Distribution of Lymph Node Metastases in Esophageal Carcinoma [TIGER Study]: Study Protocol of a Multinational Observational Study Eliza R
Hagens et al. BMC Cancer (2019) 19:662 https://doi.org/10.1186/s12885-019-5761-7 STUDY PROTOCOL Open Access Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study Eliza R. C. Hagens1, Mark I. van Berge Henegouwen1, Johanna W. van Sandick2, Miguel A. Cuesta3, Donald L. van der Peet3, Joos Heisterkamp4, Grard A. P. Nieuwenhuijzen5, Camiel Rosman6, Joris J. G. Scheepers7, Meindert N. Sosef8, Richard van Hillegersberg9, Sjoerd M. Lagarde10, Magnus Nilsson11, Jari Räsänen12, Philippe Nafteux13, Piet Pattyn14, Arnulf H. Hölscher15, Wolfgang Schröder16, Paul M. Schneider17, Christophe Mariette18, Carlo Castoro19, Luigi Bonavina20, Riccardo Rosati21, Giovanni de Manzoni22, Sandro Mattioli23, Josep Roig Garcia24, Manuel Pera25, Michael Griffin26, Paul Wilkerson27, M. Asif Chaudry28, Bruno Sgromo29, Olga Tucker30, Edward Cheong31, Krishna Moorthy32, Thomas N. Walsh33, John Reynolds34, Yuji Tachimori35, Haruhiro Inoue36, Hisahiro Matsubara37, Shin-ichi Kosugi38, Haiquan Chen39, Simon Y. K. Law40, C. S. Pramesh41, Shailesh P. Puntambekar42, Sudish Murthy43, Philip Linden44, Wayne L. Hofstetter45, Madhan K. Kuppusamy46, K. Robert Shen47, Gail E. Darling48, Flávio D. Sabino49, Peter P. Grimminger50, Sybren L. Meijer1, Jacques J. G. H. M. Bergman1, Maarten C. C. M. Hulshof1, Hanneke W. M. van Laarhoven1, Banafsche Mearadji1, Roel J. Bennink1, Jouke T. Annema1, Marcel G. W. Dijkgraaf1 and Suzanne S. Gisbertz1,51* Abstract Background: An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached.
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