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Combination Medications Combination Medications WHAT ARE COMBINATION MEDICATIONS? Combination medications are pills, tablets, or injections that contain more than one medication to treat HIV. They are listed in the tables below. Pharmaceutical companies have been working hard to make their medications easier to take. Part of this effort has been to combine more than one medication into a single pill. These combinations are referred to as fixed-dose combinations (FDCs). Combinationantiretroviral therapy (ART), sometimes called highly active antiretroviral therapy (HAART), has revolutionized the management of HIV infection and rendered it a chronic manageable disease. The first FDC to treat HIV wasCombivir , manufactured by ViiV Healthcare. Combivir contains two nucleoside reverse transcriptase inhibitors (NRTIs): lamivudine and zidovudine. This was followed byTrizivir , also manufactured by ViiV Healthcare. Trizivir includes three NRTIs:abacavir , lamivudine, and zidovudine. Both Combivir and Trizivir are no longer widely used in the U.S. due to the frequency and severity of side effects. Be sure that you do not take a combination medication along with any of its components!For example, do not take Truvada (which contains emtricitabine and tenofovir DF) with tenofovir DF (Viread) or emtricitabine (Emtriva). Your healthcare provider will help you decide which HAART regimen is best for you; take your medications exactly as your healthcare provider tells you to. TABLE OF COMBINATION HIV MEDICATIONS Brand name Year Approved Individual Components Also Known As Manufacturer lopinavir – PI Kaletra* 2000 LPV / RTV AbbVie Inc. ritonavir – PI abacavir – NRTI Epzicom* 2004 ABC / 3TC ViiV Healthcare lamivudine – NRTI emtricitabine – NRTI Truvada* 2004 FTC / TDF Gilead Sciences tenofovir DF – NRTI efavirenz – NNRTI Atripla* 2006 emtricitabine – NRTI EFV / FTC / TDF Gilead Sciences tenofovir DF – NRTI emtricitabine – NRTI Complera 2011 rilpivirine -- NNRTI FTC / RPV / TDF Gilead Sciences tenofovir DF – NRTI elvitegravir – Integrase Inhibitor cobicistat – PK Enhancer QUAD Stribild 2012 Gilead Sciences emtricitabine -- NRTI EVG / COBI / FTC / TDF tenofovir DF – NRTI abacavir – NRTI Triumeq 2014 dolutegravir – Integrase Inhibitor ABC / DTG / 3TC ViiV Healthcare lamivudine – NRTI darunavir – PI Prezcobix 2015 DRV / COBI Janssen Therapeutics cobicistat – PK Enhancer atazanavir – PI Evotaz 2015 ATV / COBI Bristol-Myers Squibb cobicistat – PK Enhancer elvitegravir – Integrase Inhibitor cobicistat – PK Enhancer Genvoya 2015 EVG / COBI / FTC / TAF Gilead Sciences emtricitabine – NRTI tenofovir AF – NRTI emtricitabine – NRTI Odefsey 2016 rilpivirine – NNRTI FTC / RPV / TAF Gilead Sciences tenofovir AF – NRTI emtricitabine -- NRTI Descovy 2016 FTC/TAF Gilead Sciences tenofovir AF – NRTI dolutegravir – Integrase Inhibitor Juluca 2017 DTG / RPV ViiV Healthcare rilpivirine – NNRTI bictegravir – Integrase Inhibitor Biktarvy 2018 emtricitabine – NRTI BIC / FTC / TAF Gilead Sciences tenofovir AF – NRTI efavirenz – NNRTI Symfi and 2018 lamivudine – NRTI EFV / 3TC / TDF Viatris Symfi Lo* tenofovir DF – NRTI lamivudine – NRTI Temixys Cimduo 2018 Viatris tenofovir DF – NRTI 3TC / TDF doravirine – NNRTI Delstrigo 2018 lamivudine – NRTI DOR / 3TC / TDF Merck & Co., Inc. tenofovir DF – NRTI darunavir – PI cobicistat – PK Enhancer Symtuza 2018 DRV / COBI / FTC / TAF Janssen Therapeutics emtricitabine – NRTI tenofovir AF – NRTI dolutegravir – Integrase Inhibitor Dovato 2019 DTG / 3TC ViiV Healthcare lamivudine – NRTI cabotegravir – Integrase Inhibitor Cabenuva 2021 CAB / RPV ViiV Healthcare rilpivirine – NNRTI *Generic versions have been approved under the President's Emergency Plan for AIDS Relief (PEPFAR). Reviewed March 2021.
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