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Different Wound Dressings in the Treatment of Diabetic Foot Ulcers

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Different Wound Dressings in the Treatment of Diabetic Foot Ulcers ęඈඋ1࣏ۘऺ ৰ 20 Ż ৰ 34 ƛ 20160819 ϦČ Chinese Journal of Tissue Engineering Research August 19, 2016 Vol.20, No.34 වẴ Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ[ ɏΜΟ1, ğË2 ǘ Œ1 2 ຅এ,1 2(1ˍɞʖãî͸Ά͸½KˍɞʖDZƍ̣˼˵Ǔď 010059Z2ˍɞʖãî͸ Ȱij½KˍɞʖDZƍ̣˼˵Ǔď 010059) šϬƨɏΜΟ ğË ǘŒ ຅এ,. ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ[J].ęඈඋ1࣏ۘऺ 2016 20(34):5155-5162. DOI: 10.3969/j.issn.2095-4344.2016.34.022 ORCID: 0000-0003-2760-2653(ɏΜΟ) তȷợⓉᪿ Ɏ>τK˿K1992 ˝ÛK ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈàϬ ̂Zà ͟˭NK˩ȂK ˍɞʖãî͸ÝŸœ ͅϢ༞Ȍĭ ϶̏௤3̏༞சǎ͢ᜑϣĭ3ồᯬ‼3൨ම௤ ǎ͢ᜑϣĭ3 ௤3ጥ༞ச þKƶϙÎāDŨ͸Dž Ϥ$ ச ɳ ҉ ᱷ į Ě ିǻ:R318 ѥ͔Ȍϛ A:ۅDzʃ᪊ তේǻ:2095-4344 ༞EΛ⁋3༞Ex⁋/༞ɳʻEΣ3༞(α″) Ȍt༞Ȍĭ (2016)34-05155-08 ɘ4ěY2016-05-22 L₎5 Đǧϛ ƅ࿁ȴƇīRɳʟ ẟᜐʨĿdž ࿁̻z­ǶϦĐǧÃ^ʐȟɬ±┨ Ưẟඈඋₑ à᪩ljĈĐǧණǕͫɏ ͣƅû ņẋ࣏ à᪩ͣƅϣĭּǭɳ ]š᰻çŁẋγz̹ѯàਘǑà ነ3û̺ňϬà᪩ǔǭ$┨໐]ỤtĐǧĐ Ñ-z,ϣඈඋϣt4 ˊ̿Ոǧϛà᪩ᰏtˈ ¿ᜥ ᖏՁ›ȵƌ ϣ⑃üƄ>ɬ3ûነϏɳ3ʻÃồɋʐƅ࿁Ư ẟႮŢՈ± ƯẟཌྷᆁඈඋՈϣʐඈඋ͔Ȍẋ࣏4Ǹ̲ Ʒà᪩ͣƅ⑃ƛɳ3άɋʌ3ሳĭťන₎ ņ΢4ֲQ ŻÏČඣϛՈ,Ƨϛ>ŌǕ ͢ĉŐ£Ȍ]ȐՈ༞ȌĭʐūϬŰʌάՈ༘5ͩ Νẟnj lj᪅żĄՈĐǧɳʟ4 ʼᡅ ëۘऺ>᪅ ]ȐnjϛdzƯẟசɳ҉ᱷįѥՈ͔Ȍ4ྐ Ո·එȈ࢑ିƧϛՈƣˊʐàϬ Ñǎ͢Âȭசɳ҉ᱷįѥՈṉ­ћͩ4ֲ 5ͩàϬᩥਜ਼ƶ̼௦ CNKI3PubMed3Medline3ᡃϣĭĿƚƛDzϔǒß 2005 Ⴗ 2015 ÀՈ Dz ̼௦͟⏲᪑&8சɳ҉ᱷįѥ Đǧ͔Ȍ ϛ ͏ћDiabetic foot ulcer, wound healing, dressing, treatment94 ඗Ș^඗᩾żϬՈசɳ҉Đǧ͔ȌϛĉŐωྺ3ˈωྺ3#ඹ͵̿ϛ3ᑈၠᡊ֚ିƧՈĐǧϛ 4]Ȑඈ ༞ȌĭnjᜬɴϦưĽՈĚƚ3ĭˊʐϣĭĽɳ ΞȖzͅϢ༞Ȍĭ7ZՈசɳ҉ᱷįѥ ϛ ĉŐ϶̏௤3̏༞சǎ͢ᜑϣĭ ௤ ጥ༞சȖzȌt༞Ȍĭ7ZՈசɳ҉ᱷįѥϛ ĉ Ő༞EΛ⁋3༞Ex⁋/༞ɳʻEΣ3༞(α″)ି ẝϛdzƯẟசɳ҉ᱷįѥՈ͔Ȍ4͢Âሳĭȭச ɳ҉ᱷįѥՈ͏ћĉŐልሳĭ͏ћ3ᯡťêÖ3ᖊᔯћͩ਍4 ͟⏲᪑ ϣĭnjnjּǭɳϛசɳ҉ᱷįѥĐǧ͔Ȍ͏ћවẴ 'L᪑ ϣĭϛசɳ҉ᱷįѥඈඋ1࣏ Different wound dressings in the treatment of diabetic foot ulcers Wang Bing-yang1, Niu Guang-ming2, Du Hua1, 2, Weng Li-xin1, 2 (1School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China; 2Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China) ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5 1 5 5 ɏΜΟ ਍. ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ Wang Bing-yang, Studying Abstract for master’s degree, BACKGROUND: To date, various types of dressings have been proved to promote healing of diabetic foot School of Basic Medicine, ulcers. Inner Mongolia Medical OBJECTIVE: To introduce the principle and application of various kinds of wound dressing as well as University, Hohhot 010059, other adjuvant therapies for diabetic foot ulcers. Inner Mongolia METHODS: CNKI, PubMed, Medline and Foreign Medical Journal Full-Text Service were retrieved by Autonomous Region, computer for relevant literatures published from 2005 to 2015. The search terms were “diabetic foot ulcer, China wound healing, dressing, treatment” in Chinese and English, respectively. RESULTS AND CONCLUSION: The most commonly used dressings for diabetic foot ulcers include gels, hydrogels, sponges, foam dressings, film dressings. Polymer materials with different components exhibit their unique chemical, physical and biological properties, such as natural polymer dressings (chitin, chitosan and its derivatives, fibroin, dextran), synthetic polymer dressings (polyvinyl alcohol, polyethylene glycol/polyethylene oxide, poly(α-ester)s, all of which can promote the healing of diabetic foot ulcers. Other therapies for diabetic foot ulcers include herbal therapy, becaplermin, and maggot therapy. Subject headings: Biological Dressings; Diabetic Foot; Ulcer; Tissue Engineering Cite this article: Wang BY, Niu GM, Du H, Weng LX. Different wound dressings in the treatment of diabetic foot ulcers. 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Box 10002, Shenyang 110180 ɏΜΟ ਍. ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ ˰ͻ9ǰTČǚKĕƁÝƍ¬bɲĝˠɣĉ"˰Ć^ Ćŋ˼φΧĝ6ȑʗ>ƯKŋǠȈƨĝKhÝό Ίˠɣĉ"˰ĆȔɡɩƲðŔKEÉƂɡƃ̢ ƫĝɃA¬÷ŰTƉKæˏn4φ˼ˎſNé ĝ˾8ƅ ĝ̈́rKæξό͂ŝȆŮĝDZʉǫCK9Æͮݬ÷ ǂ˥DĆƕũƗƕBķȆŮ3@uʩĝΝ ¡ùξɃAĝǼ˪˰ȁ@Kh́fâż˼°͓ DKŃ̜3@^Ŷǂ˥D͉ŀ¬÷˾K`ʭuȀ ́fĝ¬÷K9ÆƘɜϡæh͂¬÷KŶÔY ʌ˼ĉĊĝʭŨKǂ˥DȀĞς¯ɻ͆Ć˾͇ȴͿ ¬÷ ¯Ń̜ƨæͬ¸LsÝǂ˥DȀĞς¬÷ ʕƽ˾ Iˎ1ƛ[12-13] 2.2 ŧϐϘϘ$ƙ͞|ġì˼ċȿŤ jΜ͇¬÷ ˈωྺYŃśȈƨƶϙĆhɣ̱ɒſNéĝ¬ ϊKùόǂ˥DȀĞς˾ĝˎil ŻK¬÷ ÷̈́rKþͿ͹˾ŋ˾˾ʦ(j˰ĝ́ü)ÝL ȈƨKȶͲôĉĊĝÛʦƨKǕŸɃAKÔY ǍŋǒɻǜÞ20%jˌŋ˛Ƙɒ95%KŃ̜ƨ ˾(ǜɺɩŨ̀ĝév̈́rK:ƹ¬÷ʩ)KÝƍ ȁ@ŷşɡɒʳŋ͇Ķūŋ˰æʃφͿǜʃφ ƟˎiƏKϘhțƨæǜɺsͫ˼u̚ĝÛʦͻ͇ʦ ƃKõƅ^Ɔ̓Įĝˏſ˼ɣ̱Γʊ̈BʊKƯ ƉČǚKǕŸΓݬ÷˾ˎiƏΉŶȤ̼ǂ˥D ϟƘɜæˏæ˙Ĥî(Ϳƒ̔)Ýŋ̈́rƏǓşĝ ȀĞςÝ͸°æƗƕǒüǫśKĄƖuĝǫśų pHŴ˼ŦǰόſŴŋ˰ˏʌÔY ¯ĝ͂ŝȆ ĞςÏſ˼ĆȆáÝʘƅΨͿ͂ɡ/Ǚ ŮDZ_Kɯu̚ıȼò¬÷K̋ºuÙ[12-13]Ń 2.2.1 ¬÷ȈƨĝƕśΛƶϙǓļ DZ>͓ȉTR ś¬÷ȈƨĝîjļĆKƘɜȁ@æ0˲ıKh ɡĆɃɕĝ¬÷ȈƨK9ÆŨ̀ĝ¬÷ȈƨKȶēǢ ˼KɐuΖîȼH¬÷­>Ưŋ˰ȈƨĝK ȧƅƙĝij͇Îŵö°ÑK¬÷ȈƨȋTRɡÝ hiͥݬ÷ǫɯʦˎƗðKͮĕƁ¬÷_Dz˼ʕƽ ˾ˎiƏźĆΟƕTŦḺȔh>ƯK]Σí ˾ʁǝ ˝įƷ˫évȈƨæÔY¬÷ɯĉı˾ÆȻK #ඹ͵̿ϛYÆśȈƨKhÝɹ˼Ϳɒ̐˳ĝ Néĝ¬÷̈́rϡĆɩzĕfˠɣˍF˼(Ɖˍ ¬÷KƘɜ.İøhǓşĝ˾ʦƨ˼̮ʠ FùŲ˼ε Λùό°ĉ"˾fĝƗϙ9ŵKϠº ̠ſįʳĔ¬÷ǠŃ̜ȈƨĆɒſʳĔάKu ͷ̊́f ͇ḺȔhKȐ˾ÎǠ͓ȉ2ɻÆȻKƘɜ̋` ƤLţȋμĝŋǫƋ¬÷̈́rKʲν¬÷Ȉ TǺKæĉKƖ͛¬÷ĝî̔[14]9ΓʳĔ͇˼ ƨϡKȶY uˏſǜɺév̈́rKY̓ΧǠ͈K Ǖ̱ǓļK̮ʠüȈƨæǍݬ÷Aê7 d9ÆK ˏʌ:ƹ̖¬÷Ù˼ː KÔYȆŮƗ ˎ ̮ʠTǜȔɡǂ˥DȀĞςƍƟĝξÝ̡ͲȈ iZ!KȶuÛʦ˵`͇K^DΟQ˽ˎʉͿɷ& ƨ[15] KëljKZ"KȶḺ¬÷ηƷɃAKuÖ¹Ö ᑈၠᡊ֚ିƧՈĐǧϛYŃśȈƨȁ@Ćȑʌ ΨȔhZ#Kȶ̋`Ư^ïf¬÷¯¬KŶ ĝKˀhK`ȔKφɤ(KæɺîƙøhZȑ ̵ÛȆŮÛfĄn¬÷ĝ^ȅś̀˼¬÷˾ φ˼ŋŕΧK@@^ȑŋ˼ˍ¹KˏʌǕŸˍ¹ʒAZ 8ƅĝ^ȅKʲνW>ɐuƕȈƨæu̚KhƖ ij̚άJʗȈƨĝƶϙ4ļĆKƘɜKȶźh u¬÷ɡƤȱȀîƗļ¬÷˾ĝ͛˼˾ĝ^ ̋ºuǫɯʦĝ¬÷Kȁ@æsͫKhšʜǧ ȅ8ƅKlÇƷƤ^ȅĝ¬÷Ȉƨĉh^ȅ¬÷ nJʗȈƨæɯ˲ı͑ȧ¬÷­KEuȷ§ǐ ś̀[10] ǠͰİĝij͇K9ÆJʗȈƨϡŰÝÇƷ˼Kh ɬƙɜĝƶϙś̀˼ǓļKȋ@hĝǂ˥D¬ ǂ˥DȀĞςƍƟ[1] ÷˾Ȉƨƨæǫśj˗Y ^ȅĝÛʦ˾f˵`͇ƨ˼ǧ>ɒǫǰ̼˾ ωྺYŃśĆNé·ƅĝ¬÷ȈƨKȁ@Gģ ʦKΛƙɜĝ͹˾ʦͿȆ˾˼^ȅĝ¡ŨǒƽK ɩŦsƨ(j6ȑJʗ̮ʠͿĉˠɣʕǙ_)˼ TǜE!şǠȻ˼Ǡˍ¬÷ȈƨĝKhŃ̜Ȉƨ "Ϥŋ/ǠżǰKæˏ˛uÛʦ˵`͇ĝ˰ĝ ƨ­hKEÝƲ­°øhɡ\˼ξό. ĉ"Ɖ(j°ʌ)ͿƗǂ(jˠɣŵΛΓέÛ ¬÷ȈƨɷˏKÇƷƤΣƕ^ȅĝȋKjÇΛĝÛ ʦ)[11]Ċ4 ¬÷ÙʦðKŃ̜ƨ ʳĔ¬÷ ʦͻ͇̼˾ʦ(jÛA9ǰŤ˾fϘʦ˼/ͿDZ> ǠK9Ææ¯ ɩNéĝ̈́rÆȻKƙɜϡ Ά̼˾ʦ/ǜ$)ĝϘhțƨ ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5157 ɏΜΟ ਍. ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ 2.2.2 ^ȅ˾ƨƋǂ˥DȀĞςĝƍƟ ¬÷ _Ə[24]äǂϡæ_xu·žKóȭŀ˸ĝ ˾̚ȁ$µΣɩ9ŵKj¬÷ś̀˼8ƅƍ¬ ǫǰ˵̲ȔhKŃæˏuƹΓ¡Ũ˼Y`Ŝ˾f iſ͉ŀēȆŮ ΛͲôĝȈƨKÚ˾ âżʗˠɣͿ˒ɵÆij͇øäǂΛΓέÛ ĝùόά˼ƍƟ͇ʦƉ(jˌøh)Ϙʦ˼/ͿΓƘƍ ʦ(þŷͿΓƘ˾ʦƨ˵B˾ĝ/ʃÒ˾ʦ ƟùόάæTʼn¬÷Ȉƨ˾ʦŔƶϙhį ƨ)TʴǏΡ~EȔɡȩŔĝ̜ϘʦKh[24-25] ȷ§˼ξŶ˾ Ýž͇ǰ˗KäǂóŞŀ˸K9Æƙɯ`á ^ȅȆǫ˾ʦƨ2˫ŷǓĝ̼͸ʦŨ˼ Ý͓ȉĝóȭŀ˸ǫǰKjĉ"Ɖ<ŦǰƗǂ˼ ÛʦǓ͇KɡƤǜɺ^ȅĝɷˏ͇ƉKæÉα^ȅ| ˺ž˵̲ȔhÆȻKäǂɡΆĝƨȁ@2 â˼́Ǒh¬÷ȈƨƅaˊȌKɩȋϝþĝǒƽ ˫Şŀ˸(Ľ̀ĝ¬÷pHŴ)͇ƉKfʗˏſKɹ˼ įǫƘɜĝį·Yɒǫǰƨĝ˾fͿDZ>Ά ĝ˰Ǔ͇˼όîĝ¬÷ȆŮĝĔ4͇ˏKäǂΛ ˾ʦ˼ʃʦKȷ͇ɒǫǰƨ(ȁˎDZ>ĝ̼͸ȷ ΓέÛʦˏʌξόͻ˰ʝ˼ξŶ¬÷˾Ǔ5Ć ͇˾ʦ)Ϳ͹˾ʦ/^ȅĝ˾ʦ˼ʃʦĝȆ˾ϡ ĦȪćſĝäǂʗTţʌ͑Ŝ2ɻ¬÷Ću æÙǾʲνƋǂ˥DȀĞςĝƍƟţʌɪƕɒ ̚ĝΓƘǧƨϡ2ʌŃ̜ƨæùόƏ͇"ˍF ǫǰƨæǜɒƍƟK̜­h[16] ĈˍF˼Ə͇żˍFĝΨšȔhKÔYeΐȆŮu ȖzͅϢ༞Ȍĭ7ZՈசɳ҉ᱷįѥϛǧ> ɩĉĊĝΨšljK[26-27] ˾ʦæį·əÛʦŦʦͿűʦKȁ@uĉ"Ɖ ÆȻKäǂæÇΏfˠɣˍFͻʭÛfK˾ ͿƗǂĝ͇Ɖnƙɜį·ŦʦͿűʦȆŮKî f˼şΉ^Ί°ˠɣKÔYȆŮùŲ Ƙĝ3Ɖ͇˼͋Éĝ)̼ƶϙ˳ƅƤƙɜKhΓƘ (2)ȑʌƉžYȑʌƉžĆƕǧ>ƗǂKΟǜNj ʁǝGģKnĆȻ·Ϳ3ƕΟ·ĝ°ûƨKŃ̜ ž̼ǂǂKĆʦ̜[lŦʦjpʘBķȆŮˍF ƨĝf˵Ƌ0ɒ(Οĉ"Ɖƨ)˼u¦AD˵ʩ ȻΆƉĝƶϙfǫKjάFƀǠΙó˼̹ʗ[28-30] ĝǼ˪ÆȻKɿş͇-Kſ͸͇ˏϡæˏ˳ƅΓʴ ÝŻƶǠˍKȑʌƉžuǜˎʉ͇˼Ûʦ˵`͇ ǏKh>ƯKɡƤèȓŃ̜4ļKɪƕɪϊĝ̼͸ ÆȻKȑʌƉž͆uBʊ˼òϏǩ͇ˏKv̹ȔhK ˾f˼/ͿƅȔǒüĝ͑ȷų̓KͿ Ń̜ƨΓ ΛƋȆŮ˼ˍFȻΆƉĝŋʳȰ˼Lsˏſʲ Ƙɒǫǰƨ(Gģ˾f˾ʦ)͹˾Ćdžɩæ̓ĝ νKÝ̮ʠ̀˼ŋ˰̀¬÷ȈƨƏKhȑʌƉ Ͳô[17-18] ž[31-32] (1)ςäŵäǂΛΓέÛʦYςäŵĆDZ>H (3)ˠɣŵΛΓέÛʦYˠɣŵĆűʦˍFĝƶ Ə˛ƗǂȋƗĝÛʦŭ[19-21] KáÝ̜pǠŦ ϙfǫKĆı°ȋǶȮĝu·ɒǫǰƨ9ÆK ʦ˼ςäŦʦʘǠΛŇ¹ˍFƏ@Ϧĝςäŵį ƙ Ć ƕ æ Ü Û ĝ Û ʦ ƨ K f Ħ K ` ; ·ˏ̪Kæ0Ħĝf;ĜKŃøςäŵÝɪƕ­ Ĝ[33-34]ÆȻKƙϡæ̋`ıLJ͈fΣɩuξÝ ϤÛʦƨKhƏűόĝʳDſ[21-22]ςäŵÝ jąĝέÛʦ ŋ_Ə^_CKƙȁ@ĆLJ̼ɡäǂĝȪć ˠɣŵΛΓέÛʦÝòΧŋ˼ȚCƏųu̜ ſKÝKϙ͇_ƏáÝ9ÆKäǂĆƕ˴͇ ˍ¹˼Ň¹CKĕƁΓ·̨όſ˗Kŋ_͇ǜ ʃʦD`Ά;njǂ˼NćD`Ά;njǂä ɒ[35-36]ÆȻKnˠɣŵæϠºƋ3ʦĝΨšljKK ǂĝ̼͸ʦŨ˼Ûʦ͸Ǔ͇ΓȪćſ˼Γǫǰ 9 Æ ˠ ɣ ŵ ɡ Ά ĝ ƨ T R ɡ Ć Û ʦ ˵ ` ƘŰ4˵ʩäǂuæÛʦC͇Ûʦ˵`͇ ͇[37-38]ˠɣŵɦέÛʦKjςΆˠɣŵÍ@Άˠ ʕÖ°͇ʕŵÛʦ̚Ȱ͇ÖəÛʦÛʦͻ͇ ɣŵÍΆˠɣŵÍΆςΆˠɣŵÍ@Άς ΛŸͻȔh[23]ƙϡ̋`ȁˎ̼͸ŋCKΛnʦ Άˠɣŵ˼ÎςΆˠɣŵuşKŋ_͇KΓƘǓ ̜ɍΟ_¹ɍC ͇Kju·_άƏĝ_C͇KŹ͇̓ɡΛÛʦͻ ÆȻKäǂ`Ά˼ÍΆΆȞæ̋`ıljKƯ ͇[39-41]ˠɣŵĉέÛʦKjÒžˠɣŵÒžˠɣ ƷÛ̼͸)͇KøΓuɒ̼͸ȁh͇h`Άĝ ŵˠɣŵNjžĉKϡĆˠɣʗ́fƨÆȻKƙ ̼͸͑čͮÚȪćſK9ÆȋƔƖĜĖĝƨó ɜĝǫǰƘæĆƗƕƗϊĝK9Æƙɜĝŋ_̚ſ uυŦǰ͇Ɖäǂ`_CÝ˵Ƌ0ĦĝpHŴ ˼˰Ǔ͇æTŐŜŃ̜ǓļøΓKhÝΣƕϘʦ 5158 P.O. Box 10002, Shenyang 110180 ɏΜΟ ਍. ]Ȑϛńசɳ҉ᱷįѥĐǧ͏ћՈۘऺ^àϬ ƅά˼ɪƕÛʦ͸Ə[40-42] æÔY͓ȉˍFùŲKùό°ĉ"^Ί˼Ϡºͷ (4)ŜŵYŜŵĉ"æÎνƏǫŦĜĖnΓ ̊́fKTţʌuŶǂ˥D¬÷˾[58-61] ƕ˲ĝÛʦ˵`͇ͻ˵`͇C͇ȴKȑΧ͇ (3)³αĉ´YlžnÝϘʦČǚ˼ȆŮɵ ˼Ùȑ͇KÝÛʦ͸ƏaěʩƿŜˠɣĆnˠ iˊȌƏu˵Ƌ0ɒĝόſ˼ĉĊĝCȁKĆɩ ɣĉ"(ŵ)̱˼ĉ"(Ŝ)ɞIƯf[43-46]Ɓ> ȋǐ̓ĝūǓȂĉŭāô°Klžuƕ˲ Ŝĉ"^ÔYɷ&ljKKĄŜĉ"æˏͮ9Û˵lj ĝ·̨Ǔ͇Cæõ͇˼ƕ˲ĝÛʦ˵`͇[51K62]K ĝ̚ˌÆȻKŜŵĉ"ˏʌŦs2͓ˍF˼fˠɣ >ƯΓόîĝħŋ͇˳ƅƤΓξÝĝKh·ž ˍFȰǢĤ˼ùŲKÔY¯ɻ˾[45-47] Ćdžɩ(αĉ)KΓϤŋ͇˼CŶſÝŋ_Ə (5);ǂY;ǂĆϤŋ͇ĝKŋ_͇ɒKÝÛ ͿÝǠˍ˵Ƌlž0ĉ[63]lžÍΆžu ʦˊȌƏɡƟ͇KæȁˎÍΆljKƷÛʪˏ̼[48]; ̋όĝÛʦ˵`͇KæõĝÛʦC͇KÆȻKƙæ ǂΛΓέÛʦuÛʦC͇KÛʦ˵`͇KÖĉ ξɵf͠Ɨ^ȅĝ́üKjǰʜâżˠɣġKʼ "ʳȰKEϟ^ÚˍFͻſ9ÆKƙĆɩƕ˲ ɬżǰlžÍΆžərhEGFTţʌǜɒfˠ ĝ˾ʦKhƟKhKjʘŇ͓˼͓˗˾˼ ɣˍFĝÛAȁ[58K61] Ϙʦ¦ĶƙuŶΨšˍF_vKÔYͻʭÛfˍ ΥˍĉĆdžɩuÛʦ˵`͇˼æÛʦ Fε Ė¬÷ǂā;ǂ˾ʦTKhǂ CĝĉKnƙæÔY¬÷ɯĉ˾EϠºΨšlj ˥D͉ŀbĞςͿ¬÷ɃAƏ[49] KKThȆŮÜÛ˼¬÷˾ǒɻĝΡ~Υ ȖzȌt༞Ȍĭ7ZՈசɳ҉ᱷįѥϛ* ˍĉCŶȁ0lž ·ž˼lžÍΆ (1)ʾ·Yʾ·ĆuϤŋ͇ʕŵʕ žʌ˩͇ȴ[58-59] ƁXKl·CŋC`CĜĖĝÒžʾĉÛʦ˵ 2.3 =Ǫ [͞|ġì˼ċŪȽą ˫8ƅKŌƋǂ `͇ĝ˾ʦ[50-53] ʾ·TʴǏhȆŮɵ ˥DȀĞςĝƍƟǒƽuÖ¹ϘʦÛA9ǰ¦Ȍ i˼ϘʦģŪKƤƙĝɒϤŋ͇˼ʳŋˏſKƙ͆ ϘʦțƹƟƽΛ¯÷ȈƨĝKhġǂ˥DȀAΉ æTƅȔfâżˠɣǙŮͦ˒ɵġ́üÆ Ğς˼ΠƗɃAĆĕƁ͂9ŪĝƗϙ°99ÆK ȻKƙuƕ˲ĝ̼͸˼ɍ͇ˏKΛƕ˲ĝ̚Ȱ͇ ¬÷̱ŨÖÛŵøhƋ¬÷˾˼ȆŮ͑ȧϡΖɡ ˏ˼φÙȑ>ƯKʾ·2˫̜^Ŷĝ·̨ ƗϙKÖ¹άĝͲô̋îiſ°$µəÛʦ͸ĝļ ͇ˏ(jόſ˼Ĉ͇)Λ˵Ƌ0-ĝKɿş͇ʾ Ʋ­ͯʑ˼ɃAΠƗiſ ·̋`_CK9Æ^æˏĆɩAΉͿe͇Ȉ uã͸νΡ~2ʌKį·¦ȌϘĝǧ>˾f ƨʾ·ΛΓέÛʦThȔ@ʷ¬÷ȈƨKE 9ʦijΡLˊȌűʦƏáÝĝɪƕÛʑɣs Ƌǂ˥D¯ɻƍƟY̓Ƥ!ē[54]ÆŭȻK fǫKæhʦ̜ɃA͇ΝD˼ȴ͇¬÷ĝƍƟ ʾ·ɡΆĝȈƨ͆TξÛuÛʦͻ͇ĝ̼˾ʦK ampucareĆƏϘfǫKΓͻ͇fǫƶϙĆF˼ jîɎŵ˼̈́@̺Ö¹Ϙʦĝu̚ČǚKæˏu ͓KijƕrΆϘʦKhbƍƟ¶¬¯ɻ ƹȷ§AΉ˄˾ĝEƷš ¯ɻġKuÖΨ˼Ö¹͇ˏKȅðϡǜɒƤ¯ɻͻ (2)Ƶ·«̈́φɂYƵ·Ćƕɦ ǐƘKuƃǢȆŮÜÛΟĖɷ&Ő;Ȕhĝɷˏ] ϡTcɡ̈́φɂͿφ̼ʾKŃ$µƙĝǫ Å΄ŐʌĆƕhbƍƟǂ˥D˗ŪĞς(& ǰƉƘƙuϤŋ͇Ûʦ˵`͇Ĉ͇ʕŵ͇ &Ļ˼ȡ)ϘʦKijͻ̔0·͇ÛA9ǰśϘʦK ˼ǜɷ&°͇ĝʦƉKÖĉ"ʳȰKEϟæȁˎ<Ŧ æÔYˍFĝǫƪ˼̵ĝ͓ȉĝ́fȁˎîIJǂ˥ ǰͿυŦǰ˾ljK˾f̈́φɂ[55]Ƶ·͆æ Dʖ̀ēκ2ʌKampucareƍƟȆ0]Å΄Őʌƍ ΓƘ˾ʦʃ͹Kjäǂlž·ž˼ ƟȆÝÝǂ˥Dʖ̀îIJĝ¬÷˾Əĝɷ̚ɯ ȮȤžKǜɒΓʝuĝ_CſϣóK͇ˏ ˲[20] ſ͸͇ˏΛBfſ˼̚ſΆƵ·σƅʃʦ Ɨ̃Ρ~QęæøhțƹƟƽȷ§ǂ˥DȀ ĝ́fϡĆɩæ̓ĝͲô Ğς¬÷ɃA˾ēŃ̜țƹæèGģȭΊ¬ ΆƵ·ĝŋ˰Th͠ƗÛʦ͸ ÷ƍƟ[7]ƗȆżˍFΚțÇΏ9ǰˊȌ͇ɒΊφƟ ƏKGģ¬÷Ȉƨ[56-57]ÆȻK9ɡŃƕś̀ĝŋ˰ ƽ|()Ɵƽ˼ǹɰĝøh[30K33] ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH 5159 ɏΜΟ ਍.
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    Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 904958, 21 pages http://dx.doi.org/10.1155/2014/904958 Review Article Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines Norman Ratcliffe,1,2 Patricia Azambuja,3 and Cicero Brasileiro Mello1 1 Laboratorio´ de Biologia de Insetos, Departamento de Biologia Geral, Universidade Federal Fluminense, Niteroi,´ RJ, Brazil 2 Department of Biosciences, College of Science, Swansea University, Singleton Park, Swansea SA2 8PP, UK 3 Laboratorio´ de Bioqu´ımica e Fisiologia de Insetos, Instituto Oswaldo Cruz, Fundac¸ao˜ Oswaldo Cruz, Avenida Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil Correspondence should be addressed to Patricia Azambuja; [email protected] Received 1 December 2013; Accepted 28 January 2014; Published 6 May 2014 Academic Editor: Ronald Sherman Copyright © 2014 Norman Ratcliffe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except for honey as food, and silk for clothing and pollination of plants, people give little thought to the benefits of insects in their lives. This overview briefly describes significant recent advances in developing insect natural products as potential new medicinal drugs. This is an exciting and rapidly expanding new field since insects are hugely variable and have utilised an enormous range of natural products to survive environmental perturbations for 100s of millions of years. There is thus a treasure chest of untapped resources waiting to be discovered. Insects products, such as silk and honey, have already been utilised for thousands of years, and extracts of insects have been produced for use in Folk Medicine around the world, but only with the development of modern molecular and biochemical techniques has it become feasible to manipulate and bioengineer insect natural products into modern medicines.
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  • Myiasis During Adventure Sports Race
    DISPATCHES reexamined 1 day later and was found to be largely healed; Myiasis during the forming scar remained somewhat tender and itchy for 2 months. The maggot was sent to the Finnish Museum of Adventure Natural History, Helsinki, Finland, and identified as a third-stage larva of Cochliomyia hominivorax (Coquerel), Sports Race the New World screwworm fly. In addition to the New World screwworm fly, an important Old World species, Mikko Seppänen,* Anni Virolainen-Julkunen,*† Chrysoimya bezziana, is also found in tropical Africa and Iiro Kakko,‡ Pekka Vilkamaa,§ and Seppo Meri*† Asia. Travelers who have visited tropical areas may exhibit aggressive forms of obligatory myiases, in which the larvae Conclusions (maggots) invasively feed on living tissue. The risk of a Myiasis is the infestation of live humans and vertebrate traveler’s acquiring a screwworm infestation has been con- animals by fly larvae. These feed on a host’s dead or living sidered negligible, but with the increasing popularity of tissue and body fluids or on ingested food. In accidental or adventure sports and wildlife travel, this risk may need to facultative wound myiasis, the larvae feed on decaying tis- be reassessed. sue and do not generally invade the surrounding healthy tissue (1). Sterile facultative Lucilia larvae have even been used for wound debridement as “maggot therapy.” Myiasis Case Report is often perceived as harmless if no secondary infections In November 2001, a 41-year-old Finnish man, who are contracted. However, the obligatory myiases caused by was participating in an international adventure sports race more invasive species, like screwworms, may be fatal (2).
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  • Bugs As Drugs, Part 1: Insects. the “New” Alternative Medicine for the 21St Century? E
    amr Review Article Bugs as Drugs, Part 1: Insects. The “New” Alternative Medicine for the 21st Century? E. Paul Cherniack, MD Abstract estimates that $20 billion will be needed to replace Insects and insect-derived products have been widely used in the shortage of 800,000 conventional health care folk healing in many parts of the world since ancient times. workers by 2015.1 Globally ubiquitous, arthropods Promising treatments have at least preliminarily been studied potentially provide a cheap, plentiful supply of experimentally. Maggots and honey have been used to heal healing substances in an economically challenged chronic and post-surgical wounds and have been shown to be world. comparable to conventional dressings in numerous settings. Honey has also been applied to treat burns. Honey has been Maggots combined with beeswax in the care of several dermatologic The most well-studied medical application of disorders, including psoriasis, atopic dermatitis, tinea, arthropods is the use of maggots – the larvae of pityriasis versicolor, and diaper dermatitis. Royal jelly has flies (most frequently that of Lucilia sericata, a been used to treat postmenopausal symptoms. Bee and ant blowfly) that feed on necrotic tissue.2 Traditional venom have reduced the number of swollen joints in patients healers from many parts of the world including with rheumatoid arthritis. Propolis, a hive sealant made by Asia, South America, and Australia have used bees, has been utilized to cure aphthous stomatitis. “larval therapy,”3 and records of physician use of Cantharidin, a derivative of the bodies of blister beetles, has maggots to heal wounds have existed since the been applied to treat warts and molluscum contagiosum.
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  • An Initial in Vitro Investigation Into the Potential Therapeutic Use of Lucilia Sericata Maggot to Control Superficial Fungal Infections
    Volume 6, Number 2, June .2013 ISSN 1995-6673 JJBS Pages 137 - 142 Jordan Journal of Biological Sciences An Initial In vitro Investigation into the Potential Therapeutic Use Of Lucilia sericata Maggot to Control Superficial Fungal Infections Sulaiman M. Alnaimat1,*, Milton Wainwright2 and Saleem H. Aladaileh 1 1 Biological Department, Al Hussein Bin Talal University, Ma’an, P.O. Box 20, Jordan; 2 Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield,S10 2TN, UK Received: November 12, 2012; accepted January 12, 2013 Abstract In this work an attempt was performed to investigate the in vitro ability of Lucilia sericata maggots to control fungi involved in superficial fungal infections. A novel GFP-modified yeast culture to enable direct visualization of the ingestion of yeast cells by maggot larvae as a method of control was used. The obtained results showed that the GFP-modified yeasts were successfully ingested by Lucilia sericata maggots and 1mg/ml of Lucilia sericata maggots excretions/ secretions (ES) showed a considerable anti-fungal activity against the growth of Trichophyton terrestre mycelium, the radial growth inhibition after 10 days of incubation reached 41.2 ±1.8 % in relation to the control, these results could lead to the possible application of maggot therapy in the treatment of wounds undergoing fungal infection. Keywords: Lucilia sericata, Maggot Therapy, Superficial Fungal Infections And Trichophyton Terrestre. (Sherman et al., 2000), including diabetic foot ulcers 1. Introduction (Sherman, 2003), malignant adenocarcinoma (Sealby, 2004), and for venous stasis ulcers (Sherman, 2009); it is Biosurgical debridement or "maggot therapy" is also used to combat infection after breast-conservation defined as the use of live, sterile maggots of certain type surgery (Church 2005).
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  • 210818 the Principles of Maggot Therapy and Its Role in Contemporary Wound Care
    Copyright EMAP Publishing 2021 This article is not for distribution except for journal club use Clinical Practice Keywords Maggot therapy/Wound care/Wound healing Review This article has been Wound care double-blind peer reviewed In this article... ● Evidence supporting maggot therapy in wound care ● Indications for use and how the process works ● Patient perception of the treatment The principles of maggot therapy and its role in contemporary wound care Key points Author Yamni Nigam is professor (anatomy and physiology), College of Human and Maggot therapy has Health Sciences, Swansea University. been available on NHS prescription Abstract Maggot therapy is becoming increasingly established as an option for the since 2004 debridement and treatment of sloughy, necrotic wounds. Although used tentatively NT SELF- over the previous few decades, it became more widespread following its availability ASSESSMENT Maggots are on NHS prescription in 2004. Since then, the scientific and clinical evidence for the Test your clinically effective efficacy of maggot therapy has mounted considerably, and it has been shown to be knowledge. for the debridement effective, not only for wound debridement but also in reducing the bacterial burden After reading this of sloughy, necrotic of a wound and accelerating wound healing. This article reviews current evidence, article go to chronic wounds and discusses the clinical indications for use, and the rearing and clinical application nursingtimes.net/ of maggots, as well as patient and health provider perceptions of maggot therapy. NTSAMaggots If you score 80% Secondary benefits or more, you will of maggot therapy Citation Nigam Y (2021) The principles of maggot therapy and its role in receive a certificate include reduction of contemporary wound care.
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  • Antimicrobial Peptides Expressed in Medicinal Maggots of the Blow Fly Lucilia Sericata Show Combinatorial Activity Against Bacteria
    Antimicrobial Peptides Expressed in Medicinal Maggots of the Blow Fly Lucilia sericata Show Combinatorial Activity against Bacteria Anne-Kathrin Pöppel,a Heiko Vogel,b Jochen Wiesner,a Andreas Vilcinskasa,c Fraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Giessen, Germanya; Max Planck Institute for Chemical Ecology, Department of Entomology, Jena, Germanyb; Institute of Phytopathology and Applied Zoology, Justus-Liebig-University of Giessen, Giessen, Germanyc The larvae of the common green bottle fly (Lucilia sericata) produce antibacterial secretions that have a therapeutic effect on chronic and nonhealing wounds. Recent developments in insect biotechnology have made it possible to use these larvae as a source of novel anti-infectives. Here, we report the application of next-generation RNA sequencing (RNA-Seq) to characterize the transcriptomes of the larval glands, crop, and gut, which contribute to the synthesis of antimicrobial peptides (AMPs) and proteins secreted into wounds. Our data confirm that L. sericata larvae have adapted in order to colonize microbially contami- nated habitats, such as carrion and necrotic wounds, and are protected against infection by a diverse spectrum of AMPs. L. seri- cata AMPs include not only lucifensin and lucimycin but also novel attacins, cecropins, diptericins, proline-rich peptides, and sarcotoxins. We identified 47 genes encoding putative AMPs and produced 23 as synthetic analogs, among which some displayed activities against a broad spectrum of microbial pathogens, including Pseudomonas aeruginosa, Proteus vulgaris, and Enterococ- cus faecalis. Against Escherichia coli (Gram negative) and Micrococcus luteus (Gram positive), we found mostly additive effects but also synergistic activity when selected AMPs were tested in combination.
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  • Insect-Based Medicines: a Review of Present Status and Prospects of Entomo-Therapeutic Resources for Human Ailment Denisha Rajkhowa*, Rokozeno, M.K
    International Journal of Agriculture, Environment and Biotechnology Citation: IJAEB: 9(6): 1069-1079, December 2016 DOI: 10.5958/2230-732X.2016.00135.2 ©2016 New Delhi Publishers. All rights reserved ENTOMOLOGY Insect-Based Medicines: A Review of Present Status and Prospects of Entomo-Therapeutic Resources for Human Ailment Denisha Rajkhowa*, Rokozeno, M.K. Deka Department of Entomology, Assam Agricultural University, Jorhat- 785013, Assam, India *Corresponding author: [email protected] Paper No. 538 Received: 25 August 2015 Accepted: 24 December 2016 Abstract Insects and products derived from them have been consistently used as medicinal resources by human civilizations all over the world. The immunological, analgesic, antibacterial, diuretic, anesthetic and anti rheumatic property in the bodies of insects is now well recognized; however the immense scope for its exploration still remains untapped. The chemicals generated by insects for self defense can be used as medicinal drugs of enormous potentiality. Insects have long been utilized as significant dietary factor and remedy for illnesses in folk tradition. Such entomotherapeutic potential of insects can also make important contribution in conserving the biodiversity of insects. At present, insect based medicines are gradually on the rise and gaining popularity and relevance. Products based on insect-derived substances with conventional technologies will help in yielding further benefits. This review collates the most important works conducted on insects used for different
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  • An Unusual Case of Vaginal Myiasis Hannah Soulsby,1† Brian L
    JMM Case Reports (2016) DOI 10.1099/jmmcr.0.005060 Case Report An unusual case of vaginal myiasis Hannah Soulsby,1† Brian L. Jones,2 Michael Coyne2 and Claire L. Alexander2† Correspondence 1Clinical Microbiology, Glasgow Royal Infirmary, Glasgow, Scotland Claire L. Alexander 2Scottish Parasite Diagnostic and Reference Laboratory, Glasgow, Scotland, UK [email protected] Introduction: Myiasis, a term used to describe the infestation of a live animal by fly larvae, is rarely reported in human subjects. The adult fly lays its eggs on living tissue that progresses to become larvae that feed on living tissue having gone through three developmental stages known as the first, second and third instar. The larvae become pupae before finally developing into adults. Case presentation: We describe an unusual case of a 79-year-old female who collapsed in her garden and lay there for several days before presenting to her local hospital Accident and Emergency department with an infestation of larvae in her vagina labia, identified as those from the Protophormia species northern blowfly. After complete removal of the larvae using tweezers followed by cleansing of the affected area and a course of antibiotics, the patient’s condition improved. A follow-up review by the local gynaecology team revealed no evidence of further infestation. Conclusion: It is our understanding that this is the first highly unusual case of a blowfly larvae Received 8 June 2016 infestation to be reported in a human within the UK. Accepted 5 July 2016 Keywords: Myiasis; vagina; larvae; blow fly. Introduction maggots invading exposed, often wounded tissue, and feed- ing off of blood from the host that may ultimately result in Insects of the order Dipteran account for one of the largest death through extensive tissue damage.
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  • Antimicrobial Dressing for Diabetic Foot Ulcer Colonized with MRSA
    OnLine Journal of Biological Sciences Review Antimicrobial Dressing for Diabetic Foot Ulcer Colonized with MRSA Parthasarathy Ravichandran and Sai Prasad Chitti Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, India Article history Abstract: Wound healing in patients with diabetic foot ulcer differs Received: 24-05-2015 among people. The wound healing process was influenced by factors like Revised: 26-07-2015 nature of the wound, tissue and an immunity of a person. Any measure Accepted: 02-11-2015 taken to control bacterial colonies in wound plays a significant role in wound healing. However, recent emergence of Methicillin-resistant Corresponding Author: Parthasarathy Ravichandran Staphylococcus Aureus (MRSA) associated with chronic wounds created Department of Biochemistry health concerns worldwide. An MRSA colony present in diabetic wounds and Molecular Biology, vulnerable to prolong the wound healing has reported worldwide. Since Pondicherry University, MRSA are resistant to a wide range of antibiotics, choosing appropriate Pondicherry, India dressings to treat MRSA colonized wounds has become a challenge. Email: [email protected] Either synthetic or natural antimicrobial agents are used to develop dressings that combat against MRSA infections. In today’s practice, the incidence of chronic wounds and its associated socioeconomic consequences is rising despite effort and advances in wound management. In this review, an attempt made to summarize various antimicrobial dressings based on its activity against MRSA. Keywords: Wound, Honey, Silver, Antimicrobial, MRSA Introduction derivatives, including Methicillin are used for the treatments of infections caused by Staphylococcus The estimated prevalence of diabetes covers 382 aureus (Rayner and Munckhof, 2005). The misuse and million people (Tao et al ., 2015).
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  • The Insect Economy
    THE INSECT ECONOMY FAKULTÄT II – INFORMATIK, WIRTSCHAFTS- UND RECHTSWISSENSCHAFTEN THE INSECT ECONOMY SUSTAINABLE BUSINESS OPPORTUNITIES BASED ON INSECTS AS BIOLOGICAL RESOURCES DISSERTATION Submitted in Fulfillment of the Requirement for the Title of Doktor der Wirtschaftswissenschaften (Dr. rer. pol.) Maria Real Perdomo th Born on 24 of March 1984 in Halle (Saale) BIOGRAPHY First Supervisor: Apl. Prof. Dr. Klaus Fichter Second Supervisor: Prof. Dr. Bernd Siebenhüner Place of Disputation: Oldenburg - Carl von Ossietzky University of Oldenburg Disputation Date: 18.10.2018 I Maria Real Perdomo THE INSECT ECONOMY BIOGRAPHY Maria Real has a Bachelor in International Business and Intercultural Management (2009, Germany) and a Masters in Regional Planning and Environmental Manage- ment (2011, Spain). In 2013, she began working as scientific staff member at Heil- bronn University of Applied Sciences. The idea about writing about the Insect Econ- omy matured during the first conference about “Insects to Feed the World” in Wa- geningen 2014. During her research project, she participated in a number of confer- ences to present her ideas such as ISPIM in Hungary (2015) and Porto (2016), and the G-Form in Kassel (2015). At the G-Forum, the Hans Sauer Foundation awarded Prof. Klaus Fichter and her the Best Sustainable Entrepreneurship Research Award for their paper “Sustainable Business Opportunities in the Insect Economy”. Furthermore, to- gether with René Cerritos she published the article “Pre-Hispanic agriculture prac- tices: Using pest insects as an alternative source of protein” (DOI 10.2527/af.2015- 0017). Today, Maria is working as a business consultant in the area of innovation technology. II Maria Real Perdomo DANKSAGUNG (AKNOWLEDGEMENTS) DANKSAGUNG (AKNOWLEDGEMENTS) Meine besondere Anerkennung und Dank gilt meinem Doktorvater Professor Dr.
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  • Effectiveness of Chronic Wound Debridement with the Use of Larvae
    Journal of Clinical Medicine Review Effectiveness of Chronic Wound Debridement with the Use of Larvae of Lucilia Sericata Dariusz Bazali ´nski 1,2, Maria Kózka 3, Magdalena Karnas 4 and Paweł Wi˛ech 2,* 1 Father B. Markiewicz Podkarpackie Specialist Oncology Centre, Specialist Hospital in Brzozów, 36-200 Brzozów, Poland; [email protected] 2 Institute of Health Sciences, College of Medical Sciences of the University of Rzeszów, University of Rzeszów, 35-959 Rzeszów, Poland 3 Department of Clinical Nursing, Faculty of Health Sciences, Collegium Medicum, Jagiellonian University, 31-501 Krakow, Poland; [email protected] 4 New Medical Technologies, Holy Family Specialist Hospital, 36-060 Rudna Mała, Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-667-192-696 Received: 8 October 2019; Accepted: 29 October 2019; Published: 2 November 2019 Abstract: The process of successful wound healing depends on effective debridement and infection control. One method of wound debridement, known since antiquity, is based on the use of fly larvae. Solid scientific evidence proves that maggot debridement therapy (MDT), like surgical intervention, can be effectively and safely used to remove necrotic tissue. Based on a review of the related literature, this study was designed to assess the effectiveness of chronic wound cleansing with the use of larvae of Lucilia sericata (Phaenicia sericata). Maggot therapy, applied in wound debridement and treatment, is a safe and effective method. Its benefits are associated with debridement, disinfection and faster tissue growth. MDT may reduce the duration of antibiotic therapy and the need for hospitalization, or it may decrease the number of outpatient visits required.
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  • Maggot Debridement Therapy: from the Battlefields and Soldiers to Today’S Clinical Trials
    International Journal of Caring Sciences January-April 2021 Volume 14 | Issue 1| Page 787 Special Article Maggot Debridement Therapy: From the Battlefields and Soldiers to Today’s Clinical Trials Evangelia Meimeti, RN, MSc, PhD Postdoctoral Researcher Department of Pharmaceutical Technology- National and Kapodistrian University of Athens. Training Coordinator for the Nursing Specialty "Public Health / Community Nursing" in Central and Western Macedonia, 3rd Regional Health Authority of Macedonia, Thessaloniki, Greece Elissavet Lykoudi, RN MS PhDc General Hospital of West Attica «Agia Varvara», Greece Evangelia Arapostathi, PhDc Laboratory of Agricultural Zoology & Entomology, Department of Crop Science, Agricultural University of Athens, Greece Antonios E. Tsagkarakis PhD Laboratory of Agricultural Zoology & Entomology, Department of Crop Science, Agricultural University of Athens, Greece Niki Papavramidou, PhD Associate Professor, Medical History Museum, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece Michail Rallis, PhD Department of Pharmaceutical Technology - National and Kapodistrian University of Athens, Greece Ioannis Galanis, MD, PhD 2nd Surgical Department, School of Medicine, "G. Gennimatas" General Hospital, Aristotle University of Thessaloniki, Greece Correspondene: Evangelia Meimeti, RN, MSc, PhD Training Coordinator for the Nursing Specialty "Public Health / Community Nursing" in Central and Western Macedonia, 3rd Regional Health Authority of Macedonia, Mavili 11-Thessaloniki,Greece E-mail address: [email protected] Abstract Background: Although the advances in contemporary medicine have helped to improve the healthcare services, the wounds that do not heal remain a problem. Patients’ life expectancy has increased and many diseases are now considered chronic. Objective or Aims: The present historical study explores the important use of Maggot Debridement Therapy in clinical practice from antiquity to this day.
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