Medical School Four Year Program Syllabi

In Accordance with the European Credit Transfer System (ECTS) and Learning Outcomes

Academic Year 2019-20 Ben-Gurion University of the Contents

First year syllabi – Basic Science Courses

Biochemistry…………..…………………………………………………………………………………………………. 6 Biostatistics………………………………………………………………………………………………………………...8 Emergency 1……………………………………………………………………………………………….10 Endocrine System……………………………………………………………………………………………………….12 Epidemiology……………………………………………………………………………………………………………..14 ……………………………………………………………………………………………………………………..16 Hebrew Beginners……………………………………………………………………………………………………….18 Hematology System…………………………………………………………………………………………………….20 Histology……………………………………………………………………………………………………………………. 23 Immunology………………………………………………………………………………………………………………..25 Introduction to Basic Research Techniques…………………………………………………………………27 Introduction to Global Health 1&2………………………………………………………………………………29 Introduction to Oncology…………………………………………………………………………………………….34 Introduction to Patient Interview in Hebrew……………………………………………………………….36 Medical Ethics……………………………………………………………………………………………………………..38 Microbiology 1…………………………………………………………………………………………………………….40 Microbiology 2…………………………………………………………………………………………………………….42 Molecular and Cell Biology…………………………………………………………………………………………..44 On Being a Doctor 1&2………………………………………………………………………………………………..47 Pathology…………………………………………………………………………………………………………………….49 Pharmacology………………………………………………………………………………………………………………51 Physiology……………………………………………………………………………………………………………………55

Global Health Modules

Health Inequities …….…………………………………………………………………………………………………..58

History of Medicine…….……………….……………………………………………………………………………...60

Medical Innovation Digital Health and Devices ……………………………………………………………62 Medicine & Literature…………………………………………………………………………………………………..64

Medicine & Society………………………………………………………………………………………………………66

Migration and Health…………….……………………………………………………………………………………..68

Introduction to Mindfulness…………………………………………………………………………………………70

Neglected Tropical Diseases…………………………………………………………………………………………73

Second year syllabi – Body Systems

Anatomy – Abdomen and Pelvis……………………………………………………………………………….….80

Anatomy – Chest and Thorax……………………………………………………………………………………….82

Anatomy – Head and Neck…………………………………………………………………………………………..84

Anatomy – Limbs………………………………………………………………………………………………………….86

Cardiovascular System………………………………………………………………………………………………….88

Clinical and Communication Skills 1&2………………………………..……………………………………….90

Embryology 1&2…………………………………………………………………………………………………………..93

Gastrointestinal System………………………….……………………………………………………………………95

Integration of the Basic Sciences (USMLE Review)……………………………………………………….97

Nephrology System……….…………………………………………………………………………………..……..….98

Neuroanatomy……………………………………………………………………………………………………………101

Neurology System..…………………………………………………………………………………………………… 103

Practicing Global Health in Specific Contexts 1&2………………………………………………………105

Psychiatry…………...………………………………………………………………………………………….……..….107

Reproductive System..……………………………………………………………………………….……………….109

Respiratory System..……………………………………………………………………………………….…….…...111

Rheumatology System…...………………………………………………………………………………………….113 Third Year Clinical Clerkships

Cross Cultural Medicine Workshop…………………………………………………………………………….116

Emergency Medicine 2……………………………………………………………………………….………………118

Family Medicine Clerkship……………………………………………………………………………………….…120

Internal Medicine Clerkship………………………………………………………………………………………..124

Neurology Clerkship……………………………………………………………………………………………………127

Obstetrics and Gynecology Clerkship…….……………………………………………………………………129

Pediatric Clerkship.….…………………………………………………………………………………………………131

Psychiatry Clerkship……………………………………………………………………………………………….…..134

Surgery Clerkship…………………………………………………………………………………………………..…..137

Fourth Year Electives, GHM Clerkship and Selectives

Elective……………………………………………………………………………………………………………………….141

Research Elective……………………………………………………………………………………………………….143

Sub-internship……………………………………………………………………………………………………………145

Global Health and Medicine Clerkship………………………………………………………………………..147

Anesthesiology…………………………………………………………………………………………………………..149

Dermatology .…………………………………………………………………………………………………………….150

ENT…………………………………………………………………………………………………………………………….151

Neurosurgery………………………………………………………………………………………………………….….152

Oncology.…..………………………………………………………………………………………………………………153

Ophthalmology…………………………………………………………………………………………………………..155

Orthopedics…………………………………………………………………………………………………………..…..156

Plastic Surgery……………………………………………………………………………………………………………159

Radiology/Imaging……………………………………………………………………………………………………..160 First year syllabi – Basic Science Courses

5 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Number of course: 481-8-1040

BGU Credits: 4 Course Description:

ECTS credits: Aims of the course: The overall objective of the biochemistry course is to provide the student with a Academic year: 2019-20 broad picture of the molecular and cellular basis of life. Semester: 1st semester Objectives of the course: Hours of instruction: 62 The students will learn the means by which living organisms transform energy and Lectures: 48 assemble molecules of great complexity to constitute the machinery of life. Tutorials: 14 Laboratories: Emphasis on inherited metabolic diseases which disturb the normal homeostasis will be included in each topic. Location of instruction:

Learning outcomes of the course: Faculty of Health Sciences classroom On successful completion of the course, the student should be able to: Language of instruction: 1. Know the various metabolic pathways in different organs with emphasis on regulation by metabolites and hormones English 2. Comprehend the complex metabolic system as a whole

Cycle: 1st 3. Be able to clinically analyze biochemical lab results 4. Understand the pathophysiology of various metabolic diseases Position: Mandatory course

Attendance regulation: Field of Education: MD Case study sessions (as indicated in the schedule) – Mandatory

Responsible department: Lectures – Optional but recommended

The department of clinical Teaching arrangement and method of instruction: biochemistry and pharmacology and The course is structured in the following way: MSIH  Self-learning  Lectures General prerequisites:  Discussion with the tutor on selective questions from the Units of Instruction. Chemistry and organic chemistry  Case discussion

Grading scale: Assessment: NMBE test Fail/Pass/Honors

Work and assignments: Optional- unit questions, cases and tutorials.

Time required for individual work: in addition to attendance in class, the students

are expected to do their assignments and individual work.

6 Ben-Gurion University of the Negev Medical School for International Health

Coordinator: Prof. N. Bashan Course Content\ schedule and outlines: Teacher: Prof. N. Bashan 1. Amino acids and protein structure- prerequisite\self-learning Contact details: 2. Enzymes- prerequisite\self-learning 3. Mitochondria Office phone : 4. Carbohydrates, Glycolysis Email: [email protected] 5. The Pentose Phosphate Pathway 6. Gluconeogenesis, galactose and fructose metabolism 7. Glycogen synthesis and degredation Office hours: To be coordinated by 8. Cell Signaling email 9. Lipid metabolism, synthesis and oxidation 10. Cholesterol and lipoprotein metabolism 11. Complex carbohydrates – SELF STUDY 12. Urea cycle Course evaluation: 13. Purine and pyrimidines Pass/Fail./Honors 14. Feed Fast Cycle, Diabetes and Obesity 15. Integrative cases

Confirmation: July 2019 Required reading: Principles of Biochemistry, Lehninger 4th, 5th or 6th editions. Last update: July 2019 Lippincott Biochemistry 4th ,5th or 6th editions.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

7 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Biostatistics Number of course: 481-8-1020

BGU Credits: Course Description: 2 ECTS credits: Aims of the course: Academic year: The introductory level Biostatistics course is designed to introduce students to the basic statistical methods that are most often used in medical literature. 2019-20 Semester: Objectives of the course: 1st 1. Students will learn the underlying theory and logic of Biostatistics, Hours of instruction: fundamental concepts, hypothesis testing, and sample size determination of statistical methods. Lectures: 14 2. Students will acquire the skills to critically read basic statistical results Tutorials: 28 presented in medical literature and to perform basic data analysis. Location of instruction: Learning outcomes of the course: On successful completion of the course, the Faculty of Health Sciences classrooms student should be able to: Language of instruction: English Attendance regulation: Cycle: Lectures - optional 1st Tutorials - mandatory Position: Mandatory course Teaching arrangement and method of instruction: Field of Education: Frontal lectures Small group tutorials MD Responsible department: Assessment: MSIH Assignments – 10% General prerequisites: Combined exam: Practical (SPSS program) and written- 90% None Grading scale: Work and assignments: Honors/Pass/Fail 8 mandatory homework assignments

Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: 3 hours per week.

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Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Jacob Dreiher Course Content\ schedule and outlines: Topics: Contact details: 1. Intro., descriptive statistics, on.

Office phone: Email: Adjustment [email protected] 2. The normal data distribution, confidence intervals, hypothesis testing and s ample size calculation 3. Chi square and correlations, repeated measures 4. T test and ANOVA Office hours: 5. Linear and logistic regression Days and hours when the lecturer 6. Survival analysis - Methodology of quality improvement and\or assistants are available at the 7. Critical appraisal of a research paper 4 (quality improvement) office for the students.

Self study: Descriptive Statistics Course evaluation:

Online student survey and debriefing Required reading: at the completion of the course.  Basic & Clinical Biostatistics, Dawson & Trapp, 4th ed. (some sections of chapters 3-6, 8) Confirmation:  Medical statistics, Kirkwood & Sterne, 2nd ed. 2004 - chapter on sample size determination The syllabus was confirmed by the faculty academic advisory committee to be valid September 2019-20

Last update: August 2019

9 2 Ben-Negev the of University Gurion Medical School for International Health

Name of the course: - 1 Number of course: 481-8-1010

BGU Credits: 2.5 Course Description: This Emergency Medicine course provides the student with the basic skills a physician needs in order to save lives in emergencies and in everyday situations. ECTS credits: The course will focus on basic resuscitation skills that are required for the trained care-giver in both pre- and in-hospital settings. Most of the studies will be conducted in small groups with a personal instructor. Academic year: 2019-20 Aims of the course: Teach basic concepts and techniques in first aid and emergency medicine. Semester: 1 Objectives of the course: 1. Recognize situations requiring CPR and provide Life Support at a high standard Hours of instruction: 52 of care using both basic and intermediate life support skills to adults, children and infants. 2. Recognize and provide emergency care on the pre-hospital and basic in- Location of instruction: TBA hospital level to a variety of emergency situations. 3. Provide emergency care to trauma patients in the pre-hospital arena to a high standard of care, perform basic rescue techniques and provide pre-hospital Language of instruction: English trauma life support. 4. Basic Emergency medical skills including: Use of a semi-auto external defibrillator, insertion of I.V. lines, backboard extrications and immobilizations, Cycle: 1st bag-valve-mask devices, airway management and more.

Learning outcomes of the course: Position: Mandatory course On successful completion of the course, the student should be able to:

Field of Education: MD 1. Preform high standard CPR using basic and intermediate life support skills in adults and Responsible department: MSIH 2. Manage scene and provide quality treatment in trauma scenarios 3. Identify and treat a variety of medical emergencies, acquire patient General prerequisites: None history and preform basic physical examination

Grading scale: Honors/High Pass/Fail Attendance regulation: Mandatory attendance. There may be an absence of justified reasons up to 20% of the course hours subject to the approval of the course coordinator.

Teaching arrangement and method of instruction: Lectures will be given to the entire class, exercises will be conducted in small groups of 6-9 students and will be focused on practical practice.

10 Ben-Negev the of University Gurion Medical School for International Health

Lecturer: Yarden Sela Assessment: 50% of the grade- Faculty written exam – multiple choice questions 50% of the grade - OSCE (Objective Structured Clinical Exam) Contact details: Each component must pass. Office phone: 050-9926168 Work and assignments: Email: [email protected] Students will be required to answer online assignments regarding the material learned in class/ home. Office hours:- Time required for individual work: Course evaluation: In addition to attendance in class, the students are expected to be familiar with the Debriefing at completion of the material learned in earlier lectures as to be prepared for exercises. course.

Confirmation: Course Content\ schedule and outlines: 9 sessions of 5 hours lecture + exercise, covering CPR, Medical emergencies and Last update: 07/2019 trauma patient care.

Course literature: BLS for providers, American Heart Association, 2016 2015 AHA Guidelines for CPR & ECC, American Heart Association 2018 Focused updates of the American Heart Association Guidelines for CPR & ECC PHTLS: Prehospital Trauma Life Support, 9th Edition 2019 , National Association of Emergency Medical Technicians (NAEMT)

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

11 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Endocrine System Number of course: 481-8-1005

BGU Credits: 4.75 Course Description: Aims of the course: ECTS credits: The endocrine system is the method by which the body communicates among its organs via messenger molecules. The course is an integrative course which will cover the anatomy, histology, Academic year: 2019-20 physiology, pathophysiology and pathology and treatment of endocrine disorders. Semester: 2 Objectives of the course: The intention of the course is to prepare the medical student to identify and treat Hours of instruction: 77 endocrine disorders through an integrative approach. Lectures: Learning outcomes of the course: On successful completion of the course, the Tutorials: student should be able to: Laboratories: 1. Describe the normal anatomy, histology and physiology of the major endocrine organs and systems including the pituitary, adrenal, thyroid Location of instruction: Faculty of glands, calcium and energy metabolism and normal growth process. Health Sciences classroom 2. Identify abnormal physical symptoms and signs and laboratory findings and to relate them to their respective pathologic syndromes and Language of instruction: English diseases. 3. Discuss the differential diagnosis of common endocrine disorders, Cycle: 1st specifically in the fields of pituitary, adrenal, thyroid, parathyroid, bone, growth, energy metabolism including diabetes mellitus and obesity. 4. Discern between primary, secondary and tertiary endocrine disorders Position: Mandatory System based on the clinical symptoms and signs and laboratory findings. 5. Recognize and diagnose multiple endocrine neoplasia and autoimmune Field of Education: MD syndromes, discuss their components and relationships. 6. Offer treatment plans for major endocrine disorders and diseases. 7. Reproductive endocrinology will not be discussed in this course. Responsible department: MSIH

General prerequisites: None Attendance regulation: Lectures – mandatory Grading scale: Honors/Pass/Fail Laboratories - mandatory

Teaching arrangement and method of instruction: Frontal lectures, case discussions, histology and pathology lab

12 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Jonathan Arbelle Assessment: Contact details : NBME test - 100%

Office phone : 050-9123007 Work and assignments:

Email: [email protected] Students are expected to review material guided by each teaching unit.

Office hours: To be announced at the first session Time required for individual work: Students are required to study and review the lectures at home - roughly 30 Course evaluation: minutes per an hour lecture. Online student survey and debriefing at completion of course Module Content\ schedule and outlines: Confirmation: The course starts out with lessons on hormonal action at the cellular and molecular level, and then is divided by the discrete endocrine systems: The hypothalamic-pituitary- target organ axis, anterior and posterior pituitary function; normal and pathologic growth and pubertal development; the thyroid gland; the adrenal gland, metabolism of calcium and bone, obesity and diabetes mellitus. Last update:

September 2019 Required reading: Part 16: Endocrinology and Metabolsm, Harrison's Princples of , 18 Ed, Dan L. Lingo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, Larry Jameson, Joseph Loscalzo, Eds.

Additional literature: Melmed: Williams Textbook of Endocrinolgy 12th ed (ebook on MDConsult) Both avalable through the BGU Medical library internet site.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 13 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Epidemiology Number of course: 481-8-1090

BGU Credits: 3 Course Description: ECTS credits: Aims of the course: A 52-hour introductory course of the principles and methods used in clinical Academic year: 2019-20 Epidemiological studies. Semester: 2 Since Epidemiology is the basic science of Public Health, which is a basic Hours of instruction: 52 component of International Health and Medicine (IMH), this course is given during the second semester of the first year as an essential introduction to IMH. Lectures: 26

Labs: Objectives of the course: Tutorials: 26 The course lectures cover the basic components of disease transmission, measures of morbidity such as incidence and prevalence and the various ways of Location of instruction: 6th Floor, Internal Medicine Bldg., measuring mortality, including survival analysis. Soroko Medical Center The principles of measuring the validity and reliability of diagnostic and screening tests are also taught. Language of instruction: The second part of the course deals primarily with study design, from randomized clinical trials to observational studies such as cohort, case-control, cross sectional English and ecological studies. The importance of evaluation studies is presented with Cycle: 1st regard to screening programs and health services research. Position: Mandatory course The problems that are studied through homework assignments as well as the Field of Education: problems studied through class exercises cover the course material and allow the MD students to cope with real life examples of topics such as investigation of a food Responsible department: borne outbreak, adjustment of mortality rates, etc. as well as to critically read epidemiological literature. MSIH General prerequisites: Learning outcomes of the course: On successful completion of the course, the Biostatistics student should be able to: 1. Understand and evaluate different measures of disease burden. Grading scale: 2. Understand and be able to evlaute screening procedures and their effectivness Pass/Fail/Honors 3. Know and be able to use different study designs, and evaluate the strength and weaknesses of each study design. 4. Using all of the above will be able to read and understand research articles and evaluate the strength and weaknesses of each article.

Attendance regulation: Lectures: Optional Exercises: Mandatory

Teaching arrangement and method of instruction: The course is composed of 26 hours of lectures. In addition, 24 hours of tutorials, 2 hours per assignment, are provided to assist students in solving these problems and deepen their understanding through class discussion. A final exercise is used to summarize the taught material.

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Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Ronit Ratzon Assessment: Contact details : Final test (made up Faculty written multiple choice questions as well as open- ended questions) 90% Office phone: Homework assignments: 10% Email: [email protected] Office hours: Wednesday after the Work and assignments: lecture. 10 Homework assignments Course evaluation: Epidemiology debriefing as scheduled by MSIH administration Time required for individual work: in addition to attendance in class, the students and the Epidemiology course are expected to do their assignment and individual work: It seems that tutorials coordinator. need an hour of solving the assignments, which means 20 hours per the whole course. Confirmation: The syllabus was confirmed by the faculty academic advisory committee to be valid 2018-19. Course Content\ schedule and outlines:

Last update: November 2018 Lectures: 1. Introduction & Disease Transduction 2. Measuring Morbidity and Mortality 3. Evaluation of Diagnostic and Screening Tests 4. Natural History of Diseases 5. Experimental Study Design 6. Cohort, Case Control and Cross-sectional Studies 7. Measuring Risks 8. Causal Infer. Bias, Interaction & Confounding 9. Evaluation of Screening Programs 10. Health Services Evaluation

Required reading: Epidemiology, Gordis 2004

Additional literature: Important articles from NEJM, JAMA and Lancet using or discussing epidemiological issues will be presented and a special section is devoted for reading scientific articles.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

15 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Genetics Number of course: 481-8-1038

BGU Credits: 2.5 Course Description:

Aims of the course: ECTS credits: The goal of the genetics course is to introduce and teach basic principles and practice in modern genetics. Academic year: 2019-20 Objectives of the course: Objectives are to establish basic understanding of the fundamentals of human Semester: 2 genetics with emphasis on relevance to clinical human genetics, genetic testing, and counseling.

Hours of instruction: 36 Learning outcomes of the course: On successful completion of the course, the Lectures: 23 student should be able to: Tutorials:13 1. Describe all inheritance modes 2. Analyze pedigrees from a variety of inheritance modes 3. Outline the mitosis and myosis processes including the DNA and Location of instruction: chromosomal content Faculty of Health Sciences classroom 4. Assess risk in genetics 5. Describe Mendelian concepts of inheritance, some representing Language of instruction: English Mendelian disorders and its implication in medical practice 6. Describe non-Mendelian concepts of inheritance, some representing non-Mendelian disorders and its implication in medical practice Cycle: 1st 7. Describe polygenic and multifactorial inheritance, some representing disorders and its implication in medical practice 8. Describe basic concepts in molecular genetics, mutation types, and Position: methods used in clinical diagnosis Mandatory system 9. Describe basic concepts of population genetics, allele frequencies, including Hardy-Weinberg 10. Describe genetics screening tests and strategies including common Field of Education: MD diseases as Fragile X, Cystic Fibrosis, Spinal Muscular Atrophy etc 11. Describe genetic screens for aneuploidy during pregnancy, Chorionic Villous Sampling, Amniocentesis, Karyotype implications, perinatal Responsible department: MSIH counseling, non-invasive prenatal diagnosis, pre-implantation genetic diagnosis/screening 12. Describe congenital malformation, the various types and developmental General prerequisites: None processes and factors involved creating malformation 13. Be familiar with the option of treatment in genetic diseases: personalized medicine and pharmacogenetics Grading scale: Honors/Pass/Fail 14. Be familiar with concepts of oncogenetics, oncogenetic syndromes and DNA damage repair processes and implication in practice 15. Discuss ethical issues in genetic counseling and testing

Attendance regulation: Lectures – optional

PBLs/clinical discussions - obligatory

Teaching arrangement and method of instruction: Frontal lectures Clinical discussions PBLs

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Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Assessment: Contact details : NBME - 90% Office phone: 640-3633 Mandatory submission of 5 out of 6 exercises (average grade) 10% Email: obirk @bgu.ac.il

Office hours : Work and assignments: To be announced at the first session. Students are required to take active part in PBLs and clinical discussions

Course evaluation: Time required for individual work: in addition to attendance in class, the students Online student survey and debriefing on completion of course are expected to do their assignment and individual work: Roughly one hour per hour of lecture.

Confirmation: Module Content\ schedule and outlines: 2019-20 The first lectures deal with basic cytogenetics, mitosis and meiosis, moving on to pathologies of chromosome number and structure, and the relevant clinical Last update: syndromes. June 2019 Mendelian inheritance is discussed, as well as non-Mendelian genetics (genomic imprinting, multifactorial diseases, expansion repeats and anticipation, etc.), linkage analysis, population genetics and risk assessment. The final part of the course deals with a short overview of cancer genetics, and then genetic screening tests, screening tests in pregnancy, and finally - pharmacogenomics and personalized medicine and a glimpse at clinical dysmorphology.

Lectures: 1. Clinical Cytogenetics 2. Mendelian Inheritance I 3. Risk assessment 4. Population Genetics 5. Non-Mendelian genetics 6. Gene Mapping 7. Cancer Genetics 8. Genetic Counseling & Prenatal Diagnosis 9. Pharmacogenetics, Personalized Medicine, Clinical Dysmorphology

Required reading: Medical Genetics by Jorde (Mosby - 2015) – in medical library Relevant text book chapters as assigned in the individual study units

Additional literature:

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

17 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Hebrew Beginners Number of course: 503-5-1063/52

BGU Credits: 0 Course Description: A study of modern Hebrew through a general approach to its lexicon, grammar ECTS credits: 0 and colloquial expressions

Aims of the course: Academic year: 2018-19 Developing primary knowledge and orientation in language skills

Objectives of the course: Semester: 1 & 2 To acquire the ability to use questions and answers for every day topics, to understand basic forms of speech and to perform most basic functions using the Hours of instruction: language, such as buying goods, telling the time, ordering food, asking for directions etc.

Location of instruction: Learning outcomes of the course: On successful completion of the course, the student should be able to: 1. Read and understand simple texts. Language of instruction: English 2. Write phrases and short paragraphs, mostly descriptions of day to day situations 3. Introduce himself / herself and describe in simple terms aspects of Cycle: 1st his/her background, immediate environment and situation. 4. Understand sentences and frequently used expressions related to areas Position: Mandatory course for non- of most immediate relevance (e.g. very basic personal and family Hebrew speakers information, shopping, local geography, traveling). 5. Communicate with native speakers of Hebrew within a basic level

Field of Education: Medicine Attendance regulation: Class attendance is mandatory. Homework, attendance, short tests and final test are the base for calculating final Responsible department: MSIH grades.

General prerequisites: Teaching arrangement and method of instruction: The course will be conducted in small classes and will consist of class discussions, exercises, texts, watching Israeli videos & films.. Grading scale: Honors/Pass/Fail Reading and writing tasks will be assigned for homework twice a week. Syntax and grammar levels will be adapted to suit student ability.

Assessment: Composition of Final Course Grade: 1. Participation & homework 33.33 % 2. Quizzes during the term 33.33 % 3. Final Exam 33.34 % 100 %

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Ben-Gurion University of the Negev Medical School for International Health

Coordinator: Ms. Sofia Birkan Work and assignments: Homework constitutes integral part of studying process. Reading and writing tasks will be assigned for homework twice a week Teachers: Time required for individual work: Ms. Sofia Birkan In addition to attendance in class, the students are expected to watch TV in Ms. Michal Dekel Hebrew, videos on the net, have conversations with Israeli students.

Office phones: Course Content \ schedule and outlines:

שם העצם ושם התואר :Emails התאמת התואר לשם סמיכות Office hours: שם המספר תואר הפועל Course evaluation: הפועל Debriefing at completion of the זמן הווה, זמן עבר, זמן עתיד לבניינים הבאים : course פעל, פיעל, הפעיל, התפעל, נפעל Confirmation: July 2019 ציווי בפעלים שגורים בניין פועל, בניין הופעל – מילים בודדות הקשורות לתחום הרפואה מילות שאלה Last update: July 2019 מילות יחס בנטייה מבעים חשובים ) מבעי התנצלות, מבעי הבעת דעה, מבעי בקשת מידע וכולי ( מונחים מתחום הרפואה

Required reading:

Course Textbook : "עברית לרפואה, א" / עדנה לאודן, אביבה חיים ) צומת ספרים (

Additional Instructional materials:

Worksheets

19 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Hematology System Number of course: 481-8-1023

BGU Credits: 5.75 Course Description: Aims of the course: ECTS credits: The Hematology system aims to reflect the advances made in biology and medicine in recent years. Some of these include the actual isolation of the multi- Academic year: 2019-20 potential stem cell and the discovery of new growth factors regulating cell proliferation and differentiation.

Semester: 2 Objectives of the course: Objectives of the course are to provide the student with an understanding of: Hours of instruction: 81

 Biology of Hematopoiesis Location of instruction: Faculty of  Physiology of WBC, RBC, Platelets Health Sciences classroom  Pathology of Hematopoiesis Language of instruction: English  Hemostasis  Transfusion medicine Cycle: 1st Learning outcomes of the course: On successful completion of the course, the Position: Mandatory system student should be able to: 1. Describe normal peripheral smear and bone marrow findings and Field of Education: MD correlate these to pertinent laboratory tests used to evaluate hematologic disorders 2. Classify red blood cell disorders (anemias) and apply laboratory values in Responsible department: MSIH clinical decision making 3. Describe the coagulation cascade, pertinent laboratory tests used to assess coagulation function and correlate with diseases of coagulation General prerequisites: None dysfunction 4. Define thrombocytopenia and distinguish between qualitative and Grading scale: Honors/Pass/Fail quantitative platelet disorders; formulate a differential diagnosis based on clinical findings and laboratory date 5. Classify white blood cell disorders (leukemia, lymphoma and multiple myeloma) and compare pathologic features of each category 6. Apply clinical laboratory and ancillary molecular diagnostic testing to develop a differential and a diagnosis of white blood cell disorders

Attendance regulation: Lectures – mandatory Labs - mandatory PBLs and prep sessions – mandatory as a clinical activity

Teaching arrangement and method of instruction: Frontal lectures, groups, histo-pathological laboratories. Computer labs will also be used.

20 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Anat Rabinovich Assessment: Contact details: NBME test and faculty written multiple choice test

Office phone Work and assignments: Email: [email protected] Preparation of case and group discussions Office hours: Time required for individual work: in addition to attendance in class, the students TBA at first lecture are expected to do their assignment and individual work: Students are required to study and review the lectures at home - roughly 30 Course evaluation: minutes per an hour lecture. Online student survey and debriefing at completion of course. Course Content\ schedule and outlines: Lectures: Confirmation: 2019-20 1. Red Blood Cells – Structure and Function 2. Hematopoesis & Aplastic Anemia Last update: 3. Introduction to Anemia 4. Enzymopathies January 2019-20 5. Autoimmune Hemolytic Anemia 6. Hemmoglobinopathies 7. Iron Metabolism 8. B-12 and Folate Deficiency 9. Blood Groups 10. Use of Blood Components 11. Transfusion Transmitted Diseases 12. Introduction to Leukemia 13. ALL 14. CMPD +CML 15. Stem Cell 16. FACS 17. AML 18. MDS 19. Multiple Myeloma 20. Introduction to Lymphoma 21. Non Hodgkin's Lymphoma 22. Hodgkin's Lymphoma 23. Chemotherapy 24. Coagulation system and tests 25. Congenital Bleeding Disorders 26. Platelets Disorders Quantitative 27. Platelets Disorders Qualitative 28. Anti Coagulation Drugs 29. DIC

21 2 Ben-Gurion University of the Negev Medical School for International Health

Required reading: 1. Harrison’s, Principles of Internal Medicine. 18th ed. 2012; Part 2- hematologic alteration: Chapter 57 anemia,polycitemia pp 448-457 Chapter 58 bleeding,thrombosis pp 457-464 Part 7 -Hematopoietic Disorders: Section 2, pp844-958, Disorders of hemostasis : Section 3, pp 965-988 2. Essential Haematology. A.V.Hoffbrand and J. S. Pettit.6th ed. 2011 Blackwell Scientific Publications. 3. Mechanisms in Hematology. L.G. Israels and E.D. Israels (provided with CDs). 4. Hematology: Pathophysiologic basis for clinical practice. S.H. Robinson and P.R/ Reich.

Websites: The educational site of the American Society of Hematology (ASH): http://www.ashimagebank.org/cgi/co, or http://www.bloodline.net/ ; Select: Image Atlas, 2) http://www.ashteachingcases.org/ and the ASH site: http://www.hematology.org/education/teach case/ for case reviews

Additional literature: Additional reading: as provided by teachers

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

22 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Histology Number of course: 481-8-1018

BGU Credits: Course Description: 3 Aims of the course: ECTS credits: The goals of the Histology course are to:  Provide the students with the basic skills necessary to identify and understand the properties of human tissues including their organization, Academic year: 2019-20 function and microscopic appearance. Semester:  Present the basic histological techniques used to prepare and study the 1 microscopic structure (substructure) of cells, tissues and organs.  Lay the basic foundation of knowledge for understanding the histology Hours of instruction: 48 of organs and systems as will be studied in the second year. Lectures: 26 Tutorials: Objectives of the course: Laboratories: 22 Recognition of specific tissues and organs and understand the link between structure and function on the cellular and tissue levels. In addition, students will develop expertise identifying histological features. Location of instruction: Faculty of Health Sciences classroom Learning outcomes of the course: On successful completion of the course, the Language of instruction: student should be able to: English 1. Identify all basic tissues 2. Analyze a histological slide to identify the tissue properties Cycle: 1st 3. Demonstrate a clear understanding of the link between structure and Position: Mandatory course function of tissues Field of Education: MD Attendance regulation: Lectures – optional Responsible department: Labs - mandatory MSIH

General prerequisites: Teaching arrangement and method of instruction: None Frontal lectures, lab sessions, self-study. Grading scale:

Honors/Pass/Fail Assessment: U.S.-style Multiple Choice Test (60%) Practical exam (30%) 10 Weekly laboratory quizzes (10%)

Work and assignments: Laboratory attendance and quizzes throughout the semester

Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: reading the relevant text book chapters and analyzing the slide preparations available to them via the internet. Due to the method of the course, students are required to study and review the lectures at home. Roughly 30 minutes per hour lecture plus about 2 hours per laboratory session.

23 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Module Content\ schedule and outlines: Prof. Michal Hershfinkel 1. Introduction, Tools and Methods of Study Dr. Noam Levaot 2. Peripheral blood 3. Epithelia and Glands 4. Connective tissue Contact details : 5. Striated muscle Office phone: 6. Smooth muscle, Cardiac muscle, Blood vessels 7. Bone and cartilage 08-6477318 8. Essential organization of the nervous system Email: [email protected] 9. Respiratory Office hours: 10. Lymph and spleen TBA at first lecture 11. Gastrointestinal tract 12. Kidney and urinary system Course evaluation: Online student survey and debriefing at completion of course Required reading: 1. MH Ross, LJ Romrell, GI Kaye. Histology – A Textbook and Atlas. Confirmation: 2019-20 2. Junquierra, Basic Histology

Last update: September 2019 Additional literature:

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

24 2 Ben-Gurion University of the Negev Faculty of Health Sciences, Medical School for International Health (MSIH)

Name of the course: Immunology Number of course: 481-8-1019

BGU Credits: 3.0 Course Description : The immune system in health and disease Academic year: 2019-20 Semester: Autumn semester Aims of the course: To describe the immune system and explain how it contributes to health and disease. Hours of instruction: Sundays 8:45am-10:00am 10:15am-11:30 am Objectives of the course: To understand the molecular and cellular bases of the Class sessions: Total 20 hours immune response

Location of instruction: Learning outcomes: Faculty classroom On completion of the course, students should be able to:

Language (instruction and exam): 1. Describe the cellular and molecular mechanisms involved in immune English response to infection. 2. Explain the molecular and cellular mechanisms underlying diseases caused by deficiencies in components of the immune system. Cycle: 1st 3. Explain the consequences of immune hyper-reactivity.

Position: Classes include: Mandatory course Organization of the immune system, innate immunity, antigen recognition, lymphocyte development, adaptive immune responses to infection, Field of Education: MD hypersensitivity, autoimmunity, immune deficiencies, transplantation, cancer.

Responsible department: MSIH (via Attendance regulation: Dept. of Clinical Biochemistry & Optional. However, 20% of the grade is from in class case studies. Pharmacology)

General prerequisites: Teaching arrangement and method of instruction: Cell biology The course will primarily be a “flipped” classroom. The students will complete assignments to prepare for class. Class sessions will use a team- based learning approach to acquire a deeper knowledge of the immune system and to apply Grading scale: basic concepts to clinical scenarios. Honors/Pass/Fail

25 Ben-Gurion University of the Negev Faculty of Health Sciences, Medical School for International Health (MSIH)

Lecturer: Prof. Deborah Lebman Assessment: Office (Dept.) phone: 1. Completion of pre-class quizzes 15% Email: [email protected] 2. In class case studies 20% 3. NBME exam 65% Office hours: Book by e-mail ____ Office location: 100% Work and assignments: Pre-class quizzes. Before each class, students will complete an open book quiz to Course evaluation: ensure readiness for class. At the end of the semester the students will evaluate the course in In class problems. During class students will work in groups to solve problems order to draw constructive related to clinical scenarios. At the end of each class, the group will hand in answers that will be graded. conclusions, and for the university’s internal requirements Final exam. The final exam will be held at the end of the course. The exam is comprised of 50-70 multiple choice questions, of which at least half are patient- Confirmation: case oriented and require familiarity with basic clinical terminology. The format is computer-based in accordance with USMLE; the duration is calculated as 90 The syllabus was confirmed by the seconds per question. faculty academic advisory committee to be valid from July Class Sessions: 2019 1. Overview of the Immune System 2. Innate Immunity Last update: July 2019 3. Antigen Recognition: T and B Cell Receptors 4. Antigen Recognition: Processing of Ligands for T Cells/MHC 5. Lymphocyte Development 6. Adaptive Immune Responses to Infection 7. Immune Response at Mucosal Surfaces/ Pathogen Evasion of the Immune Response 8. Hypersensitivity 9. Autoimmunity and Immune Deficiency Diseases 10. Transplantation and Cancer

Required reading: The Immune Response to Infection, Deborah Lebman An interactive, electronic textbook (tophat.com). The pre-class assignments will be in this format.

Case Studies in Immunology (7th Edition), Raif Geha and Luigi Notarangelo

Pre-class reading and quizzes will be available on tophat.com. Case studies will be available on the course page.

26 Course title: Introduction to basic research techniques in the basic sciences for medical students

Course # 481-8-9065

General Information Course Details

Credits: 2.5 Course Description: Introduction to the biomedical research laboratory and common research tools used.

Aim of course: Provide knowledge and understanding of various research Academic Year: 2019-20 techniques and approaches used in biomedical research. To advance understanding of how a research laboratory can serve as a practical setting for the verification of a research hypothesis. Semester: 2nd Course implementation: Course will be divided into both theoretical/frontal lecture approach as well as "hands on" bench work setup according to the course schedule. Duration: 4 hours/week Course Outline:

First week:

A. Introduction to the course and how it will be implemented. Number of participants: 8 Emphasis on the structure of course and basic course requirements.

B. Introduction and background to scientific research Location: Research laboratory in Medical This will include:

Faculty.  A screening of the various models used in research and their advantages/disadvantages: Cells, Tissue, animal models and isolated systems such as biochemical methods using purified proteins.  Basic important terms: false positive, negative control, positive Language: English control, double blind etc.  From the research lab to the clinic and vice versa: Research starting on the bench and culminating in clinical trials or alternatively, Degree: MD understanding the biological mechanism of a clinical manifestation  Introduction to practical/bench work that will be conducted in the course. Students will be introduced to the concept of how a clinical Course Head: Dr. Joy Kahn. phenomenon can raise questions leading to basic research. They will be presented with a clinical manifestation and together we will raise questions and a hypothesis regarding the biological mechanisms that may be involved. These research questions will serve as the basis for all the practical laboratory work and we will Lecturer: Dr. Joy Kahn utilize various laboratory techniques/tools to answer these questions.

27 Contact info:  Clinical research versus basic science.

Tel: 0547464233 Lab sessions (Week 2-12): Email: [email protected] One week prior to meeting, students will be referred to reading material Field of Education: MD which will be mandatory for preparing them for the upcoming laboratory.

Responsible department: Structure of meeting: The Medical School for International Health.  Biological question and hypothesis leading to use of specific technique. General prerequisites:  Introduction to the lab technique to be learned that week: Eg: Cloning of a gene of interest for protein expression in cells. None  Understanding the rationale behind use of the specific technique and Grading scale: the necessary theory needed for understanding the methodology.  Students will be given a worksheet of the lab assignment to guide Honors/Pass/Fail them through the laboratory work of the particular session which we will go over together.  Students will be divided into pairs (4 groups of 2 each)  With the guidelines of the worksheet and in my presence students will then complete the lab assignment on a practical level.  Session will be briefly summarized.  Students, in pairs will be required to hand in a brief written report presenting the aims, materials and methods, results and conclusions of the lab sessions.

Concluding Lecture/Final Week: This will be presented by 2 researchers:  An MD/Ph.D., a clinician who will share his personal career path, and the different challenges and requirements in pursuing this direction.  A Ph.D. senior scientist who focuses on basic scientific research. He will present his career history, his research and the advantages and disadvantages in this career choice. Time will be left for questions.

Assessment: Laboratory reports Teacher’s evaluation

Work and assignments: Summarizing the entire project at the end of the course

1. Firs

28 Name of the course: Introduction to Global Health and Medicine 2018-2019 Number of course: 481-8-1070 Fall Semester

BGU Credits: 1.5 Course Description ECTS credits: Aims of the course: Academic year: 2018-19 This course aims to equip students with critical perspectives and context Semester: 1 they will need as clinicians in resource-poor settings, and as global citizens in our increasingly small and interdependent world. Hours of instruction: 19 hours Objectives of the course: Location of instruction: TBD Language of instruction: The introduction to global health course will familiarize students with broad topics in global health, exploring social determinants of global English health and global disease burden, and selected areas such as child Cycle: 1st survival and vaccine-preventable diseases, Ebola, Zika virus, HIV/AIDS, tuberculosis, and malaria,. The course will provide a historic context to Position: Mandatory course global health, and focus on topical global health issues. We will Field of Education: MD emphasize how we must view health problems as global wherever they occur. We will also stress the importance of looking for solutions to Responsible department: health problems as potentially coming from low and middle (LMIC) to MSIH high income countries (HIC), and we will address the more traditional view that HICs can solve LMIC health problems. General prerequisites: Successful completion of all prior courses Learning outcomes of the course: On successful completion of the course, the student should: Grading scale: 1. Recognize social determinants of global health and disease burden 2. Understand the historic context to global health and topical GH issues Honors/Pass/Fail 3. Be able to address solutions to health problems 4. Understand the importance of the local context, and how it fits with Lecturers: the global perspective 5. Be familiar with the literature related to global health from scientific Prof. Mark Katz publications and journals Dr. Anat Rosenthal Prof. Carmi Margolis Attendance regulation: Mandatory

Teaching Assistants: Teaching arrangement and method of instruction: Dan Weksler Derri Teaching methods will combine interactive lectures and ‘flipped classroom’ techniques with case-based exercises. In addition students will give brief presentations on topical subjects. Because much global health work requires a skilled approach to teamwork and coalition building, exercises and evaluations will focus in part on group activities. Efforts will be made to expose students to potential role models in global health clinical practice and global health research.

29 Contact details: Assessment: 40% individual presentation Emails: 40% group presentation – final project [email protected] 20% class attendance and participation [email protected] [email protected] Work and assignments: [email protected] Individual presentation: each student will choose a topic related to global health and deliver an 8-10-minute presentation followed by a 5-7 minute discussion on the subject. Course evaluation: Honors/Pass/Fail Group presentation: For a final project, students will be split into 5-6 groups. Each group will be tasked with making a pitch in order to solicit Office hours: TBD funding for a global health intervention. The pitch will involve an oral Confirmation: 2019-20 presentation of no more than 12 minutes. Last update: Summer 2019 Time required for individual work: In addition to attendance in class, the students are expected to read the relevant materials listed in the syllabus in order to be prepared for each session.

Course Content\ schedule and outlines: See below

Required reading:

(See course schedule) Additional literature:

1. Introduction: What is Required reading: Global Health? (Sept. 9, 1. Jeremy Green, “Chapter 3. Colonial Medicine and Its Legacies” in 2019) “Reimagining Global Health.” Paul Farmer, Arthur Kleinman, Jim Kim, Matthew Basilico. California Series in Public Anthropology.

Additional reading 2. Frenk, J., and S. Moon. Governance Challenges in Global Health. New England Journal of Medicine. 2013.368(10):936-942.

30 3. Nicole Szlezak et al., January 2010, “The global : actors, norms, and expectations in transition,” PLoS Medicine, Volume 7, Issue 1, e1000183 (4 pages) 4. Jeffrey Kluger, January 22, 2015, “What the Gates Foundation has achieved, 15 years on,” TIME, http://time.com/3678405/gates- foundation-annual-letter/ 2. Global Burden of Disease Case study: 4 cases from the Social Medicine course at Harvard Medical and Social Determinants of School. Health (September 25, 2019) Required: 1. Social Determinants of Health Inequalities.” Lancet, 2005; March 19- 25; 365:1005-6. 2. Hans Rosling, 2006, “TED Talk: the best stats you’ve ever seen,” http://www.ted.com/index.php/talks/hans_rosling_shows_the_best_stat s_you_ve_ever_seen.html (19 minutes) Suggested: 1. The Strawberry Capital of the World is the early death capital of the U.S.: lessons from a landmark dataset. Washington Post. September 14, 2018. https://www.washingtonpost.com/business/2018/09/14/wrong- neighborhood-can-take-plus-years-off-your-life- average/?utm_term=.971eea0d9132

2. Jones, D et al. The Burden of Disease and the Changing Task of Medicine. New England Journal of Medicine. 2012.

3. Epidemics and Pandemics Case study: It’s Potluck -Who’s Bringing the Salmonella? (October 2, 2019) .No need to read the case study in advance, we will go over it in class*

Required: 1. Laurie Garrett, Sept/Oct 2015, “Ebola’s lessons – how the WHO mishandled the crisis,” Foreign Affairs, https://www.foreignaffairs.com/articles/west-africa/2015-08- 18/ebola-s-lessons?campaign=Garrett (brief online article) 2. Nurith Aizenman, “Threats By Text, A Mob Outside The Door: What Health Workers Face In The Ebola Zone.” NPR.org. Accessed July 29, 2019. https://www.npr.org/sections/goatsandsoda/2019/05/10/721020887/th reats-by-text-a-mob-outside-the-door-what-health-workers-face-in-the- ebola-zon. Additional: 3. Bobbie Person et al., February 2004, “Fear and stigma: the epidemic within the SARS outbreak,” Emerging Infectious Diseases, Volume 10, Issue 2, pp. 358-363 (5 pages) 4. Hooker, L. Claire, et al. 2014 Don't be scared, be angry: the politics and ethics of Ebola. The Medical journal of Australia 201(6):352-354.

31 5. Doctors Fear Zika Is A Sleeping Giant In Haiti. National Public Radio, Morning Edition. August 31, 2016. http://www.npr.org/sections/goatsandsoda/2016/08/31/4920926 26/doctors-fear-zika-is-a-sleeping-giant-in-haiti 6. Claire, P. (2019) WHO declared the Ebola outbreak in Congo a global health emergency. Here’s what that means. Washington Post - https://www.washingtonpost.com/world/2019/07/18/who-declared- ebola-congo-global-health-emergency-what-does-that-actually-mean/ 4. Non-communicable Case Study: Tam WJ, Yap P. Health care for older persons in Uganda: Diseases Lessons for the developing world. J Am Geriatr Soc. 2017 Jun;65(6):1358- (October 28, 2019) 1361. doi: 10.1111/jgs.14560. Epub 2016 Oct 22.

Required: 1. Haileamlak, A. (2018). The Ethiopia Noncommunicable Diseases and Injuries (NCDI) Commission Report Summary: Addressing the Impact of Noncommunicable Diseases and Injuries in Ethiopia. NCDI Commission, Ministry of Health, Ethiopia: 40.

Additional: 1. Clarfield, A. M., & Rosenthal, A. (2017). Aging in Sub‐Saharan Africa: Sub‐par?. Journal of the American Geriatrics Society, 65(6), 1136-1138.

5. HIV/AIDS Case study: The Academic Model for the Prevention and Treatment of (November 11, 2019) HIV/AIDS Peter Park, Arti Bhatt, Joseph Rhatigan

Required: 1. Brandt, A. M. 2013. How AIDS Invented Global Health. New England Journal of Medicine 368(23):2149-2152. 2. Hans Rosling. Insights on HIV, in stunning data visuals. Ted Talk. 2009. Additional: V .1 e l l a ,

6. When Global Health is Case study: Working today to narrow the gaps of tomorrow. pp 1-11 & Local: The Israeli Healthcare 20-23. System and Health Issues in the Negev (Nov 18, 2019) Required reading: 1. Filc, D. and Davidovitch, N. Rethinking the private–public mix in health care: analysis of health reforms in during the last three decades.

32 Journal of Health Services Research and Policy. June 2016 http://hsr.sagepub.com/content/early/2016/06/21/1355819616650470. abstract. 2. Clarfield, AM. Health and Health Care in Israel: An Introduction. Lancet. May 2017

Additional reading: 1. Israel: Health System in Review. Health Systems in Transition. Vol. 17 No. 6 2015 http://www.euro.who.int/__data/assets/pdf_file/0009/302967/Israel- HiT.pdf?ua=1 2. Treitzer-Goltzman Y, and Peleg R. Health and morbidity among women in southern Israel: a descriptive literature review of the past two decades. J Community Health. 2014 Aug; http://www.ncbi.nlm.nih.gov/pubmed/244929

33 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Introduction to Oncology Number of course: 481-8-1063

BGU Credits: 2 Course Description: Aims of the course: ECTS credits: Introduction to the treatment of patients with cancer.

Objectives of the course: Academic year: 2019-20 1) Explore the molecular basis of cancer and how that understanding impacts on treatment. Semester: 2 2) Learn the approach to framing the goals of treating the individual patient: curative, palliative or something in between. Hours of instruction: 21 3) Study the basics of cancer chemotherapy, including immunotherapy. 4) Learn about surgical oncology and the importance of multidisciplinary care in cancer treatment. Location of instruction: 5) Introduce the basic principles of radiation therapy. Internal Medicine Building – 6) Learn about the profession of radiation oncology and the training for it. 7) Explore biologic and personalized therapy of cancer. Language of instruction: English 8) Introduction to hospice and palliative care 9) A look at cancer treatment in the developing world 10) Consider the financial burden of cancer therapy. Cycle: 1st 11) Present a series of ethical dilemmas in cancer care. 12) Examine some of the psychological aspects of oncology. Position: Mandatory course 13) Show the process of cancer treatment from the patient’s point of view. 14) Present examples of complementary medicine in cancer care

Field of Education: MD Learning outcomes of the course:

Responsible department: MSIH On successful completion of the course, the student should be able to: 1. Define what cancer is on a molecular level. 2. Know the difference between curative and palliative cancer care. General prerequisites: 3. Know when radiotherapy can be useful and how it works 4. Know when chemotherapy can be useful and some of the mechanism of actions of drugs. Grading scale: Honors/Pass/Fail 5. Understand what is meant by biologic and personalized therapy. 6. Analyze various ethical dilemmas that occur in patient care in oncology and propose solutions. 7. Identify the different medical and paramedical specialists needed to give comprehensive care including hospice and palliative care. 8. Know about types of complementary medicine that can be useful in oncology patients 9. Be aware of the challenges of costs of cancer care and of delivering cancer care in the developing world. 10. Know about the profession of radiation oncology and the training pathways to enter the field.

34 1 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Prof. D. Geffen Attendance regulation: Required

Assessment: Presentation and discussion Contact details: Office phone : 054-4699731 Teaching arrangement and method of instruction:  Lectures  Small group discussions Email: [email protected]  Group/individual presentations

Office hours: By appointment via email Time required for individual work:

In addition to attendance in class, the students are expected to do read at least 2- 3 journal articles and discuss with their small group members how to present the article(s) to the rest of the class. Course evaluation: Evaluation form to be filled out.

Course Content\ schedule and outlines: Confirmation: 2019-20 Day 1: 1. The Science and the Practice of Oncology Last update: November 2018 2. Patient Interview: 3. Surgical Oncology 4. Radiation Oncology- 5. Medical Oncology-

Day 2: 6. Palliative medicine and hospice care 7. The Art of Oncology 8. Applied molecular biology: Personalized cancer therapy I 9. Applied molecular biology: Personalized cancer therapy II  Psyco-oncology-

Day 3: 10. Integrative medicine 11. Oncology priorities in countries with limited resources and the financial toxicity of therapy 12. Cancer drug development and the pharmaceutical industry 13. Radiation Oncology and Radiation Oncologists 14. The patient’s point of view: Doctor- patient and doctor-doctor communication

Required reading: Articles to be sent to the students before the course.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

35 2 Ben- Gurion University of the Negev The Medical School for International Health Course: Introduction to Patient Interview in Hebrew Course # 481-8-1045

Number of course: BGU Credits: 1 Course Description: ECTS credits: The Clinical Interview in Hebrew”. This theme is aimed at focusing the rudiments Academic year: of Hebrew acquired in the first semester course towards “Clinical Hebrew”, whilst exposing the student to the patient interview as a 2019-20 technique. This course along with the 2nd year “Communication and physical Semester: examination skills” course is designed to teach each medical student the basic 2nd semester clinical skills needed for medical practice. These skills include effective communication, scheme‐based history taking, physical examination, formation of Hours of instruction: 26 an initial diagnostic plan, interpretation of basic diagnostic studies and articulate Monday - 16:00- 18:00 clinical case presentation.

Location of instruction: Aims of the course: 1 .Soroka University Medical Center The primary aim is to develop clinical interview skills by re-organizing the 2. Dichman Building, faculty of health information acquired in layers, from the early stages of basic sciences, through sciences Ben-Gurion University clinical sciences to “systems”, and applying it to patient interactions. This course will serve as the foundation for the 2nd year “Communication and physical examination skills” course. Language of instruction: English Objectives of the course: Hebrew 1. Provide the ability to perform a skilled and efficient basic clinical interview. 2. Integrate clinical Hebrew skills into the clinical interview. Cycle: 1st 3. Communicate effectively with patients and families across a broad range of socioeconomic and cultural backgrounds 4. Communicate with sensitivity, honesty, compassion and empathy. Position: Mandatory course Learning outcomes of the course: Field of Education: On successful completion of the course, the student should be able to: MD 1. Perform a basic clinical interview in Hebrew/English Responsible department: 2. Use a wide clinical Hebrew vocabulary, MSIH 3. Communicate using language that is clear, understandable, and appropriate to each patient. General prerequisites: 1st semester Hebrew Language Courses Attendance regulation: Attendance is compulsory and the course is assessed by means of TAs’ Grading scale: evaluations Personal TA evaluation

36 Ben- Gurion University of the Negev The Medical School for International Health

Lecturers: Teaching arrangement and method of instruction: Ron Charach MD, MHA A series of 12 weekly sessions throughout the second semester of the first year. Contact d etails: Students will meet together for each two‐hour session in the hospital wards. The students will be divided into learning groups according to Hebrew language Phone: +972-54-800-6778 proficiency. Students begin by practicing interviews in English before Email: ch [email protected] implementing Hebrew skills.

Demonstrations and practice with interview skills will be principally carried out in Dvir Gatt MD small groups supervised by Tas’. Debriefing and feedbacking will be following each Contact details: learning encounter. Phone: +972-54-800-6778 Assessment: Email: [email protected] Personal TA evaluation(s): 100%

Work and assignments: Every year in the first meeting, the class is introduced with the general instructions and assignments of the course. Group assignments are given individually by TA's Office hours: Days and hours when according to the group level. the lecturer and\or assistant are Time required for individual work: available at the office for the In addition to attendance in class, the students are expected to do their students. assignment and individual work: 3-4 weekly hours . Course evaluation: Required reading: Course booklet On-line Feedback Additional literature: No

Confirmation: The syllabus was confirmed by the faculty academic advisory committee to be valid on Aug 2019

Last update: August 2019

* All learning material will be available to the students on the course’s website Moodle/ library/ electronic documents available to BGU students.

37 Ben- Gurion University of the Negev Faculty of Health Sciences

Name of the module: Medical Ethics Number of module: 481-8-1080

BGU Credits: 1 Course Description: ECTS credits: Aims of the module: The goal of the module is to introduce students to the discipline of medical ethics Academic year: 2018-19 Objectives of the module: Objectives are to enable students to identify the various ethical issues that arise in the practice of medicine and analyze them from Semester: First semester different ethical perspectives including principlilism, casuistry, relational and religious. Hours of instruction: Learning outcomes of the module: On successful completion of the course, the Lectures, case studies and videos student should be able to:

1. Identify ethical issues in the practice of medicine Location of instruction: 2. Analyze the issues from different ethical perspectives Lectures wil take place in the 3. Define euthanasia, passive euthanasia and physician assisted suicide Deichmann Building for Health 4. Understand the financial incentives that can cause ethical conflicts in the Professions. Specific classroom practice of medicine numbers are indicated in the 5. Describe the unethical behavior of Nazi physicans and its impact on the schedule. development of the Helsenki code 6. Analyze the ethical arguerments for and against artificial reproduction Language of instruction: and abortion Lectures will be given in English. 7. Understand the various laws relating to medical ethics that are relevant in Israel and contrast them to laws in othe countries including the Patients-Rights law, Abortion, Terminal Patient Law and the Brain Death Cycle: 1st Law Position: Mandatory course 8. Define Professionalism and how it relates to the physician 9. The ethics of triage 10. Ethical issues in global medicine e.g. risk taking and allocation of scarece Field of Education: Ethics/MD resources

Responsible department: Attendance regulation: Attendance to all sessions of the course is mandatory. Center for Medical Ethics, Soroka University Medical Center. Teaching arrangement and method of instruction: Instruction in the module is based on frontal oral lectures, case based discussions, videos General prerequisites:

Grading scale: Pass/Fail

38 Ben- Gurion University of the Negev Faculty of Health Sciences

Lecturer: Prof Alan Jotkowitz Assessment: Contact details : Students will be assessed by attendance in the course 0503331585 Work and assignments: Students are required to participate in the classroom Email: [email protected] discussions and do the assigned readings

Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: Course evaluation: At the end of the semester the Module Content\ schedule and outlines: students will evaluate the course, in 1. To be a physician order to draw conclusions, and for the university's internal needs 2. Ethical responsibility of the student 3. Physician-Patient Communication 4. Medical Ethics Confirmation:

2019-20 Required reading: Students are expected to read the lectures as presented as ppt presentations.and the supplementary readings. Last update: 6/2019

1. SM Glick. From Arrowsmith to the House of God, or "Why Now?" Am ] Med 1990; 88: 449-51 (editorial) 2. L van Winkle. The Complete Physician 3. Responsibility for integrity lies first with students: J.C. Jennings, Albert Einstein College of Medicine, Yeshiva University 4. - 2 pages from The Death of Ivan Ilyich by Tolstoy which presents a classic example of alienation between physician and patient. - Letter to a Patient's Doctor. Ann Int Med. 129: 333, 1998 - The Medical Student as Patient. Ann Int Med. 131: 225,1998 - When You Come Into My Room. lAMA. 276: 512,1996 5. - Leo Alexander. Medical Science Under Dictatorship. N Engl J Med 1949; 241: ·39-47 - Beachamp and Walters 2nd Ed. Major Ethical Principles. Contemporary Issues in Bioethics - Bernard La. Skepticism About Medical Ethics. Resolving Ethical Dilemmas: A Guide for Clinicians

*All learning material will be available to the students on the module's website (high-learn)/ library/ electronic documents available to BGU students

39 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Microbiology - 1

Number of course: 481-8-1012

BGU Credits: 4 Course Description: ECTS credits: Microbiology is an integrative course, reflecting the complexity of microbiology Academic year: 2019-20 today. Its main goal is to furnish the student with sufficient background knowledge for understanding the origin of infectious diseases, the biology of Semester: 1 disease-causing organisms, identification methods, and approaches to the control Hours of instruction: of microbial growth. The first semester includes Bacteriology. 1st Semester The sessions in this courser will be divided into frontal, standard lectures and Lectures: 39 case discussion lessons. Laboratories: 26 The case discussion lessons will be preformed on the basis of clinical case presentation, and a review of the theoretical background through the cases. This way of learning requires intense and committed pre-session reading, in order Location of instruction: Faculty of to be prepared for the clinical discussion. Health Sciences classrooms A list of required reading from the course's text book "Medical Microbiology" by Murray will be published. Language of instruction: English Because of the cooperative nature of the case-discussion sessions, attendance in these classes will be mandatory, and each class will begin with a short quiz which Cycle: 2nd degree will cover only the material of the following class (from the previous self reading requirements). Position: Basic science course. A In addition, the course contains practical laboratories where students acquire passing mark is obligatory for basic knowledge on the methods currently used for the identification and students in the MD program. characterization of the main human pathogens.

Field of Education: Medicine

Aims of the course: Responsible department: MSIH The purpose of the course is to expose the students to the world of microbiology and infectious disease. General prerequisites: None Objectives of the course: Grading scale: Honors/Pass/Fail Teaching methods utilize frontal lectures and practical laboratories where students acquire basic knowledge on the methods currently used for the identification and characterization of the main human pathogens.

40 Ben-Gurion University of the Negev Medical School for International Health

Coordinator: Learning outcomes of the course: On successful completion of the course, the Dr. Yael Yagel student should be able to:

Lecturer: 1. Recount the basic principles of microbiology, including microbial Dr. Yael Yagel physiology and genetics, antibiotics, host-parasite relationships, and epidemiological concepts. Contact details

Office phone: 2. Discuss the ways in which bacteria cause disease in human and animals, Email: [email protected] antibiotic treatment, antibiotic resistance and the mechanisms involved. Office hours: To be announced at 3. Perform basic laboratory assays for the identification of a pathogen. first session.

Attendance regulation: Course evaluation: Yearly debriefing Case discussion meetings- mandatory Labs – mandatory Confirmation: The syllabus was confirmed by the faculty academic Assessment: advisory committee to be valid on August 2019 Bacteriology Quizzes: There will be 8 quizzes, but only 6 will count for the final grade- the highest and lowest scores will not be included 60% Final exam: 40% Last update: August 2019

Work and assignments: Self-study of designated material before each case discussion.

Time required for individual work: In addition to attendance in class, the students are expected to do their assignment and individual work: Reading, lab-related work, and material review are estimated requiring 3-4 hrs/wk.

Required reading: Medical Microbiology, Murray.

* All learning material will be available to the students on the module's website (Moodle)/ library/ electronic documents available to BGU students. 41 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Microbiology - 2 Number of course: 481-8-1011

BGU Credits: 3.5 Course Description: Aims of the course: Microbiology is an integrative course, reflecting the complexity of microbiology ECTS credits: today. Its main goal is to furnish the student with sufficient background knowledge for understanding the origin of infectious diseases, the biology of Academic year: 2019-20 disease-causing organisms, identification methods, and approaches to the control of microbial growth. The course includes topics from several disciplines such as bacteriology, virology, parasitology and mycology. Semester: 2

Objectives of the course: Hours of instruction: Teaching methods utilize frontal lectures and practical laboratories where Lectures: 39 students acquire basic knowledge on the methods currently used for the Laboratories: 13 identification and characterization of the main human pathogens. The second part of the course includes:

Location of instruction: Part 2 – Virology, Parasitology, Mycology Faculty of Health Sciences classrooms One day will be dedicated entirely to AIDS including the structure of HIV, virus- host interactions, immunopathology of AIDS and AIDS-associated diseases. Language of instruction: English

Learning outcomes of the course: Cycle: 2nd On successful completion of the course, the student should be able to: 1. Identify viral, parasitic and fungal pathologies Position: Mandatory course 2. Understand the lifecycles 3. Know basic pharmacology fo antivirals, fungus and parasitic agents Field of Education: Medicine

Attendance regulation: Responsible department: MSIH Lectures: Mandatory Labs: Mandatory General prerequisites: 1st cycle 481- Exam content will be taken from all the following: 8-2012  Powerpoint presentations  Class reading materials Grading scale: Honors/Pass/Fail  Oral presentations from the lecture

Teaching arrangement and method of instruction: An integral set of frontal lectures in a classroom setting, laboratory training and laboratory assignments should be submitted by the students.

42 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Yael Golan Assessment: 6 quizzea – 50% Contact details: NBME exam and faculty written question: 50% Office phone :

Email: golany860 @gmail.com Work and assignments: Clinical case presentation/lab reports Office hours: To be announced at the first session Time required for individual work: Reading, lab-related work, and material review are estimated requiring 3-4 Course evaluation: hours/week. Required reading will be assigned and/or during each class. Debriefing at completion of all selectives.

Required reading: Medical Microbiology, Murray. Confirmation: The syllabus was confirmed by the faculty academic advisory Course content committee to be valid on August 2019 1. Virology: a. Introduction to virology Last update: August 2019 b. Influenza and Parainfluenza Viruses c. Other viruses causing respiratory infections d. Hemorrhagic Fever – SELF STUDY e. Hepatitis A, E f. Hepatitis B, C, D – SELF STUDY g. B-19 – SELF STUDY h. Gastroenteritis – SELF STUDY i. Retrovirus Replication and Human UTI j. Herpes Viruses – SELF STUDY k. CNS Viruses including Rabies l. Laboratory 2. Parasitology: a. Intestinal and urogenital protozoa b. Apicomplexa c. Haemoflagelates d. Nematoda (round worms) e. Trematoda and Cestoda 3. Mycology a. Common mycotic infections b. Fungal pathogens c. Cutaneous fungal infections d. Student presentations

Required reading:

Medical Microbiology: Murray

* All learning material will be available to the students on the module's website (Moodle)/ library/ electronic documents available to BGU students.

43 2 Ben-Gurion University of the Negev Medical School for International Health Name of the course: Molecular and Cell Biology Number of course: 478-8-1042

BGU Credits: 5 Course Description: Aims of the course: ECTS credits: To convey to the students how genetic information and its processing in the cell affect health and how our abilities to measure them are changing diagnosis and therapy. Academic year: 2019-20 Objectives of the course: At the cellular level, molecular trafficking across membranes (passive and active Semester: 1 transport, Phagocytosis, pinocytosis and receptor mediated endocytosis), targeting (endoplasmic reticulum and lysosomes, protein secretion and Hours of instruction: 74 membrane targeting) and the involvement of the cytoskeletal components (microfilaments, microtubules and intermediate filaments) in these and other cellular processes will be considered. We will also explore the molecular bases of Location of instruction: protein degradation (eg. ubiquitination), programmed cell death (apoptosis) and Faculty of Health Sciences classrooms cancer progression (oncogenes and tumor suppressor genes).

Language of instruction: English At the molecular level, we explore the use of information by the cell and show how aberrations or changes in cell information content and its processing are associated with phenotypic variation and disease. We will show how the basic Cycle: 1st elements of information processing in the cell have become key tools in diagnosis (PCR, polymorphism screening, expression analysis). We will demonstrate how advances in reading and decoding the human genome offer prospect for better Position: Mandatory course diagnosis and therapy.

Field of Education: MD Course Content: Modules are separated into Cellular and Molecular topics. Within these two subdivisions, the material will be presented in the order shown below. However, Responsible department: MSIH contents from one subdivision will be interspersed with content from the other.

General prerequisites: None Learning outcomes of the course: On successful completion of the course, the student should be able to: Grading scale: Honors/Pass/Fail 1. Understand the basic structure/function basis of organelle activity 2. Demonstrate clear understanding of the basic cellular lifecycle 3. Understand and remember the molecular mechanisms involved in information propagation, processing, and change in the cell. 4. Discuss the ways in which these processes differ between prokaryotes and eukaryotes. 5. Understand how variation and changes in genetic information can affect phenotype and health. 6. Appreciate the integration of the molecular biological machinery and methodologies into medical procedures of diagnosis. 7. Discuss some future directions with respect to molecular biology and diagnosis or therapy.

44 Ben-Gurion University of the Negev Medical School for International Health

Course Coordinators: MOLECULAR BIOLOGY Content (See next page for outline): Molecular Biology: Dr. C. Davis Cellular Biology: Prof. J. Gopas • This part of the course focusses on how the cell deals with genetic information. Basic pathways are covered in the first, largely self-study, Teachers: modules of the course. The course then moves to consider in more detail Prof. J. Gopas the mechanisms and implications of change and variation in the human Dr. C. Davis genome on health and disease. Finally it finishes by showing how the fast- Dr. I. Rostovsky developing technologies of molecular biology are changing the practice of diagnosis and perhaps, in the future, therapy. Contact details: Office phone: CELL BIOLOGY Content (See next page for outline): Prof. Gopas: 08-6477253 Dr. Davis: 054 465 8407 • Membranes structure and function • Trans-membranal transport • Endocytosis Email: • Cytoskeleton: microfilaments, Microtubules, Intermediate filaments Prof. J. Gopas: [email protected] • Protein sorting: Endoplasmic reticulum and Golgi apparatus Dr. C. Davis: [email protected] • Mitochondria Dr. I. Rostovsky: • Protein degradation: Ubiquitin [email protected] • Programmed cell death apoptosis • Biology of Cancer Office hours: Ad hoc - as arranged through email or Moodle Assessment: Course evaluation: Cellular Biology: 35% Online student survey and debriefing Multiple-choice NBME test at the end of semester 1. Molecular Biology: 65% Confirmation: 25% Quiz marks The syllabus was confirmed by the 75% Multiple-choice final exam - Lecturer-constructed. faculty academic advisory committee to be valid 2019-20 Time required for individual work: in addition to attendance in class, students are Last update: expected to do assigned self-study, assignments, PBL work, and quizzes. July 2019 Students are required to study and review lectures at home (30mins/hour lecture)

Required reading: Molecular Biology: Molecular Biology of the Cell (Alberts) 6th Edition 2015 • Additional material in Moodle and course web site.

Cell Biology: The Cell: A Molecular Approach 6th Ed. Cooper & Hausman

• Relate to the Key Experiment and Molecular Medicine vignettes as well as the relevant summary and key terms at the end of the Chapter. • Similar material can be studied from other editions of the same textbook. • Power Point presentations on each of the subjects are available in Moodle

45 Ben-Gurion University of the Negev Medical School for International Health

Course Outline:

MOLECULAR BIOLOGY: • Introduction: Course structure and Learning tools (Frontal) • Rash diagnosis and discussion. (PBL, WIKI-based with final discussion. This module runs the length of the course.) • The Molecular Biology Core (These modules are mostly self-study with associated quiz and tutorial) • DNA and Replication (Self-study, quiz, tutorial) • Transcription (Self-study, quiz, tutorial) • Translation (Self-study, quiz, tutorial) • Gene Regulation (Self-study and frontal, quiz, tutorial) • DNA damage and repair (Self-study, quiz, tutorial) • Recombination (Frontal, quiz, tutorial) • Recombinant DNA technology (Self-study, quiz, tutorial) • Challenge: Make fluorescent E.coli (Exercise and frontal discussion) • The Human Genome in sickness and health • Genome geography (Self-study, quiz, tutorial) • Meaning in the genome (Frontal - discussion) • Genome variation and its consequences (Frontal, quiz, tutorial) • DNA diagnostics (Frontal, quiz, tutorial) • Challenge: Diagnoses - gene known, gene unknown (Exercise and frontal discussion) • Genome Pathology: Cancer and diagnostics tools (Self-study, quiz, tutorial) • Challenge: primary tumor identification (Exercise and frontal discussion) • PBL conclusion (Frontal - discussion) • The future. Big data, disease, and gene therapy (Frontal - discussion).

CELL BIOLOGY:

 Lecture 1: Cytoskeleton (1)  Lecture 2: Cytoskeleton (2) Chapter 12. The Cytoskeleton and Cell Movement. Pp 459-472, 482-490, 496-512  Lecture 3: Protein Sorting and Transport (1) Chapter 10. Protein Sorting and Transport- The Endoplasmic Reticulum, Golgi Apparatus and Lysosomes. pp 373-419.  Lecture 4: Self-study subjects:  Chapter 2. The composition of cells. Cell membranes pp 58-64.  Chapter 13. The plasma membrane. Pp 514-531, 537-539. Molecular Medicine page 541-554. Endocytosis. pp 544-553. Chapter 11. Bioenergetics and metabolism. Mitochondria- pp 421-425 and Molecular Medicine (Diseases of Mitochondria-pp 426-427).  Lecture 5: Protein Sorting and Transport (2)  Lecture 6: Self-study (complete self-study material of lecture 4 and see movie)  Lecture 7: Chapter 8-Protein degradation (ubiquitin-proteosome). Pp 335-341 Chapter 17. Cell death (apoptosis). Pp 682-692  Lecture 8: Cancer (1) Chapter 18. Cancer pp713-723, 727-757  Lecture 9: Cancer (2)

46 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: On Being a Doctor 1&2 Number of course: 481-8-1055/1056

BGU Credits: 4 Course Description: Aims of the course: Introduction to a selection of the many personal, ECTS credits: interpersonal and societal issues surrounding the practice of medicine. Objectives of the course: Academic year: 2019-20 1) Identify positive physician behavior worthy of emulation. 2) Appreciate the value of continuity of care in medicine. 3) Appreciate the power that physician’s words have on patients. Semester: 1st & 2nd 4) Learn important aspects of the economics of health care. 5) Learn some important psychologic concepts: Nature, nurture, first Hours of instruction: 52 adaptations, attachment, temperament , understanding adult thinking , sexual history and confidentiality 6) Identify both the benefits and conflicts of interactions with medical Location of instruction: related industry and how to deal with the conflicts. Faculty of Health Sciences classrooms 7) To gain insight into the approach to the dying patient and to the family after the patient’s death. 8) Start to be prepared for integrating professional and personal life. Language of instruction: English 9) Appreciate the value of older colleagues and how to relate to younger students and colleagues. Cycle: 1st 10) To consider the doctor’s health and well being 11) To think about when the doctor becomes the patient 12) To discuss issues in humanistic professionalism Position: Mandatory course 13) To anticipate ethical dilemmas 14) Learn how to approach and treat patients with disabilities Field of Education: MD 15) Learn from a long time practicing gastroenterologist lessons from practice and how to deal with friends becoming patients.

Responsible department: MSIH Learning outcomes of the course: On successful completion of the course, the student should be able to General prerequisites: None 1. Articulate and remember the positive behaviors of physicians. 2. Articulate and remember the value of continuity of care and the long Grading scale: Pass/Fail term influence of physicians on their patients and visa versa. 3. Understand many of the challenges facing both patients and doctors in dealing with the cost of health care. 4. Identify conflicts of interests when dealing with the health related industry and some techniques for navigating them. 5. Better manage the dying patient and behavior toward the family after the patient’s death. (continued on last page) 6. How to better manage the balance between personal and professional life. 7. Be more comfortable in working with colleagues of all ages. 8. Have the psychologic framework for a better understanding of patient behavior

Attendance regulation: Attendance is mandatory

Teaching arrangement and method of instruction: Team based learning, frontal presentations, journal articles to read prior to class. 47 1 Ben-Gurion University of the Negev Medical School for International Health

Lecturers: Prof David Geffen Assessment: Guest lecturers (so far): Class participation. Presentation of articles. Dr. Michael Weinstock, Mandatory attendance Psychology( BGU)

Prof David Chinitz, Health and Time required for individual work: in addition to attendance in class, the students Economics (Hebrew University are expected to do their assignment and individual work: School of Public Health) Most work will be done in class. Most weeks there will be 1 or more short articles Dr. Judah Goldman, Emergency physician and ethicist (Sharei Zedek to read before class. Hospital ) Module Content\ schedule and outlines: Dr. Jennie Goldstein, practicing psychiatrist (Israel) (First semester) 1. What I wished my doctor would have said/not said, done/not done. Dr. William R. Stern, practicing 2. The power of words and continuity in medicine. gastroentereologist (USA) 3. Health Economics Ms. Tsvia Shapiro-Wajsberg, Israel 4. Physicians and the pharmaceutical/ medical equipment industries. Human Rights Center for People 5. Psychosocial aspect of practicing medicine from a psychologist’s point of view with Disabilities (4 session sub-module , Dr. Michael Weinstein, instructor). 6. Managing the dying patient- the movie “Wit” Rabbi Etan Geffen, Clinical 7. After a patient dies what should the physician do? psychologist (Israel) 8. Balancing personal and professional life and obligations. 9. Relationships with colleagues, older and younger.

Course Coordinator: (Second semester) Prof. David Geffen 10. “What am I doing in THIS seat?” When the doctor becomes the patient. 11. Caring for the Carer: First Do No Harm … To yourself Contact details: 12. Humanistic professionalism 13. Ethical dilemmas Office phone: 054-4699731 14. Friends as patients and other lessons learned from clinical practice. Email: [email protected] 15. How to approach and treat patients with disabilities 16. Sexual abuse and other sexuality issues in practice 17. Have the psychologic framework for a better understanding of patient Office hours: by appointment behavior Course evaluation: 18. To be prepared to handle ethical dilemmas and make appropriate decisions. Online student survey and debriefing 19. To be able to care for people with disabilities in an appropriate manner at the end 20. To be able to discuss with patients matters of sexuality and recognize sexual abuse Confirmation: 21. To be able to handle personal illness as a physician and to be aware of The syllabus was confirmed by the personal well being practices. faculty academic advisory committee to be valid for academic Required reading: required articles will be placed on Moodle the week before each year 2019-20. session.

Textbook: Last update: July 2019

Additional literature: Much of the course will be based on the series of articles in the Annals of Internal Medicine, entitled “On Being a Doctor”

48 2 Name of the course: Pathology Number of course: 4881024

BGU Credits: 2.75 Course Description: Aims of the course: ECTS credits: Students should understand the molecular and cellular mechanisms of disease, and how those mechanisms translate into the clinical presentation and lab results of the patient. The course will focus on general pathology: that is, how all human Academic year: 2019-20 tissues in general become diseases (eg, respond to injury or become cancerous), as opposed to systems pathology (the differences between how specific organs respond to injury or become cancerous, aka “second year of medical school”). We Semester: 2 will also cover systemic disease - those diseases which affect the entire body.

Hours of instruction: Objectives of the course: ● To lay the groundwork for the recurrent themes of systems pathology ● To give the basic tools for understanding the significance of terms Location of instruction: frequently used in surgical pathology reports Faculty of Health Sciences classrooms ● To help understand the consequences and the risks for complications when tissues suffer lethal or non-lethal injuries

Language of instruction: English Learning outcomes of the course: The student should be able to describe and recognize the evolution of disease in Cycle: 1st terms of etiology, pathogenesis, molecular / cellular / morphologic abnormalities, and clinical manifestations of the following general and systemic processes: Position: Mandatory course 1. Cell injury, death, and adaptations 2. Acute and chronic inflammation Field of Education: MD 3. Tissue renewal, repair, and regeneration 4. Hemodynamic disorders 5. Diseases of the immune system Responsible department: MSIH 6. Neoplasia 7. Congenital (genetic and fetus-injury) disease General prerequisites: Successful 8. Pediatric disease completion of all prior courses 9. Environmental and nutritional disease 10. Infectious disease

Grading scale: Attendance regulation: Honors/High Pass/Pass/Fail Lectures - optional, unless otherwise specified in advance that a required quiz or group activity will be taking place. Labs - mandatory

Teaching arrangement and method of instruction -Frontal lectures (some of which will be prepared by the students) -Laboratories -Group assignments

Time required for individual work: In addition to attendance in class & labs, the students are expected to do their assignments and individual work: Roughly 30 mins/hour of corresponding lecture and lab, plus additional time for entirely self-study topics

49 Lecturers: Assessment: Course Coordinator s: Laboratory + In-class quizzes: 10% Dr. Benzion Samueli NBME test: 90% Contact details : Course Content and Required Reading [email protected] The final exam is composed of multiple choice questions provided by the NBME. As such, any material that the NBME (read: USMLE) finds “testable” is liable to come Office hours : TBA up on the exam, that corresponds to the first nine chapters of “Robbins Basic Pathology, Tenth Edition” (in the course referred to as “RBP”). The lectures, labs, and self-study material will follow this content: Course evaluation: Online student survey and debriefing 1. The Cell as a Unit of Health and Disease at the end 2. Cell Injury, Cell Death, and Adaptations 3. Inflammation and Repair Confirmation: 4. Hemodynamic Disorders, Thromboembolism, and Shock The syllabus was confirmed by the 5. Diseases of the Immune System* faculty academic advisory 6. Neoplasia committee to be valid Sept 2019 7. Genetic and Pediatric Diseases 8. Environmental and Nutritional Diseases 9. General Pathology of Infectious Diseases** Last update: September 2019

*For this course, students will not be asked about anything from the sections titled Autoimmune Diseases, Rejection of Transplants, or Immunodeficiency Syndromes. Those will be left entirely for other courses. **At most, the exam will have just a very small number of questions from the concepts most heavily emphasized in RBP / Robbins and Cotran Review of Pathology / my lecture notes.

RBP covers the vast majority of relevant pathology material for the NBME. However, some topics are not covered in sufficient depth, and I will try to point those out as much as possible. The next “level up” is “Robbins and Cotran Pathologic Basis of Disease, Ninth Edition” (“PBD,” first 10 chapters) and for the most part covers significantly more depth than students need to know, but it does fill the RBP gaps quite nicely. Both RBP and PBD are available online for free via BGU library services at clinicalkey.com

Some lectures contain references to Up To Date articles. The referenced articles are recommended reading. Recommended practice materials include: ● Robbins and Cotran Review of Pathology ● Lippincott's Illustrated Q&A Review of Rubin's Pathology ● Any other question bank of USMLE style questions you can find ● Lab references ● Lab 1 - Chapter 2: Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death ● Lab 2 – Chapter 3: Inflammation and Repair ● Lab 3 – Chapter 4: Hemodynamic Disorders, Thromboembolic Disease, and Shock ● Lab 4&5 – Chapter 7: Neoplasia ● Lab 6 – Chapter 8: Infectious Diseases ● Lab 7 – Gaucher disease (Chapter 5), Necrotizing enterocolitis (Chapter 10), Meconium ileus (Chapter 10), Celiac Disease (chapter 17), HIrschsprung disease (Chapter 17) 50 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Pharmacology an earlier or an earlier or Number of course: 481-8-1022

BGU Credits: 3.5 credits. Course Description: ECTS credits: The course introduces the fundamental mechanisms and principles of drug Academic year: 2019-20 action, including the parameters that affect and determine the optimal use of drugs in a specific patient/population. These are intended to serve as a sound Trimester: 2nd. basis for the future long lasting involvement of the students with clinical Hours of instruction: according to the pharmacology. The emphasized topics of this course are: academic schedule. Pharmacokinetics – The absorption, distribution, metabolism and excretion of drugs, including factors such as genetic variability or disease states that may Location of instruction: affect the pharmacokinetics. Faculty of Health Sciences classroom Pharmacodynamics – Scientifically-based mechanisms of drug action. These Language of instruction: English. are taught as interactions of a drug with human physiological systems and pathological factors that lead to pharmacological effects. Cycle: 1st. Specific detailed examples of common and important mechanisms of drug Position: Mandatory course. action will focus on drugs that affect the activity of the autonomic nervous Field of Education: MD system, autacoids, antibiotics and chemotherapy. Responsible department: MSIH and Clinical Biochemistry and Aims of the course: Pharmacology. To acquire basic knowledge of pharmacology for different groups of drugs and of the processes governing drug action and use. General prerequisites: none. Grading scale: Objectives of the course: Honors/Pass/Fail. To learn basic scientific concepts and principles that will serve as the foundation for understanding the pharmacology of specific drugs. To understand the pharmacology and clinical use of several classes of clinically-important drugs. Course Coordinator: Prof. David Stepensky Learning outcomes of the course: On successful completion of the course, the 08-6477381 student should be able to: [email protected] • To understand the fundamental scientific principles of drug action and the Office hours: will be set in various mechanisms by which drugs can mediate their pharmacological effect. coordination with the students. • To understand the fundamental principles of pharmacokinetics that underly the absorption, distribution, metabolism and elimination of drugs in the body and thereby affect drug effectiveness. Lecturers: • To get acquainted with the common serious side effects of drugs and with Prof. David Stepensky mechanisms of drug toxicity. Prof. Sigal Fleisher-Berkovich • To recognize that drugs have action at different systems, to be able to group drugs with common pharmacological actions, and appreciate that this classification is not absolute. Assistant teacher: • To understand the pharmacology and clinical use of several classes of Sagi Shashar clinically-important drugs and to be sufficiently prepared to gather information on new drugs.

Teaching arrangement and method of instruction: Frontal lectures, pre-recorded lectures, homework assignments, interactive discussions of case studies, classroom tutorials and quizzes.

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Ben-Gurion University of the Negev Medical School for International Health

Course evaluation: Attendance regulation: A student debriefing will be  Frontal lectures – optional. Pre-recorded lectures – not needed. undertaken at the completion of the  Interactive discussions of case studies, classroom tutorials and quizzes – course. mandatory (80%).

Confirmation: the syllabus was confirmed by the Faculty Academic Assessment: Advisory Committee to be valid on  Short quiz at the beginning of each interactive discussion of case studies – no 2019-20 academic year. grade.  Quizzes – 30% of the total course grade (10% x 4 quizzes – lowest score Last update: August 2019 dropped).  NBME shelf test/faculty multiple choice test – 70% of the total course grade.  Students must receive passing grades for the test itself (NBME/Faculty test) and after combining the test and the quizz grades.

Time required for individual work at home:  1-2 hr before each frontal lecture: for reading the accompanying textbooks (see the required reading below).  3-4 hr before each in-class activity (interactive discussion of case studies, classroom tutorial or quiz): for viewing the pre-recorded lectures, reading the accompanying textbooks (see the required reading below) and preparing the homework assignments.

Recommended literature: Basic & Clinical Pharmacology, Katzung, 14th ed. 2018, or an earlier or later edition. Lippincott's Illustrated Reviews: Pharmacology, 7th ed. 2018, or an earlier or later edition. Rang & Dale's Pharmacology, 9th ed. 2019, or an earlier or later edition.

Required reading for the individual topics: 1. Introduction, General Characteristics of Drugs, Pharmacological Terms, Development of Drugs. Katzung, chapters 1 and 5. 2. Pharmacokinetics and Pharmacodynamics. Rang & Dale's, chapters 8-11. 3. Pharmacodynamics: Receptor Principles and Signal Transduction. Katzung, chapter 2. 4. Introduction to ANS (autonomic nervous system). Katzung, chapter 6. 5. ANS, Cholinergic Agonists, Direct & Indirect. Katzung, chapter 7. 6. ANS, Cholinergic Antagonists. Katzung, chapter 8. 7. ANS, Adrenergic Agonists and Sympathomimetics. Katzung, chapter 9. 8. ANS, Adrenergic Antagonists. Katzung, chapter 10. 9. Autacoids: Histamine, Serotonin, Angiotensin II, NO, Prostaglandins, NSAIDs, COX Inhibitors. Katzung, chapters 16-19. 10. Antibiotics (Antimicrobial therapy). Katzung, chapters 43-46. 11. Cancer Chemotherapy. Katzung, chapter 54.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 52

Ben-Gurion University of the Negev Medical School for International Health

Date/ Week Classroom Mandatory Type of activity Title Lecturer's name Time Unit 1. Introduction, Pharmacokinetics, Pharmacodynamics Introduction, General Characteristics Week 1 6XX, 6th floor N Frontal lecture Prof. D. Stepensky of Drugs, Pharmacological Terms. 6XX, 6th floor N Frontal lecture Pharmacokinetics: Introduction Prof. D. Stepensky Pharmacokinetics: Quantitative 6XX, 6th floor N Frontal lecture Prof. D. Stepensky Parameters (a) Pharmacokinetics: Quantitative 6XX, 6th floor N Frontal lecture Prof. D. Stepensky Parameters (b) Case study Week 2 6XX, 6th floor Y Pharmacokinetics Prof. D. Stepensky discussion Pre-recorded Pharmacodynamics, Receptor - N Prof. D. Stepensky lecture Principles Pre-recorded Pharmacodynamics, Signal - N Prof. D. Stepensky lecture Transduction Case study Week 3 6XX, 6th floor Y Pharmacodynamics Prof. D. Stepensky discussion 6XX, 6th floor Y Tutorial Tutorial 1. PK & PD Prof. D. Stepensky 6XX, 6th floor Y Quiz + review Quiz 1. PK & PD Prof. D. Stepensky Unit 2. Autonomic Nervous System (ANS) Pre-recorded - N Introduction to ANS Prof. D. Stepensky lecture Pre-recorded - N ANS, Cholinergic Agonists Prof. D. Stepensky lecture Pre-recorded N ANS, Cholinergic Antagonists Prof. D. Stepensky lecture Case study 6XX, 6th floor Y ANS, Cholinergic Prof. D. Stepensky discussion Pre-recorded - N ANS, Adrenergic Agonists Prof. D. Stepensky lecture Pre-recorded - N ANS, Adrenergic Antagonists Prof. D. Stepensky lecture Case study 6XX, 6th floor Y ANS, Adrenergic Prof. D. Stepensky discussion 6XX, 6th floor Y Tutorial Tutorial 2. ANS TA Sagi 6XX, 6th floor Y Quiz + review Quiz 2 TA Sagi Unit 3. Autacoids 6XX, 6th floor N Frontal lecture Autacoids – part 1 Prof. Fleisher-Berkovich 6XX, 6th floor N Frontal lecture Autacoids – part 2 Prof. Fleisher-Berkovich Pre-recorded - N Autacoids- Clinical Aspects Prof. D. Stepensky lecture Case study 6XX, 6th floor Y Autacoids Prof. D. Stepensky discussion 6XX, 6th floor Y Tutorial Tutorial 3. Autacoids TA Sagi 6XX, 6th floor Y Quiz + review Quiz 3. Autacoids TA Sagi Unit 4. Antibiotics & Chemotherapeutic Drugs

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Ben-Gurion University of the Negev Medical School for International Health

Pre-recorded - N Antibiotics – General Principles Prof. D. Stepensky lecture Pre-recorded - N Antibiotics – Clinical Aspects Prof. D. Stepensky lecture Case study 6XX, 6th floor Y Antibiotics Prof. D. Stepensky discussion Pre-recorded - N Principles of Chemotherapy Prof. D. Stepensky lecture Pre-recorded Cancer Chemotherapy – Drug - N Prof. D. Stepensky lecture Groups Case study 6XX, 6th floor Y Cancer Chemotherapy Prof. D. Stepensky discussion Tutorial 4. Antibiotics & 6XX, 6th floor Y Tutorial TA Sagi Chemotherapeutic Drugs Quiz 4. Antibiotics & 6XX, 6th floor Y Quiz + review TA Sagi Chemotherapeutic Drugs 6XX, 6th floor N Q&A review before the exam Prof. D. Stepensky Final exam. Details TBA by Ilana 6XX, 6th floor Y Prof. D. Stepensky Shub, [email protected]

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Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Physiology

Number of course: 481-8-1006

BGU Credits: 2 Course Description: ECTS credits: The Basic Physiology course will focus on four levels: cellular, tissues, organs, and Academic year: 2019-20 systems.

Aims of the course: Semester: 2 The goal is to understand the relationship between structure and function and to create a basis for understanding the activity of organs and systems.

Hours of instruction: Objectives of the course: Lectures: 18 A comprehension of fundamental physiology which will form the basis for the Tutorials: study of “clinical systems” next year.

Learning outcomes of the course: On successful completion of the course, the Location of instruction: student should be able to: Faculty of Health Sciences classroom 1. Know basic physiology principals. 2. Understand the different body systems function. Language of instruction: English 3. Understand systems functions integration.

Cycle: 1st Attendance regulation: Position: Mandatory course Lectures - optional

Field of Education: MD Teaching arrangement and method of instruction: Frontal lectures and PBL sessions Responsible department: MSIH

Assessment: General prerequisites: NBME test: 90% Basic course in chemistry and physics 4 mandatory quizzes: 10% Quiz 1: Endocrinology. Grading scale: Pass/Fail/Honors Quiz 2: GI Quiz 3: Quiz 4:

Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work:

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Ben-Gurion University of the Negev Medical School for International Health

Coordinator: Course Content\ schedule and outlines: Gal Ben Arie, PhD Teachers: 1. Intro. to Human Physiology: Concept of Homeostasis Dr. Gal Ben Arie 2. Physiology Osmosis & Body Fluid Shifts, Hyper & Hypo Osmotic States 3. Physiology Problem workshop: Indicator-Dilution Measures and Fluid Dr. Alon Kaplan Shifts 4. Physiology Clinical Case Discussion: Aminata’s Swelling & Diarrhea Contact details: 5. Endocrine physiology 6. GI physiology Office phone: 7. Nervous system physiology Email: [email protected] 8. Renal physiology [email protected] 9. Respiratory physiology

Required reading: Office hours: TBA 1. Textbook of Medical Physiology (by Guyton & Hall, eleventh edition). 2. Vander's Human Physiology (twelfth edition). Course evaluation: 3. * Please note that the lectures order is not according to the textbooks’ Online student survey and debriefing chapters order. at end of course 4. Relevant Chapters 5. Textbook of Medical Physiology by Guyton & Hall (eleventh ed.) Confirmation: 6. Chapter 4: Transport of Substances Through the Cell Membrane August 2019 7. Chapter 5: Membrane Potentials and Action Potentials 8. Chapter 6: Contraction of Skeletal Muscle 9. Chapter 7: Excitation of Skeletal Muscle - Neuromuscular Transmission Last update: and Excitation-Contraction Coupling Aug 2019 10. Chapter 45: Organization of the Nervous System, Basic Functions of Synapses, “Transmitter Substances” 11. Chapter 54: Motor Functions of the Spinal Cord; the Cord Reflexes 12. Chapter 55: Cortical and Brain Stem Control of Motor Function 13. Chapter 60: The Autonomic Nervous System and the Adrenal Medulla 14. Chapter 62: General principales of gastrointestinal function 15. Chapter 63: Propulsion and mixing of food in the alimentary tract 16. Chapter 66: Physiology of gastrointestinal disorders 17. Chapter 64: Secretory functions of the alimentary tract 18. Chapter 65: Digestion and absorption in the gastrointestinal tract 19. Chapter 66: Physiology of gastrointestinal disorders 20. Chapter 74: Introduction to endocrinology 21. Chapter 75: Pituitary hormones and their control by the hypothalamus 22. Chapter 76: Thyroid Metabolic hormones 23. Chapter 77: Adrenocortical hormones 24. Chapter 78: Insulin, glucagon and Diabetes mellitus 25. Chapter 79: Parathyroid hormone, calcitonin, calcium and phosphate metabolism, vitamin D, bone and teeth 26. Vander's Human Physiology (twelfth ed.) 27. Chapter 12: Cardiology system 28. Chapter 13: Respiratory system 29. Chapter 14: Nephrology system

*All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 56 2 Global Health Modules

57 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Health Inequities – Local and International Perspectives Number of course: 481-8-2014

BGU Credits: 1 Course Description: This course explores the issue of health inequalities and health inequities. It provides an opportunity to examine contemporary interpretations of health inequalities and related concepts like such as justice and ECTS credits: equity. The course discusses how different approaches to measuring, defining and monitoring health inequalities are influenced by social and political factors Academic year: 2019-20 and how this, in turn, shapes strategies for addressing such inequalities

Aims of the course: to provide theoretical and application tools for medical Semester: 1 students in order to develop interventions to reduce health inequities.

Objectives of the course: Hours of instruction: 13 Become knowledgeable of the current research on health disparities and health inequities Location of instruction: TBA Become knowledgeable on the underlying cause of health inequalities and inequities Be able to identify, describe, and be knowledgeable regarding possible solutions Language of instruction: English to address/reduce health inequalities in different populations

Learning outcomes of the course: Cycle: 1st On successful completion of the course, the student should be able to: 1. recognize the various existing frameworks regarding health inequities Position: Elective module 2. asses empirical evidence, outcome measurement issues, policy and policy formation concerns regarding health inequities Field of Education: MD 3. develop interventions to reduce health inequities

Attendance regulation: Attendance in the course is mandatory. Students that will Responsible department: MSIH miss class are required to inform the instructor prior to class. Missed classes are acceptable under the school regulations (sickness, emergency, etc). Student will General prerequisites: present a short paper showing a basic understaning of the course material of the class they missed. Student that will miss more than one class will be removed from the course. Grading scale: Honors/Pass/Fail Teaching arrangement and method of instruction:

Lectures, group discussions, exercises, student presentations

Assessment: 50% Presentation preparation and presentation 50% Group activity and written assignment

Work and assignments:

1. Students will read the literature and present an intervention to reduce health inequities within a specific context using a power point presentation. Active presentation will be provided to evaluators and peers in the class 2. Students will participate in the group activity and develop an intervention design to reduce health inequities. The intervention planning will be submitted as a written assignment. 58 1 Ben-Gurion University of the Negev Medical School for International Health

Lecturers: Nadav Davidovitch, Time required for individual work: In addition to attendance in class, the students are expected to read materials, Dani Filc participate in class and group discussions, present in class. Contact details Office phone : 08-6477421 Course Content\ schedule and outlines:

Email: [email protected], Meeting 1: [email protected] Health inequities – definitions, frameworks (e.g. SES, culture and ethinicity). 2 Case studies (Israel and global(

Office hours: by appointment Meeting 2: Measuring health inequities; identifying responsible bodies and stakeholders Course evaluation: Debriefing at completion of all selectives. Meeting 3: Inequities within and between countries; interventions for reducing health Confirmation: 2019-20 inequities; exercise in small groups: Building interventions

Last update: 2019-20 Meeting 4: Students presentations and discussion, course summary

Required reading:

General Comment No. 14 on the right to the highest attainable standard of health, UN Doc. E/C.12/2000/4 Marmot, Michael, et al. Closing the gap in a generation: health equity through action on the social determinants of health. Lancet 2008; 372: 1661-1669.

Kumagai AK, Lypson ML. Beyond cultural competence: critical consciousness, social justice, and multicultural education. Academic Medicine. 2009; 84(6):782-7.

Clancy C. Improving care quality and reducing disparities: physicians' roles. Archives of Internal Medicine. 2008; 9;168(11):1135-6.

Ko, M., Heslin, K.C., Edelstein, R.A. & Grumbach, K. The role of medical education in reducing health care disparities: The first ten years of the UCLA/drew medical education program. Journal of General Internal Medicine, 2007; 22(5): 625-631.

Smedley, B.D., Stith, A.Y., & Nelson, A.R. Unequal treatment: Confronting racial and ethnic disparities in health care. 2002; Institute of Medicine Report. Washington, D.C.: National Academy Press.

More reading materials will be distributed in class for specific case studies.

Additional Readings: Daniels, Norman, Bruce Kennedy, and Ichiro Kawachi, eds . (2000) Is Inequality Bad for our Health? Boston: Beacon Press.

Grodin, Michael A., Daniel Tarantola, George J. Annas, and Sofia Gruskin, eds . (2013) Health and Human Rights in a Changing World. New York: Routledge.

59 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: History of Medicine Number of course: 481-8-2050

BGU Credits: 1 Course Description: Through case studies, this course analyzes the failures and successes that th th ECTS credits: constitute landmarks in the 19 -20 centuries of the history of medicine. Exploring science and practice, the laboratory and the field, we will bring a critical focus to questions of contexts, changes and continuities over time. Academic year: 2019-20

Learning outcomes of the course: Semester: 1 On successful completion of the course, the student should be able to:

Hours of instruction: 13 1. Relate the history of infectious diseases to their socio-cultural-economic contexts 2. Understand the complexity of the relationship between laboratory Location of instruction: science and field medical practice. Faculty of Health Sciences classroom 3. Understand the political, social, and economic institutions and practices that influence the history of medicine and infectious disease. 4. Appraise the selection and appreciate the diversity of health systems Language of instruction: English according to changing populations and needs.

Cycle: Ist Attendance regulation: Mandatory

Position: Elective module Teaching arrangement and method of instruction: Frontal lectures (including film and video materials), class and small group discussions and student presentations Field of Education: MD

Responsible department: MSIH Assessment: Attendance and participation

General prerequisites: NA

Work and assignments: Grading scale: Pass/Fail 1. Read assigned material 2. Write and submit responses to readings as preparation for class and group discussions.

3. Attend lectures

60 Ben-Gurion University of the Negev Medical School for International Health

Course Content; schedule and outlines: Lecturer: Dr. Maureen Malowany Please note there will be three classes. Each class will include readings and a Contact details presentation on a selected case study relative to the topic. Readings to be assigned. Office phone: 02-677108; Mob: 052 -2438709 Session 1: From Hippocrates to Ronald Ross: Introduction to the History of Infectious Diseases within the History of Medicine. 2. History of Malaria control, eradication, elimination - including the work of Israel Kligler during the Mandate

Email: [email protected] period. Malaria allows an investigation/exploration of early laboratory science (Ronald Ross, e.g.) and field trials - mosquito control (Robert Koch and early quininization, Alphonse Laveran, Rockefeller Foundation scientists, etc.), exploring

Office hours: Before/After class on successes and failures. 3. Bubonic Plague and contemporary cholera: transmission

Wednesdays. without a mosquito. Case studies: Cholera outbreaks both indigenous (Democratic Republic of Congo) and ‘imported’ (Haiti).

Course evaluation: Session 2: History of Human Experimentation - from James Lind through eugenics Debriefing at completion of all and Nazi experiments to contemporary clinical trials. Explores issues of changes in modules. medical technology, ethics, relationships between those conducting trials and trial subjects/participants. Case studies: Vaccine trials (cerebo-spinal meningitis Confirmation: 2019-20 (Nigeria), Ebola (West Africa)

Session 3: History of Health Service Organization and Delivery: mobile medicine Last update: Sept. 2019 from the Belgian Congo in the 1930s to community health in the 1960s including the ‘invention’ of community health workers. Contemporary organizational frameworks: HMOs/health funds (Israel), public-private partnerships (international agencies and stakeholders) and the challenges of addressing health delivery in under-resourced settings. Case studies: Dr .Dixon Chibanda, ‘Why I train grandmothers to treat depression’,TEDWomen 2017; Titaley et al. (2010)“Why do some women still prefer traditional birth attendants and home delivery?: a qualitative study on delivery care services in West Java Province, Indonesia”, BMC Pregnancy and Childbirth 10:43.

Required reading: * Session 1: Timothy C. Winegard, The Mosquito. A Human History of Our Deadliest Predator; Chapter 7: The Columbian Exchange: Mosquitoes and the Global Village. Allen Lane/Penguin Random House: Canada, 2019, 142-64. M.J. Dobson, M. Malowany, R.W. Snow (2000) “Malaria control in East Africa: the Kampala Conference and the Pare-Taveta Scheme: a meeting of common and high ground”, Parassitologia 42: 149-166. Martin Enserink. “Eradication goal splits malaria community”, Science 365 (6456), 847-848. DOI: 10.1126/science.365.6456.847 Brian Greenwood (2009) Can Malaria Be Eliminated? Transactions of the Royal Society of Tropical Medicine and Hygiene, 103S, S2—S5. Mark Harrison (2006). Disease, diplomacy and international commerce. The origins of international sanitary regulation in the nineteenth century. Journal of Global History, 1(2), 197-217. Doi:10.1017/S1740022806000131

Session 2: Allan M. Brandt.(1978) Racism and Research: The Case of the Tuskegee Syphilis Study, The Hastings Center Report, Vol. 8, No. 6, pp. 21-29. David M. Kent, et al.,Clinical Trials in Sub-Saharan Africa and Established Standards of Care (2004) JAMA, Vol 292, No. 2, 237-42. A A Hyder, S A Wali, A N Khan, et al. (2004) Ethical review of health research: a perspective from developing country researchers, J Med Ethics 30: 68-72.

Session 3: Francois-Xavier Mbopi-Keou, et al. (2014) The Legacies of Eugéne Jamot and La Jamotique , PLOS Neglected Tropical Disease, Vol. 8, Issue 4, e3635. . Marcus Cueto,(2004) The origins of Primary Health Care and Selective Primary Health Care, AJPH, Vol. 94, No. 11, 1864-1874. 61 Mark Clarfield, et al.2 (2017) Health and health care in Israel: an introduction, The Lancet 389: 10088, 2503-2513 ISSN 0140-6736 https://doi.org/10.1016/S0140-6736(17)30636-0. Name of the course: Medical Innovation: Digital Health and Devices Number of course:

BGU Credits: 1 Course Description: The module introduces students to the processes involved in Number of course: conceptualizing, assessing, researching, designing, and presenting ideas for ECTS credits: devices for low-income medical settings.

Academic year: Aims of the course: To expose students to the world of entrepreneurship, engineering, design, production and finance of medical devices. Semester: 1&2 Objectives of the Course: To recognize the processes involved in conceptualizing and creating a medical Hours of instruction: 12 device or application, conducting required research, assessing available resources, prototyping, and presenting idea to potential investors. Location of instruction: Faculty of Health Sciences classrooms Learning outcomes of the course: On successful completion of the course, the Language of instruction: English student should be able to: 1. Identify a medical scenario in a low-income country for which a new Cycle: 1st technical solution may be designed. 2. Research the need for a device and the alternatives already available. Position: Elective module 3. Work with Biomedical Engineers to understand the process for assessing technical solutions, while providing them with relevant data. (E.g. limited Field of Education: MD resources available in low-income settings). 4. Understand the barriers and obstacles to the development of such Responsible department: MSIH devices. 5. Make a presentation of an idea to potential investors. General prerequisites: None Attendance regulation: Grading scale: Mandatory Pass/Fail Teaching arrangement and method of instruction: Students required to bring three ideas for discussion at first session. During four class sessions, they will be taught the principles of the development process, design, and how to take their idea further.

62 Lecturers: Assessment: Course Coordinators: Bringing ideas at first meeting, attendance, last session presentation Dr. Yair Sadaka Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: Contact details:

Yair Sadaka [email protected] Research existing medical devices, formulate the idea, and build a basic business model Office hours: Module Content\ schedule and outlines: Lesson 1 Course evaluation: Introduction to medical startups. Online student survey and debriefing at the end Class split into groups. Brainstorm about ideas brought to class. Confirmation: One hour working on project. The syllabus was confirmed by the faculty academic advisory 30 minutes presenting. committee to be valid 2019-20 Lesson 2 Last update: Sept. 2019 45 minutes studying how to search for existing solutions on the market 45 minutes - From Idea to a Product One hour working with students of Biomedical Engineering (Matan & Roni) explaining prototyping process 30 minute student presentation

Lesson 3 Basics of business model How to create a presentation for investors. Success stories. Create presentation and present to course coordinators

Lesson 4 Final presentation competition

Required reading: Textbook

Additional literature:

* All learning material will be available to the students on the module's website (Moodle)/ library/ electronic documents available to BGU students.

63 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Medicine and Literature Number of course: 481-8-2015

BGU Credits: 1 Course Description:

Aims of the course: ECTS credits: Introducing Medical Humanities; making the students aware of the role of language and communication in medicine; demonstrating and discussing the non- Academic year: 2019-20 transparency, ambiguity and indeterminacy of language, openness of interpretation, and how all these come into play in both literature and medicine. Emphasizing the importance of reflective writing for the professional and Semester: Spring personal growth of a medical student; discussing cross-cultural communication issues in international medicine. Hours of instruction: 12 Objectives of the course: reading of literature and critical/theoretical works on the syllabus, active participation in class discussions, submitting a creative writing Location of instruction: piece.

Learning outcomes of the course: Language of instruction: English On successful completion of the course, the student should be able to: 1. Appreciate the function of language and narrative analysis in medical Cycle: MD practice. 2. Be aware of reading and writing literature as a way to access widely different and otherwise “invisible” perspectives, in particular those of Position: patients. 3. Become more tolerant and resilient towards the inevitable ambiguity Field of Education: Medicine that interpreting words, signs and symptoms involves.

Attendance regulation: Attendance is mandatory Responsible department: MSIH

Teaching arrangement and method of instruction: General prerequisites: None Session 1: Introduction: What does literature have to do with medicine? Narrative and Poetry: William Carlos Williams, “The Use of Force,” selected Grading scale: Pass/Fail poems; essay: Gerda Elata-Alster, “Poetry in the Medical Classroom.” Reflection on literary and medical interpretive practices. Session taught by Dr. Olga Kuminova

Session 2: Graphic Medicine and Poetry: Sarah Levitt, “Tangles”; Elizabeth Bishop, “One Art.” Session taught by Liza Futerman.

Session 3 Novel: Selection from Indra Sinha, Animal’s People. Session taught by Dr. Olga Kuminova.

Session 4: Reading and discussion of the students’ creative writing.

64

Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Olga Kuminova Assessment: Any student who has attended all the classes and submitted the Contact details creative writing piece passes the course. Office phone: Work and assignments: Reading the class materials before each class. 052-4439877 Email: Time required for individual work: [email protected] In addition to attendance in class, the students are expected to write a short piece Office hours: of creative writing in any genre but no longer than 1500 words (approximately).

Course evaluation: Debriefing at completion of all module.

Confirmation: Oct. 2019

Last update: 2019-20

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 65 2 Name of the course: Medicine and Society Number of course: 481-8-9050

BGU Credits: 1 Course Description: The relationship between medicine and society is a cornerstone of our understanding of health and disease. From the macro-level questions ECTS credits: surrounding patterns of inequality and globalization processes, to the most micro-level individual questions of illness experiences and meaning, the social sciences have engaged in exploring and theorizing the relationship between Academic year: medicine and society. 2017-18 Objectives of the course: The course will introduce students to various aspects of the relationship Semester: 1st semester between medicine and society, as they are understood from the perspective of the social sciences. During the course we will explore how cultures and societies structure and address health, illness and the mechanisms surrounding Hours of instruction: 12 them. hours Learning outcomes of the course: On successful completion of the course, the student should be able to: Location of instruction: Faculty of Health 1. Understand the relationship between medicine, society and culture Sciences classroom beyond the bio-medical perspective. 2. Understand the complexity of the relationship between medicine and Language of society. instruction: English 3. Recognize various theories explaining the relationship between medicine and society. 4. Understand health and illness in social and cultural contexts. Cycle: 1st

Attendance regulation: Position: Mandatory attendance. Elective module Teaching arrangement and method of instruction: Field of Education: MD Lectures and discussions

Responsible Assessment: department: MSIH 50% attendance and participation 50% case study presentation

General prerequisites: Work and assignments: 1. Students will read the assigned materials. Grading scale: Pass/Fail 2. Students will participate in class discussions.

66 Lecturer: Time required for individual work: Anat Rosenthal PhD Course Content\ schedule and outlines:

Contact details Meeting 1: Medicine, culture and society: theory, terminology and experience. Meeting 2: Poverty and health: was all medicine created equal? Meeting 3: Infectious relationships: infectious diseases and social histories. Office phone: Meeting 4: Case studies in medicine and society. 08-6477421 Required reading:

Email: * Kleinman, A. (1988). The Illness Narratives: Suffering, Healing and the Human [email protected] Condition. New- York: Basic Books. Pp.4-18.

* Taylor, J.S. (2003). "Confronting ‘‘Culture’’ in Medicine’s ‘‘Culture of No Office hours: Culture’’". Academic Medicine, 78(6):555-559.

By appointment * Specter, M. (2010) "A deadly diagnosis: Is it possible to save the millions of people who die from TB?" The New Yorker. November 15, 2010. Course evaluation: http://www.newyorker.com/magazine/2010/11/15/a-deadly- Debriefing at misdiagnosis?reload completion of all modules * Zaman, S. (2004). "Poverty and Violence, Frustration and Inventiveness: Hospital Ward Life in Bangladesh". Social Science and Medicine, 59(10):2025- 2036. Confirmation: 2019-20 * Farmer, P. (2003). Pathologies of Power: Health, Human Rights and the New War on the Poor. Berkeley: University of California Press. (Chapter 4). Last update: Sept. 2019 Additional literature:

*Ivry, T. (2009). “The Ultrasonic Picture Show and the Politics of Threatened Life” Medical Anthropology Quarterly, 23(3):189-211.

* Onuoha, F.C. (2009). "Why the Poor Pay with their Lives: Oil Pipeline Vandalisation, Fires and Human Security in Nigeria". Disasters, 33(3): 369−389.

* Singer, M (2009). "Why is it Easier to Get Drugs than Drug Treatment in the United States?" In Brown, P.J. and Barrett, R. Understanding and Applying Medical Anthropology. New York: McGraw-Hill. Pp. 93-100.

* Rosenberg, C.E. (1989). “What is an Epidemic? AIDS in Historical Perspective”. Daedalus, 118(2):1-17.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

67 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Migration and health: cross-cultural perspectives Number of course: 481-8-9060

BGU Credits: 1 Course Description: The scale of migration in the globalized world has made migrant health one of the top priorities of public health. This issue is exacerbated by the diversity of migrant populations, their motives ECTS credits: for migrating and the contexts of their migration, ranging from students and people searching for work to more vulnerable groups such as refugees and asylum seekers. The migration process Academic year: 2019-20 can deeply affect people’s lifestyles, their health and healthcare. Thus, this course will explore the complex relationships between migration and health in the international context using an Semester: second anthropological perspective. This will allow us to enhance the understanding of the needs and socio-cultural barriers faced by migrants, as well as the challenges facing health providers and Hours of instruction: policy makers. 12 Aim of the course: Location of instruction: To provide the students with insights on key health issues affecting migrant populations and the myriad of socio-cultural factors that influence them TBA Language of instruction: Objectives of the course 1. To introduce students to fundamental concepts, methods, and debates in the analysis English of migration health from an anthropological perspective 2. To contextualize these debates within the various opportunities and challenges of inter- Cycle: 1st disciplinary research and health care for migrant populations

Learning outcomes of the course: Position: Elective module On successful completion of the course, the students should: 1. Increase their understanding of the myriad of factors affecting the health of migrants and refugees Field of Education: MD 2. Enhance their culture and gender sensitivity to issues related to migrant health and medical care Responsible department: 3. Promote inter-student discourse about practical, ethical and other issues arising from MSIH the learning process

Attendance regulation: Mandatory. General prerequisites: Teaching arrangement and method of instruction: 1. Lectures and interactive methods (discussions of articles and short video-clips) Grading scale: 2. Group work Pass/Fail 3. Student presentations and discussions Assessment: 50% Assistance and participation in class 50% Presentations on health issues among migrants

Work and assignments: The class will work in small groups, focusing on the different health issues among migrants. Each group will prepare a presentation, including a discussion on a specific topic.

Time required for individual work: In addition to attendance in class, the students are expected to work on readings and assignments for 4 hours between classes.

68 1 Ben-Gurion University of the Negev Medical School for International Health

Course Content: Lecturer: 1. Migration and health: an overview Dr. Anita Nudelman 2. Anthropological perspective on health issues among migrants. Social determinants of the health of migrants 3. Migration policy and access to health care systems. The migrant crisis in Europe Contact details: 4. Medical pluralism: use of modern and traditional healing among migrants. Culture competency in health services for migrants 5. Global health issues among migrant populations, including infectious Office phone: diseases (in developed and developing countries) 6. Women’s reproductive health and gender perspectives in migration Email: [email protected]; 7. Migration and mental health [email protected] Readings: Anarfi, J, Quartey, P & Ageyei, J. (2010). Key Determinants of Migration among Health Office hours: Professionals in Ghana. Development Research Centre on Migration, Globalisation and Poverty. University of Ghana

Course evaluation: European Parliament (2016). The public health dimension of the European migrant Debriefing at completion course crisis.http://www.europarl.europa.eu/RegData/etudes/BRIE/2016/573908/EPRS_BRI(2016) 573908_EN.pdf

Confirmation: Oct. 2019 Gele. A.A., Kumar,B., Harsløf Hjelde, K. & Sundby, J. (2012). Attitudes toward female circumcision among Somali immigrants in Oslo: a qualitative study. International Journal of Women’s Health 4, 7–17, Last update: 2019-20 Hardley C. Editor (2010). NAPA Bulletin 34: Anthropological Perspectives on Migration and Health (selected chapters).

IOM Nairobi (2010). An analysis of Migration health in Kenya http://publications.iom.int/bookstore/free/An%20Analysis%20of%20Migration%20Health% 20in%20Kenya.pdf

Quosh C, Eloul L & Ajlani R. (2013). Mental health of refugees and displaced persons in Syria and surrounding countries: a systematic review. Intervention 11(3), 276 – 294

Rechel B, Mladovsky P, Deville W, Rijks B, Petrova-Benedict R and Mckee M. Editors (2011). Migration and health in the European Union. Open University Press (selected chapters)

Siriwardhana, C. and Stewart, E. (2013). Forced migration and mental health: prolonged internal displacement, return migration and resilience. International Health 5 (1): 19-23 http://inthealth.oxfordjournals.org/content/5/1/19.full.pdf+html

WHO (2010). Health of Migrants – The Way Forward: Report of Global Consultation http://www.who.int/hac/events/consultation_report_health_migrants_colour_web.pdf

Xu, S., Cheng, J., Zhan, S. & Blas E. (2011). Dedicated delivery centre for migrants in Minhang District, Shanghai. In: Blas, E., Sommerfeld, J., Sivasankara Kurup, A . Social Determinants Approaches to Public Health: from Concept to Practice. Geneva: WHO, 50-62

Zimmerman C, Kiss L, Hossain M (2011). Migration and Health: A Framework for 21st Century Policy-Making. PLoS Med 8(5): e1001034. doi:10.1371/journal.pmed.1001034 http://www.ploscollections.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001034;js essionid=4FC4E1D0A4D140D59FB21F3E1E45593A

69 2 Ben- Gurion University of the Negev Medical School for International Health

Name of the module: Introduction to Mindfulness as a method for self-care and wellbeing Module Number:

BGU Credits: 1 Course Description: Mindfulness is the ability to witness what is happening here ECTS credits: and now with nonjudgmental attention to mind, emotions, thoughts, impulses and bodily sensations. This ability enables us to reduce automatic Academic year: 2019-2020 responsiveness, and develop an accepting and compassionate attitude. Semester: 2 Mindfulness has been shown to assist in coping with pain, depression, stress, and Hours of instruction: 12 burnout feelings that may be expressed as compassion fatigue among health care teams. Location of instruction: The students will learn: what is Mindfulness, its relation to health outcomes, how The Faculty of Health Sciences to nurture it and use it for self-care and promoting wellbeing.

To be considered Language of instruction: English Class exercises as well as in home exercises, are devoted to focusing on thoughts, feelings and physical sensations, which can sometimes cause discomfort, Cycle: 1st especially among people with special sensitivities or history of emotional or mental disorders. Therefore, it is recommended that each student will consider whether the course is suitable for him or her at this stage in life. Position: Elective module Responsible department: Aims of the module: department/MSIH 1. To enable students to familiarize themselves with Mindfulness and its relevance to personal and professional life. 2. To enable students to cultivate Mindfulness for self-care and increase Grading scale: Pass/Fail compassion for the self and others.

Objectives of the module: Lectureres: At the end of this module students will be able to; Miriyam Farksh, 1. Describe what Mindfulness is and how it promotes well-being. Itay Pruginin 2. Describe formal and informal ways to cultivate Mindfulness. 3. Demonstrate the ability to use Mindfulness techniques.

Contact details: Teaching arrangement and method of instruction: Office phone: 77659 Mixed teaching methods will be used, such as large group and small group Email: [email protected], discussions Students will be taught various mindfulness practices through direct experience [email protected] with mindfulness meditation. Office hours: appointment with the lecturer Course discussions will be conducted while maintaining confidentiality rules. Any violation of confidentiality will constitute a serious breach of academic and Course evaluation: professional ethics. Online student survey and debriefing at the end Assessment: 2. Submission of a diary describing the home practice. Confirmation: 2019-20 3. Submission of a final paper.

Work and assignments: Last update: Sept. 2019 1. Presence and active participation in classroom exercises. 2. Submission of a diary describing the practice at home. 3. Term Paper.

70 Ben- Gurion University of the Negev Medical School for International Health

4. Time required for individual work: in addition to attendance in class, the students are expected to practice10 minutes a day and feel up a journal at the total of about 3 hours a week.

5. Module Content\ schedule and outlines:

Session Theme Mindfulness meditation practices and cognitive exercises No'1 Introduction to mindfulness Introduction to the Body Scan Formal and Informal Mindfulness Practice

No 2' Attention & The Brain Introduction to Sitting Meditation Responding vs. Reacting STOP: One-Minute Breathing Space No 3' Automatic pilot Mindfulness of eating Mindfulness and Compassion Lovingkindness Meditation No 4' Thoughts are Two arrows: Pain vs. suffering. not facts Using what has Dealing with difficulty within been learn. a meditation

Review of course content.

71 Ben- Gurion University of the Negev Medical School for International Health

Required reading:

First Session : 1. Greeson, J. M. (2009). Mindfulness research update: 2008. Complementary health practice review, 14(1), 10-18. 2. Petitmengin, C., Van Beek, M., Bitbol, M., & Nissou, J. M. (2017). What is it Like to Meditate?: Methods and Issues for a Micro-phenomenological Description of Meditative Experience. Journal of Consciousness Studies, 24(5-6), 170- 198. 3. Kabat-Zinn, J. (2011). Some reflections on the origins of MBSR, skillful means, and the trouble with maps. Contemporary Buddhism, 12(01), 281-306.

Second Session: 1.Foster, J. (2011). Therapy Without a Therapist: Nonduality, Healing and the Search for Wholeness. Retrieved from: https://undividedjournal.com/2011/09/30/therapy-without-a-therapist-nonduality-healing-and-the-search-for-wholeness/ 2. Young, S. (2006). What is mindfulness. Retrieved on Shinzen. org. 3. Bayda, E. (2004). At home in the muddy water: A guide to finding peace within everyday chaos. Shambhala Publications. (Chapter 6 – Attachment)

Third Session: 1. Kurtz, R. (1990). Body-centered psychotherapy: The Hakomi method: The integrated use of mindfulness, nonviolence, and the body. LifeRhythm. (introduction) 2. Safran, J. D. (Ed.). (2003). Psychoanalysis and Buddhism: An unfolding dialogue. Simon and Schuster. (Chapter 6 – Your Ordinary Mind) 3. Van Gordon, W., & Shonin, E. (2018). Mindfulness: The art of being human. Mindfulness, 9(2), 664-666.

Fourth Session: 1. Welwood, J. (Ed.). (1992). Ordinary magic: Everyday life as spiritual path. Shambhala. (Sunshine and Green Leaves) 2. Chödrön, P. (2008). Comfortable with uncertainty: 108 teachings on cultivating fearlessness and compassion. Shambhala Publications. (The Love that Will Not Die) 3. Brazier, C. (2012). Buddhist psychology. Robinson. (Chapter 9)

Additional literature; will be provided during the course.

72 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Neglected tropical diseases Number of course: 481-8-2082

BGU Credits: 1 Course Description: ECTS credits: Attendance regulation: Mandatory Academic year: 2019-20 Semester: 2 Module Content\ schedule and outlines: Hours of instruction: 12 1. HIV immunopathogenesis and co-infection -TH1/TH2 immune profile Location of instruction: -Chronic immune activation -Immunology of HIV and co-infections Faculty of Health Sciences classrooms 2. NTDs and Global Health Language of instruction: English -How tropical diseases became “neglected” -What is meant by Neglected Tropical Diseases (NTDs) Cycle: 1st -Current Epidemiology surrounding NTDs 3. NTD pathogenesis: Ascariasis, Trichuriasis, Hookworm Position: Elective module 4. NTD pathogenesis: Schistosomiasis Field of Education: MD 5. NTD pathogenesis: Filariasis Responsible department: MSIH General prerequisites: None 6. NTD pathogenesis: Leishmaniasis Grading scale: Pass/Fail 7. NTD co-infection and Malaria

Lecturers: 8. NTD co-infection and TB Prof. Zvi Bentwich 9) NTD (helminth) and HIV co-Infection Course Coordinators: Prof. Zvi Bentwich 10) Helminth treatment and eradication with co-infections in the developing world -Childhood deworming programs Contact details: -Health impacts (individuals, community) Office phone: Email: [email protected] Assessment: Course evaluation: Attendance and participation Online student survey and debriefing at the end

Confirmation: The syllabus was confirmed by the faculty academic advisory committee to be valid on 2019-20

Last update: Sept. 2019

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Literature : 1. HIV immunopathogenesis and co-infection A) Douek D. HIV disease progression: immune activation, microbes, and a leaky gut. Top HIV Med 2007; 15:114–117.

B) Bentwich Z, Kalinkovich A, Weisman Z (1995) Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today 16: 187–191.

C) Kassu A, Tsegaye A, Wolday D, Petros B, Aklilu M, et al. (2003) Role of incidental and/or cured intestinal parasitic infections on profile of CD4+ and CD8+ T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians. Clin Exp Immunol 132: 113–119.

D) Borkow G, Bentwich Z (2004) Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and alergy. Clin Microbiol Rev 17: 1012–30, table.

E) Cox, F. E. G. (2001). Concomitant infections, parasites and immune responses. Parasitology, 122 (Suppl.), S23–S38.

F) Hazenberg MD, Otto SA, van Benthem BH, et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003; 17:1881–8.

G) Catalfamo M, Di Mascio M, Hu Z, Srinivasula S, Thaker V, Adelsberger J, Rupert A, Baseler M, Tagaya Y, Roby G, Rehm C, Follmann D, Lane HC. HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19851-6.

H) Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, Dong T, Chesney G, Waters A, Easterbrook P, Dunbar PR, Shepherd D, Cerundolo V, Emery V, Griffith P, Conlon C, McMichael AJ, Richman DD, Rowland-Jones SL, Appay V. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1infection. PLoS Biol. 2004 Feb;2(2):E20. \

I) Padmini Salgame, George S yap and William C Gause. Effect of helminth-induced immunity on infections with microbial pathogens. Nature Immunology, Nov 2013; 14(11): 1118-1126

J) Emily L. Webb, Andrew O. Ekii and Pietro Pala. Epidemiology and Immunology of helminth – HIV interactions. Curr Opin HIV AIDS, 2012; 7:245-253

2. NTDs and Global Health A) Hotez PJ, Mistry N, Rubinstein J, Sachs JD. Integrating neglected tropical diseases into AIDS, tuberculosis, and malaria control. N Engl J Med. 2011 Jun 2;364(22):2086-9.

B) Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, et al. (2007) Control of neglected tropical diseases. N Engl J Med 357: 1018–1027.

C) Karp CL, Auwaerter PG (2007) Coinfection with HIV and tropical infectious diseases. II. Helminthic, fungal, bacterial, and viral pathogens. Clin Infect Dis 45: 1214–1220.

D) Lancet Editorial (November 4, 2006) US AIDS coordinator shuns collaboration on Neglected Disease. The Lancet 368: 1547.

E) Smits HL. Prospects for the control of neglected tropical diseases by mass drug administration. Expert Rev Anti Infect Ther. 2009 Feb;7(1):37-56.

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Additional literature: F) G. G. Simon. Impacts of neglected tropical disease on incidence and progression of HIV/AIDS, tuberculosis, and malaria: scientific links. International Journal of infectious Diseases, 2016; 42: 54-57

G) Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs SE, et al. (2006) Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med 3(5): e102.

H) Noblick J, Skolnik R, Hotez PJ (2011) Linking Global HIV/AIDS Treatments with National Programs for the Control and Elimination of the Neglected Tropical Diseases. PLoS Negl Trop Dis 5(7): e1022. doi:10.1371/ journal.pntd.0001022

I) Hotez PJ, Molyneux DH (2008) Tropical Anemia: One of Africa’s Great Killers and a Rationale for Linking Malaria and Neglected Tropical Disease Control to Achieve a Common Goal. PLoS Negl Trop Dis 2(7): e270. doi:10.1371/journal.pntd.0000270

3. NTD pathogenesis: Ascariasis, Trichuriasis, Hookworm A) Control of neglected tropical diseases needs a long-term commitment. Zhang Y, MacArthur C, Mubila L, Baker S. BMC Med. 2010 Oct 29;8:67. Review.

B) Walson JL, John-Stewart G (2007) Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. PLoS Negl Trop Dis 1: e102. doi:10.1371/journal.pntd.0000102.

C) Brooker, S., Clements, A. C. A. & Bundy, D. A. (2006). Global epidemiology, ecology and control of soil-transmitted helminth infections. Advances in Parasitology, 63, 223–265

D) Cooper, P. J., Chico, M. E., Sandoval, C., Espinel, I., Guevara, A., Kennedy, M. W., Urban Jr, J. F., Griffin, G. E. & Nutman, T. B. (2000). Human infection with Ascaris lumbricoides is associated with a polarized cytokine response. Journal of Infectious Diseases, 182, 1207–1213.

E) Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J/. Helminth infections: the great neglected tropical diseases.J Clin Invest. 2008 Apr;118(4):1311-21.

F) van Riet E, Hartgers FC, Yazdanbakhsh M. Chronic helminth infections induce immunomodulation: consequences and mechanisms. Immunobiology. 2007;212(6):475-90. Epub 2007 Apr 20.

4. NTD pathogenesis: Schistosomiasis

A) Diagnosis and management of schistosomiasis. Gray DJ, Ross AG, Li YS, McManus DP. BMJ. 2011 May 17;342:d2651. doi: 10.1136/bmj.d2651. Review.

B) Kjetland EF, Ndhlovu PD, Gomo E, Mduluza T, Midzi N, et al. (2006) Association between genital schistosomiasis and HIV in rural Zimbabwean women. AIDS 20: 593–600.

C) McElroy MD, Elrefaei M, Jones N, Ssali F, Mugyenyi P, et al. (2005)Coinfection with Schistosoma mansoni is associated with decreased HIV-specific cytolysis and increased IL-10 production. J Immunol 174: 5119–5123.

D) Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. Schistosomiasis and water resources development: sytematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis 2006;6:411-25.

E) Engels D, Savioli L. Public health strategies for schistosomiasis control. In: Secor WE, Colley DG, eds. World class parasites: Vol. X, schistosomiasis. New York: Springer, 2005:207-22.

75 3 Ben-Gurion University of the Negev Medical School for International Health

F) Bergquist NR, Leonardo LR, Mitchell GF. Vaccine-linked chemotherapy: can schistosomiasis control benefit from an integrated approach? Trends Parasitol 2005; 21:112-7.

G) Secor WE. Interactions between schistosomiasis and infection with HIV-1. Parasite Immunol 2006; 28:597–603.

H) Kallestrup P, Zinyama R, Gomo E, Butterworth AE, van Dam GJ, Gerstoft J, Erikstrup C, Ullum H. Schistosomiasis and HIV in rural Zimbabwe: efficacy of treatment of schistosomiasis in individuals with HIV coinfection. Clin Infect Dis. 2006 Jun 15;42(12):1781-9. Epub 2006 May 10.

5. NTD pathogenesis: Filariasis

A) Hoerauf A, Pfarr K, Mand S, Debrah AY, Specht S. Filariasis in Africa--treatment challenges and prospects. Clin Microbiol Infect. 2011 Jul;17(7):977-85. doi: 10.1111/j.1469-0691.2011.03586.x. Review.

B) Nielsen NO, Simonsen PE, Dalgaard P, Krarup H, Magnussen P, et al. (2007) Effect of diethylcarbamazine on HIV load, CD4%, and CD4/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial. Am J Trop Med Hyg 77: 507–513.

C) Ottesen EA. Lymphatic filariasis: treatment, control and elimination. Adv Parasitol 2006;61:395-441

D) Nielsen NO, Simonsen PE, Magnussen P, Magesa S, Friis H. Cross-sectional relationship between HIV, lymphatic filariasis and other parasitic infections in adults in coastal northeastern Tanzania. Trans R Soc Trop Med Hyg. 2006 Jun;100(6):543- 50.

E) Weil GJ, Ramzy RMR. Diagnostic tools for filariasis elimination programs. Trends Parasitol 2007;23:78-82.

F) Dietze KK, Dittmer U, Koudaimi DK, Schimmer S, Reitz M, Breloer M, et al. (2016) Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads. PLoS Negl Trop Dis 10(12): e0005170. doi:10.1371/ journal.pntd.0005170

6. NTD pathogenesis: Leishmaniasis

A) Tiuman TS, Santos AO, Ueda-Nakamura T, Filho BP, Nakamura CV. Recent advances in leishmaniasis treatment.Int J Infect Dis. 2011 Aug;15(8):e525-32. Epub 2011 May 24. B) Desjeux P. The increase in risk factors for leishmaniasis worldwide. Trans R Soc Trop Med Hyg 2001;95:239-43.

C) Coler RN, Reed SG. Second-generation vaccines against leishmaniasis. Trends Parasitol 2005;21:244-9.

D) Pintado V, Martin-Rabadan P, Rivera ML, Moreno S, Bouza E. Visceral leishmaniasis in human immunodeficiency virus (HIV)–infected and non–HIV-infected patients: a comparative study. Medicine (Baltimore) 2001; 80:54–73.

E) Ritmeijer K, Dejenie A, Assefa Y, et al. A comparison of miltefosine and sodium stibogluconate for treatment of visceral leishmaniasis in an Ethiopian population with high prevalence of HIV infection. Clin Infect Dis 2006; 43:357–64.

F) Monge-Maillo B, Norman FF, Cruz I, Alvar J, Lo´pez-Ve´lez R (2014) Visceral Leishmaniasis and HIV Coinfection in the Mediterranean Region. PLoS Negl Trop Dis 8(8): e3021. doi:10.1371/journal.pntd.0003021

G) Diro E, Lynen L, Ritmeijer K, Boelaert M, Hailu A, et al. (2014) Visceral Leishmaniasis and HIV Coinfection in East Africa. PLOS Negl Trop Dis 8(6): e2869. doi:10.1371/journal.pntd.0002869

76 4 Ben-Gurion University of the Negev Medical School for International Health

7. NTD co-infection and Malaria

A) Kirwan P, Jackson AL, Asaolu SO, et al. Impact of repeated four-monthly anthelminthic treatment on Plasmodium infection in preschool children: a double-blind placebocontrolled randomized trial. BMC Infect Dis 2010;10:277

B) Gallagher M, Malhotra I, Mungai PL, Wamachi AN, Kioko JM, et al. (2005) The effects of maternal helminth and malaria infections on mother-to-child HIV 45: 1214–1220.

C) Mwangi, Bethony and Brooker (2006) Malaria and helminth interactions in humans: an epidemiological viewpoint. Annals of Tropical edicine and Parasitology 100 (7)” 551-570.

D) Briand, V., Watier, L., le Hesran, J. Y., Garcia, A. & Cot, M. (2005). Coinfection with Plasmodium falciparum and Schistosoma haematobium: protective effect of schistosomiasis on malaria in Senegalese children? American Journal of Tropical Medicine and Hygiene, 72, 702–707.

E) Diallo, T. O., Remoue, F., Schacht, A. M., Charrier, N., Dompnier, J. P., Pillet, S., Garraud, O., N’Diaye, A. A., Capron, A., Capron, M. & Riveau, G. (2004). Schistosomiasis co-infection in humans influences inflammatory markers in uncomplicated Plasmodium falciparum malaria. Parasite Immunology, 26, 365– 369.

F) Druilhe, P., Tall, A. & Sokhna, C. (2005). Worms can worsen malaria: towards a new means to roll back malaria? Trends in Parasitology, 21, 359–362.

8. NTD co-infection and TB

A) The impact of mucosal infections on acquisition and progression of tuberculosis. Perry S, Hussain R, Parsonnet J. Mucosal Immunol. 2011 May;4(3):246-51. Epub 2011 Mar 16. Review.

B) Kassu A, Mengistu G, Ayele B, Diro E, Mekonnen F, Ketema D, Moges F, Mesfin T, Getachew A, Ergicho B, Elias D, Wondmikun Y, Aseffa A, Ota F., HIV and intestinal parasites in adult TB patients in a in Northwest Ethiopia: Trop Doct. 2007 Oct;37(4):222-4.

C) Resende Co T, Hirsch CS, Toossi Z, Dietze R, Ribeiro-Rodrigues R. Intestinal helminth co-infection has a negative impact on both anti-Mycobacterium tuberculosis immunity and clinical response to tuberculosis therapy: Clin Exp Immunol. 2007 Jan;147(1):45-52.

D) Brown M, Miiro G, Nkurunziza P, Watera C, Quigley MA, Dunne DW, Whitworth JA, Elliott AM., Schistosoma mansoni, nematode infections, and progression to active tuberculosis among HIV-1-infected Ugandans: Am J Trop Med Hyg. 2006 May;74(5):819-25.

E) Hatherill M, Adams V, Hughes J, De Kock M, Mavakla W, Pienaar B, Mahomed H, Hussey G, Hanekom WA. The potential impact of helminth infection on trials of novel tuberculosis vaccines.Vaccine. 2009 Jul 30;27(35):4743-4. Epub 2009 May 29.

F) Subash Babu and Thomas B. Nutman. Helminth-Tuberculosis Co-infection: An Immunologic Perspective. Trends in Immunology, Sept 2016; 37 (9): 597-607

9) NTD (helminth) and HIV co-Infection

A) Modjarrad, K. and S.H. Vermund, Effect of treating co-infections on HIV-1 viral load: a systematic review. Lancet Infect Dis, 2010. 10(7): p. 455-63.

B) Borkow G, Bentwich Z (2006) HIV and helminth co-infection: is deworming necessary? Parasite Immunol 28: 605–612.

77 5 Ben-Gurion University of the Negev Medical School for International Health

C) Walson JL, John-Stewart G (2007) Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. PLoS Negl Trop Dis 1: e102. doi:10.1371/journal.pntd.0000102.

D) Borkow G, Teicher C, Bentwich Z (2007) Helminth–HIV Coinfection: Should We Deworm?. PLoS Neglected Tropical Diseases 1(3): e160 doi:10.1371/journal.pntd.0000160

E) Brown M, Kizza M, Watera C, et al. Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. J Infect Dis 2004; 190:1869–79.

F) Da'Dara AA, Lautsch N, Dudek T, Novitsky V, Lee TH, Essex M, Harn DA. Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice.Vaccine. 2006 Jun 12;24(24):5211-9. Epub 2006 Apr 18.

10) Helminth treatment and eradication with co-infections in the developing world -Childhood deworming programs -Health impacts (individuals, community)

A) Walson, J.L. and G. John-Stewart, Treatment of helminth co-infection in HIV-1 infected individuals in resource-limited settings. Cochrane Database Syst Rev, 2008(1): p. CD006419.

B) Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs SE, et al. (2006) Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med 3(5): e102.

C) Asaolu, S. O. & Ofoezie, I. E. (2003). The role of health education and sanitation in the control of helminth infections. Acta Tropica, 86, 283–294.

D) Remme JHF, Feenstra P, Lever PR, et al. Tropical diseases targeted for elimination: Chagas disease, lymphatic filariasis, onchocerciasis, and leprosy. In: Jamison DT, Breman JG, Measham AR, et al., eds. Disease control priorities in developing countries. 2nd ed. Oxford, England: Oxford University Press, 2006:433-50

E) Elliott AM, Kizza M, Quigley MA, Ndibazza J, Nampijja M, Muhangi L, Morison L, Namujju PB, Muwanga M, Kabatereine N, Whitworth JA. The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood. Clin Trials. 2007;4(1):42-57.

78 6 Second Year Systems and Global Health

79 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Anatomy - Abdomen and Pelvis Number of course: 481-8-2062

BGU Credits: Course Description: 4.5 Aims of the course ECTS credits: Human Anatomy is a systems-based course emphasizing medical-anatomical concepts and structural relationships in the body. Computer-assisted instruction Academic year: and advanced imaging/cross-sectional anatomy are employed together with 2019-20 frontal lectures and cadaver dissection to facilitate understanding and retention in the highly truncated time frame allotted to the course. Semester: 1st The use of senior medical students as teaching assistants in the dissection laboratory, an innovation developed at BGU, provides another critical component Hours of instruction: 70 to the course. These students bring their clinical experience and particularly their Lectures: 32 hours appreciation for anatomy as a key tool in the diagnosis and treatment of pathology to the dissection laboratory. Labs: 32 hours

Objectives of the course: Location of instruction: To provide students with a deep knowledge of abdominopelvic regional anatomy. Faculty of Health Sciences classrooms, Deichman Bldg. Learning outcomes of the course: On successful completion of the course, the student should be able to: Language of instruction: 1. Knowledge of structure and function of abdominopelvic organs, and English abdominopelvic topography Cycle: 2. The capability to implement this knowledge in understanding of abdominopelvic pathology 2nd Position: Attendance regulation: Mandatory system Lectures – mandatory Field of Education: Dissections – mandatory MD Responsible department: Teaching arrangement and method of instruction: MSIH Frontal lectures Tutorials in small groups General prerequisites: Dissection labs Successful completion of all prior courses

Grading scale: Honors/Pass/Fail

80 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Assessment: Dr. Dmitri Fishman Faculty written multiple choice test 50% Contact details: Lab component 50% Office phone : 100% 08-6477319, 08-6477314 Work and assignments: Attendance at lectures; attendance at dissections; self study at home and in Email: [email protected] dissection room

Office hours: Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: TBA at first lecture One day in the middle of the course is scheduled for self-study – 8 hours. One extra day is scheduled for self-study in the end of the course before the exam. Course evaluation: In addition, self-study in dissection room on evening hours is allowed and encouraged. Course debriefing after the exam

Module Content\ schedule and outlines: Confirmation: Abdomen and Pelvis The syllabus was confirmed by the 1. Anterior abdominal wall faculty academic advisory 2. Inguinal canal and hernia committee to be valid on November 3. Peritoneum 2019 4. The gut 5. Spleen, liver, Biliary System 6. Retroperitoneum Last update: 7. The pelvis 8. Pelvic organs September 2019 9. UG and perineum - male 10. Imaging of abdomen and pelvis 11. Embryology of abdomen and pelvis 12. UG and perineum - female 13. Clinical correlations

Required reading:  Grant's Atlas of Anatomy Or  Atlas of Human Anatomy, 4th Edition, Netter  Grant's Dissector  Clinically Oriented Anatomy, 4th or 5th Ed. Moore & Dalley, Lippincott Williams and Wilkins Or  Clinical Anatomy for Medical Students, Snell

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

81 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Anatomy – Chest and Thorax Number of course: 481-8-2063

BGU Credits: Course Description: 4.0 Aims of the course ECTS credits: Number of credits in the Human Anatomy is a systems-based course emphasizing medical-anatomical concepts and structural relationships in the body. Computer-assisted instruction European Credit Transfer System and advanced imaging/cross-sectional anatomy are employed together with Academic year: frontal lectures and cadaver dissection to facilitate understanding and retention in the highly truncated time frame allotted to the course. 2019-20 Semester: The use of senior medical students as teaching assistants in the dissection laboratory, an innovation developed at BGU, provides another critical component 1st to the course. These students bring their clinical experience and particularly their Hours of instruction: 56 appreciation for anatomy as a key tool in the diagnosis and treatment of pathology to the dissection laboratory. Lectures: 32 hours Labs: 24 hours Objectives of the course: Tutorials: NA To provide students with a deep knowledge of thorax anatomy.

Location of instruction: Learning outcomes of the course: On successful completion of the course, the student should have: Faculty of Health Sciences classrooms, Deichman Bldg. 1. Knowledge of structure and function of Thorax organs and topography 2. The ability to identify basic anatomical structures of the heart in echocardiographic (Echo) images Language of instruction: 3. The ability to identify basic anatomical structures of the chest in English computerized tomography (CT) images 4. The capability to implement this knowledge in understanding of Cycle: pathologies involving thoracic structures and organs 1st Position: Attendance regulation: Mandatory system Lectures – recommended Dissections – mandatory Field of Education: Echo session – mandatory MD CT sessions– mandatory Responsible department: MSIH Teaching arrangement and method of instruction: General prerequisites: Frontal lectures Dissection labs None Echo and CT labs Grading scale: Honors/Pass/Fail Assessment: Comprehensive Examinations: Written Component 50% Lab Component 50% Narrative Assessment

100%

82 Ben-Gurion University of the Negev Medical School for International Health

Coordinating Lecturer: Work and assignments: Prof. Yoram Etzion Attendance at lectures; attendance at dissections; self-study at home and in dissection room students are expected to do their assignment and individual work: Contact details : One day in the middle of the course is scheduled for self-study – 8 hours. Office phone: One extra day is scheduled for self-study in the end of the course before the exam. 08-6479987 In addition, self-study in dissection room on evening hours is allowed and encouraged.

Email: [email protected] Module Content\ schedule and outlines:

Office hours: Thorax anatomy 1. Anterior chest wall TBA at first lecture 2. The spinal nerve 3. Pleural cavity

Course evaluation: 4. Trilaminer disc (embryology) 5. Lungs (histology) Course debriefing after the exam 6. Development of lungs (embryology) 7. Pericardium & great vessels Confirmation: 8. Development of heart (embryology) 9. Mediastinum The syllabus was confirmed by the 10. Cardiac muscle (histology) faculty academic advisory 11. Heart committee to be valid on July 2019 12. Autonomic nervous system 13. Coronary circulation Last update: 14. Heart and aortic arches (embryology) July 2019-20 15. Surface anatomy 16. Fetal vs postnatal circulation 17. Chest Imaging: X-ray, Echo and CT

Required reading: If more than one, either is acceptable: Clinically Oriented Anatomy, Moore, K.L. (Williams and Wilkins) Clinical Anatomy for Medical Students, Snell, R.S. (Little Brown)

Atlas (one) Grants Atlas of Anatomy, Agur, A.M., (Williams and Wilkins) Regional Atlas of the Human Body, Clemente (Lea & Fibiger) Color Atlas of Anatomy, Rohan & Yokochi (Igaku-Shoin) Atlas of Human Anatomy, Netter, F. (Ciba-Geigy)

Dissector: Grants Dissector, Sauerland, E.K., 10th ed. (Williams and Wilkins)

Embryology Medical Embryology, Langman, J. 5th ed. (Lippincott, Williams and Wilkins)

Histology Histology: A Text and Atlas, Ross, Pawlina and Ross, 5th ed. (Lippincott, Williams and Wilkins)

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

83 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Anatomy - Head and Neck Number of course: 481-8-2064

BGU Credits: 5.2 Course Description: Aims of the course: ECTS credits: The Aim is to provide students with deep knowledge of topographic anatomy of the Head and Neck region in the body.

Academic year: 2019-20 Objectives of the course: The main objective is to emphasize medical-anatomical concepts and structural Semester: 2 relationships in the Head & Neck region. Frontal lectures and cadaver dissections are employed along with imaging/cross-sectional anatomy to facilitate understanding and retention in the highly truncated time frame allotted to the Hours of instruction: 77 course. The use of senior medical students as teaching assistants in the dissection laboratory, an innovation developed at BGU, provides another critical component Location of instruction: to the course. These students bring their clinical experience and particularly their Faculty of Health Sciences classroom appreciation for anatomy as a key tool in the diagnosis and treatment of pathology to the dissection laboratory. Language of instruction: English Learning outcomes of the course: On successful completion of the course, the student should be able: Cycle: 3rd 1. To be familiar with organization, spatial relations, blood supply, innervation and function of main structures in the Head and Neck region, Position: Mandatory system such as bones/joints, muscles and organs (ear, eye, etc.). 2. To demonstrate the capability of implementing this knowledge in understanding the Head and Neck pathology. Field of Education: MD

Attendance regulation: Responsible department: MSIH Lectures - mandatory Labs - mandatory General prerequisites: Successful completion of all prior courses Teaching arrangement and method of instruction: 1. Frontal lectures Grading scale: Honors/Pass/Fail 2. Dissection 3. Radiological anatomy demonstration lab

Assessment: Comprehensive examination faculty written: Practical examination in the dissection room – 50% Final written examination – 50%

84 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Work and assignments: Dr. D. Fishman Attendance to the lectures; attendance to dissections; self-study at home and in Contact details: dissection room Office phone : Time required for individual work: in addition to attendance in class, the students 08-6477319 , 08-6477314 are expected to do their assignment and individual work, as follows.

Email: One day in the middle of the course is scheduled for self-study – 8 hours One more day is scheduled for self-study in the end of the course before the exam. [email protected]; In addition, self-study in dissection room on evening hours is allowed and [email protected] encouraged.

Office hours: 12:00-13:00/twice Course Content\ schedule and outlines: Monday/Tuesday by appointment. Lectures: 1. The Skull Course evaluation: 2. The Neck and Neck triangles Online student survey and debriefing 3. Autonomic nervous system and cranial nerves at completion of course. 4. Cranial nerve II 5. Cranial nerve V 6. Meninges Confirmation: 2019-20 7. The eye 8. The ear 9. The nose, nasal cavity and paranasal sinuses Last update: 10. Oral civility and temporomandibular joint September 2019 11. Pharynx and Larynx 12. Blood supply to the Head and Neck: an overview 13. Embryology

Required reading: Clinically Oriented Anatomy, 4th or 5th Ed. Moore & Dalley, Lippincott William and Wilkins Or Clinical Anatomy for Medical Students, Snell

Additional literature:

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

85 Ben-Gurion University of the Negev International Medical School (MISH)

Name of the course: Anatomy of the Limbs Number of course: 481-8-2067

BGU Credits: Course Description: 4.5 Aims of the course ECTS credits: Number of credits in the Limbs Anatomy focuses on the functional arrangement of the skeletal muscles, the vessels and nerves that supply them, and the bony framework that both European Credit Transfer System facilitates movement and is composed of the principle objects being Academic year: moved. Special emphasis is placed on joints and on traumatic, chronic inflammatory and other pathologic processes that disturb normal function. 2019-20 Semester: Short introduction to the structures of the vertebra are given in the course. The rest of the course focuses on the upper and lower limbs. 2nd Hours of instruction: 62 Overall, the upper limb is presented as two collaborating and functional units: The arm/forearm, whose function it is to position the 2nd and key unit, the Lectures: 35 hours hand/fingers. Understanding the hand and protecting or restoring its function Labs: 27 hours then is possibly the most important goal of the physician treating pathology of the upper limb. A surgeon specializing in pathology of the hand and fingers will Tutorials: NA lecture on this subject.

Similarly the healthy lower limb functions to allow efficient mobility, enabling the Location of instruction: individual to achieve proximity to some item or person to permit use of the Faculty of Health Sciences hand/fingers on it. Understanding the mechanics involved in walking, therefore, classrooms, Deichman Bldg. will be another key element of the course. For this purpose, a physical therapist with an expertise in gait mechanics has been recruited for a detailed review of the subject. Language of instruction: English Dissections follow the subjects covered by that days lectures and will be performed by the students themselves, assisted by staff and TA’s from yrs. 4, 5 Cycle: and 6 of the Israeli track. 4th Position: Objectives of the course: Mandatory system To provide students with a deep knowledge of anatomy the limbs and vertebra. Field of Education: MD Learning outcomes of the course: On successful completion of the course, the Responsible department: student should be able to: MSIH 1. Knowledge of structure and function of limbs and vertebra 2. The capability to implement this knowledge in understanding of General prerequisites: pathologies involving the limbs or the vertebra Successful completion of all prior courses Attendance regulation: Lectures – recommended Grading scale: Dissections – mandatory Honors/Pass/Fail

Teaching arrangement and method of instruction: Frontal lectures Tutorials in small groups Dissection labs

86 Ben-Gurion University of the Negev International Medical School (MISH)

Coordinating Lecturer: Assessment: Prof. Yoram Etzion Compréhensive Examinassions: Written Component) 50% Contact details: Lab Component 50% Office phone:

08-6479987 100%

Email: [email protected] Work and assignments: Attendance at lectures; attendance at dissections; self-study at home and in dissection room Office hours: TBA at first lecture Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: Course evaluation: One day in the middle of the course is scheduled for self-study – 8 hours. Course debriefing after the exam One extra day is scheduled for self-study in the end of the course before the exam. In addition, self-study in dissection room on evening hours is allowed and encouraged. Confirmation: The syllabus was confirmed by the Module Content\ schedule and outlines: faculty academic advisory Lectures: committee to be valid on 2019-20 1. Vertebral column 2. Superficial back 3. Shoulder/Brachial Plexus Last update: September 2019 4. Axilla 5. Arm 6. Elbow/forearm 7. Wrist/hand 8. Hand 9. Deep back 10. Hip/gluteal 11. Thigh 12. Knee 13. Leg 14. Ankle 15. Foot 16. Imaging 17. Clinical correlations

Required reading: If more than one, either is acceptable: Clinically Oriented Anatomy, Moore, K.L. (Williams and Wilkins) Clinical Anatomy for Medical Students, Snell, R.S. (Little Brown)

Atlas (one) Grants Atlas of Anatomy, Agur, A.M., (Williams and Wilkins) Regional Atlas of the Human Body, Clemente (Lea & Fibiger) Color Atlas of Anatomy, Rohan & Yokochi (Igaku-Shoin) Atlas of Human Anatomy, Netter, F. (Ciba-Geigy)

Dissector: Grants Dissector, Sauerland, E.K., 10th ed. (Williams and Wilkins)

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 87 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Cardiovascular System Number of course: 481-8-2021 erer

BGU Credits: 10.5 Course Description: Aims of the course: ECTS credits: The course is designed to imbue the students with an all-round knowledge of the normal and diseased cardiovascular system, based on the fundamentals of physiology, histology and pathology, by means of frontal lectures, laboratory Academic year: 2019-20 work and computer simulations in physiology, problem-based case discussions and ECG exercises.

Semester: 1 Objectives of the course: Building on fundamentals, each of the main areas of clinical cardiology are Hours of instruction: 140 taught, including, valve disease, pericardial and myocardial disease, congestive heart failure and ischemic heart disease (from a subcellular level to clinical syndromes). The electrical system of the heart is discussed, also from a Location of instruction: Faculty of subcellular level to clinical arrhythmia and conduction defects, including lectures Health Sciences classroom on the principles of the ECG and exercises in ECG. Various imaging techniques used in cardiology are presented, from older, established ones to newer Language of instruction: English developments. There is also some input on molecular cardiology and international aspects of cardiology. Some pharmacology is taught in the context of specific disease states. Cycle: 1st

Other subjects include congenital heart disease, preventive aspects of cardiology, Position: System, obligatory interventional cardiology and cardiovascular surgery. Towards the end of the course, there's a clinical session discussing hospitalized patients on the coronary care unit. Field of Education: MD Learning outcomes of the course: On successful completion of the course, the

Responsible department: MSIH student should be able to: 1. Understand the physiological basis of the function of the normal cardiovascular system. General prerequisites: Successful 2. Understand how different pathologies are expressed in the cardiovascular completion of all prior courses system. 3. Interpret an ECG, demonstrate knowledge of the clinical presentations of Grading scale: Honors/Pass/Fail cardiovascular disease, investigations performed, and recommended therapies.

Attendance regulation: All clinical lectures - mandatory Computer simulations – mandatory All case discussions (including clinical, PBL, TBL) - mandatory Labs - mandatory

Teaching arrangement and method of instruction: Frontal lectures, clinical case presentations and problem-based learning given to the whole class; computer simulations in physiology, lab sessions in pathology and histology, and ECG exercises, presented to smaller groups.

88 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Jean Marc Weinstein Assessment: Contact details : NBME exam and lecturer-based questions– 80% Class presentations – 12%, Pre-tests (Prof. Henkin) 8% the marks of which count towards the students' final Office phone : 052-2707697 overall mark for the course. The students also have 2 days free before the concluding exam, in which to complete their revision prior to the exam.

Email: jmwein @bgu.ac.il Course Content\ schedule and outlines: Lectures: Office hours: The lecturer is available 1. Histology of the cardiovascular system to answer queries by email at all 2. Pathology of the cardiovascular system times, either directly from students 3. CV Physiology –partly Self-study or via the offices of the School. 4. Endothelium and plaque rupture – Self study 5. Imaging in cardiology 6. New Imaging Techniques in Cardiology Course evaluation: 7. Myocardial disease Honors/Pass/Fail 8. ECG 9. Endocarditis 10. Pericardial disease Confirmation: 11. RAAS – self study 12. Mitral Valve Disease July 2019 13. Congenital heart disease 14. Aortic Valve Disease 15. Acute Myocardial Infarction Last update: 16. Chronic Ischemic Heart Disease July 2019 17. Acute Coronary Syndromes 18. Congestive Heart Failure 19. Arrhythmia 20. Interventional cardiology 21. Cardiac surgery 22. Molecular Cardiology

Required reading: Harrison's Principles of Internal Medicine EKG, Dubin

Additional literature: Both available through the BGU Medical library internet site.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

89 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Clinical and Communication Skills 1&2 Number of course: 481-8-2060/2061

BGU Credits: 2.75 Course Description: Aims of the course: ECTS credits: The primary aim of the course is to provide students with practical training in Clinical Hebrew in small groups - of as uniform a level of Hebrew as we can achieve - using role-play at first and graduating to interviewing and examining Academic year: 2019-20 real patients on the wards, under the tutelage of BGU program students. The course also includes, an introduction to the basics of physical examination, an Semesters: 1&2 inseparable part of medical diagnostic procedure. Additionally, you will meet in larger groups every few weeks and simulate interviews, diagnostic thinking and case presentation. Hours of instruction:

Location of instruction: Objectives and learning outcomes: Faculty of Health Sciences classrooms 1. Prepare MSIH students to communicate in Hebrew on the wards with a clinical orientation of the vocabulary involved. 2. Improve ability to re-organize the information from basic sciences Language of instruction: English and through clinical sciences to “systems”, and apply it to patient Hebrew interactions. 3. Improve examination skills 4. Improve development of the differential diagnosis Cycle: 1st and 2nd

Attendance regulation: Mandatory Position: Mandatory course

Teaching arrangement and method of instruction: Field of Education: MD a. The course is considered a clinical course (like a clerkship) and thus attendance is compulsory and will be monitored by the TAs. Exemptions Responsible department: MSIH from sessions are to be coordinated with your small-group tutor after getting permission from Dvir Gatt (or Ron Charach, if Dvir is unavailable). b. Lessons will take place on the 6th floor and on the wards' staffrooms. We General prerequisites: Successful shall aim to make the location constant for each small group. completion of 1st cycle c. Every 3-4 weeks there will be physical examination lessons. During these lessons the emphasis will be both on technique and on communicating with patients in Hebrew during the physical exam. Grading scale: Honors/Pass/Fail d. The booklet for clinical Hebrew will be distributed and is helpful. e. The textbook for physical examination is "Bates’ guide to physical examination and history taking" 11th edition- available from the medical library in the grounds of Soroka.

90 Ben-Gurion University of the Negev Medical School for International Health

Lecturers: Assessment: Teaching assistants a. The final grade will be composed of tutor assessments for each semester, Course Coordinators: based on parameters reflecting motivation, effort and involvement, as well as Dr. Ron Charach a global assessment of improvement. b. OSCE with a number of Hebrew skills stations, and stations assessing Physical Dr. Dvir Gatt Examination.

Contact details: Required reading: Mobile phone: Textbook: Dr. Charach: 054- 8006778 "Bates’ guide to physical examination and history taking" 11th edition- available Dr. Gatt: 054-4214040 from the Soroka library. Email: [email protected] [email protected]

Office hours:

Course evaluation: Online student survey and debriefing at the end

Confirmation: The syllabus was confirmed by the faculty academic advisory committee to be valid on August 2019

Last update: 2019-20

91 Ben-Gurion University of the Negev Medical School for International Health Course Content: Colors and WH questions Body parts

Symptom characterization Comprehensive history taking: the adult patient

Cardiology Respiratory Gastroenterology Neurology Nephrology Endocrinology & Diabetes Rheumatology Pediatrics Obstetrics and Gynecology Clinical words Physical examination Cardiovascular system – physical examination Respiratory system – physical examination Abdomen – physical examination Nervous system – physical examination

All learning material will be available to the students on the course's website Moodle/ library/ electronic documents available to BGU students.

92 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Embryology 1 & 2 Number of course: 481-8-2020

BGU Credits: 0.75 Course Description:

Aims of the course: ECTS credits: The Human Embryology course teaches medical students the embryonic development of the major organ systems and associated congenital Academic year: 2019-20 abnormalities. The Embryology course is studied in parallel with the relevant Human Anatomy material.

Semesters: 1 & 2 Objectives of the course: The goal of this integrated approach is to help the students gain a better understanding of Anatomy. In addition to descriptive embryology, which teaches Hours of instruction: 10 the dynamics of morphogenesis and organogenesis, the course introduces the underlying molecular mechanisms, i.e., the genetic programs that regulate Location of instruction: developmental processes. This helps the students understand both the origins of Faculty of Health Sciences classroom individual birth defects and of congenital syndromes with diverse and apparently unrelated phenotypes, such as Kartagener’s or velocardiofacial syndromes. Language of instruction: English Learning outcomes of the course: Cycle: As for anatomy courses On successful completion of the course, the student should know: 1. Basic events in embryonic development Position: Mandatory 2. Developmental principles of organ systems 3. Basics of major congenital disorders Field of Education: Medicine 4. Relevance of embryology research for regenerative medicine

Responsible department: MSIH Attendance regulation: Not obligatory General prerequisites: Successful completion of all prior courses Teaching arrangement and method of instruction: Frontal lectures Grading scale: Honors/Pass/Fail

93

Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. C. Brodski Assessment: Contact details : Integrated with the Anatomy exams Office phone: 647-77320

Work and assignments:

Email: [email protected] 2 hour exercise: The essential impact of understanding the molecular mechanisms of embryogenesis for developing new therapies in regenerative medicine

Office hours: TBA Time required for individual work: In addition to attendance in class, the students are expected to do recapitulate the Course evaluation: material presented in class. Debriefing at completion of anatomy courses.

Confirmation: 2019-20 Course Content\ schedule and outlines: 1. Embryonic Period Last update: August 2019 2. Fetal Period 3. Development of the cardiovascular & respiratory system 4. Development of the digestive system I 5. Development of Head & Neck

Required reading:

Langman's Medical Embryology, ed. T. W. Sadler, 10th Eds. or higher Moore & Persaud - The Developing Human

Additional literature:

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 94 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Gastrointestinal System Number of course: 481-8-2026

BGU Credits: 12 Course Description: Aims of the course: ECTS credits: Gastroenterology is a system of Internal Medicine and has a close interface with surgery. It entails both empathetic individualized patient care and advanced technology using invasive procedures. It is multifaceted, involving inflammatory, Academic year: 2019-20 infectious, neoplastic, auto-immune, metabolic and functional disorders and includes the biliary System and the liver. Semester: 1 Objectives of the course:

Hours of instruction: 98 The course will include sessions devoted to discussions of case studies that emphasize a clinical approach to Gastrointestinal (GI) problems. Lectures and laboratories cover subjects such as: Location of instruction: Physiology of the GI tract; GI diseases and cancer; maldigestion and Faculty of Health Sciences classroom malabsorption; diseases of the pancreas and liver; drugs and metabolism, acute gastroenteritis, oral rehydration Language of instruction: English The course will include a visit in the GI department to see endoscopy procedures. Cycle: 1st

Communication will be based mostly on Moodle – schedule changes, Position: Mandatory system presentations, forum for discussion, recommended web sites.

Learning outcomes of the course: On successful completion of the course, the Field of Education: MD student should be able to: 1. Demonstrate familiarity and understanding of normal gastrointestinal Responsible department: MSIH physiology. 2. Demonstrate basic knowledge in the main pathologies of gastrointestinal General prerequisites: tract and liver diseases. Successful completion of all prior 3. Demonstrate understanding of the pathophysiology, clinical courses. manifestations, diagnosis and management of major gastrointestinal diseases. Grading scale: 4. Recognize, know, and understand the cellular basis, pathophysiology, diagnosis and management of common liver diseases. Honors/Pass/Fail 5. Demonstrate familiarity with the main imaging modalities used in gastroenterology.

Attendance regulation: Lectures – optional Case studies – mandatory Labs - mandatory

Teaching arrangement and method of instruction: Frontal lectures/learning units for self-study /groups/student presentations

95 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Naim Abu-Freha Assessment: Contact details : NBME exam – 80% Office phone : 054-5428538 Attendance – 10% In-class presentation – 10% Email: [email protected] [email protected] Work and assignments: One presentation Office hours: TBA Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: Students are required to study and review the lectures at home, roughly 30mins Course evaluation: per hour lecture. Debriefing held at the end of the Module Content\ schedule and outlines: system Lectures: 1. Esophageal Disease Confirmation: 2. Histology August 2019 3. Pathology 4. GI malformation 5. Tumor of Esophagus and Stomach Last update: 6. Pathology August 2019 7. GI bleeding 8. Peptic Ulcer Dis. & Pharmacology 9. Colorectal cancer 10. Treatment of GI Cancer 11. Malabsorption 12. Disease of the Pancreas 13. IBS 14. IBD 15. Celiac 16. Liver Function & Cholestasis 17. Acute Viral Hepatitis 18. Drug Related Disease 19. Acute Gastroenteritis 20. Chronic Liver and Cirrhosis 21. Hormone secreting tumors 22. Alcoholic and Non Alcoholic liver Disease

Required reading: 23. Principles of Physiology – Berne Levy 24. Textbooks of Internal Medicine – Cecil or Harrison’s 25. http://www.mdconsult.com/public/book/view?title=Goldman:+Goldman' s+Cecil+Medicine 26. Gastroenterology & Hepatology, Mayo Clinic Board Review 27. Additional reading is listed extensively on the Moodle website.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

96 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Integration of the Basic Sciences (USMLE Review) Number of course: 481-8-2024

BGU Credits: 1.4 Course Description:

ECTS credits: Objectives of the course: The objectives of the integration of basic sciences course is to give the students an opportunity to review the basics of the biomedical sciences and incorporate Academic year: 2019-20 that knowledge into their understanding of the human systems.

Attendance regulation: Semester: 2 Optional with a minimum of 8 students in attendance

Hours of instruction : 18 Teaching arrangement and method of instruction:

Location of instruction: Review sessions, case discussions and a question and answer format. Faculty of Health Sciences classroom.

Language of instruction: English Assessment: Cycle: 1st Summative practice NBME exam Position: Mandatory course The final grade for the course is 750 Field of Education: MD Time required for individual work: Responsible department: MSIH In addition to attendance in class, the students are expected to do … General prerequisites: Basic science courses of 1st and 2nd Course Content\ schedule and outlines: year Practice USMLE questions according to subject:  Ethics Grading scale:  Biostatistics and epidemiology review  Pass/Fail Quality assurance in health care  Physiology review  Biochemistry review Lecturer:  Microbiology review Dr. Marcel B. Ramer One practice voucher Office phone: Email: TBA Required readings: Office hours:

To be announced at the first session.

Course evaluation: Debriefing at completion of the course

Confirmation: September 2019 Last update: January 2019

97

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. Ben- Gurion University of the Negev Medical School for International Health

Name of the course: Nephrology System Number of course: 481-8-2027

BGU Credits: 7 Course Description: Introduction to clinical nephrology

Aims of the course: ECTS credits: To introduce students to basic principles and practices of nephrology and hypertension.

Academic year: 2019-20 Objectives of the course: The first part of the course provides the anatomic, physiological and Semester: 2 pathophysiological background for dealing with renal disease and hypertension. Topics include renal circulation, glomerular and tubule structure and function, Hours of instruction: 93 electrolyte and water handling by the kidney, the renin-angiotensin-aldosterone system, electrolyte disturbances, hypovolemia and hypervolemia, hyperosmotic and hypo-osmotic disorders and metabolic acidosis and alkalosis. Location of instruction: The second part provides an extensive coverage of the clinical spectrum of kidney Faculty of Health Sciences classroom disease and hypertension. Topics include renal pathology, immunology of renal disease treatment, imaging of the urinary tract, nephritic syndrome, nephrotic Language of instruction: English syndrome, interstitial renal disease, cystic renal disease, acute kidney injury, chronic kidney disease, renal replacement therapy (dialysis), kidney transplantation, primary and secondary hypertension, urinary tract infection and Cycle: 1st urinalysis.

Learning outcomes of the course: On successful completion of the course, the Position: Mandatory system student should be able to: 1. Understand normal function of the nephron. Field of Education: MD 2. Be familiar with methods of assessment of renal function and pertinent laboratory tests used to evaluate renal disorders Responsible department: MSIH 3. Integrate renal function as part of systemic regulation of extra- and intracellular fluid volume. Specifically, the differential roles of sodium and water in regulating different fluid volumes are clarified. The student will be General prerequisites: Successful able to assess disturbances of water and sodium metabolism and treatment completion of all prior courses. strategies will be exposed. 4. Discern potassium metabolism from sodium metabolism and be aware of the Grading scale: Honors/Pass/Fail significant differences in management of their disturbances. 5. Evaluate renal contribution to the regulation of systemic acid base homeostasis. 6. Understand the role of the kidney as both a source and a target organ of effector molecules affecting calcium and phosphate metabolism. 7. Differentiate between acute and chronic renal failure, their causes, complications and management. 8. Apply clinical, laboratory and ancillary immunologic diagnostic testing to develop a differential diagnosis of kidney diseases presenting as nephritic or nephritic syndrome.

Attendance regulation: Lectures –80% mandatory attendance Case-based discussions - mandatory Day tour-mandatory Urinalysis lab - mandatory

98 Ben- Gurion University of the Negev Medical School for International Health

Course director: Dr. Adi Leibe Teaching arrangement and method of instruction: Contact details:  33 teaching units  Day tour to University Hospital, meeting with Palestinian Nephrologists, Introduction to PAIRS activity (Palestinian And Israeli Renal Society), Office phone: International Nephrology, Ethics in Nephrology, Tour in dialysis unit etc. Email: [email protected]  Case discussions, answering USMLE 1 questions Office hours: Assessment:

Course evaluation: Online student 3 quizzes: 30% survey and debriefing on completion NBME: 70% of course. Work and assignments:

Confirmation: Students are expected to self-study the relevant material that will be assigned to each section and prepare for flipped classroom, case-based discussions and 2019-20 seminars. Presence in classroom for all these activities is mandatory. Students will be expected to prepare seminars and present them in class. Last update: October 2019 Course teaching units: 1. Renal Vasculature – Structure and Function 2. Glomerulus – Structure and Function 3. Tubular Networks – Structure and Function 4. Interstitium – Structure and Function 5. Sodium Handling by the Kidney 6. Hyponatremia, Hypernatremia 7. Water Handling by the Kidney 8. Hypovolemia/Hypervolemia 9. Potassium Handling by the Kidney 10. Hypokalemia/Hyperkalemia 11. Calcium & Phosphor Handling by the Kidney 12. Hypo/Hypercalcemia & Hypo/Hyperphosphatemia 13. Renal Hydrogen & Chloride handling 14. Acid-Base Disorders – Emphasis on Metabolic Acidosis and Alkalosis 15. Complex Electrolyte Disturbances 16. Pathology of Glomerular Disease 17. Glomerulonephritis 18. Nephritic Syndrome 19. Nephrotic Syndrome 20. Pathology of Interstitial and Tubular Disease 21. Interstitial & Cystic Disease of the Kidney 22. Acute Kidney Injury 23. Chronic Kidney Disease 24. Hypertension – Essential and Secondary 25. Drugs and the Kidney 26. Immunosuppressive Rx of Kidney Disease 27. Fluid Overload & Diuretics 28. Imaging of the Urinary Tract 29. Urinary Tract Infection 30. The Kidney as an Endocrine Organ 31. The Renin-Angiotensin-Aldosterone system 32. Renal Replacement Therapy 33. Kidney transplantation 34. Ethical Issues in Nephrology 99 Ben- Gurion University of the Negev Medical School for International Health

Required reading: Students should prepare before each lecture by reading the relevant chapters from:

Harrison's Principles of Internal Medicine, 20th Edition, 2018 Section 7 , Alterations in Renal and Urinary Tract function 285-324 Part 9, Disorders of the Kidney and Urinary Tract 2089-2177 Chapters 271, 272, 1890-1910 (Hypertension, Renovascular Hypertension)

Renal Physiology, Elsevier, Mosby Physiology Series, Bruce Koeppen, Bruce Stanton, 2019 The entire book in accordance with the Syllabus

Nephrology Secrets, Edgar Lerma, Mathew Sparks, Joel Topf, Elsevier, 2019 The entire book in accordance with the Syllabus Last 2 books have Digital versions

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

100 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Neuroanatomy Number of course: 481-8-2028

BGU Credits: 3.75 Course Description: ECTS credits: Aims of the course: The course provides an in-depth overview of neuroanatomy with special emphasis on relationships to both normal human function and dysfunction resulting from maldevelopment or injury to the nervous system. Academic year: 2019-20 Objectives of the course Semester: 2 The objective of the course is to provide the student with basic knowledge on the organization, function and pathology of the central nervous system. The student will learn the basis for further clinical studies in neurology and neurosurgery. Hours of instruction: 41 hours lectures Learning outcomes of the course: On successful completion of the course, the 18 hours of exercises student should be able to: Location of instruction: Faculty of 1. Demonstrate knowledge of the structure, topography and function of Health Sciences classroom the brain and spinal cord. Language of instruction: English 2. Demonstrate a basic understanding of brain topography and functional anatomy of the motor and sensory pathway. 3. Understand the higher cerebral function such as language and emotions. Cycle: 1st

Attendance regulation: Position: Mandatory system Lectures: Mandatory Exercises: Mandatory

Field of Education: MD Teaching arrangement and method of instruction: Frontal lectures; groups Responsible department: MSIH

General prerequisites: Assessment: Successful completion of all prior 40% practical examination courses 60% written exam – Multiple Choice Test and/or NBME test Grading scale: Honors/Pass/Fail

101 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Yuval Sufaro Course Content\ schedule and outlines: Contact details : 1. Organization of the central nervous system, meninges, brain Office phone: ventricles. Cerebro-spinal fluid (CSF), production, flow and Email: [email protected] absorption. 2. Surface anatomy of the brain hemispheres, function of the different gyri and sulci. Broodman map and its relation to the Office hours: functional areas. TBA 3. Vasculature – Arterial supply of the scalp, meninges and brain. Anterior and posterior circulation, Venous drainage, veins and Course evaluation: Online survey and debriefing sinuses. meeting with student 4. Midbrain – tectum, cerebral peduncle, substantia nigra, reticular representatives, course coordinator, formation, crus cerebri, inferior colliculi, tegmental and inter- and MSIH Academic Coordinator peduncular nuclei, trochlear nerve. 5. Pons (Metencephalon) – general, surfaces; rostal pons, dorsal Confirmation: and ventral parts; caudal pons – dorsal and ventral parts; The syllabus was confirmed by the syndromes. faculty academic advisory 6. Medulla oblongata – anterior and posterior surfaces, cranial committee to be valid in 2019-20. nerves nuclei and tracts located in the medulla oblongata; medullary syndromes. Last update: 7. Spinal Cord – general description, descending & ascending tracts, August 2019 cytoarchitecture of the gray matter, blood supply to the spinal cord, injuries to the spinal cord, clinical manifestations. 8. Lymbic system- structures, tracts, function and its relation to autonomic and emotional response. 9. Cranial nerves - origin, course, function and impairment. 10. Visual system- optic nerves, optic tracts, brain stem nuclei related to the visual system, control of eye movement, visual fields and visual cortex. 11. Basal ganglia- structures, tracts and function. Interaction with the cerebral cortex and control of the motor system. 12. Cerebellum- structures, nuclei, tracts and function. Interaction with the cerebral cortex, brain stem and spinal cord. Regulation of the motor system. 13. Thalamus- thalamic nuclei, their function, connections to the cortical and subcortical areas, afferent and efferent fibers from an to the thalamus. 14. Autonomic system- sympathetic and parasympathetic pathways, the control on autonomic functions, neurotransmitters. 15. Auditory and vestibular systems, the related nuclei and tracts, the transmission of mechanical energy to electrical one.

Required reading: Neuroanatomy through clinical cases. Hal Blumenfeld, 2nd Ed.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

102 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Neurology System Number of course: 481-8-2098 Psychiatry: 481-8-2095 BGU Credits: 6 Course Description: Essentials of clinical neurology ECTS credits: Aims of the course: Academic year: 2019-20 Introduction to the neurological system and its main disorders.

Semester: 2 Objectives of the course: Neurology Hours of instruction: 78 The objectives of the Neurology part of the system are:  Highlighting of selected aspects in neuroscience and molecular neurology.  Theoretical basis for the clinical neurology clerkship; principles of localization Location of instruction: and neurological diagnosis; pathophysiology of neurological dysfunction. Faculty of Health Sciences classroom  Teaching is based on frontal lectures and self study. Some of the lectures given are problem-oriented. The students are Language of instruction: English required to prepare pre-given cases. The cases are discussed and clinical issues are highlighted. Cycle: 1st Learning outcomes of the course: On successful completion of the course, the student should be able to: Position: Mandatory system 1. Know the principle neurological disorders. 2. Localize lesions in the different parts of the neurological system. Field of Education: MD 3. Assess a patient according to neurological principles and thinking. 4. Plan proper investigation and treatment for common neurological Responsible department: MSIH disorders.

Attendance regulation: General prerequisites: Successful Lectures: Mandatory completion of all prior courses

Teaching arrangement and method of instruction: Grading scale: Honors/Pass/Fail Frontal lectures, self study.

Assessment: NBME exam

Work and assignments: Active class participation Pre-class understanding of the seminar cases, their differential diagnoses, syndrome features and possible medical workup for the case.

103 Ben-Gurion University of the Negev Medical School for International Health

Coordinator: System Content\ schedule and outlines: Dr. Michael Star 1. Introduction to clinical neurology, 2. Neurological examination and localization, Contact details : 3. Neurology of pain, [email protected] 4. Headaches, 5. Spinal cord syndromes, 6. Multiple sclerosis and neuro-immunology , Office hours: 7. Epilepsy, TBA at first lecture 8. Degenerative neurological disorders, 9. Movement disorders, Course evaluation: 10. Diseases of the peripheral nervous system, Online student survey and end of 11. Diseases of the neuromuscular junctions, course debriefing 12. Neuropathies and myopathies, 13. Motor neuron diseases, Confirmation: 14. Cerebrovascular disorders, 15. Viral and bacterial infections of the CNS, 2019-20 16. Intracranial pressure, 17. Tumors in the CNS, Last update: 18. Intra-cranial hemorrhages, February 2019 19. CNS trauma, states of consciousness, 20. Metabolic diseases of the nervous system, 21. Imaging, 22. Dementia and disorders of high cortical function, 23. Paraneoplastic, 24. Neuro-, 25. Attention deficit disorder, 26. Sleep disorders.

Required reading: Clinical Neurology, Greenberg, Aminoff and Simon (digital available)

Recommended reading:

Copies are in the medical library.

Additional literature: Adams and Victor's Principles of Neurology 10th Edition Harrison's Principles of Neurology

104 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Practicing global health in specific contexts

- Number of course: 481-8-2070

BGU Credits: 2 Course Description: Based on the knowledge acquired in the introductory Global Health course, the current course will focus on specific health issues in the communities in which the students are expected to carry out ECTS credits: their clerkships (Nepal, India, Ghana, etc). The impact of historical, political, economic and socio- cultural determinants of health will be considered. In addition, the practices and interactions of Academic year: providers from different sectors of health care in the specific countries and communities (traditional 2019-20 healers, midwives, Ayurveda, modern, etc.) as well as their impact on the health of local populations will be explored. Semester: 1st and 2nd Aims of the course 1. To enhance the students’ understanding of health issues in different environments and Hours of instruction: 26 socio-cultural contexts 2. To prepare students for their clerkship in specific communities Location of instructionTo prepare: Objectives of the course 1. To increase students' understanding of the determinants of health Language of instruction: 2. To strengthen students' abilities of utilizing community profiling methods and culture English sensitive interviews 3. To enhance the understanding of parallel health systems in countries which are Cycle: MSIH economically and socially different than their country of origin 4. To promote a culture and gender sensitive approach to global health issues in specific contexts Position: Mandatory

Learning outcomes of the course: Field of Education: MD On successful completion of the course, the students should be able to:

Responsible department: 1. Apply skills acquired to promote a community based, culture and gender sensitive approach to MSIH health care 2. Cope with challenges and dilemmas related to values and beliefs different than their own while General prerequisites: dealing with health issues in specific contexts 3. Use Kleinman’s Explanatory Model as a basis to explore and understand patient’s beliefs, Grading scale: perceptions and practices 4. Enable professional networking and knowledge-sharing skills to enhance medical practice in Pass/Fail specific cultural contexts

Teaching arrangement and method of instruction: 1. Interactive lectures, including discussion of case studies and video clips 2. Group work and development of simulations based on dilemmas and challenges related to global health issues in specific contexts, guided by teacher assistants 3. Guest lecturers and student presentations and discussions

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Lecturer: Dr. Anita Nudelman Attendance regulation: Mandatory

Contact details: Assessment: 30% Class attendance and participation 30% Community profiling, health system analysis and health issue assignments and EM Office phone : interview 30% Simulations related to global health dilemmas and challenges, including Email: [email protected] report [email protected] m Work and assignments: The class will work in groups, focusing on the different countries and communities (clerkship sites). They will prepare short presentations and simulations followed by discussions. The Office hours: by previous th arrangement final presentation will take place during the workshop with 4 year students returning from their clerkships

Course evaluation: Debriefing at completion Time required for individual work: course In addition to attendance in class, the students are expected to work on readings and assignments, 4-6 hours between monthly classes (including meetings with TAs) Confirmation: Course Content: August 2019 1. The socio-ecological approach to health in the global context 2. The sectors of health care: popular, traditional, alternative, professional. The Last update: 19.8.19 interaction of parallel health systems in specific country contexts 3. Community profiling and health needs assessment 4. The Explanatory Model (Kleinman) and its contribution to provider patient interaction and culture competence in health care 5. Interdisciplinary research on health issues 6. Global health issues in specific contexts: analysis of case studies

Required readings: Helman C. (2007). Culture, Health and Illness, Fifth Ed., Taylor & Francis Group (selected readings).

Farmer P., Kleinman A., Yong Kim J. & Basilico M., Editors (2013). Reimagining Global Health: An Introduction. Univ. of California Press, 1st Edition (selected readings)

Biehl J. & Petryna, A., (2013). When people come first: Critical Studies in Global Health. Princeton University press (selective chapters)

WHO (2013). WHO Traditional Medicine Strategy: 2014-2023. http://www.who.int/medicines/publications/traditional/trm_strategy14_23/en/

Additional literature: Relevant articles will be recommended according to the communities/ countries and the specific health issues to be analyzed by the groups.

All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

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Name of the course: Psychiatry Number of course: 481-8-2095

BGU Credits: 6 Course Description: Aims of the course: ECTS credits: Psychiatry: The aim of the course is to equip the student with information base for the clinical clerkship and the medical career regarding clinical psychiatry, basic psychiatric concepts, language, diagnoses and some knowledge in psychology Academic year: 2019-20 and behavioral sciences.

Semester: 2 Learning outcomes of the course: On successful completion of the course, the student should be able to: Hours of instruction: 78 1. Conduct a basic psychiatric interview 2. Recognize a range of psychiatric conditions and understand the pharmacological treatment for each condition Location of instruction: 3. Demonstrate knowledge of the psychological evaluation of the child Faculty of Health Sciences classroom 4. Be familiar with aspects of geriatric psychiatry 5. Be familiar with aspects of psychiatric rehabilitation Language of instruction: English

Cycle: 1st Attendance regulation: 08.15-lunch break – mandatory Position: Mandatory All seminars - mandatory

Field of Education: MD Teaching arrangement and method of instruction:  Frontal lectures Responsible department: MSIH  Self-study is expected in the following cases: sexual abuse, substance intoxication, psychological defense mechanism found in the text below

General prerequisites: Successful Assessment: completion of all prior courses. NBME exam: 100%

Grading scale: Honors/Pass/Fail Work and assignments: Active class participation Pre-class understanding of the seminar cases, their differential diagnoses, syndrome features and possible medical workup for the case

Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work at home, spending roughly 30mins per hour lecture.

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Lecturer: Dr. Ari Lauden Course Content\ schedule and outlines:

Contact details: Subjects covered include the classification and diagnostic interview in psychiatry; schizophrenia and psychotic disorders; mood disorders; anxiety

Office phone: disorders; posttraumatic and adjustment disorders; psychotherapeutic and pharmacologic treatments; child, adult, and geriatric psychiatry; ADHD, Email: [email protected] sleep disorders, substance abuse and forensic psychiatry. Office hours: TBA at first lecture Required Course evaluation: Synopsis of Psychiatry, 10th or 11th Ed. Student online survey and debriefing Current edition; http://www.synopsisofpsychiatry.com at completion of course.

Confirmation: Additional literature: 2019-20 Textbook of Psychiatry B.K. Puri, P.J. Laking, I.H. Treasaden, Churchill Livingstone Current edition Last update: 2019-20 The Toronto Notes for Medical Students, 2010 Clinical Handbook, Psychiatry Chapter. McGraw-Hill Ed. First Aid to the Psychiatry Clerkship Case files for psychiatry Blueprint Case files for Psychiatry

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* All learning material will be available to the students on the course's website Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Reproductive System Number of course: 481-8-2079

BGU Credits: 4.6 Course Description: Aims of the course: ECTS credits: The Reproductive System course is an introduction to the clinical area of Obstetrics and Gynecology and Reproductive Medicine. It will also help you get acquainted with the rotation in the third year. Academic year: 2019-20 Objectives of the course: Semester: 2 To enable students to acquire basic understanding of human reproduction, maternal physiology during pregnancy, normal parturition, and infertility.

Hours of instruction: 60 Learning outcomes of the course: On successful completion of the course, the student should be able to: Location of instruction: 1. Describe normal sexual development of men and women Faculty of Health Sciences classroom 2. Demonstrate understanding of normal and abnormal sexual development 3. Understand the anatomy of the female reproductive system Language of instruction: English 4. Understand the anatomy of the male reproductive system 5. Understand the basic pathophysiology leading to malignancies of Cycle: 1st reproductive organs 6. Understand the process of a normal delivery, from pre-natal diagnosis through delivery Position: Mandatory system 7. Understand the causes of miscarriage 8. Be familiar with diseases associated with pregnancy, i.e. diabetes, infections, endometriosis Field of Education: MD 9. Be familiar with the underlying causes of amenorrhea and anovulation

Responsible department: MSIH Attendance regulation: 100% attendance at lectures is required. General prerequisites: Successful completion of all prior courses Teaching arrangement and method of instruction:

Grading scale: Honors/Pass/Fail Frontal lectures and case discussions

Assessment: NBME Exam: 100%

Time required for individual work:

In addition to attendance in class, the students are expected to do their assignment and individual work at home, roughly 30mins per hour lecture.

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Coordinator: Course Content\ schedule and outlines: Dr. Dorit Paz /Dr. Roi Kessous Lectures: 1. Menstrual cycle Contact details: 2. Endocrinology of Male Reproduction & Male Infertility Office phone: 3. Polycystic Ovary Syndrome Emails: 4. Implantation & Fertilization 5. Histology [email protected] 6. Normal & Abnormal Sexual Development Office hours: 7. Amenorrhea and anovulation Individual meetings can be arranged 8. Endometriosis via email. 9. Miscarriage and recurrent pregnancy 10. Parturition and post maturity Course evaluation: 11. Pre-term and post-term labor Online student survey at end of 12. Placental development and function system debriefing. 13. Diabetes in pregnancy 14. Ovarian cancer Confirmation: 15. Hypertensive disorders in pregnancy 16. Normal delivery 2019-20 17. Third trimester bleeding 18. Prenatal diagnosis Last update: Sept. 2019 19. Urinary incontinence 20. Maternal adaptation to pregnancy 21. Benign and malignant conditions of the uterine corpus 22. Obesity 23. Pathology 24. Fetal physiology Infectious disea

Required reading: Lange, Current diagnosis and treatment, Obstetrics and Gynecology, 10th Edition

Additional literature: Melmed: Williams Textbook of Endocrinolgy 12th ed (ebook on MDConsult) Both avalable through the BGU Medical library internet site.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

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Name of the course: Respiratory System Number of course: 481-8-2022

BGU Credits: 8 Course Description: Aims of the course: ECTS credits: The goal of the respiratory system is to introduce and teach basic principle and practice in pulmonology. Academic year: 2019-20 Objectives of the course:

Semester: 2 Objectives are to enable students to classify and acquire understanding of the process of breathing – oxygenation and ventilation, pulmonary clinical and pathological disorders, and to incorporate laboratory findings into clinical Hours of instruction: 105 problem solving.

Location of instruction: Learning outcomes of the course: On successful completion of the course, the Faculty of Health Sciences classroom student should be able to: 1. Demonstrate knowledge of embryology, histology and lung defense Language of instruction: English mechanisms 2. Demonstrate knowledge of basic and advanced lung physiology. Cycle: 1st 3. Describe respiratory diseases in adult and pediatric pulmonology. 4. Demonstrate knowledge of pulmonary function tests. Position: Mandatory system 5. Be familiar with mechanical ventilation

Field of Education: MD Attendance regulation: Lectures – 80% mandatory attendance Labs - mandatory Responsible department: MSIH

Teaching arrangement and method of instruction: General prerequisites: Successful Frontal lectures, groups completion of all prior courses.

Grading scale: Honors/Pass/Fail Assessment: Combined faculty written multiple choice questions and NBME web-based test to comprise 100% of the assessment.

Work and assignments: Students are required to take active part in class participation, clinical discussions and computer and physiology laboratories.

Time required for individual work: In addition to attendance in class, the students are expected to do their assignment and individual work at home, roughly 30mins per hour lecture.

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Lecturer: Dr. Micha Aviram Course Content\ schedule and outlines: Contact details : 1. Basic Science: Embryology; Histology; Lung Defense Mechanisms. Mobile phone: 0544-701413 2. Basic Lung Physiology: Structure and function relationship, Ventilation, Email: [email protected] Perfusion, Gas Transport, Lung Mechanics ( Static and Dynamics) lung volumes and ventilation, Ventilation Perfusion mismatch, Respiratory Muscles, Pulmonary Circulation, Cardio-Pulmonary Relationship, Control of Office hours: breathing. TBA at the first lecture 3. Advanced Lung Physiology: Air and Fluid in Pleural Space, Exercise Physiology, High altitude Physiology, Scuba Diving Physiology, Acid Base Physiology. Course evaluation: Honors/Pass/Fail 4. Respiratory Diseases Adult Pulmonology : Chronic Obstructive Pulmonary Disease (COPD); Interstitial Lung Disease (ILD), Asthma, Pneumonia; Tuberculosis, Confirmation: August 2019 Bronchiectasis and Lung Abscess, Lung Tumors: clinical and pathological aspects, Venous Thrombo-Embolism; Sarcoidosis, Acute Respiratory Distress Last update: August 2019 Syndrome (ARDS) Sleep-Related Disorders. Pediatric Pulmonology: Fetal adaptation to fetal life, Hyaline Membrane Disease , Bronchiolitis, Pneumonia, Cystic Fibrosis, Childhood Asthma, Sudden Infant Death Syndrome.

5. Pulmonary Function Tests (PFTs); Lung imaging. 6. Viruses in the Respiratory tract 7. Mechanical ventilation. 8. Visit to ICU's

Required reading: Respiratory Physiology: The Essentials 8th Ed. John B. West

Additional literature: Melmed: Williams Textbook of Endocrinolgy 12th Ed (ebook on MDConsult) Both available through the BGU Medical library internet site.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

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Name of the course: Rheumatology System Number of course: 481-8-2030

BGU Credits: 6 Course Description: The Rheumatology course is based on the fundamentals of histology, pathology, ECTS credits: biochemistry, immunology and therapy of various rheumatic diseases

Academic year: 2019-20 Aims of the course: Review the histology, pathology, biochemistry, immunology and therapy of rheumatic diseases Semester: 2nd

Learning outcomes of the course: Hours of instruction: 84 On successful completion of the course, the student should be able to: 1. Understand the pathogenic mechanisms of various autoimmune and Location of instruction: Internal Medicine, Bldg. Soroka rheumatic diseases Medical Center 2. Classify rheumatic diseases and to learn the diagnostic tools of rheumatic diseases Language of instruction: English 3. To know the various therapeutic modalities of rheumatic diseases

Attendance regulation: Cycle: 1st Lectures – mandatory Labs - mandatory Position: Mandatory system Teaching arrangement and method of instruction: Frontal lectures/lab/simulations Field of Education: MD The main areas of clinical rheumatology are taught including; seropositive (Rheumatoid Arthritis, systemic lupus erythematosus, systemic sclerosis, Responsible department: MSIH inflammatory myopathies and vasculitis), spondyloarthropathies (psoriatic arthritis, ankylosing spondilitis, and reactive arthritis), crystal-induced arthritis (gout, pseudogout), septic arthritis, degenerative arthritidies, fibromyalgia, General prerequisites: None nonarticular rheumatism and osteoporosis.

Grading scale: Other subjects included in the Rheumatology System are imaging of rheumatic diseases, nonsteroidal anti-inflammatory drugs, disease modifying anti-rheumatic Honors/Pass/Fail drugs, biologic therapies, and corticosteroids.

Assessment: Exam - 100% NBME

Work and assignments: 6 topics for self-study

Time required for individual work Students are required to review lectures and read

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Coordinator: Course Content\ schedule and outlines Prof. Mahmoud Abu-Shakra 1. Introduction Contact details: 2. Biochemistry – Self Study 3. Histology Office phone : 08-6403123 4. Immunology Email: [email protected] 5. Lupus 6. Rheumatoid arthritis Office hours : 7. Seronegative and reactive arthritis TBA at the first lecture 8. Scleroderma 9. Clinical approach to rheumatology Course evaluation: Debriefing at the 10. Pathology completion of the system 11. Vasculitis 12. Osteoarthritis 13. Fibromyalgia – Self Study Confirmation: 2019-20 14. Synovial fluids Last update: December 2019 15. Antiphospholipid syndrome 16. Familial Mediterranean Fever and Amyloidosis – Self Study 17. Soft tissue rheumatism 18. Crystal deposition disease 19. Imaging 20. Pharmacology 21. Osteoporosis 22. Osteomyelotis and septic arthritis – Self Study 23. Ideopathic inflammatory myopathies 24. Treatment of rheumatological disorders 25. Lyme Disease – Self Study 26. Sjogren Syndrome – Self Study

Required reading: Primer on Rheumatic Diseases, Klippel Additional literature:

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 114 Third Year Clinical Clerkships and Global Health

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Name of the course: Cross Cultural Medicine Workshop Number of course: 481-8-3030

BGU Credits: 1 Course Description Workshop to illustrate and promote discussion of cross-cultural medical issues. ECTS credits: Aims of the course:

Academic year: 2019-20 Exposure of students to different aspects of cross-cultural medical scenarios.

Objectives of the course: Semester: 2 Show students which cross-cultural issues may arise while working in a medical clinical environment and show possible solutions. Hours of instruction: 12

Learning outcomes of the course: Location of instruction: TBA On successful completion of the course, the student should be able to: Identify a cross-cultural issue  Postulate alternative solutions to the identified issue Language of instruction: English  Communicate an experience with others to solve cross-cultural problems

Cycle: 1st Attendance regulation: Mandatory Position: Mandatory Teaching arrangement and method of instruction: Field of Education: MD  Lectures  Exercise sessions with simulated patients  Group discussions Responsible department: MSIH  Practical involvement.

General prerequisites:

Grading scale: Pass/Fail

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Lecturer: Dr. A. Golan Assessment:

Contact details:  Mandatory attendance Office phone:  Active participation in all discussions, workshops, and practical sessions

Email: [email protected] Work and assignments: Active participation in all discussions, workshops, and practical sessions. Office hours: Time required for individual work: Course evaluation: In addition to attendance in class, the students are expected to actively participate Debriefing at completion of all in all discussions, workshops, and practical sessions. selectives.

Confirmation: 2019-20 Course Content\ schedule and outlines: Day 1 Last update: September 2019 8:30- 9:00 Introductions 9:00 – 10:30 My cultural object 11:00- 11:30 CHAT tool 11:30- 12:00 Effective use of a medical interpreter 12:00- 13:00 Lunch break 13:00-16:00 Case presentations: Students interviewing simulated patients 4 rotating groups - 45 minutes each. Group 1: HIV Group 2: Bulgarian worker Group 3: Post coital bleeding Group 4: Bedouin women with Cesarean section 16:00- 16:15 Summary

Day 2 09:00- 10:00 Truth telling in cultural perspective- 10:00- 12:00 Simulated patients interview: 2 groups rotating. 10:00-11:00 Child with Diarrhea 11:00-12:00 Asthma patient before discharge hope 12:00-12:30 Overview

Required reading:

Reimagining Global Health - Farmer

Additional literature: Literature re Global Health and Cross Cultural Communications

117 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Emergency Medicine - 2

Number of course: 481-8-3100

BGU Credits: 3.25 Course Description: The course focuses on teaching the emergency aspect of ECTS credits: Internal Medicine. It does so through frontal lectures and case discussions conducted by intensive hands-on practice of various skills and situations. Academic year: 2019-20

Semester: First Aims of the course: To provide students with necessary skills for assessing and treating emergency situations, emphasizing the common situations the students can encounter Hours of instruction: 65 during the Internal Medicine clerkship.

Objectives of the course: The course is designed to cover the formal ACLS course content and to practice it Location of instruction: to a level that will allow the students to pass the course evaluation. Remaining All activities will be located at the Deichman Building Emergency Medicine topics including Respiratory emergencies and manual skills, will give students a basis to practice clinical thinking, assessment, and treatment Language of instruction: of common situations they might see in any Emergency Dept. or Internal Medicine ward. English Learning outcomes of the course: Cycle: 2nd On successful completion of the course the student should be able to: 1. Initially assess an acutely ill patient, take a relevant history, and perform a focused physical examination. Position: 2. Provide an airway and ventilatory support for the patient Mandatory course 3. Manipulate manual monitor/defibrillator and external cardiac pacing 4. Identify and treat common ACLS emergencies 5. Identify and treat common internal emergencies Field of Education: 6. Perform as a team leader in an emergency setting MD Attendance regulation: Attendance is compulsory for all Emergency Medicine activities, unless stated Responsible department: MSIH otherwise by the course’s staff.

Teaching arrangement and method of instruction: General prerequisites: Successful The frontal lectures and case discussions will be held for the entire class. passing of years 1 and 2 The case discussions are designed to be interactive with the students, allowing them to practice clinical thinking. The practical skill stations and megacode sessions will be taught in small groups Grading scale: up to ~12 students Honors/High Pass/Pass/Fail Every scenario practiced by student is followed by a focused and targeted debriefing.

Assessment: 1. MCQ test -90% a. To be eligible for “ACLS Provider” certificate, the student must score at least an 80% on relevant AHA questions, and on the staff’s supplementary questions. 2. MCQ moodle exams throughout the course-10% 3. OSCE practical stations – Mandatory “pass” grade

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Lecturer: Guy Tal Time required for individual work:

Contact details: In addition to attendance in class, the students are expected to complete the Cell phone: reading material that will be published for them on the Moodle course site. Email: guy7 @post.bgu.ac.il Course Content Lectures: Course evaluation: 1. Introduction A digital feedback form will be 2. Pulseless Arrest available to students at Moodle site 3. ROSC+H's & T's of the course at the end of the 4. Advanced Airway course and a debriefing meeting. 5. ECG rhythm review 6. ECG 12 lead review Confirmation: 7. Advanced ECG interpretation The syllabus was confirmed by the 8. Cardiac Arrhythmias X 2 faculty academic advisory committee to be valid 2019-20 9. Conscious patient evaluation 10. Approach to the severely ill child 11. - CXR Last update: 15/06/2019 12. Point of care ultrasound

Case Discussions: 1. ACS/CHF Case discussion 2. Respiratory Emergencies Case discussion 3. Arterial blood gas

Practical Skills Stations: 1. NG tube 2. Foley Catheter 3. IO 4. IV access 5. Blood draw, IM & SC injections 6. ILS, AED 7. Advanced air way & capnography 8. Vital signs & Noninvasive positive pressure support 9. Monitor & ECG 10. Communication 11. Radiology CXR X 2 12. Point of care US – Lung, Shock

Megacode Drills Sessions: 1. Pulseless Arrest X 3 2. Cardiac Arrhythmias X 4 3. ACS / CHF X 2 4. Respiratory Emergencies X 2 5. “Put It Together” X 3

Required reading: 1. American Heart Association Guidelines, 2015 update (selected parts) 2. Tintinalli's Emergency Medicine, 8e (selected chapters) Additional reading: 1. New England Journal of Medicine – Videos in Clinical Medicine119 2. Rapid Interpertation 2 of EKG’s (6th edition), Dale Dubin Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Family Medicine Clerkship Number of course: 381-8-3072

BGU Credits: 6 Course Description: ECTS credits: Approach and hands on experience of family medicine including diagnosis and treatment of common medical problems, chronic illness care and follow-up, and Academic year: 2019-20 preventive medicine in the community-based setting.

Semester: 2 Aims of the course: A significant part of medical care in this era takes place within the community Hours of instruction: clinics. Many medical conditions are diagnosed and treated in the community. 4 weeks Medical care in the community setting differs from hospital based medicine: 32 hours of classroom instruction Ongoing family patient relationships, long-term approach and patient-centered 128 hours in clinical rotation approach. Becoming familiar and knowledgeable in family medicine is an integral part of medical education no matter what medical expertise you choose in the Location of instruction: future. Community health clinics in and Objectives of the course: around Be'er Sheva and Faculty of Health Sciences classrooms. This course is designed to equip you with knowledge of family medicine as it is practiced in Israel. There are topics which are included in family medicine and specifically in the shelf test at the end of this course, which are not part of FM in Language of instruction: English Israel. You are required to study these topics on your own.

Cycle: 1st Learning outcomes of the course: At the end of this rotation you will be expected to know: Position: Mandatory clerkship 1. History taking and medical examination of patients, in a problem-based and community context. Field of Education: MD 2. How to approach common signs and symptoms in the community setting, and to identify "red flags" and serious medical conditions that Responsible department: MSIH warrant immediate attention. 3. Preventive medicine guidelines and their application in the community. 4. Care of the chronic patient: diagnosis treatment and long term follow- General prerequisites: up. Successful completion of all prior 5. Methods of family assessment and their applications, and become courses/systems/clerkships familiar with the biopsychosocial approach. 6. Diagnoses and treatment of common medical problems in specialized medical fields such as: orthopedics, ophthalmology, dermatology, ENT, Grading scale: psychiatry. Honors/High Pass/Pass/Fail Attendance regulation: Attendance at the clinics is mandatory and required by the medical school. MSIH requires at least 80% attendance as part of the course requirements. If you are obliged to miss time at the clinic, you are required to complete the time missed at another time in coordination with your tutor.

Attendance of the lectures is also mandatory. If you have a specific problem, please contact the rotation coordinator personally.

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Coordinators: Dr. Teaching arrangement and method of instruction: During this 4 week rotation, each one of you will be assigned to a Family physician, Aviram Dunsky working in a primary care clinic. You will join the physician during his/her routine Dr. Smadar Rain work, interview patients, examine patients and discuss differential diagnosis and treatment. Before beginning your rotation you will receive the name, phone no., work address, and work hours of the doctor you are assigned to. Please make Contact details: contact with the family physician you are assigned to prior to the beginning of the Mobile phone: rotation, and make sure you know how to get to the clinic. Some of the clinics are in Be'er Sheva, and some are outside of Be'er Sheva in satellite towns which are 050-6998804 Dr. Dunsky reachable by public transportation. If you are not sure of your assigned clinic, 052-5236102 Dr. Rain doctor or how to get there, please contact the office.

Days at the clinic are: Sun., Mon., Tues. and Thurs. Email: On Wednesdays the group will attend lectures and seminars held at the faculty. [email protected] Assessment: [email protected] At the end of the four week rotation you are required to take the NBME test, an external exam, given by MSIH. Before the exam you will have time for self-study. The NBME shelf test consists of 30% of your grade, and 70% consists of evaluation Office hours: of your time at the clinics. Three assignments (1 genogram and 2 patient write- Every reasonable hour available ups) are to be handed in until the last day of the rotation. This is a mandatory part on mobile phone. of the course. An integrative and important part of this rotation is attendance at the clinics.

Attendance at the clinics and lectures will be taken into account as part of your Course evaluation: grade. Debriefing at completion of clerkship Work and assignments: 1. Family Genogram: Each student is required to interview and write up a family genogram of one of your patients in the clinic. Confirmation: 2019-20 The genograms will be presented and discussed during the lecture on “The Genogram and tools of family assessment”. For further details see attached pages.

Last update: 2. Chronic Disease: An important issue in Family Practice is treating patients with chronic disease and following them as their disease evolves. During the rotation December 2018 you will be required to present two patients with a chronic disease, including: diagnosis, medical history, psychosocial history, treatment (pharmacologic and other), complications, and the patient’s attitude and coping with the disease.

Your tutor can assist you in choosing a patient. One of the patients should have one or more of the following diseases: Diabetes Mellitus, hypertension, ischemic heart disease, dyslipidemia The second patient can have any chronic disease that you choose. You will present and discuss these patients during the lectures on Wednesdays. The presentation must be written and handed in according to the lecture schedule.

Time required for individual work: in addition to attendance in class, the students are expected to do their assignments and individual work.

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Clerkship Content\ schedule and outlines Course lectures: a. Introduction and orientation to family medicine b. Preventive Medicine c. Tools for Family Assessment d. Smoking Cessation e. Seminars/ Case presentations: a. Diabetes, hypertension, dyslipidemia, ihd. Each topic will be discussed in terms of diagnosis, tx, complications and long term follow-up and complications. b. Case presentation (free topics)

The cases will be written up and submitted to your tutor who will assist you in finding an appropriate patient to interview and present. You are expected to present the patient and his medical and psychosocial background, relevant medical problems and information: up-to-date and relevant to the patients' medical conditions. (i.e., knowing and presenting HTN guidelines for a patient with HTN) f. Asthma seminar g. Orthopedics workshop: shoulder, low back pain, knee h. Dermatology i. Common Eye dis. j. Palliative care k. Self-limiting dis. l. Women's health m. Breaking bad news.

The case presentations are to include:  Patient presentation, problem oriented (you may use a SOAP format), psychosocial background, broad medical background.  Theoretical up-to-date clinical information relevant to the patient's medical condition.

During the case presentations you must be prepared to present the theoretical background relevant to your patient. I.e.: Diabetes guidelines and treatment if your patient has diabetes.

Required reading: A complete list of readings is posted on the Family Medicine Clerkship Moodle site.

Additional literature Additional literature is posted on the Family Medicine Clerkship Moodle site.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

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Wednesday seminar schedules over the clerkship

Seminar 1: 1. Principles of Family Medicine 2. Self-limiting disease 3. Preventive medicine 4. Lower back pain 5. Dermatology in primary care

Seminar 2: 1. Chronic cough and asthma 2. Primary eye care

3. Case presentation and discussion: hypertension, Diabetes mellitus, dyslipidemia 4. Breaking bad news 5. Ob/gyn in family medicine

Seminar 3: 1. Genogram and tools for family assessment 2. Case presentation and discussion 3. Paliative care 4. Knee and shoulder 5. Smoking cessation 6. Summary and feedback

123 Ben-Gurion University of the Negev Medical school for International Health

Name of the course: Internal Medicine Number of course: 471-8-3200

BGU Credits: 17 Course Description: Basic clinical teaching course in Internal Medicine using the ECTS credits: Problem Oriented Record (POR) system. Academic year: 201 9-20 Aims of the course: Internal Medicine is the basis of a doctor's training. The goal Semester: 1 of teaching in internal medicine is understanding the clinical way of thinking along Hours of instruction: 10 weeks with increasing the student's medical knowledge and mastering the physical exam. Location of instruction:

Internal Medicine departments at Objectives of the course: Clinical thinking comprises a few stages including , Barzilai collecting information about the patient's condition by history and search of the Medical Center and Yoseftal Hospital patient's medical record, physical exam and relevant tests. While progressing in Language of instruction: English the course the student will gain tools that will enable him or her to process the information relevant to the patient's condition, while distinguishing the important Cycle: 1st information, defining the patient's problems and bringing to discussion any other Position: Mandatory clerkship problems including relevant differential diagnosis, discussing possible avenues for further diagnosis and developing a treatment program in order to deepen an understanding of the patient's problems (Problem Oriented Record) Field of Education: MD

Learning outcomes of the course: On successful completion of the course, the Supervising Department: Internal student should be able to: Medicine, Soroka University Medical 1. Complete an admission for an Internal medicine patient using POR and a Center complete physical exam 2. Present the patient both verbally and in writing Responsible department: MSIH 3. Discuss common problems in internal medicine, including differential diagnosis and basic knowledge of these diseases General prerequisites: Introduction to Clinical Medicine Attendance regulation: attendance is mandatory

Teaching arrangement and method of instruction: Grading scale: Bedside teaching is the main component of teaching in rounds and includes: Honors/High Pass/ Pass/Fail 1. – Rounding with medical staff and guided rounds -Students will join staff for visits and will learn from a senior physician about the approach to patients’ medical problems. During the visit students will perform partial physical examination while emphasizing pathological findings. Students will take part in discussions about treatment and diagnostic program for each patient, while working with multidiscipline staff.

-Guided rounds are for students only. The purpose is to have an in-depth discussion about the medical approach to the patient and his or her problems. The rounds are done by the dept. doctors as well as doctors from other disciplines: hematology, endocrinology, infectious disease, pulmonology, gastroenterology, cardiology, and rheumatology.

Usually the rounds are with patients who were received by the students: the student presents the patient to the other students and the tutor, performs a full physical examination, interprets the results of the patient’s tests, defines the patient’s problems, discuss the differential diagnosis and suggests a program for diagnosis and treatment.

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Coordinators: 2.- Receiving patients for learning purpose- Dr. Genia Brandstaetter Includes taking a history, collecting data from the patient's file, full physical examination, interpreting relevant tests, defining a patient's problems using SOAP (subjective, objective , assessment , plan) method. These admissions form the Contact details basis of learning clinical reasoning along with learning the different medical Office No.: problems a student should be familiar with. The admissions are reviewed by the E-mail: dept. doctors and are checked by a senior doctor/head of the dept. [email protected] Frontal teaching-short seminars (1 hour) about approach to patients with the most common problems in internal medicine- while emphasizing the clinical Office hours: aspect of the diseases: symptoms, physical findings, differential diagnosis etc. (see a list of subjects). TBA

Course tasks: attendance mandatory Course evaluation: 1. 12 admissions to be submitted to supervisor Student survey and debriefing 2..Drug of the day-in order to get to know better the common medications used in meeting at the completion of the internal medicine, the student should prepare a short lecture about each clerkship medication including activity mechanism, indications, contraindications, side effects : Confirmation:  Nitrates, digoxin The course has been  Beta blocks approved by the faculty teaching  Calcium blocks committee for 2019-20  Antiarrthymic medications  Hyperstension treatment-ACE inhibitors &After load Reduction  Beta-lactames: penicillins, cephalosporins Last update: August 2019  Aminoglycosides (including monitoring levels of medication) tetracyclines and chloramphenicol  Medications for Tuberculosis  Anti-thrombin, anti 10a, heparin and Coumadin  Insulin and Oral hypoglycemic drugs, GLP-1 agonists and DPP4 – inhibitors  NSAIDS and steroids

3. Accompanying the patient to tests and diagnostic procedures. Eg: endoscopy, echocardiography, heart catheterization, bronchoscopy, different punctures (abdominal, pleural), bone marrow biopsy

4. Actions the student should perform during the round: • Taking blood tests • Inserting IVs • Taking vital signs: blood pressure and pulse manually, number of breaths per minute • Perform and interpret ECGs • Taking urine samples and examine them under a microscope

5. Once a week every student should do a shift until 23:00 with the staff doctor and accompany him or her. Student Requirements: 1. Mandatory attendance for all seminars and rounds 2. Satisfactory completion of a mini-CEX form 3. Submission of completed Log Book 4. Completion of 10 NEJM cases: http://www.nejm.org/multimedia/interactive-medical-case 5. Completion and mandatory submission of 12 admissions 6. Completion and mandatory submission of Checklist (Moodle) 7. One mandatory seminar presentation 125 2 8. One mandatory Journal Club presentation Ben-Gurion University of the Negev Medical school for International Health

Assessment:

Evaluation according to 2 criteria: 1 Department evaluation – the department where the student worked will evaluate the student’s clinical abilities and knowledge during the round: 50% of final grade 2 Written test: NMBE shelf test 50% of final grade

Course Structure: Daily Activity: 7.30-8.30 taking bloods 8.30-9.30 morning meeting (including academic activity in the dept.) 9.30-10.30 Medication of the day 10.30-12.30 morning visit (guided or xxx) 13.30-14.30 seminar (twice-three times a week) 14.30-16.300 “kabalat” a patient

Main Subjects: • Cardiovascular diseases: • Approach a patient with hypertension • Approach a patient with chest pain • Approach a patient with acute coronary event • Approach a patient with a heart failure • Approach a patient with an Atrial Fibrillation • Approach a patient with arrhythmia • Viral Diseases • Approach a patient with a fever • Approach a patient with Sepsis • Approach a patient with TB • Approach a patient with HIV • Approach a patient with SBE • Approach a patient with urinary infection • Respiratory diseases • Approach a patient with pneumonia • Approach a patient with COPD • Approach a patient with Asthma • Approach a patient with pulmonary embolism • Approach a patient with shortness of breath • Hematological diseases • Approach to Thrombophilia • Approach to Anemia • Lymphoma • Leukemia • Nephrology diseases • Approach to acute lungs failure • Approach to disorders of Sodium balance • Approach to disorders of Potassium balance • Fluids and electrolytes program for an internal patient • disorders of Acid-Base balance • Endocrinology and Metabolic disease • Approach a patient with Dislypidemia • Approach a patient with thyroid disorders • Approach a patient with hyperglycemia and diabetes • Approach a patient with hypoglycemia • Gastroenterology Diseases • Approach to chronic Gastroenterology Diseases • Liver Enzyme disorder

Required time for self-study: Approx. 3 hours a day for completing tasks and reading relevant material

Reading List: All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

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Name of the course: Neurology Clerkship Number of course: 481-8-3098

BGU Credits: 4.5 Course Description:

ECTS credits: Objectives of the course: The goal of the Neurology Clerkship is to make the students familiar with Academic year: 2019-20 neurological conditions and approach to neurological problem-solving.

Learning outcomes of the course: Semester: 2 On successful completion of the course, the student should be able to: 1. To acquire skills in neurological examination, localization and systematic Hours of instruction: 80 neurological evaluation. 2. To be familiar with common neurological symptoms and signs. Location of instruction: 3. To be exposed to different common neurological conditions. Faculty of Health Sciences classroom, 4. To be able to construct a neurological differential diagnosis based on hospital wards localization of the lesion, disease course and anamnestic/demographic characteristics. Language of instruction: English 5. To understand the importance of the different imaging exams and electrophysiological tests in diagnosis. 6. To be familiar with the management and therapy of common neurological Cycle: 1st diseases. 7. To be familiar with common neurological emergencies. Position: Mandatory clerkship Attendance regulation:

Field of Education: MD Mandatory

Responsible department: MSIH Teaching arrangement and method of instruction: Bedside rounds, practice sessions-neuro exam, self-learning, case-based seminars, participation in usual ward activities-imaging meetings, General prerequisites: neurophysiology, outpatient clinics, participation in evening duties Successful completion of all basic science courses and systems with Assessment: special emphasis on neurology,  Submission of a complete patient admission form neuroanatomy and neurophysiology  Performance during the clerkship

Grading scale: Work and assignments: Honors /High Pass/Pass/Fail Attendance/lecture preparation Self-review of neuroanatomy/neurophysiology

Time required for individual work: Approximately 3 hours/day for completing tasks and reading relevant material.

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Coordinator: Clerkship Content\ schedule and outlines: Dr. Yacov Ezra (Soroka) Lectures/seminars:

Dr. Ron Milo (Barzilai) 1. The neurological examination Dr. Armon Carmon (Assaf Harofe) 2. Multiple sclerosis 3. Headache Contact details : 4. Neuro-radiology Office phone : 5. Neuro-ophthalmology 6. Neuromuscular diseases including ALS Email: [email protected] 7. Stroke [email protected] 8. Movement disorders [email protected] 9. Epilepsy 10. Infections of the nervous system 11. Dementia Office hours: 12. Neurological Emergencies

Course evaluation: Required reading: Online student survey and debriefing Aminoff MJ, Greenberg DA, Simon RP eds,. Clinical Neurology, 6th edition McGraw at the completion of the clerkship Hill Lange

Confirmation: 2019-20

Last update: January 2019

* All learning material will be available to the students on the course's website 128 (Moodle)/ library/ 2 electronic documents available to BGU students. Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Obstetrics and Gynecology Clerkship Number of course: 481-8-3079

BGU Credits: 9 Course Description: Aims of the course: ECTS credits: To gain both theoretical and practical knowledge of Obstetrics and Gynecology as well as getting a hands-on experience of what clinical work is all about.

Academic year: 2019-20 Objectives of the course: * History- obtain and present obstetrical and gynecological history Semester: 2 * Physical examination- the student will perform a physical examination with emphasis on OB GYN (Leopold maneuvers, physiological changes during Hours of instruction: 240 pregnancy). * Fetal heart rate monitor- interpretation of the FHR and the uterine activity. * Sonographic assessment- observation of US examination and interpretation of Location of instruction: the results Maternity wards at: *Procedures- observation of obstetrical procedures (cesarean sections, balloon Soroka Medical Center induction, amniocentesis) and gynecological procedures (vaginal and abdominal operations, colposcopy, PAP). * Patient care- OB including patients with PET, PROM, GDM, preterm Language of instruction: English labor/PPROM. GYN including uterine bleeding, amenorrhea, infection and uro- vaginal complaints.

Cycle: 1st Learning outcomes of the course: On successful completion of the course, the student should be able to: Position: Mandatory clerkship 1. Conduct a gynecological and obstetric interview and understand the concepts of physical examination Field of Education: MD 2. Understand and approach the management of a normal birth 3. Identify normal pathologies of pregnancy and issues relating to infertility 4. Understand and identify pathologies in Gynecology and Gynecologic Responsible department: MSIH oncology 5. Understand the basic concepts of infertility treatments General prerequisites: Successful completion of all basic Attendance regulation: science courses and systems. Mandatory for all departmental activities throughout the day. Teaching arrangement and method of instruction: Grading scale: The clerkship begins with one week of introductory lectures followed by four Honors/High Pass/Pass/Fail weeks of “hands on” clinical work in the form of clinical case discussions and seminars that students will prepare. The introductory week aims to teach the clinical and pathological aspects of ObGyn, and is naturally closely linked and based on the knowledge acquired in the reproductive course in second year. Students are required to complete a pre-test based on this material by the end of the first week.

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Coordinator: Assessment:

Dr. Roy Kessous NBME shelf test : 50% Contact details: Department clinical evaluation: 25% OSCE/Oral exam: 25% Office ph one: Email: Work and assignments: [email protected] The clinical requirements include knowledge of how to conduct a gynecological and obstetric interview and physical exam, identification of normal pathologies of Office hours:

Individual meetings can be arranged obstetrics and gynecology and issues relating to infertility. Each student must via email. actively participate in ten deliveries plus two Caesarian Sections, one laparoscopic surgery, and one pelvic floor surgery in order to complete all the requirements of Course evaluation: the course. Each student is also required to conduct a seminar. Online student survey and end of clerkship debriefing. Time required for individual work: In addition to attendance in class, the students are expected to do their Confirmation: 2019-20 assignment and individual work:

Last update: Individual work- divided into text book reading- 15 hours Seminar preparation - 10 hours. October 2019

Required reading: Obstetrics and Gynecology by Beckman, Ling, Barzansky, Bates, Herbert, Laube and Smith, 6th Ed. 2009

Additional literature:  Obstetrics and Gynecology – Current Diagnosis and Treatment, Alan H. Decherney et al, McGraw Hill LANGE, 11th Ed.

 Danforth's Obstetrics and Gynecology (Hardcover - April 1, 2008) 9th ed., Scott,Disaia, Hammond, Spellacy, by Lippincott.

 Williams Obstetrics, Pritchard, Macdonald, Gant, 23rd ed. By Appleton- Century Crofts.

 Gynecology, Novak, Jones and Jones, 14th ed. By Williams and Wilkins.

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

130 2 Ben-Gurion University of the Negev Medical School for International Health Name of the course: Pediatric Clerkship Number of course: 481-8-3071

BGU Credits: 11 Course Description: Aims of the course: ECTS credits: The purpose of the pediatric rotation is to provide the student with an appropriate approach, clinical skills, and knowledge in pediatrics.

Academic year: 2019-20 Objectives of the course:  Students will demonstrate a strong foundation in Pediatric knowledge Semester: 1  Students will develop skills in patient care including history taking, physical examination of the infant, child, and adolescent and adapting appropriately to the age, and clinical problem solving Hours of instruction: 280  Students will demonstrate interpersonal communication skills that facilitate effective and empathic relationships Location of instruction:  Students will develop professional qualities such as compassion, empathy and respect to patients, families and health care team Soroka University Medical Center  Students will demonstrate a commitment to developing personal and professional excellence including self-directed learning, reflective practice, the Language of instruction: English critical evaluation of the performance of peers and self, and promotion of collaborative learning  Students will demonstrate awareness and responsiveness to the system of Cycle: 1st health care and the ability to effectively draw on system resources to provide care that is of optimal value Position: Mandatory clerkship Learning outcomes of the course: On successful completion of the course students should be able to: Field of Education: MD 1. Elicit a full history, including a family history, social history 2. Perform a thorough physical examination Responsible department: MSIH 3. Perform an accurate urinalysis and stool sample examination 4. Interpret basic laboratory results and imaging

General prerequisites: Teaching arrangement and method of instruction: Successful completion of all basic  Bedside teaching/clinics/seminars/reports science courses and systems.  Students will have supervised rounds, will see and present patients and will be exposed to various common children's ailments.

Grading scale: Work and assignments: Honors/High Pass/Pass/Fail 10 submitted admissions 5 on-calls: 3 ER; 1 neonatal; 1 weekend 1-2 seminar presentations on the Pediatric wards 1-2 seminar presentations on the Neonatology wards

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Coordinator: Assessment: Dr. Orna Staretz-Haham NBME shelf test: 35% OSCE/Oral exam: 15% Departmental evaluation: 50% Contact details: Office phone: 054-5713191 Email: [email protected] Attendance regulation: Office hours: Mandatory for the duration of the clerkship TBA at first session

Course evaluation: Online student survey and debriefing Time required for individual work: at completion of clerkship In addition to attendance in class and on the wards, the students are expected to read around their patients, prepare their presentations, admissions and reports. Confirmation: The syllabus was confirmed by the faculty academic advisory committee to be valid on 2019-20 Module Content\ schedule and outlines:  Introduction Last update: September 2019  Assignment to general Pediatric ward (~ 4 weeks)  Assignment to an ambulatory clinic (1 week)  Neonatology ward (4 days)  Healthy Baby Clinic (1 day/week)  Cross-cultural Medicine Workshop (2 days)

Required reading: Textbook: Nelson: Textbook of Pediatrics 20th Edition Students are expected to read updated reviews and relevant book chapters.

132 2 Ben-Gurion University of the Negev Medical School for International Health Course Content\ schedule and outlines: Clerkship Content  Seminars Morning Report 1. Recurrent seizures Daily: Students who were on-call the previous night present 2. Limp/refusal to walk one case (3-4 times over the duration of the clerkship) 3. Diabetes 4. Short stature 5. Precocious puberty On-calls 6. Cyanosis Total of 5 on-calls during the clerkship including: 7. Abdominal pain - ER x 3 8. Hematuria - Neonatololgy x 1 9. Shock - Weekend on-call x 1 10. FTT 11. Edema 12. Hypotonia 13. Anaemia

 Patient teaching rounds 1. Osteomyelitis and Meningitis 2. Pneumonia 3. Upper air way 4. Neurodevelopmental disorders 5. PICU

 Lectures 1. Inborn Errors of Metabolism 2. Abuse case 3. Psychiatry case 4. Introduction to pediatric antibiotics 5. Fluids and electrolytes 6. Rashes 7. Communication with adolescents 8. Eating disorders

 Physical examinations 1. Pediatric neurological examination 2. Pediatric cardiology examination 3. Pediatric respiratory system examination 4. Pediatric ear examination

 Ambulatory visits 1. Bedouin community 2. A community clinic (טיפת חלב /Healthy baby clinic (Tipat halav .3 4. Outpatients clinic in Soroka Medical Center

(פגיה/ 4 days in Premature baby department (Pagia

 Rounds every morning in the Pediatrics wards

 Pediatrics Radiology

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Name of the course: Psychiatry Clerkship Number of course: 481-8-3078

BGU Credits: 6 Course Description: Aims of the course: ECTS credits: This clerkship complements the preclinical Neuro/Psychiatry courses and presents the opportunity for students to experience as much as possible of what they know in theory, and to apply that knowledge to clinical situations with Academic year: 2019-20 patients. Since the interview serves as the clinical examination in Psychiatry, this is an opportunity to hone interpersonal skills. The primary aim of the faculty is to Semester: 2 work on the clinical aspects and students will have to devote time to independently studying theoretical material, in order to gain from clinical tutoring in the various settings. Hours of instruction: 160

Objectives of the course: Location of instruction: Faculty of To impart basic clinical and research knowledge and skills in the field of clinical Health Sciences classroom psychiatry.

Language of instruction: English Learning outcomes of the course: On successful completion of the course, the student should be able to: Cycle: 1st 1. Establish good, open communication with patients based on trust, empathy and respect. Position: Mandatory clerkship 2. Establish effective and thorough interview skills 3. Diagnose major and prevalent types of psychopathology. 4. Formulate short and long-term treatment plans incorporating Field of Education: MD psychopharmacology, psychotherapeutic interventions, rehabilitation, psycho-education, and family-oriented interventions. Responsible department: MSIH Attendance regulation: Full attendance and active participation are expected daily throughout the General prerequisites: clerkship. All basic science courses and systems

Teaching arrangement and method of instruction: Grading scale: “Bedside” interviews/role-playing/self-learning Honors/High Pass/Pass/Fail Observation and participation in the ongoing activities of inpatient, outpatient, and day program units.

Assessment: 40% NBME Test 30% OSCE 30% Department clinical evaluation

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Lecturer: Dr. M. Matar Work and assignments: Contact details:  Students are expected to interview patients  Read the required material  Detailed patient write-up (to be handed to tutors and revised together Office phone: 08-6401602 with tutors; final version to be handed in – hard copy or email – to Dr Email: [email protected] Matar; deadline = 3 days prior to OSCE)  Submit the Psychiatric Checklist at the completion of the clerkship Office hours: TBA at first session Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: Course evaluation: Online student survey and debriefing An additional 2-3 hours of reading and preparation is required per day. at the completion of the clerkship

Required reading: Confirmation: 2019-20 Kaplan and Saddock, Synopsis of Psychiatry, Behavioral Sciences/Clinical Psychiatry

Last update: Additional literature: January 2019 Current research papers and reviews on such topics as schizophrenia, bipolar disorder, depression, eating disorders, post-traumatic stress disorder, anxiety disorders, personality disorders, and updated guidelines regarding psychopharmacology

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Clerkship Content\ schedule and outlines: Design: a. Small groups will be allocated to various wards and outpatient services in the affiliated to the faculty in Beersheva. The day is divided into ward activities in the morning hours and tutoring on the ward after lunch, and whole-class activities on some afternoons. We aim to expose the student to as broad a variety of settings and patients as is feasible (ER, clinics and wards, consultation-liaison to general hospital wards in Soroka, and both adult and adolescent populations). b. The class activities are clinically oriented, presented by senior teaching staff proficient in English and include clinical discussions, work with standardized patients, role-playing and training in practical tools, such as Crisis Intervention. c. In the evenings, students attend the ER’s in pairs and/or join English-speaking physicians on duty on the wards. d. The course is compact, demanding and rather intense. It aims to minimize passive learning and to maximize ward/clinic experiences and to focus on pro-active experiential learning on practical issues. It therefore relies very heavily on pre-learning and self-learning by the students.

The course culminates in an OSCE exam and a USMLE Step2-compatible shelf test. The ward tutors assess the practical skills and clinical attitude/thinking of their students. Each component must be individually passed and the final grade is a composite of all these components (30%, 40% and 30%, respectively). Components on which the student has not attained a passing grade must be redone. Recurrent failure requires the course to be retaken at a later date. (For practical purposes, the OSCE cannot be retaken and the retake is in the form of an oral exam before two senior faculty members, involving an interview with a real patient and relevant discussion thereafter).

Lectures: 1. Review of psychiatric examination, symptoms and classification 2. Review of psychopharmacology 3. Presenting and write-ups 4. Interview practice 5. Suicide risk assessment

136 3 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Surgery Number of course: 481-8-3074

BGU Credits: 9 Course Description: Aims of the course: ECTS credits: The purpose of this six-week clerkship is to provide the student with the appropriate approach, a thorough knowledge and clinical skills in surgery.

Academic year: 2019-20 Objectives of the course: Students will be exposed to the daily activities of surgical wards and operating Semester: 2 rooms and will also acquire some essential knowledge in Ambulatory Surgery (outpatient clinics and morning ER “light” pathology), Proctology, Breast and Hours of instruction: 240 Trauma Surgery in the form of rotations in the respective services and units. They will also choose between a wide range of elective subjects.

Location of instruction: The goal of the clerkship is to develop the students' clinical thinking. While Faculty of Health Sciences classroom progressing in the clerkship, the student will gain tools to enable him/her to process the information relevant to the patient's condition, distinguish the Language of instruction: English important information, define the patient's problems to arrive at a differential diagnosis, discuss possible avenues for further diagnosis, and develop a treatment program. Cycle: 1st Learning outcomes of the course: On successful completion of the course, the Position: Mandatory clerkship student should be able to: 1. Process an admission for a surgical patient using POR Field of Education: MD 2. Present the patient both verbally and in writing 3. Discuss a problem in , including differential diagnosis and basic knowledge in trauma, emergency surgery and elective surgical Responsible department: MSIH conditions

General prerequisites: Attendance regulation: Successful completion of all basic Mandatory for all departmental activities and seminars. science courses and systems

Teaching arrangement and method of instruction: Grading scale: Lectures, Bedside Teaching & Seminars Honors/High Pass/Pass/Fail Teaching rounds: Tutor rounds, walking rounds, evening rounds, radiology On-call, evenings Ambulatory outpatient clinics An introduction to Pediatric and Plastic surgery in the form of lectures and seminars will be provided at the end of the clerkship.

137 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Dr. Ilia Pinsk Assessment: Contact details: NBME Shelf Test: 50% Department clinical evaluation including student requirements below: 50%

Office phone: Student requirements: Email: [email protected]  Submit 10 admission forms by conclusion of clerkship Office hours:  Complete 5 on-calls by conclusion of clerkship TBA at the first session  Blood draw each morning, in pairs  Submit 10 patient stickers by conclusion of clerkship Course evaluation:  Participation in at least 15 surgeries including submission of patient Online student survey and debriefing stickers and title of the surgery at the completion of the clerkship  Seminars will be prepared before the Pediatric Surgery Day and given by the students on the same day under the supervision of a teacher. Confirmation: 2019-20 Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work: Approximately 3 hours per day for completing tasks and reading relevant material. Last update: October 2019 Required reading: 1. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice C. M. Townsend et al. 19th Ed. 2012 2. Current Surgical Diagnosis and Treatment. Lange, 13th Ed. 2012 3. TEAM – Trauma Evaluation and Management

Prerequisites 1. Fluids, Electrolytes, Acid-Base balance, Shock 2. Nutrition in the Surgical Patient 3. Hemostasis, Coagulation & Transfusion 4. Wound Healing 5. Embryology & Anatomy

138 2 Ben-Gurion University of the Negev Medical School for International Health

I. Diseases per Organs

1. Thyroid Nodules, Multinodular Goiter, Cancer

2. Parathyroid Adenoma, Hyperplasia, Hyperparthyroidism 3. Breast Abscess, Fibroticystic Disease, Benign & Malignant Tumors 4. Adrenal Adenoma, Pheochromocytoma 5. Esophagus Hiatal Hernia, G.E.R.D., Esophagitis, Mallory-Weiss, Cancer 6. Stomach & Duodenum Ulcer disease, Morbid Obesity, Gastric Cancer 7. Small Intestine Small Bowel Obstruction 8. Inflammatory Bowel Disease Crohn’s Disease, Ulcerative Colitis 9. Large Bowel Diverticular Dis., Bleeding, Volvulus, Polyp, Colorectal Cancer 10. Appendix Appendicitis 11. Anus Fissure, Hemorrhoids, Perianal Abscess & Fistulas 12. Abdominal Hernias Inguinal, Umbilical, Femoral, Incisional 13. Liver Portal Hypertension, Echinoccocal Cysts, Iry & IIry Cancer 14. Biliary Tract Lithiasis, Cholecystitis, Biliary Obstruction, Surgical Jaundice 15. Pancreas Pancreatitis, Cysts, Cancer 16. Peritoneum Peritonitis, Intra-abdominal Abscess, Cancer 17. Surgical Pre-& Post operative Care 18. Surgical Complications Fever, Wound Infection, Bleeding, Postoperative Complications: Cardiac, Pulmonary, Neurological

II. Problem-Based Surgery 1. Abdominal Pain 11. Bowel habit change 2. Abdominal Mass 12. Shock 3. Inguinal Mass 13. Intestinal obstructions 4. Cervical Mass 14. Adrenal mass 5. Breast Mass 15. Ascites 6. Dysphagia 16. The catabolic state 7. Heart-burn 17. Imaging in surgery 8. Jaundice 9. Gastro-intestinal Bleeding 10. Anal Pain

III. Specific Topics 1. Organ Transplantation Waiting Lists, Donors, Indications, Immunosuppression, Complications 2. Trauma Mechanism, Evaluation & Priorities, Resuscitation, Imaging, Surgery, Intensive Care, Specific Topics (Head, Orthopedics, Vascular, Pediatric) 3. Pediatric Surgery Inguinal Pathology, GI Tract, Trauma 4. Plastic Surgery Burns, Reconstruction, Hand, Microsurgery

139 3 Fourth Year Elec�ves/Sub-internship, GHM Clerkship and Selec�ves

140 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: 4th Year Elective Number of course: 481-8-4001/2/3

BGU Credits: 6 Course Description: The elective provides a general overview to the nature of the selected field of medicine and its practice. It consists of a four-week rotation on a designated ECTS credits: service contained within the department of choice. Depending on the chosen elective the student may be exposed to operating room procedures, emergency room diagnosis and treatment, care and evaluation of in-house patients and the Academic year: 2019-20 varying didactic programs of the department. It is designed for students interested in gaining additional knowledge about a particular field of medicine. The student will be supervised at all times by housestaff or faculty based on the Semester: 1 hospital specific guidelines.

Objectives of the course: Hours of instruction: 160 1. To gain a general understanding of the various different

Location of instruction: types of practices and procedures.

Israel 2. To understand the principles behind the evaluation and

treatment of patients. Language of instruction: English 3. To gain exposure and experience in different hospitals'

patterns of care . Cycle: 1st 4. To demonstrate the ability to present a cogent focused and

comprehensive case presentation, history, and discussion. Position: Mandatory elective Student responsibilities:

Field of Education: MD 1. The student is an integral member of the team and responsible for rounding on patients and providing clinical care on the ward/Emergency Room and/or operating theatre. Responsible department: MSIH 2. The student is required to spend one night a week on-call and spend one weekend day/night during the rotation. While on-call, General prerequisites: the students are expected to assist the junior resident on-call in the evaluation and management of acute cases. Completion of 3rd year 3. The student is also responsible for preparing and giving a requirements USMLE case presentation to his/her preceptor twice during the 4 week Step 1 rotation, as well as actively participating in weekly student conferences and weekly team conferences.

4. Student may present a seminar. Grading scale: Honors/High Pass/ Pass/Fail

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Elective Coordinator: Prof. Didactic Program Shimon Glick Contact details : Each student is assigned a preceptor, who is a member of the full time faculty. Office phone: 08-6479908 The student will meet with his/her preceptor twice during the rotation and Email: [email protected] present a case followed by a discu ssion with their preceptor. The didactic program includes all depart ment daily and weekly conferences as well as weekly Grand Rounds . Students may be asked to participate in researching and answering varying clinical questions tailored to their abilities and knowledge. Students will also be required to attend skills sessions during the rotation. Course evaluation: Student evaluation submitted at completion of elective. Method of Evaluation

Confirmation: • The students are evaluated by the chief resident assigned to The syllabus was confirmed by their service and also by their preceptor. Students will be evaluated on the faculty academic advisory our approved written evaluation which evaluates students based on the committee to be valid on 10 June ACGME milestones and core competencies.

2019. • They are evaluated based on their performance during the rotation, including knowledge base, ability to work as a team member and interactions with patients and peers. Last update: June 2019 • In addition, the student is required to submit an evaluation of the rotation itself prior to leaving the evaluation.

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Name of the course: 4th Year Research Elective Number of course: 481-8-4060

BGU Credits: 6 Course Description: The elective provides a general overview of the performance of research in a selected field. The elective consists of a 4-week rotation on under ECTS credits: direct observation by the research mentor at an approved location, preferably academic Medical Center. The student will be exposed to research methods and procedures including but not limited to project Academic year: 2019-20 selection, creation of a research protocol, ethics of research, patient privacy, and data collection / analysis. The project can be laboratory, epidemiological or clinical in scope. Multiple month research electives can Semester: 1 month be performed with approval of the associate director or director of the medical school. Hours of instruction: 160 Objectives of the course:

Location of instruction: 1. To gain the general understanding of methods practices and Protocols US/Canada/Israel of medical research

2. To gain an understanding of the background information and Language of instruction: English knowledge in the field of research . 3. To properly construct a hypothesis or theory for further research Cycle: 1st-4th 4. Understand how to monitor the research project, collect data, and perform proper analysis. Position: Elective course Student responsibilities:

Field of Education: MD The student is expected to participate as an integral member of the research team.

Responsible department: MSIH This includes but is not limited to

 involvement in daily activities with the research team / laboratory. General prerequisites: None  presence at all collaborative conferences and research team meetings.

Grading scale: Pass/Fail  cooperation with the research team for hopeful publication of research.

 presentation at Regional meetings.

 Students are required to complete a research paper based on their subject of research during this elective. The research paper need not include original research, although that is encouraged. A summary of current medical knowledge and proper presentation of the research project goals can satisfy this requirement.

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Elective Coordinator: Didactic Program

Prior to starting the research elective, the students must identify Contact details: Prof. Taragin a preceptor / mentor scientist. The student will meet with his/her Office phone: 08-6479907 preceptor weekly (at least) during the elective to review research results, processes, and materials up to that point to discuss as well Email: [email protected] as to plan immediate directional changes if identified. Students are encouraged to complete a course in research ethics and code of Course evaluation: conduct (such as the Helsinki course). Student evaluation submitted at completion of elective. Method of Evaluation Confirmation: The syllabus was confirmed by  The students are evaluated by their preceptor. the faculty academic advisory  Students are evaluated based on their performance during committee to be valid on 2019- the elective, including knowledge base, project development 20 and implementation and ability to work as a team member.  In addition, the student is required to submit an evaluation of the elective itself prior to leaving the evaluation. Last update: March 2019  Thesis paper

144 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: 4th Year Sub-internship Number of course: 481-8-4004

BGU Credits: 6 Course Description: The Sub-internship experience is the culmination of medical training ECTS credits: where the student can translate their various years of training into clinical practice. The level of student responsibility is greater than for the elective and includes on-calls with the team. More time is spent with the Academic year: 2019-20 team/attending which results in more intense learning and teaching. The student functions as a supervised intern and is required to "carry" at least 0.5 of a clinical interns' patient load. Semester: 1

Objectives of the course: Hours of instruction: 160

Generally the role of a medical student during a sub-I is to function as an Location of instruction: intern and work effectively with the hospital teams (including nursing, US/Canada/Israel ancillary services, referral services, social work…) in managing patient care.

Language of instruction: English Student responsibilities: A student who participates in this Sub-Internship will be expected to: Cycle: 4th year  Be included in the Intern’s call schedule. The clinical care responsibilities include weekends and holidays during the block Position: 1st semester that are identical to the intern schedule. Currently this does not include any independent overnight calls and is compliant with Field of Education: MD ACGME requirements.  Work closely with the supervising Resident and Attending Physician to care for assigned patients, including appropriate Responsible department: MSIH documentation, order entry and consultation.  Attend and participate in daily work rounds as well as attending General prerequisites: rounds at the assigned teaching hospital.  Perform appropriate procedures under the supervision of - Completion of 3rd year Residents or Attending Physicians. requirements  Be aware of assigned teaching sites’ patient safety protocols, - USMLE Step 1 including appropriate escalation procedures and activation of Codes/Rapid Response teams. Grading scale: Honors/High Pass/  Attend assigned sites daily didactics, including weekly Conference Pass/Fail and Department Grand Rounds.

145 Ben-Gurion University of the Negev Medical School for International Health

Sub-intership Coordinator: Didactic Program Prof. Shimon Glick The visiting student must be present at daily Morning, and Attending Rounds as well as Noon Conference at each of their assigned Contact details : institutions. Students will also attend weekly Conference and the Department of Medicine Grand Rounds. Office phone: 08-6479909

Email: [email protected] Method of Evaluation

Students will be evaluated by the Chief Residents and select faculty Course evaluation: members (preceptors), with whom they will interact during the sub- Student evaluation submitted at internship. Students will be evaluated on our approved 360 degree completion of the Sub-I. written evaluation which evaluates students based on the ACGME milestones and core competencies. Confirmation: The syllabus was confirmed by At the completion of the rotation a departmental evaluation in the the faculty academic advisory committee to be valid on June format of the standardized letter of recommendation will be 2019 provided to ERAS at student request. Additionally, students are welcome to ask for letters of recommendation from faculty with

Last update: June 2019 whom they have worked during the rotation.

146 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Global Health and Medicine (GHM) Clerkship Number of course: 481-8-4005

BGU Credits: 12 Course Description: The Global Health and Medicine (GHM) Clerkship is the culmination of a unique program at MSIH in which students acquire practical knowledge and ECTS credits: exposure to the core Global Health competencies, namely: 1. Cross-cultural health and medicine Academic year: 4th Year 2. Global burden of disease 3. Geographic medicine 4. Global factors and organizations Semester: 2 5. Vulnerable populations 6. Impact of global health on primary care

Hours of instruction: 8 weeks The GHM Clerkship is an eight week capstone clinical experience that takes place in a developing country or in a specifically approved clinical setting Location of instruction: related to Global Health. The Clerkship is scheduled from mid-January to mid- Global Health sites March.

Aims of the course: Language of instruction: English The goal of the GHM Clerkship is to learn to apply the GH competencies in the clinical setting, and to experience how different cultures and medical teams Cycle: 1st promote health and provide good medical care in the face of severely limited resources. In so far as is possible, MSIH students should be integrated with the training programs of local medical students. Position: Objectives of the course: 1. To learn about the country, its people and their culture: Field of Education: MD 2. To learn about important public health issues of the country

Responsible department: MSIH Teaching arrangement and method of instruction: MSIH students will do clinical rotations in the teaching hospital, elective weeks and community medicine rotation General prerequisites: None Attendance regulation: Grading scale: Assessment: Honors/High Pass/Pass/Fail Evaluation by Site supervision 2 case report Writing blog once a week

Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work:

147 Ben-Gurion University of the Negev Medical School for International Health

Course Coordinator:

Dr. Noah Liel Module Content\ schedule and outlines: Example Schedule for Global Health and Medicine Clerkship 2020 Contact details : Location: India

Office phone : Week Student 1 Student 2 Student 3

Email: Jan 14-18 Ophthalmology General Medicine Anaesthesia [email protected] Jan 21-25 Ophthalmology General Medicine Anaesthesia Jan 28-Feb1 Ophthalmology General Medicine Anaesthesia Feb 4-8 Community Health Community Health Intensive Care Office hours: Feb 11-15 Neurosurgery Radiology Community Health Feb 18-22 Neurosurgery Radiology Dermatology Course evaluation: Feb 25- Mar 1 ENT Endocrine Radiology Debriefing at end of clerkship Mar 4-6 ENT Endocrine Radiology

Confirmation: Vehicle Doctor In- Activity Place The syllabus was confirmed by the Departure charge faculty academic advisory Time committee to be valid on 2019-20 9.00 am Urban Health Centre and Govt. Austin Town Maternity Hospital 8.30 am Eye Clinic and Visit to the GHK Mugalur Last update: (elderly day care centre)* December 2018 8.30 am Geriatric Clinic Kugur 8.45 am Maternal and Child Health Mugalur Clinic * 8.30 am Community Psychiatry Mugalur program * 9.00 am Urban Health Centre and Govt. Austin Town Maternity Hospital 8.30 am Eye Clinic and Visit to the GHK Mugalur (elderly day care centre) * 8.30 am Geriatric Clinic V Kalahalli 8.45 am NCD clinic Austin Town 8.30 am Community Psychiatry Mugalur program *

Resources: * All learning material will be available to the students on the module's website (high-learn)/ library/ electronic documents available to BGU students.

148 2 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Anesthesiology Number of course: 481-8-4096

BGU Credits: 2.5 Course Description: Aims of the course: ECTS credits : To teach topics in clinical Anesthesiology and Critical Care.

Academic year: 2019-2020 Objectives of the course: To provide basic knowledge and skills in clinical anesthesiology and critical care. Semester: 2 Learning outcomes of the course:

Hours of instruction : 2 weeks On successful completion of the course, the student should be able to: 1. Draw blood from a peripheral vein Location of instruction: 2. Measure blood gases Soroka University Medical Center 3. AL, CVP, SG 4. Insert a catheter Language of instruction: English 5. Insert a naso-gastro tube 6. Insert a urinary catheter Cycle: 1st 7. Intubate 8. Extubate Position: Elective course 9. Manual ventilation by mask

Field of Education: MD Attendance regulation: Mandatory

Responsible department: MSIH Teaching arrangement and method of instruction: Bedside teaching: In operation rooms (OR) and (ICU). General prerequisites: NA Students will have supervised rounds, will see and present patients and will be exposed to the various patients in anesthesiology and critical care setting. Grading scale: Frontal teaching: Daily frontal teaching Pass/Fail

Coordinator: Assessment: Dr. Tomer Kotek Tutor assessment of student's participation

Office phone: Work and assignments: Email: [email protected] Reading relevant material

Office hours: TBA Course Content\ schedule and outlines:

Course evaluation: Students will perform all the above mentioned procedures. Debriefing at completion of all Students will observe the following:  Epidural spinal and local blocks selectives.  Caesarian Section  Outdoor procedure Confirmation: September 2019-20 Required reading: Gurman G.: Anesthesiology: a practical manual for students, interns and new Last update: residents in Anesthesiology. 2005.

2019 *All learning material will be available to the students on the course's website .Moodle/ library/ electronic documents available to BGU student

149 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Dermatology Number of course: 481-8-4098

BGU Credits: 2.5 Course Description:

ECTS credits : Learning outcomes of the course: Academic year: 2019-20 On successful completion of the course, the student should be able to: 1. Diagnose common skin diseases and prescribe treatment Semester: 2 2. Diagnose severe skin diseases

Hours of instruction: 2 weeks 3. Diagnose signs of early-stage skin cancer

Location of instruction: Attendance regulation: Soroka University Medical Center Mandatory Language of instruction: English

Teaching arrangement and method of instruction: Cycle: 1st Frontal lectures and small groups, attendance at rounds and clinics

Position: Mandatory course Assessment: Field of Education: MD Tutor assessment of student's participation and clinical performance.

Responsible department: MSIH Work and assignments: General prerequisites: Reading of dermatologic oriented literature

Grading scale: Pass/Fail Time required for individual work:

Coordinator: Prof. A. Cohen In addition to attendance in class, the students are expected to do read the relevant material.

Contact details Course Content\ schedule and outlines: Office phone: During the rotation students will join the physicians at regular busy clinics Email: [email protected] Required reading:

Color Atlas and Synopsis of Clinical Dermatology. Fitzpatrick T, Office hours: Polano. MK, Suurmond D, Johnson RA. McGraw-Hill. TBA

Course evaluation: Debriefing at completion of all selectives.

Confirmation: 2019-20 * All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

Last update: November 2019

150 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Ear Nose and Throat (ENT) Selective Number of course: 481-8-4090

BGU Credits: 2.5 Course Description:

ECTS credits : Aims of the course: 1. Introduction to Otolaryngology Academic year : 2019-20 a. Otolaryngology – Head and Neck Exam b. Basic Anatomy/Physiology of Head/Neck region c. When to refer to an Otolaryngologist Semester: 2 2. Basic Audiology Hours of instruction : 2 weeks 3. Pathophysiology/treatment of common problems in Otolaryngology: Location of instruction: Soroka University Medical Center a. Acute/Chronic Otitis Media b. Hearing loss, tinnitus, vertigo c. Acute/Chronic Sinusitis Language of instruction: English d. Neck Masses, head and neck neoplasms e. Tonsils/adenoids (hypertrophy/infections) Cycle: 1st f. Otolaryngologic emergencies

Position: Elective course Objectives of the course: Exposure to the above Field of Education: MD

Responsible department: MSIH Attendance regulation: Mandatory participation in all activities mentioned below. General prerequisites: NA

Grading scale Teaching arrangement and method of instruction: Pass/Fail Students will participate in Departmental activities including outpatient clinics, surgery, Audiology and the Emergency Room. Coordinator: There may also be participation in oral surgery clinics and/or surgery. Dr. C. Peled

Assessment: Office phone: Participation Seminar Case presentation Email: [email protected]

Work and assignments: Office hours: TBA Students will be expected to present a seminar on a specific subject within the specialty of Otolaryngology, and each student will be Course evaluation: expected to participate in the comprehensive evaluation of at least Debriefing at completion of all one patient admitted to the department. selectives. There will be a pre- and post test as well, which will be discussed and evaluated in open forum after they are administered. Confirmation: 2019-20

Last update: January 2019

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

151 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Neurosurgery Number of course: 481-8-4018

BGU Credits: 2.5 Course Description:

ECTS credits: Learning outcomes of the course: On successful completion of the course, the student should be able to:

Academic year: 2019-20 1. Become familiar with common neurosurgical conditions and learn how to identify patients with these disorders; 2. Learn and practice clinical observation and examination of patients Semester: 2 with neurological disease 3. Recognize the signs and symptoms of the most common neurosurgical diseases and their initial evaluation and treatment. Hours of instruction: 2 weeks 4. Become familiar with common imaging modalities used neurosurgery, especially CT and MRI 5. Participate in the neurosurgical operations Location of instruction: 6. Learn the initial evaluation of a patient with head trauma Soroka University Medical Center

Attendance regulation: Language of instruction: English

1. Mandatory attendance and on call Cycle: 1st 2. Participation in all activities of the department, including patients rounds, surgeries departmental meetings, consultations, journal club and radiology conferences Position: Elective course Teaching arrangement and method of instruction: 1. Bedside teaching Field of Education: MD 2. Small group discussion 3. Departmental activities: seminars, lectures, meetings and Responsible department: MSIH conferences

General prerequisites: Assessment: Tutor evaluation of student's professional conduct and clinical performance Grading scale:

Pass/Fail Course Content\ schedule and outlines: Major topics: Coordinators: Dr. Tehila Kaisman-Elbaz  Examination and evaluation of neurosurgical patients  Basic neurosurgical trauma management Dr. Melamed  Surgical approach to Brain Tumors  Pediatrics neurosurgery  Normal and pathological brain Imaging Email: [email protected] Course evaluation: Required reading Debriefing at completion of all Toronto notes - Neurosurgery selectives. Neurology course lectures

Confirmation: 2019-20 * All learning material will be available to the students on the course's Last update: Sept. 2019 website (Moodle)/ library/ electronic documents available to BGU students.

152 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Oncology Number of course: 481-8-4083

BGU Credits: 2.5 Course Description:

ECTS credits: Aims of the course:

The purpose of the Oncology and Radiation Therapy elective is to provide senior Academic year: 2019-20 medical students with an understanding of the basic approach to the treatment of malignant disease by means of exposure to a wide range of cancer patients.

Semester: 2 Objectives of the course: 1) To give the students an opportunity to see how oncologists approach cancer patients Hours of instruction: 2 weeks 2) To demonstrate the basic principles of chemotherapy and biologic therapy and how they are used in the treatment of patients 3) To demonstrate the basic prinicples of radiotherapy and they are used in Location of instruction: the treatment of patients Soroka University Medical Center 4) To learn about some of the different types of cancer 5) To be exposed to ethical dillemas that are faced in cancer treatment

Language of instruction: English

Learning outcomes of the course: Cycle: 1st On successful completion of the course, the student should be able to: 1. Articulate the differences between palliative and curative cancer care Position: Elective course 2. Describe the expected side effects of a number of chemotherapy and biologic agents as well as radiotherapy 3. Understand the concept of adjuvant and neoadjuvant therapy and the Field of Education: MD types of patients who receive it.

Responsible department: MSIH Attendance regulation: Mandatory General prerequisites: Teaching arrangement and method of instruction:

Grading scale: Honors/Pass/Fail The elective will built on lectures that students have received in earlier years on chemotherapy, radiotherapy, and various malignancies. There will be sessions on radiation treatment planning and radiation safety. Most of the time will be spent with individual physicians seeing patients in the outpatient oncology clinic. Students will learn first hand through direct patient care how diseases are treated and how a doctor communicates with a patient with cancer. The experiences in the clinic will be reinforced by case conferences where students will present cases seen in the clinic. The cases presented will be the basis of learning about different cancers and their management.

153 Ben-Gurion University of the Negev Medical School for International Health

Lecturer: Assessment: Prof. David Geffen Attendance

Office phone : Work and assignments: 054-4699731 Students will take part in the department's new- patient conference, chief's ward Email: rounds and journal club conference. Most days there will be a case conference where students will report on patients [email protected] they observed with their assigned oncologist. Office hours: Each student will give a presentation on a type of cancer (to be assigned them)- Appointment via email including epidemiology, staging and treatment of that cancer.

Course evaluation: Time required for individual work: Debriefing at completion of all In addition to attendance at clinics and conferences, the students are expected to selectives. present patients seen in clinic with the oncologists as well as to give a presentation on a type of cancer (to be assigned). Confirmation: 2018-19

Last update: Required reading: November 2018 Relevant articles will be forwarded to the students during the rotation to help prepare the student presentations.

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Name of the course: Ophthalmology Selective Number of course: 481-8-4093

BGU Credits: 2.5 Course Description: Objectives of the course: ECTS credits: To provide the student with the knowledge and the ability to offer a diagnostic and therapeutic ocular health plan as part of the medical training. Academic year: 2019-20 Learning outcomes of the course: On successful completion of the course, the student should be able to: Semester: 2 1. Familiarization with ophthalmology equipment 2. Identify emergencies in ophthalmology Hours of instruction : 2 weeks 3. Recognize various eye diseases and their treatment

Attendance regulation: Mandatory Location of instruction: Soroka University Medical Center Teaching arrangement and method of instruction: Language of instruction: English An ophthalmoscope is required for each student and this can be obtained on loan from the department. The course starts with lectures in basic anatomy and physiology, acute and chronic visual Cycle: 1st loss and red eye. Students will then follow the Ophthalmologist on call to observe “bread and butter” ophthalmology cases in the Position: Elective course emergency room. Assessment: a roundtable - Oral exam Field of Education: MD Work and assignments: 1. Mandatory attendance Responsible department: MSIH 2. During the clinical week each student will stay with the on call resident until 21:00 Grading scale: Pass/Fail Time required for individual work: In addition to attendance in class, the students are expected to participate in the clinics and the operating room. Coordinator: Dr. R. Kormas Course Content\ schedule and outlines: # 1st day 8:00-16:00 – at the ophthalmology department- Ophthalmic equipment and eye examination. Email: [email protected] # Next 8 days: 08: 00-13: 00 students participate in various clinic work (including primary care Office hours: TBA clinics / general and clinics in the various sub-specialization) plus operating room. 13: 00-14: 00 Lunch break Course evaluation: Debriefing at completion of all 14: 00-16: 00 Seminar selectives. # 10th day - Roundtable - oral exam

Confirmation: 2019-20 Required reading: Last update: September 2019 Lectures and seminars delivered during the clinical course

155 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Orthopedics Selective Number of course: 481-8-4091

BGU Credits: 2.5 Course Description: A comprehensive approach to common orthopedic patients and injuries. ECTS credits : Aims of the course: Academic year : 2019-20 1. The students will understand how to approach and treat common orthopedic injuries and diseases

Semester: 2 2. The students will join all types of clinical activities during their clerkship

Hours of instruction : 2 weeks Learning outcomes of the course: On successful completion of the course, the student should be able to: Location of instruction: Soroka University Medical Center 1. Diagnose and set the treatment course for hip fractures 2. Diagnose and set treatment course for common fractures Language of instruction: English 3. Diagnose and set treatment course for common orthopedic emergencies

Cycle: 1st Attendance regulation: Attendance is mandatory Position: Elective course

Field of Education: MD Teaching arrangement and method of instruction: A preliminary discussion will take place on the first day of this Responsible department: MSIH rotation to cover goals and objectives. Every day a different tutor will guide the group through the various clinical and academic General prerequisites: NA activities in which students will be expected to play an active part.

Grading scale: Assessment: Attendance and participation Pass/Fail

Work and assignments: Lecturer: Each student will stay on call one night in the hospital and will join the residents Dr. Asaf Acker in the emergency room/ operating theatre.

Office phone: Course Content\ schedule and outlines: Email: TBA [email protected] Required reading: Office hours: TBA

Course evaluation: Debriefing at completion of all * All learning material will be available to the students on the course's website selectives. (Moodle)/ library/ electronic documents available to BGU students.

Confirmation: 2019-20

Last update: January 2019

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Thu Wed Tue Mon Sun Day/

18.5.2016 17.5.2016 16.5.2016 15.5.2016 time Dr. Dr. Benkovitch Elkarnawi Attending 8:15-9:00 9:00- Review of radiographs and discussion 10:00 Clinics / Approach 10:15- ER / OR Approach to: to: 11:00

Osteoarthritis Clinics / & Joint Sports Clinics / 11:15- OR / ER replacement injuries OR / ER 12:00 12:15- Physical Examination 13:00 13:15- Daily seminar (by the students) 14:00 14:15- Lunch break 15:00 15:15- On call - On call - On call - On call - 16:00 1-2 1-2 students 1-2 students 1-2 students students

Thu Wed Tue Mon Sun Day/

10.5.2016 9.5.2016 8.5.2016 time Dr. Dr. Kramer Bloom Dr. Ileeg Attending 8:15-9:00 9:00- Review of radiographs and discussion 10:00 Clinics / Approach Approach Approach Approach 10:15- ER / OR to: to: to: to: 11:00

Foot and 11:15- Tumors Spine Trauma Ankle 12:00 12:15- Physical Examination 13:00 13:15- Daily seminar (by the students) 14:00 14:15- Lunch break 15:00 15:15- On call - On call - On call - On call - On call - 16:00 1-2 1-2 1-2 1-2 1-2 students students students students students

157 2 Ben-Gurion University of the Negev Medical School for International Health

Thu Wed Tue Mon Sun Day/

5.5.2016 4.5.2016 3.5.2016 2.5.2016 time

Dr Weisel Dr. Abu-Kian Dr Ishano Attending 8:15-9:00 9:00- Review of radiographs and discussion 10:00 Clinics / Approach Approach Approach Approach 10:15- ER / OR to: to: to: to: 11:00

Pediatric Hip 11:15- ortopedics fractures Fractures Spine 12:00 12:15- Physical Examination 13:00 13:15- Daily seminar (by the students) 14:00 14:15- Lunch break 15:00 15:15- On call - On call - On call - On call - On call - 16:00 1-2 1-2 1-2 1-2 students students 1-2 students students students

158 3 Ben-Gurion University of the Negev Medical School for International Health

Name of the course: Plastic Surgery Selective Number of course: 481-8-4016

BGU Credits: 2.5 Course Description Aims of the course: To give the students very basic knowledge and skills in plastic and reconstructive ECTS credits: surgery.

Objectives of the course: Academic year: 2019-20 Participation in all activities of plastic surgery units, including ground rounds in the unit, outpatient clinic work, and operation theatres. Participation in the suturing workshop. Semester: 2

Learning outcomes of the course: Hours of instruction: 2 weeks On successful completion of the course, the student should be able to: 1. Assistance in the operating theatre Location of instruction: 2. Assistance in patients` treatment in the unit and outpatient clinic Soroka University Medical Center 3. Very basic skills in wounds suturing.

Language of instruction: English Attendance regulation: Mandatory Cycle: 1st

Teaching arrangement and method of instruction: Position: Elective course 1. Plastic surgery unit - grand round, ER, consultations 2. Outpatient clinics - general plastic surgery, burns, hand surgery, head and Field of Education: MD neck, and breast reconstruction clinic. 3. OR - small operations (surgical dermatology), day surgery - bigger operations, MOHS surgery, operations under general anesthesia. Responsible department: MSIH Students also participate in general departmental activities and will attend staff meetings and journal club. Lectures will be given relating to basic plastic surgery Grading scale: Pass/Fail including introduction to plastic surgery, surgical dermatology, congenital anomalies, hand and burns.

Coordinator: Assessment: Dr. Yaron Shoham Assessment will be based on attendance and participation.

Office phone: Course Content\ schedule and outlines: Email: The course starts on Sunday 07.30 and lasts for two weeks. The students come every day at 07.30 and disperse to participate at the varying working stations (ER, Office hours: out-patient clinic, operation theatres).

Course evaluation: Required reading: Debriefing at completion of all Nelligan`s Plastic and Reconstructive Surgery selectives.

Confirmation: 2019-20

Last update: January 2019 * All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students.

159 Ben-Gurion University of the Negev Medical School for International Health

Name of the selective: Radiology/Imaging Number of course: 481-8-4097

BGU Credits: 2.5 Course Description:

Aims of the course The selective in the Radiology Department will expose students to ECTS credits: the different aspects of radiology including computer tomography, ultrasound, MRI, PET CT, angiography and fluoroscopy. Academic year: 2019-20 Objectives of the course: The general radiology selective is structured to provide an overview of the basic Semester: 2 principles of diagnostic imaging, invasive radiology and an introduction to the fundamentals of diagnostic radiology.

Hours of instruction: 2 weeks Learning outcomes of the course: 1. To develop an appreciation of the complexity of diagnostic imaging including Location of instruction: an understanding of the types of available choices. Soroka University Medical Center 2. To gain an understanding of the clinical indications for obtaining studies, the Language of instruction: English relative risk/benefit of radiologic procedures and the basic technical aspects of how examinations are performed. 3. To learn limitations and contraindications of the diagnostic studies. Cycle: 1st

Position: Elective course Attendance regulation: Mandatory

Field of Education: MD Teaching arrangement and method of instruction: The morning conference will include a case presentation and Responsible department: MSIH discussion given by the attendant on call the previous night and then students will accompany and assist residents on their rounds. General prerequisites: Assessment:

Grading scale: Pass/Fail Tutor evaluation of the student's professional conduct and clinical perforamance

Work and assignments:  The students will be assigned at a workplace for a day rotating between different imaging modalities according to the internal schedule. Student’s personal interest might be taken into account.  At the end of the selective the students will present clinical case and relevant diagnostic studies with typical findings followed by brief discassion.  Students are required to cover one module/day from the following source: https://www.cchs.net/onlinelearning/cometvs10/pedrad/default.htm

Time required for individual work: in addition to attendance in class, the students are expected to do their assignment and individual work:

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1561156 Ben-Gurion University of the Negev Medical School for International Health

Coordinators: Course Content\ schedule and outlines

Prof. Ben Taragin The selective is structured from 8.00 AM until 3:00 PM. On Sunday, Tuesday and Friday there is a morning conference, while on Monday and Wednesday students Office phone : attend teaching session with a staff radiologist. During the day students will be assigned to workplaces where they can observe patient examinations, the working interpretive sessions and the interface of radiology with the referral services.

Email: [email protected] Required reading: 1. Felson’s Principles of Chest Roentgenology, 3rd Ed. Office hours: 2. Pediatric Radiology, 3rd Ed. Haller et al 3. 1. Ouellette H., Tétreault P.Clinical Radiology Made Ridiculously Simple To be announced at the first session. 4. 2. Fleckenstein P., Tranum-Jensen J. Anatomy in Diagnostic Imaging

Course evaluation: Additional literature: Debriefing at completion of course. On-line resources: Confirmation: 2019-20 For anatomy: Gray's Anatomy http://www.bartleby.com/107/ https://my.statdx.com/ Last update: For cases: January 2019 www.auntminnie.com Case in Point by ACR:http://caseinpoint.acr.org/ https://www.cchs.net/onlinelearning/cometvs10/pedrad/default.htm

For teaching topics: Learning radiology: http://www.learningradiology.com/ Radiology Assistant http://www.radiologyassistant.nl/ Rads Wiki:http://www.radswiki.net/ Radiopaedia:http://radiopaedia.org/

* All learning material will be available to the students on the course's website (Moodle)/ library/ electronic documents available to BGU students. 161 2

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