April 12th, 2019

The Peres Center for Peace, Tel-Aviv BREAST CANCER INNOVATIONS

The Israeli Society for Clinical Oncology and Radiation Therapy and Roche are Pleased to Invite You to an Enriching and Educating Meeting with our Distinguished Guest Speaker:

Prof. Charles E. Geyer

Please Send the Attached Registration Form to A.M Knasim No Later than April 1st 2019 E-mail: [email protected] Tel: 03-6081520 Fax: 03-6081522 Prof. Charles E. Geyer Friday, 12th April 2019

• Professor of 08:00-09:00 Welcome Reception • Harrigan, Haw, Luck Families Chair in Cancer Research 09:00-09:10 Opening Remarks • Virginia Commonwealth University, Massey Dr. Noa Efrat Ben-Baruch Cancer Center Head, Israeli Breast Cancer Group • Associate Director of Clinical Research Head, Department of Oncology Charles E. Geyer, Jr. is Professor of Medicine and the Harrigan, Haw, Luck Families Chair in Cancer Research at Virginia Commonwealth University Massey Chairmen: Dr. Georgeta Fried Cancer Center, an NCI-designated Cancer Center. He serves as Associate Director Head Breast Cancer Unit of Clinical Research for the Massey Cancer Center with oversight responsibility Rambam Medical Center for all cancer-related clinical research activities within the Center. Prof. Geyer Dr. Margarita Tokar has devoted most of his academic career on the design and conduct of multi- institutional, phase III clinical trials in breast cancer with a particular focus on Senior Oncologist the development of HER2 targeted therapies. He has served in several leadership Soroka University Medical Center positions for multi-institution research initiatives. These include vice-chair of the 09:10-09:30 Personalized Nanothechnologies in the National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Committee Management of Breast Cancer from 1999 until 2007, Associate Director of Medical Affairs from 2002 to 2006 and Director of Medical Affairs for NSABP from 2006 to 2011. Currently he serves as Prof. Avi Schroeder Chair of the NSABP Foundation Breast Cancer Committee, and medical oncology The Wolfson Department of Chemical, vice-chair of the NRG Oncology Breast Cancer Committee. Engineering, Technion Chairmen: Dr. Larissa Ryvo In 2008, he was appointed as a founding Co-chair for the NCI Cancer Treatment Evaluation Program Breast Cancer Steering Committee and received a Director’s Head, Oncology Department Award at the completion of his tenure in 2011. Prof. Geyer has co-authored over Assuta Academic Medical Center 80 peer-reviewed manuscripts including results of several landmark phase 3 Dr. Irina Lazarev trials conducted by the NSABP. He has also been active in leadership roles on Senior Oncologist collaborative global trials in breast cancer, having chaired or co-chaired Scientific The Legacy Heritage Oncology Center & Steering Committees on 5 phase III trials. He earned his bachelor’s and doctoral degrees from Texas Tech University in Lubbock, Texas and completed his internal Dr. Larry Norton Institute medicine residency and medical oncology fellowship at Baylor College of Medicine & Ben-Gurion University Affiliated in Houston, Texas.

4 5 Friday, 12th April 2019 (continued)

09:30-10:00 Modifying HER2 Positive Treatment in Early 10:40-11:00 Debate: Neo Adjuvant Therapy in HR Positive, Breast Cancer - Past, Present and Future HER2 Negative Breast Cancer Prof. Charles E. Geyer Moderator: Prof. Moshe Inbar Professor of Medicine Senior Oncology Consultant Harrigan, Haw, Luck Families Chair Assuta Medical Centers in Cancer Research Virginia Commonwealth University, Con: Dr. Karen Drumea Massey Cancer Center Director of the Oncology Associate Director of Clinical Research Outpatient Therapy Clinic Rambam Campus Chairmen: Dr. Noam Asna Head, Oncology Department Pro: Prof. Tamar Safra , Head, Onco-Gynecology Service Oncology Department Dr. Ora Rosengarten Sourasky Medical Center Head of Medical Gyneco-Oncology Unit Shaare Zedek Medical Center 11:00-11:40 New Horizon in Early Breast Cancer 2019 - Dilemmas, Practical Considerations and Future 10:00-10:40 St. Gallen International Consensus: Prospects The Optimal Treatment of Woman with Breast Cancer – Oncological, Surgical and Moderator: Dr. Noa Efrat Ben-Baruch Radiotherapy Aspects Head, Israeli Breast Cancer Group Dr. Hadar Goldvaser Head, Department of Oncology Senior oncologist Kaplan Medical Center Davidoff Cancer Center, Breast Unit Panel: Prof. Charles E. Geyer Beilinson , Professor of Medicine Prof. Dan Hershko Harrigan, Haw, Luck Families Chair Professor of Surgery, Head, Department of in Cancer Research Surgery A, Emek Medical Center, Virginia Commonwealth University, Massey Cancer Center Dr. Raphael Pfeffer Associate Director of Clinical Research Head, Oncology Institute, , Tel Aviv

6 7 Friday, 12th April 2019 (continued)

Prof. Bella Kaufman 12:20-12:50 Optimizing Treatment of Triple Negative Head, Breast Oncology Institute Breast Cancer , Tel Hashomer Prof. Charles E. Geyer Prof. Rinat Yerushalmi Professor of Medicine Director, Breast Cancer Unit Harrigan, Haw, Luck Families Chair Davidoff Center, Rabin Medical Center in Cancer Research Virginia Commonwealth University, Dr. Shani Paluch-Shimon Massey Cancer Center Director, Breast Oncology Unit Associate Director of Clinical Research Director, the Talya Center for Young Women with Breast Cancer, Shaare Zedek Medical Center 12:50-13:30 Case Studies Tumor Board Discussion - Illustrative Cases Incorporating Current and Prof. Beatrice Uziely New Data Head Oncology Ambulatory Services Unit Hadassah University Medical Center Case 1: The Role of Imunotherapy and PARP Inhibitors in Metastatic Triple Negative Breast Dr. Merav Ben-David Cancer Medical and Radiation Oncologist Dr. Rotem Merose Head, Breast Radiation Unit Senior Oncologist Chaim Sheba Medical Center Tel-Aviv Sourasky Medical Center Dr. Eran Sharon Case 2: The Challenge of Dealing with Rare TNBC Head, Breast Surgical Service Subtypes Rabin Medical Center Dr. Ofra Maimon Senior Oncologist 11:40-12:20 Brunch Break Sharett Institute of Oncology Chairman: Dr. Daniela Katz Hadassah University Medical Center Head of Breast and Sarcoma Services Moderator: Dr. Noa Efrat Ben-Baruch Assaf Harofeh Medical Center Head, Israeli Breast Cancer Group Head, Department of Oncology Kaplan Medical Center

8 9 Friday, 12th April 2019 (continued)

Panel: Prof. Charles E. Geyer Professor of Medicine Harrigan, Haw, Luck Families Chair in Cancer Research Virginia Commonwealth University, Massey Cancer Center Associate Director of Clinical Research Prof. Tamar Peretz Head, Sharett Institute of Oncology Director, the Center for Malignant Breast Diseases Hadassah University Medical Center Dr. Einav Nili Gal-Yam Head, Ambulatory Care Unit Deputy Head, Breast Cancer Unit Institute of Oncology Sheba Medical Center, Tel Hashomer Dr. Ella Evron Senior Oncologist Kaplan Medical Center Dr. Judith Sandbank Head, Department of Pathology Maccabi Health Services Roche Pharmaceuticals () Ltd. 6 Hacharash Street P.O.B. 6391 Hod Hasharon 4524079 Israel www.roche.co.il MP-1903-V2-3106