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Monthly Meeting Esselen Award Address Education Night at Northeastern U. By Prof. Richard DiMarchi 2nd Annual NESACS 2006 NESACS Election Golf Tournament Candidate Statements Announcement and Application 2nd Annual Northeastern Section ACS Golf Tournament The Northeastern Section of the American Chemical Society, Inc. Contents Office: Marilou Cashman, 23 Cottage St., Natick, MA 01760. 1-800-872-2054 (Voice or FAX) or 508-653-6329. NESACS 2nd Annual Golf Tournament ______2 e-mail: mcash0953(at)aol.com Any Section business may be conducted Noyce Scholars Program ______4 via the business office above. NESACS Homepage: May Meeting ______5 http://www.NESACS.org Education Night, Dr. Michael Gilbert of EIC Laboratories speaks on Sathish Rangarajan, Webmaster ACS Hotline, Washington, D.C.: “Nano-Structured Electrically Releasing Epoxy Adhesives” 1-800-227-5558 Introduction to Drug Metabolism 6 Officers 2005 ______Chair: ACS Short Course Patricia Mabrouk Chemistry Department, Northeastern University Medicinal Chemistry Symposium ______7 Boston, MA 02115 New Trends in Oncology, May 18th, 2006 at the Holiday Inn, Woburn, MA 617 373 2845; p.mabrouk(at)neu.edu Chair-Elect: Summerthing 2006______7 Mukund Chorghade Pawtucket Red Sox, Lowell Spinners, Boston Rox, North Shore Spirit, Nashua 14 Carlson Circle, Natick, MA 01760-4205 508-651-7809 and 508-308-3891 Pride and the New Hampshire Fisher Cats: Minor league alternatives to the Chorghade(at)comcast.net Boston Red Sox. Immediate Past Chair: Amy Tapper Martin Freier ______9 Peptimmune 64 Sidney Street, Suite 380, The Origin of the Gustavus John Esselen Award ______10 Cambridge, MA 02139 617-715-8005; amy.tapper(at)peptimmune.com By Myron Simon Secretary: Esselen Award Address 11 Michael Singer ______Sigma RBI By Richard DiMarchi 3 Strathmore Rd. Natick, MA 01760-2447 508-651-8151x291 msinger(at)sial.com NESACS Election______14 Treasurer: Candidate Statements for 2006 James Piper 19 Mill Rd., Harvard, MA 01451 Summary of Governance Actions ______27 978-456-3155 piper28(at)attglobal.net By Morton Z. Hoffman Auditor: Anthony Rosner Photos from the March Meeting by Ying Wei ______28 Archivist: Myron S. Simon Cover: Dr. Michael Gilbert (Photo: Courtesy of Michael Gilbert) 20 Somerset Rd. Newton, MA 02465; 617-332-5273 Deadlines: romysimon(at)mindspring.com Summer 2006 Issue: June 16, 2006 Trustees: September 2006 Issue: July 14, 2006 Joseph A. Lima, Esther A.H. Hopkins, Michael E. Strem, Councilors Alternate Councilors Term Ends 12/31/2006 Michaeline F. Chen Wallace J. Gleekman Catherine E. Costello Howard R. Mayne The Nucleus is distributed to the members of the Northeastern Section of the American Chemical Patricia A. Mabrouk Alfred Viola Society, to the secretaries of the Local Sections, and to editors of all local A.C.S. Section publications. Julia H. Miwa Barbara G. Wood Forms close for advertising on the 1st of the month of the preceding issue. Text must be received by the Dorothy J. Phillips David Warr editor six weeks before the date of issue. Term Ends 12/31/2007 Editor: Michael P. Filosa, Ph.D., ZINK Imaging Incorporated, 1265 Main Street, Thomas R. Gilbert Arlene W. Light Michael J. Hearn Timothy B. Frigo Waltham, MA 02451 Email: Michael.Filosa(at)zink.com; Tel: 781-386-8479. Michael Singer Mary Mahaney Associate Editors: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273 Pamela Nagafuji Mark Froimowitz Nancy Simons, Analytical Chemist, Corporate R&D, Boston Scientific Corp., Term Ends 12/31/2008 1 Boston Scientific Place A4, Natick, MA 01760-1537. Doris I. Lewis Patrick M. Gordon Email: Nancy.Simons(at)bsci.com; Tel. 508-650-8603; Fax 508-647-2329 Morton Z. Hoffman Michael P. Filosa Sheila E Rodman, Malden, MA. Email:serodman(at)hotmail.com Christine Jaworek-Lopes Lawrence Scott Mary Burgess Liming Shao Tel: 781-771-4116. Donald O. Rickter S. B. Rajur Board of Publications: Mary Mahaney (Chair), Martin Idelson, Vivian K. Walworth Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, Tel: 978-456-8622 All Chairs of standing Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050, Committees, the editor Tel: 781-837-0424; FAX: 781-837-1453 of THE NUCLEUS, and Contributing Editors: Morton Hoffman, Feature Editor; Dennis Sardella, Book Reviews; the Trustees of Section Calendar Coordinator: Sheila Rodman, email: serodman(at)hotmail.com Funds are members of the Photographers: Morton Z. Hoffman, Ying Wei and James Phillips Board of Directors. Any Councilor of the American Chemical Society Proofreaders: Donald O. Rickter, Myron S. Simon, Vivian K. Walworth residing within the section area is an ex officio Webpage: Webmaster: Sathish Rangarajan, sathish.rangan2(at)gmail.com member of the Board of Directors. Copyright 2006, Northeastern Section of the American Chemical Society, Inc. The Nucleus May 2006 3 Noyce NESACS Golf Tournament - Osmium Level Donor IRIX Scholars Students Corporate Patrons and Golf Platinum Program Win Awards AstraZeneca R&D Boston Cardinal Health Funded by National Science DSM Foundation to Train Teachers in Germany Genzyme Drug Discovery & Dev. for City Schools By Morton Z. Hoffman Hovione IBM By Ed Hayward Dan Killelea, a graduate student in the Lyophilization Service of New Eng- A new University of Massachusetts Chemistry Department of Tufts Uni- land Boston project designed to prepare versity, received a third place award Phasex Corporation teachers of math and science for work for his oral presentation at the Eighth Strem Chemicals Inc. in the Boston Public Schools has Young Scientists’ Conference on Zone Enterprises Chemistry (Frühjahrssymposium), received funding from the National Corporate Sponsors and Golf Science Foundation that will support which was organized by the Younger Chemists Committee (Jungchemikerfo- Gold 39 graduate and undergraduate stu- Aerodyne Research Inc. dents in their teacher preparation stud- rum-JCF) of the German Chemical Society (Gesellschaft Deutscher Cambridge Isotope Laboratories ies over the next three years. New England BioLabs, Inc. Building on the university’s model Chemiker-GDCh) in Konstanz, Ger- many, March 16-18, 2006. Killelea, a Pfizer urban teacher training program, Teach Rhodia Pharma Solutions Next Year, the Noyce Scholars Pro- graduate student of Prof. Arthur Utz, spoke on “Controlling Surface Chem- Sigma-RBI gram will focus on undergraduate and Teledyne ISCO graduate students preparing to meet the istry via Selective Excitation of Rovi- high demand for subject-trained math brational States.” Donors and Golf Silver and science teachers in the classrooms Two other NESACS students Consulting Resources Corp. Dishman Pharmaceuticals and Chem- of the 21st century. received certificates citing the excep- icals Limited “We’re delighted the NSF has tional quality of their research posters: Vikki Tsefrikas, a graduate student in Houghton Chemical Company funded this program,” said Professor Organix Inc. Lisa Gonsalves, a member of the team Prof. Lawrence Scott’s laboratory at Boston College, on “Progress Toward Peptimmune that secured the grant. “The university Vertex has established an award-winning col- the First Chemical Synthesis of a Sin- laboration with the Boston Public gle Walled Nanotube” and Leland Schools and the Graduate College of Johnson, a graduate student at Boston University with Prof. James Panek, on Education has a proven record of teach mathematics or science in the preparing teachers for urban class- “Expansion of [4+2] Annulation Strategies.” ◆ Boston area during the next three rooms. years. The program will work in part- As with the seven-year-old Teach nership with Boston schools so that Next Year program, which successfully will assist 18 graduate students and 21 teacher training and professional guided graduate students through undergraduate students with tuition, development programs meet the needs courses and internships at the second- fees and other expenses during their of the city and the state. ary Dorchester Education Complex studies and assist graduate students The Noyce Scholars team consists and sent 19 teachers on to the BPS, the during their internship year in a Boston of Graduate College of Education fac- Noyce Scholars will focus on the criti - Public School. Eligible candidates will ulty Lisa Gonsalves, Assistant Profes- cal need for trained math and science have at least a 3.0 GPA, demonstrated sor of Literacy and Assessment, and teachers in urban school systems. strength in mathematics or science, and Jorgelina Abbate-Vaughn, Assistant In Massachusetts, more than 30% an interest in and commitment to Professor in Curriculum and Instruc- of the newly-hired math teachers are teaching. tion; College of Science and Math fac - not licensed to teach the subject, as are The goal of UMass Boston’ s ulty Brian White, Assistant Professor 29% of their science counterparts, Noyce Scholars Program is to increase of Biology; and Marietta Schwartz, according to the Massachusetts Depart- the number of qualified Science, Tech- Associate Professor in Chemistry. Ali- ment of Education. nology, Engineering, and Mathematics son Skerrett, of the GCOE, will serve The $500,000 Noyce NSF grant (STEM) graduates who are qualified to as project coordinator. ◆

4 The Nucleus May 2006 Monthly Meeting Abstract The 870th Meeting of the Northeastern Section of the American In addition to low cost, adhesive bond - ing offers many advantages including Chemical Society the ability to join dissimilar materials, Education Night the formation of a sealed and aestheti- Thursday, May 11, 2006 cally pleasing joint and the uniform dis- tribution of stresses across that joint. Northeastern University, 360 Huntington Avenue, Boston, MA However, bonds formed with structural 5:15 pm Social Hour, (Ballroom on the second floor of Curry Student Center) adhesives are essentially permanent. 6:00 pm Dinner No simple, non-destructive method exists for the disassembly of adhesively 7:00 pm Award Meeting, Dr. Patricia Mabrouk, NESACS Chair, presiding bonded manufactured goods, severely Address: Nano-Structured Electrically Releasing Epoxy Adhesives- hampering such operations as repair, Dr. Michael Gilbert, EIC Laboratories, Norwood, MA refurbishment and, of increasing impor- 7:45 pm Presentation of Awards tance, end-of-life recycling. For this Philip L. Levins Memorial Prize reason, design for the environment James Flack Norris/Theodore William Richards Awards (DfE) strategies promote the use of Undergraduate Research Fellowships mechanical fasteners over adhesive Undergraduate Grants-in-Aid bonding whenever possible. The recent development of electri- Undergraduate Research Symposium cally releasing adhesives by EIC Labo - Project SEED Students ratories, Inc., goes far in overcoming Excellence in Teaching at the Secondary School Level this deficiency. Capable of forming Induction of New Members into Aula Landis strong bonds between metal substrates Avery A. Ashdown Chemistry Examination Awardees Continued on page 8 Simmons College Price Dinner reservations should be made no later than noon, Friday, May 5th. network polymers into readily charac- Please call or fax Marilou Cashman at (800) 872-2054 or e-mail at terized fragments, allowing the effects MCash0953(at)aol.com. Reservations not cancelled at least 24 hours in of network formation on epoxy cure advance must be paid. Members, $30.00; Non-members, $35; Retirees, $20; reactions to be evaluated. Students, $10. From 1995 to the present, Dr. THE PUBLIC IS INVITED Gilbert has been employed as a senior Public transportation is strongly suggested. Take the Green Line E train to the scientist at EIC Laboratories, Inc., Northeastern stop, or the Orange Line to the Ruggles stop. Follow signs to the where he has performed research lead - board room or ballroom from there. Or, take the Orange Line to the Mass Ave ing to the development of a number of stop and go up the stairs at the west end of the platform, go through the turnstile novel coatings and adhesives, includ- and turn right onto the pedestrian overpass. Then make a left at the bottom of ing the invention of electrically releas- the stairs near the Gainsborough Parking Garage. Visit: http://www.cam- ing epoxies. This patented technology pusmap.neu.edu for a map of the Northeastern University Campus. A limited forms the basis for several commercial amount of parking will be allotted in the Gainsborough Parking Garage. Please products manufactured and marketed contact Marilou Cashman for a parking pass if necessary. Anyone who needs by EIC Laboratories. Dr. Gilbert has special services or transportation, please call Marilou Cashman a few days in continued this effort with the recent advance so that suitable arrangements can be made. development of new formulations exhibiting enhanced properties for more demanding environments. employed as a research chemist at the Dr. Gilbert received the 2000 Biography Army Materials Laboratory in Water- Technology Innovation Award from Michael Gilbert was born in Nashua, town Massachusetts. He specialized in Aviation Week and Space Technology New Hampshire. He received a B.S. research on adhesives and coatings. and the 2005 ACS Northeast Regional in Chemistry in 1980 from Rensselaer During this time, Dr. Gilbert elucidated Industrial Innovation Award for the Polytechnic Institute in Troy, New the mechanism of the dicyandiamide development of Electrically Releasing York and a Ph.D. in Polymer Science cure of epoxy resins using model com - Adhesives. Dr. Gilbert currently lives and Engineering in 1987 from the Uni - pounds and developed a diepoxide in Brookline, NH with his wife Teri versity of Massachusetts at Amherst. containing a chemically cleavable link- and their three children Michelle, From 1982 to 1995, Dr. Gilbert was age, which permits the digestion of Alexander, and Benjamin. ◆

The Nucleus May 2006 5 6 The Nucleus May 2006 Summer- Medicinal Thing 2006 Chemistry The Alternative to the Boston Red Sox Symposium After a very disappointing allotment of tickets to a Boston Red Sox game for New Trends in Oncology part of this year’s SUMMERTHING Organized by the Medicinal Chemistry Group 2006, members of the Board of Direc - of the Northeastern Section, American Chemical Society tors (led by Dr. Hoffman) came up with the fabulous idea of having our Thursday – May 18th, 2006 baseball games but using, instead of the Bosox, our minor league affiliates Holiday Inn, 15 Middlesex Canal Park Road, Woburn, MA lpcated within a reasonable drive from 3.00 pm Refreshments Boston (50 mi or less, 60min or less). These teams include: Pawtucket Red 3.15 pm Welcome Sox (44 mi, 45 min); Lowell Spinners Raj Rajur, Program Chair (26 mi, 35 min); North Shore Spirit (11 3.20 pm Introductory Remarks mi, 18 min); Worcester Tornadoes (44 Norton Peet, North Andover, MA mi, 50 min); Nashua Pride (45 mi, 45 min); Brockton Rox (23 mi, 30 min); 3.30 pm “Orally Active, Irreversible Inhibitors of Human Epidermal and New Hampshire Fisher Cats (50 Growth Factor, Receptor-2 (HER-2) Kinase”. mi, 60 min). Hewi-Ru Tsou,Chemical & Screening Sciences, Wyeth Research, Additionally, prices are inexpen- Pearl River, New York sive enough that you can take the 4:30 pm “Targetting Histone Deacetylase: Development of Vorinostat whole family to the ballpark for about (SAHA) for Treatment of Cancer” the price of one Boston Red Sox ticket. We have concentrated on weekends Paul Secrist, Cancer Biology & Therapeutics, Merck Research when most people would be free. Con- Laboratory, Boston, MA cessions (hot dogs, soda, coffee, pizza, 5.30 pm Social Hour etc.) are also so much cheaper than in Boston. And parking - most fields have 6.30 pm Dinner adjacent free street parking, along with 7.45 pm “IAP Antagonists” garages and open lots where the cost is Christopher Straub, Novartis Institutes for Biomedical Research, $2-4 rather than $20-25. We have tried Cambridge MA to select a variety of venues and dates that should satisfy most everyone. We Dinner reservations should be made no later than 12:00 noon on Thursday, would like to go as a group to each of May 11, 2006. To make reservations, please contact Marilou Cashman at (800) the games listed below. If, for some 872-2054 or (508) 653-6329 or [email protected]. Reservations not can- reason you cannot make some of the celed at least 24 hours in advance must be paid. Members, $28.00; Non-mem - dates, we have provided a telephone bers, $30.00; Retirees, $15.00; Students, $10.00. Anyone who needs number and a web site address so you handicapped services/transportation, please call a few days in advance so that can obtain information and a home suitable arrangements can be made. game schedule and then make your A. From Boston - Cambridge - Points North: Take Route I-93 to Route own personal arrangements. 95/128 West. After 1 mile, take Exit 35 South to Route 38 (Main Street). Pawtucket Red Sox - AAA vs. Buffalo Bisons *After about 500 feet at the traf fic light, turn right into Middlesex Canal Street Sunday, April 23, 1:05 pm to the hotel entrance. (McCoy Stadium - Exits 2A (MA) or B. From the West: Take Route 95/128 North to Exit 35 South (Route 38 - 29 (RI) off l95) Main Street. Follow directions from * above. Worcester Tornadoes – A THE PUBLIC IS INVITED vs. New Jersey Jackals Sunday, May 28, 2:05 pm Continued on page 26

The Nucleus May 2006 7 Hoffman To Receive Abstract Continued from page 5 (>3000 psi in shear), these adhesives Outstanding Professional release their grip when a low power current (10-50 volts d.c.) is applied Achievement Award across the substrates. The current induces electrochemical reactions at the Morton Z. Hoffman, Professor Emeri- Metcalf Cup and Prize for excellence adhesive metal interface, which greatly tus of Chemistry at Boston University, in teaching from Boston University, weaken the bond. Within seconds the will receive the 2006 Hall of Fame the 2002 Responsible Care® Catalyst substrates can be snapped apart. The Outstanding Professional Achievement Award for excellence in chemistry process is efficient, typically requiring Award from the Alumni Association of teaching from the American Chemistry less than 1 milliamp/cm2 of bond area. his alma mater, Hunter College of the Council, the 2003 John A. Timm There is no heating of the bond and no City University of New York, accord- Award for encouraging young people generation of gaseous or liquid wastes. ing to Jane Oppenheim, a member of in the study of chemistry from the New The positive metal substrate is left free the Board of Directors. England Association of Chemistry of adhesive and is immediately ready Hoffman, a graduate in the class Teachers, and the 2005 James Flack for reuse. Currently available as com - of June 1955 as a chemistry major, will Norris Award for Outstanding Teach- mercial products, electrically releasing receive the award at the 136th annual ing from the Northeastern Section of adhesives find use for both permanent Birthday Luncheon of the Alumni the American Chemical Society. He and temporary bonding and can be Association at the Sheraton Hotel in was the 2002 chair of the Northeastern employed to construct lightweight, New York City on Saturday, May 6. He Section, the 2005 chair of the Division inexpensive, highly adaptable release will be presented to the elected 2006 of Chemical Education of the Ameri- devices that are used in diverse appli- Hall of Fame members on Friday can Chemical Society, and is currently cations. evening, May 5, at Hunter College by a Councilor for the Northeastern Sec- The approach used in the formula- Jennifer J. Raab, its president. tion and a member of the American tion of electrically releasing adhesives The Hall of Fame was established Chemical Society Committee on Edu- will be presented. A key feature of this in 1972 to recognize Hunter graduates cation. In 2004 he was appointed U.S. technology is the development of self- who have made significant achieve- National Representative to the Com- structuring epoxy resins. Comprising a ments and contributions to society. mittee on Chemistry Education of the blend of amine-cured epoxy and a Hoffman was elected to the Hall of International Union of Pure and block copolymer, this resin undergoes Fame in 1977; recipients of the Out- Applied Chemistry. ◆ a sequential phase separation during standing Professional Achievement cure, leading to the formation of co- Award are chosen from among mem- Action Item continuous networks of rigid epoxy bers of the Hall of Fame. Previous and an electrolyte containing second awardees include Nobel Laureates phase material. Separated on the nano- Rosalyn Yalow and Gertrude Elion. Call for scale, the epoxy network provides A graduate of the Bronx High mechanical strength to the adhesive School of Science, Hoffman went from bond, while the second phase material Hunter College to the University of Nominations provides a level of ionic conductivity Michigan, where he received the Ph.D. Henry A. Hill Award for sufficient to support Faradic reactions degree in physical chemistry in 1960. Outstanding Service to the at the adhesive/metal interface. The He then spent a postdoctoral year at Northeastern Section presentation will provide a discussion Sheffield University, England, and of the properties and applications of joined the faculty of Boston University Nominations for the Henry A. Hill the electrically releasing adhesives, as in 1961. The author of almost 200 pub- Award for Outstanding Service to the well as potential applications for this lished papers with his graduate and Northeastern Section are invited. Nom- unique nano-structured material. ◆ undergraduate students, postdoctoral inations should be sent by July 1, 2006 associates, and visiting scholars in the to the Administrative Secretary, peer-reviewed chemical literature in NESACS, Marilou Cashman, 23 Cot- the area of the photochemistry and tage St., Natick, MA 01760. A resumé photophysics of transition metal coor- of professional activities and descrip- dination compounds, Hoffman was tion of the nominee’s service to the elected a Fellow of the American Asso- Northeastern Section should be ciation for the Advancement of Sci- included. The Award is presented at the ence in 1992. He received the 1994 October meeting of the Section.

8 The Nucleus May 2006 Martin Freier NESACS 1935-2006 Members to Run for ACS American Chemical Society member and writer Martin Freier died on Janu - ary 7th, 2006 from pancreatic cancer. Governance He is survived by his wife, his two daughters, his brother, and nieces and Positions nephews in New Jersey, New York and California. Three NESACS members will be can- Martin was born in Michalovce, didates in this year’s ACS elections. Czechoslovakia in 1935 the fourth of Bassam Shakhashiri (University of five children to Anna and Joseph Wisconsin, Madison), an honorary Freier. He was a Holocaust survivor member of the Section, was selected and studied the violin during his early by the ACS Council in Atlanta as a years before coming to New York in where he interviewed local personali- candidate for 2007 President-Elect; he 1949. He learned English and excelled ties and authors that aired on Framing - will be opposed by Bruce Bursten in science and music in high school ham State College’s radio station and (University of Tennessee). In an ear- and graduated from Talmudical Acad- its broadcast channel for the blind. lier vote, Councilors selected Tom emy in three years. He was accepted In 2002, Martin rediscovered his Gilbert (Northeastern University) and early into the honors program at interest in chemistry and became an incumbent Anne O’Brien (Wyeth- Brooklyn College, where he further active member of the American Chem- Ayerst Research) as candidates for Dis- developed his love of science and tech- ical Society. In 2004 he became a con - trict I Director for a 2007-09 term. nology. He graduated with honors with tributing writer to the Northeastern The Committee on Nominations and a B.S degree in Chemistry in 1958. Section’s monthly newsletter, The Elections announced in Atlanta the He worked for three years as a Nucleus, writing on topics including selection of six candidates for the three chemist in the pharmaceutical and food stem cells, genomics, obesity, home- Director-at-Large positions that are industries, and then began to take night land security, fuel cells, nanotechnol- open for a 2007-09 term, one of whom classes in technical writing at New ogy and alternative fuels. Martin was is Dorothy Phillips (Waters Corpora- York University. His technical writing deeply interested in expanding his tion); the other candidates are Jack career took off, and after several years knowledge by interviewing leaders in Breazeale (Francis Marion University), of working for large electronics corpo- cutting edge uses of chemistry and incumbent Dennis Chamot (National rations, he was recruited into manage- then sharing this newly acquired Research Council), Peter Dorhout ment at Raytheon Corporation in 1967. knowledge with the readers of The (Colorado State University), Paul He relocated to the Boston area. As a Nucleus. Jones (University of North Texas), and program manager at Raytheon, Martin In Martin’s personal life, he was Valerie Kuck ( Bell Laboratories). worked under security clearance with an active member of Temple Israel of The ACS elections will be held in the military and scientists and special- Natick where he was a Trustee, and he the Fall. All ACS members will vote ized in radar, computers, and air traffic donated his services as the cantor at for President-Elect, members in Dis- control landing systems. Martin was an the Chabad Center of Natick for 18 trict I will vote for its Director, and award-winning technical writer and years. He also was a volunteer for the Councilors will vote for the Directors- was on the board of the Massachusetts Brockton chapter of the Service Corps at-Large. ◆ chapter of the Society of Technical of Retired Executives (SCORE), where Writers. He received his MS in Engi- he advised clients on small business neering Management from Worcester issues from financing to sales for 15 Polytechnic Institute in 1978. years. He published a book of poetry Martin retired from Raytheon after called Hidden Truths and wrote his Adobe Acrobat files at the Northeast- 25 years of service in 1992. He began memoirs chronicling his early years in ern Section’s website: a second career as a consultant and Europe during World War II. He was a http://www.nesacs.org/TheNucleus/the writer. In addition to his consulting devoted father and husband. nucleus.html. Martin’s first article projects, he was a contributing colum- (Editors Note: Background infor- appeared in Vo.l 83, Issue No. 3, and nist to the MetroWest Daily News for 2 mation provided by Pearl Freier. Back his final article appeared posthu- years. He also had a radio program issues of The Nucleus are available as mously in Vol. 84, Issue No. 6.) ◆

The Nucleus May 2006 9 by the members of the Northeastern The Origin of the Gustavus Section, one appointed by the president of the American Chemical Society, one appointed by the president of the John Esselen Award National Academy of Sciences, and the By Myron S. Simon, Ph.D. Editor of Chemical and Engineering News. The Chair rotates among the In March, 1985, while I was Chair of solved the Section’s problems as they four elected members of the Section. the Northeastern Section, Arthur Ober- arose, an eminence behind the throne, No elected member can serve more mayer, a trustee and former Section as it were. His work in this Section had than two terms after the initial break-in chair, told me that he had been been so meaningful that he was the period in the 80’s. approached by Mr. Gustavus Esselen only former Chairman to receive a The new award was announced in III, who had asked whether the Section scroll of commendation for his service, C&EN 4/21/1986, p. 72. The first would consider establishing an organic the James Flack Norris Honor Scroll, solicitation for candidates for the chemistry award in honor of his father , in 1948. award was in 1987. The notice began Dr. Gustavus John Esselen, Jr. Esselen A meeting with Mr. Esselen took as follows: “The Gustavus John Esse- had originally been rejected by the place on May 1, 1985, with the follow- len Award for Chemistry in the Public national ACS when he contacted them ing NESACS members in attendance: Interest was established by the North- about such an award. Esselen then tele- Arthur Obermayer, William Foye, eastern Section of the American Chem- phoned Obermayer at the suggestion of Alfred Viola and myself. At that meet- ical Society in 1985. The award is a a mutual friend and business associate, ing we agreed to go ahead with the memorial to Dr. Esselen, a former out- Henry Avery, to determine if such an award. The prize would honor the standing member of the Section, and award would be of interest to the memory of Dr. Esselen and, with the was made possible by a major gift Northeastern Section. Obermayer Bhopal catastrophe fresh in our minds, from the Esselen Family. The goal of responded that there were already the award would be given to a chemist the award is to perpetuate Dr. Esselen’s awards for excellence in organic chem- whose scientific work had added to the belief that chemistry is an honorable istry, but that chemistry and chemists public well-being. Other aspects of the profession which contributes to the currently had a very bad public image, award, the desire to encourage recent public good. The award will annually and perhaps an award could be given work, the decision to limit the award to recognize a chemist whose scientific which communicated to the public the chemists living in the United States or and technical work has contributed to positive aspects of chemistry. Esselen Canada, financial details, and the desir- the public well-being, and has thereby agreed and expressed dismay that ability of a ceremony akin to that of communicated positive values of the DuPont had removed the last two the Richards Medal Award were deter- chemical profession. The significance words from their slogan, "Better mined at that meeting.2 of this work shall have become appar - Things for Better Living …Through In the name of the Esselen family, ent within the five years preceding Chemistry." Obermayer then amplified Mr. Esselen provided a large sum of nomination, and the Awardee shall be a on this award idea in a letter to money so that the award might last “in living resident of the United States or Esselen1 and contacted me as chair of perpetuity.” 3 Canada at the time of nomination.” the Northeastern Section to initiate the Mr. Esselen suggested that, in We knew that the early winner of process of getting Section approval. addition to the monetary award of the prize would set a pattern for the I appointed a committee consist- $5000, he would like to see a bronze award, and the fine tuning began ing of Truman Light, Arthur Ober- medal given, and, in memory of immediately. The first thing to be mayer, William Foye and myself to Dr.Esselen’s work on polymers, that changed was rhe idea that “A chemist” study the proposal and, with the further the medal be embedded in plastic. A would be the winner, for the very first help of Edward Atkinson, reviewed the picture of Dr. Esselen was provided. I award went to two men, Rowland and career of Dr. Esselen as it related to asked friends in the art world of Molina, for their work on alerting the this Section. There was no question; Boston to recommend a sculptor who world to the possibility of loss of the Dr. Esselen’s contributions had been could prepare such a medal and ozone protective layer. And the second many and important in the history of received the name of Lloyd Lillie, a award, a year later, established that the the Section. He had been an outstand- very fine choice. Mr. Lillie set about award was gender-neutral, as Joanna ing member of this Section, serving reducing the photograph to a bas relief, Fowler shared the award with Alfred twice as Chairman, was a member of and I did the reverse side of the medal Wolf for their work in positron emis- the American Chemical Society for 43 on my computer. sion tomography. years, serving National ACS as coun- The Award Committee, we The winners over the years have cillor and director for many of those decided, should represent multiple come from almost every branch of years. He had been the man the Section viewpoints. Accordingly, the Commit- chemistry. As the years go by, the went to for help, the councilor who tee consists of four members elected Continued on page 11

10 The Nucleus May 2006 Esselen Award Address Chemical Biotechnology as a Means to the Discovery of Optimized Protein-based Medicines Richard D. DiMarchi, Ph.D., Professor and Gill Chair of Biomolecular Sciences Department of Chemistry, Indiana University, Bloomington, Indiana 47405 RdiMarch(at)Indiana.edu

Over the course of the last three sis and solid phase chemical synthesis. commercial bioproducts are produced decades there has been a steady My interest in biosynthesis was at a scale that matches that of rDNA increase in the power of the technology embedded in the limitations I person- human insulin production in the early enabling the synthesis of peptide and ally witnessed in producing large quan- 1980s. proteins. Of equal importance has been tities of pharmaceutical-grade protein To satisfy the environmental the realization that nature did not with these synthetic technologies. safety regulations the first approach to evolve native amino acid sequence for Additionally, it was relatively easy to biosynthesis of insulin required indi- pharmacological purposes and that bet- see that rDNA biosynthesis would vidual biosynthesis of the biologically ter protein-based medicines could be eventually be utilized as a medicinal inactive A & B chains followed by obtained through sequence enhance- chemistry tool. their combination through disulfide ment. While I have had the great for- The human insulin experience was exchange to a properly folded native tune to work with peptides and seminal in providing the framework hormone. The significance of this proteins that have successfully found for future biosynthesis endeavors. In a undertaking is underscored by the fact medicinal use in several therapeutic relatively short period of several years that the total chemical synthesis of areas, the core of my contributions has this project advanced from the devel- insulin had not produced more than a resided in diabetes care. opment of the core technology to milligram of active hormone, and even I joined Lilly Research Laborato- biosynthesis of the first milligram and that was of variable quality. The cen- ries early in 1981 to participate in the eventually to the commercial synthesis tral synthetic limitation at that time and development of human insulin, what of hundreds of kilograms at a cost even today remains inefficient conver- would become the first rDNA-derived competitive with animal-sourced com- sion of highly pure A & B chains to protein approved for human use. It was mercial drug. It is important to note native insulin. a bold undertaking filled with a host of that only a tiny fraction of present day Continued on page 12 technical, financial, and emotional considerations. I came to the project having trained in two world-class labo- GATEWAY CHEMICAL ratories focused on protein semisynthe- TECHNOLOGY

Origin of Award CUSTOM SYNTHESIS Continued from page 10 • Pharmaceuticals importance of this award has grown, • Agrichemicals and the Gustavus John Esselen Award. • Combinatorial Platforms for Chemistry in the Public • Competitor's Products Interest.appears in the curriculum vitae • Intermediates of Nobel laureates and winners of • Analytical Standards some of the most noted chemistry and • Metabolites medical awards . PROCESS DEVELOPMENT (I thank Arthur Obermayer for helpful • Process Evaluation additions to this report.) • New Route Development Notes 1. Letter: A. Obermayer to G.J. Esse- SPECTROSCOPIC SERVICES • LCMS (APCI and API-ES) len, III, March 18, 1985 • NMR (300 MHz) 2. Notes: Meeting with G.J.Esselen,III • GCMS (EI) at MIT Faculty Club, May 1, 1985 11810 Borman Dr • Saint Louis, Missouri 63146 3. Letter: G.J.Esselen, III to W.O.Foye, 314.220.2691 (office) • 314.991.2834 (fax) November 12, 1985 ◆ www.gatewaychemical.com • [email protected]

The Nucleus May 2006 11 Esselen Address it liberated the supply of insulin from introduced. There was much resistance the availability and variable quality of to this thinking, derived internally Continued from page 11 animal-sourced pancreas. The global from the business sector that saw little Even seemingly established pro- epidemic of diabetes that is now well reason to repeat the expense of human tein chemistry such as cyanogen bro- established could have precipitated a insulin development. There was an mide cleavage presented challenges at rationing of insulin to those in greatest equal degree of opposition to the con- 1,000 liter scale that had been not need, a virtual return to the earliest cept of insulin analogs at the regula- observed previously at academic scale. days in commercial insulin supply. tory agencies. Their fear was primarily Cyanogen bromide was not available To the medicinal chemist the most the uncertainty of the unknown and a at the required scale and had to be pre - unsatisfying part of the human insulin core belief that any analog was des- pared immediately prior to use. Its oxi - experience was the size of the financial tined to be more immunogenic than the dizing properties complicated the investment relative to the improvement native hormone. As painful as it was, disulfide chemistry and initially gener- in pharmaceutical performance. The having waited sixty years for the deliv- ated a highly insoluble mixture of pro - change of a single alanine in porcine ery of human insulin, it was simply too teins that was virtually impossible to insulin for a threonine in human early to initiate an analog program. purify. Through the application of the insulin represented the addition of a Without support for insulin newly established technology of high hydroxymethyl group to a protein of analogs, my attention focused on the performance chromatography what six kilodaltons. There was no improve- biosynthesis of insulin-like growth fac- seemed like an impossible undertaking ment in glycemic control or hypo- tor 1 (IGF-1). It proved to be a seminal steadily evolved to a process that could glycemic response derived from the decision that later directed our work on be conducted reproducibly at a com- movement from porcine to human insulin analogs. IGF-1 is a highly mercial scale. insulin. In fact, no difference was homologous hormone to insulin but Human insulin proved to be a anticipated, as the chemical, physical, possesses considerably greater ana- commercial success. The competitive and biological properties of human bolic potency and much less glycemic process of producing human insulin by insulin are virtually indistinguishable activity. We developed a novel chemi- semisynthesis that was established by from that of porcine insulin. cal procedure for selective tryptophan Novo was replaced later in the decade Our vision was that the comple- peptide bond cleavage that served as a by a yeast-derived human insulin. The tion of the human insulin project estab- central step to the biosynthesis of IGF- most important contribution of rDNA- lished the foundation upon which 1. An immediate observation that derived human insulin was the fact that optimization of the hormone could be emerged from our early physical char- acterization of IGF-1 was the weak self-association behavior it exhibited relative to that of insulin. Our attention was directed to an unexplained amino acid sequence inversion in the C-terminal end of the B-chain. In all insulin hormones sequenced from more than twenty species, the lysine residue at position twenty-eight is always preceded by a proline. Quite unexpectedly these two amino acids were reversed in IGF-1. We hypothesized that the inversion in sequence might be the source of the differing physical behavior. We fur- thermore hypothesized that IGF-1’s binding to its circulating binding pro- tein would be impaired if its own self- Continued on page 13

Q. Exactly, how many awards and scholarships does NESACS sponsor? A) One b) Two c) Many www.nesacs.org/awards

12 The Nucleus May 2006 Esselen Address More importantly it was a first in demonstrating that careful design can NESACS Continued from page 12 lead to non-native protein structures association were a competing event. that are pharmaceutically superior to Insulin being stored as an inactive nature’s own sequence. Election hexamer in the beta cell of the pan- My most recent work at Indiana Election of Candidates creas would be equally compromised University and a biotechnology start- physiologically if its self-association up company in California named was impaired. Ambrx has taken me full circle. The In the interest of providing maximum The inversion of the native insulin core technology developed by Pete information and expression of opinion amino acid sequence at positions 28, Schultz has enabled the biosynthesis of by the candidates for election in 2006, 29 to replicate that of IGF-1 provided proteins with non-native, pharmaceuti- the Nominating Committee has pre- an insulin of identical amino acid com- cally preferred amino acids. In 2003, pared this section of the NUCLEUS position, isoelectric character, and Pete and I co-founded, with Troy Wil- for mailing concurrently with the bal- molecular mass to that of the native son, Ambrx as a means to enrich the lots. All candidates were asked to sub- hormone. The physical characteristics technology and to develop the first mit biographical material and, with the of the insulin analog were dramatically rDNA-derived protein for human use exception of committee member nomi- different than the native hormone. The that bears a non-native amino acid. I nees, position statements. To attain self-association was much weakened, have termed this technology chemical uniformity of format, the biographical but not absent. The profile seemed ide- biotechnology, since it represents data have been rearranged, and, where ally suited for development as a meal - biotechnology as we have come to the text exceeded the allotted space, time, fast-acting insulin. The low level know it over the last twenty-five years, abbreviated. The statements have been of self-association was sufficient to but married to the structural diversity reproduced without change. An official facilitate formulation as a solution sta- that has been restricted to synthetic and ble hexamer, but the weakened affinity semisynthetic approaches. An impor- ballot, along with a ballot envelope translated to a rapid dissociation and a tant priority of our work at Indiana and return envelope have been pro- near-immediate initiation of in vivo University is to deliver the third in a vided. The election and balloting are biological activity. series of improvements in insulin ther - being carried out in conformance with Lys-Pro human insulin demon- apy that started with native sequence Article VIII of the Constitution of the strated its virtues in animal and human and was followed by Lys-Pro insulin. Northeastern Section. The order of studies. Extensive toxicology studies Our objective is an insulin with sizably candidates for each office on the ballot illustrated that the interaction of the enlarged therapeutic index and without will be determined by lot. Comments hormone at insulin target tissues was requirement for injection. regarding the election may be virtually identical to native hormone, All that I have accomplished is a addressed to the Nominating Commit- but its altered physical character pro- direct function of the training, direc- tee Chair, Dr. Amy Tapper (address on vided pharmacokinetics that were ide- tion and support I have received from a p.3). ally suited for mealtime use as a very large number of dedicated indi- The ballot must be received by May subcutaneous injection. In carefully viduals. While the list is too numerous ◆ controlled clinical studies Lys-Pro to identify all such individuals, it would 31, 2006. human insulin has demonstrated be inappropriate not to recognize a few improvement in glycemic control of key individuals. Drs. Bruce Merrifield, nearly 50%, while lowering the preva- Ron Chance, Gus Watanabe introduced What’s Yours? lence of hypoglycemia by more than me to peptide synthesis, insulin, medi- DMPK Scientist, 30%. Additionally, Lys-Pro insulin is cine and chromatography. More impor- LC/MS Product Specialist, much more convenient in that it is used tant than their technical expertise was Mass Spec Operator, at the time of need as opposed to the the highly individual manner in which Staff Investigator, ADA recommended instruction of 30- they demonstrated utmost scientific Process Chemist, 45 minute pre-injection for the native integrity and a higher purpose to their QA Manager, insulin. This insulin analog is presently professional activities. I am also Synthetic Chemist, used by millions of diabetics each day. deeply grateful for the administrative Lab Instructor . . . support I received from Mr. Steve Looking for seminars in Neal, Dr. Troy Wilson, and Ms. Teri Many local employers post positions the Boston area? Layton. Lastly, it has been the uncon- on the NESACS job board. ditional support I have received from Check out the NESACS Calendar my wife, daughters and extended fam- Find yours at www.nesacs.org/seminars ily that has made all of this work possi- www.nesacs.org/jobs ble and meaningful. ◆

The Nucleus May 2006 13 NESACS has a long history of manag- NESACS Election ing to do just that, and once identified, we do an outstanding job of develop- Election of Candidates 2005 ing and maintaining those areas. Dur- ing my tenure on the Board of Chair-Elect since 1980 (Student Affiliate, then Publications, we worked together to Member). Hospitality Volunteer, 1989 Marietta Schwartz dramatically improve the Section’s National ACS Meeting, Boston. website in time for the most recent NESACS Service: Volunteered for National ACS Meeting held in Boston. the Education Committee for a number This was a challenge, but we rose to of years. Sole coordinator in charge of the occasion and I think that we should recruiting and assigning student work- all be extremely pleased with the ers for the ACS National Meeting in results. I hope to continue working on Boston, August 1998 and again in projects such as this, as I feel it is the August 2002. Secretary, Board of Pub- role of the Chair to work with the lications, Northeastern Section of the membership to continue to identify American Chemical Society, October such areas and to do our best to work 1999 - December 2000; calendar year together, to bring our expertise to the 2002. Chair, Board of Publications, table and to the community Education: 1983-1988: University Northeastern Section of the American of Wisconsin - Madison. Ph.D. Degree Chemical Society, calendar year 2001 in Organic Chemistry was conferred in and 2003. Currently chair of the Norris August, 1988. Dissertation title: “Syn- Award Committee. TREASURER thesis and Study of Two Tribridged Memberships, Honors: American Cyclophanes”. Research Director: Chemical Society (Organic Division, James U. Piper Prof. Howard W. Whitlock, Jr.; 1979- Division of Chemical Education, Education: B.S. MIT; M.S., Ph.D. 1983: College of St. Benedict, St. Northeastern Section), Iota Sigma Pi Emory University. Joseph, Minnesota. B.A. in Chem- national honor society (Member-At- Professional Experience: Research istry– was conferred in May, 1983. Large), Association for Women in Sci- appointments at Yale U. 1963-6, MIT Professional Experience: January ence 1966-7 and 72-3, Worcester Founda- 2004-Present: University Director of Statement: NESACS has a long- tion for Experimental Biology 1979- Undergraduate Education, University standing tradition of excellence, both 80. Teaching appointments at New of Massachusetts Boston; 1994-Pre- locally and nationally. I see the role of Haven College 1963-6, Simmons Col- sent: Associate Professor of Chemistry, the Chair as twofold: first of all to lege 1966-2002. Currently Emeritus UMass Boston; 1988-1994: Assistant maintain that tradition by careful Prof. Professor of Chemistry , UMass administration of the Section, and sec- NESACS Service: ACS Member Boston; 1983-1988: Research ondly to expand that tradition by iden - since 1960. 1990 Hill Award. Assis–tant/Teaching Assistant, Univer- tifying new and innovative areas in NESACS Treasurer Sept. 1977-pres- sity of Wisconsin Madison; 1982- which the Section can reach out to its ent. 1983: Undergraduate research, members and to the community. With Statement: The Treasurer chairs Department of Chemistry, College of respect to the first area, I can cite many the Budget Committee, is responsible St. Benedict, St. Joseph, Minnesota. years of experience at multiple levels for all Section funds except those of Research: My original research area is of administrative work, from commit- the Trust Accounts, and prepares physical organic chemistry. I still tees to collegiate Senate to department reports for the Board of Directors, maintain a “wet” lab and am currently chair, to my current position as Direc - National ACS, and state and federal studying the synthesis and charge- tor of Undergraduate Education. I have agencies. Audited financial statements transfer behaviors of a series of related worked with small and large groups of are prepared by a CPA. The Section dibridged cyclophane molecules. But currently operates with a budget of over the past ten years or so, I have people, many of whom held wildly dis- $265,000 of which 30% comes from spent more and more time in the areas parate opinions on the task at hand, Trust Funds, 35% from local and of chemical education and the use of and have always managed to accom- national dues, and 35% from program technology. I also spent my most plish what needed to be done in an revenues. About 25% of all expendi- recent sabbatical acting as an elemen- efficient and collegial manner. I feel tary and middle-school science teacher, that these skills will be invaluable in tures are related to awards which rec- which definitely put my creative and the event that I am elected to the ognize achievements in chemistry at organizational skills to the test. NESACS Board Chairmanship. all levels, from high school students to ACS Service: Member of ACS New and exciting areas of outreach professional chemists, including pro- are always difficult to identify, but grams that encourage young people to

14 The Nucleus May 2006 enter the profession. Administrative Humanitarian of the Year Award from expenses constitute 10% of expendi- the American Chiropractic Association Councilor / tures. The remaining 65% supports in 2000 as well as an honorary degree Alternate Councilor services to the membership such as the from the National University of Health NUCLEUS, monthly meetings, sym- Sciences in 2002. Eva Binnun posia, continuing education activities, Statement: It has been almost two Education: Boston University, professional relations services includ- decades that I have been serving as B.A. Chemistry, 2002; Northeastern ing employment services, and public Auditor for the Northeastern Section of University, currently pursuing M.S. relations activities such as National the ACS and to have maintained the Chemistry, part-time program Chemistry Week. The quality of these standards of accounting that should be Professional Experience: Johnson programs is high, and the major budg - but are unfortunately not always uni- & Johnson, PRD, Research Associate, etary problems involve setting priori- versally followed in today’s corporate 2002-2003; Wyeth Research, Scientist ties among them. I am pleased to work environment. It has been a particular I, 2003-present with the members of the Board of source of satisfaction to have wit- Statement: I am very honored to Directors who volunteer many hours in nessed the growth of the Society over have been nominated for the position the service of their profession. the past 20 years. of NESACS councilor. As a relatively It will be my pleasure to new member of the industry commu- extend my record of providing accu- nity, I am very excited to begin ef forts rate and uncompromising service for toward expanding the newly founded AUDITOR the coming term. Northeastern Section of the WCC, organizing new events, as well as Anthony Rosner actively recruiting new members from Anthony Rosner has been Director both industry and academia. Secondly, of Research and Education at FCER TRUSTEE I would take initiative in helping to for the past 14 years, blending a large increase students’ interest in chemistry variety of tasks distilled from a multi- Joseph A. Lima at the undergraduate college level faceted background in basic research Education: B.S. New Bedford through organization of job fairs and in biochemistry, clinical chemistry lab- Institute of Technology (1962); MBA, recruitment at both local and national oratory direction at a teaching hospital Babson College (1975) ACS meetings. I ask for your support of Harvard, grants administration, Professional Experience: Current and would be proud to serve as coun- teaching, journalism, and minority Career Position—Vice President, Tech- cilor for our section. research program development. After nical and Operations for Houghton obtaining his Ph.D. in Medical Sci- Chemical Corporation, Allston, MA. ences at Harvard in 1972 and conduct - NESACS Service: I’ve been a Edward J. Brush ing postdoctoral research at the NIH in member of ACS since student affiliate Education: Ph.D., Pennsylvania Bethesda and at the CNRS in Gif-sur- days. My major involvements with the State University (1984); B.Sc., King’s Yvette, France, in 1973 and 1974, he Northeastern Section have been with College, PA (1978) directed research and clinical chem- the Board of Publications for The Professional Experience: Associ- istry laboratories at Boston’s Beth Nucleus and currently as an NESACS ate Professor of Chemistry Bridgewa- Israel Hospital, then taught chemistry Trustee and member of the Esselen ter State College (1998-present, Chair and served as Department Administra- Award Committee. Additionally, I’ve 2006-present), co-coordinator of the tor in Chemistry at Brandeis Univer- served on a number of ad hoc commit - BSC Adrian Tinsley Program for sity and managed reseach operations in tees. Undergraduate Research (2000-2005), neonatology at Children’s Hospital in Statement: Our section is fortunate coordinator of the BSC Chemistry Boston until he joined FCER. He to have endowment funds available to Outreach Program (1999-present); chaired one of six charter committees support our many worthwhile activi- Clark University Visiting Professor at the inception of the National Center ties. These activities benefit both our (1996-1998); Kutztown University for Complementary and Alternative members and the “chemical commu- (1995-1996); Tufts University (1988- Medicine in 1992 and has served on nity” in general. If re-elected as a 1995); Postdoctoral Research Associ- the editorial board of three peer - Trustee, I will continue to work with ate University of Maryland reviewed journals, authoring papers the other Trustees to ensure our funds (1984-1988). reviewing chiropractic research, cri- are invested conservatively, managed NESACS Service: BSC student tiquing many recent publications of wisely and used responsibly. May I affiliate co-advisor (1999-present, questionable research design, and have your vote? Honorable mention awards 2001-pres- exploring the role of homocysteine in ent, Green Chemistry affiliate 2003, provoking spontaneous vertebral artery 2005); currently developing a database dissection. He is the recipient of the of student affiliate groups in the north-

The Nucleus May 2006 15 eastern section; NESACS Earth Day Revet/Microbac Laboratories, Inc. Section’s influence on National ACS event coordinator; co-coordinator of –Consultant (Part time); 2001–Present, policy decisions, increase interactions the NESACS-sponsored Northeastern Wellesley College, Chem. Dept., between our Section and the National Undergraduate Environmental Research Associate (Part time) Society, and increase the involvement Research Symposium at Bridgewater Member of ACS since 1976 of the membership in its activities. If State College (2002-present). ACS Service: 2000 – present, elected, I shall continue to devote my Memberships: American Chemical Member of the Council Committee on time and energy for the good of our Society (Divisions: Chemical Educa- Admission; 1998 – 1999, Associate members. I would truly be honored tion, Organic, Biochemistry, Environ- Member of the Council Committee on and grateful to receive your support mental), Council on Undergraduate Admission; 1995 – present, Associate and your vote so that I may continue to Research, American Association for Member of the International Activities serve you as a Councilor. the Advancement of Science, Ameri- Committee; 1994, Member of the Eco - can Society for Biochemistry and Mol- nomic and Professional Affairs Com- Mukund S. Chorghade ecular Biology. mittee; 1989 – 1993, Member of the Education: B.Sc. 1971; M. Sc. Honors: The V. James DiNardo Economic Status Committee; 1988, 1973 (1st Class Honors) University of Award for Excellence in Teaching at Associate member of the Economic Poona, India; Ph.D. (Organic Chem- Bridgewater State College (2004); Status Committee; 1987 -1988, Associ- istry), 1982, Georgetown University American Cancer Society Postdoctoral ate member of the Public Relations Professional Experience: Research Fellowship (1986-1987). Committee. Fellow, National Chemical Laboratory Statement: It is a privilege to be NESACS Service: 1984 – present, (1973-74); Instructor, Georgetown nominated to serve as NESACS Coun- Member of the Board of Directors University (1981-82); Postdoctoral cilor. As a 29-year member of ACS I NESACS; 1987 - present:, Councilor Research Assoc., University of Vir- have focused on providing research of NESACS (except 2003: Alternate ginia (1982-84); Postdoctoral Research experiences and other professional Councilor); 2001 - present: Chair of Fellow, Harvard University (1984-85); opportunities for undergraduate stu- the Membership Committee; 1999 – Senior Research Chemist (1985-89); dents, and look forward to bringing 2000, Chair of International Chemistry Project Leader (1989-90), Dow Chem- these skills to the northeastern section. Celebration for Y2K (NES); 1988 – ical Co.; Research Scientist/Assistant I would like to see an increased 1998, Member of the Professional Director, College de France, Paris and involvement of and collaboration Relations Committee; 1998, Worked Universite Louis Pasteur (1990-91); between the regional student affiliates for National Meeting & Centennial Project Manager, Abbott Laboratories, (undergraduate and graduate students) Celebration in Boston; 1997, Recipient Pharmaceutical Research (1991-95); in sectional activities, particularly out- of Henry A. Hill Award; 1988 &1995, Senior Director, Chemical Sciences reach to K-12 students and teachers. I Member of the Nominating Commit- Research & Development, CytoMed, will also work to expand on the tee; 1982 – 1992, Served on and Inc. (1997-98); President, CP Consult- already strong undergraduate research Chaired the Summerthing/Fallfest ing, Chorghade Enterprises (1995 to base in the section, with added oppor- Committee; 1990, Member of the present); Visiting Scholar University of tunities for summer research experi- Organizing and Planning Committee British Columbia, University of ences and conference travel. Finally, I for the ACS National Meeting in Chicago, Northwestern University and will strive to have the section take a Boston, also served as Public Relations others; Vice President, Pharmaceutical more active role in promoting green Chairperson; 1988, Chair of the Pub- Development Sciences, Geltex Phar- and sustainable chemistry in education, lic Relations Committee; 1984 – 1987, maceuticals / Genzyme , (2000 to teaching and research. As councilor I Chair of the Hospitality Committee, 2003); President and Chief Scientific look forward to the challenge of repre - including the IUPAC Meeting in Officer, Pharmaceutical Sciences Divi- senting the interests and concerns of Boston. sion, D & P Pharmachem (2003-pres- the students, educators, academic and Statement: I have a strong sense of ent). industrial chemists of the Northeastern enthusiasm for the activities of the ACS Service: Member since 1982. section. Northeastern Section and for the Chairman, Brazosport Section (1990); American Chemical Society. Because Organic Division, member; Chairman, Michaeline F. Chen I serve on both the Admissions and Symposium on Industrial Chem., Great Education: Clarke College, B.A.; International Activities Committees at Lakes Regional Meeting, May, 1997; Boston College, M.S. the National ACS, and am Chair of the Visiting Speakers Program (1999 to Professional Experience: Membership Committee of the Local present); Department of Career Ser- 1985–1997, US Army Research Labo- Section, I am able to represent the vices Consultant (2000 to present); ratory –Materials Directory, Chemist, local section at the national level in a Member, International Activities Com- Associate Primary Investigator , unique manner. If elected, I would mittee (2003-present) (Retired); 1998 – 2002, continue to broaden the Northeastern NESACS Service: Board of Direc-

16 The Nucleus May 2006 tors (1997-), Public Services Commit- Enterprise in the USA and the ACS are member of the newly-formed Ethics tee, Chair; Professional Services Com- complex and demand creative solu- Committee. She has completed many mittee, member and chair (2005-); tions. I will spare no effort in ensuring tours for the ACS Speakers Bureau. Public Affairs Committee; Public Rela- that the voice of our electorate is heard She served as President of the Ameri- tions Committee, Interim Editor (The and that the council determines effec- can Society for Mass Spectrometry Nucleus (2004) tive policies for all our members. (2002-4), is presently a member of Memberships, Honors: Maharashtra Moreover, I will bring the benefits of the Council of the Human Proteome Academy of Sciences (Elected Fel- membership to the members by partici- Organization, the Board of the Human low); Andhra Pradesh Academy of Sci- pating and initiating creative programs. Glycoproteomics Initiative and the US ences (Elected Fellow) IUPAC; Royal National Committee of IUPAC. She is Society of Chemistry (Elected Fellow); Catherine E. Costello a member of AAAS and the Society New York Academy of Sciences; Education: A.B. (Chemistry), for Glycobiology, and serves on NIH American Institute of Chemists Emmanuel College; M.S. and Ph.D. review panels and several editorial and (Elected Fellow); AAAS; Sigma Xi; (Organic Chemistry), Georgetown advisory boards. She is the author or Indian Society of Bio-Or ganic University coauthor of about 230 scientific Chemists; IUPAC Commission on Professional Experience: Boston papers. Biotechnology, Medicinal Chemistry, Univ. School of Medicine, is Prof. of NESACS Service: She currently New Technologies and Special Topics, Biochemistry and Biophysics and chairs the NESACS Constitution and Titular member, Division of Chemistry Founding Director of the BUSM Mass Bylaws Committee. She was a member th and Human Health; 20 IUPAC Con- Spectrometry Resource and the Car- of the NESACS Publications Commit- ference on the Chemistry of Natural diovascular Proteomics Center; Asso- tee (1988-1993) and its chair (1990, Products, Chicago, 1996; Chair, Scien- ciate Director of the MIT MS Resource 1993) and has served five terms on the tific Programs Comm., on Advisory (1975-1995). Nominating Committee Board for Organic Process Research ACS and Other National Service: Statement: I wish to continue to and Development, Chimica Oggi; At the national level, she is a Coun- serve as a Councilor for the Northeast - Member, Committees on Advanced cilor for the Northeastern Section ern Section in order to keep the inter- Professional Thinking, International (1989-present; Alt., 1986-8), has ests of our members before the Activities and Technology, American served as a member (1996-2005) and National ACS, to provide input to Institute of Chemists. Reviewer of chair (2004-2005) of the International national policies based on my experi- manuscripts for numerous leading pro- Activities Committee and is currently a ence with educational institutions, fessional journals. Awarded “Diamond Jubilee Fellowship”, Univ. Dept. of Chemical Technology, Mumbai, India; Awarded “B.D. Tilak Distinguished Visiting Fellowship”, Awarded “Bharat Gourav” Award, Government of India. “Alkyl Amines Padma Bhushan Prof. B.D. Tilak Chemcon 2002 Distin- guished Speaker Award” Listed in American Men and Women of Science, Who’s Who in Science and Engineer- ing Actively involved with Indian Cul- tural Coordination Committee, Washington, D. C. Leadership roles in several community groups. Invited speaker at numerous international con- ferences. Statement: It is a singular honor and privilege to have been nominated to the position of Councilor / Alternate Councilor for the Northeastern Sec- tion. It will be my endeavor to ef fectively represent the Northeastern section effectively in the National Council. The issues confronting the Chemical

The Nucleus May 2006 17 research funding programs and School, Newton. Head Sailing Coach; mers, Nanoparticles, and Composite national and international exchange of Brookline H.S. (1972-1998); Com- Materials in Nanoscience” Sympo- scientists and information, and to monwealth School (1992-); Winsor sium, PMSE/POLY divisions, Ameri- increase access of our members to the School (2000-). can Chemical Society Annual Meeting, wide resources available to support ACS Service: Member since 1955. Atlanta, GA, March 2006. their work and careers. Although our TV: Chemistry and Life Mechanisms, NESACS Service: NESACS mem- research often straddles a wide range WHDH-TV, Ch. 5, Boston; ACS ber since 2001. of activities, it is important that the Speakers Bureau: Tours to New York Other Service: Proposal Study ACS remain a central feature in our (1980), North Central (1986), Gulf Panel, The Molecular Foundry at professional lives and in those of our Coast (1987), Lake Lands (1988), Pal- Berkeley Lab (DOE), August 2005 – students and colleagues. I strongly sup- metto (1990), Mid-South (1995), present; Co-organizer, Annual Materi- port collaborations among academic Ozark (1999), Mid-West (2000), Car- als Symposium, Dartmouth Nanomate- institutions and between academia and olina (2002). rials Research Group, November 2004; industry and will continue to encour- NESACS Service: ACS Task Force Co-organizer, New England Polymer age interdisciplinary research and on Education, Chair, Chemistry Educa- Chemistry Workshop, 2003-2004. training and to highlight new opportu- tion Committee; Chair, Summerthing; Relevant Memberships: ACS nities for chemists in diverse areas of Chair, Northeastern Section (1981). member since 1993 (POLY, PMSE, work and study, at all stages of their Honors: General Electric Science ORG, COLL divisions); American education and careers. Fellow (1956); Lyman Newell Award Physical Society since 2000. (1962); Northeast U.S. Regional Honors: NSF Career Award Angeles Dios Award (1972); James B. Conant Award (2003); Research Corporation, Education: Ph.D., Graduate school (1974); John A. Timm Award (1981); Research Innovation Award (2002); of the City University of NY (1999); Mass Science Teacher Presidential 3M Non-tenured Faculty Award (2002- M.A., City University of NY (1994); Nominee (1985); Norfolk County 2004). B.S., Santiago de Compostela Univer- Honor Award (1986); Mass Teachers Statement: I would be honored to sity (1990) Assn. Award (1988); Aula Landis serve the Northeastern Section as a Profesional Experience: Genzyme Award (1989); Henry A. Hill Award councilor and will do my best to com - Corp., (2000-Present); Post-Doctoral (1989); Theodore W. Richards Award municate the needs and concerns of Associate, Picower Institute of NY, (1994). section members to the ACS. I also (1999-2000). Statement: On the local level, we hope to facilitate more extensive inter - ACS Service: Founding member should encourage member participa- action between chemists in the greater and first president of the Younger tion in monthly meetings and increase Northeastern region and the vibrant Chemist Committee of the NY local involvement by our membership on academic and industrial scientific com- section of the ACS. section committees to provide munity in the Boston area. Such inter - Statement: I am excited to be nom- improved member services. On the actions would ideally spur new efforts inated for the position of national level, we should use our sec- in educational outreach to the greater councilor/alternate councilor for the tion’s tremendous potential to influ- populace of the Northeastern region. Northeastern Section. If elected, I will ence ACS policy and activities. endeavor to represent the Northeastern Michael Hurrey section effectively in the National Robert B. (Barney) Grubbs Education: University of Central Council and will help ensure that all of Education: B. A., Pomona College Florida, B.S., 1998; University of our members are served by the Society (1993); M. S., Ph. D., Cornell Univer- North Carolina – Chapel Hill, Ph.D., and considered in its policies. sity (1995, 1998). 2004 Professional Experience: Assistant Professional Experience: Vertex Wallace J. Gleekman Professor, Department of Chemistry, Pharmaceuticals, Scientist I, Physical Education: Bridgewater State Col- Dartmouth College (2001-present); Sciences & Pharmaceutical Research, lege, B.S. (1951); Boston University, Post-doctoral researcher, Department 2006-Present; Scientist I, Analytical Ed.M. (1952); Walden University, of Chemical Engineering and Materials Development, 2004-05 Ph.D. (1982). Science, University of Minnesota ACS Service: Younger Chemists Professional Experience: Science (1998-2001); Exchange Scholar , Committee (voting), 2004-Present, Teacher (chemistry, physics, biology, Department of Chemistry, University Strategic Planning Subcommittee oceanography); Wrentham H. S., King of California, Berkeley (1997-1998). Chair, 2005-Present; YCC Liaison to Phillip R.H.S., Brookline H.S. Retired Research Interests: Polymer syn- Membership Affairs Committee, 2004- 1995. Adjunct at Emerson College, thesis; block copolymers, free radical Present. New England Section: cham- Suffolk University. Current: Instruc- polymerization. pion 1st annual golf tournament; North tional Support Staff, Oak Hill Middle ACS Service: Co-organizer, “Poly- Carolina Section:, presenter NC State

18 The Nucleus May 2006 Fair 2001-04 89), Professor (1989-), Chair, Depart- the continued development of educa- Memberships and Honors: ACS ment of Chemistry, (1999-). University tional programs for students at both the Member since 1999; ACS Division: of Virginia: Post Doctoral Research graduate and undergraduate level both Analytical Chemistry; Team VOCAP Associate (1974-75). Los Alamos Sci- locally and nationally and encourage Award (2006); James T. Dobbins Fel- entific Laboratory: AWU Pre-Doctoral further development of the student- lowship (2003-04); RICHES Award of Research Associate (1973-74), High mentor relationship. Excellence (2003); GAANN Fellow- School Chemistry/Physics Teacher ship (2002-03) (1964-70, 1975-78). American Insti- Patricia Ann Mabrouk Position Statement: As an active tute of Chemists (AIC-Board of Direc- Education: B.A. 1982 Wellesley; national member of the ACS, I believe tors 1999-01): (New England Institute Ph.D. 1988 Massachusetts Institute of that it is important to remain focused of Chemists, NEIC, Treasurer, 1988-). Technology on local section needs and concerns. Over 100 papers in chemical research Professional Experience: NIH Being a Younger Chemist, I find it journals. Postdoctoral Fellowship 1988-1900 equally important to express the view- Research and Interests: Physical- Stanford University; Assistant Profes- points of chemists who are just starting Inorganic Chemistry; Synthesis and X- sor, Northeastern University (1990- in their careers. It is just as important, ray crystallography of laser dye 1997); Associate Professor, however, to represent areas of concern molecules and transition metal Northeastern University (1997-2004); from Women Chemists, Senior thiosemicarbazones. Co-developer of a Professor, Northeastern University Chemists, Chemist with Disabilities, or web-based tutorial entitled “Symmetry (2004-present) any chemist who wishes to express and Space Groups”. Introduction of ACS Service: Member since 1988. their opinion to the National ACS. I Process Oriented Guided Inquiry Associate member of ACS SEED have been fortunate to serve my fellow Learning (POGIL) techniques into the National Committee (2003 – 2004); chemists at the national level for two chemistry curriculum. Associate member of Women years and would like to continue in ACS Service: Member since 1970. Chemists Committee (2006); panelist that role while expanding into new Member of INOR division. Nominat- for ANYL Kolthoff Awards (2004 – areas of the society. I enjoyed being ing Committee (2000-01). present); panelist for ANYL Giddings active in my past local section and Memberships and Honors: Amer- Award (2005) have been looking for an opportunity ican Crystallography Association NESACS Service: ACS SEED to serve NESACS. I believe that Coun- (ACA), New England Institute of Coordinator for NESACS (1998-pres- cilor is one of the highest honors that Chemists (NEIC), Council for Under- ent); Member of the Theodore William can be bestowed on a local section graduate Research (CUR), New Eng- Richards ACS Medal Award Commit- member, as it gives a community a land Association of Chemistry tee (1999 – present); Chair of chance to influence policy and con- Teachers (NEACT); 1st Recipient of Theodore William Richards ACS cerns of the society at large. I would the Keene State College Award for Medal Award Committee (2000 – like to serve NESACS as a Councilor Faculty Distinction in Research and 2004); Councilor (2004-present); so that I could feel like I’m giving Scholarship (2001). Chair-Elect (2005); Chair (2006) back to my fellow local chemists. I Statement: Since joining the ACS Memberships, Honors: NSF would like to implore all members of in 1970, I have had only limited oppor- CAREER Award (1996-2001); CASE NESACS to contact me with their tunity to serve while enjoying the Massachusetts Professor of the Year thoughts and wishes when it comes to many benefits offered. My experience (2003); Northeastern University Excel- the society so that when deciding on at the undergraduate level in both lence in Teaching Award (2004); matters important to the local section, I teaching and research should serve as a Sigma Xi; AAAS; NSTA; CUR; will be able to represent everyone to catalyst and refreshing viewpoint to Coblentz Society; SAS; AAUP; the best of my abilities. Please con- the continued development of chemical NEACT; SBIC sider me for Councilor so that I may be education, one of this section’s most Statement: First, let me express my your voice at the national meeting. important assets. I would hope to sincere thanks to all of you! I am bring my expertise in this area to the extremely grateful for the opportunities Jerry P. Jasinski section and be an advocate of pro- I have had as one of your representa- Education: B.A., M.S.T., Univer- grams that promote and bring excite- tives on the Council over the past two sity of New Hampshire (1964, 1968); ment to science and chemistry to years. I deeply value the opportunity M.N.S., Worcester Polytechnic Insti- young people as well as recognize the this position has afforded me to “give tute (1968); Ph.D., University of achievements of both graduate and something back” and the doors it has Wyoming (1974); undergraduate students in the chemical opened for me on so many levels. As Professional Experience: Keene sciences within the Northeastern Sec- one of your elected councilors, I have State College: Assistant Professor tion of the American Chemical Society. had the opportunity to serve on a (1978-83), Associate Professor (1983- I would be a positive spokesman for national level with ACS SEED Com-

The Nucleus May 2006 19 mittee and now with the Women istry, Division of Chemical Education; Chemists Committee and its advocacy American Association for the Dorothy J. Phillips subcommittee. I feel that I am just get- Advancement of Science; Sigma Xi; Education: Vanderbilt University, ting started and I am eager to continue Phi Beta Kappa; Project Kaleidoscope, B.A., 1967; University of Cincinnati, and deepen my involvement in Faculty for the 21st Century Ph.D., 1974. National ACS and the WCC over the ACS/NESACS Service: Councilor Professional Experience: (past 10 next several years. Of course I can 1999 - 2002, 2004 - 2007; Membership years): Waters Corporation, 1984 to only do this with your support so I am Committee 2000-01 date; Director, Clinical Marketing, asking for your vote for the position of Statement: I have greatly enjoyed 2004; Director, New Business Devel- Councilor. my service thus far as a Councilor rep - opment, 2003-04, Director, Strategic resenting NESACS. At local and Program Management, 2000-02; Brand Julia H. Miwa national meetings, I and my fellow Manager, 1997-99; R&D Laboratory Education: Massachusetts Institute NESACS Councilors have had met Manager, 1986-96. of Technology, Cambridge, MA, 1987- with national officials and voted on Service in ACS National Offices: 1992; Ph.D. in Chemistry, June, 1992. matters of importance to both local Committee on Committees, 2001-06, Thesis title: Synthesis and sections and the national membership Secretary 2003-04, Chair of Industrial Conformational Studies of the ß-Amy- of ACS. If elected to another term, I Pipeline Sub-Committee 2005-06; loid Protein of Alzheimer’s Disease; hope to continue put this experience to Committee on Membership Affairs, HAVERFORD COLLEGE, Haverford, work on behalf of the Northeastern 1997-00, Committee Associate, 1996; PA, 1981-1985, B. A., May, 1985. Section. Committee on International Activities, Graduated magna cum laude with High My particular areas of interest are Committee Associate, 1998. Honors in Chemistry; Senior Research (a) chemical education and the issues Service in NESACS Of fices: Project: Determination of exchange facing academic chemists (job security Member ACS since 1973. Northeast- rate constants using two-dimensional issues, ACS curricula, and K-12 ern Section: Councilor, 1995-2006; NMR spectroscopy. teacher training are a few of the hot Chair, 1993; Chair-Elect and Program Professional Experience: Associ- issues in this area) and (b) the status of Chair, 1992; Project SEED, Committee ate Professor (Sept. 2002 - present) chemical professionals and of chem- Chair, 1994-95; Nominating Commit- Assistant Professor (Sept. 1994-August istry as a discipline (outreach activities tee, Chair, 1994; Co-chair Centennial 2002): Department of Chemistry, and communication with legislators Celebration, 1998; Chair, Fundraising Wellesley College; Research Area: fall under this heading). If elected, I Committee, 2004-06. Synthesis and Conformational Studies would seek to work with Council Memberships: The American Soci- of Peptide Analogs with Backbone Committees that address these particu- ety of Mass Spectrometry (ASMS); Modifications Teaching Areas: Organic lar issues. American Association of Pharmaceuti- Chemistry, Introductory Chemistry; ACS serves a diverse group of cal Scientists (AAPS); National Orga- Visiting Scientist: Whitehead Institute chemical professionals. The member- nization for the Professional for Biomedical Research (June 1997- ship includes male and female profes- Advancement of Black Chemists and June 2001); Laboratory of Dr. Peter S. sionals of varying ages, races, Chemical Engineers (NOBCChE); Kim. Synthesis and Evaluation of educational levels, and professional American Association of Clinical Thioxo Peptide Analogs of the GCN4 interests. For the most part, ACS Chemists (AACC); ACS Divisions: Leucine Zipper Helix; NIH Postdoc- Council does not reflect this diversity. Agrochemicals; Analytical Chemistry; toral Fellow: University of California, The NESACS delegation reflects the and Biological Chemistry. Berkeley (July 1992 - June 1994); Lab- diversity of the ACS membership bet- Honors: Sigma Xi; Distinguished oratory of Professor Paul A. Bartlett. ter than most, and this is a direct result Alumni, University of Cincinnati, Design, synthesis, and evaluation of of the efforts of our leaders to encour- awarded by both McMickens College inhibitors of HIV-1 protease. Synthesis age participation from all members of of Arts and Sciences and Department of a combinatorial library of phosphi- NESACS. There are many qualified of Women Studies; Waters’ Manager nate inhibitors of thermolysin. candidates on this year’s ballot, and all Award for Innovation, 1987 and 1988; Honors and Awards: Pinanski will represent NESACS well. I hope Honored by TTT Mentor Program of Prize for Excellence in Teaching, the voters will do as they have done in Cambridge, MA as a Minority Role Wellesley College, June 1997; Camille the past and select a varied slate of Model, 2004-05, “Minority Role Mod- and Henry Dreyfus Faculty Start-up Councilors to represent NESACS. I els in Science, Mathematics, Technol- Grant for Undergraduate Institutions would be pleased to serve again as ogy and Engineering - A Traveling National Institutes of Health Postdoc- Councilor of the NESACS and to share Photo Exhibit”. toral Fellowship, awarded June 1992. my experience with any new Coun- Related Activities: Dow Chemical Memberships: American Chemical cilors elected this time. Company, 1974-84; Delegate with the Society: Division of Organic Chem- People to People Ambassador Program to China in 1990 with a group of scien-

20 The Nucleus May 2006 tists for technology transfer; Member Committees; in this position my focus of AAPS Delegation to China in 2004 has been on increasing the involve- Marietta Schwartz to explore academic and industrial col - ment of industrial chemists in the gov - (For biographical information see laborations in the pharmaceutical sci- ernance of the Society . The above under Chair-Elect) ences; Established Waters’ sponsorship Sub-Committee that I chair worked Statement: The role of the coun- of the Distinguished Service Award in with ACS staff to design a website cilors is an important one to the sec- Analytical Chemistry given by the with testimonies of industry chemists tion, as they represent the section to Division of Analytical Chemistry; Part- involved in Society governance as an the larger society and communicate ners in Mathematics and Science Com- incentive to their colleagues to also national decisions back to the local mittee of Alpha Kappa Alpha Sorority serve. section. Policy and communication are Incorporated, coordinating the North- If given the opportunity to con- two areas that I deal with on a daily eastern Section’s sponsorship of pro- tinue as a Councilor, I will use my basis in my current administrative grams that focus on increasing the unique set of skills developed through position, and I would be honored to math and science interest of minority leadership roles in industry and in the have the opportunity to utilize those students in greater Boston; Mentor for Society to strengthen the programs and skills to serve NESACS. the New England Board of Higher operation of NESACS. I will focus on Education (NEBHE) Science Network supporting the inclusiveness of pro- Amy E. Tapper for students who are traditionally grams in the Section in my next three- Education: B.S.Chemistry, Boston underrepresented in Science, Technol- year term. My work with the Society College; Ph.D. Chemistry, Boston Uni- ogy, Engineering and Mathematics will support its 2006 vision field and versity (STEM); papers presented at PittCon, developing strategic plan to help both Professional Experience: Aquatec, International Symposium on Column academic and industrial chemists Inc., Colchester, VT (1994-95); Wyeth- Liquid Chromatography (HPLC Sym- advance their careers and become lead- Ayerst Pharmaceuticals, Rouses Point, posiums) and at the national meetings ers of the chemical enterprise. NY (1995); Senior Scientist, Genzyme of ACS, AAPS and ASMS. Approxi- I ask you to support my serving as Drug Discovery and Development, mately 70 publications and presenta- Councilor of NESACS. I will accept Waltham, MA (2001 –2004), Associate tions in the field of analytical my responsibility as a Councilor to Director, Peptimmune (2004-present) chemistry with a focus on HPLC. bring to reality a stronger Section and ACS Service: Member 1995 – pres- Statement: The 2006 President of a better and more effective American ent, International Activities Commit- the American Chemical Society, Dr. Chemical Society. tee, Associate (2004-2006), Councilor Ann Nalley, stated “Service as an ACS councilor is a significant responsibil- ity”. I have accepted that responsibility as a Councilor of the Northeastern Sec- tion of the American Chemical Society (NESACS). I wish to continue to serve as a Councilor of NESACS; as a member from industry I help NESACS’s initiatives to be inclusive, addressing both industrial and aca- demic scientists and scientific matters. I also want to continue in order to help the Society develop and implement its strategic plan for 2007-2009. The past three-years as Councilor has been enlightening and rewarding, giving me an opportunity to make con - tributions to NESACS as well as to the Society at the national level. Impor- tant to a non-profit organization is fund-raising. After becoming chair of NESACS’s Corporate Fundraising committee, the biannual vendor fair was initiated successfully in 2004; the second fair is being planned for 2006. As a NESACS Councilor I was elected to the ACS Council Committee on

The Nucleus May 2006 21 (2003 –06), Boston National ACS participation of younger chemists both ing advances and changes in the world Meeting Committee, 2002, Recipient from academia and industry as well as of Chemistry. of a 2002 ACS YCC Leadership increase our industrial participation as In a different vein, I firmly believe Development Award a whole. As a Councilor, one is that the problems facing the chemical NESACS Service: Chair-elect encouraged to interact with the mem- profession, and its practitioners, are 2004, Chair 2005, Immediate Past bers of our local section as well as more numerous and profound than at Chair 2006; Chair NESACS Golf members of our National Society. This any previous time in the history of the Tournament 2005, 2006; Younger enables the exchange of ideas for net- science. But so too are the opportuni- Chemists Committee working and programming for the bet- ties for Chemistry to contribute to the (NESACSYCC)—Founding member, terment of our Section. I believe that health and welfare of society as a Co-chair (1999), Chair (2000-02), Co- my experience with the Section makes whole. We must do more to educate chair (2003); Chair Career Develop- me an appropriate candidate for Coun - our political leadership whose scientif- ment Committee, Chair , Social cilor. ically uninformed decisions often hin- Committee, Co-chair (1999-2003); der scientific progress in this nation. Coordinator of 2001-2003 YCC Career Alfred Viola We also must address the rampant sci- Workshops. Northeast Student Chem- Education: BA, MA, Johns Hop- entific illiteracy within the public at istry Research Conference (NSCRC) kins University; Ph.D., University of large. There is need for far greater Committee—Founding member, Co- Maryland. understanding of the truths and mis- chair and Speakers Officer (1999- Professional Experience: Boston conceptions which abound about the 2000); Chair 2001; Co-chair 2002. University, Research Associate, 1955- world of Chemistry. The world of Member of the steering committee for 57; Northeastern University, 1957-62 advertising is rampant with misstate- the exchange initiative between Asst. Prof., 1963-68 Assoc. Prof., Pro- ments regarding chemicals, or lack NESACS and the GDCh (2000 fessor 1968-97, Prof. Emeritus 1997- thereof, in individual products. Chem- –2006); YCC position on the NESACS present; Visiting Professor University istry has long been a positive force in board (2000-03); Nominating Commit- of Munich, Germany , 1977, and the welfare of society but the general tee (2001) Director-at-Large (2002); Monash University, Melbourne, Aus- public now perceives it otherwise. I Corporate Affiliates Committee tralia, 1984; Visiting Scholar, Welles- would like to see the A.C.S. address (2003). YCC ChemLuminary award ley College, 1992-present. this issue much more forcefully. received in 2000, 2001, 2002, 2003, Service to ACS and NESACS: I would appreciate your vote to 2004. Alternate Councilor 1963-68, Coun- provide me the opportunity to continue Other Related Professional Expe- cilor 1986-88, Alternate Councilor my activities on behalf of this Section rience/Service: Boston University 1990-97, Councilor 1998-2000, Alter- and to represent these views within the Younger Chemists Committee-Founder nate Councilor 2001- present; Norris Northeastern Section and the National and President (1999-2000); Chair, Award Selection Committee 1979-86 Council. Career Development Committee (Chair 1981 and 1985); Continuing (1999-2001); Co-chair, Social Com- Education Committee 1989-present, Denyce K. Wicht mittee (1999-2001); Member of the (Co-Chair 1989, Chair 1990-present); Education: B.A. (chemistry) with Graduate Student Organization of Nominating Committee 1998. honors, University of Vermont (1994); Boston University (1998-99); Student Statement: I was honored to receive Ph.D. (chemistry), Dartmouth College member of the Boston University the Henry A. Hill Award in 1996 for (1999). Chemistry Graduate Affairs Commit- Distinguished Service to the Northeast- Professional Experience: Assistant tee (2000-01). ern Section, but that does not entitle Professor of Chemistry, Suffolk Uni- Statement: One of the roles of a me to rest on my laurels. As Chair of versity (2005-present); Visiting Assis- Councilor is to represent the Section at the Continuing Education Committee I tant Professor of Chemistry, Wellesley National meetings. Over the past three have been responsible for bringing College (2003-2005); Staff Chemist, years during my chair term, I believe National ACS Short Courses to the General Electric Global Research Cen- that I have gained a much greater Section at a fraction of the tuition costs ter (2000-2002); Postdoctoral Associ- understanding of the strengths and normally associated with these pro- ate, Massachusetts Institute of needs of our Section. I continue to feel grams. Many of the cutting edge topics Technology (1999-2000). strongly that for the future of our local covered in such courses were not in ACS Service: Member since 1991. section, it is imperative that we have any curriculum for Chemists graduat- Statement: I am running for the younger chemists active on committees ing as recently as five years ago. I position of Councilor/Alternate Coun- and the NESACS board. Younger firmly believe this to be a vital activity cilor in order to progress my ACS affil- chemists can learn from the experience which the Section must undertake to iation to a more active role; one that of our members and bring new ideas to provide our membership the opportu- incorporates both leadership and serv- the section. We need to increase the nity to stay abreast of the ever evolv- ice. My aim is to begin my service

22 The Nucleus May 2006 with the Northeastern Section of our ACS Service: Member since 2001 1991. Director, Chemical Products professional society and I look forward NESACS Service: Younger Research, Development and Engineer- to facilitating communication between Chemists Committee Chair (2005- ing; GelTex Pharmaceuticals 1991- our local chemistry community and present), Assistant-Chair (2003-2005) 2000. Co-Founder and Vice President national officers of the ACS. Membership, Selected Honors: of Chemical Research, co-inventor of Tufts University Graduate Student Renagel® and WelChol®; Genzyme Research Award (2005), Tufts Univer- Corp 2000-2004. Sr. Vice President, sity Outstanding Academic Perfor- Chemical Research; Peptimmune, Inc. DIRECTOR-AT-LARGE mance Award (2004), 35th 2004-present. Vice President Process International Conference on Coordina- Chemistry and CMC. Cassandra Celatka tion Chemistry Poster Award (2002), Awards and Achievements: Amer- Education: B.A., Chemistry, North Award at 42nd Conference of Polish ican Chemical Society Award for Team Adams State College, 1994; Ph.D., Chemical Society(1999), National Innovation 2005’; Colorado School of Chemistry, Boston University, 2004. Academy of Sciences of Ukraine F. D. Mines Distinguished Achievement Professional Experience: Scientist, Ovcharenko fellowship (1999). Medal, 2004; Colorado School of Staff I, Genzyme Corp., Waltham, MA Statement: I’m honored to be nom- Mines Chemistry Department Visiting (2005-present); Sr. Scientist, inated for a position of director-at- Committee, 2003-2006; Colorado DAIAMED (formerly Suntory Phar- large for the Northeastern Section of School of Mines Distinguished Alumni maceutical Research Laboratories), the American Chemical Society. I have Lecturer, 2002; American Chemical Cambridge, MA (2002-2005). been involved in the local secion activ- Society, Northeast Region, Industrial ACS Service: Member (1995- pres- ities for several years first as an Assis- Innovation Award, 2001; National Kid- ent) tant Chair and then as a Chair of the ney Foundation of Northern California, NESACS Service: Northeastern Younger Chemists Committee (YCC). Champion of Hope Award, 2001; Section Younger Chemists Committee, Our goal is involve younger chemists American Chemical Society, Polymer NSYCC (1999-2003); Organizing in national and local ACS program in Chemistry Division, Award for Indus- Committee Northeast Student Chem- order to help with their transition into a trial Polymer Chemistry, 2000; R&D istry Research Conference (NSCRC) professional career. During past sev- 100 Award for Renagel (1999-2003); YCC Mentor for North- eral years YCC reached new level of Capsules.Awarded by R&D magazine, east Section Chemistry Career Fair organization. New activities, such as 1999; 88 publications and patents (2004); Member of the steering com- highly successful Career Fair were Statement: I have been a member mittee for the exchange initiative introduced and organization of our tra- of the ACS for 35 years and although I between NESACS and the GDCh ditional events was improved. Please have received much from the Society, I (2004). visit our website www.nsycc.org for have yet to give anything back. This Statement: Many younger chemists detailed reports. Hard work and devo- position is perhaps only a very small do not realize how their involvement tion of all YCC officers was reflected gesture in that direction, but is one that with a professional organization can in last year’s national ChemLuminary is important to me. I will be helping benefit their career development. This award. If elected I would try to get organize and run the 2nd Annual involvement is not just important for more students involved in participating NESACS Golf Tournament (the first younger chemists in the early stages of in the local section activities. I will was a major success with almost their careers but is equally important continue working within the local sec- $10,000 raised). My other priorities for chemists who have been involved tion to create opportunities for profes- will include increasing industrial par- with the organization for years. I see sional development of younger ticipation in the section’ s events an important role of the Director-at- chemists. through networking with my many Large to cultivate these relationships to industrial contacts. benefit the future of NESACS. W. Harry Mandeville Education: B.S., Colorado School Gary R. Weisman Ivan V. Korendovych of Mines, 1971; Ph.D., Massachusetts Education: Primary and secondary Education: B.S. (1999), M.S. Institute of Technology, 1975. education in public schools in Mason, (2000) Taras Shevchenko National Professional Experience: Hoff- Ohio; B.S. in Chemistry With Distinc- University of Kiev, Ph.D. (2006 mann-LaRoche, Nutley, NJ 1975-1985. tion, University of Kentucky, 1971 expected) Tufts University Process chemist in the Chemical (undergraduate research with Robert Professional Experience: Teach- Development department, Manager D. Guthrie); Ph.D. Organic Chemistry, ing and Research Fellow at Taras Kilo Lab; Hyperion Catalysis Interna- University of Wisconsin-Madison, Shevchenko National University of tional 1985-1987. Chemical Process 1976 (mentor: Stephen F. Nelsen). Kiev (1995-2000) and Tufts University Development; Waters Chromatogra- Professional Experience: Post-doc- (2001-2006) phy, Division of Millipore Corp. 1987- toral, University of California, Los

The Nucleus May 2006 23 Angeles, 1976-77 (mentor: Donald J. continue to serve as a Director-at- of Science, 1972-; American Chemical Cram); Faculty member of the Depart - Large of the NESACS if the members Society, 1978-; Quantum Chemistry ment of Chemistry, University of New choose that I do so. Naturally, I would Program Exchange, 1978-; Medicinal Hampshire since 1977, Professor of do my best to further the goals of the Chemistry Group of the Northeastern Chemistry since 1994; Visiting Associ- Society and represent the views of the Section of the American Chemical ate Professor, University of Wisconsin, members of the section, with special Society, 1978-; International QSAR 1986; Visiting Fellow, University of emphasis on the views of New Hamp- Society, 1993-;Society for Neuro- Bristol, England, 1987 and 1998; Visit- shire members. Two continuing goals science, 1994-, Boston Area Neuro- ing Professor, Australian National Uni- of my service are to increase the science, 1998-; Research Interests: versity, 2005; Visiting Professor, involvement of New Hampshire Molecular modeling using molecular University of Melbourne, Australia, chemists in section activities, and to mechanical and quantum mechanical 2005. promote participation in Northeast methods; conformational analysis Research Interests and Areas of Regional Meetings of the ACS. I using experimental and theoretical Expertise: Physical organic chemistry; believe that NERM’s are scientifically methods; and the design and synthesis Synthetic organic chemistry; Synthe- rewarding and wonderful opportunities of pharmacological compounds with sis, reactions, special properties and for involving chemists in Society dopamine and opioid activities. coordination chemistry of amines and activities early in their careers. About 60 publications and 6 issued polyamines and derivatives; Ligand patents design and synthesis; Biomedical ACS Service: Secretary-Treasurer, applications of coordination com- Medicinal Chemistry Group of the plexes; Supramolecular chemistry; NOMINATING COMMITTEE NESACS, 1981-82; Program Chair- Conformational analysis and molecular man, Medicinal Chemistry Group of modeling; Intramolecular interactions Mark Froimowitz the NESACS, 1990; Chairman, Medic- including transannular interactions; Education: B.S. Chemistry, Brook- inal Chemistry Group of the NESACS, Transacylation reactions; In/out iso- lyn College, 1968; Ph.D. Physical 1991. merism and homeomorphic isomeriza- Chemistry, New York University, tion of bicyclic molecules; Use of 1972. Thomas R. Gilbert NMR in structural and conformational Professional Experience: postdoc- Education: Clarkson College of analysis of or ganic and metallo- toral fellowship, Brandeis University, Technology, B.S., 1968; Massachu- organic compounds. 1972-73; postdoctoral fellowship, New etts Institute of Technology, Ph.D., ACS Service: Member since 1970. England Medical Center Hospitals, 1971 Co-Program Chair of NERM 2001, the 1973-74; applications analyst, Massa- Professional Experience: Current 30th Northeast Regional Meeting of the chusetts Institute of Technology, Cam- Positions Associate Professor of American Chemical Society, Durham, bridge, 1974-76; Instructor, University Chemistry and Education, Acting NH; Director-at-Large, NESACS, of Lowell, 1976-77; Assistant Bio- Dean, School of Education, Northeast- 2002-present. chemist, McLean Hospital, 1977-86; ern University NESACS Service: Richards Medal Research Associate in Psychiatry (Psy- Service in ACS (National): Committee 2004-present. chobiology), Harvard Medical School, Committee on Nominations and Memberships, Honors, Etc.: 1977-79; Instructor, Department of Elections, 2001-06, Vice-Chair, 2004- Sigma Xi - The Scientific Research Psychiatry (Psychobiology), Harvard 06, Chair of Task Force on Election Society of North America, 1976-pres- Medical School, 1979-87; Lecturer, Procedures, 2003-2005; Council Pol- ent; Excellence in Teaching Award, Department of Chemistry, Tufts Uni- icy Committee (Nonvoting), 2000; College of Engineering and Physical versity, 1986; Associate Biochemist, Committee on Meetings and Exposi- Sciences, University of New Hamp- McLean Hospital, Belmont, MA, tions, 1995-00, Chair, 2000, Com- shire, 1995; Wilsmore Fellow, Univer- 1987-93; Assistant Professor, Depart- mittee Associate, 1994, Education sity of Melbourne, Australia, ment of Psychiatry (Molecular Phar- Division, Examinations Institute, June-Aug, 2002; Elected Vice-Chair macology), Harvard Medical School, 2000 Analytical Chemistry Exami- (2003) and Chair (2005), Gordon 1988-93; Senior Scientist, Molecular nation Committee, 1998-00; (Divi- Research Conference on Physical Design, Pharm-Eco Laboratories, sional): 46th Annual Summer Organic Chemistry; Gloria G. and 1994-98; Scientific Fellow, Pharm-Eco Symposium on Analytical Chemistry, Robert E. Lyle Professorship, Depart- Laboratories, 1998-02; Research Co-Chair Organizing Committee, ment of Chemistry,University of New Professor of Chemistry, Massachusetts 1993. Hampshire, 2005-2009; Reviews Edi- College of Pharmacy and Health Sci- Service in NESACS (Northeastern tor, Journal of Physical Or ganic ences, 2002-. Section): Councilor, 1990-07; Alter- Chemistry, 2006-present. Memberships and Honors: Ameri- nate Councilor, 1987-89; Chair, 1988; Statement: I would be pleased to can Association for the Advancement Chair-Elect, 1987; Nominations

24 The Nucleus May 2006 Committee Chair, 1989; Long- ment of Chemistry, University of Chair, Education Committee Range Planning Committee, 1989; North Carolina at Charlotte (1994- (1993–96); Chair, College Subcommit- Analytical Group Chair, 1983-86; 2000). Prior to that he was a faculty tee, Education Committee (1997–pres- Northeast Regional Meeting: General member at New Jersey Institute of ent); Member, Centennial Committee Chair, 1993; Centennial Cele- Technology and Rutgers University (1997–99); Alternate Councilor bration Program Chair, 1998 and was a Councilor for the North Jer- (1994–97, 1999–2002); Councilor Honors: Outstanding Teacher of sey Section of ACS as well as Chair of (1997–98, 2003–present); Chair , First Year Students Award, College of the Organic Chemistry Division of the National Meeting Committee Engineering, Northeastern University, North Jersey Section of ACS. (2001–02); Chair–Elect, Chair, Imme- 2002; Excellence in Teaching Award, diate Past Chair (2001–03 Northeastern University, 1999; Sigma Relevant Memberships: American Xi; Gamma Sigma Epsilon. Chemical Society; American Associa- Statement: Having served NORRIS AWARD tion for the Advancement of Science; once as chair of the Nominations Com- COMMITTEE New England Association of Chem- mittee, I look forward to serving again istry Teachers; Sigma Xi as a member. Morton Z. Hoffman Honors: Phi Beta Kappa (1955); Education: A.B., Hunter Senior Postdoctoral Research Associ- Patrick M. Gordon College–City University of New York ate, U.S. National Academy of Sci- Education: B.Sc. University of (1955); M.S., University of Michigan ences (1969–70); Associate of the Guyana (1977); M.Sc, University of (1957); Ph.D., University of Michigan Danforth Foundation (1970); Alumni New South Wales, Australia (1982); (1960). Association Hall of Fame, Hunter Col - Ph.D., University of Manitoba, Canada Professional Experience: Postdoc- lege–City University of New York (1987) toral Research Associate, Sheffield (1977); Fellow of the American Asso- Professional Experience: Post University, England (1960–61); Boston ciation for the Advancement of Sci- Doctoral Associate, Kansas State Uni- University: Assistant Professor through ence (1992); Metcalf Cup and Prize for versity, (1987-1988); Organix Inc., Professor (1961–2005), Emeritus Excellence in Teaching, Boston Uni- Woburn, MA (1988-1991); Senior Sci- (2005–present); Visiting Scientist, U.S. versity (1994); Henry A. Hill Award entist; Polaroid Corporation (1991- Army Natick Laboratories (1969–74); for Outstanding Service, Northeastern 2001); Arqule Inc. (2001-2002); Director, Center for Teaching Excel- Section (1999); National Responsible Polymer Laboratories, (2003-2004); lence, College of Arts and Sciences, Care® Catalyst Award for Teaching Simmons College (2005 to Present). Boston University (1994–97); U.S. Excellence at Four–Year Colleges and ACS Service: Alternate Councilor National Representative, Committee Universities, American Chemistry (1994-1996, 1997-1999, 2000-2001, on Chemistry Education, International Council (2002); The John A. Timm 2003-2006) Union of Pure and Applied Chemistry Award for the Furtherance of the Study NESACS Service: NERM Chair of (2004-06). of Chemistry, New England Associa- the Symposium on Cannabinoids, Recent ACS Service: SOCED Task tion of Chemistry Teachers (2003); (1989); Centennial Committee Co- Force on Undergraduate Programming Arthur Sweeny, Jr., Memorial Lecturer, Chair (1998); Member, Board of Publi- (1991–2002); CHED Program Com- Lehman College–City University of cations 1999 to present; Secretary, mittee (1992–2004), Chair New York (2003); Leavey Family Lec- Board of Publications, 2000; Chair, (1999–2001); CHED International turer, St. Michael’s College, Vermont Board of Publications, 2002; Member, Activities Committee (1993–present); (2005); James Flack Norris Award for Board of Publications, 2003. College Chemistry Consultants Service Outstanding Teaching, Northeastern Statement: It would be a pleasure (1995–present), Advisory Board Section (2005); Alumni Association to serve on the Nominating Committee (2002-04); Editorial Advisory Board, Outstanding Professional Achievement of the NESACS. General Chemistry Project Award, Hunter College–City Univer- (1999–2004); Chair, CHED Regional sity of New York (2006). Arthur Greenberg Meetings Committee (2000–present); Education: Ph.D., Princeton Uni- Society Committee on Education Mary Jane Shultz versity, 1971 (2002–present); Organizing Commit- Education: B.S. with Honors, Professional Experience: An tee, Conference on Research and Edu- 1970, University of Wisconsin; 1970- organic chemist, he is Professor of cation in the Middle East 71, Kansas State University; Ph.D., Chemistry at the University of New (2002–present); Chair-Elect, Chair, 1975, Massachusetts Institute of Tech- Hampshire. He was Dean of Engi- Immediate Past Chair, Division of nology neering and Physical Sciences at the Chemical Education (2004–06). Professional Experience: Chair, University of New Hampshire (2000- Recent NESACS Service: Member, Department of Chemistry, Tufts Uni- 2005) and prior to that Chair, Depart- Board of Directors (1993–present); versity, 2000-to date; Professor, Tufts

The Nucleus May 2006 25 Candidates Riverside; PhD (1984), Chemistry, Massachusetts Institute of Technology. NEW Continued from page 25 Professional Experience: Assistant University, 1999-to date; Research Sci- Professor (1984-1990), Associate Pro- entist, Laser Spectroscopy Laboratory, fessor (1990-1996), Professor (1996- BASEBALL M.I.T., 1985-89; Associate Professor, present), Chair (2001-2004) of Minor League Doubleheader Tufts University, 1985-1999; Visiting Chemistry at Dartmouth College; at Fenway Park Professor, M.I.T., 1985-87; Assistant recent invited lectures: “Frontiers in Professor, Tufts University, 1979-85; Bioinorganic Chemistry” symposium A new baseball experiment is set for Research Fellow, Brandeis University, at the 82nd Canadian Society of Saturday, August 26, 2006 that takes 1979-80; Assistant Professor, Univer- Chemists Conference and Exhibition place at Fenway Park starting at 2:00 sity of Mass. Boston, 1978-79; (5/99), “Metal-Peptide Complexes” p.m. involving a double- header with Research Associate / Lec-turer, Boston symposium at the 221st National ACS the Lowell Spinners vs. the Oneonta College, 1977-78; Research Fellow, Meeting (4/01), 9th International Tigers followed by the Pawtucket Red Harvard University, 1976-77; Post Meeting on EPR Studies of Viable Sox vs. the Rochester Redwings. Doctoral Research Associate, Univer- Systems (9/01), Metals in Biology Prices have not been set but should be sity of California, Berkeley, 1975-76 Workshop at University of Southern about half the Red Sox prices. Tickets Honors and Awards: Chair, Visu- Denmark (9/01), 2003 Current Trends go on sale immediately and we shall alization in Science and Education in Microcalorimetry (7/03). order a bunch of tickets for NESACS International Conference, 2003; Out- Professional Service: member of members. Call or e-mail Wally Gleek- standing Faculty Award, Tufts Univer- ACS since 1978; member of NESACS man if you would like tickets. sity (Chemistry) 1999; National Nominating Committee 2000, 2001, To reserve tickets for the games Science Foundation Visiting Faculty, 2004; member of Sigma Xi since 1984, below, contact Wally Gleekman at M.I.T., 1984-85; National Science current President of the Dartmouth >gleekmanw(at)msn.com< of. 617- Foundation Visiting Professorship, Chapter; member of Society of Biolog- 527-1192. An 8 page info outline of teams, directions, parking, etc. is avail- 1985-86; Mellon Grant Faculty Devel- ical Inorganic Chemistry; member of ◆ opment Award Recipient, 1983; Tufts International EPR(ESR) Society; able on request. University Faculty Research Fellow, Board of Editors of Inorganic Chem- Summer, 1980; Brandeis University istry (1995, 1996); advisory committee Research Fellow, Summer, 1979; for EPR Center for the Study of Viable Summerthing 2006 Research Fellow, Division of Engi- Biological Systems, Dartmouth Med- Continued from page 7 neering and Applied Physics, 1976-77; ical School (1997-present); organizer (Fitton Field – Exit 11 off I290) Radcliffe Fellow, 1976-77; of “Coordination Chemistry of Metal Other Accomplishments: Author of Metabolism” symposium at the 224th New Hampshire Fisher Cats – AA text, Chemistry for Engineers: An National ACS meeting (8/02); organ- vs. Altoona Curve Applied Approach (Houghton Mifflin, izer of “Dartmouth Chemistry Sympo- Sunday, June 11, 1:05 pm Co., published 2006); sium” (10/03). (Fisher Cats Ballpark – Exit 8 off Appointments and Panels: Board I93) of Directors, Dudley Wright Center for Todd Wimpfheimer North Shore Spirit – A Science Education, Tufts University Education: B.A. 1987, Colgate vs. Quebec Les Capitales 1993-present; Chair, Workshop Essen- University; Ph.D. 1993, UCLA Sunday, July 2, 2:05 pm tial Visualization Tools, 2005 Chair, Professional Experience: Salem (Fraser Field – on Rt. 107 Lynn) Workshop on Visualization Tools, State College (1994-present), currently Nashua Pride - A 2003; Vibrational Spectroscopy Ses- Associate Professor and Chair, Depart- vs. Sussex Seahawks sion Chair, FACSS 2002; Session ment of Chemistry and Physics. Saturday, July 15, 7:05 pm Chair, Dynamics at Surfaces, 2003; ACS Service: Member, (1991-pres- (Holman Stadium - Exit 7E off Rt. 3) Symposium CoOrganizer, Symposium ent) on Vibrational Spectroscopy at Sur- Brockton Rox - A NESACS Service: Member; I have vs. New Haven Cutters faces, 2006 National ACS Meeting attended and presented at meetings, Memberships: American Chemical Sunday, August 6, 5:05 pm and look forward to serving on this (Campanelli Stadium - Exit 17A off Society, American Physical Society, committee. ◆ Sigma Xi, Iota Sigma Pi Rt. 24 ) What exactly goes on at NESACS’ Lowell Spinners - A vs. Tri-City Valley Cats Dean Wilcox monthly Board meetings? Education: BS (1978), MS (1979), Sunday, August 20, 5:05 pm Chemistry, University of California at www.nesacs.org/reports (LeLacheur Park - Lowell Connector off Rt. 3) ◆

26 The Nucleus May 2006 Summary of Governance Actions 231st ACS National Meeting Atlanta, GA - March 26-30, 2006 By Morton Z. Hoffman

ACTIONS OF THE COUNCIL Large James D. Burke (ef fective Society Initiatives December 31, 2006). Ballots will be Many ACS committees and coun- Election Results mailed to the Council on or before cilor caucuses discussed and/or pro- The Committee on Nominations October 10. vided input into three key Society and Elections presented to the Council initiatives: the following nominees for selection as Committee Review As part of a regular review, the The Society’s new vision state- candidates for President-Elect, 2007: ment: “Improving people’s lives Bruce E. Bursten, Richard Eisenberg, Council VOTED to continue the Com- mittee on Admissions and the Commit- through the transforming power of Bassam Z. Shakhashiri, and Matthew chemistry,” which resulted from the tee on Professional Training. The V. Tirrell. By written ballot the Coun - input of several thousand ACS Committee on Admissions has the mem- cil selected Bruce E. Bursten and Bas - bers, was unveiled and discussed at sam Z. Shakhashiri as candidates for power to interpret and apply the requirements for membership, includ- this meeting. 2007 President-Elect. These two can- The Board-Council Policy Com- didates will stand for election in the ing determining status of applicants educated in foreign countries. The mittee Governance Review Task Force Fall National Election. was charged with reviewing the Soci- The Committee on Nominations Committee on Professional Training promotes and assists in the develop- ety’s governance, and Constitution and and Elections announced the results of Bylaws, to ensure that the Society has the election to select candidates from ment of high standards of excellence in all aspects of post-secondary chemical a governing framework to enable it to the list of nominees to represent Dis- best fulfill its mission, meet member trict I and District V on the Board of education, and undertakes studies important to their maintenance. needs, and remain a world-class organ- Directors for the term 2007-2009. ization. The task force developed a Nominees for District I included: D. The Society’s Finances framework that emphasized five key Richard Cobb, Thomas R. Gilbert, The Society ended 2005 with a net elements of the Society’s governance, Peter C. Jurs, and Anne T. O’Brien. contribution from operations of $11.6 which are: membership, geographical Nominees for District V included John million, which was $9.1 million favor - organization, disciplinary organization, E. Adams, Judith L. Benham, Richard able to the approved budget. The governance structure, and governance S. Givens, and Josef Michl. By mail favorable variance was primarily operations. ballot the Council selected Thomas R. attributable to higher-than-budgeted A Program Review Advisory Gilbert and Anne T. O’Brien as District print and electronic information serv- Group (PRAG) has been established to I candidates; and as District V candi- ices revenue and investment income, assist the Committee on Budget and dates, John E. Adams and Judith L. as well as expense savings from staff Finance in reviewing all programs of Benham. Ballots will be mailed on or vacancies and reductions in informa- the Society (with some exemptions) on before October 10 to all members in tion technology spending. The Society a periodic and regular basis. The District I and District V for election of also realized $21.0 million in invest- PRAG consists of councilors, members a Director for each District. ment gains. In total, unrestricted net of the Board of Directors, members of Candidates for Directors-at-Large assets increased just over $26 million the Committee on Budget and Finance, The Committee on Nominations in 2005 to $211 million, and the Soci- and representatives from the commit- and Elections announced the selection ety ended 2005 in full compliance with tees with oversight over the programs of the following candidates for Direc- the Board-established financial guide- under review in a given year. lines. tors-at-Large for a 2007-2009 term: Member Statistics William H. (Jack) Breazeale, Jr., Den- Registration Report ACS closed 2005 with 158,422 nis Chamot, Peter K. Dorhout, Paul R. As of March 28, 2006, the ACS members, reversing a 4-year down- Jones, Valerie J. Kuck, and Dorothy J. spring national meeting had attracted ward trend in Society membership. Of Phillips. The election of three Direc- 12,546 registrants as follows: Regular the 15,532 applications processed in tors-at-Large will be conducted in the attendees 6,323; Students 4,158; 2005, nearly 900 came from the Mem - fall. Two candidates will fill the Exhibitors 1,288; Exposition only 413; ber-Get-A-Member campaign, in 2007-2009 term, and one will fill a and Guests 364. which many councilors participated. two-year vacancy for 2007-2008 cre- The membership retention number ated by the resignation of Director-at- remained stable at 92.4%.

The Nucleus May 2006 27 Governance ACTIONS OF THE BOARD Committee on Public Affairs and Pub- lic Relations, upon recommendation of Continued from page 27 OF DIRECTORS the ad hoc Committee on National His- Special Discussion The Special Temporary Assessment toric Chemical Landmarks. A special discussion item was put In December 2002, the Board of The Board also received updates on the Council agenda for this meet- Directors approved a special temporary and reports from its Green Chemistry ing. The discussion focused on mem- assessment to cover the costs of Institute Task Force, the Board-Coun- bership – specifically, the requirements increased funding for divisions and cil Policy Committee Governance for ACS membership, and whether local sections. This funding increase Review Task Force, the Percy Julian they should be made more or less resulted from the Petition for Division Task Force, and the Contingency Plan - restrictive, or kept the same. ACS and Local Section Funding, which was ning Working Group. The Board voted President E. Ann Nalley invited the co- subsequently approved by the ACS to adopt several recommendations as chairs of the Board-Council Policy Council, Board, and membership in presented by its Green Chemistry Insti- Committee Governance Review Task 2003. The Board enacted the tempo- tute Task Force. Force, James D. Burke and William F. rary assessment with the understanding that it would be reviewed each year to The Society’s Staff Carroll, to help frame the discussion The Executive Director/CEO and by presenting the results of a councilor determine whether it could be reduced. In light of the Society’s strong finan- several of her direct reports updated survey on ACS membership require- the Board on an upcoming workshop ments. cial performance, the Board VOTED that, rather than enacting the assess- on evolving information/technologies 2006 Member Dues ment of $8 scheduled for 2007, that the and trends, key initiatives related to The Council VOTED to set the assessment would be reduced to $4. Washington information technology - member dues for 2007 at the fully 2007 is the final year for the Special including the Web Presence project - escalated rate of $132. Assessment. and the activities of Chemical Abstracts Service, the Publications Division, and Future National Meetings The Board’s Committees and Task the ACS General Counsel. The Council VOTED to recom- Forces The Executive Director/CEO, mend to the Board of Directors that the The Board received a report of the joined by Dr. Robert Lichter of Merri- spring meeting for 2015 be held in screened list of candidates from the mack Consultants, reported on the sta- Denver, Colorado, March 22-26; and Committee on Grants and Awards for tus of a review of the educational that the fall meeting be held in Boston, the 2007 Priestley Medal, the Volun- Massachusetts, August 16-20. The activities at the Society – including teer Service Award, and the Parsons those of the ACS Education Division. Council also voted to recommend loca- Award. The Board will announce the tions and dates for the 2016 meeting as winners after its June meeting. Compensation of the Society’s Exec- follows: the spring meeting to be held The Board voted to adopt an utive Staff on March 13-17, in San Diego, Cali- amendment to its Regulations that del - On the recommendation of the fornia; and the fall meeting to be held egates authority to approve the Soci- Committee on Executive Compensa- in Philadelphia, Pennsylvania, on ety’s National Historic Chemical tion, the Board voted to approve sev- August 21-25. Landmark designations to the Board’s eral actions relative to compensation

March 2006 Meeting Pictures Courtesy of Ms. Ying Wei

Nucleus Editor Dr. Michael Filosa with Speak- Professor Daniel Nocera introducing Richards NESACS Chair, Pam Mabrouk presents the ers Bureau Head, Dr. Jin Ji Medal Winner Professor Richard R. Schrock Richards Medal to Professor Richard R. Schrock

28 The Nucleus May 2006 BUSINESS DIRECTORY

SERVICES SERVICES Governance Continued from page 28 for the Society’s Executive staff. The compensation of the Society’s Execu- tive Staff receives regular review from the Board. 2006 Board Goals At the December 2005 meeting, the Board approved its own set of goals and metrics to help achieve successful implementation of the Society’s strate- gic plan. At this meeting, the Board received an update on its progress toward achieving these goals. The Board’s Activity in the Commu- nity The Board considered an opportu- nity to participate in a community building activity in the San Francisco Bay Area while attending the fall 2006 ACS National Meeting in San Fran- cisco. The activity, to be planned by local section organizers, focuses on the National Chemistry Week theme: “Your Home: It’s all Built on Chem- istry.” The Board plans to readjust its schedule to allow for participation by its members. ◆ © 2005 sc ence-driven All rights reserved. Amgen.

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The Nucleus May 2006 31 Harvard, MA 19 Mill Road

May 2 May 18 Prof. Heinz Roth, Rutgers University Robert M. Williams, Colorado State University, “History of Photochemistry” and Mohammad Movassaghi, MIT Univ. New Hampshire, Iddles Auditorium, L103, Title: TBA 01451 11AM Organic Seminar Series Prof. Robert Williams, Colorado State MIT, 6-120, 4:00PM University May16 “Total Synthesis as a Vehicle to Penetrate Prof. David MacMillan, California Institute of Biosynthesis and Biomechanism” Technology Bristol-Myers Squibb Corporation Symposium, “New Catalysis Concepts Sponsored by Boston College, Merkert 130, 4PM Schering-Plough” Mark Howarth, MIT Chemistry Ting Lab Boston College, Merkert 130, 4PM Title: “Single-particle imaging in living cells with biotin ligase and re-engineered May 25 streptavidin” Symposium on the Synthesis of Organic MIT, Rm 56-114 4:00PM Structures with Exceptional Properties May 4 Rik Tykwinsky (University of Alberta) 9:30am “ A Carbenoid Approach to Polyynes with Prof. Petyer Tonnies (Institut fur Astrophysik Unique Properties” Gottingen) Harvard / MIT Pchem Seminar Series Jack B. Howard (Nano-C, Inc. Professor Harvard Univ. Pfizer Lecture Hall, 5:00p EmeritusMIT) 10:45am

AMERICAN CHEMICAL “Synthesis of Fullerenes and Nanotubes in U.S. POSTAGE P OPOI ORG. NONPROFIT NOR May 8 Flames - From Laboratory Research to

SOCIETY SECTION Prof. Devarajan Thirumalai, University of Industrial Production” THEASTERN Maryland Jeffrey S. Moore (University of Illinois at Title.TBA Urbana-Champaign) 2:00pm Physical Seminar Series

AID “Foldamer Heterosequences: Modular and MIT, Rm 56-114, 4:30PM Customizable Molecular Containers” May 8-9 Lawrence T. Scott (Boston College) 3:15pm Professor Larry E. Overman (U.C. Irvine) “Strategies for the Rational Chemical Synthesis (May 8) “New Strategies for Ring Construction: of Carbon Nanotubes” Exploratory Studies and Natural Total Product Boston College, Merkert 127. Calendar Synthesis.” (May 9) “Total Synthesis of (-)-Sarain A” Notices for the Nucleus Max Tishler Prize Lectures Calendar FOR MARCH 2006 Check the NESACS Homepage Harvard Univ. Pfizer Lecture Hall, 4:15 p.m AND THE FOLLOWING MONTHS for late additions: May 9 should be sent to: http://www.NESACS.org Prof. Suzanne Walker(Harvard Medical School, Sheila E Rodman Note also the Chemistry Department web Chemistry and Chemical Biology) 250 Kennedy Drive pages for travel directions and updates. Title: TBA Unit #403, Malden, MA 02148. These include: Biological Seminar Series E-MAIL: serodman(at)hotmail.com http://chemserv.bc.edu/seminar.html MIT, 56-114, 4:00PM http://www.bu.edu/chemistry/events/ http://www.chem.brandeis.edu/colloquium.shtml May 11 http://www-chem.harvard.edu/events/ Carl Decicco,(Bristol Myers-Squibb) and David http://web.mit.edu/chemistry/ B. Collum (Cornell University) www.chem.neu.edu/web/calendar/index.html Title:TBA http://chem.tufts.edu/seminars.html [CHEM.] MIT, 6-120, 4:00PM http://ase.tufts.edu/chemical/seminar.htm [CHEM. ENGG.] May 15 http://www.chem.umb.edu/ Professor Atsushi Miyawaki (RIKEN Brain www.umassd.edu/cas/chemistry/seminars.cfm Sciences Institute, Japan) www.uml.edu/Dept/Chemistry/speakers.html Title TBA http://www.unh.edu/chemistry/seminars.html Woodward Lecture Series in the Chemical Sciences/Organic Chemistry Seminar May 1 Harvard Univ. Pfizer Lecture Hall 4:15 p.m Professor Matthew Francis (U.C. Berkeley) Robert Tyco, NIH Title TBA Title: TBA Woodward Lecture Series in the Chemical Physical Seminar Series Sciences/Organic Chemistry Seminar MIT, 56-114,4:30p Pfizer Lecture Hall, 12 Oxford St., Cambridge. 4:15 p.m. May16 Prof. Ka Yee Lee (University of Chicago) Prof. David MacMillan, California Institute of Title: TBA Technology Physical Seminar Series “New Catalysis Concepts Sponsored by MIT, 56-114 4:30PM Schering-Plough” Boston College, Merkert 130, 4PM