DOCSLIB.ORG

Natural Compounds Chemistry

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Natural Compounds Chemistry Migal- Galilee Research Institute Our goal is to lead outstanding and impactful research while collaborating with industry, academy and research institutes. Was established in 1979 (100% The Biggest researCh institute in the ownership of the Galilee Galilee and the Golan heights (Mega 01 Development). Funded by the Ministry 02 R&D) of SCienCe 41 ResearCh groups, 296 Employees, 7500 sq ft of lab spaCe in Kiryat 03 83 PhD. 04 Shmona and Tel-Hai Industrial park. Affiliated with Tel-Hai College In the process of building a new laboratory building in Tel Hai campus. EconomiC Development Region & ECosystem AcademiC ExCellence Tel-Hai College Introductory Presentation Innovation's True North Examples of research fields among leading Research professors and researchers Faculty of Sciences and Technology Hydrochemistry Environmental Chemistry Prof. Michael Litaor Prof. Giora Rytwo Official affiliation with MIGAL - Applied scientific research, Galilee Research Institute specializing in the fields of Natural compounds Immunology biotechnology, environmental and agriculture sciences Prof. Soliman Khatib Prof. Gidi Gross Molecular Genetics in Human Health Agriculture and Nutrition Sciences Prof. Martin Goldway Prof. Snait Tamir Plant Metabolism Prof. Rachel Amir Academics Faculty of Sciences & Technology B.Sc. M.Sc. Biotechnology Biotechnology- Thesis track Nutrition Science Nutritional- Thesis track Food Science Water Science- Thesis track Animal Science Computer Science Graduate School Computer Science Environmental Science Pre-Med Studies Number of students Number of Employees Statistics 5,000 1,000 Our students Where do our students come from? Where do our students continue on to? Graduates Type of Studies Number of Students Percentage M.Sc. 371 16.3 M.A. 823 36.2 Doctorate 126 5.5 Post Doctorate 1 0.04 Explore Community Creativity International EntrepreneurshipSuccess Leaders Sharing Academia INNOVATION ResearchTel-HaiAcademiCs 2030Excellence Pioneering Opportunities Dream Collaborations Expending Implement Curiosity Quality Knowledge Scientific Structure Supreme Scientific 1 Council 2 Internal Scientific Council Scientific Director 3 4 Department Managers Head of the 5 research group Due to our scope of operation, number of researches, and the composition of the Supreme Scientific Council, per the criteria set forth by the Ministry of Science we are not required to have an academic sponsorship from another intitute . Scientific Council Name Academic Institution Field Prof. Aaron Ciechanover Technion Chemistry Prof. Yitzhak Apeloig Technion Chemistry Prof. Rafael (Rafi) Beyar Technion/Rambam H Medicine Prof. Gadi Schuster Technion Biology Prof. Moshe Shoham Technion Medical Robotics Prof. Ohad Birk Ben Gurion University Genetics Prof. Michal Shapira Ben Gurion University Biology Prof. Hanoch Gutfreund Hebrew University Physics Prof. Yitzhak Hadar Hebrew University Microbiology Prof. Hermona Soreq Hebrew University Biological Chemistry Prof. Oded Shoseyov Hebrew University Biotechnology Prof. Tamar Peretz Hebrew University/Hadassah H Oncology Prof. Tamar Dayan Tel - Aviv University Oncology Scientific Council Name Academic Institution Field Prof. Yoseph Mekori Immunology Tel Hai College Prof. Dan Levanon Biotechnology/Scientific Director MIGAL Prof.Giora Rytwo Chemistry MIGAL/Tel Hai College Prof. Michael Litaor Chemistry MIGAL/Tel Hai College Prof. Gideon Gross Immunology MIGAL/Tel Hai College Prof. Snait Tamir Nutrition MIGAL/Tel Hai College Prof. Rachel Amir Biology MIGAL/Tel Hai College Prof. Gad Degani Endocrinology MIGAL/Tel Hai College Prof. Jacob Pitcovski Immunology MIGAL/Tel Hai College Migal Structure- Research Departments and Services Units Plant SCienCe BioteChnology Nutrition and Soil Water and Natural ProduCts Environment Post Harvest North R&D innovation Center Main research disciplines Title of the Slide Subject Environmental Biotechnology Biochemistry Food Chemistry Computational Smart Agriculture Sciences and Research Bioinformatics Food & Biobase Plant Research Post Harvest Livestock Cannabis research Nutrition Northern R&D – an independent unit within MIGAL “MOP TZAFON” is the agricultural R&D unit in the north. It outlines, coordinates and executes the applicatory agricultural research and development in the northern part of Israel. v Operates in all the Gallil & Golan districts and also in the Jorden valley. v Production of over 6 billion NIS fresh produce year. v Sub topo climatic regions from -200m and up to 1200m above see level. v Vast types of soils, water quality and availability. v Research is performed in 10 different experiment sites. Migal Regional Value Creation platform Excellence Center Community R&D Local Galil Municipalities Develop ment Education קחמ ר ח Education Food Tech חותפו חותפו Industry Industry Startups Accelerator University Research Institute — Scientific Excellence 160 160 160 80 220 80 220 80 220 0 280 0 280 0 280 Scientific Excellence, Business model, Centers of Excellence Regional Development Bioinformatics v During the upcoming decade v 18-22startup companies v Center of excellence for we plan to hire v Collaborations with the vaccine development v 16-20young chief industry and agriculture v The Center for Plant researchers leaders Biodiversity Research, and v 30-40research staff v Computational and potential uses as crops and members Bioinformatics educational medical herbs v 4-6senior scientists for and training programs v Sustainability, Agriculture, limited terms v Implementing the Climate, and the v 20-25doctoral student and computational aspect in all Environment postdoctoral researchers our research fields GALIL CENTER OF EXCELLENCE FOR VACCINE DEVELOPMENT NEXT-GENERATION DIFFERENTIATION FOCUS PROJECTS PARTNERS VACCINES ü Accelerating and de-risking ü The multi-disciplinary ü Develop platform technologies the development of new capabilities, facilities and as building blocks including ü Ministry of Science and vaccines varied expertise of its Structural biology and Technology ü Developing specific oral founding partners. bioinformatics tools. ü MIGAL Galilee Research vaccines as a “Proof of ü The physical proximity of its ü Develop next-generation Institute Concept” main laboratory and clinical diagnostic tools including an ü Rambam Medical Cente ü Improving the ability to facilities “in-silico” system ü Technion – Israel predict and develop highly ü Israel’s “start-up nation” ü Developing a model to enable Institute of Technology active vaccines cultural mentality accurate prediction, to ü Stanford University development of wide-range ü The Israel Veterinary vaccines against fast-changing institute and newly emerging viruses (e.g. influenza, coronavirus etc.). The best framework would be a Center of Excellence to function as an umbrella organization for prioritizing, funding and managing multi-disciplinary projects carried out through collaborations between innovative academic, applied research and medical institutions. Senior Research Scientist positions Organic Chemistry Soil Chemistry Focusing on Natural Compounds Chemistry: isolation Prioritized subjects: nutrient modeling, enviro-friendly and activity of health-promoting and food-related fertilizer/pesticide application, precision agriculture natural compounds, rational synthesis of bioactive methods (e.g., soil proximal survey techniques, molecules, metabolomics. multispectral analysis). Plant Sciences Immunology Focusing on natural compounds for Health-Value Foods With focus on either immunotherapy or vaccinology: (background and experience in botany, biochemistry emerging methods for wide-range vaccines, design of molecular biology, and genetics). effective adjuvants to stimulate innate immunity and active cellular immunotherapy. Plant Genomics Computational/Synthetic Biology Covering areas such as evolution, development, Advanced computational methods to study operating physiology, ecology, and plant interactions with other principles of complex biological systems (from intra/ organisms (background in comparative and functional inter-cellular down to metabolic pathways), design and genomics and expertise in bioinformatics). engineering of small biomolecules. Sphingolipids and bioactive compounds in inflammation and cancer Lab Dr. Dorit Avni Research Group Leader Sphingolipids and bioactive compounds in inflammation and cancer. [email protected] https://www.migal.org.il/en/node/6848 AcademiC Positions 2018-present, Head of sphingolipids and immune modules laboratory, MIGAL 2012-2016, Postdoctoral Fellow at Massey Cancer Center, VCU-MCV, USA. Topics of research 1. Role of sphingolipids in health and disease 2. Natural bioactive compounds as immune regulators # Holistic approach - The use of nutritional and natural compounds as prevention or treatment for human disease and the regulation of the immune system # Identifying unmet disease and providing new platforms and solutions:COVID19, IBD, NAFLD, gastric ulcer, TNBC, liver cancer Our research comprises of both basic and translational programs Our laboratory specializes in in-vitro, ex-vivo and pre-clinical models and we take a transdisciplinary approach in our research using immunologic, genomic, and metabolomic approaches to study our open questions. Vascular signaling Lab Dr. Andrea Szuchman-Sapir Research Group Leader Vascular signaling Lab. [email protected] https://www.migal.org.il/en/Andrea-Szuchman-Sapir Academic Positions Ph.D. 2006, Technion Faculty of Medicine, Haifa, Israel. 2017- Head of the Laboratory of vascular signaling research, Migal-Galilee
Load more

Recommended publications
  • NIBN Establishing Why the NIBN NIBN Prof
    REPORT Highlight on NIBN Establishing Why the NIBN NIBN Prof. Varda Shoshan-Barmatz Prof. Irun R. Cohen, MD, Director Deputy Director Prof. Sir Aaron Klug, OM, FRS Many have asked how Israel might succeed The National Institute for Biotechnology in in achieving greater returns in intellectual the Negev (NIBN) is proud to publish this Chair of the International NIBN REPORT. Advisory Committee property and biotechnology products for a The purpose of the NIBN REPORT is to given investment in basic research in the summarize the progress and achievements It is now five years since we first made life sciences. Or to be more specific, why of the NIBN, which is at the spearhead of the approach to the Government for do I think the NIBN will be more effective the University's efforts to promote excellence funding a National Institute of than previous efforts in launching successful in research. The NIBN, made possible biotechnology. I shall answer that question Biotechnology in the Negev at BGU. through the magnanimous support and by summarizing the problems inherent in vision of Dr. h.c. Edgar de Picciotto of The basis was to be the Institute of Applied the relationship between university research Switzerland, brings together scientists from Biosciences which had been built and and biotechnology to clarify the rationale different disciplines with medical personnel funded with the generous support of of the NIBN model and its implementation. and professional consultants to create a Dr. h.c. Edgar de Picciotto of Geneva. front-line interdisciplinary institute focusing University and Biotechnology on biotechnology. It was his vision that this Institute could in Conflict of Interest Revolutions come in stages, and we have and would form the nucleus of a future now advanced from the first stages of National Center for Biotechnology.
    [Show full text]
  • Full Schedule ILANIT 20Th-23Rd of February 2017
    Full Schedule ILANIT 20th-23rd of February 2017 ILANIT / FISEB Federation of all the Israel Societies for Experimental Biology (FISEB) איגוד האגודות הישראליות לביולוגיה ניסויית )אילנית( ILANIT/FISEB is a federation of 31 Israeli societies of experimental biology. ILANIT’s conference is held every three years in Eilat, with attendance by researchers and students. This conference, held in February 2017, is the culmination of the most exciting research performed in Israel in many disciplines. Board President Treasurer Secretary Prof. Karen B. Avraham Prof. Yaron Shav-Tal Prof. Eitan Yefenof (TEL AVIV UNIVERSITY) (BIU) (HUJI) Scientific Organizing Committee Conference President Conference Vice Conference Deputy Conference Vice Orna Amster-Choder President President President (HUJI) Maya Schuldiner (WIS) Angel Porgador (BGU) Eli Pikarsky (HUJI) 2 Last updated 15.02.2017 Scientific Advisory Committee Molecular and Structural Biology and Biochemistry Orna Elroy-Stein, Tel Aviv University (Chair) Ora Furman, Hebrew University of Jerusalem Shula Michaeli, Bar Ilan University Neurobiology and Endocrinology Yuval Dor, Hebrew University of Jerusalem (Chair) Yadin Dudai, Weizmann Institute of Science Assaf Rudich, Ben Gurion University of the Negev Genetics, Genomics, Epigenetics, Bioinformatics and Systems Biology Tzachi Pilpel, Weizmann Institute of Science (Chair) Ohad Birk, Ben Gurion University of the Negev Howard Cedar, Hebrew University of Jerusalem Yael Mandel, Technion – Israel Institute of Technology Medicine, Immunology and Cancer
    [Show full text]
  • Transformative Research at Ben-Gurion University of the Negev
    A DECADE OF TRANSFORMATIVE RESEARCH AT BEN-GURION UNIVERSITY OF THE NEGEV APRIL 2014 "Understanding the secrets of nature will be our greatest endeavor." David Ben-Gurion From the President 3 From the Vice-President and Dean for R&D 4 Leading The Way Ilse Katz Institute for Nanoscale Science and Technology 6 Homeland Security Institute 12 Cyber Security Initiative 16 Jacob Blaustein Institutes for Desert Research 20 Zuckerberg Institute for Water Research 21 French Associates Institute for Agriculture & Biotechnology of Drylands 24 The Swiss Institute for Dryland Environmental and Energy Research 27 Ben-Gurion National Solar Energy Center 29 The National Institute for Biotechnology in the Negev 32 Zlotowski Center for Neuroscience 38 The Edmond J. Safra Center for the Design and Engineering of Functional Biopolymers in the Negev 42 The Bengis Center for Entrepreneurship and Hi-Tech Management 44 Jacques Loeb Centre for the History and Philosophy of the Life Sciences 46 Center for the Study of Conversion and Inter-Religious Encounters 47 The Ben-Gurion Research Institute for the Study of Israel and Zionism 48 HEKSHERIM – the Research Institute for Jewish and Israeli Literature & Culture 49 Research Diversity Humanities Research at BGU 51 Medical Research at BGU 56 The BGU Energy Initiative 60 Robotics Research at BGU 63 The Research & Development Authority 66 Facilitating Innovation BGN Technologies 68 Advanced Technologies Park 70 Ten Years of Leadership in R&D 71 Produced by the Office of the Vice President & Dean for Research and Development in cooperation with the Scientific Publications Section and the Department of Publications and Media Relations.
    [Show full text]
  • REPORT PLA2G6 Mutation Underlies Infantile Neuroaxonal Dystrophy
    CORE Metadata, citation and similar papers at core.ac.uk Provided by Elsevier - Publisher Connector REPORT PLA2G6 Mutation Underlies Infantile Neuroaxonal Dystrophy Shareef Khateeb,* Hagit Flusser,* Rivka Ofir, Ilan Shelef, Ginat Narkis, Gideon Vardi, Zamir Shorer, Rachel Levy, Aharon Galil, Khalil Elbedour, and Ohad S. Birk Infantile neuroaxonal dystrophy (INAD) is an autosomal recessive progressive neurodegenerative disease that presents within the first 2 years of life and culminates in death by age 10 years. Affected individuals from two unrelated Bedouin Israeli kindreds were studied. Brain imaging demonstrated diffuse cerebellar atrophy and abnormal iron deposition in the medial and lateral globus pallidum. Progressive white-matter disease and reduction of the N-acetyl aspartate:chro- mium ratio were evident on magnetic resonance spectroscopy, suggesting loss of myelination. The clinical and radiological diagnosis of INAD was verified by sural nerve biopsy. The disease gene was mapped to a 1.17-Mb locus on chromosome 22q13.1 (LOD score 4.7 at recombination fraction 0 for SNP rs139897), and an underlying mutation common to both affected families was identified in PLA2G6, the gene encoding phospholipase A2 group VI (cytosolic, calcium-indepen- dent). These findings highlight a role of phospholipase in neurodegenerative disorders. Infantile neuroaxonal dystrophy (INAD) (MIM 256600) is in INAD. PKAN usually has a late-infantile or juvenile age a neurodegenerative disease characterized by pathologic at onset, with patients typically surviving into their 3rd axonal swelling and spheroid bodies in the CNS.1 Onset decade.5 It is noteworthy that early-onset cases of PKAN is within the first 2 years of life, and the disease culminates and late-onset cases of INAD have been reported.5 Linkage in death by age 10 years.
    [Show full text]
  • Research at the NIBN
    Research at the NIBN Engineering affinity scaffolds for cancer imaging and therapy Itay Cohen and Dr. Niv Papo Research at the NIBN Ben-Gurion UNIVERSITY OF THE NEGEV Contents NIBN Overview 5 Cancer Research Group 6 Dr. Eyal Arbely 7 Dr. Roi Gazit 8 Dr. Dan Levy 9 Dr. Niv Papo 10 Prof. Angel Porgador 11 Dr. Barak Rotblat 12 Prof. Varda Shoshan-Barmatz 13 Autoimmune and Metabolic Diseases Group 14 Prof. Amir Aharoni 15 Prof. Angel Porgador 16 Prof. Assaf Rudich 17 Prof. Orian Shirihai 18 Neurodegenerative Diseases Group 19 Dr. Anat Ben-Zvi 20 Prof. Alon Monsonego 21 Prof. Israel Sekler 22 Prof. Varda Shoshan-Barmatz 23 Infectious Diseases Group 24 Dr. Natalie Elia 25 Dr. Eyal Gur 26 Dr. Tomer Hertz 27 Prof. Michael M. Meijler 28 Human Genetic Disorders Group 29 Prof. Ohad Birk 30 Prof. Ruti Parvari 31 Dr. Esti Yeger-Lotem 32 Applied Biotechnology Group 33 Prof. Ohad Medalia 34 Prof. Amir Sagi 35 Dr. Raz Zarivach 36 Dr. Stas Engel 37 Infra-Structure Supporting Group 38 Bioinformatics Core Facility 39 Crystallography Unit 40 Genetics Unit 41 Cytometry, Proteomic and Microscopy Unit 42 Dr. Roee Atlas 43 NIBN Overview The National Institute for Biotechnology in the Negev Using these approaches, NIBN has already succeeded (NIBN) Ltd. is the first, self-organized, independent to generate commercial outlets in the fields of drug scientific research and development (R&D) body in targets for cancer therapy and infectious diseases, Israel. It has been established through a tri-lateral anti-inflammatory drugs as well as major advances agreement between the government of Israel, in aquaculture technology.
    [Show full text]
  • Rare / Orphan Genetic Diseases: from Phenotype to Gene and Molecular Pathways Sponsored by the Ministry of Science and Technology Conference Web Site
    Rare / orphan genetic diseases: From phenotype to gene and molecular pathways Sponsored by the Ministry of Science and Technology Conference Web Site Wilhelmina Cohen Auditorium, Pediatric Division, Soroka Medical Center, Beer-Sheva May 17, 2018 09:00 – 09:30 Welcome and light refreshments 09:30 – 09:45 Opening remarks and introduction of the National Knowledge Center for Rare/Orphan diseases 09:45 – 10:15 Monogenic diseases: from phenotypes to genes, molecular pathways and disease prevention. Ohad Birk, Genetics Institute, Soroka Medical Center and Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University. 10:15 – 10:45 Genetic diseases in Israel - an overview. Joël Zlotogora, Faculty of Medicine, Hebrew University of Jerusalem. 10:45 – 11:15 From the genetic disease to the mechanism causing it: example from cardiomyopathy. Ruthi Parvari, Shraga Segal Department of Microbiology, Immunology and Genetics, Ben- Gurion University. 11:15 – 11:45 Coffee break 11:45 – 12:15 C. elegans as a model for human rare diseases: the role of fusion in shaping the mitochondrial network. Anat Ben-Zvi, Department of Life Sciences, Ben-Gurion University. 12:15 – 12:45 Induced pluripotent stem cells (iPSCs) as “disease in a dish” models for human inherited diseases. Rivki Ofir, BGU-iPSC Core Facility, Regenerative Medicine & Stem Cell Research Center, Ben- Gurion University. 12:45 – 13:15 The role of transcriptional enhancers in neurodevelopmental disorders. Ramon Birnbaum, Department of Life Sciences, Ben-Gurion University. 13:15 – 14:15 Lunch break 14:15 – 14:45 Elucidating the use of the fruit fly, Drosophila melanogaster, as a model for human rare diseases.
    [Show full text]
  • Cellular and Molecular Neuroscience: from Generation to Degeneration April 5-6, 2017 Mishkenot Sha’Ananim, Jerusalem
    Cellular and Molecular Neuroscience: From Generation to Degeneration April 5-6, 2017 Mishkenot Sha’ananim, Jerusalem Organizing Committee: Chaya Kalcheim, Eran Meshorer and Hermona Soreq Wednesday, April 5, 2017 8:45-9:00 – Opening remarks – Organizing Committee Keynote lecture Chair: Sami Sagol 9:00-9:45 – Heller lecture: Eric Kandel, Columbia University, USA The biology of memory and age related memory loss Session 1: Neural Development Chair: Chaya Kalcheim, Hadassah Hebrew University Medical Center, Israel 9:45-10:20 – Johan Ericson, Karolinska Institute, Sweden Composition of a timer regulating temporal identity and fate of neural stem cells 10:20-10:45 – Orly Reiner, Weizmann Institute of Science, Israel Human brain organoids on a chip to model normal development and disease 10:45-11:15 – Coffee break 11:15-11:40 – Avihu Klar, Hadassah Hebrew University Medical Center, Israel Characterization of neuronal circuits for coordinated limb movements in avians 11:40-12:15 – Joanna Wysocka, Stanford School of Medicine, USA Gene regulatory principles in human development, disease and evolution 12:15-12:40 – Oren Schuldiner, Weizmann Institute of Science, Israel From genetics to system, and back: A systematic exploration of neuronal remodeling reveals a transcription factor hierarchy 12:40-14:00 – Lunch break Session 2: From Gene to Synaptic Function Chair: Hermona Soreq, Hebrew University of Jerusalem, Israel 14:00-14:35 – Li-Huei Tsai, Massachusetts Institute of Technology, USA Bringing gamma back — using noninvasive sensory stimulation
    [Show full text]
  • Medical School Four Year Program Syllabi
    Medical School Four Year Program Syllabi In Accordance with the European Credit Transfer System (ECTS) and Learning Outcomes Academic Year 2019-20 Ben-Gurion University of the Negev Contents First year syllabi – Basic Science Courses Biochemistry…………..…………………………………………………………………………………………………. 6 Biostatistics………………………………………………………………………………………………………………...8 Emergency Medicine 1……………………………………………………………………………………………….10 Endocrine System……………………………………………………………………………………………………….12 Epidemiology……………………………………………………………………………………………………………..14 Genetics……………………………………………………………………………………………………………………..16 Hebrew Beginners……………………………………………………………………………………………………….18 Hematology System…………………………………………………………………………………………………….20 Histology……………………………………………………………………………………………………………………. 23 Immunology………………………………………………………………………………………………………………..25 Introduction to Basic Research Techniques…………………………………………………………………27 Introduction to Global Health 1&2………………………………………………………………………………29 Introduction to Oncology…………………………………………………………………………………………….34 Introduction to Patient Interview in Hebrew……………………………………………………………….36 Medical Ethics……………………………………………………………………………………………………………..38 Microbiology 1…………………………………………………………………………………………………………….40 Microbiology 2…………………………………………………………………………………………………………….42 Molecular and Cell Biology…………………………………………………………………………………………..44 On Being a Doctor 1&2………………………………………………………………………………………………..47 Pathology…………………………………………………………………………………………………………………….49 Pharmacology………………………………………………………………………………………………………………51 Physiology……………………………………………………………………………………………………………………55
    [Show full text]
  • The NIBN Is Currently in Its Fourth Year Since Its Establishment
    July 2013 3 Dear Friends: he NIBN is currently in its fourth year since its establishment Tin 2009 as an autonomous research institute. With NIBN’s mission of promoting applicative scientific projects with the intent for translation towards eventual commercialization, NIBN’s team continues to make significant inroads and navigate NIBN’s roadmap towards this goal. Several strides have been taken towards bridging the gap between basic and applied research, with the aim to raise interest among investors and big Pharmaceutical companies. The experienced NIBN team with Yuval Kupitz (MBA), responsible for business development and Lewis Neville (PhD), recently recruited as Deputy Director with expertise in drug development, aim to guide NIBN members towards an applicative avenue, creating novel projects whilst redirecting and focusing on others. NIBN’s financial support for performing research in the scientists’ laboratories or via outsourcing, together with appropriate business development opportunities, represent a unique approach present only in the NIBN. The International Scientific Advisory Board (SAB) continues to mentor and provide valuable consulting advice in helping to implement creative changes in the NIBN members’ research activities with respect to advancing the applied commercial aspects in parallel with basic research efforts. With the spirit of cooperation and entrepreneurship, we are now reaching a “critical mass” for significant industrial collaborations. This confirms that NIBN is becoming a renowned and highly respected center of scientific excellence. I would like to welcome the new NIBN SAB members, Prof. Nathan Nelson, Tel-Aviv University, Recipient of Israel Prize for Life Sciences, (2012), Director of the Daniella Rich Institute for Structural Biology and former President of the Israel Society for Biochemistry and Molecular Biology and Prof.
    [Show full text]
  • Molecular Chaperones and Cell Signalling
    P1: JZZ 0521836549agg.xml CB856/Henderson 0 521 83654 9 August 27, 1956 18:0 This page intentionally left blank P1: JZZ 0521836549agg.xml CB856/Henderson 0 521 83654 9 August 27, 1956 18:0 Molecular Chaperones and Cell Signalling This book reviews current understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress, and their dispo- sition within the cell. It also questions the basic paradigm of molecular chaperone biology – that these proteins are, first and foremost, protein-folding molecules. The current paradigms of protein secretion are reviewed, and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules, “moonlight- ing proteins,” is discussed. The role of exogenous molecular chaperones as cell regula- tors is examined, and the physiological and pathophysiological roles that molecular chaperones play are described. In the final section, the potential therapeutic use of molecular chaperones is described, and in the final chapter, the crystal ball is brought out and the question – what does the future hold for the extracellular biology of molecular chaperones – is asked. Brian Henderson is Professor of Cell Biology at the Eastman Dental Institute, University College London, and Head of the Cellular Microbiology Research Group. His major research interests are concerned with bacterial interactions with the host and how such interactions control inflammation and associated tissue destruction. It is through these studies that he identified that molecular chaperones are bacterial virulence factors and started his interest in the direct immunomodulatory actions of cell stress proteins.
    [Show full text]
  • A Hunt for Genes That Betrayed a Desert People - New York Times Page 1 of 4
    A Hunt for Genes That Betrayed a Desert People - New York Times Page 1 of 4 March 21, 2006 A Hunt for Genes That Betrayed a Desert People By DINA KRAFT HURA, Israel — In a sky blue bedroom they share but rarely leave, a young sister and brother lie in twin beds that swallow up their small motionless bodies, victims of a genetic disease so rare it does not even have a name. Moshira, 9, and Salame, 8, who began life as apparently healthy babies, fell into vegetative states after their first birthdays. Now their dark eyes stare enormous and uncomprehending into the stillness of their room. The silence is broken only by the boy's sputtering breaths and the flopping noise his sister's atrophied legs make when they fall, like those of a rag doll, upon the mattress. "I cannot bear it," said the children's father, Ismail, 37, turning to leave the room as his daughter coughs up strawberry yogurt his wife feeds her through a plastic syringe. The sick children are Bedouin. Until recently their ancestors were nomads who roamed the deserts of the Middle East and, as tradition dictated, often married cousins. Marrying within the family helped strengthen bonds among extended families struggling to survive the desert. But after centuries this custom of intermarriage has had devastating genetic effects. Bedouins do not carry more genetic mutations than the general population. But because so many marry relatives — some 65 percent of Bedouin in Israel's Negev marry first or second cousins — they have a significantly higher chance of marrying someone who carries the same mutations, increasing the odds they will have children with genetic diseases, researchers say.
    [Show full text]
  • The Genetics Institute at Soroka Medical Center the Genetics Institute at Soroka Medical Center, Headed by Prof
    The Genetics Institute at Soroka Medical Center The Genetics Institute at Soroka Medical Center, headed by Prof. Ohad Birk, brings together basic scientific research and effective translational clinical applications. It serves a population that includes some 800,000 Jews, mainly non-Ashkenazi, and a Bedouin community of about 250,000 people.The Bedouin community, in which it is common for people who are closely related to one another to marry and have children, is afflicted with many unique and severe hereditary diseases. In order to enable diagnosis and prevention of diseases that affect both the Jewish and Bedouin populations of the Negev as well as others, the genetics research lab studies and has deciphered the molecular bases and mechanisms of more than 40 human diseases, including some of the most prevalent and serious hereditary diseases of Arabs and Jews. In fact, three syndromes have been named after Prof. Birk. With his team at Soroka, Birk also implements his scientific findings in wide-scale, far-reaching carrier testing programs that have led to a 30% reduction in the infant mortality rate in the Bedouin community and the near-eradication of two of the hereditary diseases most common among Jews of Moroccan and Iraqi origin. Prof. Birk is a recipient of numerous awards and has published in top scientific journals such as Nature, Nature Genetics, PNAS, and the American Journal of Human Genetics. The translational impact of his work has also been well publicized in the lay press, from the New York The New York Times Times to Al Jazeera and BBC World.
    [Show full text]