A New Guaianolide and Other Constituents from Achillea Ligustica
Available online at www.sciencedirect.com Biochemical Systematics and Ecology 36 (2008) 461e466 www.elsevier.com/locate/biochemsyseco A new guaianolide and other constituents from Achillea ligustica Azzedine Boudjerda a, Hanene Zater a, Samir Benayache b, Jean-Claude Chalchat c, Javier Gonzalez-Platas d, Francisco Leo´n e,f, Ignacio Brouard e, Jaime Bermejo e, Fadila Benayache a,* a Laboratoire de Phytochimie et Analyses Physico-Chimiques et Biologiques, Equipe Associe´e a` l’A. N. D. R. S., Universite´ Mentouri, Route de A€ın El Bey, 25 000 Constantine, Algeria b Laboratoire de Valorisation des Ressources Naturelles et Synthe`se de Substances Bioactives, Equipe Associe´e a` l’A. N. D. R. S., Universite´ Mentouri, Route de A€ın El Bey, 25 000 Constantine, Algeria c Laboratoire de Chimie des Huiles Essentielles, Universite´ Blaise Pascal de Clermont, Aubie`re, France d Dpto. Fı´sica Fundamental II, Servicio de Difraccio´n de Rayos X. e I.U.B.O ‘‘Antonio Gonzalez’’, Universidad de La Laguna, Avda. Astrofı´sico Francisco Sanchez 3, 38206 La Laguna, Tenerife, Spain e Instituto de Productos Naturales y Agrobiologı´a, CSIC, Instituto Universitario de Bio-organica ‘‘Antonio Gonzalez’’, Avda. Astrofı´sico Francisco Sanchez 3, 38206 La Laguna, Tenerife, Spain f Instituto Canario de Investigacio´n del Cancer (ICIC), Avda. Astrofı´sico Francisco Sanchez 2, 38206 La Laguna, Tenerife, Spain Received 5 August 2007; accepted 16 November 2007 Keywords: Chlorinated guaianolide; Achillea ligustica; Asteraceae; Anthemideae 1. Subject and source The aerial parts of Achillea species are widely used in folk medicine (Orkiszewska et al., 1985; Simonpoli, 1993). The species of this genus, contain essential oils (Palic´ et al., 2003; Sadyrbekov et al., 2006), flavonoids (Valant- Vetschera, 1985; Krenn et al., 2003) and sesquiterpene lactones (Balboul et al., 1997; Todorova et al., 2007).
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