bacteriological survey of diabetic foot infections in 2011;9:857-879. Lisbon.Diabetes Res Clin Pract. 2012;95:153-161. [37] Khoushab F,Yamabhai M.Chitin research revisited.Mar [24] Zubair M,Malik A,Ahmad J.Clinico-microbiological Drugs.2010;8:1988-2012. study and antimicrobial drug resistance profile of [38] Madihally SV.Processing chitosan for tissue diabetic foot infections in North India.Foot(Edinb). regeneration. Curr Trends Polym Sci. 2011;15:83-88. 2011;21:6-14. [39] Galeano M,Polito F,Bitto A,et al.Systemic [25] Silva L,Carvalho E,Cruz MT.Role of neuropeptides in administration of high-molecular weight hyaluronan skin inflammation and its involvement in diabetic wound stimulates wound healing in genetically diabetic mice. healing.Expert Opin Biol Ther. 2010;10:1427-1439. Biochim Biophys Acta. 2011;1812:752-759.
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