Subject Index to Volume 1'7: Biological Sciences*

January-Dece:nber 1980

Introdul ction The terms of the Subject Index for Volu me 77, January-December 1980, of the PROCEEDINGS OF THE NATIONAL ACA] )EMY OF SCIENCES USA (Biological Sciences) were chosen from titles, key terr ns, and abstracts of articles. The index terms are alphabetized by computer; nui abers, conformational prefixes, Greek letters, hyphens, and spaces between words aredisregarded in alphabetization. After each index term is printed the title of the Erticle (or a suitable modification of the title) and the appropriate page number. Tit [es are listed in alphabetical order under the index terms. Corrections to papers in which errors occurred are indexed under the term "Correction"as well as under the index term s selected for the paper itself. Organisms are indexed by their scientific names whe] i scientific names were provided in the papers; suitable cross-references are provi ded. Because the PROCEEDINGSurges autho rs to follow the tentative rules and rec- ommendations of the nomenclature comrmissions (e.g., for biochemistry, those proposed by the International Union of E iochemistry), an effort has been made to construct an index that conforms with t] lis policy. However, correction of errors in nomenclature was not attempted and t he index should not be looked upon as a reference for correct or recommended us. tge. In addition, some exceptions to the recommendations of the commissions were necessary. Index terms themselves are usually not abbreviated even if specific re( 'ommendations have been made by the commissions; and in some instances, wordsI within an index term were rearranged. (Thus, tRNA is indexed as "Ribonucleic acid, transfer.?') In general, analogs of compounds are indexed as the parent com] )ound. (Thus, dimethylbenzanthracene is indexed as "Benzanthracene, dimethyl-.' ') The "Recommended Name" from the 1978 recommendations of the Nomenclatur e Committee of the International Union of Biochemistry on the Nomenclature ar d Classification of [ Nomenclature (1978), Academic Press, I 4ew York] has been used for enzymes whenever Enzyme Commission (EC) num bers were published in the papers. EC numbers are listed as part'of the entry on ly if the EC number was printed in the paper. [Thus, some enzymes have two entri es, e.g., "Adenosinetriphosphatase"' and "Adenosinetriphosphatase (EC 3.6.1.3)."]

* Subject index for Physical Sciences begins on p. 7623.

754: Downloaded by guest on September 29, 2021 7542 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Abetalipoproteinemia Analysisof mechanismof fast axonaltransport by intracellularinjection see also Hyperapobetalipoproteinemia of potentiallyinhibitory macromolecules: Possible role of Inabilityof serumfrom abetalipoproteinemicsubjects to stimulate filaments,7448 proliferationof humansmooth muscle cells and dermalfibroblasts in Appearanceof cytoskeletalcomponents on the surfaceof leukemiacells vitro, 1511 and of lymphocytes transformed by mitogens and Epstein-Barr virus, Abscisicacid 4979 Abscisicacid content of oat leaves:Changes during senescence, 2050 ATP-drivensteady-state exchange of monomericand filamentousactin Acetate (EC 2.7.2.1) from Dictyostelium discoideum, 4610 Acetate kinase:A triple-displacementenzyme, 2626 Bioenergetic aspects and polymer length distribution in steady-state Acetobacterxylinum head-to-tail polymerization of actin or microtubules, 4803 Cellulosebiogenesis: Polymerization and crystallizationare coupled Calciumcontrol of intestinalmicrovillus cytoskeleton: Implications for processesin Acetobacterxylinum, 6678 regulationof microfilamentorganizations, 6458 Cooperativebinding of myosinsubfragment 1 to Acetonemetabolism in mice:Increased activity in mice heterozygousfor actin-troponin-tropomyosincomplex, 2616 obesity genes, 290 Cooperativebinding of subfragment1 to regulatedactin: Kinetic studies, N-Acetoxy-2-acetylaminofluorene 7209 Chemicalcarcinogen-modified DNA recognizedby a DNA-binding Cooperativeequilibrium binding of myosin subfragment1 to ,3201 actin-troponin-tropomyosincomplex: Theoretical model, 3186 Chemicalcarcinogen-modified DNA recognizedby a DNA-binding CytoskeletalF-actin patternsquantitated with fluorescein protein (correction),7510 isothiocyanate-phalloidin in normal and transformed cells, 6624 Conformationof poly(dG-dC).poly(dG-dC)modified by carcinogens Fluorescence staining of actin cytoskeleton in living cells with N-acetoxy-N-acetyl-2-aminofluoreneand 7-nitrobenz-2-oxa-1,3-diazole-phallacidin,980 N-hydroxy-N-2-aminofluorene,4597 Fluorescencestaining of actin cytoskeletonin living cells with Acetylcholine 7-nitrobenz-2-oxa-1,3-diazole-phallacidin(correction), 3747 see also Receptor,acetylcholine Immunologicaldifferences between from cardiacmuscle, skeletal Acetylcholine:Specific stimulated uptake by Torpedoelectric organ muscle, and brain, 2069 synapticvesicles, 6234 Recombinantplasmids'constructed containing rat muscle actin and Early nerve-musclesynapses in vitro releasetransmitter over myosinlight chain DNA sequences,960 postsynapticmembrane having low acetylcholinesensitivity, 644 Reversible translocation of cytoplasmic actin into the nucleus caused by Kinetic modelssuggest bimolecularreaction steps in axonal Na+-channel .dimethyl sulfoxide, 5268 gating,6582 a-Actinin Leptinotarsin:A presynapticneurotoxin that stimulatesrelease of Cytoskeletalproteins vinculin and a-actinin:Altered distributions in acetycholine,1219 culturedfibroblasts transformed by Rous sarcomavirus, 6687 Quantalrelease of acetylcholineexamined by currentfluctuation analysis Active avoidance at identifiedneuro-neuronal synapse of Aplysia, 1661 Enkephalinand fear-motivatedbehavior, 3729 Single channelcurrents from excised patches of muscle membrane,6930 Acyclovir (EC 3.1.1.7) Acyclovir inhibition of Epstein-Barr virus replication, 5163 Acetylcholinesterase:Photodestruction, 1980 Adaptation Clumpingof acetylcholinesteraseactivity in developingstriatum of Spatial frequencyspecific interactionof dot patternsand gratings,662 humanfetus and young infant, 1214 Adenine,isopentenyl- Collagen-tailedand hydrophobiccomponents of acetylcholinesterasein Isopentenyladenineas a mediatorof mevalonate-regulatedDNA Torpedomarmorata electric organ, 4464 replication,5842 Specific photoaffinitylabeling induced by energytransfer: Application to Adenosine irreversibleinhibition of acetylcholinesterase,6439' see also Receptor, adenosine Vasoactiveintestinal polypeptidein cholinergicneurons of exocrine Adenosine,2-chloro- glands:Functional significance of coexistingtransmitters for Putative centralpurinergic receptors: Biochemical characterization by vasodilationand secretion,1651 using 2-chloro[3H]adenosine,a stable analogof adenosine,6892 Acetyl-CoAcarboxylase (EC 6.4.1.2) Adenosine3',5'-cyclic monophosphate Fatty acid-requiringmutant of Saccharomycescerevisiae defective in see also Adenylate cyclase; Receptor, adenosine 3',5'-cyclic acetyl-CoAcarboxylase, 1814 monophosphate Regulationof acetyl-CoAcarboxylase: Properties of CoA activationof Actin nascent chains are substrates for cyclic AMP-dependent acetyl-CoAcarboxylase, 3351 in vivo, 910 N-Acetylglucosamine Adenylate cyclase and immunologic release of mediators from rat mast Phosphorylatedoligosaccharides in lysosomalenzymes: Identification of cells: and antagonist effects of purine- and ribose-modified a-N-acetylglucosamine(l)phospho(6)mannosediester groups,7074 adenosine analogs, 6800 N-Acetylglucosamine-6-sulfatesulfatase A "mute" catalytic subunit of cyclic AMP-dependent Sanfilippodisease type D: Deficiencyof N-acetylglucosamine-6-sulfate from rat muscle and its mode of activation, 2492 sulfataserequired for heparansulfate degradation,6822 Calcium and microtubule dependence for increased ornithine N-Acetylmuramyl-L-alany--D-isoglutamine decarboxylase activity stimulated by f- , dibutyryl Antiviralresponse elicited by a completelysynthetic antigen with cyclic AMP, or serum in a rat astrocytoma cell line, 995 built-in adjuvanticity,67,69 Calcium current modulation underlying presynaptic facilitation and Geneticallycontrolled formation of antibodyto a synthetic antigen behavioral sensitization in Aplysia: Mechanism, 6912 [poly(LTyr,LGlu)-poly(DLAla)--poly(LLys)] covalently bound to a Calcium-dependent hormonal regulation of amino acid transport and synthetic adjuvant(N-acetylmuramyl-L-alanyl-D-isoglutamine), 4933 cyclic AMP accumulation in rat hepatocyte monolayer cultures, 5953 Acetylserotoninmethyltransferase (EC 2.1.1.4) Catalyticsubunit of cyclic AMP-dependentprotein kinase: Pteridinesas nonretinalregulators of light-dependentmelatonin Microinjection enhances calcium action potentials of bag cell ,2415 in cell culture,7487 N-Acetyltransferase Changein rate of transcriptionof a eukaryoticgene in responseto cyclic see Arylamineacetyltransferase AMP, 7171 Acholeplasmalaidlawii Cyclic AMP accumulation in cultured brain cells: Regulation by secretin, Membranelipid physicalstate and modulationof Na+,Mg2+-ATPase vasoactive intestinal peptide, and somatostatin, 6907 activity in Acholeplasmalaidlawii B, 1255 Cyclic AMP: A role in expression of developmentally regulated genes in Acid-basetitration Dictyostelium discoideum, 1044 Net proton-hydroxylpermeability of largeunilamellar liposomes Cyclic AMP as a negative regulator of hormonally induced lactogenesis measuredby an acid-basetitration technique, 2038 in mouse mammary gland organ culture, 2093 al-Acid Cyclic AMP metabolism modulated by S-adenosylhomocysteine and Immunosuppressionby humanplasma al-acid glycoprotein:Importance S-3-deazaadenosylhomocysteine in mouse lymphocytes, 5639 of carbohydratemoiety, 6109 Desensitizationof enucleatedcells to hormonesand role of cytoskeleton Acid in control of normal hormonal response, 4798 Protein bodies of mung bean cotyledonsas autophagicorganelles, 428 Differential expression of type I and type II cyclic AMP-dependent Acid protein during cell cycle and cyclic AMP-induced growth Simultaneousexpression of mouse immunoglobulinsM and D is arrest, 3445 determinedby the same homologof chromosome12, 6793 :Deposition during reverse transformation of Chinese (EC 3.1.3.2) hamster ovary cells by cyclic AMP, 985 see also Gene, acid phosphataseI Growth of T-lymphoma cells in serum-free medium: Lack of involvement Synthesis of repressibleyeast acid phosphatasein vitro:Identification of of cyclic AMP pathwayin long-termcultures, 5993 multiplemRNAs and products,4504 Insulin-treated3T3-L1 adipocytes and cell-freeextracts derived from genes with mRNA levels controlledby phosphateconcentration: them incorporate 32p into ribosomal protein S6, 2641 Isolation, 6541 Intracellular injection of catalytic subunit of cyclic AMP-dependent Acousticmicroscopy protein kinase simulates facilitation of transmitter release underlying Cell wall appositionsand plant disease resistance:Acoustic microscopy behavioral sensitization in Aplysia, 7492 of papillae that block fungal ingress, 2046 Macromoleculewhich enhancesfluoride activation of adenylatecyclase: Acrosomereaction Partial purification and characterization, 4628 Calmodulinlocalization in mammalianspermatozoa, 2772 Persistenceof increasedplatelet cyclic AMP inducedby prostaglandin Actin El'after removalof the hormone,2946 see also Gene, actin Quercetininhibits Ca2+uptake 'but not Ca2+release by sarcoplasmic Actin nascent chains are substrates for cyclic AMP-dependent reticulum in skinned muscle fibers, 4435 phosphorylation in vivo, 910 Downloaded by guest on September 29, 2021 Proc. 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Regulationof cyclic AMP formationin brain tissue by a-adrenergic Time-resolved studies of ATP-requiring biological systems: Laser flash receptors:Requisite intermediacy of prostaglandinsof the E series, photolysisof caged ATP, 7237 3024- Adenosine5-triphosphate pyrophosphohydrolase(EC 3.6.1.8) Regulationof ornithinedecarboxylase activity by corticotropinin Membranelipid physical state and modulationof Na+,Mg2+-ATPase adrenocorticaltumor cell clones:Roles of cyclic AMP and cyclic activity in Acholeplasmalaidlawii B, 1255 AMP-dependentprotein kinase, 2767 Adenosylhomocysteinase(EC 3.3.1.1) -inducedhyperpolarization of an identified Aplysia neuronis Adenosinekinase-deficient human lymphoblastoid cell line: Resistance mediatedby cyclic AMP, 5013 to effects of deoxyadenosineon growth,S-adenosylhomocysteine Adenosine3',5'-cyclic monophosphate in microorganisms hydrolaseinactivation, and dATP accumulation,4292 Metabolitegene regulationof L-arabinoseoperon in Escherichiacoli Adenosylhomocysteine with indoleaceticacid and other indole derivatives,1768 CyclicAMP metabolismmodulated by S-adenosylhomocysteineand Yeast matingpheromone a factor inhibits adenylatecyclase, 1898 S-3-deazaadenosylhomocysteine in mouse lymphocytes, 5639 Adenosinedeaminase (EC 3.5.4.4) Phospholipidmethylation during chemotaxis in Dictyostelium Adenosinekinase-deficient human lymphoblastoid cell line: Resistance discoideum:Regulation by guanosine3',5'-cyclic monophosphate, 6996 to effects of deoxyadenosineon growth,S-adenosylhomocysteine S-Adenosylhomocysteinehydrolase hydrolaseinactivation, and dATP accumulation,4292 see Adenosylhomocysteinase ATP depletionas a consequenceof adenosinedeaminase inhibition in S-Adenosylmethionine man, 6157 Phospholipidmethylation during chemotaxis in Dictyostelium Deoxycytidinekinase-mediated toxicity of deoxyadenosineanalogs discoideum:Regulation by guanosine3',5'-cyclic monophosphate, 6996 towardmalignant human lymphoblasts in vitro and towardmurine Adenosylmethioninedecarboxylase (EC 4.1.1.50) L1210leukemia in vivo, 6865 Activationof early enzyme productionin small lymphocytesin response Immunedysfunction associated with adenosinedeaminase deficiency: to high, nonmitogenicconcentrations of concanavalinA, 3479 Animalmodel, 4899 Adenovirus Somaticcell genetics of adenosinedeaminase expression and severe AdenovirusDNA replicationin vitro: Characterizationof a protein combinedimmunodeficiency disease in humans,4211 covalentlylinked to nascent DNA strands,5105 Adenosine,3-deaza- Antibodiesspecific for carboxy-and amino-terminalregions of simian Circulardichroism of adenosinederivatives constrained in the syn form: virus 40 large tumorantigen, 5197 Calculations,3398 Comparative sequence analysis of inverted terminal repetitions from CyclicAMP metabolismmodulated by S-adenosylhomocysteineand differentadenoviruses, 3831 S-3-deazaadenosylhomocysteinein mouse lymphocytes,5639 DNA-dependenttranscription of adenovirusgenes in a soluble whole-cell Adenosine5'-diphosphate extract, 3855 Cooperativebinding of myosin subfragment1 to Genes for virus-associatedRNAi and RNAIIof adenovirustype 2: actin-troponin-tropomyosincomplex, 2616 Structure,2424 Adenosine,8-(a-hydroxyisopropyl)- Methylationof integratedadenovirus type 12 DNA sequencesin Circulardichroism of adenosinederivatives constrained in the syn form: transformed cells is inversely correlated with viral gene expression, 253 Calculations,3398 Multiple mRNA species for precursorto an adenovirus-encoded Adenosine5'-monophosphate glycoprotein:Identification and structureof signal sequence,6349 Anti-AMPantibody precipitation of multiply adenylylatedforms of Predictedstructure of two adenovirustumor antigens,3778 glutaminesynthetase fromEscherichia coli: Model relatingboth Regulationof early adenovirustranscription: A protein.productof early concentration and density of antigenic sites with -antigen region2 specificallyrepresses region 4 transcription,1893 interaction,7410 Two tumorantigens and their polypeptidesin adenovirustype Adenosinetriphosphatase 12-infectedand transformedcells, 2274 see also Adenosine5'-triphosphate pyrophosphohydrolase Vero cells injectedwith adenovirustype 2 mRNA produceauthentic Couplingof active ion transportand aerobicrespiratory rate in isolated viral polypeptidepatterns: Early mRNA promotesgrowth of renal tubules, 447 adenovirus-associated virus, 931 Proton-translocatingadenosinetriphosphatase complex from Vero cells injectedwith adenovirustype 2 mRNA produceauthentic chloroplasts:Biosynthesis and assembly,1361 viral polypeptidepatterns: Early mRNA promotesgrowth of Sodium-dependentsilicate transportin apochloroticmarine diatom adenovirus-associated virus (correction), 3070 Nitzschia alba, 6386 Adenovirus-associatedvirus Adenosinetriphosphatase(EC 3.6.1.3) Vero cells injectedwith adenovirustype 2 mRNA produceauthentic Apicalmembrane aminopeptidase appears at site of cell-cell contact in viral polypeptide patterns: Early mRNA promotes growth of culturedkidney epithelial cells, 4132 adenovirus-associatedvirus, 931 Calciumtranslocation mechanism in sarcoplasmicreticulum vesicles, Vero cells injectedwith adenovirustype 2 mRNA produceauthentic deducedfrom location studies of protein-boundspin labels, 2405 viral polypeptidepatterns: Early mRNA promotesgrowth of Chargeselectivity at lipid-proteininterface of membranous adenovirus-associated virus (correction), 3070 Na,K-ATPase,272 Adenylatecyclase Cytoplasmicallymade subunits of yeast mitochondrialF1-ATPase and Adenylatecyclase and immunologicrelease of mediatorsfrom rat mast cytochromec oxidaseare synthesizedas individualprecursors, not as cells: Agonistand antagonisteffects of purine-and ribose-modified polyproteins,3998 adenosineanalogs, 6800 Nigericin-stimulatedATPase activity in microsomalvesicles of tobacco Adrenergicregulation of intraocularpressure: Identification of callus, 5904 32-adrenergic-stimulatedadenylate cyclase in ciliaryprocess N,N'-Dicyclohexylcarbodiimidebinds specificallyto a single glutamyl epithelium,7420 residueof the proteolipidsubunit of mitochondrial Aggregationof luteinizinghormone receptors in granulosacells: Possible adenosinetriphosphatases from Neurospora crassa and Saccharomyces mechanismof desensitizationto the hormone,3440 cerevisiae,785 Agonist-promotedcoupling of 0-adrenergicreceptor with guanine Organizationof unc gene cluster of Escherichiacoli coding for nucleotideregulatory protein of the adenylatecyclase system, 775 proton-translocatingATPase of oxidativephosphorylation, 7005 Brain adenylatecyclase: Properties of the separatedcatalytic and Ouabain-binding-sitephotoaffinity probes that label both subunits of regulatoryunits, 6344 Na+,K+-ATPase,4529 Calmodulinactivates prokaryotic adenylate cyclase, 3841 Stimulatoryeffect of low ATP pools on transportof purine nucleosides Functionalimplantation of a solubilizedf-adrenergic receptor in in cells of Escherichiacoli, 2519 membraneof a cell, 760 Adenosine5'-triphosphate Hormone-inducedguanyl nucleotide binding and activationof adenylate see also Deoxyadenosine5'-triphosphate cyclase in Leydigcell, 5837 Activationfactor of liver ,5861 Insulin and serum increasenumber of receptorsfor vasopressinin a ATP-dependentconjugation of reticulocyteproteins with polypeptide kidney-derivedline of cells grownin a defined medium,5979 requiredfor proteindegradation, 1365 Adenylatecyclase (EC 4.6.1.1) ATP depletion as a consequenceof adenosinedeaminase inhibition in Anti-alprenololanti-idiotypic bind to /-adrenergic receptors man, 6157 and modulatecatecholamine-sensitive adenylate cyclase, 7385 ATP-drivensteady-state exchange of monomericand filamentousactin Clusterformation of opiate (enkephalin)receptors in neuroblastoma from Dictyostelium discoideum, 4610 cells: Differences between agonists and antagonists and possible Bioenergeticaspects and polymerlength distributionin steady-state relationshipsto biologicalfunctions, 3038 head-to-tailpolymerization of actin or microtubules,4803 Cyclic AMP metabolism modulated by S-adenosylhomocysteine and IncreasedATP inhibitionof liver phosphofructokinasefrom genetically S-3-deazaadenosylhomocysteinein mouse lymphocytes,5639 diabetic mice, 2497 Distal nephronof rat kidney:A target site for glucagon,3422 Measurementof changesin high-energyphosphates in the cardiaccycle Inhibitingthe onset of hormone-induceddesensitization of viable by using gated 31Pnuclear magnetic resonance, 3654 thymocytes by NA-tosyl-L-lysine chloromethyl ketone, 5967 Membranepermeability: Control by externaland internalATP in 3T6 Macromoleculewhich enhancesfluoride activation of adenylatecyclase: cells grownin serum-freemedium, 2103 Partial purificationand characterization,4628 Noninvasive31P NMR probesof free Mg2+,MgATP, and MgADP in Naturallysoluble component(s)that confer(s)guanine nucleotide and intact Ehrlichascites tumor cells, 2487 fluoridesensitivity to adenylatecyclase, 3836 Prolongedderangements of canine myocardialpurine metabolismafter a Persistenceof increasedplatelet cyclic AMP induced by prostaglandin brief coronaryartery occlusion not associatedwith anatomicevidence E1 after removalof the hormone,2946 of necrosis,5471 Photoaffinitylabel for ,-adrenergic receptor:Synthesis and effects on Proposedrole of ATP in protein breakdown:Conjugation of isoproterenol-stimulatedadenylate cyclase, 4449 with multiple chains of polypeptideof ATP-dependentproteolysis, Regulationof ornithinedecarboxylase activity by corticotropinin 1783 adrenocorticaltumor cell clones:Roles of cyclic AMP and cyclic Stimulatoryeffect of low ATP pools on transportof purine nucleosides AMP-dependentprotein kinase,2767 in cells of Escherichiacoli, 2519 Regulatorycomponent of adenylatecyclase: Purification, 6516 Subclassesof externaladenosine receptors, 2551 Downloaded by guest on September 29, 2021 7544 Biological Sciences Subject Index Proc. 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Yeast mating pheromone a factor inhibits adenylate cyclase, 1898 Alamethicin Adenylatedeaminase Lipid phase transitionin planarbilayer membrane and its effect on see AMP deaminase carrier-and pore-mediatedion transport,3403 Adenylylation Alanyl-tRNAsynthetase Synthesis of glutaminesynthetase regulated by PU protein in Klebsiella Mass spectraof partialprotein hydrolysates as a multiplephase check aerogenes, 2636 for long polypeptidesdeduced from DNA sequences:NH2-terminal Adipocyte segmentof alaninetRNA synthetase,6531 see also Cell, fat; Preadipocyte Coordinate modulation of D- transport activity and bilayer Fetal rat liver cell line establishedthat retainsdifferentiated liver fluidity in plasma membranes derived from control and insulin-treated functions,2731 adipocytes, 915 Albumin,serum Differences in organizational structure of insulin receptor on rat AlbuminmRNA absent in liver of analbuminemicrats, 3215 adipocyte and liver plasma membranes: Role of disulfide bonds, 4692 AlbuminNaskapi variant in North AmericanIndians and Eti Turks, Insulin-treated3T3-L1 adipocytes and cell-freeextracts derivedfrom 5480 them incorporate32p into ribosomalprotein S6, 2641 Aminoacid substitutionsite in a new variantof humanserum albumin, Interferon inhibits conversion of 3T3-L1 mouse fibroblasts into albuminMexico-2, 2505 adipocytes, 4099 Coordinateregulation of two estrogen-dependentgenes in avian liver, Interferoninhibits conversionof 3T3-L1 mouse fibroblastsinto 4474 adipocytes (correction), 6941 Mechanismof capacitation:Albumin-mediated changes in plasma Vascularendothelial :Potent stimulationby differentiated membranelipids duringin vitro incubationof rat spermcells, 1546 3T3 adipocytes, 6007 Alcoholdehydrogenase (EC 1.1.1.1) Adrenalgland Digitalis metabolismand humanliver alcoholdehydrogenase, 924 Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: Drosophilaalcohol dehydrogenase gene: Isolation and partial Action on (s) and its inhibitor(s), 5711 characterization,5794 Enkephalin biosynthetic pathway: Proteins of 8000 and 14,000 daltons in New molecularforms of humanliver alcoholdehydrogenase: Isolation bovine adrenal medulla, 5018 and characterization of ADHIndianapolis, 5784 Enkephalins and enkephalin-containing polypeptides: Release from Alcoholism perfused beef adrenal glands, 7423 New molecularforms of humanliver alcoholdehydrogenase: Isolation Probableprecursors of [Leu]enkephalinand [Met]enkephalinin adrenal and characterizationof ADHIndianapolis,5784 medulla: Peptides of 3-5 kilodaltons, 1681 Aldolase Studies with [35S]methionineindicate that the 22,000-dalton see Fructose-bisphosphatealdolase [Met]enkephalin-containing protein in chromaffin cells is a precursor Aldosterone of [Met]enkephalin, 6889 Glyoxylatecycle in toad urinarybladder: Possible stimulationby Adrenocorticotropichormone aldosterone,1521 see also Corticotropin Membrane-boundkallikrein and renin in the kidney:Activation, 4975 Adrenocorticotropin Mineralocorticoidtarget sites: Identificationin isolated rabbitcortical Cycloheximide-induced reversal of adrenocorticotropin effects on nephron,3672 steroidogenesis and adrenal phospholipids in vivo: Kinetic aspects, Alkalinephosphatase (EC 3.1.3.1) 7189 Alkalinephosphatase loci: Expressionin mammaliantissues, 2857 Aedes aegypti Placental alkalinephosphatase in nonmalignanthuman cervix, 4226 Anti-gamete monoclonal antibodies synergistically block transmission of Alkalinephosphodiesterase I malaria by preventing fertilization in mosquito, 6797 see PhosphodiesteraseI Aequorin Allatohibin induces rapid increase in [Ca2+]inof Xenopus laevis Neuroendocrineregulation of corpusallatum activity in Manducasexta: oocytes, 1534 Sequentialneurohormonal and nervousinhibition in the last-instar Aerobicrespiration larva,4407 Couplingof active ion transportand aerobicrespiratory rate in isolated Alloxan renal tubules, 447 Alloxan:Enzymatic reduction by thioredoxinand NADPH-thioredoxin Age structure reductase,5149 Competitive intransitivity and size-frequency distributions of interacting populations, 5355 Anti-alprenololanti-idiotypic antibodies bind to f-adrenergicreceptors Agglutinin and modulatecatecholamine-sensitive adenylate cyclase, 7385 Allogeneic hemopoietic stem cell transplantation using mouse spleen Macromolecularf-adrenergic antagonists discriminating between cells fractionated by lectins: In vitro study of cell fractions, 1164 receptorand antibody,2219 Antibody helper and antibody suppressor human T cells separated by Alprenolol,dihydro- using soybean agglutinin, 6778 ,3-Adrenergicreceptors and guaninenucleotide sites: Interactionin Peanut agglutinin receptors expressed on virus-induced preleukemic cells turkey erythrocytemembranes, 3801 in mice, 2244 Altruism Positive in a (dissected) lectin-membrane glycoprotein Kin selection:Effect of phenotypicvariation, 7506 binding event, 3788 Amanitaphalloides Aging Calciumdependence of phalloidin-inducedliver cell death, 1177 see also Senescence, leaf Ameboidmotion Altered enolase in aged Turbatrix aceti results from conformational Autonomousmovements of cytoplasmicfragments, 6639 changes in the enzyme, 5865 Amiloride Crystalline ribosomes are present in brains from senile humans, 2260 Amilorideinhibits murineerythroleukemia cell differentiation:Evidence Hormone-dependent functional epithelial cells from rat thyroids: for a Ca2+requirement for commitment,5948 Culture, 3455 Aminoacid Lipid fluidity markedly modulates binding of serotonin to mouse brain see also Transport,amino acid;specific aminoacids membranes, 7463 Aminoacid benzyl ester Production of auto-anti-idiotypic antibody during normal immune Antisicklingactivity of amino acid benzyl esters, 181 response: Changes in auto-anti-idiotypic antibody response and Aminoacid sequence idiotype repertoire associated with aging, 6788 see also Protein synthetic errors do not increase during aging of cultured human Amino acid sequenceof the T4 DNA helix-destabilizingprotein, 4614 fibroblasts, 1885 Amino acid sequenceof variableregion of a humanA chain:Location of Superoxide dismutase: Correlation with life-span and specific metabolic a possibleJH segment,3239 rate in primate species, 2777 Amino-terminalamino acid sequenceof humanleukocyte interferon, Agmenellumquadruplicatum 5102 Transformation in Agmenellum quadruplicatum, 6052 Amino-terminalsequence and processingof precursorof -specific Agrobacteriumtumefaciens bindingprotein, and evidencefor conformationaldifferences between Agropine in "null-type" crown gall tumors: Generality of the opine precursorand matureform, 2005 concept, 2693 Capsidprotein of SemlikiForest virus has clustersof basic amino acids Plasmid-dependent temperature-sensitive phase in crown gall and prolinesin its amino-terminalregion, 6376 tumorigenesis, 2688 Kchain joining segmentsand structuraldiversity of antibodycombining Proteins encoded by Agrobacterium tumefaciens Ti plasmid DNA sites, 4270 (T-DNA) in crown gall tumors, 2666 Covalentstructure of humanhaptoglobin: A serine proteasehomolog, Recombination between higher plant DNA and Ti plasmid of 3388 Agrobacterium' tumefaciens, 6448 DNA sequenceencoding NH2-terminal peptide involvedin transportof X T-DNA from Agrobacterium Ti plasmid is in the nuclear DNA fraction receptor, an Escherichia coli secretory protein, 2621 of crown gall tumor cells, 4060 Elongation factor Tu from Escherichia coli: Primary structure, 1326 Agropine Heavy chain of the H-2Kk histocompatibility antigen: Structure, 4239 Agropine in "null-type" crown gall tumors: Generality of the opine Human factor D: amino acid sequence, 4938 concept, 2693 Human fibroblast interferon: NH2-terminal amino acid sequence, 5716 Air pollution Isolation and structure of pro-somatostatin: A putative somatostatin Ambientair concentrationof sulfurdioxide affects flight activity in bees, precursorfrom pig hypothalamus,4489 5631 y-Lipotropin from human pituitary glands: Isolation and amino acid Akv virus sequence, 7214 Most sequence differences between genomes of Akv virus and a Mass spectra of partial protein hydrolysates as a multiple phase check leukemogenic Gross A virus passaged in vitro are located near the 3' for long polypeptides deduced from DNA sequences: NH2-terminal terminus, 4359 segment of alanine tRNA synthetase, 6531 Downloaded by guest on September 29, 2021 Proc. 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Mouse immunoglobulin a chain (MOPC 511): Complete amino acid Anacystis nidulans sequence, 4909 TransposonTn901introduced into a plasmid of Anacystis nidulans: Multiple mRNA species for precursorto an adenovirus-encoded';" Preparation for cloning in cyanobacteria, 1570 glycoprotein: Identification and structure of signal sequence, 6349 Anaerobic growth N,N'-Dicyclohexylcarbodiimide binds specifically to a single glutamyl Halobacteria:Anaerobic growth, 3821 residue of the proteolipid subunit of mitochondrial Analbuminemia adenosinetriphosphatases from Neurospora crassa and Saccharomyces Albumin mRNA absent in liver of analbuminemic rats, 3215 cerevisiae, 785 Analgesic Nucleotide sequence and expression of Escherichia coli trpR, structural see also Anesthetic gene for trp aporepressor, 7117 Analgesicactivity of naturallyoccurring heptapeptide Ovine hypothalamic somatostatin-28 and somatostatin-25: Primary [Met]enkephalin-Arg6-Phe7, 5512 structure, 6827 f-Endorphinomission analogs: Dissociation of immunoreactivityfrom Partial sequence of human complement component factor B: Novel type other biologicalactivities, 3211 of serine protease, 4923 Peptide inhibitorof morphine-and 3-endorphin-inducedanalgesia, 5525 Primary structure of major outer II* (ompA protein) Anaphylaxis of Escherichia coli K-12, 4592 see also Slow reacting substance Two neuroactive peptides that cause bag cell afterdischarge and Leukotrienes C-1 and D: Comparative airway and vascular activities in -laying in Aplysia: Purification and primary structure, 2328 vivo and in vitro, 4354 Vesicular stomatitis virus glycoprotein is anchored in viral membrane by Slow reacting substances of anaphylaxis: Identification of leukotrienes a hydrophobic domain near the COOH terminus, 3884 C-1 and D from human and rat sources, 3710 Aminoacid sequence,homology Androctonusaustralis Hector Amyloid-related apoprotein (SAA) from human high density lipoprotein: Binding of sea anemonetoxin to receptorsites associatedwith gating Isolation and characterization, 6860 system of sodiumchannel in synapticnerve endings in vitro, 1646 Complete amino acid sequence of pooled papain-solubilized HLA-A, -B, Androgen and -C antigens: Relatedness to immunoglobulins and internal see also Protein, androgen-binding;specific androgens homologies, 1129 Photoaffinitylabeling of rat androgen-bindingprotein, 234 heavy chain: Model based upon structural homology, 3393 Anemia Iron proteinsfrom the nitrogenfixation complexesof Azotobacter see also Sickle cell disease vinelandii, Clostridium pasteurianum, and Klebsiella pneumoniae, Isozymesof humanphosphofructokinase: Identification and subunit 3826 structuralcharacterization of a new system, 62 Origins of metabolic diversity: Substitution of homologous sequences Molecularabnormality of phosphoglyceratekinase-Uppsala associated into genes for enzymes with different catalytic activities, 5365 with chronic nonspherocytic hemolytic anemia, 5461 Partial amino acid sequence of human factor D: Homology with serine Anemoniasulcata proteases, 1116 Binding of sea anemone toxin to receptor sites associated with gating Partial amino acid sequences of murine fourth component of system of sodium channel in synaptic nerve endings in vitro, 1646 complement (C4): Demonstration of homology with human C4 and Anesthetic identification of the amino-terminal subunit in pro-C4, 4275 see also Analgesic Primary structural studies of an H-2L molecule confirm that it is a receptor sites are coupled to receptors, 7468 unique gene product with homology to H-2K and H-2D antigens, 1134 Local anesthetics inhibit induction of ornithine decarboxylase by tumor Urotensin II: A somatostatin-like peptide in the caudal neurosecretory promoter 12-O-tetradecanoylphorbol 13-acetate, 5312 system of fishes, 5021 Angiogenesis Amino acid:tRNA Tumor growth in animals controlled by infusion of an angiogenesis Conformational changes during : Role of water in the inhibitor,4331 transition state, 3374 Angiotensin 9-Aminoacridine Aminoacid side chain conformationin angiotensinII and analogs: 9-Aminoacridine: Site exclusion and sequence specificity in binding to Correlatedresults of circulardichroism and 1H nuclearmagnetic deoxytetranucleotide dpApGpCpT, 6453 resonance, 82 y-Aminobutyricacid Specific inhibition of renin by an angiotensinogen analog: Sodium see also Receptor, y-aminobutyricacid depletionand renin-dependenthypertension, 5476 Barbiturate receptor sites are coupled to benzodiazepine receptors, 7468 Aniridia,autosomal dominant Bicuculline enhances a negative component and diminishes a positive Autosomaldominant aniridia: Probable linkage to acid phosphatase-1 component of visual evoked cortical potential in cats, 7476 locus on chromosome 2, 1580 Interplexiform cell in cat retina: Identification by uptake of Anomalousscattering y-[ H]aminobutyric acid and serial reconstruction, 658 White lines in L-edge x-ray absorptionspectra and their implicationsfor Release of immunoreactive somatostatin from hypothalamic cells in anomalousdiffraction studies of biologicalmaterials, 5884 culture: Inhibition of y-aminobutyric acid, 5552 Ant 2-Aminoisobutyricacid see Oecophylla longinoda Calcium-dependent hormonal regulation of amino acid transport and Anthopleuraelegantissima cyclic AMP accumulation in rat hepatocyte monolayer cultures, 5953 Clone-specificcellular recognition in a sea anemone,6667 3-Amino-l-methyl-5H-pyrido[4,3-b]indole Correlation between DNA affinity and mutagenicity of several see specific 3-amino-l-methyl-5H-pyrido[4,3-b]indoles, 1427 Antibody Aminomethyltrioxalen see also Autoantibody; Immunoglobulin Electron microscope study of duck globin mRNA precursor crosslinked Anti-alprenololanti-idiotypic antibodies bind to l-adrenergicreceptors in situ, 4683 and modulate catecholamine-sensitive adenylate cyclase, 7385 Aminopeptidase Anti-AMPantibody precipitation of multiply adenylylatedforms of Aminopeptidase allele frequency dine maintained by natural selection, glutamine synthetase from Escherichia coli: Model relating both 5385 concentration and density of antigenic sites with antibody-antigen Aminopeptidase (EC 3.4.11.2) interaction,7410 Apical membrane aminopeptidase appears at site of cell-cell contact in Antibodies from myasthenic patients that compete with cholinergic cultured kidney epithelial cells, 4132 agents for binding to nicotinic receptors, 4326 2-Aminopurine Antibodiesspecific for carboxy-and amino-terminalregions of simian Deoxyribonucleotide pools, base pairing, and sequence configuration virus 40 large tumor antigen, 5197 affecting bromodeoxyuridine- and 2-aminopurine-induced Antibodies specific to choline acetyltransferase: Preparation from bovine mutagenesis, 1801 caudate nucleus and immunohistochemical localization of the enzyme, Single amino acid substitution mutants of aspartate 7453 carbamoyltransferase: Isolation and preliminary characterization, 3249 Antibody directed against Friend leukemia virus stimulates DNA Aminopurine,6-benzyl- synthesis in subpopulation of mouse B lymphocytes, 1486 Cytokinin inhibition of respiration in mitochondria from six plant Antibody helper and antibody suppressor human T cells separated by species, 4731 using soybean agglutinin, 6778 Cytokinin inhibition of respiration in mitochondria from six plant Antibody-independentactivation of alternativecomplement pathway by species (correction), 6941 measles virus-infected cells, 559 Amniotic fluid Antigen-specificinduction and regulationof antibodysynthesis in a-Fetoprotein: Inhibitory effect on binding of myasthenia gravis culturesof humanperipheral blood mononuclearcells, 1139 antibody to acetylcholine receptor, 3635 Anti-mitochondrialantibody: Localization in experimentalcanine Structural basis for apparent heterogeneity of collagens in human myocardialinfarcts, 6856 basement membranes: Type IV procollagen contains two distinct Antiserum to the rat liver glucocorticoid receptor, 3893 chains, 745 Cell surfacemolecule involved in aggregationof embryonicliver cells, AMP deaminase (EC 3.5.4.6) 4831 Adenylate deaminase binding to synthetic thick filaments of myosin, Clonalanergy: Persistence in tolerant mice of antigen-bindingB 7186 lymphocytesincapable of respondingto antigen or mitogen, 1602 Amyloid-relatedapoprotein Clonal antibodies for core protein of , Amyloid-related apoprotein (SAA) from human high density lipoprotein: 3971 Isolation and characterization, 6860 Effect of cleavinginterchain disulfide bridgeson radiusof gyrationand Anabaena maximumlength of anti-poly(D-alanyl)antibodies before and after Blue-green algae fixation gene: Identification by using reactionwith tetraalaninehapten, 117 heterologous DNA hybridization probes, 186 a-Fetoprotein: Inhibitory effect on binding of myasthenia gravis Cyanobacterial nifH gene coding for nitrogenase reductase: Nucleotide antibody to acetylcholine receptor, 3635 sequence, 6476 Downloaded by guest on September 29, 2021 7546 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Frequency and levels of antibodies to Epstein-Barr virus-specific DNase Antigen,histocompatibility are elevated in patients with nasopharyngealcarcinoma, 6162 see also Majorhistocompatibility complex Genetically controlled formation of antibody to a synthetic antigen Cell cycle and differentialexpression of HLA-A,Band HLA-DRantigens [poly(LTyr, LGlu)-poly(DLAla)--poly(LLys)] covalently bound to a on humanB lymphoidcells, 7297 synthetic adjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine), 4933 Cellularinteractions in generationof cytolytic T lymphocyteresponses: Germinal mutation detection in vivo with monospecific antibody against Role of Ia-positivesplenic adherentcells in presentationof H-2 lactate dehydrogenase-X, 7352 antigen, 6091 Humans have antibodies capable of recognizing oncoviral : Completeamino acid sequenceof pooled papain-solubilizedHLA-A, -B, Demonstration that these antibodies are formed in response to cellular and -C antigens: Relatedness to immunoglobulins and internal modification of glycoproteins rather than as consequence of exposure homologies, 1129 to virus, 1617 During ontogeny, Ia-bearing accessory cells are found early in the IgM antibodies induce production of antibodies of the same specificity, thymus but late in the spleen, 1597 1125 Gammaray-induced loss of expressionof HLA and glyoxalaseI alleles in Liver tumors distinguished by immunofluorescence microscopy with lymphoblastoid cells, 4251 antibodies to proteins of intermediate-sized filaments, 4948 Heavy chain of the H-2Kk histocompatibility antigen: Structure, 4239 Naturally occurring anti-spermine antibody in normal rabbit serum, 2904 HLA antigen-related restriction of T lymphocyte cytotoxicity to Productionof auto-anti-idiotypicantibody during normal immune Epstein-Barrvirus, 4247 response:Changes in auto-anti-idiotypicantibody response and H-2 restrictionas a consequenceof intentionalpriming: T cells of fully idiotype repertoireassociated with aging,6788 allogeneicchimeric mice and of normalmice respondto foreign Selective killing of normalor neoplasticB cells by antibodiescoupled to antigensin context of H-2 determinantsnot encounteredon thymic A chain of , 5419 epithelialcells, 7390 Serologicalsurvey of normalhumans for naturalantibody to cell surface Inheritanceof acquiredimmunological tolerance to foreign antigensof melanoma,4260 histocompatibilty antigens in mice, 2871 Specificity of human antibodies to oncovirus glycoproteins: Recognition Inheritanceof acquiredimmunological tolerance to foreign of antigen by natural antibodies directed against histocompatibilityantigens in mice (correction),4390 structures, 1622 Lateraldistribution and diffusionof C3b receptorof complement,HLA Antibody,monoclonal antigens,and lipid probesin peripheralblood leukocytes,6587 Antibody-directed cytotoxic agents: Use of to direct Lymphocyte surface properties altered by insertion of foreign functional action of toxin A chains to colorectal carcinoma cells, 4539 componentsof plasmamembrane, 7247 Anti-gametemonoclonal antibodies synergistically block transmissionof Molecularcloning of a humanhistocompatibility antigen cDNA malaria by preventing fertilization in mosquito, 6797 fragment,6081 Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent Primarystructural studies of an H-2L moleculeconfirm that it is a cell-type-specific toxin, 5483 unique gene productwith homologyto H-2K and H-2D antigens,1134 Cell cycle and differential expression of HLA-A,B and HLA-DR antigens Syngeneic tumor cells can induce alloreactive T killer cells: Biological on human B lymphoid cells, 7297 role for transplantationantigens, 5409 Cell surface antigens of human malignant melanoma: Definition of six T-cell-dependentB-cell stimulationis H-2 restrictedand antigen antigenic systems with mouse monoclonal antibodies, 6114 dependent only at the resting B-cell level, 1612 Cell surface protein, p97, identified in human melanomas and certain Antigen, I other neoplasms, 2183 I and i antigens of human peripheral blood lymphocytes cocap with Discretestages of humanintrathymic differentiation: Analysis of normal receptors for concanavalin A, 376 thymocytesand leukemiclymphoblasts of T-cell lineage, 1588 Membrane differentiation in human erythroid cells: Unique profiles of Functional characteristics of human T-cell subpopulations distinguished cell surface glycoproteins expressed in erythroblasts in vitro from by a monoclonal antibody, 1607 three ontogenic stages, 3474 Generation of human monoclonal antibodies reactive with human Antigen,iB mammary carcinoma cells, 6841 Embryonic-fetal erythroid characteristics of a human leukemic cell line, Human-humanhybridomas producing monoclonal antibodies of 3509 predefined antigenic specificity, 5429 Membranedifferentiation in humanerythroid cells: Unique profilesof Human melanoma cell surfaces: Dissection with monoclonal antibodies, cell surfaceglycoproteins expressed in erythroblastsin vitro from 7287 three ontogenic stages, 3474 Hybridoma proteins expressing the predominant idiotype of the Antigen,Lyt antiazophenylarsonate response of A/J mice, 1120 Alloantigen-inducedT-cell proliferation:Lyt phenotypeof responding Microtubule-associatedproteins: A monoclonalantibody to MAP2 binds cells and blockingof proliferationby Lyt antisera,2890 to differentiated neurons, 4741 Antigen,polysaccharide Molecular dissection of Rauscher virus gp70 by using monoclonal Native polysaccharide antigen of type Ia group B Streptococcus: antibodies:Localization of acquiredsequences of related envelopegene Structureand serology,2931 recombinants, 4524 Antigen,synthetic Monoclonal antibodies against human monocytes: Initial Antiviral response elicited by a completely synthetic antigen with characterization, 6764 built-in adjuvanticity,6769 Monoclonal antibodies against major glycoprotein (gp350/220) of Geneticallycontrolled formation of antibodyto a synthetic antigen Epstein-Barrvirus neutralizeinfectivity, 5307 [poly(LTyr,LGlu)-poly(DLAla)--poly(LLys)] covalently bound to a Monoclonalantibodies against trophectoderm-specific markers during synthetic adjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine), 4933 mouse blastocyst formation, 4113 Antigen,T Monoclonal antibodies specific for carcinoembryonic antigen and see Antigen,tumor produced by two hybrid cell lines, 563 Antigen,transplantation Monoclonal antibodies to f-adrenergic receptors: Use in purification and Syngeneictumor cells can induce alloreactiveT killer cells: Biological molecular characterization of f-receptors, 7034 role for transplantationantigens, 5409 Monoclonal antibodies to estrophilin: Probes for study of estrogen Antigen,tumor receptors, 157 Amplificationof integratedviral DNA sequencesin polyoma Monoclonalantibodies to humanestrogen receptor, 5115 virus-transformed cells, 3850 Monoclonalantibodies to sucrase/isomaltase:Probes for study of Antibodiesspecific for carboxy-and amino-terminalregions of simian postnatal development and biogenesis of intestinal microvillus virus 40 large tumor antigen, 5197 membrane, 6629 Cell surface antigens of human malignant melanoma: Definition of six Monoclonal antibodies used to probe acetylcholine receptor structure: antigenicsystems with mouse monoclonalantibodies, 6114 Localization of main immunogenic region and detection of similarities Cell surfaceprotein, p97, identifiedin humanmelanomas and certain between subunits, 755 other neoplasms, 2183 Monoclonal antibody against a 250,000-dalton glycoprotein of Codingcapacity of a 35%fragment of polyomavirus genomeis sufficient Epstein-Barr virus identifies a membrane antigen and a neutralizing to initiate and maintain cellular transformation, 3278 antigen, 2979 Cytoplasmictransfer of DNA containingsimian virus 40 sequencesinto Monoclonalantibody that defines an immunoregulatoryT cell subset for mouse 3T3 cells, 2844 immunoglobulinsynthesis in humans:Characterization, 2914 Deletions covering putative promoter region of early mRNAs of simian Transformation-related antigens identified by monoclonal antibodies, virus 40 do not abolishT-antigen expression, 3865 3234 Differentialaffinities of simian virus 40 largetumor antigenfor DNA, Antigen 220 Clonalanergy: Persistence in tolerant mice of antigen-bindingB DNA-transformed murine teratocarcinoma cells: Regulation of lymphocytesincapable of respondingto antigen or mitogen, 1602 expression of simian virus 40 tumor antigen in stem versus Antigen,blood group differentiatedcells, 4875 Multiple componentsof blood groupA and B antigensin human Generation of human monoclonal antibodies reactive with human erythrocytemembranes and their differencebetween A1 and A2 status, mammarycarcinoma cells, 6841 2951 Host nuclearproteins expressed in simian virus 40-transformedand Antigen,carcinoembryonic -infectedcells, 97 Monoclonalantibodies specific for carcinoelnbryonicantigen and Humanmelanoma cell surfaces:Dissection with monoclonalantibodies, producedby two hybridcell lines, 563 7287 Antigen,Gix Mechanismof interferonaction: Simian virus 40-specificearly Gix antigen expression: Relationship to of murine leukemia polypeptides synthesized in untreated and interferon-treated monkey virus glycoprotein, 6420 kidney cells, 2419 Antigen, hepatitis B Monoclonal antibodies specific for carcinoembryonic antigen and a agent: Association of 6 antigen with hepatitis B surface antigen and producedby two hybridcell lines, 563 RNA in serum of 6-infected chimpanzees, 6124 Polyomalarge tumor antigen is not requiredfor tumorigenesismediated by viral DNA, 1336 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7547

Predictedstructure of two adenovirustumor antigens,3778 Argininosuccinatesynthetase (EC 6.3.4.5) Presence of allograft-rejection resistance in simian virus 40-transformed Humlan-argininosuccinatesynthetase gene: Expressionin hamster hamster cells and its possible role in tumor development, 2886 transferents,4234 Resistance of simian virus 40-transformed hamster cells to cytolytic Arogenate effect of activatedmacrophages: Possible factor in species-specificviral Arogenate(pretyrosine) is an obligatoryintermediate of L- oncogenicity,6773 biosynthesis: Confirmation in a microbial mutant, 1270 RibosomalRNA genes in human-mousehybrid cells: Reactivationby Arogenate dehydrogenase 12-O-tetradecanoylphorbol13-acetate, 1566 Arogenate (pretyrosine) is an obligatory intermediate of L-tyrosine Simian virus 40 and polyomavirus stimulate overallcellular RNA and biosynthesis: Confirmation in a microbial mutant, 1270 proteinsynthesis, 1476 Aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) Simian virus 40 early transcription:Regulation in vitro by a purified Induction of translatable mRNA for dopa decarboxylase in Drosophila: tumor antigen, 5706 Early responseto ecdysterone,4175 Simian virus 40 origins defective in tumor antigen binding and DNA Arrheniusplot replication:Construction and analysis,6491 Membranelipid physicalstate and modulationof Na+,Mg2+-ATPase Tumorrejection: Suppression by autologousanti-idiotypic immunity, activity in Acholeplasma laidlawii B, 1255 2209 Artery Two tumor antigens and their polypeptides in adenovirus type 10,10-Difluoro-13,14-dehydroprostacyclin: Vascular relaxing activity and 12-infectedand transformedcells, 2274 stability studies, 6846 Antigen,tumor cell Arylamine acetyltransferase (EC 2.3.1.5) Transformation-relatedantigens identifiedby monoclonalantibodies, Retinal rhythms in chicks: Circadian variation in melatonin and 3234 serotonin N-acetyltransferase activity, 4998 Antigen,viral capsid (EC 3.1.6.1) Epstein-Barrvirus genes expressedin differentcell types after Complementationof arylsulfataseA in somatic hybridsof metachromatic microinjectionof viral DNA, 433 leukodystrophyand multiple sulfatasedeficiency disorder fibroblasts, Antiheparin 6166 Humanplatelet basic proteinassociated with antiheparinand mitogenic Ascaris activities:Purification and partialcharacterization, 5914 Bia, a paralyzing anthelmintic that affects interneurons and Antioxidant,dietary inhibitory motoneurons in Ascaris, 6211 Increase of NAD(P)H:quinone reductase by dietary antioxidants: Ascorbic acid Possible role in protectionagainst carcinogenesis and toxicity, 5216 Ascorbic acid inhibits replication and infectivity of avian RNA tumor Antipain virus, 2711 Antipaininhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced Free radicalreduction enhanced by elevated concentrationsof ascorbic transformationand increaseschromosomal aberrations, 6649 acid in avian dystrophic muscle, 790 Inhibition of carcinogen-induced chromosomal aberrations by an A24 semihistone anticarcinogenicprotease inhibitor, 3544 High-resolution fractionation of nucleosomes: Minor particles, "whiskers," and separation of mononucleosomes containing and 3-0-Sulfated D-glucosamineresidue in antithrombin-bindingsequence of lacking A24 semihistone, 3244 ,6551 Aspartate Aphidicolin Receptorstructure in bacterialsensing system, 7157 DNA polymerasea mutants from a Drosophilamelanogaster cell line, Aspartateaminotransferase (EC 2.6.1.1) 7049 Pyridoxal--dependent enzyme, mitochondrial aspartate Aphthovirus aminotransferase: Three-dimensional structure, 2559 Structural polypeptides of aphthovirus are phosphoproteins, 7444 Aspartate carbamoyltransferase (EC 2.1.3.2) Aplysia Communication between catalytic subunits in hybrid aspartate Analysisof mechanismof fast axonal transportby intracellularinjection transcarbamoylase molecules: Effect of ligand binding to active chains of potentiallyinhibitory macromolecules: Possible role of actin on conformation of unliganded, inactive chains, 5187 filaments,7448 Propagation of conformational changes in Ni(II)-substituted aspartate Calciumcurrent modulation underlying presynaptic facilitation and transcarbamoylase: Effect of active-site ligands on regulatory chains, behavioralsensitization in Aplysia: Mechanism,6912 1995 Catalytic subunit of cyclic AMP-dependent protein kinase: Single amino acid substitution mutants of aspartate Microinjectionenhances calcium action potentialsof bag cell neurons carbamoyltransferase:Isolation and preliminarycharacterization, 3249 in cell culture,7487 Stopped-flowx-ray scattering:Dissociation of aspartate Intracellular injection of catalytic subunit of cyclic AMP-dependent transcarbamylase, 4040 protein kinase simulates facilitation of transmitter release underlying Aspartatekinase (EC 2.7.2.4) behavioral sensitization in Aplysia, 7492 Nucleotide sequence of thrA gene of Escherichia coli, 5730 Ionizing radiation: Differential effects on circadian oscillator and other Sequential folding of a bifunctional allosteric protein, 3379 functions in eye of Aplysia,' 5542 Aspartate transcarbamoylase Aplysia californica see Aspartate carbamoyltransferase Presynaptic inhibition in Aplysia involves a decrease in the Ca2+ current AspartokinaseI of the presynaptic , 1185 see Presynapticmembrane potential affects transmitterrelease in an AspartokinaseI-homoserine dehydrogenase I identified neuron in Aplysia by modulating Ca2+ and K+ currents, 629 Sequential folding of a bifunctional allosteric protein, 3379 Quantal release of acetylcholine examined by current fluctuation analysis Aspergillusoryzae at identified neuro-neuronal synapse of Aplysia, 1661 Inverted repeat as a recognizable structural feature in supercoiled DNA Serotonin-induced hyperpolarization of an identified Aplysia neuron is molecules, 6468 mediatedby cyclic AMP, 5013 Aspergillusterreus Two neuroactivepeptides that cause bag cell afterdischargeand Mevinolin:A highly potent competitiveinhibitor of egg-layingin Aplysia: Purificationand primarystructure, 2328 hydroxymethylglutaryl-coenzyme A reductase and a Apolipoprotein -lowering agent, 3957 ApolipoproteinB variantderived from rat intestine, 3806 Aspirin Heterogeneityof apolipoproteinB: Isolationof a new species from Arachidonate metabolism via lipoxygenase and human chylomicrons, 2465 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to Isoprotein specificity in hepatic uptake of apolipoprotein E and anti-inflammatorydrugs, 308 pathogenesisof familialdysbetalipoproteinemia, 4349 Regulationof cyclic AMP formationin brain tissue by a-adrenergic Arabidopsisthaliana receptors: Requisite intermediacy of prostaglandins of the E series, Photorespirationmutants of Arabidopsisthaliana deficient in 3024 serine-glyoxylate aminotransferase activity, 2684' Ataxia-telangiectasia Arachidonicacid Radiosensitivity in ataxia-telangiectasia: A new explanation, 7315 Arachidonate metabolism via lipoxygenase and Atheromatouslesion 12L-hydroperQxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to Low density lipoproteinreceptor activity in human monocyte-derived anti-inflammatorydrugs, 308 macrophagesand its relationto atheromatouslesions, 5466 Arachidonicacid: Role in stimulationof hexose transportby human Atherosclerosis polymorphonuclearleukocytes, 5125 Coronaryatherosclerosis associated with hyperapobetalipoproteinemia Leukotriene D: Slow reacting substance from rat basophilic leukemia [increasedprotein but normalcholesterol levels in humanplasma low cells, 2014 density (,3)lipoproteins], 604 Mouse peritonealmacrophages release leukotrieneC in responseto a Malondialdehydealteration of low density lipoproteinsleads to phagocyticstimulus, 4928 cholesteryl ester accumulation in human monocyte-macrophages, 2214 Neutral protease activation of peritoneal macrophage prostaglandin Platelet-derivedgrowth factor stimulates low density lipoprotein synthesis, 4736 receptoractivity in culturedhuman fibroblasts,5962 PhospholipaseA2 inhibitoryprotein in rabbit neutrophilsinduced by Atomic bomb survivor glucocorticoids,2533 Search for mutations affecting protein structure in children of atomic Prostaglandinsderived from releaseof arachidonoylresidues as a result bomb survivors:Preliminary report, 4221 of phosphatidylinositol breakdown: Evidence for a role in Autoantibody stimulus-secretion coupling, 3292 Autoantibodyto centromere(kinetochore) in sclerodermasera, 1627 Serum stimulation of A2 and prostaglandin release in 3T3 Autoimmunity cells is associatedwith platelet-derivedgrowth-promoting activity, 137 Nucleic acid-specific suppressor T cells, 1593 Arginine Autophagy Camphorquinone-10-sulfonicacid and derivatives:Convenient reagents Protein bodies of mung bean cotyledonsas autophagicorganelles, 428 for reversiblemodification of arginineresidues, 895 Downloaded by guest on September 29, 2021 7548 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Autoradiography DNA sequenceof regulatoryregion for integrationgene of bacteriophage -y-Aminobutyricacid receptors:Autoradiographic localization in rat X, 2477 cerebellum,670 IntegratedMoloney sarcoma proviral DNA sequences:Cloning in Autoradiographicmethod for measuringischemic myocardium at risk: bacteriophageX (correction),1229 Effects of verapamilon infarctsize after experimentalcoronary artery Integrativerecombination of bacteriophageX: Extent of DNA sequence occlusion,6119 involvedin attachmentsite function,3220 Autoradiographyin vitro of opiate receptorsin rat brainsuggests loci of Molecularcloning of unintegratedMoloney mouse sarcomavirus DNA in "opiatergic" pathways, 5532 bacteriophageX, 1773 Differentiationof a- and g-opiate receptorlocalizations by light Novel bacteriophage X cloning vector, 5172 microscopicautoradiography, 6239 Promoterfor establishmentof repressorsynthesis in bacteriophageX, Noradrenergical and a2 receptors:Light microscopicautoradiographic 3191 localization,1696 Protein p3 is linked to DNA of phage (29 througha phosphoesterbond Auxin between serine and 5'-dAMP, 6425 Auxin-inducedchanges in patternsof proteinsynthesis in soybean RNA in D loops of intracellularX DNA, 2153 hypocotyl,357 Site-specific recombination functions of bacteriophage X: DNA sequence Vanadateinhibition of auxin-enhancedH+ secretionand elongationin of regulatory regions and overlapping structural genes for Int and Xis, pea epicotylsand oat coleoptiles,7242 2482 Avena sativa Transformationof Streptococcuspneumoniae with S. pneumoniae-X Abscisicacid content of oat leaves:Changes during senescence, 2050 phage hybridDNA: Inductionof deletions,3534 AvermectinB1l Bacteriophagefl AvermectinBia, a paralyzinganthelmintic that affects interneuronsand Originof DNA replicationof bacteriophagefl as the signal for inhibitorymotoneurons in Ascaris,6211 termination,5226 Avian erythroblastosisvirus Predicting coding function from nucleotide sequence or survival of Cellulargenes: Activation by avian RNA tumor viruses,5351 "fitness"of tRNA, 3539 Comparativetryptic peptide mappingstudies suggest a role in cell BacteriophageM13 transformationfor gag-relatedprotein of avian erythroblastosisvirus DNA strand initiationsequence of ColEl plasmid:Expression in a and avian myelocytomatosisvirus strains CMIIand MC29, 1637 single-strandedDNA phage,6566 Mutant of avian erythroblastosisvirus defective for erythroblast Mechanisms of membrane assembly: Effects of energy poisons on transformation:Deletion in erb portionof p75 suggestsfunction of the conversion of soluble M13 coliphage procoat to membrane-bound coat proteinin leukemogenesis,6683 protein,827 Avian myeloblastosisvirus Plasmid pBR322:Replication under control of a cloned replicationorigin Cellulargenes: Activation by avian RNA tumorviruses, 5351 from single-stranded DNA phage M13, 4638 Cellularsequences are present in presumptiveavian myeloblastosisvirus Procoat, the precursor of M13 coat protein, requires an electrochemical genome,5177 potentialfor- membrane insertion, 4669 GeneticStructure of avian myeloblastosisvirus, releasedfrom BacteriophageMS-2 transformedmyeloblasts as a defectivevirus particle,5120 Antiviral response elicited by a completely synthetic antigen with Native ribonucleoproteinis an efficient transcriptionalcomplex of avian built-in adjuvanticity, 6769 myeloblastosisvirus, 1296 Bacteriophage Mu Proviralgenome associated with avian myeloblasticleukemia, 3004 Bacteriophage Mu: Integration at host chromosomal replication forks RNA primerused in synthesis of anticomplementaryDNA by reverse duringlytic development,2801 transcriptaseof avian myeloblastosisvirus, 1316 Inversionsof specificDNA segmentsin flagellarphase variationof Avian myelocytomatosisvirus Salmonella and inversionsystems of bacteriophagesP1 and Mu, 7338 Comparativetryptic peptide mappingstudies suggest a role in cell Mu-containingplasmids: Association with Escherichiacoli chromosome transformationfor gag-relatedprotein of avian erythroblastosisvirus upon prophageinduction, 1778 and avian myelocytomatosisvirus strains CMIIand MC29, 1637 BacteriophageP1 Inversionsof specificDNA segmentsin flagellarphase variationof Acetylcholinereceptors on myotubes:Crosslinkage and visualizationwith Salmonella and inversionsystems of bacteriophagesP1 and Mu, 7338 biotinylateda-bungarotoxin and fluorescentavidin, 4823 BacteriophageQ,8 Iminobiotinaffinity columnsand their applicationto retrievalof Qf replicase template specificity: Different templates require different ,4666 GTP concentrations for initiation, 2601 Axon Bacteriophage T3 Analysisof mechanismof fast axonaltransport by intracellularinjection 5'-Terminaloligonucleotide fragments of RNA transcriptssynthesized by of potentiallyinhibitory macromolecules: Possible role'of actin bacteriophageT3-induced RNA polymerasefrom T3 DNA: Isolation filaments,7448 and sequencedetermination, 3908 Currentrecorded from a cut-opengiant axon under voltage clamp,7484 BacteriophageT4 Fast axonaltransport in auditoryneurons of guinea pig: A rapidly Aminoacid sequenceof the T4 DNA helix-destabilizingprotein, 4614 turned-overglycoprotein, 3042 Differential amplification of specific areas of phage T4 genome as Fast axonaltransport in presenceof high Ca2+:Evidence that revealedby hybridizationto cloned genetic segments,5064 microtubulesare not required,5909 Pentaribonucleotidesof mixed sequenceare synthesizedand efficiently Azophenylarsonate prime de novo DNA chain starts in T4 bacteriophageDNA replication Hybridomaproteins expressing the predominantidiotype of the system, 5698 antiazophenylarsonateresponse of A/J mice, 1120 BacteriophageT7 Azotobactervinelandii BacteriophageT7 DNA replication:Physical mappingof primaryand Alternativenitrogen fixation system in Azobactervinelandii, 7342 secondaryorigins, 2656 Iron proteinsfrom the nitrogenfixation complexesof Azotobacter Contacts between Escherichia coli RNA and an early vinelandii, Clostridiumpasteurianum, and Klebsiella pneumoniae, promotorof phage T7, 122 3826 Gene-directedmutagenesis in bacteriophageT7 providedby polyalkylatingRNAs complementaryto selected DNA sites, 2796 Baboon Nucleotidesequence of primaryorigin of bacteriphageT7 DNA see Papio papio replications: Relationship to adjacent genes and regulatory elements, Bacillus cereus 3917 Measurementsof pH within dormantand germinatedbacterial spores, Bacteriophage4X174 2474 DNA replication in vitro of recombinant plasmid containing the Bacillus megaterium origin of progeny replicative form DNA synthesis of phage kX174, Measurementsof pH within dormantand germinatedbacterial spores, 5182 2474 Escherichia coli replication protein that recognizes a unique sequence Bacillus subtilis within a hairpinregion in kX174DNA, 799 Biparentalproducts of bacterialprotoplast fusion showingunequal Indiscriminaterecombination in simianvirus 40-infectedmonkey cells, parentalchromosome expression, 3553 4861 DNA-membraneassociation is necessaryfor initiation of chromosomal Replicationof duplex DNA of phage XX174reconstituted with purified and plasmidreplication in Bacillus subtilis, 2834 enzymes, 3322 Novel RNA polymerasea factor from Bacillus subtilis, 7000 Bacteriorhodopsin Posttranscriptionalregulation of an erythromycinresistance protein Bacteriorhodopsinis an inside-outprotein, 5894 specifiedby plasmidpE194, 3903 Chromophore:Location in bacteriorhodopsin,4726 Recognitionof local nucleotideconformation in contrastto sequenceby Delipidationof bacteriorhodopsinand reconstitutionwith exogenous a rRNA processingendonuclease, 5644 phospholipid,323 Bacteriochlorophyll Delipidationof bacteriorhodopsinand reconstitutionwith exogenous Electrontransport: Inhibition by orthophenanthrolinein phopholipid(correction), 2353 chromatophoresand reactioncenters of Rhodopseudomonas Exchangekinetics of Schiff base protonin bacteriorhodopsin,6571 sphaeroides, 1809 Halobacteria:Anaerobic growth, 3821 Pigment-protein complexes of Rhodopseudomonas sphaeroides: Orthorhombic two-dimensional crystal form of purple membrane, 338 Isolation and characterization by lithium dodecyl ' Path of the polypeptide in bacteriorhodopsin, 2023 sulfate/polyacrylamide gel electrophoresis, 87 Surface charge changes in purple membranes and the photoreaction Bacteriophage X cycle of bacteriorhodopsin, 4707 see also Receptor, bacteriophage X Three-dimensional crystals of membrane proteins: Bacteriorhodopsin, Bacteriophage X vehicle for direct cloning of Escherichia coli promoter 1283 DNA sequences: Feedback regulation of rplJL-rpoBC operon, 2124 Bandeiraeasimplicifolia Comparison in vitro of initiation properties of bacteriophage X wild-type Differential lectin binding to cellular membranes in epidermis of PR and x3 mutant promoters, 6381 newborn rats, 477 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7549

Barbiturate Regulationof hexosaminebiosynthetic pathway in water mold Barbiturate receptor sites are coupled to benzodiazepine receptors, 7468 Blastocladiella emersonii: Sensitivity to endproduct inhibition is Base stacking depehdentupon life cycle phase, 5998 Tetramerd(CpGpCpG) crystallizes as a left-handeddouble helix, 4016 Blastocyst Bee Monoclonalantibodies against trophectoderm-specificmarkers during see Lasioglossumzephrum mouse blastocystformation, 4113 Behavior Blood coagulation Brain size and ecologyin small mammalsand primates,4387 see also specific factors Calcium current modulation underlying presynaptic facilitation and Cloning,andanalysis of a cDNA coding for bovine prothrombin,5153 behavioral sensitization in Aplysia: Mechanism, 6912 Fibrinogen:Cleavage by humanneutrophil neutral peptide-generating Enkephalinand fear-motivatedbehavior, 3729 protease,5448 Gene-culturetranslation in avoidanceof sibling incest, 6248 Four different polymerization sites involved in human fibrin formation, Metabolicresource allocation vs. mating attractiveness:Adaptive 1374 pressureson the "alba"polymorphism of Colias butterflies,3615 3-0-Sulfated D-glucosamineresidue in antithrombin-bindingsequence of Rapid taste-aversionlearning by an isolated molluscancentral nervous heparin,6551 system, 6204 Thrombinincreases expression of fibronectinantigen on platelet surface, Resurgenceof respondingafter cessationof response-independent 1049 reinforcement,6251 Blood group Translationof epigeneticrules of individualbehavior into ethnographic see Antigen,blood group patterns, 4382 Blood, peripheral Beneckea harveyi HumanT lymphocytesand their subclasses:Simple and rapid Proteolyticinactivation of luciferasesfrom three species of luminous measurementin peripheralblood, 4914 marinebacteria, Beneckea harveyi,Photobacterium fischeri, and Bluegill sunfish Photobacteriumphosphoreum: Evidence of a conservedstructural see Lepomis macrochirus feature,6363 Bonibesin Benz[a]anthracene,dimethyl- Brain regulationof gastricsecretion: Influence of neuropeptides,5515 Mechanismof action of anti-tumor-promotingagents: Specificity in Bone two-stagepromotion, 2251 Bone resorptionand calciumconservation during D deficiencyor hypervitaminosisD: Direct measurement,1818 Cytogeneticeffects of inhaled benzenein murinebone marrow: Fibronectin: Synthesis and localization during collagenous Induction of sister chromatid exchanges, chromosomal aberrations, matrix-mesenchymalcell interactionand differentiationof cartilage and cellularproliferation inhibition in DBA/2 mice, 2148 and bone in vivo, 2074 Benzodiazepine Radioimmunoassayfor vitamin K-dependentprotein of bone and its see also Receptor,benzodiazepine discoveryin plasma,2234 Repeatedseizures induce long-termincrease in hippocampal Bordetellapertussis benzodiazepinereceptors, 3029 Calmodulinactivates prokaryotic adenylate cyclase, 3841 Urinaryand brainf-carboline-3-carboxylates as potent inhibitorsof Brachydaniorerio brain benzodiazepinereceptors, 2288 Growing optic nerve fibers follow neighbors during embryogenesis, 4374 Benzomiorphan Brain Distinct morphineand enkephalinreceptors: Possible role in mediating see also Cerebellum; Hippocampus; Hypophysis; Hypothalamus; actions of benzomorphandrugs (putative Kand a agonists),4469 Membrane,brain; , central Benzo[a]pyrene Antibodiesspecific to choline acetyltransferase:Preparation from bovine Culturedmouse embryosmetabolize benzo[a]pyrene during early caudatenucleus and immunohistochemicallocalization of the enzyme, gestation:Genetic differencesdetectable by sister chromatidexchange, 7453 3524 Autoradiographyin vitro of opiate receptorsin rat brain suggests loci of Specificity in interaction of benzo[a]pyrene with nuclear "opiatergic"pathways, 5532 macromolecules:Implication of derivativesof two dihydrodiolsin Barbituratereceptor sites are coupledto benzodiazepinereceptors, 7468 protein binding,6396 Benzodiazepinereceptor protein identified and visualizedin braintissue Benzo[alpyrenediol epoxide by photoaffinitylabel, 1666 DNA alkylationand unwindinginduced by benzo[a]pyrenediol epoxide: Bovine adrenal chromaffin cells: Prolonged survival in rat cerebral Modulationby ionic strengthand superhelicity,2000 ventricles, 5278 Error-freeexcision of cytotoxic,mutagenic N2-deoxyguanosine DNA Brain adenylatecyclase: Properties of the separatedcatalytic and adduct formedin humanfibroblasts by regulatory units, 6344 (+)-7/,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, Brain cholecystokinin-convertingenzymes: Further characterization, 5933 3669 Fungaloxidation of (+)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: Brain clathrin:Immunofluorescent patterns in culturedcells and tissues, Formationof diastereomericbenzo[a]pyrene 9,10-diol 7,8-epoxides, 5520 4554 Brain regulationof gastricsecretion: Influence of neuropeptides,5515 Bicuculline Brain size and ecologyin small mammalsand primates,4387 Bicucullineenhances a negativecomponent and diminishesa positive Cholecystokinin-convertingenzymes in brain,597 componentof visual evoked corticalpotential in cats, 7476 Clumpingof acetylcholinesteraseactivity in developingstriatum of Bile humanfetus and young infant, 1214 Phalloidin-inducedcholestasis: Microfilament-mediated change in CyclicAMP accumulationin culturedbrain cells: Regulationby secretin, junctionalcomplex permeability, 2229 vasoactiveintestinal peptide, and somatostatin,6907 Retinoyl B-glucuronide:Characterization as a minormetabolite of Cytochromeoxidase of corticalbarrels: Histochemical changes after retinoicacid in bile, 3230 vibrissalremoval'in neonatal and adult mice, 2333 Biochemicalcycle Distinct cholecystokininreceptors in brain and pancreas,6917 Conventionalassumption of internalequilibrium within the states of a /-Endorphin-likepeptides from bovine brains:Isolation and biochemical cycle: Examination, 205 characterization, 230 Bioluminescence Glucagon-relatedpeptides in rat brain:Identification and localization, see also Chemiluminescence 6229 Crossreactivity between light-emitting systems of distantly related Immunohistochemicallocalization of cholecystokinin-and gastrin-like organisms: Novel type of light-emitting compound, 1394 peptides in brain and hypophysisof rat, 1190 Physical interactionand activity couplingbetween two enzymesinduced Immunoreactive dynorphin in.pituitary and brain, 6207 by immobilizationof one, 249 Immunoreactive renin: Wide distribution in nerve cells of human brain, Proteolyticinactivation of luciferasesfrom three species of luminous 5458 marine , Beneckea harveyi, Photobacterium fischeri, and Impulseactivity of locus ceruleusneurons in awakerats and monkeysis Photobacteriumphosphoreum: Evidence of a conservedstructural a functionof sensorystimulation and arousal,3033 feature,6363 Memoryneuron: Operating characteristics for memorycomponent of a neuroconnectivebrain model, 2305 see also Carboxybiotin Memory neuron: Synapse microchemistry for memory component of a Acetylcholinereceptors on myotubes:Crosslinkage and visualizationwith neuroconnectivebrain model, 3019 biotinylateda-bungarotoxin and fluorescentavidin, 4823 Neuroendocrineregulation of corpusallatum activity in Manducasexta: Carboxybiotintranslocation mechanisms suggested by diffractionstudies Sequentialneurohormonal and nervousinhibition in the last-instar of biotin and its vitamers,333 larva,4407 Iminobiotin.affinity columnsand their applicationto retrievalof Noradrenergical and a2 receptors:Light microscopicautoradiographic streptavidin,4666 localization,1696 Opiate regulationof estradiol-2-hydroxylasein brainsof male rats: Circadianrhythms of melatoninrelease from individualsuperfused Mechanismfor controlof pituitaryhormone secretion, 2574 chickenpineal glands in vitro, 2319 Ornithinedecarboxylase: Induction by renin-freenerve growthfactor, Resourcevariation and structureof British bird communities,4185 4607 BK virus Regulationof cyclic AMP formationin brain tissue by a-adrenergic Integratedand free viral DNA in hamstertumors induced by BK virus, receptors:Requisite intermediacyof prostaglandinsof the E series, 975 3024 Blastocladiella emersonii Regulationof hippocampalglutamate receptors: Involvement of a Endogenouselectrical currents in water mold Blastocladiella emersonii calcium-activatedprotease, 2298 duringgrowth and sporulation,6673 Saxitoxinbinding protein/Na+ gate of mammalianbrain: Molecular characterization, reconstitution, and "transport-specific fractionation", 6884 Downloaded by guest on September 29, 2021 7550 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Synaptic endings and their postsynaptic targets in neostriatum: Synaptic Parathyroidhormone alters collagensynthesis and procollagenmRNA specializations revealed from analysis of serial sections, 6926 levels in fetal rat calvaria,5654 Tyrosineadministration increases striatal dopaminerelease in rats with Phospholipidmethylation, Ca2+ influx, and histaminerelease: partial nigrostriatal lesions, 4305 Stimulationby bridgingof IgE receptorson rat mast cells, 1903 Urinary and brain f-carboline-3-carboxylates as potent inhibitors of Presynaptic inhibition in Aplysia involves a decrease in the Ca2+ current brain benzodiazepine receptors, 2288 of the presynapticneuron, 1185 Brevibacteriumflavum Progesterone induces rapid increase in [Ca2+]inof Xenopus laevis Arogenate (pretyrosine) is an obligatory intermediate of L-tyrosine oocytes, 1534 biosynthesis: Confirmation in a microbial mutant, 1270 Quercetininhibits Ca2+uptake but not Ca2+release by sarcoplasmic a-Bungarotoxin reticulum in skinned muscle fibers, 4435 Acetylcholine receptor site density affects rising phase of miniature Regulationof hippocampalglutamate receptors: Involvement of a endplate currents, 3736 calcium-activatedprotease, 2298 Acetylcholine receptors on myotubes: Crosslinkage and visualization with Release of immunoreactivesomatostatin from hypothalamiccells in biotinylated a-bungarotoxin and fluorescent avidin, 4823 culture:Inhibition of -y-aminobutyricacid, 5552 Denervation increases turnover rate of junctional acetylcholine receptors, Calcium-dependentregulatory protein 2293 see Calmodulin ,B-Bungarotoxin Calmodulin Mitochondriaand sarcoplasmicreticulum as model targets for neurotoxic Activationof braintryptophan hydroxylase by ATP-Mg2+:Dependence and myotoxic A2, 1346 on calmodulin,4688 BUT2(3)-tert-Butyl-4-hydroxyanisole Calcium control of intestinal microvillus cytoskeleton: Implications for Increase of NAD(P)H:quinone reductase by dietary antioxidants: regulation of microfilament organizations, 6458 Possible role in protection against carcinogenesis and toxicity, 5216 Calcium-dependentprotein kinase:Widespread occurrence in various Butterfly tissues and phyla of animalkingdom and comparisonof effects of see Colias phospholipid,calmodulin, and ,7039 Calcium-regulatedphosphorylation in synaptosomalcytosol: Dependence Cadmium on calmodulin, 5812 Cadmium-113 NMR of carbonic anhydrases: Effect of pH, bicarbonate, Calmodulin activates prokaryotic adenylate cyclase, 3841 and cyanide,3269 Calmodulin activation of plant microsomal Ca2+ uptake, 7311 Ligandsubstitution reaction of metallothioneinswith EDTA and Calmodulin from spinach leaves and in vitro translation mixtures: apo-carbonicanhydrase, 6334 Isolationand characterization,1912 Metal clustersin rabbitliver metallothionein:Structure, 7094 Calmodulinlocalization in mammalianspermatozoa, 2772 Mouse metallothionein-I gene: Isolation and characterization, 6511 Calmodulin:Localization in rat tissues, 366 Caenorhabditiselegans Myosinlight chain kinase:Purification from bovine cardiacmuscle, 5852 Mutants altering coordinate synthesis of specific myosins during Similaritiesand dissimilaritiesbetween calmodulin and a nematode muscle development, 852 Chlamydomonasflagellar protein, 4779 Calcitonin Calorimetry see also Ribonucleic acid, messenger, calcitonin Exothermic process associated with in vitro polymerization of brain Calcitonin, a major gill hormone, 6935 tubulin, 4425 Calcitonin: Evidence for important physiological role, 609 Nucleationand kineticsof microtubuleassembly, 7302 Neurotensin production by a line of rat medullary thyroid carcinoma Scanningcalorimetric evidence for a third phase transitionin cells, 3741 phosphatidylcholinebilayers, 5060 Calcium Stability of DNA in nucleosomes,4044 Amiloride inhibits murine erythroleukemia cell differentiation: Evidence Calvaria for a Ca2+ requirement for commitment, 5948 la,25-Dihydroxycholecalciferoland 24,25-dihydroxycholecalciferol:In Bone resorption and calcium conservation during vitamin D deficiency or vitro synthesis by isolated calvarial cells, 5720 hypervitaminosis D: Direct measurement, 1818 Parathyroid hormone alters collagen synthesis and procollagen mRNA Calcitonin,a majorgill hormone,6935 levels in fetal rat calvaria,5654 Calcitonin:Evidence for importantphysiological role, 609 Camphorquinone-10-sulfonicacid Calciumand microtubuledependence for increasedornithine Camphorquinone-10-sulfonicacid and derivatives:Convenient reagents decarboxylaseactivity stimulatedby 3-adrenergicagonists, dibutyryl for reversiblemodification of arginineresidues, 895 cyclic AMP, or serumin a rat astrocytomacell line, 995 Cancer Calciumchannels: Involvement in short-termdesensitization of see also Carcinogen, chemical; Tumor; specific cancers; specific cells muscarinic receptor-mediated cyclic GMP formation in mouse Arrest and metastasis of blood-borne tumor cells are modified by fusion neuroblastoma cells, 6897 of plasma membrane vesicles from highly metastatic cells, 399 Calciumcontrol of intestinal microvilluscytoskeleton: Implications for Chinese hamster cell mutants deficient in dihydrofolate reductase regulationof microfilamentorganizations, 6458 activity: Isolation, 4216 Calciumcurrent modulation underlying presynaptic facilitation and Constitutiveuncoupling of pathwaysof gene expressionthat control behavioral sensitization in Aplysia: Mechanism, 6912 growthand differentiationin myeloidleukemia: Model for originand Calciumdependence of phalloidiri-inducedliver cell death, 1177 progression of malignancy, 6152 Calcium-dependenthormonal regulation of amino acid transportand Generation of human monoclonal antibodies reactive with human cyclic AMP accumulationin rat hepatocytemonolayer cultures, 5953 mammary carcinoma cells, 6841 Calcium-dependentprotein kinase: Widespread occurrence in various Generationof oncogenicmouse type C virus:In vitro selectionof tissues and phyla of animalkingdom and comparisonof effects of carcinoma-inducingvariants, 624 phospholipid,calmodulin, and trifluoperazine,7039 Malignancies of metastatic murine lymphosarcoma cell lines and clones Calcium-regulated phosphorylation in synaptosomal cytosol: Dependence correlate with decreased cell surface display of RNA tumor virus on calmodulin,5812 envelope glycoprotein gp70, 5943 Calcium translocation mechanism in sarcoplasmic reticulum vesicles, Methotrexate polyglutamate synthesis by cultured human breast cancer deducedfrom locationstudies of protein-boundspin labels, 2405 cells, 2919 Calmodulin activation of plant microsomal Ca2+ uptake, 7311 Molecularstructure of anticancerdrug-DNA complex: Daunomycin plus Calmodulinfrom spinachleaves and in vitro translationmixtures: d(CpGpTpApCpG), 7204 Isolationand characterization,1912 Monoclonal antibodies to human estrogen receptor, 5115 Calmodulin: Localization in rat tissues, 366 Protease-activated"prodrugs" for cancerchemotherapy, 2224 Can the binding of Ca2+ to two regulatory sites on troponin C determine Spontaneous cancer and its possible relationship to oxygen metabolism, the steep pCa/tensionrelationship of skeletal muscle?4717 1763 Catalyticsubunit of cyclic AMP-dependentprotein kinase: Capacitation Microinjectionenhances calcium action potentialsof bag cell neurons Mechanism of capacitation: Albumin-mediated changes in plasma in cell culture, 7487 membrane lipids during in vitro incubation of rat sperm cells, 1546 Chargemovements during Na+/Ca2+ exchange in heart sarcolemmal Carassiusauratus vesicles, 6354 Microtubules of cells: Visualization in situ by indirect Cooperativeequilibrium binding of myosin subfragment1 to immunofluorescence, 6657 actin-troponin-tropomyosin complex: Theoretical model, 3186 Carbohydrate Correlationbetween relaxation and automaticityin embryonicheart cell see also Protein, carbohydrate-binding aggregates, 679 Carbohydrate requirement for expression and stability of acetylcholine Fast axonal transport in presence of high Ca2+: Evidence that receptor on surface of embryonic muscle cells in culture, 5263 microtubulesare not required,5909 Carbohydrate-bindingcomponent Generalmethod, employingarsenazo III in liposomes,for study of Carbohydrate-binding component of embryo cell surfaces: calciumionophores: Results with A23187and prostaglandins,1506 Restriction to surface regions capable of cell adhesion, 3460 Inhibition of Ca2+ accumulation in mitogen-activated lymphocytes: Role f3-Carboline-3-carboxylate of membrane-boundplasma lipoproteins, 4764 Urinary and brain ,-carboline-3-carboxylates as potent inhibitors of Insulin and glucose 6-phosphatestimulation of Ca2+uptake by skinned brain benzodiazepine receptors, 2288 muscle fibers; 936 Carbonatedehydratase Light-inducedcalcium release by intact retinal rods, 5557 Ligand substitution reaction of metallothioneins with EDTA and Metabolism of 25-hydroxyvitamin D3 in vitro by isolated rat kidney apo-carbonic anhydrase, 6334 cells, 1537 Carbonatedehydratase (EC 4.2.1.1) Mitochondriaand sarcoplasmicreticulum as model targets for neurotoxic Cadmium-113 NMR of carbonic anhydrases: Effect of pH, bicarbonate, and myotoxicphospholipases A2, 1346 and cyanide,3269 Model for cappingderived from inhibitionof surfacereceptor capping by Mitochondrial carbonic anhydrase, 5562 free fatty acids, 437 Myosin light chain kinase: Purification from bovine cardiac muscle, 5852 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) BiologicalSciences Subject Index 7551

Carbondioxide Cyclic AMP as a negative regulator of hormonally induced lactogenesis Carboxybiotintranslocation mechanisms suggested by diffractionstudies in mouse mammary gland organ culture, 2093 of biotin and its vitamers,333 Caseinkinase Mitochondrialcarbonic anhydrase, 5562 Phosphorylationand dephosphorylationof spectrin from human Carbonicanhydrase erythrocyteghosts underphysiological conditions: Autocatalysis rather see Carbonatedehydratase than reactionwith separatekinase and phosphatase,3264 Carbonmonoxide Cataboliterepression Binding of 02 and CO to hemes and hemoproteins,3171 Catabolite repression in Escherichia coli mutants lacking cyclic AMP Carboxybiotin receptorprotein, 5799 Carboxybiotintranslocation mechanisms suggested by diffractionstudies Catalase(EC 1.11.1.6) of biotin and its vitamers,333 Genetic regulationof catalasedevelopmental program in maize Molecularstructure and intermolecularinteractions of scutellum:Identification of a temporalregulatory gene, 5360 Nl'-methoxycarbonylbiotinmethyl ester: Model for carboxybiotin, Cataract 1260 Cysteineand methionine:Selective oxidationin normaland senile y-Carboxyglutamate cataractous lenses, 1274 Radioimmunoassayfor vitamin K-dependentprotein of bone and its Catecholamine discoveryin plasma,2234 Anti-alprenololanti-idiotypic antibodies bind to 3-adrenergicreceptors CarboxypeptidaseA and modulate catecholamine-sensitive adenylate cyclase, 7385 CarboxypeptidaseA mechanisms,3875 Bovine adrenalchromaffin cells: Prolongedsurvival in rat cerebral CarboxypeptidaseA (EC 3.4.17.1) ventricles,5278 CarboxypeptidaseA, in supercooledwater: Structure and function 132 Catecholaminebiosynthetic enzymes are expressedin replicatingcells of Potato inhibitorcomplex of carboxypeptidaseA: Structureat 5.5-A peripheralbut not central nervoussystem, 6221 resolution,277 Tyrosinehydroxylase: Substrate of cyclic AMP-dependentprotein Potato inhibitorcomplex of carboxypeptidaseA: Structureat 2.5-A kinase,92 resolution,4633 CDP-cholinesynthetase Structureof an actively exchangingcomplex between carboxypeptidase see Cholinephosphatecytidylyltransferase A and a substrateanalogue, 3288 Cel Carcinogen,chemical see also Differentiation,cell; Hybridcell; specific cells see also specific chemicals Cell adhesion Antipaininhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced Adhesionfactor for chondrocytes:Identification, 385 transformationand increaseschromosomal aberrations, 6649 Carbohydrate-bindingcomponent of amphibianembryo cell surfaces: Chemicalcarcinogen-modified DNA recognizedby a DNA-binding Restrictionto surfaceregions capable of cell adhesion,3460 protein,3201 Cell surfacemolecule involved in aggregationof embryonicliver cells, Chemicalcarcinogen-modified DNA recognizedby a DNA-binding 4831 protein(correction), 7510 Cellularadhesion: Role of a 16S glycoproteincomplex, 4137 Conformationof poly(dG-dC).poly(dG-dC)modified by carcinogens Chinesehamster lung cells synthesizeand confine to the cellulardomain N-acetoxy-N-acetyl-2-aminofluoreneand a collagen composed solely of B chains, 5206 N-hydroxy-N-2-aminofluorene,4597 Cytoskeletalproteins vinculin and a-actinin:Altered distributionsin Cycle-relatedtoxicity and transformationin 1OT1/2cells treated with cultured fibroblasts transformed by Rous sarcoma virus, 6687 N-methyl-N'-nitro-N-nitrosoguanidine,4813 Fibronectin:Functional domain structure, 2661 DNA alkylationand unwindinginduced by benzo[a]pyrenediol epoxide: Fibronectin is not present in focal adhesions formed between normal Modulationby ionic strengthand superhelicity,2000 cultured fibroblasts and their substrata, 7318 Enhancementof N-methyl-N'-nitro-N-nitrosoguanidinetransformation Glycosaminoglycans that bind cold-insoluble in cell-substratum of Syrianhamster cells by a phorboldiester is independentof sister adhesionsites of murinefibroblasts, 6662 chromatidexchanges and chromosomeaberrations, 7282 The cbpA gene:Role of the 26,000-daltoncarbohydrate-binding protein Fecalase:A model for activationof dietaryglycosides to mutagensby in intercellular cohesion of developing Dictyostelium discoideum cells, intestinalflora, 4961 4788 Fungaloxidation of (+)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: Thrombinincreases expression of fibronectinantigen on platelet surface, Formationof diastereomericbenzo[a]pyrene 9,10-diol 7,8-epoxides, 1049 4554 Cell, adrenalmedullary chromaffin Geneticallydominant resistance in mice to Bovine adrenalchromaffin cells: Prolongedsurvival in rat cerebral 3-methylcholanthrene-inducedlymphoma, 2960 ventricles,5278 Increaseof NAD(P)H:quinonereductase by dietary antioxidants: Studies with [35S]methionineindicate that the 22,000-dalton Possible role in protectionagainst carcinogenesisand toxicity, 5216 [Met]enkephalin-containingprotein in chromaffincells is a precursor Inhibitionof carcinogen-inducedchromosomal aberrations by an of [Met]enkephalin,6889 anticarcinogenicprotease inhibitor, 3544 Synthesis of enkephalinsby adrenalmedullary chromaffin cells: Mechanismof action of anti-tumor-promotingagents: Specificity in Reserpineincreases incorporation of radiolabeledamino acids, 4364 two-stagepromotion, 2251 Cell, adrenocorticaltumor Mechanismof skin tumor promotion:Evidence for severalstages in Adrenocorticotropichormone increases specific proteins of the promotion,3659 mitochondrial fraction that are translated inside or outside this Moleculargenetics of carcinogenesisin rats: Model, 3450 organellein culturedadrenal tumor cells, 4648 Phorbolester tumor promoters:Specific binding,567 Regulationof ornithinedecarboxylase activity by corticotropinin Specificityin interactionof benzo[a]pyrenewith nuclear adrenocortical tumor cell clones: Roles of cyclic AMP and cyclic macromolecules:Implication of derivativesof two dihydrodiolsin AMP-dependent protein kinase, 2767 proteinbinding, 6396 Cell agglutination Transformationof culturedC3H/10T1/2 mouse embryofibroblasts by Cell-cell recognition in yeast: Purification of Hansenula wingei 21-cell 3-methylcholanthrene:Probabilistic view, 7272 sexual agglutinationfactor and comparisonof factors from three Carcinusmaenas genera, 318 Protein phosphorylationand sodium conductancein nerve membrane, Cell, amphibianembryo 812 Carbohydrate-binding component of amphibian embryo cell surfaces: Cardiaccycle Restriction to surface regions capable of cell adhesion, 3460 Measurementof changesin high-energyphosphates in the cardiaccycle Cell, astrocytoma by using gated 31pnuclear magnetic resonance, 3654 Calciumand microtubuledependence for increasedornithine Cardiacglycoside decarboxylase activity stimulated by ,-adrenergic agonists, dibutyryl Ouabain-binding-sitephotoaffinity probes that label both subunits of cyclic AMP, or serum in a rat astrocytomacell line, 995 Na+,K+-ATPase,4529 Mepacrineblocks /-adrenergic agonist-induced desensitization in Cardioactivefactor astrocytomacells, 1341 Cardioactivefactor in humanplasma with positive inotropicand positive Cell, B chronotropicactivity, 6820 Antibody directed against Friend leukemia virus stimulates DNA Cardiolipin synthesis in subpopulation of mouse B lymphocytes, 1486 Ion-transportchain of cytochromeoxidase: The two chain-direct Cell cycle and differentialexpression of HLA-A,Band HLA-DRantigens couplingprinciple of energycoupling, 6391 on humanB lymphoidcells, 7297 Carotenoid Clonalanergy: Persistence in tolerant mice of antigen-bindingB Pigment-proteincomplexes of Rhodopseudomonassphaeroides: lymphocytesincapable of respondingto antigen or mitogen, 1602 Isolationand characterizationby lithium dodecyl Cloningand partialnucleotide sequence of human immunoglobulin, sulfate/polyacrylamidegel electrophoresis,87 chain cDNA from B cells and mouse-humanhybridomas, 6027 Cartilage Genetic controlof murineIgD structuralheterogeneity, 4256 Adhesionfactor for chondrocytes:Identification, 385 Human soluble suppressor factor affecting lymphocyte responses in Clonal antibodies for core protein of chondroitin sulfate proteoglycan, vitro, 6096 3971 Immunoglobulin C, gene: Expression in mouse T and B lymphoid and Fibronectin:Synthesis and localizationduring collagenous myeloid cell lines, 2876 matrix-mesenchymalcell interactionand' differentiation of cartilage Immunoglobulin heavy chain genes: Rearrangement during and bone in vivo, 2074 B-lymphocytedevelopment as revealedby studies of mouse talpid2 mutant of the chickenwith perturbedcartilage development has plasmacytoma cells, 1422 an altered precartilage-specificchromatin protein, 4828 Polymorphism of human B-cell alloantigens: Evidence for three loci Tumor growth in animals controlled by infusion of an angiogenesis within the HLA system, 6101 inhibitor, 4331 Selective killing of normal or neoplastic B cells by antibodies coupled to Casein A chain of ricin, 5419 see also Gene, casein Downloaded by guest on September 29, 2021 7552 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Successive switching of antibody isotypes expressed within the lines of a Cell, embryonalcarcinoma B-cell clone, 5424 Embryonalcarcinoma cell line F9:Growth and differentiationin defined T-cell-dependent B-cell stimulation is H-2 restricted and antigen media,457 dependent only at the resting B-cell level, 1612 Polyomavirus mutants able to developin embryonalcarcinoma cells: Cell, bag Isolationand characterization,1068 Two neuroactive peptides that cause bag cell afterdischarge and Cell, enucleated egg-laying in Aplysia: Purification and primary structure, 2328 Desensitizationof enucleatedcells to hormonesand role of cytoskeleton Cell bioenergetics in controlof normalhormonal response, 4798 Cell bioenergetics: Noninvasive, nondestructive approaches, 7430 Cell, erythroid Cell, bone marrow Erythroid-potentiatingactivity producedby a humanT-lymphoblast cell Cytogenetic effects of inhaled benzene in murine bone marrow: line, 593 Induction of sister chromatid exchanges, chromosomal aberrations, Membranedifferentiation in humanerythroid cells: Unique profilesof and cellular proliferation inhibition in DBA/2 mice, 2148 cell surfaceglycoproteins expressed in erythroblastsin vitro from Humanbone marrowcells: Long-termculture, 4756 three ontogenicstages, 3474 Potential leukemic cells among bone marrow cells of young AKR/J mice, Proportionof fetal hemoglobinsynthesis decreasesduring erythroid cell 2923 maturation,2757 Structuredvariation in self-renewalcapacity within long-termbone Tumorpromoters enhance myeloid and erythroidcolony formationby marrow cultures, 2927 normalmouse hemopoieticcells, 4152 Cell, Chinese hamster Cell, erythroleukemia Postreplication repair and susceptibility of Chinese hamster cells to Activationof humanf-globin genes from nonerythroidcells by fusion cytotoxic and mutagenic effects of alkylating agents, 6072 with murineerythroleukemia cells, 3435 Cell, Chinese hamster lung P-Adrenergicreceptors: Induction and propertiesduring erythroid Chinese hamster lung cells synthesize and confine to the cellular domain differentiationof Friendleukemic cells, 4065 a collagen composed solely of B chains, 5206 Amilorideinhibits murineerythroleukemia cell differentiation:Evidence Cell, Chinese hamster ovary for a Ca2+requirement for commitment,5948 Animal cell membrane mutants altered in phosphatidylcholine synthesis: Inductionof differentiationof murineerythroleukemia cells by Autoradiographic detection, 5192 aminonucleosideof puromycinand inhibitionof inductionby purines Chinese hamster cell mutants deficient in dihydrofolate reductase and purinederivatives, 2740 activity: Isolation, 4216 Cell, fat Fibronectin: Deposition during reverse transformation of Chinese see also Adipocyte hamster ovary cells by cyclic AMP, 985 Insulin causes translocationof glucosetransport activity to plasma Posttranslational modification of elongation factor 2 in membranefrom an intracellularstorage site, 2542 diphtheria-toxin-resistant mutants of CHO-K1 cells, 1010 Cell, Friend Pseudomonas aeruginosa mutant producing a nontoxic, immunologically see Cell, erythroleukemia crossreactive toxin A protein: Isolation and characterization, 7199 Cell fusion Pyrroline-5-carboxylate synthase activity in mammalian cells, 5221 Activationof human#-globin genes from nonerythroidcells by fusion Cell, colon carcinoma with murineerythroleukemia cells, 3435 Hormonal control of human colon carcinoma cell growth in serum-free Monoclonalantibodies to estrophilin:Probes for study of estrogen medium, 3464 receptors,157 Cell, colorectalcarcinoma Cell, glial Antibody-directed cytotoxic agents: Use of monoclonal antibody to direct Growthof normalhuman glial cells in a defined mediumcontaining action of toxin A chains to colorectal carcinoma cells, 4539 platelet-derivedgrowth factor, 6611 Cell culture Presumptivecommon precursor for neuronaland glial cell lineagesin Method for preparing cultures of central neurons: Cytochemical and mouse hypothalamus,4165 immunochemical studies, 653 Presumptivecommon precursor for neuronaland glial cell lineagesin Method for preparing cultures of central neurons: Cytochemical and mouse hypothalamus(correction), 6941 immunochemical studies (correction), 2353 Cell, granulosa Cell, culturedmammalian Aggregationof luteinizinghormone receptors in granulosacells: Possible Classification of cultured mammalian cells by shape analysis and pattern mechanismof desensitizationto the hormone,3440 recognition, 1516 Degradationprocess: Role in mitogeniceffect of epidermalgrowth factor, Cell, CV-1 1466' Direct transfer of cloned genes from bacteria to mammalian cells, 2163. Differentialprocessing of subunitsof humanchorionic gonadotropin by Cell cycle granulosacells in vivo, 4793 Association of 2-Am DNA plasmid with yeast folded chromosomes, 3144 Macromolecularphotoaffinity labeling of lutropinreceptor on granulosa Cell cycle and differential expression of HLA-A,B and HLA-DR antigens cells, 7167 on human B lymphoid cells, 7297 Cell growth Cell cycle regulation of dihydrofolate reductase mRNA metabolism in see also Anaerobicgrowth; Growth factor mouse fibroblasts, 5140 Active proliferationof Rous sarcomavirus-infected, but not normal, Cell cycle-specific mutagenesis at hypoxanthine chickenheart mesenchymalcells in culturemedium of physiological phosphoribosyltransferase locus in adult rat liver epithelial cells, 7377 composition,6606 Cytoplasmic clock with same period as division cycle in Xenopus , Collagen-hydroxyethylmethacrylatehydrogels: Use for cell growth,2064 462 Controlof growthof estrogen-sensitivecells: Role for a-fetoprotein,2084 Density-dependent stimulation and inhibition of cell growth by agents Correlationof patternsof anchorage-independentgrowth with in vivo that disrupt microtubules, 2748 behaviorof cells from a murinefibrosarcoma, 1039 Differential expression of type I and type II cyclic AMP-dependent Density-dependentstimulation and inhibitionof cell growthby agents protein kinases during cell cycle and cyclic AMP-induced growth that disruptmicrotubules, 2748 arrest, 3445 Differentialexpression of type I and type II cyclic AMP-dependent Go-G1 arrest: Role in inhibition of tumor cell growth by interferon, 1471 protein kinasesduring cell cycle and cyclic AMP-inducedgrowth Lateral diffusion of membrane lipids and proteins during cell cycle of arrest,3445 neuroblastoma cells, 1526 Do plasmaand serumhave differentabilities to promotecell growth? Multienzyme complex for metabolic channeling in mammalian DNA 2726 replication, 3312 Embryonalcarcinoma cell line F9:Growth and differentiationin defined Prevalent deficiency in tumor cells of cycloheximide-induced cycle media, 457 arrest, 4123 Growthin kidney epithelialcells inducedin cultureby Na+, 6654 Selective inhibitor of cell proliferation from normal serum, 423 Growthof normalhuman glial cells in a defined mediumcontaining Sequential addition of platelet factor and plasma to BALB/c 3T3 platelet-derivedgrowth factor, 6611 fibroblast cultures stimulates somatomedin-C binding early in cell Growthof T-lymphomacells in serum-freemedium: Lack of involvement cycle, 6644 of cyclic AMP pathwayin long-termcultures, 5993 Simian virus 40-transformed human fibroblasts: Reversible growth Inabilityof serumfrom abetalipoproteinemicsubjects to stimulate arrest, 7306 proliferationof humansmooth muscle cells and dermalfibroblasts in Subcompartments of G1 phase of cell cycle detected by flow cytometry, vitro, 1511 6696 Inhibitionof biologicalactivity of multiplication-stimulatingactivity by Taxol stabilizes microtubules in mouse fibroblast cells, 1561 bindingto its carrierprotein, 7252 Cell death Isolationof a Chinesehamster fibroblast mutant defective in hexose Protection of cultured renal tubular epithelial cells from anoxic cell transportand aerobicglycolysis: Its use to dissect the malignant swelling and cell death, 5445 phenotype,2698 Cell, dendritic Kidney epithelialcell growthinhibitors: Purification, 5989 Rat dendritic cells function as accessory cells and control production of a Selective inhibitor of cell proliferation from normal serum, 423 soluble factor required for mitogenic responses of T lymphocytes, 5414 Serum factors modify cellular requirement for Ca2+, K+, Mg2+, Cell density phosphate ions, and 2-oxocarboxylic acids for multiplication of normal Cell density determines epithelial migration in culture, 4760 humanfibroblasts, 3417 Cell, dentate granule Serumfactors modify cellularrequirement for Ca2+,K+, Mg2+, Preferential neurotoxicity of colchicine for granule cells of dentate gyrus phosphate ions, and 2-oxocarboxylic acids for multiplication of normal of adult rat, 3047 human fibroblasts (correction), 6254 Cell, differentiation Subcompartments of G1 phase of cell cycle detected by flow cytometry, see Differentiation, cell 6696 Cell, Ehrlichascites tumor Sustained growth in primary culture of normal mammary epithelial cells Noninvasive 31p NMR probes of free Mg2+, MgATP, and MgADP in embedded in collagen gels, 2088 intact Ehrlich ascites tumor cells, 2487 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7553

Vascularendothelial cell Potent stimulation differentiated Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in growth: by ' 3T3 adipocytes, 6007 lymphoblastoid cells, 4251 Cell, heart Human interferon: Spontaneous production, 5938 see also Heart Cell, mammary Correlation between relaxation and automaticity in embryonic heart cell Differentiation of a mammary cell line: Control by lipids, 1551 aggregates, 679 Sustained growth in primary culture of normal mammary epithelial cells Ouabain-resistant hyperpolarization induced by insulin in aggregates of embedded in collagen gels, 2088 embryonic heart cells, 3062 Cell, mast Cell, HeLa Adenylate cyclase and immunologic release of mediators from rat mast Epidermal growth factor-induced down-regulation of receptor does not cells: Agonist and antagonist effects of purine- and ribose-modified occurin HeLa cells grownin defined medium,2735 adenosine analogs, 6800 Multiple forms of H4 histone mRNA in human cells, 1942 Phospholipid methylation, Ca2+ influx, and histamine release: Purification of a factor that restores translation of vesicular stomatitis Stimulation by bridging of IgE receptors on rat mast cells, 1903 virus mRNA in extracts from poliovirus-infected HeLa cells, 770 Cell, MCF-7 Specific RNA-cleaving activities from HeLa cells, 2395 Estradiol-receptor complexes: Enrichment in transcriptionally active Cell, hematopoietic fraction of chromatin from MCF-7 cells, 1291 Helper virus is not required for in vitro erythroid transformation of Cell, medullarythyroid carcinoma hematopoietic cells by Friend virus, 5287 Neurotensin production by a line of rat medullary thyroid carcinoma Tumor promoters enhance myeloid and erythroid colony formation by cells, 3741 normalmouse hemopoieticcells, 4152 Cell, muscle Cell, hepatoma Anchorage-independent muscle cell differentiation, 5297 Chromatinrepeat length correlateswith phenotypicexpression in Do plasma and serum have different abilities to promote cell growth? hepatomacells, their dedifferentiatedvariants, and somatichybrids, 2726 3412 Inability of serum from abetalipoproteinemic subjects to stimulate Unique long-actingantiglucocorticoid in whole and brokencell systems, proliferation of human smooth muscle cells and dermal fibroblasts in 5167 vitro, 1511 Cell, hybrid Myogenesis in vitro: Dependence on a trophic protein present in chicken see Hybrid cell embryo extract, 6922 Cell, hypothalamic Cell, myeloid Release of immunoreactive somatostatin from hypothalamic cells in Transcripts of the immunoglobulin C, gene vary in structure and culture: Inhibition of y-aminobutyric acid, 5552 splicing during lymphoid development, 7400 Cell, interplexiform Tumor promoters enhance myeloid and erythroid colony formation by Interplexiform cell in cat retina: Identification by uptake of normal mouse hemopoietic cells, 4152 y-[H]aminobutyric acid and serial reconstruction,658 Cell, naturalkiller Cell, kidney Natural cytotoxic cells against solid tumors in mice: Blocking of Deoxyribopyrimidine triphosphatase activity specific for cells infected cytotoxicity by D-, 2895 with herpes simplex virus type 1, 1872 Target selectivity of interferon-induced human killer lymphocytes Intermediate filaments from baby hamster kidney (BHK-21) cells: In related to their Fc receptor expression, 3620 vitro assembly (correction), 1721 Cell, neuroblastoma Intermediate filaments of baby hamster kidney (BHK-21) cells and Calcium channels: Involvement in short-term desensitization of bovine epidermal keratinocytes have similar ultrastructures and muscarinic receptor-mediated cyclic GMP formation in mouse subunit domain structures, 4534 neuroblastoma cells, 6897 Isopentenyladenineas a mediatorof mevalonate-regulatedDNA Cluster formation of opiate (enkephalin) receptors in neuroblastoma replication,5842 cells: Differences between agonists and antagonists and possible Mechanism of interferon action: Simian virus 40-specific early relationships to biological functions, 3038 polypeptides synthesized in untreated and interferon-treated monkey Lateral diffusion of membrane lipids and proteins during cell cycle of kidney cells, 2419 neuroblastoma cells, 1526 Metabolism of 25-hydroxyvitamin D3 in vitro by isolated rat kidney Cell, pancreaticacinar cells, 1537 Cholecystokinin: Interaction with specific membrane receptors on Protection of cultured renal tubular epithelial cells from anoxic cell pancreatic acinar cells, 2079 swelling and cell death, 5445 Cell, pheochromocytoma Cell, kidney epithelial Intracellular distribution of nerve growth factor in rat Apical membrane aminopeptidase appears at site of cell-cell contact in pheochromocytoma PC12 cells: Evidence for a perinuclear and cultured kidney epithelial cells, 4132 intranuclear location, 1656 Cell density determines epithelial migration in culture, 4760 Nerve growth factor receptors on PC12 cells: Ligand-induced conversion Growth in kidney epithelial cells induced in culture by Na+, 6654 from low- to high-affinitystates, 4751 Insulin and serum increase number of receptors for vasopressin in a Rat pheochromocytoma cells (PC12) chemically fused and grown in kidney-derived line of cells grown in a defined medium, 5979 culture:Physiological and morphologicalstudies, 1701 Kidney epithelial cell growth inhibitors: Purification, 5989 Cell, photoreceptor Cell, L Cholineaccumulation by photoreceptorcells of rabbit retina, 1671 Correctsplicing of a chickenovalbumin gene transcriptin mouse L cells, Cell, pituitary 740 Epidermalgrowth factor and expressionof specific genes:Effects on Reovirus-induced modification of cap-dependent translation in infected culturedrat pituitarycells are dissociablefrom mitogenicresponse, L cells, 152 394 Cell, leukemia Receptor-mediated internalization of fluorescent gonadotropin-releasing Action of granulocyte-macrophage colony-stimulating factors: Studies hormone by pituitary gonadotropes, 6692 using a human leukemia cell line, 5346 Cell, plasmacytoma Appearance of cytoskeletal components on the surface of leukemia cells Immunoglobulin heavy chain genes: Rearrangement during and of lymphocytes transformed by mitogens and Epstein-Barr virus, B-lymphocyte development as revealed by studies of mouse 4979 plasmacytomacells, 1422 Development of chemotactic responsiveness in myeloid precursor cells: Cell, pluripotentstem Studies with a human leukemia cell line, 3664 Structuredvariation in self-renewalcapacity within long-termbone Differentiation of human promyelocytic leukemia cell line (HL-60): marrow cultures, 2927 Induction by retinoic acid, 2936 Cell proliferation Embryonic-fetalerythroid characteristics of a humanleukemic cell line, Action of granulocyte-macrophage colony-stimulating factors: Studies 3509 using a human leukemia cell line, 5346 In vitro 'y irradiation of leukemic cells in mice, rats, and guinea pigs, Clonal analysis of proliferation and differentiation of paired daughter 7435 cells: Action of granulocyte-macrophage colony-stimulating factor on Mouse fibroblast (type I) and immune (type II) interferons: Pronounced granulocyte-macrophage precursors, 5327 differences in affinity for gangliosides and in antiviral and antigrowth Cell, Purkinje effects on mouse leukemia L-1210R cells, 2528 Electricalinhibition of Purkinjecells in cerebellumof the rat, 6244 Potential leukemic cells among bone marrow cells of young AKR/J mice, Cell, reconstituted 2923 Alternative method for identifying reconstituted cells, 381 Relationship of biosynthesis of slow reacting substance to intracellular Cell, renal sarcoma glutathione concentrations, 6870 Correlationbetween spontaneous metastatic potential, Slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) platelet-aggregatingactivity of cell surfaceextracts, and cell surface cells: Effect of cysteine on SRS profile, 6481 sialylationin 10 metastatic-variantderivatives of a rat renal sarcoma Cell, Leydig cell line, 4336 Hormone-inducedguanyl nucleotide binding and activationof adenylate Cell, Schwann cyclase in Leydig cell, 5837 Schwanncells proliferatebut fail to differentiatein defined medium, Cell, liver epithelial 6902 Cell cycle-specific mutagenesis at hypoxanthine Cell, Sertoli phosphoribosyltransferase locus in adult rat liver epithelial cells, 7377 Androgen-bindingprotein: Localization in proliferatingSertoli cells in Cell, lymphoblastoid culture, 5322 (2'-5')01igo(A)polymerase activity: Elevated levels in human Sertoli cells contain a mitogenic polypeptide, 4774 lymphoblastoidcells treated with glucocorticoids,6506 Cell shape Adenosine kinase-deficient human lymphoblastoid cell line: Resistance Classification of cultured mammalian cells by shape analysis and pattern to effects of deoxyadenosine on growth, S-adenosylhomocysteine recognition,1516 hydrolase inactivation, and dATP accumulation, 4292 Downloaded by guest on September 29, 2021 7554 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Cell, spleen Syngeneic tumor cells can induce alloreactive T killer cells: Biological Allelic formsof f2-microglobulinin mouse,7395 role for transplantation antigens, 5409 Allogeneichemopoietic stem cell transplantationusing mouse spleen T-T hybridomaproduct specifically suppresses tumor immunity,2866 cells fractionatedby lectins:In vitro study of cell fractions,1164 Cell, thyroid Cell, splenic adherent see also Cell, medullary thyroid carcinoma Immunologiceffects of whole-bodyultraviolet irradiation: Selective Hormone-dependent functional epithelial cells from rat thyroids: defect in splenic adherentcell functionin vitro, 2881 Culture, 3455 Cell, Syrian hamster Suspensionculture of separatedfollicles consistingof differentiated Enhancementof N-methyl-N'-nitro-N-nitrosoguanidinetransformation thyroid epithelial cells, 472 of Syrianhamster cells by a phorboldiester is independentof sister Cell, tumor chromatidexchanges and chromosomeaberrations, 7282 see also Antigen, tumor cell; specific cells; specific tumors Cell, T In vivo or in vitro treatmentswith anti-I-J alloantiseraabolish immunity Allogeneichemopoietic stem cell transplantationusing mouse spleen to AKR leukemia,2178 cells fractionatedby lectins:In vitro study of cell fractions,1164 Prevalentdeficiency in tumor cells of cycloheximide-inducedcycle Antibodyhelper and antibodysuppressor human T cells separatedby arrest, 4123 using soybeanagglutinin, 6778 Receptor-mediatedendocytosis of antibody-opsonizedliposomes by Antigen-specificinduction and regulationof antibodysynthesis in tumor cells, 4089 culturesof humanperipheral blood mononuclearcells, 1139 Switching on the macrophage-mediated suppressor mechanism by tumor Cell surfacepolypeptides of murineT-cell clones expressingcytolytic or cells to evade host immune surveillance, 4265 amplifieractivity, 1111 Syngeneic tumor cells can induce alloreactive T killer cells: Biological Discrete stages of humanintrathymic differentiation: Analysis of normal role for transplantation antigens, 5409 thymocytesand leukemiclymphoblasts of T-cell lineage, 1588 Transforming growth factors produced by certain human tumor cells: Duringontogeny, Ia-bearing accessory cells are found early in the Polypeptides that interact with epidermal growth factor receptors, thymus but late in the spleen, 1597 5258 Erythroid-potentiatingactivity producedby a humanT-lymphoblast cell Cellularproliferation line, 593 Cytogenetic effects of inhaled benzene in murine bone marrow: Functionalcharacteristics of humanT-cell subpopulationsdistinguished Induction of sister chromatid exchanges, chromosomal aberrations, by a monoclonalantibody, 1607 and cellular proliferation inhibition in DBA/2 mice, 2148 High molecularweight antigenspresent on humanT cells, 6805 Permissive effect of extracellular matrix on cell proliferation in vitro, HumanT lymphocytesand their subclasses:Simple and rapid 4094 measurementin peripheralblood, 4914 Cellulose ImmunoglobulinC, gene:Expression in mouse T and B lymphoidand Cellulose biogenesis: Polymerization and crystallization are coupled myeloidcell lines, 2876 processes in Acetobacter xylinum, 6678 In vivo or in vitro treatmentswith anti-I-J alloantiseraabolish immunity Cell, vascularendothelial to AKR leukemia,2178 Vascular endothelial cell growth: Potent stimulation by differentiated Isolationand partialchemical characterization of IgG Fc receptorof 3T3 adipocytes, 6007 humanT lymphocytesand productionof an antiserum,3645 Cell, Vero Monoclonalantibody that defines an immunoregulatoryT cell subset for Vero cells injected with adenovirus type 2 mRNA produce authentic immunoglobulinsynthesis in humans:Characterization, 2914 viral polypeptide patterns: Early mRNA promotes growth of MurineT cell Ia antigens:Specificity Iat.46 maps in I-J to I-E adenovirus-associated virus, 931 chromosomalsegment of H-2 complex,6783 Vero cells injected with adenovirus type 2 mRNA produce authentic Phorbolesters induce differentiationin humanmalignant T viral polypeptide patterns: Early mRNA promotes growth of lymphoblasts,2964 adenovirus-associated virus (correction), 3070 Rat dendriticcells functionas accessorycells and controlproduction of a Cell wall soluble factorrequired for mitogenicresponses of T lymphocytes,5414 Cellular and molecular basis of increased splenic hemopoiesis in mice Serumthymic factor (FTS): Specific receptorsin lymphoblastoid treated with bacterial cell wall components, 4322 culturedcell lines, 2861 Cellular division in Escherichia coli: Isolation and characterization of Surfacecomponent of primatethymus-derived lymphocytes related to a penicillin-binding proteins 1A, 1B, and 3, 4499 heavy chain variableregion, 3625 Cell wall appositions and plant disease resistance: Acoustic microscopy T-cell-dependentB-cell stimulationis H-2 restrictedand antigen of papillae that block fungal ingress, 2046 dependentonly at the restingB-cell level, 1612 Vanadate inhibition of auxin-enhanced H+ secretion and elongation in T-cell lines establishedfrom humanT-lymphocytic neoplasias by direct pea epicotyls and oat coleoptiles, 7242 responseto T-cell growthfactor, 6815 Centromere T lymphocytecholinergic receptors: Electrophysiology, 4317 Autoantibody to centromere (kinetochore) in scleroderma sera, 1627 Tumorrejection: Suppression by autologousanti-idiotypic immunity, Centromere-linked CDC10 gene: Isolation by complementation in yeast, 2209 2173 Type C retrovirusparticles: Detection and isolationfrom fresh and Centruroidessculpturatus culturedlymphocytes of a patient with cutaneousT-cell lymphoma, Three-dimensional structure of a protein from scorpion venom: New 7415 structural class of neurotoxins, 6496 Cell, 3T3 Cerebellum Colchicineinhibits epidermalgrowth factor degradationin 3T3 cells, 480 -y-Aminobutyric acid receptors: Autoradiographic localization in rat Cytoplasmictransfer of DNA containingsimian virus 40 sequencesinto cerebellum,670 mouse 3T3 cells, 2844 Cyclic GMP-dependent protein kinase and substrate: Localization in Serumstimulation of phospholipaseA2 and prostaglandinrelease in 3T3 mammalian cerebellum, 5537 cells is associatedwith platelet-derivedgrowth-promoting activity, 137 Electrical inhibition of Purkinje cells in cerebellum of the rat, 6244 Cell, 3T6 Cerebrospinalfluid Membranepermeability: Control by externaland internalATP in 3T6 f-Endorphin: Stability, clearance behavior, and entry into the central cells grownin serum-freemedium, 2103 nervous system after intravenous injection of the tritiated peptide in Cell, taste receptor rats and rabbits, 4588 Sodiumand potassiumsalt stimulationof taste receptorcells: Allosteric Cetiedil model, 1686 Effect of cetiedil on erythrocyte sickling: New type of antisickling agent Cell, T, cytotoxic that may affect erythrocyte membranes, 2955 see also Cytotoxicity Chagasdisease Alloantigen-inducedT-cell proliferation:Lyt phenotypeof responding Trypanosoma cruzi: Strains and clones can be characterized by pattern cells and blockingof proliferationby Lyt antisera,2890 of restriction products of kinetoplast DNA minicircles, Allospecificlong-term human cytolytic T-cell lines: Developmentand 6810 characterization,5432 Chara australis Antigen-liposomemodification of target cells as a method to alter their Fluorescence staining of actin cytoskeleton in living cells with susceptibilityto lysis by cytotoxicT lymphocytes,6105 7-nitrobenz-2-oxa-1,3-diazole-phallacidin, 980 Cell surfacepolypeptides of murineT-cell clones expressingcytolytic or Fluorescence staining of actin cytoskeleton in living cells with amplifieractivity, 1111 7-nitrobenz-2-oxa-1,3-diazole-phallacidin (correction), 3747 Cellularinteractions in generationof cytolytic T lymphocyteresponses: Charcot-Leydencrystal Role of Ia-positivesplenic adherentcells in presentationof H-2 Human eosinophil identified as constituent of antigen,6091 Charcot-Leyden crystals, 7440 HLA antigen-relatedrestriction of T lymphocytecytotoxicity to Chemiluminescence Epstein-Barrvirus, 4247 see also Bioluminescence H-2 restrictionas a consequenceof intentionalpriming: T cells of fully Organ chemiluminescence: Noninvasive for oxidative radical allogeneic chimeric mice and of normal mice respond to foreign reactions, 347 antigens in context of H-2 determinants not encountered on thymic Chemotaxis epithelialcells, 7390 Arachidonic acid: Role in stimulation of hexose transport by human H-2 restriction: Independent recognition of H-2 and foreign antigen by a polymorphonuclear leukocytes, 5125 single receptor, 2192 Attractantsand repellentscontrol demethylation of methylated Inheritance of acquired immunological tolerance to foreign chemotaxis proteins in Escherichia coli (correction), 2353 histocompatibilty antigens in mice, 2871 CyclicGMP: Involvement in intracellularsignaling in chemotactic Inheritance of acquired immunological tolerance to foreign response of Escherichia coli, 3879 histocompatibility antigens in mice (correction), 4390 Development of chemotactic responsiveness in myeloid precursor cells: Nucleic acid-specific suppressor T cells, 1593 Studies with a humanleukemia cell line, 3664 Switching on the macrophage-mediated suppressor mechanism by tumor Free radicalsand inflammation:Superoxide-dependent activation of a cells to evade host immune surveillance, 4265 neutrophil chemotactic factor in plasma, 1159 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7555

Humanpolymorphonuclear leukocyte chemotaxis inhibited by Cholesterol oxygenated sterol compounds, 4313 Compositionaldomain structure in phosphatidylcholine-cholesteroland Multiple methylation in processing of sensory signals during bacterial sphingomyelin-cholesterolbilayers, 4055 chemotaxis, 2429 Coronaryatherosclerosis associated with hyperapobetalipoproteinemia Overlapping genes at cheA locus of Escherichia coli, 5370 [increasedprotein but normalcholesterol levels in humanplasma low inhibitory protein in rabbit neutrophils induced by density (,/) lipoproteins],604 glucocorticoids, 2533 Hepatic uptake and degradationof unilamellar Phospholipid methylation during chemotaxis in Dictyostelium sphingomyelin/cholesterolliposomes: A kinetic study, 4030 discoideum:Regulation by guanosine3',5'-cyclic monophosphate, 6996 Heterogeneityof humanhigh density lipoprotein:Presence of Receptor structure in bacterial sensing system, 7157 lipoproteinswith and without apoE and their roles as substratesfor Structuralstudies of methyl-acceptingchemotaxis proteins of lecithin:cholesterol.acyltransferasereaction, 2969 Escherichia coli: Multiple methylation sites, 2434 Humanpolymorphonuclear leukocyte chemotaxis inhibited by Subpopulation of cultured human promyelocytic leukemia cells (HL-60) oxygenatedsterol compounds,4313 displays the formyl peptide chemotactic receptor, 1000 Lecithin:cholesterolacyltransferase: Activation by a synthetic model Transepithelial migration of human neutrophils: An in vitro model lipid- associatingpeptide, 3154 system, 4069 Lipid fluidity markedlymodulates binding of serotoninto mouse brain Transepithelial migration of human neutrophils: An in vitro model membranes,7463 system (correction), 6941 Low density lipoproteinreceptor activity in human monocyte-derived Chemotherapy macrophagesand its relationto atheromatouslesions, 5466 Acyclovir inhibition of Epstein-Barr virus replication, 5163 Metabolismof native and of lactosylatedhuman low density lipoprotein: Antibody-directed cytotoxic agents: Use of monoclonal antibody to direct Evidencefor two pathwaysfor catabolismof exogenousproteins in rat action of toxin A chains to colorectal carcinoma cells, 4539 hepatocytes,5923 Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent Mevinolin:A highly potent competitiveinhibitor of cell-type-specific toxin, 5483 hydroxymethylglutaryl-coenzymeA reductase and a -mediated toxicity of deoxyadenosine analogs cholesterol-loweringagent, 3957 toward malignant human lymphoblasts in vitro and toward murine Platelet-derivedgrowth factor stimulateslow density lipoprotein L1210 leukemia in vivo, 6865 receptoractivity in culturedhuman fibroblasts, 5962 5-Fluorouracil-methotrexate synergy: Enhancement of Regulationof rat liver 3-hydroxy-3-methylglutaryl-coenzymeA reductase 5-fluorodeoxyuridylate binding to thymidylate synthase by in vivo:Enzyme phosphorylation as an early regulatoryresponse after dihydropteroylpolyglutamates, 5663 intragastricadministration of mevalonolactone,6429 Improving the anti-tumor activity of 5-fluorouracil by increasing its (R)-Mevalonateexcretion in human and rat.urines,5738 incorporation into RNA via metabolic modulation, 4966 Somaticcell genetic analysis of regulationof expressionof Indicator sequence of human DNA used to study DNA damage by 3-hydroxy-3-methylglutarylcoenzyme A reductase,6621 methylbis(2-chloroethyl)amine, 6546 Cholesterolesterase (EC 3.1.1.13) Receptor-mediated endocytosis of antibody-opsonized liposomes by Adrenocorticalresponse to corticotropinis potentiatedby part of tumor cells, 4089 amino-terminalregion of pro-corticotropin/endorphin,2239 Chitin Cholesterol,tritiated Regulation of hexosamine biosynthetic pathway in water mold Unreliabilityof tritiated cholesterol:Studies with [1,2-3H]cholesteroland Blastocladiella emersonii: Sensitivity to endproduct inhibition is [24,25-3H]cholesterol in humans,2255 dependent upon life cycle phase, 5998 Cholesterylester Chlamydomonasreinhardtii Malondialdehydealteration of low density lipoproteinsleads to Inheritanceof chloroplastDNA in Chlamydomonasreinhardtii, 6067 cholesterylester accumulationin humanmonocyte-macrophages, 2214 Inheritance of chloroplast DNA in Chlamydomonas reinhardtii Choline (correction), 7510 Cholineaccumulation by photoreceptorcells of rabbit retina, 1671 Similarities and dissimilarities between calmodulin and a Erythrocytecholine concentrationsare elevated in manic patients, 6144 Chlamydomonas flagellar protein, 4779 Uptake of free choline by isolated perfusedrat liver, 4417 Chloramine-T Cholineacetyltransferase (EC 2.3.1.6) Proteins iodinated by chloramine-T method appear to be degraded at an Antibodiesspecific to choline acetyltransferase:Preparation from bovine abnormallyrapid rate after endocytosis,1556 caudatenucleus and immunohistochemicallocalization of the enzyme, Chloramphenicolacetyltransferase (EC 2.3.1.28) 7453 Functional expression in yeast of Escherichia coli plasmid gene coding Cholinephosphatecytidylytransferase (EC 2.7.7.15) for chloramphenicol acetyltransferase, 1078 Animalcell membranemutants altered in phosphatidylcholinesynthesis: Chloride Autoradiographicdetection, 5192 Chloride-activated passive potassium transport in human erythrocytes, Chondrocyte 1711 Adhesionfactor for chondrocytes:Identification, 385 Chlorophyll Chondrocytescontain a growthfactor that is localizedin nucleus and is see also Bacteriochlorophyll associatedwith chromatin,2762 Magnetic field-induced increase in chlorophyll a delayed fluorescence of Polyamineand differentiation:Induction of ornithinedecarboxylase by photosystem II: A 100- to 200-ns component between 4.2 and 300 K, parathyroidhormone is a good markerof differentiatedchondrocytes, 5889 1481 Chlorophylla/b protein Chondrogenesis, Supramolecular structure of stacked and unstacked regions of talpid2mutant of the chickenwith perturbedcartilage development has photosynthetic membranes of Prochloron sp., a prokaryote, 352 an altered precartilage-specificchromatin protein, 4828 Chloroplast Chondroitinsulfate proteoglycan see also Deoxyribonucleic acid, chloroplast Clonalantibodies for core protein of chondroitinsulfate proteoglycan, Chloroplast phosphoproteins: Regulation of excitation energy transfer by 3971 phosphorylation of thylakoid membrane polypeptides, 5253 Choriogonadotropin Interaction between the intermediary electron acceptor (pheophytin) and Aggregationof luteinizinghormone receptors in granulosacells: Possible a possible plastoquinone-iron complex in photosystem II reaction mechanismof desensitizationto the hormone,3440 centers, 7227 Differentialprocessing of subunits of human chorionicgonadotropin by Proton-translocating adenosinetriphosphatase complex from granulosacells in vivo, 4793 chloroplasts: Biosynthesis and assembly, 1361 Hormone-inducedguanyl nucleotidebinding and activationof adenylate Sizes, locations, and directions of transcription of two genes on a cloned cyclase in Leydigcell, 5837 maize chloroplast DNA sequence, 1832 Macromolecularphotoaffinity labeling of lutropinreceptor on granulosa Stoichiometry of system I and system II reaction centers and of cells, 7167 plastoquinone in different photosynthetic membranes, 4712 Chorionicgonadotropin Triplet states in photosystem I of spinach chloroplasts and see Choriogonadotropin subchloroplastparticles (correction),1229 Chromatin Chloroquine see also Heterochromatin Lysomotropic amines cause intracellular accumulation of receptors for Aggregationof small oligonucleosomalchains into 300-A globular epidermal growth factor, 3283 particles,6443 Chondrocytescontain a growthfactor that is localizedin nucleus and is Charge movements during Na+/Ca2+ exchange in heart sarcolemmal associatedwith chromatin,2762 vesicles, 6354 Chromatinrepeat length correlateswith phenotypicexpression in Cholecystokinin hepatomacells, their dedifferentiatedvariants, and somatic hybrids, Cholecystokinin-converting enzymes in brain, 597 3412 Cholecystokinin: Interaction with specific membrane receptors on Chromatinrepeat length in somatic hybrids,2716 pancreaticacinar cells, 2079 Composition of native and reconstituted chromatin particles: Direct Distinct cholecystokinin receptors in brain and pancreas, 6917 mass determination by scanning transmission electron microscopy, Immunohistochemical localization of cholecystokinin- and gastrin-like 4818 peptides in brain and hypophysis of rat, 1190 I-sensitive structure reconstituted on active genes, Cholecystokinin-convertingenzyme 1787 Brain cholecystokinin-converting enzymes: Further characterization, Estradiol-receptor complexes: Enrichment in transcriptionally active 3669 fraction of chromatin from MCF-7 cells, 1291 Choleragen Isolation of newly replicated chromatin by using shallow metrizamide see Toxin, cholera gradients, 3336 Cholestasis Limited DNase I nicking as a probe of gene conformation, 1907 Phalloidin-induced cholestasis: Microfilament-mediated change in Pitch of chromatin DNA is reflected in its nucleotide sequence, 3816 junctional complex permeability, 2229 Points of contact between histone H1 and histone octamer, 127 Downloaded by guest on September 29, 2021 7556 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Reversible dissociation of linker histone from chromatin with Genes codingfor sensitivityto interferon(IfRec) and soluble superoxide preservation of internucleosomal repeat, 885 dismutase(SOD-1) are linked in mouse and man and map to mouse Stability of DNA in nucleosomes, 4044 chromosome16, 2168 Structurally unique basic protein coextracted with histones from calf Linkageanalyses of murineimmunoglobulin heavy chain and serum thymus chromatin,1389 prealbumingenes establishtheir locationon chromosome12 proximal talpid2 mutant of the chicken with perturbed cartilage development has to the T(5;12)31Hbreakpoint in band 12F1,550 an altered precartilage-specificchromatin protein, 4828 Simultaneousexpression of mouse immunoglobulinsM and D is Transcriptionunits of chicken ovalbumingenes observedafter injection determinedby the same homologof chromosome12, 6793 of cloned completegenes into Xenopus oocyte nuclei, 5984 Unequalcrossing over within mouse Tit complex,6077 Chromatography,affinity Chromosome,Robertsonian translocation Affinity chromatography in nonionic detergent solutions, 5847 Genes codingfor sensitivityto interferon(IfRec) and solublesuperoxide Crystallization of part of the miotchondrial electron transfer chain: dismutase(SOD-1) are linked in mouse and man and map to mouse Cytochrome c oxidase-cytochrome c complex, 928 chromosome16, 2168 Dihydrofolate reductase:thymidylate synthase, a bifunctional Chromosome,X poly-peptidefrom Crithidiafasciculata, 5802 InactiveX chromosomeDNA does not functionin DNA-mediatedcell Diphtheriatoxin: Nucleotidebinding and toxin heterogeneity,267 transformationfor the hypoxanthinephosphoribosyltransferase gene, Four different polymerization sites involved in human fibrin formation, 4895 1374 Chromosome,yeast Glycosaminoglycans that bind cold-insoluble globulin in cell-substratum Associationof 2-,m DNA plasmidwith yeast folded chromosomes,3144 adhesion sites of murine fibroblasts, 6662 Chylomicron Iminobiotin affinity columns and their application to retrieval of ApolipoproteinB variantderived from rat intestine, 3806 streptavidin,4666 Heterogeneityof apolipoproteinB: Isolationof a new species from Immunological identification of high molecular weight forms common to humanchylomicrons, 2465 bovine neurophysinand vasopressin,2587 Circadianrhythm Monoclonal antibodies to human estrogen receptor, 5115 Circadianrhythm mutations in Drosophilamelanogaster affect Chromatography,high-pressure liquid short-termfluctuations in male's courtshipsong, 6729 Enkephalin biosynthetic pathway: Proteins of 8000 and 14,000 daltons in Circadianrhythms of melatoninrelease from individualsuperfused bovine adrenalmedulla, 5018 chickenpineal glandsin vitro, 2319 Fungaloxidation of (+)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: Developmentof circadianrhythmicity and light responsivenessin the rat Formationof diastereomericbenzo[a]pyrene 9,10-diol 7,8-epoxides, suprachiasmaticnucleus: A study using the 2-deoxy[i-14C]glucose 4554 method, 1204 High-performanceliquid chromatographytechnique for resolving Ionizingradiation: Differential effects on circadianoscillator and other multipleforms of hepatic membrane-boundcytochrome P-450, 6473 functionsin eye of Aplysia, 5542 Peptide retentiontimes in high-pressureliquid chromatography Retinal rhythmsin chicks:Circadian variation in melatoninand predictedon basis of amino acid composition,1632 serotoninN-acetyltransferase activity, 4998 Retinoyl /-glucuronide:Characterization as a minormetabolite of Circulardichroism retinoicacid in bile, 3230 Aminoacid side chain conformationin angiotensinII and analogs: Chromatography,ion exchange Correlatedresults of circulardichroism and 1H nuclearmagnetic Isovaleryl-CoAdehydrogenase: Demonstration in rat liver mitochondria resonance,82 by ion-exchangechromatography and isoelectricfocusing, 2646 Circulardichroism of adenosinederivatives constrained in the syn form': Chromatophore . Calculations,3398 see also Membrane,chromatophore Conformationof poly(dG-dC)'poly(dG-dC)modified by carcinogens Electrontransport: Inhibition by orthophenanthrolinein N-acetoxy-N-acetyl--2-aminofluoreneand chromatophoresand reactioncenters of Rhodopseudomonas N-hydroxy-N-2-aminofluorene,4597 sphaeroides,1809 Cyanobacterialphycobilisomes: Selective dissociationmonitored by Chromosome fluorescenceand circulardichroism, 1961 see also Sister chromatidexchange Hepatic asialoglycoproteinreceptor: Reconstitution with phospholipid Ecdysteronelocalized on polytene chromosomesof Drosophila vesicles,5087 melanogaster,2108 Citrate(si)-synthase (EC 4.3.3.7) Four heat shock proteins of Drosophila melanogaster coded within a Mineralocorticoidtarget sites: Identificationin isolated rabbitcortical 12-kilobase region in chromosome subdivision'67B, 5390 nephron,3672 Immunoreactive helix-destabilizing protein localized in transcriptionally Clathrin active regionsof Drosophilapolytene chromosomes,6749 Brain clathrin:Immunofluorescent patterns in culturedcells and tissues, Inhibitionof carcinogen-inducedchromosomal aberrations by an 5520 anticarcinogenicprotease inhibitor, 3544 Clostridiumpasteurianum Molecularanalysis of a gene in a developmentallyregulated puff of Iron proteinsfrom the nitrogenfixation complexesof Azotobacter Drosophilamelanogaster, 7362 vinelandii, Clostridiumpasteurianum, and Klebsiellapneumoniae, Molecular limits on size of a genetic locus in Drosophila melanogaster, 3826- 7367 Clostridiumsticklandii Relationships among chromatid interchanges, sister chromatid Selenium-containingtRNAs from Clostridiumsticklandii: exchanges, and meiotic recombination in Drosophila melanogaster, Cochromatographyof one species with L-prolyl-tRNA,1403 1575 Clostripain(EC 3.4.22.8) Selection for viabilityat loci controllingprotein polymorphisms in Globindomains: Heme bindingto centralexon product,1384 Drosophilamelanogaster is very weak at most, 4857 Globindomains: Heme bindingto centralexon product(correction), Site specificity of mutations arising in dysgenic hybrids of Drosophila 3747 melanogaster,6042 CMP-N-acetylneuraminate-galactosylglycoproteinsialyltransferase (EC Chromosome,human 2.4.99.1) Autoantibodyto centromere(kinetochore) in sclerodermasera, 1627 Sendai virus utilizes specific sialyloligosaccharidesas host cell receptor Autosomaldominant aniridia: Probable linkage to acid phosphatase-1 determinants,5693 locus on chromosome 2, 1580 Cnemidophorus DNA segments' from specific human chromosomes: Isolation and "Sexual"behavior in parthenogeneticlizards (Cnemidophorus), 499 localization,2829 Cobalamin Expressionof an X-linked gene from an inactivehuman X chromosome Cobalaminanalogues in animaltissues, 817 in mouse-humanhybrid cells: Noninactivationof the steroid Codon locus in man, 6759 Codonrecognition rules in yeast mitochondria,3167 Geneticanalysis of epidermalgrowth factor action: Assignment of Differentpattern of codon recognitionby mammalianmitochondrial humanepidermal growth factor receptorgene to chromosome7, 4188 tRNAs, 3164 Geneticexchanges among ribosomal genes on nonhomologous Geneticcode and codon readingpatterns in Neurosporacrassa chromosomesin man and apes: Molecularevidence,. 7323 mitochondria:Novel featuresbased on sequencesof six mitochondrial Genetic manipulationby means of microcell-mediatedtransfer of normal tRNAs, 3159 humanchromosomes into recipientmouse cells, 5394 Minimizationof chemicaldistances between amino acids:Role in Highly polymorphiclocus in humanDNA, 6754 evolutionof the genetic code, 1083 Localizationof loci for hypoxanthinephosphoribosyltransferase and Coenzyme glucose-6-phosphate dehydrogenase and biochemical evidence of see also specific coenzymes nonrandom X chromosome expression from studies of a human Mechanismof negativecooperativity in glyceraldehyde-3-phosphate X-autosome translocation,2810 dehydrogenasededuced from ligand competitionexperiments, 5055 Somatic cell genetics of adenosine deaminase expression and severe Molecularstructure and intermolecularinteractions of combinedimmunodeficiency disease in humans,4211 Nl'-methoxycarbonylbiotinmethyl ester:Model for carboxybiotin, Chromosome loss 1260 Immunoglobulin chain loss in hybridoma lines, 2197 CoenzymeA Chromosome,maize Regulation of acetyl-CoA carboxylase: Properties of CoA activation of Asynchronous replication of heterochromatin in maize, 6705 acetyl-CoA carboxylase, 3351 Chromosome,mouse Colchicine Comparativegene mapping:Order of loci on X chromosomeis different Colchicineinhibits epidermalgrowth factor degradationin 3T3 cells, 480 in mice and humans, 3595 Colchicine-sensitive uptake system in Morris hepatomas, 5282 Cytogeneticeffects of inhaled benzenein murinebone marrow: Density-dependentstimulation and inhibitionof cell growthby agents Inductionof sister chromatidexchanges, chromosomal aberrations, that disrupt microtubules, 2748 and cellularproliferation inhibition in DBA/2 mice, 2148 Mitochondria: Localization in living cells with rhodamine 123, 990 Downloaded by guest on September 29, 2021 Proc. 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Preferential neurotoxicity of colchicine for granule cells of dentate gyrus Plasmid ColEl: Sequence-specific recombination, 6724 of adult rat, 3047 Regulatory region of gene for ompA protein, a major outer membrane Colias protein of Escherichiacoli, 3845 Metabolic resource allocation vs. mating attractiveness: Adaptive Cooperativity . pressures on the "alba" polymorphism of Colias butterflies, 3615 Communication between catalytic subunits in hybrid aspartate Collagen transcarbamoylasemolecules: Effect of ligand binding to active chains see also Gene, collagen on conformation of unliganded, inactive chains, 5187 Adhesionfactor for chondrocytes:Identification, 385 Cooperative binding of.myosin subfragment I to Ascorbicacid inhibits replicationand infectivity of avian RNA tumor actin-troponin-tropomyosincomplex, 2616 virus, 2711 Cooperative binding of subfragment 1 to regulated actin: Kinetic studies, Chinese hamster lung cells synthesize and confine to the cellular domain 7209 a collagen composed solely of B chains, 5206 Cooperative equilibrium binding of myosin subfragment 1 to Collagen-tailed and hydrophobic components of acetylcholinesterase in actin-,troponin-tropomyosin complex: Theoretical model, 3186 Torpedo marmorata electric organ, 4464 Energy relay: A proofreading scheme based on dynamic cooperativity Parathyroid hormone alters collagen synthesis and procollagen mRNA and lackingall characteristicsymptoms of kinetic proofreadingin levels in fetal rat calvaria, 5654 DNA replicationand protein synthesis, 5248 Regulation of production of secretory proteins: Intracellular degradation Escherichiacoli L-arabinoseoperon: Binding sites of regulatoryproteins of newly synthesized "defective" collagen, 4746 and a mechanismof positive and negativeregulation, 3346 Structuralbasis for apparentheterogeneity of collagensin human Interchaindisulfide bond: Effect on hapten bindingproperties of light basement membranes: Type IV procollagen contains two distinct .chain dimer of protein 315 (correction), 1229 chains, 745 Positive cooperativity in a (dissected) lectin-membrane glycoprotein Sustained growth in primary culture of normal mammary epithelial cells bindingevent, 3788 embedded in collagen gels, 2088 Propagation of conformational changes in Ni(II)-substituted aspartate Thermal stability of type I and type III procollagens from normal human transcarbamoylase:Effect of active-siteligands on regulatorychains, fibroblasts and from a patient with osteogenesis imperfecta, 162 1995. Collagenase Cooperativity,negative Regulation of stromal cell collagenase production in.adult rabbit cornea: Hormone-receptor interactions are noncooperative: Application to In vitro stimulationand inhibitionby epithelial cell products,5331 /-adrenergicreceptor, 4340 Collagen-hydroxyethylmethacrylatehydrogel Mechanismof negative cooperativityin glyceraldehyde-3-phosphate Collagen-hydroxyethylmethacrylatehydrogels: Use for cell growth,2064 dehydrogenasededuced from ligand competitionexperiments, 5055 Communitystructure Regulationof insulin bindingto isolated hepatocytes:Correction for Resource variation and structure of British bird communities, 4185 bound hormonefragments linearizes Scatchard plots, 3176 Compactin Subunit neighborinteractions in :Half-of-the-sites Isopentenyladenine as a mediator of mevalonate-regulated DNA reactivityin a dimer, 5741 replication, 5842 Copper Mevinolin: A highly potent competitive inhibitor of Carbonmonoxide hemocyanins: Luminescence, 2387 hydroxymethylglutaryl-coenzyme A reductase and a Copperelectron-nuclear double resonanceof cytochromec oxidase, 1452 cholesterol-lowering agent, 3957 Electronparamagnetic resonance spectroscopy of Cu2+in hen egg-white Competencefactor lysozyme, 5243 Switches in macromolecular synthesis during induction of competence Propertiesof a copper-containingcytochrome claa3 complex:A terminal for transformation of Streptococcus sanguis, 6062 oxidase.ofthe extremethermophile Thermus thermophilus HB8, 147 Competition,biological Two-subunitcytochrome c oxidase (cytochromeaa3) from Paracoccus Biological competition: Decision rules, pattern formation, and dentrificans,196 oscillations, 2338 Cornea Competitive intransitivity and size-frequency distributions of interacting Regulation of stromal cell collagenase production in adult rabbit cornea: populations, 5355 In vitro stimulation and inhibition by epithelial cell products, 5331 Resource variation and structure of British bird communities, 4185 Coronaryartery Complement Autoradiographicmethod for measuringischemic myocardium at risk: Assembly of subcomponents Clr and Cls of first component of Effects of on infarct size after experimental coronary artery complement: Electron microscopic and ultracentrifugal studies, 7014 occlusion,6119 Complement proteins: Covalent binding and hemolytic activity, 7194 Coronary atherosclerosis associated with hyperapobetalipoproteinemia Inherited structural polymorphism of the fourth component of human [increased protein but normal cholesterol levels in human plasma low complement, 3576 density (/) lipoproteins], 604 Internal thiolester bond: Evidence for presence in third component of Dissociation of vasoconstrictor and platelet aggregatory activities of human complement, 5764 thromboxane by carbocyclic thromboxane A2, a stable analog of Lateral distribution and diffusion of C3b receptor of complement, HLA thromboxane A2, 1706 antigens, and lipid probes in peripheral blood leukocytes, 6587 Prolongedderangements of canine myocardialpurine metabolismafter a Partial amino acid sequencesof murinefourth componentof brief coronaryartery occlusion not associatedwith anatomicevidence complement(C4): Demonstration of homologywith human C4 and of necrosis, 5471 identificationof the amino-terminalsubunit in pro-C4,4275 Corpusallatum . Complement,alternative pathway Neuroendocrineregulation of corpusallatum activity in Manducasexta: Antibody-independentactivation of alternativecomplement pathway by Sequential neurohormonal and nervous inhibition in the last-instar measles virus-infected cells, 559 larva,4407 Human factor D: Active site amino acid sequence, 4938 Corrections Partial amino acid sequenceof human factor D: Homologywith serine Attractants and repellents control demethylation of methylated proteases, 1116 chemotaxisproteins in Escherichiacoli, 2353 Partialsequence of humancomplement component factor B: Novel type Chemicalcarcinogen-modified DNA recognizedby a DNA-binding of serine protease, 4923 protein, 7510 Completeneglect of differentialoverlap Cloningand mappingof BamHI endonucleasefragments of DNA from Circular dichroism of adenosine derivatives constrained in the syn form: 'the transforming B95-8 strain of Epstein-Barr virus, 7510 Calculations, 3398 Cloningof active thymidinekinase gene of herpes simplex virus type 1 in Computerprogram Escherichiacoli K-12, 4390 Fast algorithm for predicting secondary structure of single-stranded Cytokinininhibition of respirationin mitochondriafrom six plant RNA, 6309 species, 6941 Computerreconstruction Delipidationof bacteriorhodopsinand reconstitutionwith exogenous Growing optic nerve fibers follow neighbors during embryogenesis, 4374 phopholipid,2353 ConcanavalinA DNA crosslinkingand cytotoxicityin normaland transformedhuman see also Receptor,concanavalin A cells treated with antitumornitrosoureas, 1721 Activation of early enzyme production in small lymphocytes in response Electrical excitability: Spectrum of properties in progeny of a single to high, nonmitogenic concentrations of concanavalin A, 3479 embryonic neuroblast, 4390 Membrane potential changes during mitogenic stimulation of mouse Elongation of primed DNA templates by eukaryotic DNA , spleen lymphocytes, 2200 7510 Microtubule assembly and concanavalin A capping in lymphocytes: Evolution of eusociality in termites, 3070 Reappraisal using normal and abnormal human peripheral blood cells, Fluorescencestaining of actin cytoskeletonin living cells with 3499 7-nitrobenz-2-oxa-l,3-diazole-phallacidin, 3747 Phospholipidmethylation: A biochemicalsignal modulatinglymphocyte Globin domains: Heme binding to the central exon product, 3747 mitogenesis, 862 Inheritance of acquired immunological tolerance to foreign Synthetic glycolipids: Functional incorporation into cells, 2510 histocompatibility antigens in mice, 4390 Conditioning Inheritanceof chloroplastDNA in Chlamydomonasreinhardtii, 7510 Resurgence of.responding after cessation of response-independent IntegratedMoloney sarcoma proviral DNA sequences:Cloning in reinforcement, 6251 bacteriophage X, 1229 Conductivity Interchain disulfide bond: Effect on hapten binding properties of light Protein-methylglyoxal adduct: Spectroscopic studies, 949 chain dimer of protein 315, 1229 Conformationaltransition Interferon inhibits conversion of 3T3-L1 mouse fibroblasts into Electron tunneling process and segment mobility of macromolecules, adipocytes, 6941 7218 Intermediate filaments from baby hamster kidney (BHK-21) cells: In Conjugation,bacterial vitro assembly, 1721 Chromosomal mutations of Escherichia .coli that alter expression of Large and persistent electrical currents enter transected lamprey spinal conjugativeplasmid functions, 513 cord, 4390 Downloaded by guest on September 29, 2021 7558 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Major intracellular cations and growth control: Correspondence among cis-4-Cyclohexene-1,2-dicarboximide magnesium content, protein synthesis, and onset of DNA synthesis in cis-4-Cyclohexene-1,2-dicarboximide: Inhibitor of BALB-c 3T3 cells, 1721 phytochrome-promoted seed germination, 3408 Method for preparing cultures of central neurons: Cytochemical and Cycloheximide immunochemical studies, 2353 Cycloheximide-induced reversal of adrenocorticotropin effects on Mouse mammary tumor virus: In vitro infectivity assay, 689 steroidogenesis and adrenal phospholipids in vivo: Kinetic aspects, Organelle DNA variation and systematic relationships in genus Zea: 7189 Teosinte, 1229 Prevalent deficiency in tumor cells of cycloheximide-induced cycle Presumptive common precursor for neuronal and glial cell lineages in arrest, 4123 mouse hypothalamus, 6941 Vimentin filament organization in monkey kidney CV-1 cells: Specific Serum factors modify cellular requirement for Ca2+, K+, Mg2+, disruption by diphtheria toxin, exotoxin A, and cycloheximide, 7267 phosphate ions, and 2-oxocarboxylic acids for multiplication of normal Cysteine human fibroblasts, 6254 Cysteine and y-glutamylcysteine moieties: Excretion in human and Structure of parathyroid hormone: Theoretical study, 6941 experimental animal y-glutamyl transpeptidase deficiency, 3384 Transepithelial migration of human neutrophils: An in vitro model Cysteine and methionine: Selective oxidation in normal and senile system, 6941 cataractous lenses, 1274 Transposition of Escherichia coli insertion element -y generates a Slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) five-base-pair repeat, 689 cells: Effect of cysteine on SRS profile, 6481 Triplet states in photosystem I of spinach chloroplasts and Cytidylyl-3',5'-adenosine subchloroplast particles, 1229 X-ray structure of a cytidylyl-3',5'-adenosine-proflavine complex: A Vero cells injected with adenovirus type 2 mRNA produce authentic self-paired parallel-chain double helical dimer with an intercalated viral polypeptide patterns: Early mRNA promotes growth of acridine dye, 1852 adenovirus-associated virus, 3070 Cytochalasin Cortexolone Manufacture of diploid/tetraploid chimeric mice, 6012 (2'-5')01igo(A) polymerase activity: Elevated levels in human Prostaglandin synthesis by macrophages requires a specific lymphoblastoid cells treated with glucocorticoids, 6506 receptor-ligand interaction, 4279 Corticalbarrel Regulation of stromal cell collagenase production in adult rabbit cornea: Cytochrome oxidase of cortical barrels: Histochemical changes after In vitro stimulation and inhibition by epithelial cell products, 5331 vibrissal removal in neonatal and adult mice, 2333 Spreading of fibroblasts in medium containing cytochalasin B: Corticotropin Formation of lamellar cytoplasm as a combination of several see also Receptor,corticotropin functionally different processes, 5919 Adrenocortical response to corticotropin is potentiated by part of Cytochrome b amino-terminal region of pro-corticotropin/endorphin, 2239 Flash-activated cyclic electron transport system constructed by using Adrenocorticotropic hormone increases specific proteins of the bacterial reaction centers and ubiquinone-cytochrome b-cl/c segment mitochondrial fraction that are translated inside or outside this of mitochondria, 6339 organelle in cultured adrenal tumor cells, 4648 Interaction between cytochrome b5 and : Involvement of P66 Biosynthesis of precursor corticotropin/endorphin-, corticotropin-, (E10) and /95 (FG2) lysyl residues of hemoglobin, 1917 a-melanotropin-, /-lipotropin-, and ,f-endorphin-like material by Cytochrome c cultured neonatal rat hypothalamic neurons, 1880 see also Gene, cytochrome c Humangenomic DNA encodingthe pro-opiomelanocortinpeptide: Anion binding sites on cytochrome c: Mapping by differential chemical Structural organization, 4890 modification of lysine residues, 4439 Human leukocyte interferon: Structural and biological relatedness to Crystallization of middle part of mitochondrial electron transfer chain: adrenocorticotropic hormone and endorphins, 5972 Cytochrome.bcl-cytochrome c complex, 5084 Precursor to corticotropin and f-lipotropin in humans: Processing, 5211 Flash-activated cyclic electron transport system constructed by using Regulation of ornithine decarboxylase activity by corticotropin in bacterial reaction centers and ubiquinone-cytochrome b-cl/c segment adrenocortical tumor cell clones: Roles of cyclic AMP and cyclic of mitochondria, 6339 AMP-dependentprotein kinase,2767 Redox conformation changes in refined tuna cytochrome c, 6371 Cortisol Cytochrome oxidase Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: Properties of a copper-containing cytochrome claa3 complex: A terminal Action on proteinphosphatase(s) and its inhibitor(s),5711 oxidase of the extreme thermophile Thermus thermophilus HB8, 147 Cortisol21-mesylate Cytochrome c oxidase (EC 1.9.3.1) Unique long-actingantiglucocorticoid in whole and brokencell systems, Copper electron-nuclear double resonance of cytochrome c oxidase, 1452 5167 Crystallization of part of the miotchondrial electron transfer chain: Corynebacteriumfascians Cytochrome c oxidase-cytochrome c complex, 928 Cytokinin production, presence of plasmids, and fasciation caused by Cytochrome oxidase: An alternative model, 1806 strains of Corynebacterium fascians, 619 Cytochrome oxidase of cortical barrels: Histochemical changes after CoxsackieB virus vibrissal removal in neonatal and adult mice, 2333 Sequence of picornavirus RNAs containing a radioiodinated 5'-linked Cytoplasmically made subunits of yeast mitochondrial F1-ATPase and peptide revealsa conserved5' sequence,303 cytochrome c oxidase are synthesized as individual precursors, not as Crab polyproteins, 3998 see Carcinusmaenas; Geryon quinquedens Four cytoplasmically made subunits of yeast mitochondrial cytochrome c Creatinekinase oxidase are synthesized individually and not as a polyprotein, 4160 Anchorage-independent muscle cell differentiation, 5297 Ion-transport chain of cytochrome oxidase: The two chain-direct Creatinephosphate coupling principle of energy coupling, 6391 Measurement of changes in high-energy in the cardiac cycle Mitochondrial membrane biogenesis: Identification of precursor to yeast by using gated 31p nuclear magnetic resonance, 3654 cytochrome c oxidase subunit II, an integral polypeptide, 142 Crithidiafasciculata Reagents that convert cytochrome oxidase from an inactive to an active Dihydrofolate reductase:thymidylate synthase, a bifunctional coupling state, 1951 polypeptide from Crithidia fasciculata, 5802 Two-subunit cytochrome c oxidase (cytochrome aa3) from Paracoccus Crohndisease dentrificans, 196 Crohn disease lymph node homogenates produce murine lymphoma in Cytochrome P-450 athymic mice, 588 Cytochrome P-450: Synthesis and insertion into endoplasmic reticulum Crowngall tumor membranes, 965 Agropine in "null-type" crown gall tumors: Generality of the opine Enhanced drug-metabolizing capacity within liver adjacent to human concept, 2693 and rat liver tumors, 600 Plasmid-dependent temperature-sensitive phase in crown gall High-performance liquid chromatography technique for resolving tumorigenesis, 2688 multiple forms of hepatic membrane-bound cytochrome P-450, 6473 Proteins encoded by Agrobacterium tumefaciens Ti plasmid DNA Cytochrome bcl particle (T-DNA) in crown gall tumors, 2666 see Ubiquinol-cytochrome c reductase Recombination between higher plant DNA and Ti plasmid of Cytochrome P-680 Agrobacteriumtumefaciens, 6448 Magnetic field-induced increase in chlorophyll a delayed fluorescence of T-DNA from Agrobacterium Ti plasmid is in the nuclear DNA fraction photosystem II: A 100- to 200-ns component between 4.2 and 300 K, of crown gall tumor cells, 4060 5889 b-Crystallin Cytochrome P-700 Comparison of two b-crystallin genes in chicken, 5879 Stoichiometry of system I and system II reaction centers and of Cucurbitacin plastoquinone in different photosynthetic membranes, 4712 Cucurbitacins as kairomones for diabroticite beetles, 3769 Triplet states in photosystem I of spinach chloroplasts and Cunninghamellaelegans subchloroplast particles (correction), 1229 Fungal oxidation of (?)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: Cytokinin Formation of diastereomeric benzo[a]pyrene 9,10-diol 7,8-epoxides, Auxin-induced changes in patterns of protein synthesis in soybean 4554 hypocotyl, 357 Cyanobacterium Cytokinin inhibition of respiration in mitochondria from six plant Transformation in Agmenellum quadruplicatum, 6052 species, 4731 CyclicAMP Cytokinin inhibition of respiration in mitochondria from six plant see 3',5'-Cyclic-nucleotide phosphodiesterase species (correction), 6941 3',5'-Cyclic-nucleotide-phosphodiesterase(EC 3.1.4.17) Cytokinin production, presence of plasmids, and fasciation caused by Calmodulin activation of plant microsomal Ca2+ uptake, 7311 strains of Corynebacterium fascians, 619 Cyclic AMP metabolism modulated by S-adenosylhomocysteine and Cytoplasm S-3-deazaadenosylhomocysteine in mouse lymphocytes, 5639 Autonomous movements of cytoplasmic fragments, 6639 Downloaded by guest on September 29, 2021 Proc. 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Cytosine,5-methyl- 2-Deoxyglucose Methylation of foreign DNA sequences in eukaryotic cells, 6463 Development of circadian rhythmicity and light responsiveness in the rat 5-Methylcytosine: Identification in DNA fragments immobilized on suprachiasmatic nucleus: A study using the 2-deoxy[1-14C]glucose nitrocellulosepaper, 3581 method, 1204 Cytoskeleton Deoxyribonuclease Adhesionplaques of Rous sarcomavirus-transformed cells contain the -sensitive structure reconstituted on active genes, src gene product, 3514 1787 /-Adrenergic receptor in frog erythrocyte membranes: Cytoskeletal Frequency and levels of antibodies to Epstein-Barr virus-specific DNase constraint,6401 are elevated in patients with nasopharyngealcarcinoma, 6162 Anchorageof a band 3 populationat erythrocytecytoplasmic membrane Limited DNase I nicking as a probe of gene conformation, 1907 surface: Protein rotational diffusion measurements, 4702 Deoxyribonucleicacid Appearance of cytoskeletal components on the surface of leukemia cells see also Hybridization, nucleic acid; Protein, deoxyribonucleic and of lymphocytes transformed by mitogens and Epstein-Barr virus, acid-binding 4979 Deoxyribonucleicacid alkylation Associationof the src gene productof Rous sarcomavirus with DNA alkylation and unwinding induced by benzo[a]pyrene diol epoxide: cytoskeletal structures of chicken embryo fibroblasts, 3484 Modulation by ionic strength and superhelicity, 2000 Calcium control of intestinal microvillus cytoskeleton: Implications for Deoxyribonucleicacid, bacterial regulation of microfilament organizations, 6458 see also Escherichiacoli chromosome CytoskeletalF-actin patternsquantitated with fluorescein Biparentalproducts of bacterialprotoplast fusion showingunequal isothiocyanate-phalloidinin normaland transformedcells, 6624 parentalchromosome expression, 3553 Cytoskeletalproteins vinculin and a-actinin:Altered distributions in ClonedDNA containinggenes responsiblefor branched-chainamino acid culturedfibroblasts transformed by Rous sarcomavirus, 6687 transportin Escherichiacoli: Structuraland functionalanalysis, 1412 Cytoskeletonof digitonin-treatedrat hepatocytes,3430 Duplex DNA containingsingle-stranded regions: Recognition by recA Desensitization of enucleated cells to hormones and role of cytoskeleton protein, 2569 in control of normal hormonal response, 4798 Inversions of specific DNA segments in flagellar phase variation of Fast axonal transport in presence of high Ca2+: Evidence that Salmonella and inversion systems of bacteriophages P1 and Mu, 7338 microtubules are not required, 5909 Nucleotide sequence of an invertible controlling element, 4196 Fluorescence staining of actin cytoskeleton in living cells with Deoxyribonucleicacid, bacteriophage 7-nitrobenz-2-oxa-1,3-diazole-phallacidin, 980 BacteriophageT7 DNA replication:Physical mappingof primaryand Fluorescence staining of actin cytoskeleton in living cells with secondaryorigins, 2656 7-nitrobenz-2-oxa-l,3-diazole-phallacidin (correction), 3747 DNA sequenceof regulatoryregion for integrationgene of bacteriophage Functional domains of human erythrocyte spectrin, 6592 X, 2477 High molecular weight polypeptides (270,000-340,000) from cultured Escherichiacoli replicationprotein that recognizesa unique sequence cells are related to hog brain microtubule-associated proteins but within a hairpin region in kX174 DNA, 799 copurify with intermediate filaments, 4808 Nucleotidesequence of primaryorigin of bacteriphageT7 DNA Intermediate filaments of baby hamster kidney (BHK-21) cells and replications: Relationship to adjacent genes and regulatory elements, bovine epidermal keratinocytes have similar ultrastructures and 3917 subunit domain structures, 4534 Protein p3 is linked to DNA of phage k29through a phosphoesterbond Lateral mobility of band 3 in human erythrocyte membrane studied by between serine and 5'-dAMP, 6425 fluorescence photobleaching recovery: Control by cytoskeletal RNA in D loops of intracellular X DNA, 2153 interactions, 2537 Separationof randomfragments of DNA accordingto propertiesof their Liver tumors distinguished by immunofluorescence microscopy with sequences,4420 antibodies to proteins of intermediate-sized filaments, 4948 Site-specific recombination functions of bacteriophage X: DNA sequence Major lens membrane protein: Synthesis in vitro, 725 of regulatoryregions and overlappingstructural genes for Int and Xis, Membrane protein lateral mobility: Modulation by polyphosphates and 2482 polyamines, 1457 5'-Terminaloligonucleotide fragments of RNA transcriptssynthesized by Microtubulesand intermediatefilaments in chickengizzard cells: bacteriophageT3-induced RNA polymerasefrom T3 DNA: Isolation Associationas detected by double immunofluorescence,4769 and sequence determination, 3908 Microtubulesof cells: Visualizationin situ by indirect Deoxyribonucleicacid binding immunofluorescence,6657 Differentialaffinities of simian virus 40 largetumor antigen for DNA, Model for cappingderived from inhibitionof surfacereceptor capping by 220 free fatty acids, 437 Escherichiacoli L-arabinoseoperon: Binding sites of regulatoryproteins Nucleation and kinetics of microtubule assembly, 7302 and a mechanism of positive and negative regulation, 3346 Reversible translocation of cytoplasmic actin into the nucleus caused by Oligodeoxynucleotide binding of mouse uterine cytosol estradiol dimethyl sulfoxide, 5268 receptors:Specificity, 3341 Taxol stabilizes microtubules in mouse fibroblast cells, 1561 Photochemicallyinduced dynamic nuclear polarization investigation of Cytotoxicity complexformation of the NH2-terminalDNA-binding domain of lac see also Cell, T, cytotoxic repressorwith poly[d(AT)],5145 Monocyte-mediated cytotoxicity: Oxidative mechanisms, 584 Deoxyribonucleicacid, chloroplast Natural cytotoxic cells against solid tumors in mice: Blocking of Clonedmaize chloroplastDNA sequences:Preferential transcription by cytotoxicity by D-mannose, 2895 maize chloroplastRNA polymerase,822 Subpopulations of human peripheral granulocytes and monocytes Inheritanceof chloroplastDNA in Chlamydomonasreinhardtii, 6067 express receptors for IgA, 3640 Inheritanceof chloroplastDNA in Chlamydomonasreinhardtii Syngeneic tumor cells can induce alloreactive T killer cells: Biological (correction), 7510 role for transplantation antigens, 5409 5-Methylcytosine:Identification in DNA fragmentsimmobilized on nitrocellulosepaper, 3581 Daphnia galeata mendotae Organelle DNA variation and systematic relationships in genus Zea: Population oscillations and energy reserves in planktonic cladocera and Teosinte (correction), 1229 their consequences to competition, 1716 Sizes, locations, and directions of transcription of two genes on a cloned Daunomycin maize chloroplast DNA sequence, 1832 Molecularstructure of anticancerdrug-DNA complex:Daunomycin plus Deoxyribonucleicacid, closed circular d(CpGpTpApCpG),7204 Targeteddeletions of sequencesfrom closed circularDNA, 2455 Defective interferingparticle Deoxyribonucleicacid, complementary Influenzadefective interfering viral RNA is formedby internaldeletion Cloning of DNA complementary to measles virus mRNA encoding of genomicRNA, 215 nucleocapsid protein, 3686 Synthesis in vitro of full-length complement of defective-interfering Molecularcloning of developmentallyregulated, low-abundance mRNA particle RNA of vesicular stomatitis virus, 3927 sequencesfrom embryonicmuscle, 4519 Deoxyadenosine Molecularcloning of human interferoncDNA, 4003 Deoxycytidinekinase-mediated toxicity of deoxyadenosineanalogs Two species of full-length cDNA are synthesized in high yield by towardmalignant human lymphoblastsin vitro and towardmurine melittin-treatedavian retrovirusparticles, 847 L1210leukemia in vivo, 6865 Deoxyribonucleicacid, crab Deoxyadenosine5'-monophosphate Selective amplification of variants of a complex repeating unit in DNA of Protein p3 is linked to DNA of phage <29 through a phosphoester bond a crustacean,2786 betweenserine and 5'-dAMP,6425 Deoxyribonucleicacid damage Deoxyadenosine5'-triphosphate lexA gene productrepresses its own promoter,1932 Adenosinekinase-deficient human lymphoblastoid cell line: Resistance Radiosensitivity in ataxia-telangiectasia: A new explanation, 7315 to effects of deoxyadenosineon growth,S-adenosylhomocysteine Deoxyribonucleicacid double helix hydrolaseinactivation, and dATP accumulation,4292 Open state in long polynucleotidedouble helices:Possibility of soliton 2'-Deoxycoformycin excitations,7222 Immune dysfunction associated with adenosine deaminase deficiency: Tetramerd(CpGpCpG) crystallizes as a left-handeddouble helix, 4016 Animal model, 4899 Deoxyribonucleicacid, double-stranded Deoxycorticosterone DNA synaptase: An enzyme that fuses DNA molecules at a region of Deoxycorticosteronebiosynthesis in human kidney:Potential for homology, 2390 formation of a potent mineralocorticosteroid in its site of action, 7069 Initiationof genetic recombination:Homologous pairing between duplex Deoxycytidine kinase DNA moleculespromoted by recA protein, 3962 Deoxycytidinekinase-mediated toxicity of deoxyadenosineanalogs Transcription of tRNA genes in vivo: Single-stranded compared to towardmalignant human lymphoblasts in vitro and towardmurine double-stranded templates, 4147 L1210leukemia in vivo, 6865 Downloaded by guest on September 29, 2021 7560 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Deoxyribonucleicacid-drug interaction Deoxyribonucleicacid, plasmid 9-Aminoacridine:Site exclusionand sequencespecificity in bindingto Geneticrecombination of bacterialplasmid DNA: Electronmicroscopic deoxytetranucleotidedpApGpCpT, 6453 analysisof in vitro intramolecularrecombination, 4847 Chemicalcarcinogen-modified DNA recognizedby a DNA-binding Proteins encodedby Agrobacteriumtumefaciens Ti plasmidDNA protein,3201 (T-DNA) in crowngall tumors,2666 Chemicalcarcinogen-modified DNA recognizedby a DNA-binding Segment-directedmutagenesis: Construction in vitro of point mutations protein (correction),7510 limited to a small predeterminedregion of a circularDNA molecule, Chromophoreand apo-protein:Roles in neocarzinostatinaction, 1970 5375 Conformationof poly(dG-dC)-poly(dG-dC)modified by carcinogens T-DNA from AgrobacteriumTi plasmidis in the nuclearDNA fraction N-acetoxy-N-acetyl-2-aminofluoreneand of crowngall tumorcells, 4060 N-hydroxy-N-2-aminofluorene,4597 Two Escherichiacoli factor Y effectorsites identifiednear originsof Correlationbetween DNA affinity and mutagenicityof several replicationof plasmidsColEl and pBR322,6521 3-amino-1-methyl-5H-pyrido[4,3-b]indoles,1427 Deoxyribonucleicacid polymerase Indicatorsequence of humanDNA used to study DNA damageby see Deoxyribonucleicacid methylbis(2-chloroethyl)amine,6546 Deoxyribonucleicacid, recombinant Molecularstructure of anticancerdrug-DNA complex: Daunomycin plus Actin gene sequencesin sea urchin:Molecular cloning of an d(CpGpTpApCpG),7204 intron-containingDNA sequencecoding for a cytoplasmicactin, 5683 X-ray structureof a cytidylyl-3',5'-adenosine-proflavinecomplex: A Biologicalactivity of cloned Moloneysarcoma virus DNA: Terminally self-pairedparallel-chain double helical dimer with an intercalated redundantsequences may enhancetransformation efficiency, 3504 acridinedye, 1852 Broadhost rangeDNA cloningsystem for Gram-negativebacteria: Deoxyribonucleicacid gyrase Constructionof a gene bank of Rhizobiummeliloti, 7347 DNA gyraseaction involvesintroduction of transientdouble-strand Centromere-linkedCDC10 gene: Isolation by complementationin yeast, breaksinto DNA, 1847 2173 DNA gyraseon the bacterialchromosome: Possibility of two levels of Cloningand analysisof a cDNA codingfor bovine prothrombin,5153 action, 6879 Cloningand direct examinationof a structurallyabnormal human Supercoilsin prokaryoticDNA restrainedin vivo, 1331 f-thalassemia globin gene, 3558 Deoxyribonucleicacid, human Cloningand mappingof BamHI endonucleasefragments of DNA from Reiterationfrequency mapping: Analysis of repetitivesequence transformingB95-8 strain of Epstein-Barrvirus, 3860 organizationwithin cloned DNA fragmentscontaining human initiator Cloningand mappingof BamHI endonucleasefragments of DNA from methioninetRNA gene, 5668 the transformingB95-8 strain of Epstein-Barrvirus (correction),7510 Deoxyribonucleicacid, kinetoplast Closelylinked adult chickena-globin genes in recombinantDNAs, 2596 Sequencesof two kinetoplastDNA minicirclesof Trypanosomabrucei, CompositetRNA gene constructedby anticodonloop transplant,5092 2445 Cotransferof circularand linear prokaryoticand eukaryoticDNA Trypanosomacruzi: Strains and clones can be characterizedby pattern sequencesinto mouse cells, 4852 of restrictionendonuclease products of kinetoplastDNA minicircles, Cytoplasmicprocessing of myosin heavy chain messengerRNA: Evidence 6810 providedby using a recombinantDNA plasmid,5749 Deoxyribonucleicacid, macronuclear DNA-dependenttranscription of adenovirusgenes in a soluble whole-cell Aggregationin vitro of gene-sizedDNA moleculesof the ciliate extract,3855 Stylonychiamytilus, 4104 DNA segmentsfrom specific humanchromosomes: Isolation and Putative actin genes in macronucleusof Oxytrichafallax, 5336 localization,2829 Deoxyribonucleicacid, mammalian DNA sequencescomplementary to mRNAs for a and /f subunits of Cytotypicallyspecific transfectingactivity of DNA from C57BL/Ka thyrotropin:Synthesis, cloning, and identification,3149 mouse cells producingthymotropic in contrastto nonthymotropic DNA sequencessurrounding human y-, 6-, and /-globin genes:Cloning retroviruses,6189 and characterization,4229 DNA sequenceof baboonhighly repeatedDNA: Evolutionby DNA-transformedmurine teratocarcinoma cells: Regulationof nonrandomunequal crossovers, 2129 expressionof simian virus 40 tumor antigen in stem versus Ubiquitous,interspersed repeated sequences in mammaliangenomes, differentiatedcells, 4875 1398 Ecotropicproviral sequences: Identification in inbredmouse strainswith Deoxyribonucleicacid, methylated a cloned subgenomicDNA fragment,5779 Methylationof foreignDNA sequencesin eukaryoticcells, 6463 Epstein-Barrvirus (B95-8) DNA VII: Molecularcloning and detailed 5-Methylcytosine:Identification in DNA fragmentsimmobilized on mapping,2999 nitrocellulosepaper, 3581 Eukaryoticsignal sequencetransports insulin antigenin Escherichia Tissue-specificDNA methylationin a cluster of rabbit/-like globin coli, 3369 genes, 6634 Genetictransformation of mouse embryosby microinjectionof purified Deoxyribonucleicacid, mismatchcorrection DNA, 7380 Escherichiacoli mutatormutants deficient in methylation-instructed a-Globin-likegene that has cleanly lost both globin intervening DNA mismatch-correction,1063 sequences,2806 Deoxyribonucleicacid, mitochondrial Hepatitis B surfaceantigen particles excreted from mouse cells Deletion mutantsof Neurosporacrassa mitochondrialDNA and their transformedwith cloned viral DNA, 4549 relationshipto "stop-start"growth phenotype, 6032 Highly polymorphiclocus in humanDNA, 6754 DNA-proteininteractions in Drosophilamelanogaster mitochondrial ImmunoglobulinC, gene:Expression in mouse T and B lymphoidand genomeas deducedfrom trimethylpsoralencrosslinking patterns, 4118 myeloidcell lines, 2876 Extrachromosomalgenetic elements:Preferential inclusion in yeast ImmunoglobulinV/J recombinationis accompaniedby deletion of meiotic spores,5380 joiningsite and variableregion segments, 6022 Maternalinheritance of humanmitochondrial DNA, 6715 Indiscriminaterecombination in simian virus 40-infectedmonkey cells, MitochondrialDNA polymorphism:Variants detected by restriction 4861 enzymesdiffer in nucleotidesequence rather than in methylation,6415 IntegratedMoloney sarcoma proviral DNA sequences:Cloning in OrganelleDNA variationand systematicrelationships in genus Zea: bacteriophageX (correction),1229 Teosinte (correction),1229 Integrationin vivo into simian virus 40 DNA of a sequencethat Polymorphismin mitochondrialDNA of humansas revealedby resemblesa certainfamily of genomicinterspersed repeated sequences, restrictionendonuclease analysis, 3605 4514 Replicatorregions of yeast mitochondrialDNA responsiblefor IntracisternalA-particle genes: Identification in genomeof Mus suppressiveness,3942 musculusand comparisonof multipleisolates from a mousegene Uniparentalpropagation of mitochondrialDNA in'mouse-human cell library,3571 hybrids,4079 Isolationof two closely relatedvitellogenin genes, includingtheir Deoxyribonucleicacid nucleotidyltransferase flankingregions, from a Xenopus laevis gene library,1437 A /-like DNA polymeraseactivity in slime mold Dictyostelium Mappingof transformingregion of Harveymurine sarcoma virus genome discoideum,3317 by using insertion-deletionmutants constructedin vitro, 4674 Apurinic/apyrimidinicendonucleases in repairof pyrimidinedimers and Molecularcloning of unintegratedMoloney mouse sarcomavirus DNA in other lesions in DNA, 4602 bacteriophageX, 1773 Elongationof primedDNA templates by eukaryoticDNA polymerases, Moloneymouse sarcomavirus-specific sequences from uninfectedmouse 5827 cells: Identificationand molecularcloning, 2651 Elongationof primedDNA templates by eukaryoticDNA polymerases Mouse immunoglobulinD: Constructionand characterizationof a cloned (correction),7510 I chain cDNA, 7405 Deoxyribonucleicacid nucleotidyltransferase(EC 2.7.7.7) Mouse metallothionein-Igene: Isolation and characterization,6511 Acyclovirinhibition of Epstein-Barrvirus replication,5163 Nitrogenasegenes: Interspecies homology, 191 DNA polymerasea mutants from a Drosophilamelanogaster cell line, No apparentnucleotide sequence specificity in cellularDNA juxtaposed 7049 to retrovirus proviruses, 7357 Multienzyme complex for metabolic channeling in mammalian DNA Novel bacteriophage X cloning vector, 5172 replication, 3312 Nucleotide sequence of a cloned structural gene coding for a precursor of Deoxyribonucleicacid nucleotidyltransferase,ribonucleic acid-dependent pancreaticsomatostatin, 5869 (EC 2.7.7.7) is synthesized in mouse cells transformed with natural Reversetranscriptase: Reactivity toward (s4U,U), copolymersand chickenovalbumin gene, 244 spin-labeled nucleic acid lattices, 4574 Overlappinggenomic clones coveringchicken 0a2 (type I) collagengene: RNA primer used in synthesis of anticomplementary DNA by reverse Isolation and characterization, 7059 transcriptase of avian myeloblastosis virus, 1316 Polyoma large tumor antigen is not required for tumorigenesis mediated Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as by viral DNA, 1336 determined by a modification of the dideoxynucleotide method, 3196 Potato spindle tuber viroid cDNA sequences: Molecular cloning and characterization, 5302 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7561

Proviral genome associated with avian myeloblastic leukemia, 3004 Replication origin complex isolated from Escherichia coli, 262 Recombinant DNAs derived from genomes of human hepatitis B.virti Simian virus 40 originsdefective in tumor antigen bindingand DNA and woodchuck hepatitis virus: Isolation, characterization, and replication: Construction and analysis, 6491 comparison, 1842 Synaptonemal complexes are premeiotic interphase in mouse Recombinantplasmids constructed containing rat muscle actin and spermatocyte, 6720 myosin light chain DNA sequences, 960 Deoxyribonucleicacid, satellite Recombinants between avian sarcoma virus genome and chicken helper DNA sequenceof baboonhighly repeatedDNA: Evolutionby factor gene of host cell: Cloning by transfection, 3014 nonrandomunequal crossovers, 2129 Recombination between higher plant DNA and Ti plasmid of 5-Methylcytosine: Identification in DNA fragments immobilized on Agrobacterium tumefaciens, 6448 nitrocellulose paper, 3581 Reiteration frequency mapping: Analysis of repetitive sequence Deoxyribonucleicacid, sea urchin organizationwithin cloned DNA fragmentscontaining human initiator Four sizes of transcript produced by a single sea urchin gene expressed methionine tRNA gene, 5668 in early embryos, 3259 Replication of plasmids from Staphylococcus aureus in Escherichia coli, Deoxyribonucleicacid structure 7333 Conformationalflexibility of DNA: Polymorphismand handedness,6486 Sequences of two kinetoplast DNA minicircles of Trypanosoma brucei, Deoxyribonucleicacid, superhelical 2445 DNA gyraseaction involves introductionof transientdouble-strand Structureof endogenousmurine leukemia virus DNA in mouse genomes, breaksinto DNA, 1847 5774 Invertedrepeat as a recognizablestructural feature in supercoiledDNA Transformation of Streptococcus pneumoniae with S. pneumoniae-X molecules, 6468 phage hybridDNA: Inductionof deletions, 3534 Supercoilsin prokaryoticDNA restrainedin vivo, 1331 Deoxyribonucleicacid repair Deoxyribonucleicacid synaptase Apurinic/apyrimidinicendonucleases in repairof pyrimidinedimers and DNA synaptase: An enzyme that fuses DNA molecules at a region of other lesions in DNA, 4602 homology, 2390 DNA crosslinkingand cytotoxicityin normaland transformedhuman Deoxyribonucleicacid synthesis cells treated with antitumor nitrosoureas, 467 Activation of early enzyme production in small lymphocytes in response DNA crosslinkingand cytotoxicityin normaland transformedhuman to high, nonmitogenic concentrations of concanavalin A, 3479 cells treated with antitumor nitrosoureas (correction), 1721 Antibody directed against Friend leukemia virus stimulates DNA Effect of uncouplers on radiosensitivity and mutagenicity in x-irradiated synthesis in subpopulation of mouse B lymphocytes, 1486 mammalian cells, 2702 DNA gyraseon the bacterialchromosome: Possibility of two levels of Error-freeexcision of cytotoxic,mutagenic N2-deoxyguanosine DNA action, 6879 adduct formedin humanfibroblasts by Growthin kidney epithelial cells induced in culture by Na+, 6654 (?)-7f/,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, Inhibitionof biologicalactivity of multiplication-stimulatingactivity by 5933 bindingto its carrierprotein, 7252 Methotrexate-inducedmisincorporation of uracilinto DNA, 1956 Majorintracellular cations and growthcontrol: Correspondence among Postreplicationrepair and susceptibilityof Chinesehamster cells to magnesiumcontent, protein synthesis, and onset of DNA synthesis in cytotoxicand mutageniceffects of alkylatingagents, 6072 BALB-c 3T3 cells (correction),1721 Deoxyribonucleicacid replication RNA primerused in synthesis of anticomplementaryDNA by reverse Adenovirus DNA replication in vitro: Characterization of a protein transcriptase of avian myeloblastosis virus, 1316 covalently linked to nascent DNA strands, 5105 Two Escherichia coli factor Y effector sites identified near origins of Association of 2-,m DNA plasmid with yeast folded chromosomes, 3144 replicationof plasmidsColEl and pBR322,6521 Bacteriophage T7 DNA replication: Physical mapping of primary and Deoxyribonucleicacid, thermaldenaturation secondary origins, 2656 Stability of DNA in nucleosomes,4044 Cloning of an origin of DNA replication of Xenopus laevis, 5292 Deoxyribonucleicacid, viral Copy-number mutants of plasmid carrying replication origin of Adenovirus DNA replication in vitro: Characterization of a protein Escherichiacoli chromosome:Evidence for a controlregion of covalentlylinked to nascent DNA strands,5105 replication,3993 Amplificationof integratedviral DNA sequencesin polyoma Differentialamplification of specific areas of phage T4 genomeas virus-transformedcells, 3850 revealedby hybridizationto cloned genetic segments,5064 Biological activity of cloned Moloney sarcoma virus DNA: Terminally DNA-membraneassociation is necessaryfor initiation of chromosomal redundantsequences may enhancetransformation efficiency, 3504 and plasmid replication in Bacillus subtilis, 2834 Cellularsequences are present in presumptiveavian myeloblastosisvirus DNA replication in vitro of recombinant plasmid DNAs containing the genome, 5177 originof progenyreplicative form DNA synthesis of phage bX174, Chronic hepatitis in chimpanzee carriers of hepatitis B virus: 5182 Morphologic, immunologic, and viral DNA studies, 6147 DNA strand initiation sequence of ColEl plasmid: Expression in a Cloned hepatitis B virus DNA: Expression in human cell cultures, 5507 single-stranded DNA phage, 6566 Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences Elongationof primedDNA templates by eukaryoticDNA polymerases, as BamHI fragments, 4201 5827 Codingcapacity of a 35%fragment of polyomavirus genome is sufficient Elongation of primed DNA templates by eukaryotic DNA polymerases to initiate and maintaincellular transformation, 3278 (correction), 7510 5,6-Dichloro-l-/-ribofuranosylbenzimidazoleenhances premature Energy relay: A proofreading scheme based on dynamic cooperativity termination of late transcription of simian virus 40 DNA, 3297 and lacking all characteristic symptoms of kinetic proofreading in DNA replication in vitro of recombinant plasmid DNAs containing the DNA replication and protein synthesis, 5248 origin of progeny replicative form DNA synthesis of phage 4X174, Escherichia coli replication protein that recognizes a unique sequence 5182 within a hairpinregion in ,X174 DNA, 799 Ecotropic proviral sequences: Identification in inbred mouse strains with Eukaryotic DNA segments capable of autonomous replication in yeast, a cloned subgenomicDNA fragment,5779 4559 Epstein-Barrvirus (B95-8) DNA VII: Molecularcloning and detailed Formation of a RNA primer for initiation of replication of ColEl DNA mapping,2999 by ribonucleaseH, 2450 Epstein-Barrvirus genes expressedin differentcell types after Initiation of DNA replication by Escherichia coli dnaG protein: microinjectionof viral DNA, 433 Evidence that tertiary structure is involved, 900 Integratedand free viral DNA in hamstertumors inducedby BK virus, Initiationof DNA replicationin a ColEl-type plasmid:Isolation of 975 mutations in ori region, 6744 Integrationin vivo into simian virus 40 DNA of a sequencethat Isopentenyladenineas a mediatorof mevalonate-regulatedDNA resemblesa certainfamily of genomicinterspersed repeated sequences, replication,5842 4514 Localizationof loci for hypoxanthinephosphoribosyltransferase and Methylation of integrated adenovirus type 12 DNA sequences in glucose-6-phosphatedehydrogenase and biochemicalevidence of transformed cells is inversely correlated with viral gene expression, 253 nonrandom X chromosome expression from studies of a human Molecular cloning of infectious integrated murine leukemia virus DNA X-autosome translocation,2810 from infected mouse cells, 614 Mitogenic hormone-induced intracellular message: Assay and partial Molecular cloning of unintegrated Moloney mouse sarcoma virus DNA in characterizationof activatorof DNA replicationinduced by epidermal bacteriophage X, 1773 growthfactor, 112 Nucleic acid spot hybridization: Rapid quantitative screening of Multienzymecomplex for metabolicchanneling in mammalianDNA lymphoidcell lines for Epstein-Barrviral DNA, 6851 replication, 3312 Nucleotide sequence analysis of transforming region and large terminal Nucleotidesequence of primaryorigin of bacteriphageT7 DNA redundanciesof Moloneymurine sarcoma virus, 5234 replications: Relationship to adjacent genes and regulatory elements, Nucleotide sequenceof Moloneyleukemia virus: 3' End reveals details of 3917 replication,analogy to bacterialtransposons, and an unexpectedgene, Nucleotide sequence of Salmonella typhimurium origin of DNA 3302 replication, 2460 Nucleotide sequences of integrated Moloney sarcoma provirus long Origin of DNA replication of bacteriophage fl as the signal for terminal repeats and their host and viral junctions, 3937 termination, 5226 Originof replicationof DNA of a herpesvirus(pseudorabies), 172 Originof replicationof DNA of a herpesvirus(pseudorabies), 172 Polyoma large tumor antigen is not required for tumorigenesis mediated Pentaribonucleotides of mixed sequence are synthesized and efficiently by viral DNA, 1336 prime de novo DNA chain starts in T4 bacteriophage DNA replication Structureof a cloned circularMoloney murine leukemia virus DNA system, 5698 molecule containing an inverted segment: Implications for retrovirus Plasmid pBR322:Replication under controlof a cloned replicationorigin integration, 3932 from single-stranded DNA phage M13, 4638 Structure of endogenous murine leukemia virus DNA in mouse genomes, Replicationof duplex DNA of phage kX174reconstituted with purified 5774 enzymes, 3322 Downloaded by guest on September 29, 2021 7562 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Structureof Moloneymurine leukemia viral DNA: Nucleotidesequence The cbpA gene:Role of the 26,000-daltoncarbohydrate-binding protein of the 5' long terminalrepeat and adjacentcellular sequences, 3307 in intercellular cohesion of developing Dictyostelium discoideum cells, Synthesis and circularizationof N- and B-tropicretroviral DNA in Fv-l 4788 permissive and restrictive mouse cells, 2994 N,N'-Dicyclohexylcarbodiimide Transformationof rat embryofibroblasts by cloned polyomavirus DNA N,N'-Dicyclohexylcarbodiimidebinds specificallyto a single glutamyl fragmentscontaining only part of the early region,3978 residue of the proteolipid subunit of mitochondrial Tumorigenictransformation induced by specific fragmentof DNA from adenosinetriphosphatasesfrom Neurosporacrassa and Saccharomyces herpes simplex virus type 2, 2279 cerevisiae,785 Viral DNA sequencesin hamstercells transformedby herpes simplex Diethyldithiocarbamate virus type 2, 880 Diethyldithiocarbamaterescue: Effect on tumorresponse to cis-platinum Virus in Beechey ground squirrels that is related to hepatitis B virus of in a rat model, 5441 humans, 2941 Diethyl pyrocarbonate Deoxyribonucleicacid, yeast Chemicalprobes for higher-orderstructure in RNA, 4679 Saccharomycescerevisiae: Autonomously replicating sequences, 6329 Differentialthermal analysis Transposablemating type cassettes in Saccharomycesyeasts: Structure Membrane lipid physical state and modulation of Na+,Mg2+-ATPase and organization,2839 activity in Acholeplasmalaidlawii B, 1255 Deoxyribopyrimidinetriphosphatase Differentiation Deoxyribopyrimidinetriphosphatase activity specific for cells infected see Differentiatin, cell; Membrane differentiation with herpes simplexvirus type 1, 1872 Differentiation,cell 5-bromo- Deoxyuridine, /-Adrenergic receptors: Induction and properties during erythroid Deoxyribonucleotide pools, base pairing, and sequence configuration differentiation of Friend leukemic cells, 4065 affecting bromodeoxyuridine- and 2-aminopurine-induced Amilorideinhibits murineerythroleukemia cell differentiation:Evidence mutagenesis, 1801 for a Ca2+requirement for commitment,5948 Phenotypicevolution of cells resistantto bromodeoxyuridine,4206 Anchorage-independentmuscle cell differentiation,5297 Deoxyuridine5'-monophosphate, fluoro- Chromatinrepeat correlateswith in Mitotic recombinationin length phenotypicexpression yeast: Inductionby starvationfor thymine hepatoma cells, their dedifferentiated variants, and somatic hybrids, nucleotides,6057 3412 Detergent Clonalanalysis of proliferationand differentiationof paireddaughter see also specificdetergents cells:Action of granulocyte-macrophagecolony-stimulating factor on Affinity chromatographyin nonionicdetergent solutions, 5847 granulocyte-macrophageprecursors, 5327 Brain adenylatecyclase: Properties of the separatedcatalytic and Differentialprocessing of subunits of humanchorionic gonadotropin by regulatoryunits, 6344 granulosa cells in vivo, 4793 Nondenaturingzwitterionic detergent for membranebiochemistry: Differentiation of a mammary cell line: Control by lipids, 1551 Design and synthesis,6368 Differentiation of human and murine myeloid leukemia cells induced in Solubilizationof active opiate receptors,4623 culture by tunicamycin, 409 Dexamethasone Differentiation of human promyelocytic leukemia cell line (HL-60): Glucocorticoid hormones increase activity of plasma membrane alkaline Induction by retinoic acid, 2936 I in phosphodiesterase rat hepatoma cells, 1005 Discrete stages of human intrathymic differentiation: Analysis of normal Stress-induced release of prolactin: Blockade by dexamethasone and thymocytesand leukemiclymphoblasts of T-cell lineage, 1588 naloxonemay indicate/-endorphin mediation,666 Embryonalcarcinoma cell line Fg:Growth and differentiationin defined Dextran media, 457 Macromolecular/-adrenergic antagonists discriminating between Endogenouslectin: Distributionand activity duringmyogenesis as receptorand antibody,2219 measured with antilectin antibody, 1054 Dextransulfate Fetal rat liver cell line established that retains differentiated liver Prostaglandinsynthesis by macrophagesrequires a specific functions, 2731 receptor-ligandinteraction, 4279 Fibronectin: Synthesis and localization during collagenous Diabetes matrix-mesenchymal cell interaction and differentiation of cartilage Acetonemetabolism in mice:Increased activity in mice heterozygousfor and bone in vivo, 2074 obesity genes, 290 Hormonal control of human colon carcinoma cell growth in serum-free Alloxan:Enzymatic reduction by thioredoxinand NADPH-thioredoxin medium, 3464 reductase,5149 Inductionof differentiationof murineerythroleukemia cells by Continuous,clonal, insulin- and somatostatin-secretingcell lines aminonucleosideof puromycinand inhibitionof inductionby purines establishedfrom a transplantablerat islet cell tumor,3519 and purinederivatives, 2740 IncreasedATP inhibitionof liver phosphofructokinasefrom genetically Interferon inhibits conversion of 3T3-L1 mouse fibroblasts into diabetic mice, 2497 adipocytes, 4099 Insulin-dependentdiabetes mellitus inducedby subdiabetogenicdoses of Interferon inhibits conversion of 3T3-L1 mouse fibroblasts into streptozotocin:Obligatory role of cell-mediatedautoimmune processes, adipocytes (correction), 6941 6129 Lentropin: A factor in vitreous humor which promotes lens fiber cell Insulin release,insulin sensitivity,and glucoseintolerance, 7425 differentiation, 490 Diabroticitebeetle Molecularcloning of developmentallyregulated, low-abundance mRNA Cucurbitacins as kairomones for diabroticite beetles, 3769 sequencesfrom embryonicmuscle, 4519 Dialuricacid Monoclonalantibodies against trophectoderm-specific markers during Alloxan:Enzymatic reduction by thioredoxinand NADPH-thioredoxin mouse blastocystformation, 4113 reductase,5149 Monoclonal antibodies to sucrase/isomaltase: Probes for study of a,-Diaminobutyric acid postnataldevelopment and biogenesisof intestinal microvillus Cyclicenkephalin analog with high in vitro opiate activity, 7162 membrane, 6629 Diarrhea Myogenesis in vitro: Dependence on a trophic protein present in chicken Nucleotidesequence of bacterialtransposon Tn1681 encodinga embryoextract, 6922 heat-stable(ST) toxin and its identificationin enterotoxigenic Nerve growth factor: Mobility, clustering, and transport in embryonal Escherichia coli strains, 4011 sensory cells and in a sympathetic neuronal cell line, 3469 Phorbolesters induce differentiationin humanmalignant T Diazepamreceptor: Specific nuclear binding of [3H],1195 lymphoblasts,2964 1,3-Dibromo-2-propanone Phorbol 12-myristate 13-acetate: Selective effects on myofibrils and Yeast fatty acid synthetase: Structure-function relationship and nature 10-nm filaments, 5273 of the /-ketoacyl synthetase site, 4544 Poly(ADP-ribose)synthesis, a markerof granulocytedifferentiation, cis-Dichlorodiammineplatinum(II) 3682 Diethyldithiocarbamaterescue: Effect on tumor responseto cis-platinum Potential leukemic cells among bone marrow cells of young AKR/J mice, in a rat model, 5441 2923 Dictyostelium Presumptive common precursor for neuronal and glial cell lineages in Regulationof myosin self-assembly:Phosphorylation of Dictyostelium mouse hypothalamus, 4165 heavy chain inhibits formationof thick filaments,7292 Presumptive common precursor for neuronal and glial cell lineages in Dictyosteliumdiscoideum mouse hypothalamus(correction), 6941 A /-like DNA polymeraseactivity in slime mold Dictyostelium Pyruvatecarboxylase apoenzyme and holoenzyme:Induction in 3T3-L1 discoideum,3317 cells duringdifferentiation, 1321 ATP-drivensteady-state exchange of monomericand filamentousactin Schwanncells proliferatebut fail to differentiatein defined medium, from Dictyosteliumdiscoideum, 4610 6902 Cyclic AMP: A role in expression of developmentally regulated genes in Successiveswitching of antibodyisotypes expressedwithin the lines of a Dictyosteliumdiscoideum, 1044 B-cell clone, 5424 Kinetics of membrane internalization and recycling during pinocytosis in talpid2 mutant of the chickenwith perturbedcartilage development has Dictyosteliumdiscoideum, 1015 an altered precartilage-specificchromatin protein, 4828 Phospholipidmethylation during chemotaxis in Dictyostelium Viralthymidine kinase gene and the human ,/-globingene introduced discoideum:Regulation by guanosine3',5'-cyclic monophosphate, 6996 into developmentally multipotential mouse teratocarcinoma cells, 2098 Protein synthesis: Regulation during spore germination in Dictyostelium Diffusion discoideum,1791 see also Protein diffusion; Reaction-diffusion model Renaturationand localizationof enzymesin polyacrylamidegels: Studies Compositionaldomain structure in phosphatidylcholine-cholesteroland with UDPglucosepyrophosphorylase of Dictyostelium,730 sphingomyelin-cholesterol bilayers, 4055 Scale-invariance in reaction-diffusion models of spatial pattern Fluorescence immunoassay based on long time correlations of number formation,4180 fluctuations, 4904 Downloaded by guest on September 29, 2021 Proc. 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Lateraldiffusion of membranelipids and proteinsduring cell cycle of Inductionof translatablemRNA for dopa decarboxylasein Drosophila: neuroblastomacells, 1526 Early response to ecdysterone, 4175 Lateralmobility of band 3 in human erythrocytemembrane studied by Juvenile hormone-bindingprotein from the cytosol of DrosophilaKc fluorescencephotobleaching recovery: Control by cytoskeletal cells, 4657 interactions,2537 Membrane electrical excitability in Drosophila: Facilitation, 6216 Liposomes:Fusion with mitochondrialinner membranes,442 Molecularanalysis of a gene in a developmentallyregulated puff of Membraneprotein lateral mobility: Modulation by polyphosphatesand Drosophilamelanogaster, 7362 polyamines, 1457 Molecular limits on size of a genetic locus in Drosophila melanogaster, Nerve growth factor: Mobility, clustering, and transport in embryonal 7367 sensory cells and in a sympathetic neuronal cell line, 3469 Quantitativegenetic variationof enzyme activities in naturalpopulations Digitalis of Drosophilamelanogaster, 1073 Digitalis metabolismand humanliver alcoholdehydrogenase, 924 Relationshipsamong chromatid interchanges, sister chromatid Digitonin exchanges,and meiotic recombinationin Drosophilamelanogaster, Cytoskeleton of digitonin-treated rat hepatocytes, 3430 1575 Dihydroergocryptine Ribosomalproteins: Expression during Drosophila early development, Agonist versus antagonist binding to a-adrenergic receptors, 4569 5649 Dihydrofolatereductase RNA encodedby eukaryotictransposable element copia: Translation see Tetrahydrofolate dehydrogenase and developmental regulation, 7107 Selection for viability at loci controlling protein polymorphisms in Phylogenyof sex steroid binding plasmaprotein: Hormonal and Drosophila melanogaster is very weak at most, 4857 immunologicalaspects, 4578 Site specificityof mutationsarising in dysgenichybrids of Drosophila p-Dimethylaminobenzenediazonium fluoroborate melanogaster,6042 Specific photoaffinitylabeling induced by energytransfer: Application to Untranslated mRNA for a chorion protein of Drosophila melanogaster irreversibleinhibition of acetylcholinesterase,6439 accumulates transiently at onset of specific gene amplification, 5789 Dimethylformamide Drug Developmentof chemotacticresponsiveness in myeloid precursorcells: see also Chemotherapy;Deoxyribonucleic acid-drug interaction; specific Studies with a human leukemia cell line, 3664 drugs Dimethylglycinedehydrogenase (EC 1.5.99.2) Drug deliverysystem Folate bindingprotein of mitochondriaidentified as dimethylglycine Targetingof lipid vesicles:Specificity of carbohydratereceptor analogues dehydrogenase,4484 for leukocytesin mice, 4430 Dimethyl sulfate Drug,macromolecular form Chemicalprobes for higher-orderstructure in RNA, 4679 Macromolecular/-adrenergic antagonists discriminating between Effect of introduction of small alkyl groups on mRNA function, 1983 receptorand antibody,2219 Dimethyl sulfoxide Drug, psychotropic Activation of human f-globin genes from nonerythroid cells by fusion Dlazepam receptor: Specific nuclear binding of [3H]flunitrazepam, 1195 with murineerythroleukemia cells, 3435 Dye Amilorideinhibits murineerythroleukemia cell differentiation:Evidence X-ray structureof a cytidylyl-3',5'-adenosine-proflavinecomplex: A for a Ca2+ requirement for commitment, 5948 self-pairedparallel-chain double helical dimer with an intercalated Reversible translocation of cytoplasmic actin into the nucleus caused by acridinedye, 1852 dimethyl sulfoxide, 5268 Dynamicrandom-dot correlogram 2,3-Diphosphoglycerate Largeevoked potentials to dynamicrandom-dot correlograms and Membraneprotein lateral mobility:Modulation by polyphosphatesand stereogramspermit quick determinationof stereopsis,2348 polyamines,1457 Dynorphin Discoidin I Immunoreactivedynorphin in pituitaryand brain,6207 Change in rate of transcription of a eukaryotic gene in response to cyclic AMP, 7171 Ecdysone Disease, aggregation Molecularanalysis of a gene in a developmentallyregulated puff of Test for randomness of occurrence of a disease trait in familial or other Drosophilamelanogaster, 7362 similarordered sequences of epidemiologicaldata, 2974 Ecdysterone Dolichyldiphosphoryloligosaccharide-proteinoligosaccharyltransferase Ecdysteronelocalized on polytene chromosomesof Drosophila Dolichyldiphosphoryloligosaccharide-proteinoligosaccharyltransferase: melanogaster,2108 Solubilization,purification, and properties,3811 Inductionof translatablemRNA for dopa decarboxylasein Drosophila: Dopa decarboxylase Early responseto ecdysterone,4175 see Aromatic-L-amino-aciddecarboxylase Ecology Brain size and ecologyin small mammalsand primates,4387 Dopamine and depolarizing agents regulate state of phosphorylation of Ecological and evolutionary significance of mycorrhizal symbioses in protein I in mammalian superior cervical sympathetic ganglion, 7479 vascularplants (A Review),2113 Locomotoractivation induced by infusionof endorphinsinto ventral L-Glutamicacid as a mediatorof sexual morphogenesisin Volvox tegmentalarea: Opiate-dopamine interactions, 2323 capensis, 1025 Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions, 4305 Electron spin resonance of 170-labeled protein-peroxide radicals: Zein Dopamine,5-hydroxy- and edestin, 343 Synapticendings and their postsynaptictargets in neostriatum:Synaptic EDTA specializationsrevealed from analysisof serial sections, 6926 see Ethylenediaminetetraacetic acid Dopamine,-hydroxylase Egg-layinghormone see Dopamine/-monooxygenase Two neuroactivepeptides that cause bag cell afterdischargeand Dopaminef-monooxygenase (EC 1.14.17.1) egg-laying in Aplysia: Purification and primary structure, 2328 Catecholaminebiosynthetic enzymes are expressedin replicatingcells of Electricalcurrent peripheralbut not centralnervous system, 6221 Currentrecorded from a cut-open.giantaxon under voltage clamp, 7484 Down syndrome Endogenous electrical currents in water mold Blastocladiella emersonii Genes coding for sensitivity to interferon(IfRec) and soluble superoxide duringgrowth and sporulation,6673 dismutase (SOD-1) are linked in mouse and man and map to mouse Large and persistent electrical currents enter transected lamprey spinal chromosome 16, 2168 cord, 1209 Drosophilamelanogaster Large and persistent electrical currents enter transected lamprey spinal Circadianrhythm mutations in Drosophilamelanogaster affect cord (correction), 4390 short-termfluctuations in male's courtshipsong, 6729 Magnetic fields produced by steady currents in the body, 1447 DNA polymerasea mutants from a Drosophilamelanogaster cell line, Single channel currents from excised patches of muscle membrane, 6930 7049 Electricalexcitability DNA-protein interactionsin Drosophilamelanogaster mitochondrial Electricalexcitability: Spectrum of propertiesin progenyof a single genomeas deducedfrom trimethylpsoralencrosslinking patterns, 4118 embryonic neuroblast, 1676 Drosophila dehydrogenase gene: Isolation and partial Electrical excitability: Spectrum of properties in progeny of a single characterization,5794 embryonic neuroblast (correction), 4390 Drosophila DNA-binding protein DB-2: Demonstration of its Membraneelectrical excitability in Drosophila:Facilitation, 6216 sequence-specificinteraction with DNA, 3773 Electrochemicalgradient Drosophilanucleosomes contain an unusualhistone-like protein, 2671 Electrochemical proton gradient generated in Streptococcus cremoris by Ecdysteronelocalized on polytene chromosomesof Drosophila lactate efflux, 5502 melanogaster,2108 Electrode,living Enzyme null alleles in natural populations of Drosophila melanogaster: "Livingelectrode" as a long-livedphotoconverter for biophotolysisof Frequencies in a North Carolina population, 1091 water, 2442 Four heat shock proteinsof Drosophilamelanogaster coded within a Electrolectin 12-kilobaseregion in chromosomesubdivision 67B, 5390 Endogenouslectin: Distributionand activity duringmyogenesis as Genes for chorionproteins: Amplification during oogenesis in Drosophila measured with antilectin antibody, 1054 melanogaster,1096 Electronmicroscopy Genes for three Drosophilaheat-shock-induced proteins at a single locus, Assembly of subcomponents Clr and Cls of first component of 2134 complement: Electron microscopic and ultracentrifugal studies, 7014 Immunoreactive helix-destabilizing protein localized in transcriptionally Compositionof native and reconstitutedchromatin particles: Direct active regionsof Drosophilapolytene chromosomes,6749 mass determinationby scanningtransmission electron microscopy, Increasedmutation in crossesbetween geographically separated strains 4818 of Drosophilamelanogaster, 1059 Downloaded by guest on September 29, 2021 7564 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

DNA-protein interactions in Drosophila melanogaster mitochondrial Endoplasmicreticulum genome as deduced from trimethylpsoralen crosslinking patterns, 4118 Coatedvesicles transportnewly synthesizedmembrane glycoproteins Electron micrographs of negatively stained protein molecules: Fidelity of from endoplasmicreticulum to plasmamembrane in two successive structure representation, 4721 stages, 780 Electronmicroscopy of negativelystained and unstainedfibrinogen, 3139 Crystallineribosomes are presentin brainsfrom senile humans,2260 Kinetics of fiber-to-crystal transition of sickle cell hemoglobin: Electron CytochromeP-450: Synthesis and insertioninto endoplasmicreticulum microscope study, 944 membranes,965 Membrane-bound acetylcholine receptor from Torpedo marmorata: Membrane-associatedprotein complex required for proteintranslocation Structural details, 952 acrossendoplasmic reticulum: Purification, 7112 Optimal imaging techniques in scanning transmission electron Pyrophosphate:proteinphosphotransferase: Membrane-bound enzyme of microscope: Applications to biological macromolecules, 4051 endoplasmicreticulum, 1927 Electronparamagnetic resonance Endorphin Copperelectron-nuclear double resonanceof cytochromec oxidase,1452 Humanleukocyte interferon: Structural and biologicalrelatedness to Cytochrome oxidase: An alternative model, 1806 adrenocorticotropichormone and endorphins,5972 Electron paramagnetic resonance spectroscopy of Cu2+ in hen egg-white Locomotoractivation induced by infusionof endorphinsinto ventral lysozyme, 5243 tegmentalarea: Opiate-dopamine interactions, 2323 Interactionbetween the intermediaryelectron acceptor (pheophytin) and ,-Endorphin a possible plastoquinone-ironcomplex in photosystemII reaction Biosynthesisof precursorcorticotropin/endorphin-, corticotropin-, centers,7227 a-melanotropin-,/-lipotropin-, and /-endorphin-likematerial by Triplet states in photosystemI of spinachchloroplasts and culturedneonatal rat hypothalamicneurons, 1880 subchloroplast.particles(correction), 1229 Brain regulationof gastricsecretion: Influence of neuropeptides,5515 Electronspin resonance /-Endorphin:Characteristics of bindingsites in rabbitspinal cord, 5746 Chargeselectivity at lipid-proteininterface of membranous /-Endorphin:Dissociation of receptorbinding activity from analgesic Na,K-ATPase,272 potency,2303. Electronspin resonanceof 170-labeledprotein-peroxide radicals: Zein /f-Endorphinomission analogs: Dissociation of immunoreactivityfrom and edestin, 343 other biologicalactivities, 3211 Electrontransfer ,-Endorphin:Stability, clearance behavior, and entry into the central see also Transport, electron nervoussystem after intravenousinjection of the tritiated peptide in Crystallization of middle part of mitochondrial electron transfer chain: rats and rabbits,4588 Cytochrome bcl-cytochrome c complex, 5084 Morphineand opioid peptides reduceparaventricular neuronal activity: Crystallizationof part of the miotchondrialelectron transfer chain: Studies on rat hypothalamicslice preparation,5527 Cytochromec oxidase-cytochromec complex,928 Peptide inhibitorof morphine-and P-endorphin-inducedanalgesia, 5525 Enzymiccatalysis and energycoupling: Relationship, 5703. Stress-inducedrelease of prolactin:Blockade. by dexamethasoneand Liposomes:Fusion with mitochondrialinner membranes,442 naloxonemay indicate/-endorphin mediation,666 Physical interactionand activity couplingbetween two enzymesinduced t-Endorphin-likepeptide by immobilization of one, 249 /-Endorphin-likepeptides from bovine brains:Isolation and Redox conformation changes in refined tuna cytochrome c, 6371 characterization,230 Electrontunneling Endplatecurrent Electrontunneling process and segmentmobility of macromolecules, see also Miniatureendplate current 7218 Attempt to distinguishbetween actions of neuromuscularblocking drugs Electrophoresis on the acetylcholinereceptor and on its associatedionic channel,5003 Humanlysosomes can be purifiedfrom diploid skin fibroblastsby [3H]:Probe for ionic channelof nicotinicreceptor, 7458 free-flow electrophoresis, 6139 Endproductinhibition Sequenceof 1060 3'-terminalnucleotides of poliovirusRNA as Regulationof hexosaminebiosynthetic pathway in watermold determined by a modification of the dideoxynucleotide method, 3196 Blastocladiellaemersonii: Sensitivity to endproductinhibition is Electrophoruselectricus dependentupon life cycle phase, 5998 Acetylcholine receptor-controlled ion translocation across cell Energycoupling membranes: Molecular mechanism, 842 Enzymiccatalysis and energycoupling: Relationship, 5703 Charge selectivity at lipid-protein interface of membranous Energyreserve. Na,K-ATPase, 272 Populationoscillations and energyreserves in planktoniccladocera and Ouabain-binding-site photoaffinity probes that label both subunits of their consequencesto competition,1716 Na+,K+-ATPase, 4529 Energy,solar Electrophysiology "Livingelectrode" as a long-livedphotoconverter for biophotolysisof Impulse activity of locus ceruleus neurons in awake rats and monkeys is water,2442 a function of sensory stimulation and arousal, 3033 Energy.transfer Elongationfactor Chloroplastphosphoproteins: Regulation of excitationenergy transfer by Elongation factor Tu from Escherichia coli: Primary structure, 1326 phosphorylationof thylakoidmembrane polypeptides, 5253 Elongation factor Tu isolated from Escherichia coli mutants altered in Energytransfer between photosystem II units in a connectedpackage tufA and tufB, 3922 model of the photochemicalapparatus of photosynthesis,4697 Hydrolysis of GTP on elongation factor Tu-ribosome complexes Specificphotoaffinity labeling induced by energytransfer: Application to promoted by 2'(3')-O-L-phenylalanyladenosine, 905 irreversibleinhibition of acetylcholinesterase,6439 Posttranslational modification of elongation factor 2 in Enkephalin diphtheria-toxin-resistant mutants of CHO-KI cells, 1010 see also Receptor,enkephalin RNA polymeraseactivity: Inhibition by Escherichiacoli protein Analgesicactivity of naturallyoccurring heptapeptide biosynthesiselongation factor Ts, 866 [Met]enkephalin-Arg6-Phe7,5512 Embryogenesis Cyclicenkephalin analog with high in vitro opiate activity, 7162 Growing optic nerve fibers follow neighbors during embryogenesis, 4374 Differentiationof I- and ,-opiate receptorlocalizations by light Embryo,mouse microscopicautoradiography, 6239 Genetictransformation of mouse embryosby microinjectionof purified Enkephalinand fear-motivatedbehavior, 3729 DNA, 7380 Enkephalinbiosynthetic pathway: Proteins of 8000 and 14,000daltons in Endocytosis bovine adrenalmedulla, 5018 Coatedpits act as molecularfilters, 4156 Enkephalinsand enkephalin-containingpolypeptides: Release from Nerve growthfactor: Mobility, clustering, and transportin embryonal perfusedbeef adrenalglands, 7423 sensorycells and in a sympatheticneuronal cell line, 3469 Guineapig intestinal electrolytesecretion: Control by a b-opiate Proteins iodinatedby chloramine-Tmethod appearto be degradedat an receptor,2753 abnormallyrapid rate after endocytosis,1556 Morphineand opioid peptides reduceparaventricular neuronal activity: Receptor-mediatedendocytosis of antibody-opsonizedliposomes by Studies on rat hypothalamicslice preparation,5527 tumor cells, 4089 Probableprecursors of [Leu]enkephalinand [Met]enkephalinin adrenal Receptor-mediateduptake of 3,3',5-triiodo-L-thyronineby cultured medulla:Peptides of 3-5 kilodaltons,1681 fibroblasts,3425 Selective protectionof stereospecificenkephalin and opiate binding Transglutaminase:Participation in receptor-mediatedendocytosis, 2706 against inactivationby N-ethylmaleimide:Evidence for two classes of EndodeoxyribonucleaseBamHI (EC 3.1.23.6) opiate receptors,281 Cloning and mapping of BamHI endonuclease fragments of DNA from Studies with [35S]methionineindicate that the 22,000-dalton transformingB95-8 strain of Epstein-Barrvirus, 3860 [Met]enkephalin-containingprotein in chromaffincells is a precursor Cloning and mapping of BamHI endonuclease fragments of DNA from of [Met]enkephalin,6889 the transformingB95-8 strain of Epstein-Barrvirus (correction),7510 Synthesis of enkephalinsby adrenalmedullary chromaffin cells: Endonuclease Reserpineincreases incorporation of radiolabeledamino acids, 4364 see also Restriction endonuclease Enolase (EC 4.2.1.11) Apurinic/apyrimidinic in repair of pyrimidine dimers and Altered enolase in aged Turbatrix aceti results from conformational other lesions in DNA, 4602 changes in the enzyme, 5865 Endonuclease isolated from Epstein-Barr virus-producing human Entropyof activation lymphoblastoid cells, 6194 Conformationalchanges during enzyme catalysis: Role of water in the EndonucleaseS1 transition state, 3374 Expressionof early genes of origin-defectivemutants of simian virus 40, Enucleation 3898 Alternative method for identifying reconstituted cells, 381 Invertedrepeat as a recognizablestructural feature in supercoiledDNA Enzooticbovine leukosis molecules,6468 Genomic integration of bovine leukemia provirus: Comparison of Targeteddeletions of sequencesfrom closed circularDNA, 2455 persistent lymphocytosis with lymph node tumor form of enzootic bovine leukosis, 2577 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7565

Enzymecatalysis Erythropoietin see also Michaelis-Mentenkinetics; specific enzymes Proportionof fetal hemoglobinsynthesis decreasesduring erythroid cell Conformationalchanges during enzyme catalysis: Role of water in the maturation,2757 transitionstate, 3374 Escherichiacoli Enzymiccatalysis and energycoupling: Relationship, 5703 Amino-terminalsequence and processingof precursorof leucine-specific Enzymekinetics bindingprotein, and evidence for conformationaldifferences between CarboxypeptidaseA, in supercooledwater: Structure and function, 132 precursorand matureform, 2005 Subunit neighborinteractions in enzyme kinetics:Half-of-the-sites Attractantsand repellentscontrol demethylation of methylated reactivityin a dimer, 5741 chemotaxisproteins in Escherichiacoli (correction),2353 Enzymemechanism Autogenouscontrol of Escherichiacoli ribosomalprotein L10 synthesis Carboxybiotintranslocation mechanisms suggested by diffractionstudies in vitro, 2592 of biotin and its vitamers,333 BacteriophageX vehicle for direct cloningof Escherichiacoli promoter Conventionalassumption of internalequilibrium within the states of a DNA sequences:Feedback regulation of rplJL-rpoBCoperon, 2124 biochemicalcycle: Examination, 205 ClonedDNA containinggenes responsiblefor branched-chainamino acid Eosin transportin Escherichiacoli: Structuraland functionalanalysis, 1412 Oligosaccharidemotion in erythrocytemembranes investigated by Cloningof active thymidinekinase gene of herpes simplex virus type 1 in picosecondfluorescence polarization and microseconddichroism of an Escherichiacoli K-12 (correction),4390 optical probe,5899 Completenucleotide sequence of 23S ribosomalRNA gene from Epidemiology Escherichiacoli, 201 Test for randomnessof occurrenceof a disease trait in familialor other CyclicGMP: Involvement in intracellularsignaling in chemotactic similarordered sequences of epidemiologicaldata, 2974 responseof Escherichiacoli, 3879 Epidermalgrowth factor-urogastrone Direct transferof cloned genes from bacteriato mammaliancells, 2163 Epidermalgrowth factor-urogastrone and its receptor:Detection during DNA sequenceencoding NH2-terminal peptide involved in transportof X fetal mouse development,2782 receptor,an Escherichiacoli secretoryprotein, 2621 Epidermis Donor insertionsequence IS1: Fate duringtransposition, 2514 Differentiallectin bindingto cellularmembranes in epidermisof Elongationfactor Tu from Escherichiacoli: Primarystructure, 1326 newbornrats, 477 Escherichiacoli L-arabinoseoperon: Binding sites of regulatoryproteins Receptor-likeprotein for 1,25-dihydroxyvitaminD3 in rat skin: and a mechanismof positive and negativeregulation, 3346 Characterization,5822 Escherichiacoli lexA protein:Cleavage by the recA protease,3225 Epididymis Escherichiacoli RNA polymerasein vitro mimics simian virus 40 in vivo Sex steroid-bindingprotein of plasma:Immunocytochemical localization transcriptionwhen the template is viral nucleoprotein,6556 in tissues of adult monkeyMacaca nemestrina,5678 Eukaryoticsignal sequencetransports insulin antigen in Escherichia Epigenesis coli, 3369 Translationof epigeneticrules of individualbehavior into ethnographic Expression from glnA promoter of Escherichia coli: Regulation in patterns,4382 absenceof glutaminesynthetase, 7372 Epilepsy Feedbackregulation of ribosomalprotein gene expressionin Escherichia Repeatedseizures induce long-termincrease in hippocampal coli, 3590 benzodiazepinereceptors, 3029 Feedbackregulation of ribosomalprotein gene expressionin Escherichia Epinephrine coli: Structural homology of ribosomal RNA and ribosomal' protein Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: mRNA, 7084 Action on proteinphosphatase(s) and its inhibitor(s),5711 Genetic recombinationof bacterialplasmid DNA: Electronmicroscopic Agonistversus antagonistbinding to a-adrenergicreceptors, 4569 analysis of in vitro intramolecular recombination, 4847 Epstein-Barrvirus Inhibitionof initiationof translationby a factor isolated from see also Receptor,Epstein-Barr virus Escherichiacoli cells, 1181 Acyclovirinhibition of Epstein-Barrvirus replication,5163 Metabolite gene regulation of L-arabinose operon in Escherichia coli Appearanceof cytoskeletalcomponents on the surfaceof leukemiacells with indoleaceticacid and other indole derivatives,1768 and of lymphocytestransformed by mitogensand Epstein-Barrvirus, Multivalenttranslational control of transcriptiontermination at 4979 attenuatorofilvGEDA operonof Escherichiacoli K-12, 1862 Cloningand mappingof BamHI endonucleasefragments of DNA from Novel histone H2A-likeprotein of Escherichiacoli, 5097 transformingB95-8 strain of Epstein-Barrvirus, 3860 Nucleotide sequence and expression of Escherichia coli trpR, structural Cloningand mappingof BamHI endonucleasefragments of DNA from gene for trp aporepressor,.7117 the transformingB95-8 strain of Epstein-Barrvirus (correction),7510 Nucleotide sequence of bacterial transposon Tn1681 encoding a Endonucleaseisolated from Epstein-Barrvirus-producing human heat-stable (ST) toxin and its identification in enterotoxigenic lymphoblastoidcells, 6194 Escherichia coli strains, 4011 Epstein-Barrvirus (B95-8) DNA VII: Molecularcloning and detailed Nucleotidesequence of ilvGEDAoperon attenuator region of mapping,2999 Escherichiacoli, 1823 Epstein-Barrvirus genes expressedin differentcell types after Nucleotidesequence of thrA gene of Escherichiacoli, 5730 microinjectionof viral DNA, 433 Organization of unc gene cluster of Escherichia coli coding for Frequencyand levels of antibodiesto Epstein-Barrvirus-specific DNase proton-translocatingATPase of oxidativephosphorylation, 7005 are elevated in patients with nasopharyngealcarcinoma, 6162 Overlappinggenes at cheA locus of Escherichiacoli, 5370 HLA antigen-relatedrestriction of T lymphocytecytotoxicity to Plasmid ColEl: Sequence-specific recombination, 6724 Epstein-Barrvirus, 4247 Proton-coupled conformational switch of Escherichia coli 5S ribosomal Monoclonalantibodies against majorglycoprotein (gp350/220) of RNA, 3360 Epstein-Barrvirus neutralizeinfectivity, 5307 Replication of plasmids from Staphylococcus aureus in Escherichia coli, Monoclonalantibody against a 250,000-daltonglycoprotein of 7333 Epstein-Barrvirus identifies a membraneantigen and a neutralizing RNA from the rplJL-rpoBC transcription unit of Escherichia coli: antigen;2979 Attenuationand processing,3331 Nucleic'acid spot hybridization:Rapid quantitativescreening of Sequencesof recA gene and protein,2611 lymphoidcell lines for Epstein-Barrviral DNA, 6851 Stimulatoryeffect of low ATP pools on transportof purine nucleosides Errorcatastrophe theory in cells of Escherichiacoli, 2519 Protein synthetic errorsdo not increaseduring aging of culturedhuman Structuralstudies of methyl-acceptingchemotaxis proteins of fibroblasts,1885 Escherichiacoli: Multiplemethylation sites, 2434 Erythrocyte Tetracycline:Active efflux encodedby four geneticallydifferent see also Membrane,erythrocyte tetracyclineresistance determinants in Escherichiacoli, 3974 Abnormalnet Na+ and K+ fluxes in erythrocytesof three varietiesof Two Escherichiacoli factor Y effector sites identified near originsof geneticallyhypertensive rats, 4283 replicationof plasmidsColEl and pBR322,6521 Antisicklingactivity of amino acid benzyl esters, 181 Escherichiacoli chromosome Chloride-activatedpassive potassiumtransport in humanerythrocytes, BacteriophageMu: Integrationat host chromosomalreplication forks 1711 duringlytic development,2801 DeoxyhemoglobinS polymer:Determination in sickle erythrocytesupon Copy-numbermutants of plasmidcarrying replication origin of deoxygenation,5487 Escherichiacoli chromosome:Evidence for a control regionof Erythrocytecholine concentrationsare elevated in manic patients, 6144 replication,3993 Glutathionetransport by inside-outvesicles from humanerythrocytes, DNA-damaging agents stimulate gene expression at specific loci in 6359 Escherichiacoli, 2819 Permeabilizationof animalcells for kinetic studies of intracellular DNA gyraseon the bacterialchromosome: Possibility of two levels of enzymes:In situ behaviorof glycolyticenzymes of erythrocytes,6324 action, 6879 Proteolyticallyresistant domains of humanerythrocyte spectrin: Mu-containing plasmids: Association with Escherichia coli chromosome Identification,5673 upon prophageinduction, 1778 Sickle-cell hemoglobin: Fall in osmotic pressure upon deoxygenation, recA gene of Escherichia coli: Organization, 313 4310 Replicationorigin complex isolated from Escherichiacoli, 262 Synthetic glycolipids: Functional incorporation into cells, 2510 Escherichiacoli F sex factor Erythroidprecursor Chromosomalmutations of Escherichiacoli that alter expressionof Kinetics of erythroidprecursors -in mice infected with anemic or conjugativeplasmid functions, 513 polycythemicstrain of Friend leukemiavirus, '2054 Recombination genes on Escherichia coli sex factor specific for Erythromycin transposableelements, 2814 Posttranscriptionalmodification of mRNA conformation:Mechanism Supercoilsin-prokaryotic DNA restrainedin vivo, 1331 that regulates erythromycin-induced- resistance, 7079 Transposition of Escherichia coli insertion element yaIgenerates a Posttranscriptional regulation of an erythromycin resistance protein five-base-pairrepeat (correction),689 specified by plasmid pE194, 3903 Downloaded by guest on September 29, 2021 7566 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Escherichiacoli membrane tRNA evolution: Convergence and minimal mutation criteria for Phospholipids:Translocation from inner to outer membraneof evaluating early events, 2791 Escherichiacoli, 1867 Exothermicreaction Primarystructure of majorouter membraneprotein II* (ompAprotein) Exothermic process associated with in vitro polymerization of brain of Escherichiacoli K-12, 4592 tubulin, 4425 Regulatoryregion of gene for ompAprotein, a majorouter membrane ExotoxinA protein of Escherichiacoli, 3845 Vimentin filament organization in monkey kidney CV-1 cells: Specific Specificityof diffusionchannels produced by Xphage receptorprotein of disruption by diphtheria toxin, exotoxin A, and cycloheximide, 7267 Escherichiacoli, 167 Extracellularmatrix Specific labelingof lac carrierprotein in membranevesicles of Permissive effect of extracellular matrix on cell proliferation in vitro, Escherichiacoli by a photoaffinityreagent, 6319 4094 Synthesis and maturationof Xreceptor in Escherichiacoli K-12:In vivo Eye and in vitro expressionof gene lamB under lac promotercontrol, 1491 see also Cataract; Cornea; Lens; Retina Escherichiacoli mutant Adrenergic regulation of intraocular pressure: Identification of Cataboliterepression in Escherichiacoli mutants lackingcyclic AMP /2-adrenergic-stimulated adenylate cyclase in ciliary process receptorprotein, 5799 epithelium, 7420 Cell-freecoupled transcription-translation system for investigationof Ionizing radiation: Differential effects on circadian oscillator and other linearDNA segments,7029 functions in eye of Aplysia, 5542 Cellulardivision in Escherichiacoli: Isolationand characterizationof Macular corneal dystrophy: Failure to synthesize a mature keratan penicillin-bindingproteins 1A, 1B, and 3, 4499 sulfate proteoglycan, 3705 Elongationfactor Tu isolated from Escherichiacoli mutants alteredin Eye band tufA and tufB, 3922 Right and left eye bands in frogs with unilateraltectal ablations,2314 Escherichiacoli mutatormutants deficient in methylation-instructed Eyringrate theory DNA mismatch-correction,1063 Conventional assumption of internal equilibrium within the states of a Evolutionof a new enzymaticfunction by recombinationwithin a gene, biochemical cycle: Examination, 205 3529 Rate theory calculation of gramicidin single-channel currents using Prokaryotichistone-like protein interactingwith RNA polymerase,3548 NMR-derived rate constants, 2028 Estradiol Eyring-Stoversurvival theory see also Receptor,estradiol Eyring-Stover survival theory: Application to soil-related functions, 3767 Cellularand subcellularlocalization of 1,25-(OH)2-vitaminD3 in rat kidney:Comparison with localizationof parathyroidhormone and Facteurthymique serique estradiol,1149 see Serum thymic factor 16a-[125I]Iodoestradiol:Interaction with estrogenreceptor and other FactorB steroid-bindingproteins, 328 Partial sequence of human complement component factor B: Novel type Monoclonalantibodies to estrophilin:Probes for study of estrogen of serine protease, 4923 receptors,157 FactorD Phylogenyof sex steroid bindingplasma protein: Hormonal and Human factor D: Active site amino acid sequence, 4938 immunologicalaspects, 4578 Partial amino acid sequence of human factor D: Homology with serine Radiometricanalysis of biologicaloxidations in man:Sex differencesin proteases, 1116 estradiolmetabolism, 4957 FactorVIII Estradiol-2-hydroxylase Factor VIII antigen in von Willebrand disease: Structural analysis, 6832 Opiateregulation of estradiol-2-hydroxylasein brainsof male rats: Familialdysautonomia Mechanismfor controlof pituitaryhormone secretion, 2574 Altered nerve growth factor in fibroblasts from patients with familial Estrogen dysautonomia, 1154 see also Receptor,estrogen; specific estrogens Familialdysbetalipoproteinemia Controlof growthof estrogen-sensitivecells: Role for a-fetoprotein,2084 Isoproteinspecificity in hepatic uptake of apolipoproteinE and Estrouscycle pathogenesis of familial dysbetalipoproteinemia, 4349 Blockadeof recruitmentof ovarianfollicles by suppressionof secondary Familialhypercholesterolemia surgeof follicle-stimulatinghormone with porcinefollicular fluid, 4953 Platelet-derivedgrowth factor stimulates low density lipoprotein Ethnography receptor activity in cultured human fibroblasts, 5962 Gene-culturetranslation in avoidanceof sibling incest, 6248 Fasciationdisease Translationof epigeneticrules of individualbehavior into ethnographic Cytokininproduction, presence of plasmids,and fasciationcaused by patterns,4382 strainsof Corynebacteriumfascians, 619 Ethylenediaminetetraaceticacid Fatty acid Ligandsubstitution reaction of metallothioneinswith EDTA and Fatty acid-requiring mutant of Saccharomyces cerevisiae defective in apo-carbonicanhydrase, 6334 acetyl-CoA carboxylase, 1814 N-Ethylmaleimide Model for capping derived from inhibition of surface receptor capping by Membrane-associatedprotein complexrequired for proteintranslocation free fatty acids, 437 acrossendoplasmic reticulum: Purification, 7112 Regulationof acetyl-CoAcarboxylase: Properties of CoAactivation of Selective protectionof stereospecificenkephalin and opiate binding acetyl-CoA carboxylase, 3351 against inactivationby N-ethylmaleimide:Evidence for two classes of Fatty acid cyclooxygenase opiate receptors,281 see Prostaglandin synthase Ethyl methanesulfonate Fatty acid synthetase DNA polymerasea mutants from a Drosophilamelanogaster cell line, Yeast fatty acid synthetase: Structure-function relationship and nature 7049 of the f-ketoacyl synthetase site, 4544 Eusociality Feces Evolutionof eusocialityin termites (correction),3070 Fecalase: A model for activation of dietary glycosides to mutagens by Evokedcortical potential intestinal flora, 4961 Largeevoked potentials to dynamicrandom-dot correlograms and Fermentation stereogramspermit quick determinationof stereopsis,2348 Electrochemical proton gradient generated in Streptococcus cremoris by Evolution lactate efflux, 5502 Alkalinephosphatase loci: Expressionin mammaliantissues, 2857 Ferredoxin Averagetime until fixation of a mutant allele in a finite population Contrasts between oxygenic and anoxygenic photoreduction of undercontinued mutation pressure: Studies by analytical,numerical, ferredoxin: Incompatibilities with prevailing concepts of and pseudo-samplingmethods, 522 photosynthetic electron transport, 2676 Biologicalcompetition: Decision rules, pattern formation,and Iron-sulfur proteins: Spin-coupling model for three-iron clusters, 6574 oscillations,2338 a-Fetoprotein Density-dependentselection in a randomenvironment: An evolutionary Control of growth of estrogen-sensitive cells: Role for a-fetoprotein, 2084 processthat can maintainstable populationdynamics, 7501 a-Fetoprotein gene in the mouse: Structure, 1351 Diffusionmodel for genotype-dependentmigration, 4842 a-Fetoprotein: Inhibitory effect on binding of myasthenia gravis Duplicatedcytosolic malate dehydrogenasegenes in Zea mays, 4866 antibody to acetylcholine receptor, 3635 Evolutionof a new enzymaticfunction by recombinationwithin a gene, Serum protein production in hepatocyte hybridomas: Immortalization 3529 and expressionof normalhepatocyte genes, 6616 Evolutionof recombinationin a constant environment,4838 Fibrin Exons encode functionaland structuralunits of chickenlysozyme, 5759 Four different polymerization sites involved in human fibrin formation, Genetic exchangesamong ribosomal genes on nonhomologous 1374 chromosomesin man and apes: Molecularevidence, 7323 Fibrinogen Mycoplasmas:Phylogenetic analysis, 494 Fibrinogen: Cleavage by human neutrophil neutral peptide-generating Originsof metabolicdiversity: Substitution of homologoussequences protease, 5448 into genes for enzymeswith differentcatalytic activities,5365 Human plasma fibrinogen heterogeneity: An extended carboxyl-terminal Polymorphism in mitochondrial DNA of humans as revealed by sequence in a normal y chain varient (y'), 5069 restriction endonuclease analysis, 3605 Fibroblast Rapid duplication and loss of genes coding for a chains of hemoglobin, Active proliferationof Rous sarcomavirus-infected, but not normal, 2158 chicken heart mesenchymal cells in culture medium of physiological Selective amplification of variants of a complex repeating unit in DNA of composition, 6606 a crustacean, 2786 Altered nerve growth factor in fibroblasts from patients with familial "Sexual" behavior in parthenogenetic lizards (Cnemidophorus), 499 dysautonomia, 1154 Species near its equilibrium size in a fluctuating environment can evolve Association of the src gene product of Rous sarcoma virus with a lower intrinsic rate of increase, 7497 cytoskeletal structures of chicken embryo fibroblasts, 3484 Autonomous movements of cytoplasmic fragments, 6639 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7567

Cell cycle regulation of dihydrofolate reductase mRNA metabolism in Glycosaminoglycansthat bind cold-insolubleglobulin in cell-substratum mouse fibroblasts, 5140 adhesionsites of murinefibroblasts, 6662 Cellulargenes: Activation by avian RNA tumorviruses, 5351 Thrombinincreases expression of fibronectinantigen on platelet surface, Collagen-hydroxyethylmethacrylatehydrogels: Use for cell growth,2064 1049 Combinedglutamine and serumdeprivation: Effects on glucose control Filament of hexose transportin mammalianfibroblast cultures, 5958 see also Microfilament;Neurofilament Complementationof arylsulfataseA in somatichybrids of metachromatic High molecularweight polypeptides(270,000-340,000) from cultured leukodystrophyand multiplesulfatase deficiency disorder fibroblasts, cells are related to hog brain microtubule-associatedproteins but 6166 copurifywith intermediatefilaments, 4808 Corrugated attachment membrane in WI-38 fibroblasts: Alternating Intermediatefilaments from baby hamsterkidney (BHK-21) cells: In fibronectinfibers and actin-containingfocal contacts,4108 vitro assembly(correction), 1721 Cytoskeletalproteins vinculin and a-actinin:Altered distributions in Intermediatefilaments of baby hamsterkidney (BHK-21) cells and culturedfibroblasts transformed by Rous sarcomavirus, 6687 bovine epidermalkeratinocytes have similarultrastructures and Cytotypicallyspecific transfectingactivity of DNA from C57BL/Ka subunit domainstructures, 4534 mouse cells producingthymotropic in contrastto nonthymotropic Liver tumorsdistinguished by immunofluorescencemicroscopy with retroviruses, 6189 antibodiesto proteinsof intermediate-sizedfilaments, 4948 Defect in structureof type I procollagenin a patient who had Microtubulesand intermediatefilaments in chickengizzard cells: osteogenesis imperfecta: Excess mannose in COOH-terminal Associationas detected by double immunofluorescence,4769 propeptide,6179 Monoclonalantibodies against trophectoderm-specificmarkers during Error-freeexcision of cytotoxic,mutagenic N2-deoxyguanosine DNA mouse blastocystformation, 4113 adduct formedin humanfibroblasts by Phorbol 12-myristate13-acetate: Selective effects on myofibrilsand (-)-7/,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 10-nmfilaments, 5273 5933 Flagellarphase variation Fibronectinis not presentin focal adhesionsformed between normal Nucleotidesequence of an invertiblecontrolling element, 4196 culturedfibroblasts and their substrata,7318 Flagellum Glycosaminoglycansthat bind cold-insolubleglobulin in cell-substratum Similaritiesand dissimilaritiesbetween calmodulinand a adhesionsites of murinefibroblasts, 6662 Chlamydomonasflagellar protein, 4779 Humanlysosomes can be purifiedfrom diploid skin fibroblastsby Flavin reductase free-flowelectrophoresis, 6139 Physical interactionand activity couplingbetween two enzymes induced Immunosuppressivefactors: In vitro productionby murinesarcoma by immobilizationof one, 249 virus-transformedmouse fibroblasts,2205 Flavin semiquinone Inabilityof serumfrom abetalipoproteinemicsubjects to stimulate Flavin semiquinone:Presence in methanoloxidase, 7099 proliferationof humansmooth muscle cells and dermalfibroblasts in Flow cytometry vitro, 1511 HumanT lymphocytesand their subclasses:Simple and rapid Interferoninhibits conversionof 3T3-L1mouse fibroblastsinto measurementin peripheralblood, 4914 adipocytes,4099 Subcompartmentsof G1phase of cell cycle detected by flow cytometry, Interferon inhibits conversion of 3T3-L1 mouse fibroblasts into 6696 adipocytes(correction), 6941 Flunitrazepam Isolationof a Chinesehamster fibroblast mutant defective in hexose Benzodiazepinereceptor protein identified and visualizedin brain tissue transportand aerobicglycolysis: Its use to dissect the malignant by photoaffinitylabel, 1666 phenotype,2698 Diazepamreceptor: Specific nuclearbinding of [3H]flunitrazepam,1195 Le interferonmRNA from human fibroblasts,5341 Fluorescein Phorbolester tumorpromoters: Specific binding,567 Effect of bleachinglight on measurementsof lateral diffusion in cell Platelet-derivedgrowth factor stimulateslow density lipoprotein membranesby fluorescencephotobleaching recovery method, 2043 receptoractivity in culturedhuman fibroblasts, 5962 Fluoresceinisothiocyanate-phalloidin Protein synthetic errorsdo not increaseduring aging of culturedhuman CytoskeletalF-actin patterns quantitatedwith fluorescein fibroblasts,1885 isothiocyanate-phalloidinin normaland transformedcells, 6624 Receptor-mediateduptake of 3,3',5-triiodo-L-thyronineby cultured Fluorescence fibroblasts,3425 see also Immunofluorescence Regulationof insulin receptors:Evidence for involvementof an Acetylcholinereceptors on myotubes:Crosslinkage and visualizationwith endocytoticinternalization pathway, 5975 biotinylateda-bungarotoxin and fluorescentavidin, 4823 Regulationof stability of poly(I)-poly(C)-inducedhuman fibroblast Acetylcholinesterase:Photodestruction, 1980 interferonmRNA: Selective inactivationof interferonmRNA and lack 3-Adrenergicreceptor in frog erythrocytemembranes: Cytoskeletal of involvementof 2',5'-oligo(A)synthetase activation during shutoff of constraint,6401 interferonproduction, 3489 Cyanobacterialphycobilisomes: Selective dissociationmonitored by Sequentialaddition of platelet factor and plasmato BALB/c 3T3 fluorescenceand circulardichroism, 1961 fibroblastcultures stimulates somatomedin-C binding early in cell CytoskeletalF-actin patternsquantitated with fluorescein cycle, 6644 isothiocyanate-phalloidinin normaland transformedcells, 6624 Serumfactors modify cellularrequirement for Ca2+,K+, Mg2+, Fluorescenceenergy transfer studies on active site of papain,940 phosphateions, and 2-oxocarboxylicacids for multiplicationof normal Fluorescencestaining of actin cytoskeletonin living cells with humanfibroblasts, 3417 7-nitrobenz-2-oxa-1,3-diazole-phallacidin,980 Serumfactors modify cellularrequirement for Ca2+,K+, Mg2+, Fluorescencestaining of actin cytoskeletonin living cells with phosphateions, and 2-oxocarboxylicacids for multiplicationof normal 7-nitrobenz-2-oxa-l,3-diazole-phallacidin(correction), 3747 humanfibroblasts (correction), 6254 Lateraldistribution and diffusion of C3b receptorof complement,HLA Simian virus 40-transformed human fibroblasts: Reversible growth antigens,and lipid probesin peripheralblood leukocytes,6587 arrest, 7306 Mitochondria:Localization in living cells with rhodamine123, 990 Specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in Receptor-mediatedinternalization of fluorescentgonadotropin-releasing fibroblasts from patients with isovaleric acidemia, 580 hormoneby pituitarygonadotropes, 6692 Spreading of fibroblasts in medium containing cytochalasin B: Receptor-mediateduptake of 3,3',5-triiodo-L-thyronineby cultured Formation of lamellar cytoplasm as a combination of several fibroblasts,3425 functionally different processes, 5919 Fluorescence-activatedcell sorting Synthesis of new proteins associated with induction of interferon in Cell cycle and differentialexpression of HLA-A,Band HLA-DRantigens human fibroblast cells, 4918 on humanB lymphoidcells, 7297 Taxol stabilizes microtubules in mouse fibroblast cells, 1561 Receptor-mediatedendocytosis of antibody-opsonizedliposomes by Thermal stability of type I and type III procollagens from normal human tumor cells, 4089 fibroblasts and from a patient with osteogenesis imperfecta, 162 Variantsof mouse myelomaX63 that expresschanged immunoglobulin Thymidinekinase and humanglobin genes microinjectedinto mouse class:Isolation, 2909 fibroblasts:Replication and expression,5399 Fluorescenceimmunoassay Transformationof culturedC3H/1OT1/2 mouse embryofibroblasts by Fluorescenceimmunoassay based on long time correlationsof number 3-methylcholanthrene:Probabilistic view, 7272 fluctuations,4904 Transformationof rat embryofibroblasts by cloned polyomavirus DNA Fluorescencephotobleaching recovery fragmentscontaining only part of the early region,3978 Lateralmobility of band 3 in humanerythrocyte membrane studied by Two interferonmRNAs in humanfibroblasts: In vitro translationand fluorescencephotobleaching recovery: Control by cytoskeletal Escherichia coli cloning studies, 7152 interactions,2537 Vinculin,an intracellularprotein localizedat specializedsites where Fluorescencepolarization microfilamentbundles terminate at cell membranes,4127 Oligosaccharidemotion in erythrocytemembranes investigated by Fibronectin picosecondfluorescence polarization and microseconddichroism of an Corrugatedattachment membrane in WI-38fibroblasts: Alternating optical probe,5899 fibronectinfibers and actin-containingfocal contacts,4108 Fluoride Embryonalcarcinoma cell line F9:Growth and differentiationin defined Macromoleculewhich enhancesfluoride activation of adenylatecyclase: media,457 Partial purificationand characterization,4628 Fibronectin:Deposition during reverse transformation of Chinese hamsterovary cells by cyclic AMP, 985 Calcium-regulatedphosphorylation in synaptosomalcytosol: Dependence Fibronectin:Functional domain structure, 2661 on calmodulin,5812 Fibronectinis not present in focal adhesionsformed between normal Calmodulinactivation of plant microsomalCa2+ uptake, 7311 culturedfibroblasts and their substrata,7318 Follicle-stimulatinghormone Fibronectin:Synthesis and localizationduring collagenous see Follitropin matrix-mesenchymalcell interactionand differentiationof cartilage and bone in vivo, 2074 Downloaded by guest on September 29, 2021 7568 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Cellular genes: Activation by avian RNA tumor viruses, 5351 Gene, interferonsensitivity Cloning and complete nucleotide sequence of human 5'-a-globin gene, Genes coding for sensitivityto interferon(IfRec) and solublesuperoxide 7054 dismutase(SOD-I) are linked in mouse and man and map to mouse Cloning and direct examination of a structurally abnormal human chromosome16, 2168 30-thalassemia globin gene, 3558 Gene, intracisternalA-particle Closely linked adult chicken a-globin genes in recombinant DNAs, 2596 IntracisternalA-particle genes: Identification in genomeof Mus DNA sequences surrounding human y-, I-, and /-globin genes: Cloning musculusand comparisonof multiple isolates from a mouse gene and characterization, 4229 library,3571 Gene deletions in a thalassemia prove that the 5' v locus is functional, Gene, Ir 3586 MurineT cell Ia antigens:Specificity Iat.46 maps in I-J to I-E Globin domains: Heme binding to central exon product, 1384 chromosomalsegment of H-2 complex,6783 Globin domains: Heme binding to central exon product (correction), Gene,/-lactamase 3747 Segment-directedmutagenesis: Construction in vitro of point mutations a-Globin-like gene that has cleanly lost both globin intervening limited to a small predeterminedregion of a circularDNA molecule, sequences, 2806 5375 Limited DNase I nicking as a probe of gene conformation, 1907 Gene, lamB Linkage of genes for adult a-globin and embryonic a-like globin chains, Synthesis and maturationof Xreceptor in Escherichiacoli K-12:In vivo 1087 and in vitro expressionof gene lamB under lac promotercontrol, 1491 Prenatal diagnosis of sickle cell anemia by restriction endonuclease Gene,Lap analysis:HindIII polymorphismsin y-globingenes extend test Aminopeptidaseallele frequencydine maintainedby naturalselection, applicability, 2853 5385 Proportion of hemoglobin G Philadelphia (a268Asn'LyS~2) in Gene, lexA heterozygotes is determined by interaction with a-globin gene lexA gene productrepresses its own promoter,1932 deletions, 6874 Gene, lipoprotein Rapid duplication and loss of genes coding for a chains of hemoglobin, DNA sequenceof Serratia marcescenslipoprotein gene, 1369 2158 Gene, livK Silent b-globin gene in Old World monkeys, 3563 Amino-terminalsequence and processingof precursorof leucine-specific and human globin genes microinjected into mouse bindingprotein, and evidencefor conformationaldifferences between fibroblasts: Replication and expression, 5399 precursorand matureform, 2005 Tissue-specific DNA methylation in a cluster of rabbit /-like globin Gene loss genes, 6634 Rapid duplicationand loss of genes codingfor a chains of hemoglobin, Transcription in vitro of normal, mutant, and truncated mouse a- globin 2158 genes, 7132 Gene, malate dehydrogenase Triplicated a-globin loci in humans, 518 Duplicatedcytosolic malate dehydrogenasegenes in Zea mays, 4866 Unusual sequence homology at 5' ends of developmentally regulated /A, Gene, metallothionein fC-, and y-globingenes of the goat, 7127 Mouse metallothionein-Igene: Isolation and characterization,6511 Viral thymidine kinase gene and the human /-globin gene introduced Gene, nif into developmentally multipotential mouse teratocarcinoma cells, 2098 Broadhost rangeDNA cloningsystem for Gram-negativebacteria: Gene, heat-shock-inducedprotein Constructionof a gene bank of Rhizobiummeliloti, 7347 Genes for three Drosophila heat-shock-induced proteins at a single locus, CyanobacterialnifH gene coding for nitrogenasereductase: Nucleotide 2134 sequence,6476 Gene, histone Electrontransport to nitrogenasein Klebsiella pneumoniae,2555 Regulatorysequences in preludesequences of an H2A histone gene Gene, nitrogenfixation identifiedby study of specific deletion mutants in vivo, 1432 Blue-greenalgae nitrogenfixation gene:Identification by using SpacerDNA sequencesupstream of the T-A-T-A-A-A-T-Asequence are heterologousDNA hybridizationprobes, 186 essential for promotionof H2A histone gene transcriptionin vivo, 7102 Nitrogenasegenes: Interspecies homology, 191 Gene, hypoxanthinephosphoribosyltransferase Gene, nusA InactiveX chromosomeDNA does not function in DNA-mediatedcell L factorrequired for /-galactosidasesynthesis is the nusA gene product transformation for the hypoxanthine phosphoribosyltransferase gene, involvedin transcriptiontermination, 1991 4895 Gene, obesity Gene, I Acetonemetabolism in mice:Increased activity in mice heterozygousfor Interaction between I region loci influences expression of a cell surface Ia obesity genes, 290 antigen,5404 Gene, ompA Gene, immunoglobulin Regulatoryregion of gene for ompAprotein, a majorouter membrane Geneticcontrol of murineIgD structuralheterogeneity, 4256 proteinof Escherichiacoli, 3845 ImmunoglobulinV/J recombinationis accompaniedby deletion of Gene, ovalbumin joining site and variableregion segments, 6022 Correctsplicing of a chickenovalbumin gene transcriptin mouse L cells, Gene, immunoglobulinheavy chain 740 Cloningand partialnucleotide sequence of humanimmunoglobulin , Ovalbuminis synthesizedin mouse cells transformedwith natural chain cDNA from B cells and mouse-humanhybridomas, 6027 chickenovalbumin gene, 244 Evolutionaryapproach to questionof immunoglobulinheavy chain Transcriptionunits of chickenovalbumin genes observedafter injection switching:Evidence from cloned humanand mouse genes, 6734 of cloned completegenes into Xenopus oocyte nuclei, 5984 Exon shufflinggenerates an immunoglobulinheavy chain gene, 2138 Gene, prealbumin Genes for humanimmunoglobulin heavy chain variableregion: Structure Linkageanalyses of murineimmunoglobulin heavy chain and serum and multiplicity,6561 prealbumingenes establishtheir locationon chromosome12 proximal ImmunoglobulinC, gene:Expression in mouse T and B lymphoidand to the T(5;12)31Hbreakpoint in band 12F1, 550 myeloidcell lines, 2876 Gene, prolactin Immunoglobulinheavy chain genes:Rearrangement during Genomicorganization of rat prolactinand growthhormone genes, 4583 B-lymphocytedevelopment as revealedby studies of mouse Gene,RAD52 plasmacytoma cells, 1422 RAD52gene is requiredfor homothallicinterconversion of matingtypes Intervening sequences divide the gene for constant region of mouse and spontaneousmitotic recombinationin yeast, 503 immunoglobulin i chains into segments, each encoding a domain, 554 Gene, recA Linkageanalyses of murineimmunoglobulin heavy chain and serum recA gene of Escherichiacoli: Organization,313 prealbumingenes establish their location on chromosome12 proximal Sequencesof recA gene and protein,2611 to the T(5;12)31H breakpoint in band 12F1, 550 Gene regulation Nucleotide sequence divergence of mouse immunoglobulin yi and Y2b BacteriophageX vehicle for direct cloningof Escherichiacoli promoter chain genes and hypothesis of intervening sequence-mediated domain DNA sequences:Feedback regulation of rplJL-rpoBCoperon, 2124 transfer, 2143 Cell-freecoupled transcription-translation system for investigationof Nucleotide sequence of immunoglobulin heavy chain joining segments linear DNA segments,7029 between translocated VH and A constant region genes, 3630 DNA-dependenttranscription of adenovirusgenes in a soluble whole-cell Rearrangement of immunoglobulin -yl-chain gene and mechanism for extract,3855 heavy-chain class switch, 919 DNA-transformedmurine teratocarcinoma cells: Regulationof Somatic rearrangements forming active immunoglobulin , genes in B expressionof simian virus 40 tumor antigen in stem versus and T lymphoid cell lines, 4943 differentiatedcells, 4875 Transcription of mouse Kchain genes: Implications for allelic exclusion, Geneticregulation of catalasedevelopmental program in maize 1937 scutellum:Identification of a temporalregulatory gene, 5360 Transcripts of the immunoglobulin C, gene vary in structure and Metabolitegene regulationof L-arabinoseoperon in Escherichiacoli splicing during lymphoid development, 7400 with indoleaceticacid and other indole derivatives,1768 Gene, immunoglobulinlight chain Regulation of histidine operon of Salmonella: Model, 508 Organization of Klight chain genes in germ-line and somatic tissue, 1106 Unusual sequence homology at 5' ends of developmentally regulated -A, Gene, int PC-, and y-globin genes of the goat, 7127 DNA sequence of regulatory region for integration gene of bacteriophage Gene, restriction X, 2477 Akvr-1, a dominant murine leukemia virus restriction gene, is Site-specific recombination functions of bacteriophage X: DNA sequence polymorphic in leukemia-prone wild mice, 531 of regulatory regions and overlapping structural genes for Int and Xis, Gene, ribosomalnucleic acid 2482 Specific transcription factor that can bind either the 5S RNA gene or 5S RNA, 4170 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7569

Folitropin Gene, Ah Blockadeof recruitmentof ovarianfollicles by suppressionof secoQsdary Cultured mouse embryos metabolize benzo[a]pyrene during early surge of follicle-stimulating hormone with porcine follicular fluid,i'4953 gestatio6: Genetic differences detectable by sister chromatid exchange, 6-Formylpterin 3524 Pteridines as nonretinal regulators of light-dependent melatonin Gene amplification biosynthesis, 2415 Chromosome-mediated gene transfer results in two classes of unstable Free radical transformants, 3610 Free radical reduction enhanced by elevated concentrations of ascorbic Differential amplification of specific areas of phage T4 genome as acid in avian dystrophic muscle, 790 revealed by hybridization to cloned genetic segments, 5064 Organ chemiluminescence: Noninvasive assay for oxidative radical Transformation of mammalian cells with an amplifiable dominant-acting reactions, 347 gene, 3567 Fremyelladiplosiphon Untranslated mRNA for a chorion protein of Drosophila melanogaster Cyanobacterial phycobilisomes: Selective dissociation monitored by accumulates transiently at onset of specific gene amplification, 5789 fluorescence and circular dichroism, 1961 Gene, argininosuccinate synthetase Friend polycythemia virus complex Human argininosuccinate synthetase gene: Expression in hamster Helper virus is not required for in vitro erythroid transformation of transferents, 4234 hematopoietic cells by Friend virus, 5287 Gene, bacteriophage X repressor Friend virus Promoter for establishment of repressor synthesis in bacteriophage X, see Leukemia virus, Friend 3191 Frog Gene, casein see Rana catesbeiana;Rana pipiens Absolute requirement of glucocorticoid for expression of the casein gene Fructose-bisphosphatase (EC 3.1.3.11) in presence of prolactin, 6003 Formation of a rabbit liver aldolase-rabbit liver Gene, cbpA fructose-1,6-bisphosphatase complex, 3889 The cbpA gene: Role of the 26,000-dalton carbohydrate-binding protein Fructose-bisphosphate aldolase (EC 4.1.2.13) in intercellular cohesion of developing Dictyostelium discoideum cells, Formation of a rabbit liver aldolase-rabbit liver 4788 fructose-1,6-bisphosphatase complex, 3889 Gene, CDCIO Fungus Centromere-linked CDC10 gene: Isolation by complementation in yeast, see also specific fungi 2173 Cell wall appositions and plant disease resistance: Acoustic microscopy Isolation of genes by complementation in yeast: Molecular cloning of a of papillae that block fungal ingress, 2046 cell-cycle gene, 2119 Ecological and evolutionary significance of mycorrhizal symbioses in Gene, cheA vascular plants (A Review), 2113 Overlappinggenes at cheA locus of Escherichiacoli, 5370 Gene, chloramphenicolresistance (EC 2.7.1.6) Functional expression in yeast of Escherichia coli plasmid gene coding Cotransferof linked eukaryoticgenes and efficient transferof for chloramphenicol acetyltransferase, 1078 hypoxanthinephosphoribosyltransferase by DNA-mediatedgene Gene, collagen transfer,1583 Overlappinggenomic clones coveringchicken a2 (type I) collagengene: a-Galactosidase Isolationand characterization,7059 Comparative gene mapping: Order of loci on X chromosome is different Gene, complement in mice and humans,3595 Inherited structural polymorphism of the fourth component of human f-Galactosidase complement, 3576 Evolution of a new enzymatic function by recombination within a gene, Gene, 3529 Conalbumin gene: Specific in vitro transcription is drastically decreased L factorrequired for f-galactosidasesynthesis is the nusA gene product by single-point mutation in T-A-T-A box homology sequence, 7024 involved in transcription termination, 1991 Gene, b-crystallin f-Galactosidephosphate Comparison of two b-crystallin genes in chicken, 5879 /-Galactoside phosphate accumulation: Regulation in Streptococcus Gene, cytochrome c pyogenes by an expulsion mechanism, 5497 Gene for iso-2-cytochrome c in Saccharomyces cerevisiae: Isolation and Ganglion sequence, 541 see also Neuron Gene, developmentallyregulated Fast axonal transport in auditory neurons of guinea pig: A rapidly Cyclic AMP: A role in expression of developmentally regulated genes in turned-over glycoprotein, 3042 Dictyostelium discoideum, 1044 Graded synaptic transmission between spiking neurons, 3733 Gene duplication Nerve growth factor stimulates development of substance P in sensory Complete amino acid sequence of pooled papain-solubilized HLA-A, -B, ganglia, 649 and -C antigens: Relatedness to immunoglobulins and internal Peptidergic transmission in sympathetic ganglia, 5008 homologies, 1129 Ganglioside Duplicated cytosolic malate dehydrogenase genes in Zea mays, 4866 Mouse fibroblast (type I) and immune (type II) interferons: Pronounced Rapid duplication and loss of genes coding for a chains of hemoglobin, differences in affinity for gangliosides and in antiviral and antigrowth 2158 effects on mouse leukemia L-1210R cells, 2528 Gene, estrogen-dependent Sendai virus receptor: Proposed recognition structure based on binding Coordinate regulation of two estrogen-dependent genes in avian liver, to plastic-adsorbed gangliosides, 1947 4474 Gap junction Gene expression Independent lines of evidence suggesting a major gap junctional protein Cell cycle regulation of dihydrofolate reductase mRNA metabolism in with a molecular weight of 26,000, 970 mouse fibroblasts, 5140 Gastric acid Cloning of active thymidine kinase gene of herpes simplex virus type 1 in Brain regulation of gastric secretion: Influence of neuropeptides, 5515 Escherichia coli K-12 (correction), 4390 Gastrin Constitutive uncoupling of pathways of gene expression that control Immunohistochemical localization of cholecystokinin- and gastrin-like growth and differentiation in myeloid leukemia: Model for origin and peptides in brain and hypophysis of rat, 1190 progression of malignancy, 6152 Gene Deoxyribonuclease I-sensitive structure reconstituted on active genes, see also Operon; Ribonucleic acid, messenger 1787 Gene, acid phosphatase-1 Gene expression: Control by a mobile recombinational switch, 4880 Autosomal dominant aniridia: Probable linkage to acid phosphatase-1 Genetic regulation of catalase developmental program in maize locus on chromosome 2, 1580 scutellum: Identification of a temporal regulatory gene, 5360 Gene, actin Posttranscriptional modification of mRNA conformation: Mechanism Actin gene sequences in sea urchin: Molecular cloning of an that regulates erythromycin-induced resistance, 7079 intron-containing DNA sequence coding for a cytoplasmic actin, 5683 Protein synthesis: Regulation during spore germination in Dictyostelium Cloning of sea urchin actin gene sequences for use in studying regulation discoideum, 1791 of actin gene transcription, 765 Regulation of early adenovirus transcription: A protein product of early Gene for actin in Saccharomyces cerevisiae: Isolation and sequence, 3912 region 2 specifically represses region 4 transcription, 1893 Putative actin genes in macronucleus of Oxytricha fallax, 5336 Viral thymidine kinase gene and the human /-globin gene introduced Structure of a split yeast gene: Complete nucleotide sequence of actin into developmentally multipotential mouse teratocarcinoma cells, 2098 gene in Saccharomyces cerevisiae, 2546 Gene, Fv-1 Gene, cis-active regulatory Cytotypically specific transfecting activity of DNA from C57BL/Ka cis-Active in regulatory gene mouse: Direct demonstration of cis-active mouse cells producing thymotropic in contrast to nonthymotropic control of rate of enzyme subunit synthesis, 4193 retroviruses, 6189 Gene, acycloguanosine resistance Synthesis and circularization of N- and B-tropic retroviral DNA in Fv-1 Resistance of herpes simplex virus to acycloguanosine: Role of viral permissive and restrictive mouse cells, 2994 thymidine kinase and DNA polymerase loci, 2270 Gene, germline Two distinct loci confer resistance to acycloguanosine in herpes simplex Hybridoma proteins expressing the predominant idiotype of the virus type 1, 2265 antiazophenylarsonate response of A/J mice, 1120 Gene, Adh Gene, glnA Drosophila alcohol dehydrogenase gene: Isolation and partial Expression from glnA promoter of Escherichia coli: Regulation in characterization, 5794 absence of glutamine synthetase, 7372 Gene, globin Activation of human /-globin genes from nonerythroid cells by fusion with murine erythroleukemia cells, 3435 Downloaded by guest on September 29, 2021 7570 BiologicalSciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Gene, ribosomalprotein Isolationof diploidhuman lymphoblast mutants presumably Feedbackregulation of ribosomalprotein gene expressionin Escherichia homozygous for ouabain resistance, 1101 coli, 3590 Phenotypic evolution of cells resistant to bromodeoxyuridine, 4206 Feedbackregulation of ribosomalprotein gene expressionin Escherichia Somatic cell genetic analysis of regulation of expression of coli: Structuralhomology of ribosomalRNA and ribosomalprotein 3-hydroxy-3-methylglutaryl coenzyme A reductase, 6621 mRNA, 7084 Somatic cell genetics of adenosine deaminase expression and severe Gene, ribosomalribonucleic acid combined immunodeficiency disease in humans, 4211 Completenucleotide sequence of 23S ribosomalRNA gene from Variants of mouse myeloma X63 that express changed immunoglobulin Escherichiacoli, 201 class: Isolation, 2909 Genetic exchangesamong ribosomal genes on nonhomologous Genetic transmission chromosomesin man and apes: Molecularevidence, 7323 Inheritance of acquired immunological tolerance to foreign RibosomalRNA genes in human-mousehybrid cells: Reactivationby histocompatibilty antigens in mice, 2871 12-0-tetradecanoylphorbol13-acetate, 1566 Inheritance of acquired immunological tolerance to foreign Yeast ribosomalRNA genes:Replication and meiotic transmission,6739 histocompatibility antigens in mice (correction), 4390 Gene,sarc Genetic variation Relationshipof polypeptideproducts of the transforminggene of Rous Genetic variability and effective population size when local extinction sarcomavirus and the homologousgene of vertebrates,2059 and recolonization of subpopulations are frequent, 6710 Gene, Sgs-4 Increased mutation in crosses between geographically separated strains Molecularanalysis of a gene in a developmentallyregulated puff of of Drosophilamelanogaster, 1059 Drosophilamelanogaster, 7362 Quantitative genetic variation of enzyme activities in natural populations Molecularlimits on size of a genetic locus in Drosophilamelanogaster, of Drosophila melanogaster, 1073 7367 Rare structuralvariants of humanand murineuroporphyrinogen I Gene, somatotropin synthase, 2848 Genomicorganization of rat prolactinand growthhormone genes, 4583 Self-fertilization and monogenic strains in natural populations of Gene,src terrestrial slugs, 684 Adhesionplaques of Rous sarcomavirus-transformed cells containthe Gene transfer src gene product,3514 Chromosome-mediated gene transfer results in two classes of unstable Associationof the src gene productof Rous sarcomavirus with transformants, 3610 cytoskeletalstructures of chickenembryo fibroblasts, 3484 Cotransfer of linked eukaryotic genes and efficient transfer of Homologyexists amongtransforming sequences of avian and feline hypoxanthine phosphoribosyltransferase by DNA-mediated gene sarcomaviruses, 6536 transfer, 1583 Relationshipof polypeptideproducts of the transforminggene of Rous Direct transferof cloned genes from bacteriato mammaliancells, 2163 sarcomavirus and the homologousgene of vertebrates,2059 Genetic manipulation by means of microcell-mediated transfer of normal Transforminggene of Fujinamisarcoma virus: Characterization, 3009 human chromosomes into recipient mouse cells, 5394 Transforminggene productof Rous sarcomavirus phosphorylates Genetic transformation of mouse embryos by microinjection of purified tyrosine,1311 DNA, 7380 Gene, superoxidedismutase Hepatitis B surface antigen particles excreted from mouse cells Genes codingfor sensitivity to interferon(IfRec) and soluble superoxide transformed with cloned viral DNA, 4549 dismutase(SOD-1) are linked in mouse and man and map to mouse Human argininosuccinate synthetase gene: Expression in hamster chromosome16, 2168 transferents, 4234 Gene, talpid Methylation of foreign DNA sequences in eukaryotic cells, 6463 talpid2mutant of the chickenwith perturbedcartilage development has Nucleosomal packaging of thymidine kinase gene of herpes simplex virus an altered precartilage-specificchromatin protein, 4828 transferred into mouse cells: Actively expressed single-copy gene, 5079 Gene, thrA Thymidine kinase and human globin genes microinjected into mouse Nucleotidesequence of thrA gene of Escherichiacoli, 5730 fibroblasts: Replication and expression, 5399 Gene, thymidinekinase Transformation of mammalian cells with an amplifiable dominant-acting Chromosome-mediatedgene transferresults in two classes of unstable gene, 3567 transformants,3610 Gene, transfer ribonucleic acid Cloningof active thymidinekinase gene of herpessimplex virus type 1 in Composite tRNA gene constructed by anticodon loop transplant, 5092 Escherichiacoli K-12 (correction),4390 Reiteration frequency mapping: Analysis of repetitive sequence DNA-transformedmurine teratocarcinoma cells: Regulationof organization within cloned DNA fragments containing human initiator expressionof simian virus 40 tumor antigen in stem versus methionine tRNA gene, 5668 differentiatedcells, 4875 Transcription of tRNA genes in vivo: Single-stranded compared to Nucleosomalpackaging of thymidinekinase gene of herpessimplex virus double-strandedtemplates, 4147 transferredinto mouse cells: Actively expressedsingle-copy gene, 5079 Two control regions for eukaryotic tRNA gene transcription, 3365 Thymidinekinase and humanglobin genes microinjectedinto mouse Yeast tRNA gene containing a modified intervening sequence: fibroblasts:Replication and expression,5399 Transcriptionand processing,2564 Viral thymidinekinase gene and the human 3-globingene introduced Gene, trpR into developmentallymultipotential mouse teratocarcinomacells, 2098 Nucleotide sequence and expression of Escherichia coli trpR, structural Geneticcode gene for trp aporepressor, 7117 Codonrecognition rules in yeast mitochondria,3167 Gene, unc Differentpattern of codon recognitionby mammalianmitochondrial Organization of unc gene cluster of Escherichia coli coding for tRNAs, 3164 proton-translocating ATPase of oxidative phosphorylation, 7005 Genetic code and codon readingpatterns in Neurosporacrassa Gene, xis mitochondria:Novel featuresbased on sequencesof six mitochondrial DNA sequence of regulatory region for integration gene of bacteriophage tRNAs, 3159 X,2477 Minimizationof chemicaldistances between amino acids:Role in Site-specific recombination functions of bacteriophage X: DNA sequence evolutionof the genetic code, 1083 of regulatoryregions and overlappingstructural genes for Int and Xis, tRNA evolution:Convergence and minimalmutation criteria for 2482 evaluatingearly events, 2791 Geryonquinquedens Geneticengineering Selective amplification of variants of a complex repeating unit in DNA of Manufactureof diploid/tetraploidchimeric mice, 6012 a crustacean,2786 Genetic recombination Gillichthysmirabilis see Recombination,genetic Urotensin II: A somatostatin-like peptide in the caudal neurosecretory Genetics,human radiation system of fishes, 5021 Searchfor mutationsaffecting protein structure in childrenof atomic Glaucoma bomb survivors:Preliminary report, 4221 Adrenergic regulation of intraocular pressure: Identification of Genetics,population /2-adrenergic-stimulated adenylate cyclase in ciliary process Averagetime until fixation of a mutant allele in a finite population epithelium, 7420 undercontinued mutation pressure: Studies by analytical,numerical, Glioma-conditionedmedium and pseudo-samplingmethods, 522 Sensory neurons in culture: Changing requirements for survival factors Diffusionmodel for genotype-dependentmigration, 4842 during embryonic development, 1199 Geneticvariability and effective populationsize when local extinction Globin and recolonizationof subpopulationsare frequent,6710 see also Gene, globin; Ribonucleic acid, messenger, globin Polymorphismin mitochondrialDNA of humansas revealedby Globin chain synthesis in single erythroid bursts from cord blood: y - f3 restrictionendonuclease analysis, 3605 and Gy -. Ay switches, 362 Quantitativegenetic variationof enzymeactivities in naturalpopulations Globulin,cold-insoluble of Drosophila melanogaster, 1073 Glycosaminoglycans that bind cold-insoluble globulin in cell-substratum Selection limits and strategies, 546 adhesion sites of murine fibroblasts, 6662 Genetics,somatic cell Glucagon Chromosome-mediated gene transfer results in two classes of unstable Distal nephron of rat kidney: A target site for glucagon, 3422 transformants, 3610 Fetal rat liver cell line established that retains differentiated liver Cotransfer of linked eukaryotic genes and efficient transfer of functions, 2731 hypoxanthine phosphoribosyltransferase by DNA-mediated gene Glucagon: Mechanism of action on hepatocyte phosphofructokinase transfer, 1583 activity, 6501 Geneticmanipulation by means of microcell-mediatedtransfer of normal Glucagon-related peptides in rat brain: Identification and localization, human chromosomesinto recipientmouse cells, 5394 6229 Humanargininosuccinate synthetase gene: Expressionin hamster Increased ATP inhibition of liver phosphofructokinase from genetically transferents, 4234 diabetic mice, 2497 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7571

Glucocorticoid Isolationof a Chinesehamster fibroblast mutant defective in hexose see also Receptor,glucocorticoid transport and aerobic : Its use to dissect the malignant Absoluterequirement of glucocorticoidfor expressionof the casein gene phenotype,2698 in presenceof prolactin,6003 Permeabilizationof animal cells for kinetic studies of intracellular Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: enzymes: In situ behavior of glycolytic enzymes of erythrocytes, 6324 Action on protein phosphatase(s)and its inhibitor(s),5711 Glucocorticoidhormones increase activity of plasmamembrane alkaline Membrane differentiation in human erythroid cells: Unique profiles of phosphodiesteraseI in rat hepatomacells, 1005 cell surface glycoproteins expressed in erythroblasts in vitro from PhospholipaseA2 inhibitoryprotein in rabbit neutrophilsinduced by three ontogenicstages, 3474 glucocorticoids,2533 Positive cooperativity in a (dissected) lectin-membrane glycoprotein Gluconeogenesis binding event, 3788 Acetonemetabolism in mice:Increased activity in mice heterozygousfor Glycoprotem obesity genes, 290 see also Receptor, Glyoxylatecycle in toad urinarybladder: Possible stimulationby Cellular adhesion: Role of a 16S glycoprotein complex, 4137 aldosterone,1521 Coated vesicles transport newly synthesized D-Glucosamine from endoplasmicreticulum to plasma membranein two successive Membrane-activedrugs potentiate killing of tumor cells by stages, 780 D-glucosamine,1172 Differenthalf-lives of carbohydrateand protein moieties of a 3-O-SulfatedD-glucosamine residue in antithrombin-bindingsequence of 110,000-dalton glycoprotein isolated from plasma membranes of rat heparin,6551 liver, 1828 Glucose Differentiationof human and murinemyeloid leukemia cells inducedin see also Deoxyglucose;Transport, glucose culture by tunicamycin, 409 Combinedglutamine and serum deprivation:Effects on glucose control Dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase: of hexose transportin mammalianfibroblast cultures, 5958 Solubilization, purification, and properties, 3811 Insulinrelease, insulin sensitivity, and glucoseintolerance, 7425 Fast axonal transport in auditory neurons of guinea pig: A rapidly Plasminogenactivator of islets of Langerhans:Modulation by glucose turned-over glycoprotein, 3042 and correlationwith insulin production,875 Gix antigenexpression: Relationship to glycosylationof murineleukemia Glucose6-phosphate virus glycoprotein, 6420 Insulin and glucose6-phosphate stimulation of Ca2+uptake by skinned Glycosylation patterns of closely related murine leukemia viruses: musclefibers, 936 Differences,67 Glucose-6-phosphatedehydrogenase (EC 1.1.1.49) High molecular weight antigens present on human T cells, 6805 Localizationof loci for hypoxanthinephosphoribosyltransferase and Humanprotein related to majorenvelope protein of murinemammary glucose-6-phosphatedehydrogenase and biochemicalevidence of tumorvirus: Identification and characterization,1301 nonrandomX chromosomeexpression from studies of a human Humans have antibodies capable of recognizing oncoviral glycoproteins: X-autosome translocation,2810 Demonstration that these antibodies are formed in response to cellular Glucose-l-phosphateuridylyltransferase (EC 2.7.7.9) modificationof glycoproteinsrather than as consequenceof exposure Renaturation and localization of enzymes in polyacrylamide gels: Studies to virus, 1617 with UDPglucosepyrophosphorylase of Dictyostelium,730 Immunoselectionof mutants deficient in cell surfaceglycoproteins Glutamicacid encodedby murineerythroleukemia viruses,' 57 L-Glutamicacid as a mediatorof sexual morphogenesisin Volvox Interferon-treated cells release vesicular stomatitis virus particles lacking capensis, 1025 glycoprotein spikes: Correlation with biochemical data, 2284 Pyrroline-5-carboxylatesynthase activity in mammaliancells, 5221 Isolation of BPgp70, a fibroblast receptor for the envelope antigen of Regulationof hippocampalglutamate receptors: Involvement of a Rauscher murine leukemia virus, 4988 calcium-activatedprotease, 2298 Macular corneal dystrophy: Failure to synthesize a mature keratan Glutamine sulfate proteoglycan, 3705 Combinedglutamine and serum deprivation:Effects on glucosecontrol Malignancies of metastatic murine lymphosarcoma cell lines and clones of hexose transportin mammalianfibroblast cultures, 5958 correlate with decreased cell surface display of RNA tumor virus Glutaminesynthetase (EC 6.3.1.2) envelopeglycoprotein gp70, 5943 Anti-AMPantibody precipitation of multiplyadenylylated forms of Mannose: Transfer from GDP-mannose to lipid-linked glutaminesynthetase from Escherichiacoli: Model relatingboth by soluble mannosyl , 2524 concentrationand density of antigenicsites with antibody-antigen Molecular dissection of Rauscher virus gp70 by using monoclonal interaction,7410 antibodies: Localization of acquired sequences of related envelope gene Expressionfrom glnA promoterof Escherichiacoli: Regulationin recombinants, 4524 absenceof glutaminesynthetase, 7372 Monoclonalantibodies against major glycoprotein (gp350/220) of Rhizobiumnitrogen fixation: Regulation by unadenylylatedglutamine Epstein-Barr virus neutralize infectivity, 5307 synthetaseI system, 5817 Monoclonal antibody against a 250,000-dalton glycoprotein of Synthesis of glutaminesynthetase regulated by PII protein in Klebsiella Epstein-Barr virus identifies a membrane antigen and a neutralizing aerogenes,2636 antigen, 2979 Glutaminyl-peptidey-glutamyltransferase (EC 2.3.2.13) Nucleotide sequences associated with differences in electrophoretic Transglutaminase:Participation in receptor-mediatedendocytosis, 2706 mobility of envelope glycoprotein gp70 and with Gix antigen 'y-Glutamylaminecyclotransferase phenotype of certain murine leukemia viruses, 1642 y-Glutamylaminecyclotransferase: Specificity toward Oligosaccharide moieties of glycoprotein hormones: Bovine lutropin E-(L-y-glutamyl)-L-lysineand related compounds,4564 resists enzymatic deglycosylation because of terminal O-sulfated '-Glutamylcysteine N-acetylhexosamines, 7089 Cysteineand y-glutamylcysteinemoieties: Excretion in humanand Specificity of human antibodies to oncovirus glycoproteins: Recognition experimentalanimal y-glutamyltranspeptidase deficiency, 3384 of antigen by natural antibodies directed against carbohydrate y-Glutamyltransferase(EC 2.3.2.2) structures, 1622 LeukotrieneD: Slow reactingsubstance from rat basophilicleukemia Trypanosoma brucei brucei: Inhibition of glycosylation of major variable cells, 2014 surface coat glycoprotein by tunicamycin, 1529 'y-Glutamyltranspeptidase Vesicular stomatitis virus glycoprotein: Transport in a cell-free extract, Cysteineand y-glutamylcysteinemoieties: Excretion in humanand 3870 experimental animal y-glutamyl transpeptidase deficiency, 3384 Vesicular stomatitis virus glycoprotein is anchored in viral membrane by Glutaryl-CoAdehydrogenase (EC 1.3.99.7) a hydrophobic domain near the COOH terminus, 3884 Isovaleryl-CoAdehydrogenase: Demonstration in rat liver mitochondria Glycosaminoglycan by ion-exchange chromatography and isoelectric focusing, 2646 Experimental animal model for mucopolysaccharidosis: Suramin-induced Glutathione glycosaminoglycan and sphingolipid accumulation in rats, 3700 Cysteine and -y-glutamylcysteine moieties: Excretion in human and Glycosaminoglycans that bind cold-insoluble globulin in cell-substratum experimental animal y-glutamyl transpeptidase deficiency, 3384 adhesion sites of murine fibroblasts, 6662 Glutathione transport by inside-outvesicles from human erythrocytes, Glycoside 6359 see also Cardiac glycoside Relationship of biosynthesis of slow reacting substance to intracellular Fecalase: A model for activation of dietary glycosides to mutagens by glutathione concentrations, 6870 intestinal flora, 4961 Glyceraldehyde-phosphate dehydrogenase (EC 1.2.1.12) Glycosylation Mechanism of negative cooperativity in glyceraldehyde-3-phosphate Carbohydrate requirement for expression and stability of acetylcholine dehydrogenase deduced from ligand competition experiments, 5055 receptor on surface of embryonic muscle cells in culture, 5263 Permeabilization of animal cells for kinetic studies of intracellular Glycosylation patterns of closely related murine leukemia viruses: enzymes: In situ behavior of glycolytic enzymes of erythrocytes, 6324 Differences, 67 Rate enhancement of reconstitution of glyceraldehyde-3-phosphate High molecularweight antigenspresent on human T cells, 6805 dehydrogenase by a covalently bound coenzyme analog, 1966 Trypanosoma brucei brucei: Inhibition of glycosylation of major variable Glycine max surface coat glycoprotein by tunicamycin, 1529 Auxin-inducedchanges in patternsof proteinsynthesis in soybean GlyoxalaseI hypocotyl,357 Gammaray-induced loss of expressionof HLA and glyoxalaseI alleles in Glycogen lymphoblastoidcells, 4251 Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: Glyoxylatecycle Action on protein phosphatase(s) and its inhibitor(s), 5711 Glyoxylatecycle in toad urinarybladder: Possible stimulationby Glycolipid,synthetic aldosterone,1521 Synthetic glycolipids: Functional incorporation into cells, 2510 Golgi apparatus Glycolysis Insulin causes translocation of glucose transport activity to plasma Activation factor of liver phosphofructokinase, 5861 membrane from an intracellular storage site, 2542 Downloaded by guest on September 29, 2021 7572 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Vesicular stomatitis virus glycoprotein: Transport in a cell-free extract, Serum stimulation of phospholipase A2 and prostaglandin release in 3T3 3870 cells is associated with platelet-derived growth-promoting activity, 137 Gonadoliberin Growth factor, sarcoma Direct inhibition of testicular function by gonadotropin-releasing Transforming growth factors: Isolation of polypeptides from virally and hormone: Mediation by specific gonadotropin-releasing hormone chemically transformed cells by acid/ethanol extraction, 3494 receptors in interstitial cells, 4459 Growth factor, serum Receptor-mediated internalization of fluorescent gonadotropin-releasing Inability of serum from abetalipoproteinemic subjects to stimulate hormone by pituitary gonadotropes, 6692 proliferation of human smooth muscle cells and dermal fibroblasts in Gonadotropin-releasing hormone vitro, 1511 see Gonadoliberin Serum factors modify cellular requirement for Ca2+, K+, Mg2+, Gramicidin phosphate ions, and 2-oxocarboxylic acids for multiplication of normal Lipid phase transition in planar bilayer membrane and its effect on human fibroblasts, 3417 carrier- and pore-mediated ion transport, 3403 Serum factors modify cellular requirement for Ca2+, K+, Mg2+, Rate theory calculation of gramicidin single-channel currents using phosphate ions, and 2-oxocarboxylic acids for multiplication of normal NMR-derived rate constants, 2028 human fibroblasts (correction), 6254 Granulocyte Growth factor, T-cell Poly(ADP-ribose) synthesis, a marker of granulocyte differentiation, Allospecific long-term human cytolytic T-cell lines: Development and 3682 characterization, 5432 Subpopulations of human peripheral granulocytes and monocytes Human T-cell growth factor from phytohemagglutinin-stimulated express receptors for IgA, 3640 lymphocyte-conditioned media: Purification and some characteristics, Granulocyte-macrophage colony-stimulating factor 6134 Action of granulocyte-macrophage colony-stimulating factors: Studies T-cell lines established from human T-lymphocytic neoplasias by direct using a human leukemia cell line, 5346 response to T-cell growth factor, 6815 Clonal analysis of proliferation and differentiation of paired daughter Type C retrovirus particles: Detection and isolation from fresh and cells:.Action of granulocyte-macrophage colony-stimulating factor on cultured lymphocytes of a patient with cutaneous T-cell lymphoma, granulocyte-macrophage precursors, 5327 7415 Grasshopper Growth factor, transforming Electrical excitability: Spectrum of properties in progeny of a single Transforming growth factors produced by certain human tumor cells: embryonic neuroblast, 1676' Polypeptides that interact with epidermal growth factor receptors, Electrical excitability: Spectrum of properties in progeny of a single 5258 embryonic neuroblast (correction), 4390 Growth hormone Growth factor see Somatotropin see also Cell growth Guanine nucleotide Chondrocytes contain a growth factor that is localized in nucleus and is /f-Adrenergic receptors and guanine nucleotide sites: Interaction in associated with chromatin, 2762 turkey erythrocyte membranes, 3801 Human platelet basic protein associated with antiheparin and mitogenic Naturally soluble component(s) that confer(s) guanine nucleotide and activities: Purification and partial characterization, 5914 fluoride sensitivity to adenylate cyclase, 3836 Multiplication-stimulating activity, an insulin-like growth factor: Guanine nucleotide regulatory protein Increased levels in fetal rat serum, 3649 Agonist-promoted coupling of /-adrenergic receptor with guanine Sertoli cells contain a mitogenic polypeptide, 4774 nucleotide regulatory protein of the adenylate cyclase system, 775 Growth factor,' epidermal Guanosine; acyclo- see also Epidermal growth factor-urogastrone; Receptor, epidermal 'Resistance of herpes simplex virus to acycloguanosine: Role of viral growth factor thymidine kinase and DNA polymerase loci, 2270 Colchicine inhibits epidermal growth factor degradation in 3T3 cells, 480 Two distinct loci confer resistance to acycloguanosine in herpes simplex Degradation process: Role in mitogenic effect of epidermal growth factor, virus type 1, 2265 1466 Guanosine 3',5'-cyclic monophosphate Epidermal growth factor and expression of specific genes: Effects on Calcium channels: Involvement in short-term desensitization of cultured rat pituitary cells are dissociable from mitogenic response, muscarinic receptor-mediated cyclic GMP formation in mouse 394 neuroblastoma cells, 6897 Epidermal growth factor-induced down-regulation of receptor does not Cyclic GMP-dependent protein kinase and substrate: Localization in occur in HeLa cells grown in defined medium, 2735 mammalian cerebellum, 5537 Genetic analysis of epidermal growth factor action: Assignment of Cyclic GMP: Involvement in intracellular signaling in chemotactic human epidermal growth factor receptor gene to chromosome 7, 4188 response of Escherichia coli, 3879 Genetics of cell surface receptors for bioactive polypeptides: Binding of Phospholipid methylation during chemotaxis in Dictyostelium epidermal growth factor is associated with the presence of human discoideum: Regulation by guanosine 3',5'-cyclic monophosphate, 6996 chromosome 7 in human-mouse cell hybrids, 3600 Products of reaction catalyzed by purified rat liver guanylate cyclase Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from determined by 31p NMR spectroscopy, 5734' them incorporate 32P into ribosomal protein S6, 2641 Guanosine 3'-diphosphate 5'-diphosphate Lysomotropic amines cause intracellular accumulation of receptors for Formylmethionyl-tRNA alters RNA polymerase specificity, 870 epidermal growth factor, 3283 RNA polymerase activity: Inhibition by Escherichia coli protein Mammalian epidermal growth factor promotes plant growth, 4836 biosynthesis elongation factor Ts, 866 Membrane permeability: Control by external and internal ATP in 3T6 Guanosine, 2'-O-methyl- cells grown in serum-free medium, 2103 Thermally induced biosynthesis of 2'-O-methylguanosine in tRNA from Mitogenic hormone-induced intracellular message: Assay and partial an extreme thermophile, Thermus thermophilus HB27, 1922 characterization of activator of DNA replication induced by epidermal Guanosinetriphosphatase growth factor, 112 Additional component required for activity and reconstitution of Growth factor, fibroblast light-activated vertebrate photoreceptor GTPase, 1408 Do plasma and serum have different abilities to promote cell growth? Photolyzed rhodopsin catalyzes exchange of GTP for bound GDP in 2726 retinal rod outer segments, 2500 Permissive effect of extracellular matrix on cell proliferation in vitro, Guanosine 5'-triphosphate 4094 Hydrolysis of GTP on elongation factor Tu-ribosome complexes Growth factor, nerve promoted'by 2'(3')-O-L-phenylalanyladenosine, 905 see also Receptor, nerve growth factor Photolyzed rhodopsin catalyzes exchange of GTP for bound GDP in Altered nerve growth factor in fibroblasts from patients with familial retinal rod outer segments, 2500 dysautonomia, 1154 Q/ replicase template specificity: Different templates require different Intracellular distribution of nerve growth factor in rat GTP concentrations for initiation, 2601 pheochromocytoma PC12 cells: Evidence for a perinuclear and Guanylate cyclase (EC 4.6.1.2) intranuclear location, 1656 Products of reaction catalyzed by purified rat liver guanylate cyclase Nerve growth factor: Acceleration of rate of wound healing in mice, 4379 determined by 31p NMR-spectroscopy, 5734 Nerve growth factor: Mobility, clustering, and transport in embryonal Guanyl nucleotide sensory cells and in a sympathetic neuronal cell line, 3469 Hormone-induced guanyl nucleotide binding and activation of adenylate Nerve growth factor stimulates development of substance P in sensory cyclase in Leydig cell, 5837 ganglia, 649. Guinea pig Ornithine decarboxylase: Induction by renin-free nerve growth factor, Fast axonal transport in auditory neurons of guinea pig: A rapidly 4607 turned-over glycoprotein, 3042 Rat pheochromocytoma cells (PC12) chemically fused and grown in culture: Physiological and morphological studies, 1701 Hair follicle Sensory neurons in culture: Changing requirements for survival factors Magnetic fields produced by steady currents in the body, 1447 during embryonic development, 1199 Halobacterium halobium Growth factor, platelet-derived Bacteriorhodopsin is an inside-out protein, 5894 Growth of normal human glial cells in a defined medium containing Delipidation of bacteriorhodopsin and reconstitution with exogenous platelet-derived growth factor, 6611 phospholipid, 323 Platelet-derived growth factor stimulates activity of low density Delipidation of bacteriorhodopsin and reconstitution with exogenous lipoprotein receptors, 4084 phopholipid (correction), 2353 Platelet-derived growth factor stimulates low density lipoprotein Exchange kinetics of Schiff base proton in bacteriorhodopsin, 6571 receptor activity in cultured human fibroblasts, 5962 Halobacteria: Anaerobic growth, 3821 Sequential addition of platelet factor and plasma to BALB/c 3T3 Orthorhombic two-dimensional crystal form of purple membrane, 338 fibroblast cultures stimulates somatomedin-C binding early in cell Hansenula polymorpha cycle, 6644 Flavin semiquinone: Presence in oxidase, 7099 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7573

Hansenula wingei Glucagon: Mechanism of action on hepatocyte phosphofructokinase Cell-cell recognitionin yeast: Purificationof Hansenula wingei 21-cell activity, 6501 sexual agglutinationfactor and comparisonof factorsfrom three Metabolism of native and of lactosylated human low density lipoprotein: genera,318 Evidence for two pathways for catabolism of exogenous proteins in rat Haptoglobin hepatocytes, 5923 Covalentstructure of humanhaptoglobin: A serine proteasehomolog, Regulation of insulin binding to isolated hepatocytes: Correction for 3388 bound hormone fragments linearizes Scatchard plots, 3176 Haptoglobinheavy chain:Model based upon structuralhomology, 3393 Serum protein production in hepatocyte hybridomas: Immortalization Heart and expression of normal hepatocyte genes, 6616 see also Cell, heart;Myocardial infarction Hepatoma Independenceof positive inotropiceffect of ouabainfrom inhibitionof Colchicine-sensitive uptake system in Morris hepatomas, 5282 the heart Na+/K+ pump, 3067 Herpes simplexvirus Rat heart analyzedin vivo by phosphorusnuclear magnetic resonance, Cloning of active thymidine kinase gene of herpes simplex virus type 1 in 299 -Escherichia coli K-12 (correction), 4390 Hematopoiesis Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences Cellularand molecularbasis of increasedsplenic hemopoiesisin mice as BamHI fragments, 4201 treated with bacterialcell wall components,4322 Deoxyribopyrimidine triphosphatase activity specific for cells infected Differentiationof humanpromyelocytic leukemia cell line (HL-60): with herpes simplex virus type 1, 1872 Inductionby retinoicacid, 2936 Nucleosomal packaging of thymidine kinase gene of herpes simplex virus Humanbone marrowcells: Long-termculture, 4756 transferred into mouse cells: Actively expressed single-copy gene, 5079 Structuredvariation in self-renewalcapacity within long-termbone Regulation of herpesvirus macromolecular synthesis: marrowcultures, 2927 Transcription-initiation sites and domains of a genes, 7122 Heme Resistance of herpes simplex virus to acycloguanosine: Role of viral Bindingof 02 and CO to hemes and hemoproteins,3171 thymidine kinase and DNA polyrerase loci, 2270 Hemocyanin,carbon monoxide Tumorigenic transformation induced by specific fragment of DNA from Carbonmonoxide hemocyanins: Luminescence, 2387 herpes simplex virus type 2, 2279 Hemoglobin Two distinct loci confer resistance to acycloguanosine in herpes simplex Binding of 02 and CO to hemes and hemoproteins,3171 virus type 1, 2265 Globinchain synthesis in single erythroidbursts from cord blood:y -- / Viral DNA sequences in hamster cells transformed by herpes simplex and Gy - Ak switches, 362 virus type 2, 880 Interactionbetween cytochrome b5 and hemoglobin:Involvement of f66 Herpesvirus (E10) and 395 (FG2) lysyl residuesof hemoglobin,1917 Origin of replication of DNA of a herpesvirus (pseudorabies), 172 Interactionof oxy- and deoxyhemoglobinswith erythrocytemembrane: Heterochromatin Kinetic study 7147 Asynchronous replication of heterochromatin in maize, 6705 Linkage of aG-Philadelphia to a-thalassemia in African-Americans, 4885 Proportion of hemoglobin G Philadelphia (a268Asn-Lys/2) in Enzymic catalysis and energy coupling: Relationship, 5703 heterozygotesis determinedby interactionwith a-globin gene Hexokinase(EC 2.7.1.1) deletions, 6874 Permeabilization of animal cells for kinetic studies of intracellular Rapid duplicationand loss of genes coding for a chains of hemoglobin, enzymes: In situ behavior of glycolytic enzymes of erythrocytes, 6324 2158 Hexosamine Hemoglobin,carbon monoxide Regulation of hexosamine biosynthetic pathway in water mold Magneticmoment of carbonmonoxide hemoglobin from carp: Blastocladiella emersonii: Sensitivity to endproduct inhibition is Variability,1462 dependent upon life cycle phase, 5998 Hemoglobin,deoxy- Hexose monophosphateshunt DeoxyhemoglobinS polymer:Determination in sickle erythrocytesupon Plasminogen activator secretion in macrophages induced by deoxygenation,5487 electrochemical stimulation of hexose monophosphate shunt with Differencesin Fe(II)-N,(His-F8)stretching frequencies between methylene blue, 414 deoxyhemoglobinsin the two alternativequaternary structures, 2033 Hippocampus Proton longitudinalrelaxation investigation of histidyl residuesof Preferential neurotoxicity of colchicine for granule cells of dentate gyrus normalhuman adult and sickle deoxyhemoglobin:Existence of of adult rat, 3047 pregelationaggregates in sickle deoxyhemoglobinsolutions, 6577 Repeated seizures induce long-term increase in hippocampal Hemoglobin,fetal' benzodiazepine receptors, 3029 Proportionof fetal hemoglobinsynthesis decreasesduring erythroid cell Hiranobody maturation,2757 Crystalline ribosomes are present in brains from senile humans, 2260 HemoglobinH Histamine Linkageof genes for adult a-globin and embryonica-like globin chains, Phospholipid methylation, Ca2+ influx, and histamine release: 1087 Stimulation by bridging of IgE receptors on rat mast cells, 1903 Histone DeoxyhemoglobinS polymer:Determination in sickle erythrocytesupon see also Gene, histone; Protein, histone-like; Ribonucleic acid, messenger, deoxygenation,5487 histone Effect of cetiedil on erythrocytesickling: New type of antisicklingagent Aggregation of small oligonucleosomal chains into 300-A globular that may affect erythrocytemembranes, 2955 particles,6443 HemoglobinS: Solubilizationby other hemoglobins,5130 Isolation of newly replicated chromatin by using shallow metrizamide Kinetics of fiber-to-crystaltransition of sickle cell hemoglobin:Electron gradients, 3336 microscopestudy, 944 Meiotic synthesis of testis histones in rats, 371 Ligand-linkedphase changesin a biologicalsystem: Applications to Points of contact between histone H1 and histone octamer, 127 sickle cell hemoglobin,5239 Quantitationof mRNAs duringmouse spermatogenesis:Protamine-like Proton longitudinalrelaxation investigation of histidyl residuesof histone and -2 mRNAs increase after meiosis, normalhuman adult and sickle deoxyhemoglobin:Existence of 6086" pregelationaggregates in sickle deoxyhemoglobinsolutions, 6577 Reversibledissociation of linkerhistone from chromatinwith Sickle-cellhemoglobin: Fall in osmotic pressure'upondeoxygenation, preservation of internucleosomal repeat, 885 4310 Structurally unique basic protein-coextracted with histones from calf Heparansulfate thymus chromatin, 1389 Heparansulfate-containing proteoglycan isolated from basement Histrionicotoxin membrane,4494 see also Perhydrohistrionicotoxin Sanfilippodisease type D: Deficiencyof N-acetylglucosamine-6-sulfate Substance P enhances cholinergic receptor desensitization in a clonal sulfataserequired for heparansulfate degradation,6822 nerve cell line, 634 Heparin Holocentrusascensionis 3-O-SulfatedD-glucosamine residue in antithrombin-bindingsequence of Microtubules of cells: Visualization in situ by indirect heparin,6551 immunofluorescence, 6657 Hepatitis B virus Homocysteine see'also Antigen,hepatitis B Simian virus 40-transformedhuman fibroblasts: Reversible growth Chronichepatitis in chimpanzeecarriers of hepatitis B virus: arrest, 7306 Morphologic,immunologic, and viral DNA studies, 6147 Homoserine dehydrogenase (EC 1.1.1.3) Clonedhepatitis B virus DNA: Expressionin humancell cultures,5507 Nucleotide sequence of thrA gene of Escherichia coli, 5730 Hepatitis B surfaceantigen particlesexcreted from mouse cells Sequential folding of a bifunctional allosteric protein, 3379 transformedwith cloned viral DNA, 4549 Hordeumvulgare Recombinant DNAs derived from genomes of human hepatitis B virus Cell wall appositionsand plant disease resistance:Acoustic microscopy and woodchuck hepatitis virus: Isolation, characterization, and of papillaethat block fungal ingress,2046 comparison, 1842 Hormone Virus in Beechey ground squirrels that is related to hepatitis B virus of see also specific hormones humans,2941 Calcium-dependent hormonal regulation of amino acid transport and Hepatocyte cyclic AMP accumulation in rat hepatocyte monolayer cultures, 5953 Calcium-dependenthormonal regulation of amino acid transportand Hormonal control of human colon carcinoma cell growth in serum-free cyclic AMP accumulationin rat hepatocytemonolayer cultures, 5953 medium, 3464 Cell surfacemolecule involved in aggregationof embryonicliver cells, Hormone-dependent functional epithelial cells from rat thyroids: '4831 - ' Culture,3455 CytOskeletonof digitonin-treatedrat hepatocytes,3430 Inhibiting the onset of hormone-induced desensitization of viable thymocytes by Nj-tosyl-L-lysine chloromethyl ketone, 5967 Downloaded by guest on September 29, 2021 7574 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Hybridcell Hydroxymethylglutaryl-CoAreductase (EC 1.1.1.88) Chromatinrepeat length in somatichybrids, 2716 Somaticcell genetic analysisof regulationof expressionof Complementationof arylsulfataseA in somatic hybridsof metachromatic 3-hydroxy-3-methylglutarylcoenzyme A reductase,6621 leukodystrophyand multiplesulfatase deficiency disorder fibroblasts, Hydroxymethylglutaryl-CoAreductase (NADPH) (EC 1.1.1.34) 6166 Isopentenyladenine as a mediator of mevalonate-regulated DNA Human-humanhybridomas producing monoclonal antibodies of replication, 5842 predefinedantigenic'specificity, 5429 Mevinolin: A highly potent competitive inhibitor of Immunoglobulinchain loss in hybridomalines, 2197 hydroxymethylglutaryl-coenzyme A reductase and a Monoclonalantibodies specific for carcinoembryonicantigen and cholesterol-lowering agent, 3957 producedby two hybridcell lines, 563 Regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase Serumprotein production in hepatocytehybridomas: Immortalization in vivo: Enzyme phosphorylation as an early regulatory response after and expressionof normalhepatocyte genes, 6616 intragastric administration of mevalonolactone, 6429 Hybridcell, hamster-mouse Hydroxyproline Comparativegene mapping:Order of loci on X chromosomeis different Regulation of production of secretory proteins: Intracellular degradation in mice and humans,3595 of newly synthesized "defective" collagen, 4746 Simultaneousexpression of mouse immunoglobulinsM and D is Hyperapobetalipoproteinemia determinedby the same homologof chromosome12, 6793 see also Abetalipoproteinemia Hybridcell, human-mouse Coronary atherosclerosis associated with hyperapobetalipoproteinemia Cloningand partialnucleotide sequence of humanimmunoglobulin i [increased protein but normal cholesterol levels in human plasma low chain cDNA from B cells and mouse-humanhybridomas, 6027 density (3) lipoproteins], 604 Expressionof an X-linked gene from an inactivehuman X chromosome Hypertension in mouse-humanhybrid cells: Noninactivationof the Abnormal net Na+ and K+ fluxes in erythrocytes of three varieties of locus in man, 6759 genetically hypertensive rats, 4283 Generationof humanmonoclonal antibodies reactive with human Specific inhibition of renin by an angiotensinogen analog: Sodium mammarycarcinoma cells, 6841 depletion and renin-dependent hypertension, 5476 Geneticanalysis of epidermalgrowth factor action: Assignment of Hypophysectomy humanepidermal growth factor receptor gene to chromosome7, 4188 f-Endorphin: Stability, clearance behavior, and entry into the central Geneticsof cell surfacereceptors for bioactivepolypeptides: Binding of nervous system after intravenous injection of the tritiated peptide in epidermalgrowth factor is associatedwith the presenceof human rats and rabbits, 4588 chromosome7 in human-mousecell hybrids,3600 Hypophysis RibosomalRNA genes in human-mousehybrid cells: Reactivationby Immunohistochemical localization of cholecystokinin- and gastrin-like 12-O-tetradecanoylphorbol13-acetate, 1566 peptides in brain and hypophysis of rat, 1190 Uniparentalpropagation of mitochondrialDNA in mouse-humancell hybrids,4079 Hypotensive action of parathyroid hormone preparations on rats and Hybridcell, neuroblastoma-glioma dogs, 675 Solubilizationof active opiate receptors,4623 Hypothalamus Hybridcell, rabbit-mouse Biosynthesis of precursor corticotropin/endorphin-, corticotropin-, Rabbit-mousehybridomas secreting rabbit immunoglobulin chains: a-melanotropin-, f-lipotropin-, andd/-endorphin-like material by Identificationand characterization,2899 cultured, neonatal rat hypothalamic neurons, 1880 Hybridization,nucleic acid Development of circadian rhythmicity and light responsiveness in the rat AlbuminmRNA absent in liver of analbuminemicrats, 3215 suprachiasmatic nucleus: A study using the 2-deoxy[1-14C]glucose Blue-greenalgae nitrogenfixation gene: Identificationby using method, 1204 heterologousDNA hybridizationprobes, 186 Isolation and structure of pro-somatostatin: A putative somatostatin Cell cycle regulationof dihydrofolatereductase mRNA metabolismin precursor from pig hypothalamus, 4489 mouse fibroblasts,5140 Morphine and opioid peptides reduce paraventricular neuronal activity: Cloningand analysisof a cDNA coding for bovine prothrombin,5153 Studies on rat hypothalamic slice preparation, 5527 Developmentalshifts in frequencydistribution of polysomalmRNA and Ontogenetic patterns of thyrotropin-releasing hormone-like material in their posttranscriptionalregulation in sea urchinembryo, 4653 rat hypothalamus, pancreas, and retina: Selective effect of light Formationof a RNA primerfor initiation of replicationof ColEl DNA deprivation, 4345 by ribonucleaseH, 2450 Ovine hypothalamic somatostatin-28 and somatostatin-25: Primary Gene-directedmutagenesis in bacteriophageT7 providedby structure, 6827 polyalkylatingRNAs complementaryto selected DNA sites, 2796 Presumptive common precursor for neuronal and glial cell lineages in Geneticstructure of avian myeloblastosisvirus, released from mouse hypothalamus, 4165 transformedmyeloblasts as a defective virus particle,5120 Presumptive common precursor for neuronal and glial cell lineages in Hybridizationof denaturedRNA and small DNA fragmentstransferred mouse hypothalamus (correction), 6941 to nitrocellulose,5201 ,f-[Tyr9]Melanotropin-(9-18) decapeptide from pig hypothalami: Nitrogenasegenes: Interspecies homology, 191 Isolation, structure, biological characterization, and synthesis, 3947 Nucleic acid spot hybridization:Rapid quantitativescreening of Hypoxanthinephosphoribosyltransferase lymphoidcell lines for Epstein-Barrviral DNA, 6851 see also Gene, hypoxanthine phosphoribosyltransferase OKIO an avian acute leukemiavirus of the MC29subgroup with a Cell cycle-specific mutagenesis at hypoxanthine unique genetic structure,7142 phosphoribosyltransferase locus in adult rat liver epithelial cells, 7377 Processingof precursorsof 21S ribosomalRNA from yeast mitochondria, Comparative gene mapping: Order of loci on X chromosome is different 1417 in mice and humans, 3595 Proteins encodedby Agrobacteriumtumefaciens Ti plasmidDNA Hypoxanthinephosphoribosyltransferase (EC 2.4.2.8) (T-DNA) in crowngall tumors,2666 Cotransfer of linked eukaryotic genes and efficient transfer of RNA encodedby eukaryotictransposable element copia: Translation hypoxanthine phosphoribosyltransferase by DNA-mediated gene and developmentalregulation, 7107 transfer, 1583 RNA from the rplJL-rpoBCtranscription unit of Escherichiacoli: Genetics of cell surface receptors for bioactive polypeptides: Binding of Attenuationand processing,3331 epidermal growth factor is associated with the presence of human RNA in D loops of intracellularX DNA, 2153 chromosome 7 in human-mouse cell hybrids, 3600 Hybridoma Localization of loci for hypoxanthine phosphoribosyltransferase and see Hybridcell glucose-6-phosphate dehydrogenase and biochemical evidence of Hydrocortisone nonrandom X chromosome expression from studies of a human (2'-5')01igo(A)polymerase activity: Elevated levels in human X-autosome translocation, 2810 lymphoblastoidcells treated with glucocorticoids,6506 Hypoxia Hydrogenexchange Cell bioenergetics: Noninvasive, nondestructive approaches, 7430 Open state in long polynucleotidedouble helices:Possibility of soliton excitations,7222 Immunity,cell-mediated Hydrogenperoxide T-T hybridoma product specifically suppresses tumor immunity, 2866 Monocyte-mediatedcytotoxicity: Oxidative mechanisms, 584 Immunofluorescence Hydroperoxide see also Fluorescence Organchemiluminescence: Noninvasive assay for oxidativeradical Adhesion plaques of Rous sarcoma virus-transformed cells contain the reactions,347 src gene product, 3514 12L-Hydroperoxy-5,8,10,14-icosatetraenoicacid Aggregation of luteinizing hormone receptors in granulosa cells: Possible Arachidonatemetabolism via lipoxygenaseand mechanism of desensitization to the hormone, 3440 12L-hydroperoxy-5,8,10,14-icosatetraenoicacid peroxidasesensitive to Appearance of cytoskeletal components on the surface of leukemia cells anti-inflammatorydrugs, 308 and of lymphocytes transformed by mitogens and Epstein-Barr virus, Hydroxybenzylpindolol 4979 /-Adrenergic receptors: Induction and properties during erythroid Brain clathrin: Immunofluorescent patterns in cultured cells and tissues, differentiation of Friend leukemic cells, 4065 5520 Hydroxyindole-O-methyltransferase Calmodulin localization in mammalian spermatozoa, 2772 see Acetylserotonin methyltransferase Cloned hepatitis B virus DNA: Expression in human cell cultures, 5507 Hydroxylamine Ecdysterone localized on polytene chromosomes of Drosophila Complement proteins: Covalent binding and hemolytic activity, 7194 melanogaster, 2108 a-Hydroxyleucine Germinal mutation detection in vivo with monospecific antibody against Preprotein processing: Inhibition in ascites tumor lysates by lactate dehydrogenase-X, 7352 incorporation of a leucine analog, 1356 Immunoreactive helix-destabilizing protein localized in transcriptionally active regions of Drosophila polytene chromosomes, 6749 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7575

Intracellulardistribution of nerve growthfactor in rat Regulation of cyclic AMP formation in brain tissue by a-adrenergic pheochromocytoma PC12 cells: Evidence for a perinuclear and receptors: Requisite intermediacy of prostaglandins of the E series, intranuclear location, 1656 3024 Liver tumors distinguished by immunofluorescence microscopy with Inflammation antibodies to proteins of intermediate-sized filaments, 4948 Free radicals and inflammation: Superoxide-dependent activation of a Microtubules and intermediate filaments in chicken gizzard cells: neutrophilchemotactic factor in plasma, 1159 Association as detected by double immunofluorescence, 4769 Phospholipase A2 inhibitory protein in rabbit neutrophils induced by Microtubules of cells: Visualization in situ by indirect glucocorticoids, 2533 immunofluorescence, 6657 Influenzavirus Phorbol 12-myristate 13-acetate: Selective effects on myofibrils and Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA 10-nmfilaments, 5273 strongly influence its ability to act as primer for influenza virus RNA Poly(ADP-ribose)synthesis, a markerof granulocytedifferentiation, transcription,3952 3682 Cloning DNA sequences from influenza viral RNA segments, 210 Two tumor antigensand their polypeptidesin adenovirustype Influenza defective interfering viral RNA is formed by internal deletion 12-infectedand transformedcells, 2274 of genomic RNA, 215 Immunoglobulin Mapping of two overlapping genes for polypeptides NS1 and NS2 on see also Antibody; Receptor, immunoglobulin RNA segment 8 of influenza virus genome, 1857 Adenylate cyclase and immunologic release of mediators from rat mast Nucleotide sequence of influenza virus RNA segment 8 indicates that cells: Agonist and antagonist effects of purine- and ribose-modified coding regions for NS1 and NS2 proteins overlap, 5074 adenosineanalogs, 6800 Priming and inhibitory activities of RNAs for influenza viral Electronmicrographs of negativelystained protein molecules:Fidelity of transcriptase do not require base pairing with virion template RNA, structure representation, 4721 5874 Fluorescence immunoassay based on long time correlations of number Initiationfactor, eukaryotic fluctuations,4904 Double-stranded RNA-activated eukaryotic initiation factor 2 kinase Geneticcontrol of murineIgD structuralheterogeneity, 4256 from rabbit reticulocytes: Purification and properties, 6526 IgM antibodies induce production of antibodies of the same specificity, Double-stranded-RNA-activated kinase that phosphorylates a subunit of 1125 eukaryotic initiation factor 2 (eIF-2a) in reticulocyte lysates, 832 Immunoglobulin chain loss in hybridoma lines, 2197 Purification of a factor that restores translation of vesicular stomatitis Monoclonal antibody that defines an immunoregulatory T cell subset for virus mRNA in extracts from poliovirus-infected HeLa cells, 770 immunoglobulin synthesis in humans: Characterization, 2914 Rabbit reticulocyte initiation factor 2 contains two polypeptide chains of Rabbit-mouse hybridomas secreting rabbit immunoglobulin chains: molecular weights 48,000 and 38,000, 3356 Identification and characterization, 2899 Site-specific phosphorylation of a subunit of eukaryotic initiation factor Receptor-mediated transcellular transport of immunoglobulin: Synthesis eIF-2 by heme-regulated and double-stranded RNA-activated eIF-2a of secretory component as multiple and larger transmembrane forms, kinases from rabbit reticulocyte lysates, 1286 7257 Insertionelement Simultaneous expression of mouse immunoglobulins M and D is Donor insertion sequence IS1: Fate during transposition, 2514 determined by the same homolog of chromosome 12, 6793 Plasmids containing insertion elements are potential transposons, 750 Successive switching of antibody isotypes expressed within the lines of a Recombination genes on Escherichia coli sex factor specific for B-cell clone, 5424 transposable elements, 2814 Immunoglobulinheavy chain Insulin see also Gene, immunoglobulinheavy chain see also Receptor, insulin Aminoacid sequenceof variableregion of a human s chain:Location of Activation of pyruvate dehydrogenase by direct addition of insulin to an a possible JH segment, 3239 isolated plasma membrane/mitochondria mixture: Generation of Mouse immunoglobulina chain (MOPC511): Complete amino acid insulin's second messenger in a subcellular system, 77 sequence,4909 Continuous, clonal, insulin- and somatostatin-secreting cell lines Mouse immunoglobulinD: Constructionand characterizationof a cloned established from a transplantable rat islet cell tumor, 3519 6 chain cDNA, 7405 Coordinate modulation of D-glucose transport activity and bilayer Nucleotidesequence of immunoglobulinheavy chainjoining segments fluidity in plasma membranes derived from control and insulin-treated between translocated VH and ,t constant region genes, 3630 adipocytes, 915 Surfacecomponent of primatethymus-derived lymphocytes related to a Eukaryotic signal sequence transports insulin antigen in Escherichia heavy chain variableregion, 3625 coli, 3369 Variantsof mouse myelomaX63 that expresschanged immunoglobulin Evolutionary origins of vertebrate hormones: Substances similar to class:Isolation, 2909 mammalian insulins are native to unicellular eukaryotes, 6184 Immunoglobulinlight chain Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned see also Gene, immunoglobulin light chain muscle fibers, 936 Kchain joining segments and structuraldiversity of antibodycombining Insulin and serum increase number of receptors for vasopressin in a sites, 4270 kidney-derived line of cells grown in a defined medium, 5979 Interchain disulfide bond: Effect on hapten binding properties of light Insulin causes translocation of glucose transport activity to plasma chain dimer of protein 315 (correction), 1229 membrane from an intracellular storage site, 2542 Self-association of human immunoglobulin KIlight chains: Role of the Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of third hypervariable region, 1144 streptozotocin: Obligatory role of cell-mediated autoimmune processes, 6129 Immunohistochemical localization of cholecystokinin- and gastrin-like Insulin is ubiquitous in extrapancreatic tissues of rats and humans, 572 peptides in brain and hypophysis of rat, 1190 Insulin release, insulin sensitivity, and glucose intolerance, 7425 Immunoperoxidase Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from Immunoreactive renin: Wide distribution in nerve cells of human brain, them incorporate 32p into ribosomal protein S6, 2641 5458 Membrane permeability: Control by external and internal ATP in 3T6 Mouse mammary tumor virus: In vitro infectivity assay (correction), 689 cells grown in serum-free medium, 2103 Ouabain-resistant hyperpolarization induced by insulin in aggregates of Immunochemical determination of configuration of a haptenic embryonic heart cells, 3062 substituent, 4244 Plasminogen activator of islets of Langerhans: Modulation by glucose Molecular dissection of Rauscher virus gp70 by using monoclonal and correlation with insulin production, 875 antibodies: Localization of acquired sequences of related envelope gene Regulation of insulin binding to isolated hepatocytes: Correction for recombinants, 4524 bound hormone fragments linearizes Scatchard plots, 3176 Plasma membrane polypeptides of resident and activated mouse Semisynthesis and biological activity of porcine [LeuB24]insulin and peritoneal macrophages, 2188 [LeuB25]insulin,3181 Immunosuppressivefactor Serum protein production in hepatocyte hybridomas: Immortalization Immunosuppressive factors: In vitro production by murine sarcoma and expression of normal hepatocyte genes, 6616 virus-transformedmouse fibroblasts,2205 Interferencemicroscopy Switchingon the macrophage-mediatedsuppressor mechanism by tumor Classification of cultured mammalian cells by shape analysis and pattern cells to evade host immunesurveillance, 4265 recognition, 1516 Immunotherapy Interferon Anti-Thy 1.2 monoclonalantibody linked to ricin is a potent (2'-5')Oligo(A) polymerase activity: Elevated levels in human cell-type-specifictoxin, 5483 lymphoblastoidcells treated with glucocorticoids,6506 Passive immunotherapyprevents expression of endogenousMoloney Abnormalbehavior of interferon-inducedenzymatic activities in an virus and amplificationof proviralDNA in BALB/Mo mice, 3677 interferon-resistantcell line, 4479 Selective killing of normalor neoplasticB cells by antibodiescoupled to Amino-terminal amino acid sequence of human leukocyte interferon, A chain of ricin, 5419 5102 Incest Bacterialplasmids containing nucleotide sequence for humanleukocyte Gene-culturetranslation in avoidanceof sibling incest, 6248 interferon:Construction and identification,7010 Indoleaceticacid Double-strandedRNA inhibits a phosphoproteinphosphatase present in Metabolitegene regulationof L-arabinoseoperon in Escherichiacoli interferon-treatedcells, 107 with indoleaceticacid and other indole derivatives,1768 Establishmentof interferon-mediatedantiviral state: Role of fatty acid Indomethacin cyclooxygenase,5437 Arachidonatemetabolism via lipoxygenaseand Genes codingfor sensitivity to interferon(IfRec) and soluble superoxide 12L-hydroperoxy-5,8,10,14-icosatetraenoicacid peroxidasesensitive to dismutase(SOD-i) are linked in mouse and man and map to mouse anti-inflammatorydrugs, 308 chromosome16, 2168 Go-G1arrest: Role in inhibitionof tumor cell growthby interferon,1471 Humanfibroblast interferon gene: Expressionin Escherichiacoli, 5230 Downloaded by guest on September 29, 2021 7576 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Human fibroblast interferon: NH2-terminal amino acid sequence, 5716 Ischemia Human interferon: Spontaneous production, 5938 Autoradiographic method for measuring ischemic myocardium at risk: Human leukocyte interferon: Structural and biological relatedness to Effects of verapamil on infarct size after experimental coronary artery adrenocorticotropic hormone and endorphins, 5972 occlusion, 6119 Human type I and type II interferons: Differential efficacies as antiviral Prolonged derangements of canine myocardial purine metabolism after a and antiproliferative agents, 5928 brief coronary artery occlusion not associated with anatomic evidence Interferon inhibits conversion of 3T3-L1 mouse fibroblasts into of necrosis, 5471 adipocytes, 4099 Protection of cultured renal tubular epithelial cells from anoxic cell Interferon inhibits conversion of 3T3-L1 mouse fibroblasts into swelling and cell death, 5445 adipocytes (correction), 6941 Ising model Interferon-treated cells release vesicular stomatitis virus particles lacking Cooperative equilibrium binding of myosin subfragment 1 to glycoprotein spikes: Correlation with biochemical data, 2284 actin-troponin-tropomyosin complex: Theoretical model, 3186 Kinetics of decay in expression of interferon-dependent mRNAs Islets of Langerhans responsible for resistance to virus, 452 Biosynthesis in vitro of fish islet preprosomatostatin: Processing and Le interferon mRNA from human fibroblasts, 5341 segregation of a high molecular weight precursor, 4074 Mechanism of interferon action: Simian virus 40-specific early Continuous, clonal, insulin- and somatostatin-secreting cell lines polypeptides synthesized in untreated and interferon-treated monkey established from a transplantable rat islet cell tumor, 3519 kidney cells, 2419 Ontogenetic patterns of thyrotropin-releasing hormone-like material in Molecular cloning of human interferon cDNA, 4003 rat hypothalamus, pancreas, and retina: Selective effect of light Mouse fibroblast (type I) and immune (type II) interferons: Pronounced deprivation, 4345 differences in affinity for gangliosides and in antiviral and antigrowth Plasminogen activator of islets of Langerhans: Modulation by glucose effects on mouse leukemia L-1210R cells, 2528 and correlation with insulin production, 875 Regulation of stability of poly(I)-poly(C)-induced human fibroblast Prosomatostatin: Identification in pancreatic islets, 2410 interferon mRNA: Selective inactivation of interferon mRNA and lack Isocitratelyase (EC 4.1.3.1) of involvement of 2',5'-oligo(A) synthetase activation during shutoff of Glyoxylate cycle in toad urinary bladder: Possible stimulation by inteiferon production, 3489 aldosterone, 1521 Synthesis of new proteins associated with induction of interferon in Isoelectricfocusing human fibroblast cells, 4918 Isovaleryl-CoA dehydrogenase: Demonstration in rat liver mitochondria Target selectivity of interferon-induced human killer lymphocytes by ion-exchange chromatography and isoelectric focusing, 2646 related to their Fc receptor expression, 3620 Isoenzyme Intestinal mucosa see Isozyme Guinea pig intestinal electrolyte secretion: Control by a 6-opiate receptor, 2753 Multivalent translational control of transcription termination at Intracisternal type A particles attenuator of ilvGEDA operon of Escherichia coli K-12, 1862 Intracisternal A-particle genes: Identification in genome of Mus Nucleotide sequence of ilvGEDA operon attenuator region of musculus and comparison of multiple isolates from a mouse gene Escherichia coli, 1823 library, 3571 Isoproterenol Ion channel Desensitization of enucleated cells to hormones and role of cytoskeleton Activation, inactivation, and desensitization of acetylcholine receptor in control of normal hormonal response, 4798 channel complex detected by binding of perhydrohistrionicotoxin, 2309 Photoaffinity label for /-adrenergic receptor: Synthesis and effects on Anion channel blockers inhibit lysosomal enzyme secretion from human isoproterenol-stimulated adenylate cyclase, 4449 neutrophils without affecting generation of superoxide anion, 2721 Isoproterenol,hydroxybenzyl- Binding of sea anemone toxin to receptor sites associated with gating Agonist-promoted coupling of /-adrenergic receptor with guanine system of sodium channel in synaptic nerve endings in vitro, 1646 nucleotide regulatory protein of the adenylate cyclase system, 775 Calcium channels: Involvement in short-term desensitization of Isovaleric acidemia muscarinic receptor-mediated cyclic GMP formation in mouse Specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in neuroblastoma cells, 6897 fibroblasts from patients with isovaleric acidemia, 580 Catalytic subunit of cyclic AMP-dependent protein kinase: Isovaleryl-CoAdehydrogenase (EC 1.3.99.10) Microinjection enhances calcium action potentials of bag cell neurons Isovaleryl-CoA dehydrogenase: Demonstration in rat liver mitochondria in cell culture, 7487 by ion-exchange chromatography and isoelectric focusing, 2646 Functional acetylcholine receptor from Torpedo marmorata in planar Specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in membranes, 3052 fibroblasts from patients with isovaleric acidemia, 580 [3H]Phencyclidine: Probe for ionic channel of nicotinic receptor, 7458 Isozyme Kinetic models suggest bimolecular reaction steps in axonal Na+-channel see also Polymorphism gating, 6582 Active center of D- and L-lactate dehydrogenases: Studies using Ouabain-resistant hyperpolarization induced by insulin in aggregates of oxamate-diaminohexyl-Sepharose affinity chromatography, 5832 embryonic heart cells, 3062 A "mute" catalytic subunit of cyclic AMP-dependent protein kinase Reconstitution of purified acetylcholine receptors with functional ion from rat muscle and its mode of activation, 2492 channels in planar lipid bilayers, 3057 Isozymes of human phosphofructokinase: Identification and subunit Saxitoxin-binding component of excitable membrane sodium channel: structural characterization of a new system, 62 Purification from rat sarcolemma, 1306 New molecular forms of human liver alcohol dehydrogenase: Isolation Ionophore and characterization of ADHIndianapolis,5784 General method, employing arsenazo III in liposomes, for study of Rare structural variants of human and murine uroporphyrinogen I calcium ionophores: Results with A23187 and prostaglandins, 1506 synthase, 2848 Irradiation, atomic bomb Search for mutations affecting protein structure in children of atomic Junctional complex bomb survivors: Preliminary report, 4221 Phalloidin-induced cholestasis: Microfilament-mediated change in Irradiation, gamma ray junctional complex permeability, 2229 Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in Juvenile hormone lymphoblastoid cells, 4251 Juvenile hormone-binding protein from the cytosol of Drosophila Kc In vitro y irradiation of leukemic cells in mice, rats, and guinea pigs, cells, 4657 7435 Neuroendocrine regulation of corpus allatum activity in Manduca sexta: Irradiation, ultraviolet Sequential neurohormonal and nervous inhibition in the last-instar Acetylcholinesterase: Photodestruction, 1980 larva, 4407 Chemical carcinogen-modified DNA recognized by a DNA-binding protein, 3201 Kairomone Chemical carcinogen-modified DNA recognized by a DNA-binding Cucurbitacins as kairomones for diabroticite beetles, 3769 protein (correction), 7510 Kallikrein (EC 3.4.21.8) Electron microscope study of duck globin mRNA precursor crosslinked Membrane-bound kallikrein and renin in the kidney: Activation, 4975 in situ, 4683 Kanamycin Immunologic effects of whole-body ultraviolet irradiation: Selective Kanamycin resistance transposon Tn903: Genetic and DNA sequence defect in splenic adherent cell function in vitro, 2881 analysis, 7176 Naphthoquinones restore active transport of solutes and oxidative Keratansulfate proteoglycan phosphorylation in irradiated membrane vesicles from Mycobacterium Macular corneal dystrophy: Failure to synthesize a mature keratan phlei, 102 sulfate proteoglycan, 3705 Synthesis of a posterior indicator protein in normal embryos and double Keratin abdomens of Smittia sp. (Chironomidae, Diptera), 6700 Liver tumors distinguished by immunofluorescence microscopy with Irradiation,x- antibodies to proteins of intermediate-sized filaments, 4948 Effect of uncouplers on radiosensitivity and mutagenicity in x-irradiated Keratinocyte,bovine epidermal mammalian cells, 2702 Intermediate filaments of baby hamster kidney (BHK-21) cells and Ionizing radiation: Differential effects on circadian oscillator and other bovine epidermal keratinocytes have similar ultrastructures and functions in eye of Aplysia, 5542 subunit domain structures, 4534 Radiosensitivity in ataxia-telangiectasia: A new explanation, 7315 /-Ketoadipate pathway Relationship between x-ray exposure and malignant transformation in Origins of metabolic diversity: Substitution of homologous sequences C3H 1OT1/2 cells, 7262 into genes for enzymes with different catalytic activities, 5365 Relationships among chromatid interchanges, sister chromatid Ketocyclazocine exchanges, and meiotic recombination in Drosophila melanogaster, Multiple opiate receptors: [3H]Ethylketocyclazocine receptor binding 1575 and ketocyclazocine analgesia, 3691 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7577

Kidney Lentropin: A factor in vitreous humor which promotes lens fiber cell see also Cell, kidney; Cell, kidney epithelial; Renal tubule :differentiation, 490 Cellular and subcellular localization of 1,25-(OH)2-vitamin D3 in rat Majorlens membraneprotein: Synthesis in vitro, 725 kidney: Comparison with localization of parathyroid hormone and Lentropin estradiol, 1149 Lentropin:A factor in vitreoushumor which promoteslens fiber cell Deoxycorticosterone biosynthesis in human kidney: Potential for differentiation, 490 formation of a potent mineralocorticosteroid in its site of action, 7069 Lepomis macrochirus Distal nephron of rat kidney: A target site for glucagon, 3422 Alternative male life histories in bluegill sunfish, 6937 y-Glutamylamine cyclotransferase: Specificity toward Leptinotarsin e-(L--y-glutamyl)-L-lysine and related compounds, 4564 Leptinotarsin: A presynaptic neurotoxin that stimulates release of Kidney tissue: Role in production of 25-hydroxyvitamin D3-26,23-lactone acetycholine, 1219 and la,25-dihydroxyvitamin D3-26,23-lactone, 6411 Leucine Membrane-bound kallikrein and renin in the kidney: Activation, 4975 Isovaleryl-CoA dehydrogenase: Demonstration in rat liver mitochondria Kinetic proofreading by ion-exchange chromatography and isoelectric focusing, 2646 Energy relay: A proofreading scheme based on dynamic cooperativity Preprotein processing: Inhibition in ascites tumor lysates by and lacking all characteristic symptoms of kinetic proofreading in incorporationof a leucine analog,1356 DNA replication and protein synthesis, 5248 Leukemia Kinetoplast see also Cell, leukemia Sequences of two kinetoplast DNA minicircles of Trypanosoma brucei, AKR leukemogenesis: Inhibition by SMX-1, a dualtropic murine 2445 leukemiavirus, 3720 Trypanosoma cruzi: Strains and clones can be characterized by pattern Cellular sequences are present in presumptive avian myeloblastosis virus of restriction endonuclease products of kinetoplast DNA minicircles, genome,5177 6810 Constitutiveuncoupling of pathwaysof gene expressionthat control Kin selection growthand differentiationin myeloid leukemia:Model for originand Kin selection: Effect of phenotypic variation, 7506 progression of malignancy, 6152 Klebsiella Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs Immunochemical determination of configuration of a haptenic toward malignant human lymphoblasts in vitro and toward murine substituent, 4244 L1210 leukemia in vivo, 6865 Klebsiella aerogenes In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity Synthesis of glutamine synthetase regulated by PII protein in Klebsiella to AKR leukemia, 2178 aerogenes, 2636 Poly(ADP-ribose) synthesis, a marker of granulocyte differentiation, Klebsiella pneumoniae 3682 Blue-green algae nitrogen fixation gene: Identification by using Proviral genome associated with avian myeloblastic leukemia, 3004 heterologous DNA hybridization probes, 186 T-cell lines established from human T-lymphocytic neoplasias by direct Electron transport to nitrogenase in Klebsiella pneumoniae, 2555 response to T-cell growth factor, 6815 Iron proteins from the nitrogen fixation complexes of Azotobacter Leukemiavirus, avian vinelandii, Clostridium pasteurianum, and Klebsiella pneumoniae, OK10,an avian acute leukemiavirus of the MC29subgroup with a 3826 unique genetic structure, 7142 Nitrogenase genes: Interspecies homology, 191 Target cell specificity of defective avian leukemia virus: Hematopoietic target cells for a given virus type can be infected but not transformed a- by strains of a different type, 389 Cyclic AMP as a negative regulator of hormonally induced lactogenesis Leukemiavirus, bovine in mouse mammary gland organ culture, 2093 Genomic integration of bovine leukemia provirus: Comparison of Lactate persistent lymphocytosis with lymph node tumor form of enzootic Electrochemical proton gradient generated in Streptococcus cremoris by bovine leukosis, 2577 lactate efflux, 5502 Leukemiavirus, Friend Lactate dehydrogenase Antibody directed against Friend leukemia virus stimulates DNA Embryonic-fetalerythroid characteristics of a humanleukemic cell line, synthesis in subpopulation of mouse B lymphocytes, 1486 3509 Kinetics of erythroid precursors in mice infected with anemic or Germinal mutation detection in vivo with monospecific antibody against polycythemic strain of Friend leukemia virus, 2054 lactate dehydrogenase-X, 7352 Variationsin propertiesof virus releasedfrom morphologicallydifferent Lactate dehydrogenase(EC 1.1.1.27) cell lines transformed in vitro by Friend leukemia virus, 5769 Active center of D- and L-lactate dehydrogenases: Studies using Leukemiavirus, Gross oxamate-diaminohexyl-Sepharose affinity chromatography, 5832 Most sequence differences between genomes of Akv virus and a Affinity chromatography in nonionic detergent solutions, 5847 leukemogenic Gross A virus passaged in vitro are located near the 3' Permeabilization of animal cells for kinetic studies of intracellular terminus, 4359 enzymes: In situ behavior of glycolytic enzymes of erythrocytes, 6324 Leukemiavirus, Moloney D-Lactatedehydrogenase (EC 1.1.1.28) Nucleotide sequence of Moloney leukemia virus: 3' End reveals details of Active center of D- and L-lactate dehydrogenases: Studies using replication,analogy to bacterialtransposons, and an unexpectedgene, oxamate-diaminohexyl-Sepharose affinity chromatography, 5832 3302 Lactogenesis Passive immunotherapy prevents expression of endogenous Moloney Cyclic AMP as a negative regulator of hormonally induced lactogenesis virus and amplification of proviral DNA in BALB/Mo mice, 3677 in mouse mammary gland organ culture, 2093 Structure of a cloned circular Moloney murine leukemia virus DNA Laminin moleculecontaining an invertedsegment: Implications for retrovirus Inductionof basementmembrane glycoprotein in embryonickidney: integration, 3932 Possible role of laminin in morphogenesis, 485 Structure of Moloney murine leukemia viral DNA: Nucleotide sequence Lamprey of the 5' long terminal repeat and adjacent cellular sequences, 3307 see Petromyzon marinus Leukemiavirus, murine Laplace's law AKR leukemogenesis: Inhibition by SMX-1, a dualtropic murine Small phospholipid vesicles: Internal pressure, surface tension, and leukemia virus, 3720 surface free enery, 4048 Akvr-1, a dominant murine leukemia virus restriction gene, is Laser polymorphicin leukemia-pronewild mice, 531 Time-resolved studies of ATP-requiring biological systems: Laser flash Cytotypically specific transfecting activity of DNA from C57BL/Ka photolysis of caged ATP, 7237 mouse cells producing thymotropic in contrast to nonthymotropic Lasioglossumzephrum retroviruses, 6189 Ambient air concentration of sulfur dioxide affects flight activity in bees, Ecotropic proviral sequences: Identification in inbred mouse strains with 5631 a cloned subgenomic DNA fragment, 5779 Lecithin Genetically dominant resistance in mice to Magneto-orientation of lecithin crystals, 7232 3-methylcholanthrene-induced lymphoma, 2960 Lecithin:cholesterolacyltransferase (EC 2.3.1.43) Germ-line reinsertions of AKR murine leukemia virus genomes in Akv-1 Cholesterylester transfercomplex in humanplasma, 3327 congeneic mice, 4871 Heterogeneityof humanhigh density lipoprotein:Presence of Gix antigen expression: Relationship to glycosylation of murine leukemia lipoproteinswith and without apoE and their roles as substratesfor virus glycoprotein, 6420 lecithin:cholesterol acyltransferase reaction, 2969 Glycosylation patterns of closely related murine leukemia viruses: Lecithin:cholesterol acyltransferase: Activation by a synthetic model Differences, 67 lipid- associating peptide, 3154 Highly efficient induction of type C retroviruses by a human tumor in Lectin athymic mice, 2247 see also Electrolectin; specific lectins Immunoselection of mutants deficient in cell surface glycoproteins Carbohydrate-binding component of amphibian embryo cell surfaces: encoded by murine erythroleukemia viruses, 57 Restriction to surface regions capable of cell adhesion, 3460 Induction of lymphoma in athymic mice: A model for study of the Differential lectin binding to cellular membranes in epidermis of human disease, 4971 newborn rats, 477 In vitro construction of a B-tropic virus by recombination: B-Tropism is Positive cooperativity in a (dissected) lectin-membrane glycoprotein a cryptic phenotype of xenotropic murine retroviruses, 2989 binding event, 3788 Isolation of BPgp70, a fibroblast receptor for the envelope antigen of Lens Rauscher murine leukemia virus, 4988 Comparisonof two b-crystallingenes in chicken,5879 Molecular cloning of infectious integrated murine leukemia virus DNA Cysteine and methionine: Selective oxidation in normal and senile from infected mouse cells, 614 cataractous lenses, 1274 Downloaded by guest on September 29, 2021 7578 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Molecular dissection of Rauscher virus gp70 by using monoclonal Lipoprotein,low density antibodies: Localization of acquired sequences of related envelope gene see also Receptor,low density lipoprotein recombinants, 4524 Coronaryatherosclerosis associated with hyperapobetalipoproteinemia Molecular genetics of carcinogenesis in rats: Model, 3450 [increasedprotein but normalcholesterol levels in humanplasma low Nucleotide sequences associated with differences in electrophoretic density (f3)lipoproteins], 604 mobility of envelope glycoprotein gp70 and with GIx antigen Inhibitionof Ca2+accumulation in mitogen-activatedlymphocytes: Role phenotype of certain murine leukemia viruses, 1642 of membrane-boundplasma lipoproteins, 4764 Structure of endogenous murine leukemia virus DNA in mouse genomes, Inhibitionof receptor-mediatedclearance of lysine and 5774 arginine-modifiedlipoproteins from plasmaof rats and monkeys,225 Transformation-defective mutant of Abelson murine leukemia virus Malondialdehydealteration of low density lipoproteinsleads to lacks protein kinase activity, 4993 cholesterylester accumulationin humanmonocyte-macrophages, 2214 Leukemia virus, radiation Metabolismof native and of lactosylatedhuman low density lipoprotein: Peanut agglutinin receptors expressed on virus-induced preleukemic cells Evidencefor two pathwaysfor catabolismof exogenousproteins in rat in mice, 2244 hepatocytes,5923 Leukocyte Platelet-derivedgrowth factor stimulates activity of low density Arachidonic acid: Role in stimulation of hexose transport by human lipoproteinreceptors, 4084 polymorphonuclear leukocytes, 5125 Lipoprotein,very low density Human eosinophil lysophospholipase identified as constituent of Coordinateregulation of two estrogen-dependentgenes in avian liver, Charcot-Leyden crystals, 7440 4474 Human polymorphonuclear leukocyte chemotaxis inhibited by Liposome oxygenated sterol compounds, 4313 Antigen-liposomemodification of target cells as a method to alter their Lateral distribution and diffusion of C3b receptor of complement, HLA susceptibilityto lysis by cytotoxicT lymphocytes,6105 antigens, and lipid probes in peripheral blood leukocytes, 6587 Diphtheriatoxin: Bindingto phospholipidsin liposomes,1986 Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl Generalmethod, employing arsenazo III in liposomes,for study of platelet-activating factor, from leukocytes: Chemical ionization mass calciumionophores: Results with A23187and prostaglandins,1506 spectrometry of phospholipids, 7019 Hepatic asialoglycoproteinreceptor: Reconstitution with phospholipid Targeting of lipid vesicles: Specificity of carbohydrate receptor analogues vesicles, 5087 for leukocytes in mice, 4430 Hepatic uptake and degradationof unilamellar Leukotriene sphingomyelin/cholesterolliposomes: A kinetic study, 4030 Leukotriene D: Slow reacting substance from rat basophilic leukemia Insulin causes translocationof glucosetransport activity to plasma cells, 2014 membranefrom an intracellularstorage site, 2542 Leukotrienes C-1 and D: Comparative airway and vascular activities in Liposomes:Fusion with mitochondrialinner membranes,442 vivo and in vitro, 4354 Net proton-hydroxylpermeability of largeunilamellar liposomes Mouse peritoneal macrophages release leukotriene C in response to a measuredby an acid-basetitration technique, 2038 phagocytic stimulus, 4928 pH-dependentfusion betweenSemliki Forest virus membraneand Slow reacting substances of anaphylaxis: Identification of leukotrienes liposomes,3273 C-1 and D from human and rat sources, 3710 Positive cooperativityin a (dissected)lectin-membrane glycoprotein Leupeptin bindingevent, 3788 Carbohydraterequirement for expressionand stability of acetylcholine Reassemblyof protein-lipidcomplexes into large bilayervesicles: receptoron surfaceof embryonicmuscle cells in culture,5263 Perspectivesfor membranereconstitution, 239 Degradation process: Role in mitogenic effect of epidermal growth factor, Receptor-mediatedendocytosis of antibody-opsonizedliposomes by 1466 tumor cells, 4089 L factor Small phospholipidvesicles: Internal pressure, surface tension, and L factor required for /-galactosidase synthesis is the nusA gene product surfacefree enery, 4048 involved in transcription termination, 1991 Synthetic glycolipids:Functional incorporation into cells, 2510 Limax maximus Targetingof lipid vesicles:Specificity of carbohydratereceptor analogues Rapid taste-aversion learning by an isolated molluscan central nervous for leukocytesin mice, 4430 system, 6204 f-Lipotropichormone Limuluspolyphemus see /-Lipotropin Active center of D- and L-lactate dehydrogenases: Studies using f-Lipotropin oxamate-diaminohexyl-Sepharose affinity chromatography, 5832 Biosynthesisof precursorcorticotropin/endorphin-, corticotropin-, Lipid a-melanotropin-,/f-lipotropin-, and /-endorphin-likematerial by see also Phospholipid culturedneonatal rat hypothalamicneurons, 1880 Body-centered cubic phase of lipid systems: Structure, 6991 Humangenomic DNA encodingthe pro-opiomelanocortinpeptide: Cellular and molecular basis of increased splenic hemopoiesis in mice Structuralorganization, 4890 treated with bacterial cell wall components, 4322 Precursorto corticotropinand /-lipotropin in humans:Processing, 5211 Differentiation of a mammary cell line: Control by lipids, 1551 /-[Tyr9]Melanotropin-(9-18)decapeptide from pig hypothalami: Lateral diffusion of membrane lipids and proteins during cell cycle of Isolation,structure, biological characterization, and synthesis,3947 neuroblastoma cells, 1526 'y-Lipotropin Lateral distribution and diffusion of C3b receptor of complement, HLA 'y-Lipotropinfrom humanpituitary glands: Isolation and amino acid antigens, and lipid probes in peripheral blood leukocytes, 6587 sequence,7214 Lipid fluidity markedly modulates binding of serotonin to mouse brain Lipoxygenase membranes, 7463 Arachidonatemetabolism via lipoxygenaseand Mechanism of capacitation: Albumin-mediated changes in plasma 12L-hydroperoxy-5,8,10,14-icosatetraenoicacid peroxidasesensitive to membrane lipids during in vitro incubation of rat sperm cells, 1546 anti-inflammatorydrugs, 308 Membrane lipid physical state and modulation of Na+,Mg2+-ATPase Lithium activity in Acholeplasma laidlawii B, 1255 Erythrocytecholine concentrations are elevated in manic patients, 6144 Reconstitution of functional membrane-bound acetylcholine receptor Lithiumdodecyl sulfate from isolated Torpedo californica receptor protein and electroplax Pigment-proteincomplexes of Rhodopseudomonassphaeroides: lipids, 1796 Isolationand characterizationby lithium dodecyl Lipid-associating peptide sulfate/polyacrylamidegel electrophoresis,87 Lecithin:cholesterol acyltransferase: Activation by a synthetic model Liver lipid- associating peptide, 3154 Activationfactor of liver phosphofructokinase,5861 Lipid bilayer Agonistversus antagonist binding to a-adrenergicreceptors, 4569 Lipid phase transition in planar bilayer membrane and its effect on Calciumdependence of phalloidin-inducedliver cell death, 1177 carrier- and pore-mediated ion transport, 3403 Colchicine-sensitiveuptake system in Morrishepatomas, 5282 Rate theory calculation of gramicidin single-channel currents using Coordinateregulation of two estrogen-dependentgenes in avian liver, NMR-derived rate constants, 2028 4474 Reconstitution of purified acetylcholine receptors with functional ion Differencesin organizationalstructure of insulin receptoron rat channels in planar lipid bilayers, 3057 adipocyteand liver plasmamembranes: Role of disulfidebonds, 4692 Scanning calorimetric evidence for a third phase transition in Differenthalf-lives of carbohydrateand proteinmoieties of a phosphatidylcholine bilayers, 5060 110,000-daltonglycoprotein isolated from plasmamembranes of rat Lipogenesis liver, 1828 Regulation of acetyl-CoA carboxylase: Properties of CoA activation of Digitalis metabolismand humanliver alcoholdehydrogenase, 924 acetyl-CoA carboxylase, 3351 Enhanceddrug-metabolizing capacity within liver adjacentto human Lipopolysaccharide and rat liver tumors,600 Membrane potential changes during mitogenic stimulation of mouse Fetal rat liver cell line establishedthat retainsdifferentiated liver spleen lymphocytes, 2200 functions,2731 Lipoprotein Hepatic uptake and degradationof unilamellar see also Apolipoprotein;Gene, lipoprotein sphingomyelin/cholesterol liposomes: A kinetic study, 4030 Cellularand molecularbasis of increasedsplenic hemopoiesisin mice Independent lines of evidence suggesting a major gap junctional protein treated with bacterialcell wall components,4322 with a molecularweight of 26,000,970 Cholesteryl ester transfer complex in human plasma, 3327 Isoprotein specificity in hepatic uptake of apolipoprotein E and Lipoprotein,high density pathogenesis of familial dysbetalipoproteinemia, 4349 Amyloid-related apoprotein (SAA) from human high density lipoprotein: Metal clusters in rabbit liver metallothionein: Structure, 7094 Isolation and characterization, 6860 Organ chemiluminescence: Noninvasive assay for oxidative radical Heterogeneity of human high density lipoprotein: Presence of reactions, 347 lipoproteins with and without apoE and their roles as substrates for Plasminogen:Production and releaseby isolated perfusedrat liver, 6837 lecithin:cholesterol acyltransferase reaction, 2969 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7579

Prostaglandin 12 modifies both prolactin binding capacity and fluidity of Lymphocyte,T mouse liver membranes, 6597 see Cell, T Uptake of free choline by isolated perfused rat liver, 4417 Lymphocsis, persistent Lizard Genomic integration of bovine leukemia provirus: Comparison of see Cnemidophorus persistent lymphocytosis with lymph node tumor form of enzootic Lobeline bovine leukosis, 2577 Attempt to distinguish between actions of neuromuscular blocking drugs Lymphoma on the acetylcholinereceptor and on its associatedionic channel,5003 Crohn disease lymph node homogenates produce murine lymphoma in Loligopealei athymic mice, 588 Currentrecorded from a cut-opengiant axon undervoltage clamp, 7484 Genetically dominant resistance in mice to Polypeptide composition of squid neurofilaments, 404 3-methylcholanthrene-induced lymphoma, 2960 Lophius americanus Induction of lymphoma in athymic mice: A model for study of the Biosynthesis in vitro of fish islet preprosomatostatin: Processing and human disease, 4971 segregation of a high molecular weight precursor, 4074 T-cell lines established from human T-lymphocytic neoplasias by direct Luciferase response to T-cell growth factor, 6815 Physical interaction and activity coupling between two enzymes induced Type C retrovirus particles: Detection and isolation from fresh and by immobilization of one, 249 cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proteolytic inactivation of luciferases from three species of luminous 7415 marine bacteria, Beneckea harveyi, Photobacterium fischeri, and Lysine Photobacterium phosphoreum: Evidence of a conserved structural Anion binding sites on cytochrome c: Mapping by differential chemical feature,6363 modification of lysine residues, 4439 Luciferin Interaction between cytochrome b5 and hemoglobin: Involvement of /66 Crossreactivity between light-emitting systems of distantly related (E10) and /95 (FG2) lysyl residues of hemoglobin, 1917 organisms: Novel type of light-emitting compound, 1394 Lysine,trimethyl- Luliberin Calmodulin from spinach leaves and in vitro translation mixtures: Peptidergictransmission in sympatheticganglia, 5008 Isolation and characterization, 1912 Similar luteinizing hormone-releasing hormone binding sites in rat Lysolecithin anterior pituitary and ovary, 5567 Membrane-bound kallikrein and renin in the kidney: Activation, 4975 Luminescence Lysophospholipase (EC 3.1.1.5) see also Bioluminescence Human eosinophil lysophospholipase identified as constituent of Carbon monoxide hemocyanins: Luminescence, 2387 Charcot-Leyden crystals, 7440 Magnetic field-induced increase in chlorophyll a delayed fluorescence of Lysosome photosystem II: A 100- to 200-ns component between 4.2 and 300 K, Aminopeptidase allele frequency dine maintained by natural selection, 5889 5385 Lung surfactant Anion channel blockers inhibit lysosomal enzyme secretion from human Acid phosphatase in pulmonary surfactant: Properties, 808 neutrophils without affecting generation of superoxide anion, 2721 Luteinizing hormone Experimental animal model for mucopolysaccharidosis: Suramin-induced see Lutropin glycosaminoglycan and sphingolipid accumulation in rats, 3700 Luteinizinghormone-releasing factor Human lysosomes can be purified from diploid skin fibroblasts by see Luliberin free-flow electrophoresis, 6139 Lutropin In vitro synthesis of pre-proteins of vacuolar compartmented proteinase Aggregation of luteinizing hormone receptors in granulosa cells: Possible inhibitors that accumulate in leaves of wounded tomato plants, 1975 mechanism of desensitization to the hormone, 3440 Phosphorylated in lysosomal enzymes: Identification of Blockade of recruitment of ovarian follicles by suppression of secondary a-N-acetylglucosamine(l)phospho(6)mannose diester groups, 7074 surge of follicle-stimulating hormone with porcine follicular fluid, 4953 Prostaglandin synthesis by macrophages requires a specific Hormone-induced guanyl nucleotide binding and activation of adenylate receptor-ligandinteraction, 4279 cyclase in Leydig cell, 5837 Sanfilippo disease type D: Deficiency of N-acetylglucosamine-6-sulfate Oligosaccharide moieties of glycoprotein hormones: Bovine lutropin sulfatase required for degradation, 6822 resists enzymatic deglycosylation because of terminal O-sulfated Lysozyme N-acetylhexosamines, 7089 Electron paramagnetic resonance spectroscopy of Cu2+ in hen egg-white Opiate regulation of estradiol-2-hydroxylase in brains of male rats: lysozyme, 5243 Mechanism for control of pituitary hormone secretion, 2574 Exons encode functional and structural units of chicken lysozyme, 5759 Lycopersicumesculentum In vitro synthesis of pre-proteins of vacuolar compartmented proteinase Macaca mulatta' inhibitors that accumulate in leaves of wounded tomato plants, 1975 Silent 1-globin gene in Old World monkeys, 3563 Lymph Macaca nemestrina Apolipoprotein B variant derived from rat intestine, 3806 Sex steroid-binding protein of plasma: Immunocytochemical localization Lymphnode tumor in tissues of adult monkey Macaca nemestrina, 5678 Genomic integration of bovine leukemia provirus: Comparison of Macrophage persistent lymphocytosis with lymph node tumor form of enzootic Low density lipoprotein receptor activity in human monocyte-derived bovine leukosis, 2577 macrophages and its relation to atheromatous lesions, 5466 Lymphoblast Mouse peritoneal macrophages release leukotriene C in response to a see also Cell, lymphoblastoid phagocytic stimulus, 4928 Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs Neutral protease activation of peritoneal macrophage prostaglandin toward malignant human lymphoblasts in vitro and toward murine synthesis, 4736 L1210 leukemia in vivo, 6865 Plasma membrane polypeptides of resident and activated mouse Isolation of diploid human lymphoblast mutants presumably peritoneal macrophages, 2188 homozygous for ouabain resistance, 1101 Plasminogen activator secretion in macrophages induced by Lymphocyte electrochemical stimulation of hexose monophosphate shunt with Activation of early enzyme production in small lymphocytes in response methylene blue, 414 to high, nonmitogenic concentrations of concanavalin A, 3479 Prostaglandin synthesis by macrophages requires a specific Antigen-specific induction and regulation of antibody synthesis in receptor-ligand interaction, 4279 cultures of human peripheral blood mononuclear cells, 1139 Resistance of simian virus 40-transformed hamster cells to cytolytic Appearance of cytoskeletal components on the surface of leukemia cells effect of activated macrophages: Possible factor in species-specific viral and of lymphocytes transformed by mitogens and Epstein-Barr virus, oncogenicity, 6773 4979 Switching on the macrophage-mediated suppressor mechanism by tumor Cyclic AMP metabolism modulated by S-adenosylhomocysteine and cells to evade host immune surveillance, 4265 S-3-deazaadenosylhomocysteine in mouse lymphocytes, 5639 Macularcorneal dystrophy Human soluble suppressor factor affecting lymphocyte responses in Macular corneal dystrophy: Failure to synthesize a mature keratan vitro, 6096 sulfate proteoglycan, 3705 I and i antigens of human peripheral blood lymphocytes cocap with Magnesium receptors for concanavalin A, 376 Major intracellular cations and growth control: Correspondence among Inhibition of Ca2+ accumulation in mitogen-activated lymphocytes: Role magnesium content, protein synthesis, and onset of DNA synthesis in of membrane-bound plasma lipoproteins, 4764 BALB-c 3T3 cells (correction),1721 Lymphocyte surface properties altered by insertion of foreign functional Noninvasive 31p NMR probes of free Mg2+, MgATP, and MgADP in components of plasma membrane, 7247 intact Ehrlich ascites tumor cells, 2487 Membrane potential changes during mitogenic stimulation of mouse Magneticfield spleen lymphocytes, 2200 Magnetic field-induced increase in chlorophyll a delayed fluorescence of Microtubule assembly and concanavalin A capping in lymphocytes: photosystem II: A 100- to 200-ns 'component between 4.2 and 300 K, Reappraisal using normal and abnormal human peripheral blood cells, 5889 3499 Magnetic fields produced by steady currents in the body, 1447 Nucleic acid spot hybridization: Rapid quantitative screening of Magneto-orientation of lecithin crystals, 7232 lymphoid cell lines for Epstein-Barr viral DNA, 6851 Magneticmoment Phospholipid methylation: A biochemical signal modulating lymphocyte Magneticmoment of carbonmonoxide hemoglobin from carp: mitogenesis, 862 Variability, 1462 Target selectivity of interferon-induced human killer lymphocytes Maize related to their Fc receptor expression, 3620 see also Zea mays Lymphocyte,B Asynchronous replication of heterochromatin in maize, 6705 see Cell, B Downloaded by guest on September 29, 2021 7580 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Genetic regulation of catalase developmental program in maize Meganyctiphanesnorvegica scutellum: Identification of a temporal regulatory gene, 5360 Crossreactivitybetween light-emitting systems of distantly related Majorhistocompatibility complex organisms:Novel type of light-emittingcompound, 1394 see also Antigen, histocompatibility Meiosis Allelic forms of 02- in mouse, 7395 Associationof ribosomalgenes in fibrillarcenter of nucleolus:A factor Antigen-liposome modification of target cells as a method to alter their -influencingtranslocation and nondisjunctionin humanmeiotic oocyte, susceptibility to lysis by cytotoxic T lymphocytes, 6105 6017 During ontogeny, Ia-bearing accessory cells are found early in the Extrachromosomalgenetic elements:Preferential inclusion in yeast thymus but late in the spleen, 1597 meiotic spores,5380 H-2 restriction: Independent recognition of H-2 and foreign antigen by a Meiotic synthesisof testis histones in rats, 371 single receptor, 2192 Quantitationof mRNAs duringmouse spermatogenesis:Protamine-like Inherited structural polymorphism of the fourth component of human histone and phosphoglyceratekinase-2 mRNAs increaseafter meiosis, complement, 3576 6086 Interaction between I region loci influences expression of a cell surface Ia Relationshipsamong chromatid interchanges, sister chromatid antigen, 5404 exchanges, and meiotic recombination in Drosophila melanogaster, In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity 1575 to AKR leukemia, 2178 Synaptonemal complexes are premeiotic interphase in mouse Murine T cell Ia antigens: Specificity Iat.46 maps in I-J to I-E spermatocyte, 6720 chromosomal segment of H-2 complex, 6783 Yeast ribosomal RNA genes: Replication and meiotic transmission, 6739 Partial amino acid sequences of murine fourth component of Melanocyte complement (C4): Demonstration of homology with human C4 and Serological survey of normal humans for natural antibody to cell surface identification of the amino-terminal subunit in pro-C4, 4275 antigens of melanoma, 4260 Polymorphism of human B-cell alloantigens: Evidence for three loci a-Melanocyte-stimulatinghormone within the HLA system, 6101 see a-Melanotropin Unequal crossing over within mouse T/t complex, 6077 Melanoma Malaria Cell surface antigens of human malignant melanoma: Definition of six Anti-gamete monoclonal antibodies synergistically block transmission of antigenic systems with mouse monoclonal antibodies, 6114 malaria by preventing fertilization in mosquito, 6797 Cell surface protein, p97, identified in human melanomas and certain Stage-specific proteins and glycoproteins of Plasmodium falciparum: other neoplasms, 2183 Identification of antigens unique to schizonts and merozoites, 3695 Go-G1 arrest: Role in inhibition of tumor cell growth by interferon, 1471 Malate dehydrogenase Human melanoma cell surfaces: Dissection with monoclonal antibodies, see also Gene, malate dehydrogenase 7287 Malate dehydrogenase(oxaloacetate-decarboxylating) (NAD+) (EC [4-Norleucine, 7-D-]-a-melanocyte-stimulating hormone: A 1.1.1.40) highly potent a-melanotropin with ultralong biological activity, 5754 cis-Active regulatory gene in mouse: Direct demonstration of cis-active Serological survey of normal humans for natural antibody to cell surface control of rate of enzyme subunit synthesis, 4193 antigens of melanoma, 4260 Malate synthase (EC 4.1.3.2) a-Melanotropin Glyoxylate cycle in toad urinary bladder: Possible stimulation by Biosynthesis of precursor corticotropin/endorphin-, corticotropin-, aldosterone, 1521 a-melanotropin-, /-lipotropin-, and /-endorphin-like material by Male sterility, cytoplasmic cultured neonatal rat hypothalamic neurons, 1880 Nuclear and cytoplasmic genes controlling synthesis of variant [4-Norleucine, 7-D-phenylalanine]-a-melanocyte-stimulating hormone: A mitochondrial polypeptides in male-sterile maize, 418 highly potent a-melanotropin with ultralong biological activity, 5754 Malic enzyme 8-Melanotropin see Malate dehydrogenase(oxaloacetate-decarboxylating) (NAD+) - [Tyr9]Melanotropin-(9-18)decapeptide from pig hypothalami: Malondialdehyde Isolation,structure, biological characterization, and synthesis, 3947 Malondialdehyde alteration of low density lipoproteins leads to Melatonin cholesteryl ester accumulation in human monocyte-macrophages, 2214 Circadian rhythms of melatonin release from individual superfused Mammarygland chicken pineal glands in vitro, 2319 Absolute requirement of glucocorticoid for expression of the casein gene Pteridines as nonretinal regulators of light-dependent melatonin in presence of prolactin, 6003 biosynthesis, 2415 Cyclic AMP as a negative regulator of hormonally induced lactogenesis Retinal rhythms in chicks: Circadian variation in melatonin and in mouse mammary gland organ culture, 2093 serotonin N-acetyltransferase activity, 4998 Manducasexta Melittin Neuroendocrine regulation of corpus allatum activity in Manduca sexta: Membrane-boundkallikrein and renin in the kidney:Activation, 4975 Sequential neurohormonal and nervous inhibition in the last-instar Two species of full-length cDNA are synthesized in high yield by larva, 4407 melittin-treated avian retrovirus particles, 847 Manganese Membrane Calcium channels: Involvement in short-term desensitization of see also Escherichia coli membrane; Lipid bilayer muscarinic receptor-mediated cyclic GMP formation in mouse Phospholipids as molecular instruments of ion and solute transport in neuroblastoma cells, 6897 biological membranes, 257 Purification of a manganese-containing protein involved in Membraneassembly photosynthetic oxygen evolution and its use in reconstituting an active Mechanisms of membrane assembly: Effects of energy poisons on membrane, 957 conversion of soluble M13 coliphage procoat to membrane-bound coat Manic-depressiveillness protein, 827 Erythrocyte choline concentrations are elevated in manic patients, 6144 Membrane,basement' Mannose Heparansulfate-containing proteoglycan isolated from basement Defect in structure of type I procollagen in a patient who had membrane, 4494 osteogenesis imperfecta: Excess mannose in COOH-terminal Induction of basement membrane glycoprotein in embryonic kidney: propeptide, 6179 Possible role of laminin in morphogenesis, 485 Mannose: Transfer from GDP-mannose to lipid-linked oligosaccharide Structural basis for apparent heterogeneity of collagens in human by soluble mannosyl transferase, 2524 basement membranes: Type IV procollagen contains two distinct Natural cytotoxic cells against solid tumors in mice: Blocking of chains, 745 by D-mannose, 2895 Membrane,bilayer cytotoxicity and Phosphorylated oligosaccharides in lysosomal enzymes: Identification of Compositional domain structure in phosphatidylcholine-cholesterol diester groups, 7074 sphingomyelin-cholesterol bilayers, 4055 a-N-acetylglucosamine(l)phospho(6)mannose in Trypanosoma brucei brucei: Inhibition of glycosylation of major variable Functional acetylcholine receptor from Torpedo marmorata planar surface coat glycoprotein by tunicamycin, 1529 membranes, 3052 Mannosyltransferase Membranebiogenesis Mannose: Transfer from GDP-mannose to lipid-linked oligosaccharide CytochromeP-450: Synthesisand insertioninto endoplasmicreticulum by soluble mannosyl transferase, 2524 membranes,965 Mass spectrometry Membrane;brain Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl Adenosine receptors in brain membranes: Binding of platelet-activating factor, from leukocytes: Chemical ionization mass N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine, spectrometry of phospholipids, 7019 5547 Retinoyl /-glucuronide: Characterization as a minor metabolite of Lipid fluidity markedly modulates binding of serotonin to mouse brain retinoic acid in bile, 3230 membranes, 7463 Sequence determination of protected oligodeoxyribonucleotides Putative central purinergic receptors: Biochemical characterization by containing phosphotriester linkages by californium-252 plasma using 2-chloro[3H]adenosine, a stable analog of adenosine, 6892 desorption mass spectrometry, 735 Solubilizationof active opiate receptors,4623 Mastigocladuslaminosus Membrane,cell "Living electrode" as a long-lived photoconverter for biophotolysis of Acetylcholinereceptor-controlled ion translocationacross cell water, 2442 membranes:Molecular mechanism, 842 Measles virus Animal cell membrane mutants altered in phosphatidylcholine synthesis: Antibody-independent activation of alternative complement pathway by Autoradiographicdetection, 5192 measles virus-infected cells, 559 Effect of bleachinglight on measurementsof lateraldiffusion in cell Chronic, relapsing myelitis in hamsters associated with experimental membranesby fluorescencephotobleaching recovery method, 2043 measles virus infection, 4297 Immunoselectionof mutants deficientin cell surfaceglycoproteins Cloning of DNA complementary to measles virus mRNA encoding encodedby murineerythroleukemia viruses, 57 nucleocapsid protein, 3686 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7581

Membrane-activedrugs potentiate killing of tumor cells by Differenthalf-lives of carbohydrateand protein moieties of a D-glucosamine,1172 110,000-dalton glycoprotein isolated from plasma membranes of rat Vinculin,an intracellularprotein localizedat specializedsites where liver, 1828 microfilamentbundles terminate at cell membranes,4127 Electrophoretic resolution of three major insulin receptor structures with Membrane,chromatophore unique subunit stoichiometries,7137 Electrontunneling process and segment mobility of macromolecules, Glucocorticoidhormones increase activity of plasmamembrane alkaline 7218 phosphodiesterase I in rat hepatoma cells, 1005 Membranecrystallization Insulin causes translocation of glucose transport activity to plasma Orthorhombictwo-dimensional crystal form of purple membrane,338 membranefrom an intracellularstorage site, 2542 Membranedifferentiation Kinetics of membraneinternalization and recyclingduring pinocytosis in Membranedifferentiation in humanerythroid cells: Unique profilesof Dictyostelium discoideum, 1015 cell surfaceglycoproteins expressed in erythroblastsin vitro from Lynphocyte surface properties altered by insertion of foreign functional three ontogenicstages, 3474 ,components of plasma membrane, 7247 Membrane,disc Mechanism of capacitation: Albumin-mediated changes in plasma Additionalcomponent required for activity and reconstitutionof membrane lipids during in vitro incubation of rat sperm cells, 1546 light-activatedvertebrate photoreceptor GTPase,. 1408 Model for cappingderived from inhibitionof surfacereceptor capping by Membrane,erythrocyte free fatty acids, 437 /-Adrenergicreceptor in frog erythrocytemembranes: Cytoskeletal Plasma membrane polypeptides of resident and activated mouse constraint,6401 peritoneal macrophages, 2188 /-Adrenergicreceptors and guaninenucleotide sites: Interactionin Protein encoded.bytransforming gene of avian sarcomavirus (pp60Src) turkey erythrocytemembranes, 3801 and a homologous protein in normal cells (pp60Proto-src)are associated Anchorageof a band 3 populationat erythrocytecytoplasmic membrane with plasma membrane, 3783 surface:Protein rotationaldiffusion measurements, 4702 Virus structural proteins and protein-protein interactions: Distribution Effect of cetiedil on erythrocytesickling: New type of antisicklingagent in plasmamembrane of baby hamsterkidney cells infected with that may affect erythrocytemembranes, 2955 Sindbis or vesicular stomatitis virus, 7277 Enhancementof phospholipidtransfer from Sendai virus to erythrocytes Membranepore is mediatedby target cell membrane,804 Lipid phase transition in planar bilayer membrane and its effect on Functionaldomains of human,erythrocytespectrin, 6592 carrier-and pore-mediatedion transport,3403 Human erythrocyteglucose transporter: Immunological identification,, Membranepotential 5725. Membranepotential changesduring mitogenic stimulation of mouse Interactionof oxy- and deoxyhemoglobinswith erythrocytemembrane: spleen lymphocytes, 2200. Kinetic study, 7147 Ouabain-resistant hyperpolarization induced by insulin in aggregates of Lateralmobility of band 3 in humanerythrocyte membrane studied by embryonic heart cells, 3062 fluorescencephotobleaching recovery: Control by cytoskeletal Presynaptic membrane potential affects transmitter release in an interactions,2537 identified neuron in Aplysia by modulating Ca2+ and K+ currents, 629 Membraneprotein lateral mobility:Modulation by polyphosphatesand T lymphocytecholinergic receptors: Electrophysiology, 4317 polyamines,1457 Membraneprotein Multiple componentsof blood groupA and B antigensin human see also specific proteins erythrocytemembranes and their differencebetween A1 and A2status, Anchorage of a band..3 population at erythrocyte cytoplasmic membrane 2951 surface: Protein rotational diffusion measurements, 4702 Oligosaccharidemotion in erythrocytemembranes investigated by Apical membraneaminopeptidase appears at site of cell-cell contact in picosecondfluorescence polarization and microseconddichroism of an culturedkidney epithelial cells, 4132 optical.probe,5899 Charge selectivity at lipid-protein interface of membranous Phosphorylationand dephosphorylationof spectrinfrom human Na,K-ATPase, 272 erythrocyteghosts underphysiological conditions: Autocatalysis rather Coated pits act as molecular filters, 4156 than reactionwith separatekinase and phosphatase,3264 Differences in intracellular location of pp60Srcin rat and chicken cells Stage-specificproteins and glycoproteinsof Plasmodiumfalciparum: transformed by Rous sarcoma virus, 4142 Identificationof antigensunique to schizontsand merozoites,3695 Independentlines of evidence suggestinga majorgap junctionalprotein Membrane,fibroblast with a molecularweight of 26,000,970 Corrugatedattachment membrane in WI-38fibroblasts: Alternating Intracellularprotein topogenesis, 1496 fibronectinfibers and actin-containingfocal contacts,4108 Lateraldiffusion of membranelipids and proteinsduring cell cycle of Membranefusion neuroblastoma cells, 1526 Anion channelblockers inhibit lysosomalenzyme secretionfrom human Major lens membrane protein: Synthesis in vitro, 725 neutrophilswithout affectinggeneration of,superoxide anion, 2721 Membrane-associated required for protein translocation Lymphocytesurface properties altered by insertionof foreignfunctional across endoplasmic reticulum: Purification, 7112 componentsof plasmamembrane, 7247 Membraneprotein lateral mobility:Modulation by polyphosphatesand pH-dependentfusion betweenSemliki Forest virus membraneand polyam.ines, 1457 liposomes,3273 Molecularcloning of a human histocompatibilityantigen cDNA Membrane,microsomal fragment,6081 High-performanceliquid chromatographytechnique for resolving Nondenaturingzwitterionic detergent for membranebiochemistry: multipleforms of hepatic membrane-boundcytochrome P-450, 6473 Design and synthesis, 6368 Pyrophosphate:proteinphosphotransferase: Membrane-bound enzyme of Primarystructure of majorouter membraneprotein II* (ompAprotein) endoplasmicreticulum, 1927 of Escherichia coli K-12, 4592 Membrane,microvillus Procoat,the precursorof M13 coat protein,requires an electrochemical Monoclonalantibodies to sucrase/isomaltase:Probes for study of potential for membraneinsertion, 4669 postnataldevelopment and biogenesisof intestinal microvillus Reassembly of protein-lipid complexes into large bilayer vesicles: membrane,6629 Perspectives for membrane reconstitution, 239 Membrane,mitochondrial Regulatory region of gene for ompA protein, a major outer membrane Liposomes:Fusion with mitochondrialinner membranes,442 .protein of Escherichia coli, 3845 Mitochondrialmembrane biogenesis: Identification of precursorto yeast Simultaneous expression of mouse immunoglobulins M and D is cytochromec oxidase subunit II, an integralpolypeptide, 142 determined by the same homolog of chromosome 12, 6793 Membrane,muscle Synthesis and maturation of X receptor in Escherichia coli K-12: In vivo Single channelcurrents from excised patches of muscle membrane,6930 and in vitro expression of gene lamB under lac promoter control, 1491 Membrane,nerve Three-dimensional crystals of membrane proteins: Bacteriorhodopsin, Protein phosphorylationand sodium conductancein nerve membrane, 1283 812 Vesicular stomatitis virus glycoprotein is anchored in viral membrane by Membranepermeability a hydrophobic domain near the COOH terminus, 3884 Abnormalnet Na+ and K+ fluxes in erythrocytesof three varietiesof Membrane,purple geneticallyhypertensive rats, 4283 Bacteriorhodopsinis an inside-outprotein, 5894 Cytoskeletonof digitonin-treatedrat hepatocytes,3430 Chromophore:Location in bacteriorhodopsin,4726 Kinetic models suggest bimolecularreaction steps in axonal Na+-channel Delipidationof bacteriorhodopsinand reconstitutionwith exogenous gating, 6582 phospholipid, 323 Membranepermeability: Control by externaland internalATP in 3T6 Delipidationof bacteriorhodopsinand reconstitutionwith exogenous cells grownin serum-freemedium, 2103 phopholipid(correction), 2353 Membrane,plasma Exchangekinetics of Schiff base proton in bacteriorhodopsin,6571 Activationof pyruvatedehydrogenase by direct addition of insulin to an Orthorhombictwo-dimensional crystal form of purple membrane,338 isolated plasmamembrane/mitochondria mixture: Generation of Path of the polypeptide in bacteriorhodopsin, 2023 insulin'ssecond messengerin a subcellularsystem, 77 Surface charge changes in purple membranes and the photoreaction Anioniclipid domains:Correlation with functionaltopography in a cycle of bacteriorhodopsin, 4707 mammaliancell membrane,6601 Membrane,reticulocyte Coatedpits act as molecularfilters, 4156 Agonist-promoted coupling of /-adrenergic receptor with guanine Coatedvesicles transportnewly synthesizedmembrane glycoproteins . nucleotide regulatory protein of the adenylate cyclase system, 775 from endoplasmicreticulum to plasmamembrane in two successive Membrane,sarcolemma stages, 780 Saxitoxin-bindingcomponent of excitable membranesodium channel: Coordinatemodulation of D-glucosetransport activity and bilayer Purificationfrom rat sarcolemma,1306 fluidity in plasmamembranes derived from controland insulin-treated Membrane,thylakoid adipocytes,915 Chloroplastphosphoproteins: Regulation of excitation energytransfer by Differencesin organizationalstructure of insulin receptoron rat phosphorylationof thylakoidmembrane polypeptides, 5253 adipocyteand liver plasmamembranes: Role of disulfidebonds, 4692 Downloaded by guest on September 29, 2021 7582 Biological Sciences Subject Index Proc. 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Purification of a manganese-containing protein involved in Methyleneblue photosynthetic oxygen evolution and its use in reconstituting an active Plasminogenactivator secretion in macrophagesinduced by membrane, 957 electrochemicalstimulation of hexose monophosphateshunt with Membrane vesicle methyleneblue, 414 see also Liposome Methylglyoxal Acetylcholine receptor-controlled ion translocation across cell Protein-methylglyoxaladduct: Spectroscopic studies, 949 membranes: Molecular mechanism, 842 3-O-Methylmannosepolysaccharide Arrest and metastasis of blood-borne tumor cells are modified by fusion Structureof a mycobacterialpolysaccharide-fatty acyl-CoA complex: of plasma membrane vesicles from highly metastatic cells, 399 Nuclearmagnetic resonance studies, 2582 Cation translocation by Torpedo acetylcholine receptor: Direct Methyl methanesulfonate spectroscopic studies on a time scale of physiological relevance, 4509 Cell cycle-specificmutagenesis at hypoxanthine Glutathione transport by inside-out vesicles from human erythrocytes, phosphoribosyltransferaselocus in adult rat liver epithelialcells, 7377 6359 Metrizamide Naphthoquinones restore active transport of solutes and oxidative Isolationof newly replicatedchromatin by using shallowmetrizamide phosphorylation in irradiated membrane vesicles from Mycobacterium gradients,3336 phlei, 102 Mevalonate Reconstitution of functional membrane-bound acetylcholine receptor Isopentenyladenineas a mediatorof mevalonate-regulatedDNA from isolated Torpedo californica receptor protein and electroplax replication,5842 lipids, 1796 (R)-Mevalonateexcretion in humanand rat urines,5738 Sodium-dependent silicate transport in apochlorotic marine diatom Somatic cell genetic analysisof regulationof expressionof Nitzschia alba, 6386 3-hydroxy-3-methylglutarylcoenzyme A reductase,6621 Specific labeling of lac carrier protein in membrane vesicles of Mevalonolactone Escherichia coli by a photoaffinity reagent, 6319 Regulationof rat liver 3-hydroxy-3-methylglutaryl-coenzymeA reductase Tetracycline: Active efflux encoded by four genetically different in vivo:Enzyme phosphorylation as an early regulatoryresponse after tetracycline resistance determinants in Escherichia coli, 3974 intragastricadministration of mevalonolactone,6429 Torpedo acetylcholine receptor subunits as a transmembrane complex: Mevinolin Topographicstudies, 5807 Mevinolin:A highly potent competitiveinhibitor of Memory hydroxymethylglutaryl-coenzymeA reductase and a Memory neuron: Synapse microchemistry for memory component of a cholesterol-loweringagent, 3957 neuroconnective brain model, 3019 Michaelis-Mentenkinetics Mental retardation Subunit neighborinteractions in enzymekinetics: Half-of-the-sites Cord-blood tyrosine levels in full-term phenylketonuric fetus and the reactivityin a dimer,5741 "justification hypothesis", 6175 Microfilament Mepacrine see also Filament Mepacrine blocks /3-adrenergic agonist-induced desensitization in Calciumcontrol of intestinalmicrovillus cytoskeleton: Implications for astrocytoma cells, 1341 regulationof microfilamentorganizations, 6458 Metachromatic leukodystrophy Phalloidin-inducedcholestasis: Microfilament-mediated change in Complementation of in somatic hybrids of metachromatic junctionalcomplex permeability, 2229 leukodystrophy and multiple sulfatase deficiency disorder fibroblasts, Spreadingof fibroblastsin mediumcontaining cytochalasin B: 6166 Formationof lamellarcytoplasm as a combinationof several Metallothionein functionallydifferent processes, 5919 see also Gene, metallothionein Vinculin,an intracellularprotein localized at specializedsites where Ligand substitution reaction of metallothioneins with EDTA and microfilamentbundles terminate at cell membranes,4127 apo-carbonic anhydrase, 6334, /2-Microglobulin Metal clusters in rabbit liver metallothionein: Structure, 7094 Allelic forms of /2-microglobulinin mouse,7395 Methanoloxidase Microtubule Flavin semiquinone:Presence in methanoloxidase, 7099 Bioenergeticaspects and polymerlength distributionin steady-state Methionine head-to-tailpolymerization of actin or microtubules,4803 Cysteine and methionine: Selective oxidation in normal and senile Calciumand microtubuledependence for increasedornithine cataractous lenses, 1274 decarboxylaseactivity stimulatedby /-adrenergicagonists, dibutyryl Simian virus 40-transformed human fibroblasts: Reversible growth cyclic AMP, or serumin a rat astrocytomacell line, 995 arrest, 7306 Colchicineinhibits epidermalgrowth factor degradationin 3T3 cells, 480 Studies with [35S]methionine indicate that the 22,000-dalton Colchicine-sensitiveuptake system in Morrishepatomas, 5282 [Met]enkephalin-containing protein in chromaffin cells is a precursor Density-dependentstimulation and inhibitionof cell growthby agents of [Met]enkephalin, 6889 that disruptmicrotubules, 2748 Methotrexate Fast axonaltransport in presenceof high Ca2: Evidencethat Chinese hamster cell mutants deficient in dihydrofolate reductase microtubulesare not required,5909 activity: Isolation, 4216 High molecularweight polypeptides(270,000-340,000) from cultured 5-Fluorouracil-methotrexate synergy: Enhancement of cells are relatedto hog brain microtubule-associatedproteins but 5-fluorodeoxyuridylate binding to thymidylate synthase by copurifywith intermediatefilaments, 4808 dihydropteroylpolyglutamates, 5663 Microtubuleassembly and concanavalinA cappingin lymphocytes: Methotrexate-induced misincorporation of uracil into DNA, 1956 Reappraisalusing normaland abnormalhuman peripheral blood cells, Methotrexate polyglutamate synthesis by cultured human breast cancer 3499 cells, 2919 Microtubule-associatedprotein 2 (MAP2):Structure and Transformation of mammalian cells with an amplifiable dominant-acting phosphorylation,3206 gene, 3567 Microtubule-associatedproteins: A monoclonalantibody to MAP2 binds Nl'-Methoxycarbonylbiotin methyl ester to differentiatedneurons, 4741 Molecular structure and intermolecular interactions of Microtubulesand intermediatefilaments in chickengizzard cells: Nl'-methoxycarbonylbiotin methyl ester: Model for carboxybiotin, Associationas detected by double immunofluorescence,4769 1260 Microtubulesof cells: Visualizationin situ by indirect Methylamine immunofluorescence,6657 Internal thiolester bond: Evidence for presence in third component of Nucleationand kinetics of microtubuleassembly, 7302 human complement, 5764 Taxol stabilizesmicrotubules in mouse fibroblastcells, 1561 Lysomotropic amines cause intracellular accumulation of receptors for Microvillus epidermal growth factor, 3283 Calciumcontrol of intestinal microvilluscytoskeleton: Implications for Methylation regulationof microfilamentorganizations, 6458 see also Phospholipidmethylation; Protein methylation Miniatureendplate current Attractants and repellents control demethylation of methylated see also Endplatecurrent chemotaxis proteins in Escherichia coli (correction), 2353 Acetylcholinereceptor site density affects rising phase of miniature Inhibition of receptor-mediated clearance of lysine and endplatecurrents, 3736 arginine-modified lipoproteins from plasma of rats and monkeys, 225 Miniatureendplate potential Methylation of integrated adenovirus type 12 DNA sequences in Leptinotarsin:A presynapticneurotoxin that stimulatesrelease of transformed cells is inversely correlated with viral gene expression, 253 acetycholine,1219 Phospholipidmethylation during chemotaxis in Dictyostelium Phencyclidineinteractions with ionic channelof acetylcholinereceptor discoideum: Regulation by guanosine 3',5'-cyclic monophosphate, 6996 and electrogenicmembrane, 1224 Thermally induced biosynthesis of 2'-O-methylguanosine in tRNA from Mink cell focus-inducingvirus an extreme thermophile, Thermus thermophilus HB27, 1922 Molecular dissection of Rauscher virus gp70 by using monoclonal Methylbis(2-chloroethyl)amine antibodies: Localization of acquired sequences of related envelope gene Indicator sequence of human DNA used to study DNA damage by recombinants, 4524 methylbis(2-chloroethyl)amine, 6546 Mitochondrion Methylcholanthrene see also Deoxyribonucleic acid, mitochondrial; Membrane, mitochondrial Genetically dominant resistance in mice to Activation of pyruvate dehydrogenase by direct addition of insulin to an 3-methylcholanthrene-induced lymphoma, 2960 isolated plasma membrane/mitochondria mixture: Generation of Transformation of cultured C3H/1OT1/2 mouse embryo fibroblasts by insulin's second messenger in a subcellular system, 77 3-methylcholanthrene: Probabilistic view, 7272 Adrenocorticotropic hormone increases specific proteins of the 5-Methylcytosine mitochondrial fraction that are translated inside or outside this 5-Methylcytosine: Identification in DNA fragments immobilized on organelle in cultured adrenal tumor cells, 4648 nitrocellulose paper, 3581 Codon recognition rules in yeast mitochondria, 3167 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7583

Coupling of active ion transport and aerobic respiratory rate in isolated Monte Carlocalculation renal tubules, 447 Compositionaldomain structure in phosphatidylcholine-cholesteroland Crystallization of middle part of mitochondrial electron transfer chain: sphingomyelin-cholesterolbilayers, 4055 Cytochrome bcl-cytochrome c complex, 5084 Morphallaxis Crystallization of part of the miotchondrial electron transfer chain: Scale-invariancein reaction-diffusionmodels of spatial pattern Cytochrome c oxidase-cytochrome c complex, 928 formation,4180 Cytokinin inhibition of respiration in mitochondria from six plant Morphine species, 4731 see also Receptor,morphine Cytokinin inhibition of respiration in mitochondria from six plant Morphineand opioid peptides reduceparaventricular neuronal activity: species (correction), 6941 Studies on rat hypothalamicslice preparation,5527 Cytoplasmically made subunits of yeast mitochondrial F1-ATPase and Multiple opiate receptors:[3H]Ethylketocyclazocine receptor binding cytochrome c oxidase are synthesized as individual precursors, not as and ketocyclazocineanalgesia, 3691 polyproteins, 3998 Opiateregulation of estradiol-2-hydroxylasein brainsof male rats: Different pattern of codon recognition by mammalian mitochondrial Mechanismfor controlof pituitaryhormone secretion, 2574 tRNAs, 3164 Peptide inhibitorof morphine-and /-endorphin-inducedanalgesia, 5525 Flash-activated cyclic electron transport system constructed by using Morphogenesis bacterial reaction centers and ubiquinone-cytochrome b-cl/c segment Inductionof basementmembrane glycoprotein in embryonickidney: of mitochondria, 6339 Possible role of lamininin morphogenesis,485 Folate binding protein of mitochondria identified as dimethylglycine Synthesis of a posteriorindicator protein in normalembryos and double dehydrogenase, 4484 abdomensof Smittia sp. (Chironomidae,Diptera), 6700 Four cytoplasmically made subunits of yeast mitochondrial cytochrome c Mosquito oxidase are synthesized individually and not as a polyprotein, 4160 see Aedes aegypti Genetic code and codon reading patterns in Neurospora crassa Mossbauerspectroscopy mitochondria: Novel features based on sequences of six mitochondrial Electrontunneling process and segment mobility of macromolecules, tRNAs, 3159 7218 Isovaleryl-CoA dehydrogenase: Demonstration in rat liver mitochondria Iron-sulfurproteins: Spin-coupling model for three-ironclusters, 6574 by ion-exchange chromatography and isoelectric focusing, 2646 Mouse Liposomes: Fusion with mitochondrial inner membranes, 442 see Mus musculus;Mus musculusdomesticus; see also Chromosome, Mitochondria and sarcoplasmic reticulum as model targets for neurotoxic mouse and myotoxicphospholipases A2, 1346 Mouse,athymic Mitochondrial carbonic anhydrase, 5562 Highly efficient inductionof type C retrovirusesby a humantumor in Mitochondrial membrane biogenesis: Identification of precursor to yeast athymicmice, 2247 cytochrome c oxidase subunit II, an integral polypeptide, 142 Inductionof lymphomain athymicmice: A model for study of the Mitochondria: Localization in living cells with rhodamine 123, 990 humandisease, 4971 Nuclear and cytoplasmic genes controlling synthesis of variant Mouse,chimeric mitochondrial polypeptides in male-sterile maize, 418 Manufactureof diploid/tetraploidchimeric mice, 6012 Processing of precursors of 21S ribosomal RNA from yeast mitochondria, Mouse mammarytumor virus 1417 Humanprotein related to majorenvelope protein of murinemammary Specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in tumorvirus: Identification and characterization,1301 fibroblasts from patients with isovaleric acidemia, 580 Mouse mammarytumor virus:In vitro infectivityassay (correction),689 Steady-state properties of coupled systems in mitochondrial oxidative Mucopolysaccharidosis phosphorylation, 2681 Experimentalanimal model for mucopolysaccharidosis:Suramin-induced Two-subunit cytochrome c oxidase (cytochrome aa3) from Paracoccus glycosaminoglycanand sphingolipidaccumulation in rats, 3700 dentrificans, 196 Sanfilippodisease type D: Deficiencyof N-acetylglucosamine-6-sulfate Mitogen sulfataserequired for heparansulfate degradation,6822 Clonalanergy: Persistence in tolerant mice of antigen-bindingB Multiplesclerosis lymphocytesincapable of respondingto antigen or mitogen,1602 Chronic,relapsing myelitis in hamstersassociated with experimental Mitogenesis measles virus infection,4297 Activationof early enzymeproduction in small lymphocytesin response Multiplesulfatase deficiency disorder to high, nonmitogenicconcentrations of concanavalinA, 3479 Complementationof arylsulfataseA in somatichybrids of metachromatic Epidermalgrowth factor-induced down-regulation of receptordoes not leukodystrophyand multiplesulfatase deficiencydisorder fibroblasts, occurin HeLa cells grownin defined medium,2735 6166 Mitogenichormone-induced intracellular message: Assay and partial Multiplication-stimulatingactivity characterizationof activatorof DNA replicationinduced by epidermal Inhibitionof biologicalactivity of multiplication-stimulatingactivity by growthfactor, 112 bindingto its carrierprotein, 7252 Phospholipidmethylation: A biochemicalsignal modulatinglymphocyte Multiplication-stimulatingactivity, an insulin-likegrowth factor: mitogenesis,862 Increasedlevels in fetal rat serum,3649 Rat dendriticcells functionas accessorycells and controlproduction of a Mung bean soluble factorrequired for mitogenicresponses of T lymphocytes,5414 see Vigna radiata MitomycinC Muscimol DNA-damagingagents stimulategene expressionat specific loci in --Aminobutyricacid receptors:Autoradiographic localization in rat Escherichiacoli, 2819 cerebellum,670 Mitosis Muscle Serum protein production in hepatocyte hybridomas: Immortalization see also Cell, muscle and expression of normal hepatocyte genes, 6616 Adult myosin light chains:Synthesis by embryonicmuscle cultures, 1020 Thyrotropin preparations are mitogenic for thyroid epithelial cells in A "mute"catalytic subunit of cyclic AMP-dependentprotein kinase follicles in suspension culture, 2743 from rat muscle and its mode of activation,2492 Molecular cloning Cooperativebinding of myosin subfragment1 to Capsid protein of Semliki Forest virus has clusters of basic amino acids actin-troponin-tropomyosincomplex, 2616 and prolines in its amino-terminal region, 6376 Free radicalreduction enhanced by elevated concentrationsof ascorbic Correct splicing of a chicken ovalbumin gene transcript in mouse L cells, acid in avian dystrophicmuscle, 790 740 Identificationof an N2 line proteinof striated muscle, 3254 Epstein-Barr virus (B95-8) DNA VII: Molecular cloning and detailed Microtubulesand intermediatefilaments in chickengizzard cells: mapping, 2999 Associationas detected by double immunofluorescence,4769 Molecular cloning of infectious integrated murine leukemia virus DNA Molecularcloning of developmentallyregulated, low-abundance mRNA from infected mouse cells, 614 sequencesfrom embryonicmuscle, 4519 Molecularcloning of unintegratedMoloney mouse sarcomavirus DNA in Mutants alteringcoordinate synthesis of specific myosinsduring bacteriophageX, 1773 nematodemuscle development,852 Molecularmotion Myosinlight chain kinase:Purification from bovine cardiacmuscle, 5852 Oligosaccharidemotion in erythrocytemembranes investigated by Single channelcurrents from excised patches of muscle membrane,6930 picosecondfluorescence polarization and microseconddichroism of an Muscle fiber optical probe,5899 Can the bindingof Ca2+to two regulatorysites on troponinC determine Mollusc,hermaphroditic the steep pCa/tensionrelationship of skeletal muscle?4717 Self-fertilizationand monogenicstrains in naturalpopulations of Insulin and glucose 6-phosphatestimulation of Ca2+uptake by skinned terrestrialslugs, 684 muscle fibers, 936 Molybdenum Quercetininhibits Ca2+uptake but not Ca2+release by sarcoplasmic Alternativenitrogen fixation system in Azobactervinelandii, 7342 reticulum in skinned muscle fibers, 4435 Inbornerrors of molybdenummetabolism: Combined deficiencies of Musculardystrophy sulfite oxidaseand xanthinedehydrogenase in a patient lacking Free radical reduction enhanced by elevated concentrations of ascorbic molybdenumcofactor, 3715 acid in avian dystrophicmuscle, 790 Monocyte Mus musculus Monoclonalantibodies against human monocytes: Initial Germ-linereinsertions of AKR murineleukemia virus genomesin Akv-1 characterization,6764 congeneic mice, 4871 Monocyte-mediatedcytotoxicity: Oxidative mechanisms, 584 Intracisternal A-particle genes: Identification in genome of Mus Subpopulationsof humanperipheral granulocytes and monocytes musculusand comparisonof multiple isolates from a mouse gene expressreceptors for IgA, 3640 library, 3571 Monocyte-macrophage Mus musculusdomesticus Malondialdehydealteration of low density lipoproteinsleads to Akvr-1,a dominantmurine leukemia virus restrictiongene, is cholesterylester accumulationin humanmonocyte-macrophages, 2214 polymorphic in leukemia-prone wild mice, 531 Downloaded by guest on September 29, 2021 7584 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Mutagenesis Cooperativebinding of myosin subfragment1 to Cell cycle-specific mutagenesis at hypoxanthine actin-troponin-tropomyosin complex, 2616 phosphoribosyltransferase locus in adult rat liver epithelial cells, 7377 Cooperative binding of subfragment 1 to regulated actin: Kinetic studies, Chinese hamster cell mutants deficient in dihydrofolate reductase 7209 activity: Isolation, 4216 Cooperative equilibrium binding of myosin subfragment 1 to Correlation between DNA affinity and mutagenicity of several actin-troponin-tropomyosin complex: Theoretical model, 3186 3-amino-l-methyl-5H-pyrido[4,3-b]indoles, 1427 Mutants altering coordinate synthesis of specific myosins during Deoxyribonucleotide pools, base pairing, and sequence configuration nematode muscle development, 852 affecting bromodeoxyuridine- and 2-aminopurine-induced Myosin subfragment-2: Identification of a region susceptible to mutagenesis, 1801 proteolysis, 2010 Effect of uncouplers on radiosensitivity and mutagenicity in x-irradiated Recombinant plasmids constructed containing rat muscle actin and mammalian cells, 2702 myosin light chain DNA sequences, 960 Energy relay: A.proofreading scheme based on dynamic cooperativity Regulation of myosin self-assembly: Phosphorylation of Dictyostelium and lacking all characteristic symptoms of kinetic proofreading in heavy chain inhibits formation of thick filaments, 7292 DNA replication and protein synthesis, 5248 Myosinlight chain kinase Fecalase: A model for activation of dietary glycosides to mutagens by Myosin light chain kinase: Purification from bovine cardiac muscle, 5852 intestinal flora, 4961 Myotube Gene-directed mutagenesis in bacteriophage T7 provided by Acetylcholine receptors on myotubes: Crosslinkage and visualization with polyalkylating RNAs complementary to selected DNA sites, 2796 biotinylated a-bungarotoxin and fluorescent avidin, 4823 Inhibition of carcinogen-induced chromosomal aberrations by an Single channel currents from excised patches of muscle membrane, 6930 anticarcinogenic protease inhibitor, 3544 Mytilus edulis In utero analysis of sister chromatid exchange: Alterations in Aminopeptidase allele frequency dine maintained by natural selection, susceptibility to mutagenic damage as a function of fetal cell type and 5385 gestational age, 4784 Isolation of diploid human lymphoblast mutants presumably NAD(P)H dehydrogenase(quinone) (EC 1.6.99.2) homozygous for ouabain resistance, 1101 Increase of NAD(P)H:quinone reductase by dietary antioxidants: Kanamycin resistance transposon Tn903: Genetic and DNA sequence Possible role in protection against carcinogenesis and toxicity, 5216 analysis, 7176 NADPH-thioredoxinreductase Postreplication repair and susceptibility of Chinese hamster cells to see Thioredoxin reductase (NADPH) cytotoxic and mutagenic effects of alkylating agents, 6072 Naja naja siamensis Segment-directed mutagenesis: Construction in vitro of point mutations Three-dimensional structure of the "long" neurotoxin from cobra venom, limited to a small predetermined region of a circular DNA molecule, 2400 5375 Nalidixicacid Mutation Isopentenyladenine as a mediator of mevalonate-regulated DNA Average time until fixation of a mutant allele in a finite population replication, 5842 under continued mutation pressure: Studies by analytical, numerical, Naloxone and pseudo-sampling methods, 522 Autoradiography in vitro of opiate receptors in rat brain suggests loci of Rate of spontaneous mutation at human loci encoding protein structure, "opiatergic" pathways, 5532 6037 Morphine and opioid peptides reduce paraventricular neuronal activity: Myastheniagravis Studies on rat hypothalamic slice preparation, 5527 Antibodiesfrom myasthenicpatients that competewith cholinergic Opiate regulation of estradiol-2-hydroxylase in brains of male rats: agents for binding to nicotinic receptors, 4326 Mechanism for control of pituitary hormone secretion, 2574 a-Fetoprotein: Inhibitory effect on binding of myasthenia gravis Stress-induced release of prolactin: Blockade by dexamethasone and antibody to acetylcholine receptor, 3635 naloxone may indicate /-endorphin mediation, 666 Mycobacteriumphlei Naphthoquinone Naphthoquinones restore active transport of solutes and oxidative Naphthoquinones restore active transport of solutes and oxidative phosphorylation in irradiated membrane vesicles from Mycobacterium phosphorylation in irradiated membrane vesicles from Mycobacterium phlei, 102 phlei, 102 Mycobacteriumsmegmatis Nasopharyngealcarcinoma Structure of a mycobacterial polysaccharide-fatty acyl-CoA complex: Frequency and levels of antibodies to Epstein-Barr virus-specific DNase Nuclear magnetic resonance studies, 2582 are elevated in patients with nasopharyngeal carcinoma, 6162 Mycobacteriumtuberculosis National Academyof SciencesUSA Tuberculoprotein derived from Mycobacterium tuberculosis: National Academy of Sciences USA: Council, members, officers, Radioimmunoassay, 4301 7513 Mycoplasma Naturalselection Mycoplasmas: Phylogenetic analysis, 494 Alternative male life histories in bluegill sunfish, 6937 Mycorrhizae Nematocyte Ecological and evolutionary significance of mycorrhizal symbioses in Clone-specific cellular recognition in a sea anemone, 6667 vascular plants (A Review), 2113 Nematode Mycosisfungoides Avermectin B1a, a paralyzing anthelmintic that affects interneurons and T-cell lines established from human T-lymphocytic neoplasias by direct inhibitory motoneurons in Ascaris, 6211 response to T-cell growth factor, 6815 Neocarzinostatin Type C retrovirus particles: Detection and isolation from fresh and Chromophore and apo-protein: Roles in neocarzinostatin action, 1970 cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Nephron 7415 Distal nephron of rat kidney: A target site for glucagon, 3422 Myelin Mineralocorticoid target sites: Identification in isolated rabbit cortical Schwann cells proliferate but fail to differentiate in defined medium, nephron, 3672 6902 Nerve-musclesynapse Myelitis Early nerve-muscle synapses in vitro release transmitter over Chronic, relapsing myelitis in hamsters associated with experimental postsynaptic membrane having low acetylcholine sensitivity, 644 measles virus infection, 4297 Nervoussystem, central Myeloma see also Brain Variants of mouse myeloma X63 that express changed immunoglobulin Catecholamine biosynthetic enzymes are expressed in replicating cells of class: Isolation, 2909 peripheral but not , 6221 Myocardialinfarction Chronic, relapsing myelitis in hamsters associated with experimental Anti-mitochondrial antibody: Localization in experimental canine measles virus infection, 4297 myocardial infarcts, 6856 Diazepam receptor: Specific nuclear binding of [3H]flunitrazepam, 1195 Autoradiographic method for measuring ischemic myocardium at risk: /-Endorphin: Stability, clearance behavior, and entry into the central Effects of verapamil on infarct size after experimental coronary artery nervous system after intravenous injection of the tritiated peptide in occlusion, 6119 rats and rabbits, 4588 Myofibril Locomotor activation induced by infusion of endorphins into ventral Anchorage-independent muscle cell differentiation, 5297 tegmental area: Opiate-dopamine interactions, 2323 Phorbol 12-myristate 13-acetate: Selective effects on myofibrils and Method for preparing cultures of central neurons: Cytochemical and 10-nm filaments, 5273 immunochemical studies, 653 The 68,000-dalton neurofilament-associated polypeptide is a component Method for preparing cultures of central neurons: Cytochemical and of nonneuronal cells and of skeletal myofibrils, 1541 immunochemical studies (correction), 2353 Myogenesis Rapid taste-aversion learning by an isolated molluscan central nervous Endogenous lectin: Distribution and activity during myogenesis as system, 6204 measured with antilectin antibody, 1054 Nervoussystem, peripheral Myogenesis in vitro: Dependence on a trophic protein present in chicken Catecholamine biosynthetic enzymes are expressed in replicating cells of embryo extract, 6922 peripheral but not central nervous system, 6221 Myopathy Dopamine and depolarizing agents regulate state of phosphorylation of Isozymes of human phosphofructokinase: Identification and subunit protein I in mammalian superior cervical sympathetic ganglion, 7479 structural characterization of a new system, 62 Neuraminidase(EC 3.2.1.18) Myosin Sendai virus utilizes specific sialyloligosaccharides as host cell receptor see also Ribonucleic acid, messenger, myosin heavy chain determinants, 5693 Adenylate deaminase binding to synthetic thick filaments of myosin, Neuroblast 7186 Electrical excitability: Spectrum of properties in progeny of a single Adult myosin light chains: Synthesis by embryonic muscle cultures, 1020 embryonic neuroblast, 1676 Downloaded by guest on September 29, 2021 Proc. 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Electrical excitability: Spectrum of properties in progeny of a single.. Three-dimensionalstructure of the "long"neurotoxin from cobravenom, embryonic neuroblast (correction), 4390 2400 Neurotransmitter Crystalline ribosomes are present in brains from senile humans, 2260 see also specific neurotransmitters Neurofilament Autoradiographyin vitro of opiate receptorsin rat brain suggests loci of Polypeptide composition of squid neurofilaments, 404 "opiatergic" pathways, 5532 The 68,000-dalton neurofilament-associated polypeptide is a component Early nerve-musclesynapses in vitro releasetransmitter over of nonneuronal cells and of skeletal myofibrils, 1541 postsynapticmembrane having low acetylcholinesensitivity, 644 Neurohypophysis Intracellularinjection of catalytic subunit of cyclic AMP-dependent Immunological identification of high molecular weight forms common to protein kinase simulatesfacilitation of transmitterrelease underlying bovine neurophysin and vasopressin, 2587 behavioralsensitization in Aplysia, 7492 Neuromuscularjunction Presynapticmembrane potential affects transmitterrelease in an Acetylcholine receptor site density affects rising phase of miniature identifiedneuron in Aplysia by modulatingCa2+ and K+ currents,629 endplate currents, 3736 Neurotropism Attempt to distinguish between actions of neuromuscular blocking drugs Elongatingnerve fibers are guided by a pathwayof materialreleased on the acetylcholine receptor and on its associated ionic channel, 5003 from embryonicnonneuronal cells, 6226 Denervation increases turnover rate of junctional acetylcholine receptors, Neutral peptide-generatingprotease 2293 Fibrinogen:Cleavage by human neutrophilneutral peptide-generating Leptinotarsin: A presynaptic neurotoxin that stimulates release of protease,5448 acetycholine, 1219 Neutrophil Phencyclidine interactions with ionic channel of acetylcholine receptor Anion channelblockers inhibit lysosomalenzyme secretion from human and electrogenic membrane, 1224 neutrophilswithout affectinggeneration of superoxideanion, 2721 Neuron Fibrinogen:Cleavage by humanneutrophil neutral peptide-generating see also Axon; Ganglion; Membrane, nerve; Optic nerve protease,5448 Avermectin B1a, a paralyzing anthelmintic that affects interneurons and Free radicalsand inflammation:Superoxide-dependent activation of a inhibitory motoneurons in Ascaris, 6211 neutrophilchemotactic factor in plasma, 1159 Biosynthesis of precursor corticotropin/endorphin-, corticotropin-, PhospholipaseA2 inhibitoryprotein in rabbit neutrophilsinduced by a-melanotropin-, /-lipotropin-, and /-endorphin-like material by glucocorticoids,2533 cultured neonatal rat hypothalamic neurons, 1880 Transepithelialmigration of humanneutrophils: An in vitro model Catalytic subunit of cyclic AMP-dependent protein kinase: system, 4069 Microinjection enhances calcium action potentials of bag cell neurons Transepithelialmigration of humanneutrophils: An in vitro model in cell culture, 7487 system (correction),6941 Elongating nerve fibers are guided by a pathway of material released Newcastledisease virus from embryonic nonneuronal cells, 6226 Le interferonmRNA from humanfibroblasts, 5341 Genetic control of number of midbrain neurons in inbred Nickel strains of mice: Relationship to size and neuronal density of the Propagationof conformationalchanges in Ni(II)-substitutedaspartate striatum, 4369 transcarbamoylase:Effect of active-site ligands on regulatorychains, Graded synaptic transmission between spiking neurons, 3733 1995 Memory neuron: Operating characteristics for memory component of a Nicotiana tabacum neuroconnective brain model, 2305 Nigericin-stimulatedATPase activity in microsomalvesicles of tobacco Memory neuron: Synapse microchemistry for memory component of a callus, 5904 neuroconnective brain model, 3019 Nitrate and sulfate assimilationpathways: Regulatory coupling in Method for preparing cultures of central neurons: Cytochemical and culturedtobacco cells, 6670 immunochemical studies, 653 Nicotinamideadenine dinucleotide Method for preparing cultures of central neurons: Cytochemical and Couplingof active ion transportand aerobicrespiratory rate in isolated immunochemical studies (correction), 2353 renal tubules, 447 Microtubule-associated proteins: A monoclonal antibody to MAP2 binds Nicotinamideadenine dinucleotideanalog to differentiated neurons, 4741 Rate enhancementof reconstitutionof glyceraldehyde-3-phosphate Morphine and opioid peptides reduce paraventricular neuronal activity: dehydrogenaseby a covalentlybound coenzymeanalog, 1966 Studies on rat hypothalamic slice preparation, 5527 Nigericin Presumptive common precursor for neuronal and glial cell lineages in Nigericin-stimulatedATPase activity in microsomalvesicles of tobacco mouse hypothalamus, 4165 callus, 5904 Presumptive common precursor for neuronal and glial cell lineages in Nitrate reductase(NADH) (EC 1.6.6.1) mouse hypothalamus (correction), 6941 Nitrate and sulfate assimilationpathways: Regulatory coupling in Presynaptic inhibition in Aplysia involves a decrease in the Ca2+ current culturedtobacco cells, 6670 of the presynaptic neuron, 1185 Nitrite reductase Presynaptic membrane potential affects transmitter release in an Transformationin Agmenellumquadruplicatum, 6052 identified neuron in Aplysia by modulating Ca2+ and K+ currents, 629 Nitrogen Sensory neurons in culture: Changing requirements for survival factors Nitrate and sulfate assimilationpathways: Regulatory coupling in during embryonic development, 1199 culturedtobacco cells, 6670 Serotonin-induced hyperpolarization of an identified Aplysia neuron is Nitrogenase mediated by cyclic AMP, 5013 Electrontransport to nitrogenasein Klebsiella pneumoniae, 2555 Tyrosine administration increases striatal dopamine release in rats with Nitrogenasereductase partial nigrostriatal lesions, 4305 CyanobacterialnifH gene codingfor nitrogenasereductase: Nucleotide Vasoactive intestinal polypeptide in cholinergic neurons of exocrine sequence,6476 glands: Functional significance of coexisting transmitters for Nitrogenfixation vasodilation and secretion, 1651 Alternativenitrogen fixation system in Azobactervinelandii, 7342 Neuro-neuronalsynapse Blue-greenalgae nitrogenfixation gene: Identificationby using Quantal release of acetylcholine examined by current fluctuation analysis heterologousDNA hybridizationprobes, 186 at identified neuro-neuronal synapse of Aplysia, 1661 CyanobacterialnifH gene codingfor nitrogenasereductase: Nucleotide Neurophysin sequence,6476 Immunological identification of high molecular weight forms common to Iron proteinsfrom the nitrogenfixation complexesof Azotobacter bovine neurophysin and vasopressin, 2587 vinelandii, Clostridiumpasteurianum, and Klebsiella pneumoniae, Neurosporacrassa 3826 Deletion mutants of Neurospora crassa mitochondrial DNA and their Nitrogenasegenes: Interspecies homology, 191 relationship to "stop-start" growth phenotype, 6032 Rhizobiumnitrogen fixation: Regulation by unadenylylatedglutamine Evolutionary origins of vertebrate hormones: Substances similar to synthetaseI system, 5817 mammalian insulins are native to unicellular eukaryotes, 6184 Nitrogenmustard Genetic code and codon reading patterns in Neurospora crassa see Methylbis(2-chloroethyl)amine mitochondria: Novel features based on sequences of six mitochondrial Nitrosoguanidine,N-methyl-N'-nitro-N- tRNAs, 3159 Antipaininhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced N,N'-Dicyclohexylcarbodiimide binds specifically to a single glutamyl transformationand increaseschromosomal aberrations, 6649 residue of the proteolipid subunit of mitochondrial Cell cycle-specificmutagenesis at hypoxanthine adenosinetriphosphatases from Neurospora crassa and Saccharomyces phosphoribosyltransferaselocus in adult rat liver epithelial cells, 7377 cerevisiae, 785 Cycle-relatedtoxicity and transformationin 1OT1/2cells treated with Neurotensin N-methyl-N'-nitro-N-nitrosoguanidine,4813 Neurotensin production by a line of rat medullary thyroid carcinoma Enhancementof N-methyl-N'-nitro-N-nitrosoguanidinetransformation cells, 3741 of Syrian hamster cells by a phorbol diester is independent of sister Neurotoxin chromatid exchanges and chromosome aberrations, 7282 see also specific toxins Inhibitionof carcinogen-inducedchromosomal aberrations by an Binding of sea anemone toxin to receptor sites associated with gating anticarcinogenicprotease inhibitor, 3544 system of sodium channel in synaptic nerve endings in vitro, 1646 Postreplication repair and susceptibility of Chinese hamster cells to Leptinotarsin: A presynaptic neurotoxin that stimulates release of cytotoxic and mutagenic effects of alkylating agents, 6072 acetycholine, 1219 Nitzschia alba Mitochondria and sarcoplasmic reticulum as model targets for neurotoxic Sodium-dependent silicate transport in apochlorotic marine diatom and myotoxic phospholipases A2, 1346 Nitzschia alba, 6386 Three-dimensional structure of a protein from scorpion venom: New Norepinephrine structural class of neurotoxins, 6496 Impulse activity of locus ceruleus neurons in awake rats and monkeys is a functionof sensorystimulation and arousal,3033 Downloaded by guest on September 29, 2021 7586 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Notexin Initiation of DNA replication in a ColEl-type plasmid: Isolation of Mitochondriaand sarcoplasmicreticulum as model targets for neurotoxic mutations in ori region, 6744 and myotoxicphospholipases A2, 1346 Integrative recombination of bacteriophage X: Extent of DNA sequence Nuclearmagnetic resonance involved in attachment site function, 3220 Aminoacid side chain conformationin angiotensinII and analogs: Kanamycin resistance transposon Tn903: Genetic and DNA sequence Correlatedresults of circulardichroism and 1H nuclearmagnetic analysis, 7176 resonance,82 Leader sequences of Strongylocentrotus purpuratus histone mRNAs Cadmium-113NMR of carbonicanhydrases: Effect of pH, bicarbonate, start at a unique heptanucleotide common to all five histone genes, and cyanide,3269 1265 Cell bioenergetics:Noninvasive, nondestructive approaches, 7430 Mass spectra of partial protein hydrolysates as a multiple phase check Measurementof changesin high-energyphosphates in the cardiaccycle for long polypeptides deduced from DNA sequences: NHa-terminal by using gated 31pnuclear magnetic resonance, 3654 segment of alanine tRNA synthetase, 6531 Measurementof internalpH of yeast spores by 31p nuclearmagnetic Maternal inheritance of human mitochondrial DNA, 6715 resonance,2470 Mitochondrial DNA polymorphism: Variants detected by restriction Metal clustersin rabbitliver metallothionein:Structure, 7094 enzymes differ in nucleotide sequence rather than in methylation, 6415 Noninvasive 31p NMR probes of free Mg2+, MgATP, and MgADP in Molecular cloning of human interferon cDNA, 4003 intact Ehrlichascites tumor cells, 2487 Multivalent translational control of transcription termination at NuclearOverhauser effect in specificallydeuterated macromolecules: attenuator of ilvGEDA operon of Escherichia coli K-12, 1862 NMR assay for unusualbase pairingin transferRNA, 5659 No apparent nucleotide sequence specificity in cellular DNA juxtaposed Productsof reactioncatalyzed by purifiedrat liver guanylatecyclase to retrovirus proviruses, 7357 determinedby 31PNMR spectroscopy,5734 Nucleotide sequence analysis of transforming region and large terminal Proton longitudinalrelaxation investigation of histidyl residuesof redundancies of Moloney murine sarcoma virus, 5234 normalhuman adult and sickle deoxyhemoglobin:Existence of Nucleotide sequence and expression of Escherichia coli trpR, structural pregelationaggregates in sickle deoxyhemoglobinsolutions, 6577 gene for trp aporepressor, 7117 Rate theory calculationof gramicidinsingle-channel currents using Nucleotide sequence of a cDNA clone derived from common region of NMR-derivedrate constants,2028 avian sarcoma virus messenger RNA: Unusual features, 176 Rat heart analyzedin vivo by phosphorusnuclear magnetic resonance, Nucleotide sequence of a cloned structural gene coding for a precursor of 299 pancreatic somatostatin, 5869 Structureof a mycobacterialpolysaccharide-fatty acyl-CoA complex: Nucleotidesequence of an invertiblecontrolling element, 4196 Nuclearmagnetic resonance studies, 2582 Nucleotidesequence of bacterialtransposon Tn1681 encodinga Nucleic acid heat-stable(ST) toxin and its identificationin enterotoxigenic see also Deoxyribonucleicacid; Hybridization, nucleic acid;Ribonucleic Escherichia coli strains, 4011 acid Nucleotide sequence of ilvGEDA operon attenuator region of Nucleic acid-specificsuppressor T cells, 1593 Escherichiacoli, 1823 Nucleocapsid Nucleotide sequence of immunoglobulin heavy chain joining segments Conformationof helical nucleocapsidsof paramyxovirusesand vesicular between translocated VH and ,u constant region genes, 3630 stomatitis virus:Reversible coiling and uncoilinginduced by changes Nucleotide sequence of influenza virus RNA segment 8 indicates that in salt concentration,2631 coding regions for NS1 and NS2 proteins overlap, 5074 Nucleolus Nucleotide sequence of Moloney leukemia virus: 3' End reveals details of Associationof ribosomalgenes in fibrillarcenter of nucleolus:A factor replication, analogy to bacterial transposons, and an unexpected gene, influencingtranslocation and nondisjunctionin humanmeiotic oocyte, 3302 6017 Nucleotide sequence of primary origin of bacteriphage T7 DNA Nucleoprotein replications: Relationship to adjacent genes and regulatory elements, Conformationof helical nucleocapsidsof paramyxovirusesand vesicular 3917 stomatitisvirus: Reversible coiling and uncoilinginduced by changes Nucleotide sequence of Salmonella typhimurium origin of DNA in salt concentration,2631 replication, 2460 Escherichiacoli RNA polymerasein vitro mimics simianvirus 40 in vivo Nucleotide sequence of thrA gene of Escherichia coli, 5730 transcriptionwhen the template is viral nucleoprotein,6556 Nucleotide sequences associated with differences in electrophoretic Nucleosome mobility of envelope glycoprotein gp70 and with Gix antigen Aggregationof small oligonucleosomalchains into 300-A globular phenotype of certain murine leukemia viruses, 1642 particles,6443 Nucleotide sequences of integrated Moloney sarcoma provirus long Compositionof native and reconstitutedchromatin particles: Direct terminal repeats and their host and viral junctions, 3937 mass determinationby scanningtransmission electron microscopy, Pentaribonucleotides of mixed sequence are synthesized and efficiently 4818 prime de novo DNA chain starts in T4 bacteriophageDNA replication Drosophilanucleosomes contain an unusualhistone-like protein, 2671 system, 5698 High-resolutionfractionation of nucleosomes:Minor particles, Pitch of chromatinDNA is reflectedin its nucleotidesequence, 3816 "whiskers,"and separationof mononucleosomescontaining and Plasmids containing insertion elements are potential transposons, 750 lackingA24 semihistone,3244 Polycistronicvesicular stomatitis virus RNA transcripts,4662 Isolationof newly replicatedchromatin by using shallowmetrizamide Posttranscriptionalmodification of mRNA conformation:Mechanism gradients,3336 that regulateserythromycin-induced resistance, 7079 Nucleosomalpackaging of thymidinekinase gene of herpes simplexvirus Predictedstructure of two adenovirustumor antigens, 3778 transferredinto mouse cells: Activelyexpressed single-copy gene, 5079 Predicting coding function from nucleotide sequence or survival of Points of contact betweenhistone H1 and histone octamer,127 "fitness" of tRNA, 3539 Stability of DNA in nucleosomes,4044 Rat calcitoninmRNA, 4444 Nucleotidesequence Rearrangementof immunoglobulinyl-chain gene and mechanismfor Bacterialplasmids containing nucleotide sequence for humanleukocyte heavy-chain class switch, 919 interferon:Construction and identification,7010 recA gene of Escherichia coli: Organization, 313 Cloningand completenucleotide sequence of human5'-a-globin gene, Regulatory region of gene for ompA protein, a major outer membrane 7054 protein of Escherichia coli, 3845 Cloningand partialnucleotide sequence of humanimmunoglobulin t Replicatorregions of yeast mitochondrialDNA responsiblefor chain cDNA from B cells and mouse-humanhybridomas, 6027 suppressiveness, 3942 Completenucleotide sequence of 23S ribosomalRNA gene from Selective amplification of variants of a complex repeating unit in DNA of Escherichiacoli, 201 a crustacean,2786 Differentpattern of codon recognitionby mammalianmitochondrial Separation'ofrandom fragments of DNA accordingto propertiesof their tRNAs, 3164 sequences, 4420 DNA sequenceencoding NH2-terminal peptide involvedin transportof X Sequence determination of protected oligodeoxyribonucleotides receptor,an Escherichiacoli secretoryprotein, 2621 containingphosphotriester linkages by californium-252plasma DNA sequenceof regulatoryregion for integrationgene of bacteriophage desorptionmass spectrometry,735 h, 2477 Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as Exons encode functionaland structuralunits of chickenlysozyme, 5759 determinedby a modificationof the dideoxynucleotidemethod, 3196 Expressionof early genes of origin-defectivemutants of simian virus 40, Sequences of recA gene and protein, 2611 3898 SpacerDNA sequencesupstream of the T-A-T-A-A-A-T-Asequence are Gene for actin in Saccharomycescerevisiae: Isolation and sequence,3912 essential for promotion of H2A histone gene transcription in vivo, 7102 Gene for iso-2-cytochromec in Saccharomycescerevisiae: Isolation and Structure of a split yeast gene: Complete nucleotide sequence of actin sequence,541 gene in Saccharomycescerevisiae, 2546 Genes for human immunoglobulinheavy chain variableregion: Structure Structure of Moloney murine leukemia viral DNA: Nucleotide sequence and multiplicity,6561 of the 5' long terminal repeat and adjacent cellular sequences, 3307 Genes for virus-associated RNAi and RNAnI of adenovirus type 2: 5'-Terminaloligonucleotide fragments of RNA transcriptssynthesized by Structure, 2424 bacteriophageT3-induced RNA polymerasefrom T3 DNA: Isolation Genetic code and codon reading patterns in Neurospora crassa and sequencedetermination, 3908 mitochondria: Novel features based on sequences of six mitochondrial Transposition of Escherichia coli insertion element ya generates a tRNAs, 3159 five-base-pairrepeat (correction),689 Genomic changes associated with antigenic variation of visna virus Nucleotidesequence, homology during persistent infection, 4454 Comparativesequence analysis of invertedterminal repetitions from Human genomic DNA encoding the pro-opiomelanocortin peptide: differentadenoviruses, 3831 Structural organization, 4890 Cyanobacterial nifH gene coding for nitrogenase reductase: Nucleotide Influenza defective interfering viral RNA is formed by internal deletion sequence, 6476 of genomic RNA, 215 DNA sequenceof baboonhighly repeatedDNA: Evolutionby nonrandom unequal crossovers, 2129 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7587

DNA sequence of Serratia marcescens lipoprotein gene, 1369 Transcription units of chicken ovalbumin genes observed after injection Integration in vivo into simian virus 40 DNA of a sequence that of cloned complete genes into Xenopus oocyte nuclei, 5984 resemblesa certainfamily of genomicinterspersed repeated sequences, Oocyte,human 4514 Associationof ribosomalgenes in fibrillarcenter of nucleolus:A factor Most sequence differences between genomes of Akv virus and a influencing translocation and nondisjunction in human meiotic oocyte, leukemogenic Gross A virus passaged in vitro are located near the 3' 6017 terminus, 4359 Oogenesis Mycoplasmas: Phylogenetic analysis, 494 Genes for chorionproteins: Amplification during oogenesis in Drosophila Nucleotide sequence divergence and functional constraint in mRNA melanogaster, 1096 evolution, 7328 Zonapellucida proteins: Synthesis by denuded and follicle-enclosed Nucleotide sequence divergence of mouse immunoglobulin yl and 72b mouse oocytes during culture in vitro, 1029 chain genes and hypothesis of intervening sequence-mediated domain Operon,L-arabinose transfer, 2143 Escherichia coli L-arabinose operon: Binding sites of regulatory proteins Sequence of picornavirus RNAs containing a radioiodinated 5'-linked and a mechanismof positive and negativeregulation, 3346 peptide reveals a conserved 5' sequence, 303 Metabolite gene regulation of L-arabinose operon in Escherichia coli Ubiquitous, interspersed repeated sequences in mammalian genomes, with indoleacetic acid and other indole derivatives, 1768 1398 Operon,histidine Unusual sequence homology at 5' ends of developmentally regulated /fA, Regulation of histidine operon of Salmonella: Model, 508 /_-, and y-globingenes of the goat, 7127 Operon,ilvGEDA Nutrient Multivalent translational control of transcription termination at Ecologicaland evolutionarysignificance of mycorrhizalsymbioses in attenuator of ilvGEDA operon of Escherichia coli K-12, 1862 vascular plants (A Review), 2113 Nucleotide sequence of ilvGEDA operon attenuator region of Serum factors modify cellular requirement for Ca2+, K+, Mg2+, Escherichia coli, 1823 phosphate ions, and 2-oxocarboxylic acids for multiplication of normal Operon,rplJL-rpoBC humanfibroblasts, 3417 Bacteriophage X vehicle for direct cloning of Escherichia coli promoter Serum factorsmodify cellularrequirement for Ca2+,K+, Mg2+, DNA sequences: Feedback regulation of rplJL-rpoBC operon, 2124 phosphate ions, and 2-oxocarboxylic acids for multiplication of normal RNA from the rplJL-rpoBC transcription unit of Escherichia coli: humanfibroblasts (correction), 6254 Attenuation and processing, 3331 Opine Oat Agropine in "null-type" crown gall tumors: Generality of the opine see Avena sativa concept, 2693 Oat coleoptile Optic nerve Vanadateinhibition of auxin-enhancedH+ secretionand elongationin Growing optic nerve fibers follow neighbors during embryogenesis, 4374 pea epicotyls and oat coleoptiles, 7242 Scrapie agent: Replication in ocular neural tissues, 1169 Oecophyllalonginoda Optic tectum Sex differencesin cooperativesilk-spinning by weaverant larvae,2343 Right and left eye bands in frogs with unilateraltectal ablations,2314 Olfaction Ornithinecarbamoyltransferase (EC 2.1.3.3) Biochemicalstudies of olfaction:Isolation, characterization, and odorant Protease apparently involved in processing of pre-ornithine bindingactivity of cilia from rainbowtrout olfactoryrosettes, 4412 transcarbamylase of rat liver: Characterization, 7044 2',5'-Oligoadenylatepolymerase Ornithinedecarboxylase (EC 4.1.1.17) (2'-5')01igo(A)polymerase activity: Elevated levels in human Activation of early enzyme production in small lymphocytes in response lymphoblastoidcells treated with glucocorticoids,6506 to high, nontlitogenic concentrations of concanavalin A, 3479 2',5'-Oligoadenylatesynthetase Calcium and microtubule dependence for increased ornithine 2',5'-Oligoadenylatesynthetase: Elongation mechanism and substrate decarboxylase activity stimulated by /-adrenergic agonists, dibutyryl specificity,4618 cyclic AMP, or serum in a rat astrocytoma cell line, 995 Regulationof stability of poly(I)-poly(C)-inducedhuman fibroblast Local anesthetics inhibit induction of ornithine decarboxylase by tumor interferonmRNA: Selective inactivationof interferonmRNA and lack promoter 12-0-tetradecanoylphorbol 13-acetate, 5312 of involvementof 2',5'-oligo(A)synthetase activation during shutoff of Ornithinedecarboxylase: Induction by renin-freenerve growthfactor, interferonproduction, 3489 4607 Oligoisoadenylatesynthetase Polyamine and differentiation: Induction of ornithine decarboxylase by Abnormalbehavior of interferon-inducedenzymatic activities in an parathyroid hormone is a good marker of differentiated chondrocytes, interferon-resistantcell line, 4479 1481 Oligonucleotidemapping Regulation of ornithine decarboxylase activity by corticotropin in Mutant and recombinantavian retroviruseswith extended host range, adrenocortical tumor cell clones: Roles of cyclic AMP and cyclic 536 AMP-dependent protein kinase, 2767 Oligosaccharide Ornithinetranscarbamylase Mannose: Transfer from GDP-mannose to lipid-linked oligosaccharide see Ornithine carbamoyltransferase by soluble mannosyl transferase, 2524 Oligosaccharide moieties of glycoprotein hormones: Bovine lutropin Immunosuppression by human plasma al-acid glycoprotein: Importance resists enzymatic deglycosylation because of terminal O-sulfated of carbohydrate moiety, 6109 N-acetylhexosamines, 7089 Osmoregulation Oligosaccharide motion in erythrocyte membranes investigated by Aminopeptidaseallele frequencydine maintainedby naturalselection, picosecond fluorescence polarization and microsecond dichroism of an 5385 optical probe, 5899 Osmoticpressure Sendai virus utilizes specific sialyloligosaccharides as host cell receptor Sickle-cell hemoglobin: Fall in osmotic pressure upon deoxygenation, determinants, 5693 4310 Oncogenesis Osteogenesisimperfecta Comparative sequence analysis of inverted terminal repetitions from Defect in structure of type I procollagen in a patient who had different adenoviruses, 3831 osteogenesis imperfecta: Excess mannose in COOH-terminal Protein encoded by transforming gene of avian sarcoma virus (pp60Src) propeptide, 6179 and a homologous protein in normal cells (pp60Pr?t-src) are associated Thermal stability of type I and type III procollagens from normal human with plasmamembrane, 3783 fibroblasts and from a patient with osteogenesis imperfecta, 162 Resistanceof simian virus 40-transformedhamster cells to cytolytic Ouabain effect of activatedmacrophages: Possible factor in species-specificviral Independence of positive inotropic effect of ouabain from inhibition of oncogenicity,6773 the heart Na+/K+ pump, 3067 Oncorhynchusgorbuscha Isolation of diploid human lymphoblast mutants presumably Calcitonin, a major gill hormone, 6935 homozygous for ouabain resistance, 1101 Oncovirus Ouabain-binding-site photoaffinity probes that label both subunits of Major structural proteins of type B, type C, and type D oncoviruses Na+,K+-ATPase, 4529 share interspecies antigenic determinants, 72 Ouabain-resistant hyperpolarization induced by insulin in aggregates of Oocyte,Xenopus laevis embryonic heart cells, 3062 Cytoplasmic clock with same period as division cycle in Xenopus eggs, Ovalbumin 462 Ovalbumin is synthesized in mouse cells transformed with natural Immunological identification and localization of predominant nuclear chicken ovalbumin gene, 244 protein of amphibian oocyte nucleus, 1034 Ovarianfollicle Le interferon mRNA from human fibroblasts, 5341 Blockadeof recruitmentof ovarianfollicles by suppressionof secondary Progesterone induces rapid increase in [Ca2+'in of Xenopus laevis surge of follicle-stimulating hormone with porcine follicular fluid, 4953 oocytes, 1534 Ovary Proteins iodinated by chloramine-T method appear to be degraded at an Similarluteinizing hormone-releasing hormone binding sites in rat abnormally rapid rate after endocytosis, 1556 anterior pituitary and ovary, 5567 Regulatory sequences in prelude sequences of an H2A histone gene Oxamate identified by study of specific deletion mutants in vivo, 1432 Active center of D- and L-lactatedehydrogenases: Studies using Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are oxamate-diaminohexyl-Sepharose affinity chromatography, 5832 essential for promotion of H2A histone gene transcription in vivo, 7102 Oxidation,biological Specific transcription factor that can bind either the 5S RNA gene or 5S Radiometric analysis of biological oxidations in man: Sex differences in RNA, 4170 .estradiol metabolism, 4957 Transcription of tRNA genes in vivo: Single-stranded compared to Oxidativephosphorylation double-stranded templates, 4147 see also Phosphorylation Downloaded by guest on September 29, 2021 7588 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Effect of uncouplers on radiosensitivity and mutagenicity in x-irradiated Subpopulationof culturedhuman promyelocytic leukemia cells (HL-60) mammaliancells, 2702 displaysthe formylpeptide chemotacticreceptor, 1000 Naphthoquinones restore active transport of solutes and oxidative Two neuroactivepeptides that cause bag cell afterdischargeand phosphorylation in irradiated membrane vesicles from Mycobacterium egg-layingin Aplysia:Purification and primarystructure, 2328 phlei, 102 Peptide map Organization of unc gene cluster of Escherichia coli coding for Aminoacid substitutionsite in a new variantof humanserum albumin, proton-translocating ATPase of oxidative phosphorylation, 7005 albuminMexico-2, 2505 Steady-state properties of coupled systems in mitochondrial oxidative Comparativetryptic peptide mappingstudies suggesta role in cell phosphorylation, 2681 transformationfor gag-relatedprotein. of avian erythroblastosisvirus Oxolinicacid and avian myelocytomatosisvirus strainsCMII and MC29,1637 DNA gyrase on the bacterial chromosome: Possibility of two levels of Highly.efficientinduction of type C retrovirusesby a humantumor in action, 6879 athymicmice, 2247 Oxygen , In vitro constructionof a B-tropicvirus by recombination:B-Tropism is Binding of 02 and CO to hemes and hemoproteins, 3171 a cryptic.phenotypeof xenotropicmurine retroviruses, 2989 Cell bioenergetics:Noninvasive, nondestructive approaches, 7430 Points of contactbetween histone HI and histone octamer,127 DeoxyhemoglobinS polymer:Determination in sickle erythrocytesupon Proteolyticallyresistant domainsof humanerythrocyte spectrin: deoxygenation, 5487 Identification,5673, Differences in Fe(II)-N,(His-F8) stretching frequencies between Synthesis of repressibleyeast acid phosphatasein vitro:Identification of deoxyhemoglobins in .the two alternative quaternary structures, 2033 multiplemRNAs and products,4504 Electron spin resonance of 170-labeled protein-peroxide radicals: Zein Peptide retentiontimes and edestin, 343 Peptide retentiontimes in high-pressureliquid chromatography Organchemiluminescence: Noninvasive assay for oxidativeradical predictedon basis of amino acid composition,1632 reactions, 347 Peptide synthesis Purificationof a manganese-containingprotein involved in see also Protein synthesis. photosynthetic oxygen evolution and its use in reconstituting an active Antibodiesspecific for carboxy-and amino-terminalregions of simian membrane, 957 virus 40 large tumorantigen, 5197 Spontaneous cancer and its possible relationship to oxygen metabolism, Cyclicenkephalin analog with high in vitro opiate activity, 7162 1763 f-Endorphinomission analogs: Dissociation of immunoreactivityfrom Superoxide dismutase: Correlation with life-span and specific metabolic other biologicalactivities, 3211 rate in primatespecies, 2777 Semisynthesisand biologicalactivity of porcine [LeuB24]insulinand Oxygenatedsterol compounds [LeuB25]insulin,3181 Humanpolymorphonuclear leukocyte chemotaxis inhibited by oxygenatedsterol compounds,4313 Pergolide:Interaction with centraldopaminergic receptors, 3725 Oxytrichafallax Perhydrohistrionicotoxin Putative actin genes in macronucleus of Oxytricha fallax, 5336 see also Histrionicotoxin Activation,inactivation, and desensitizationof acetylcholinereceptor Pacemaker channelcomplex detected by bindingof perhydrohistrionicotoxin,2309 Correlationbetween relaxation and automaticityin embryonicheart cell Peroxisome aggregates,679 Photorespirationmutants of Arabidopsisthaliana deficient in Pancreas serine-glyoxylateaminotransferase activity, 2684 see also Islets of Langerhans Petromyzonmarinus Cholecystokinin: Interaction with specific membrane receptors on Largeand persistentelectrical currents enter transectedlamprey spinal pancreatic acinar cells, 2079 cord, 1209 Distinct cholecystokininreceptors in brain and pancreas,6917 Largeand persistentelectrical currents enter transectedlamprey spinal Prostaglandinsderived from releaseof arachidonoylresidues as a result cord (correction),4390 of phosphatidylinositolbreakdown: Evidence for a role in pH stimulus-secretioncoupling, 3292 Measurementof internalpH of yeast spores by 31pnuclear magnetic Papain resonance,2470 Fluorescenceenergy transfer studies on active site of papain,940 Measurementsof pH within dormantand germinatedbacterial spores, Papilla 2474 Cell wall appositionsand plant disease resistance:Acoustic microscopy pH-dependentfusion between Semliki Forest virus membraneand of papillaethat block fungalingress, 2046 liposomes,3273 Papio papio Phagocytosis DNA sequence of baboon highly repeated DNA: Evolution by Plasminogenactivator secretion in macrophagesinduced by nonrandom unequal crossovers, 2129 electrochemicalstimulation of hexose monophosphateshunt with Silent 1-globin gene in Old Wbrld monkeys, 3563 methyleneblue, 414 Paracoccusdentrificans Receptor-mediatedendocytosis of antibody-opsonizedliposomes by Two-subunit cytochrome c oxidase (cytochrome aa3) from Paracoccus tumorcells, 4089 dentrificans,196 Phagosome Paramyxovirus Prostaglandinsynthesis by macrophagesrequires a specific Conformationof helical nucleocapsidsof paramyxovirusesand vesicular receptor-ligandinteraction, 4279 stomatitisvirus: Reversible coiling and uncoilinginduced by changes Phallacidin in salt concentration,2631 Fluorescencestaining of actin cytoskeletonin living cells with Parasite-host interaction 7-nitrobenz-2-oxa-1,3-diazole-phallacidin,980 Cell wall appositionsand plant disease resistance:Acoustic microscopy Fluorescencestaining of actin cytoskeletonin living cells with of papillaethat block fungal ingress,2046 7-nitrobenz-2-oxa-l,3-diazole-phallacidin(correction), 3747 Parathyroid Phalloidin Multipleforms of parathyroidsecretory protein-I: Synthesis, Calciumdependence of phalloidin-inducedliver cell death, 1177 intracellulardistribution, and secretion,6406 Phalloidin-inducedcholestasis: Microfilament-mediated change in Parathyroidhormone junctionalcomplex permeability, 2229 Cellularand subcellularlocalization of 1,25-(OH)2-vitaminD3 in rat Phase transition kidney:Comparison with localizationof parathyroidhormone and Body-centeredcubic phase of lipid systems:Structure, 6991 estradiol, 1149 Scanningcalorimetric evidence for a third phase transitionin Hypotensiveaction of parathyroidhormone preparations on rats and phosphatidylcholinebilayers, 5060 dogs, 675 o-Phenanthroline Multiple formsof parathyroidsecretory protein-I: Synthesis, Electrontransport: Inhibition by orthophenanthrolinein intracellulardistribution, and secretion,6406 chromatophoresand reactioncenters of Rhodopseudomonas Parathyroidhormone alters collagensynthesis and procollagenmRNA sphaeroides,1809 levels in fetal rat calvaria,5654 Phencyclidine Polyamineand differentiation:Induction of ornithinedecarboxylase by [3H]Phencyclidine:Probe for ionic channelof nicotinicreceptor,.7458 parathyroidhormone is a good markerof differentiatedchondrocytes, Phencyclidineinteractions with ionic channelof acetylcholinereceptor 1481 and electrogenicmembrane, 1224 Structureof parathyroidhormone: Theoretical study, 3791 . Structureof parathyroidhormone: Theoretical study (correction),6941 CytochromeP-450: Synthesis and insertioninto endoplasmicreticulum membranes,965 Pergolide:Interaction with centraldopaminergic receptors, 3725 Phenylalanine Parthenogen Cord-bloodtyrosine levels in full-termphenylketonuric fetus and the "Sexual"behavior in parthenogeneticlizards (Cnemidophorus),499 "justification hypothesis", 6175 Pea epicotyl 2'(3')-O-L-Phenylalanyladenosine Vanadate inhibition of auxin-enhanced H+ secretion and elongation in Hydrolysisof GTP on elongationfactor Tu-ribosome complexes pea epicotylsand oat coleoptiles,7242 promotedby 2'(3')-O-L-phenylalanyladenosine,905 Peptide Phenylketonuria see also Lipid-associatingpeptide; Protein Cord-bloodtyrosine levels in full-termphenylketonuric fetus and the DNA sequenceencoding NH2-terminal peptide involvedin transportof X "justification hypothesis", 6175 receptor, an Escherichia coli secretory protein, 2621.. Pheophytin Glucagon-relatedpeptides in rat brain:Identification and localization, Interactionbetween the intermediaryelectron acceptor (pheophytin) and 6229 a possible plastoquinone-iron complex in photosystem II reaction centers, 7227 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7589

Phorbolester Phospholipids:Translocation from inner to outer membraneof see also Phorbolmyristate acetate; 12-O-Tetradecanoylphorbol Escherichiacoli, 1867 13-acetate Release of 1-O-alkylglyceryl3-phosphorylcholine, O-deacetyl Mechanismof skin tumor promotion:Evidence for severalstages in platelet-activatingfactor, from leukocytes:Chemical ionization mass promotion,3659 spectrometryof phospholipids,7019 Phorbolesters induce differentiationin humanmalignant T Phospholipidmethylation lymphoblasts,2964 Phospholipidmethylation: A biochemicalsignal modulatinglymphocyte Phorbolester tumor promoters:Specific binding,567 mitogenesis,862 Phorbolmyristate acetate Phospholipidmethylation, Ca2+ influx, and histaminerelease: Monocyte-mediatedcytotoxicity: Oxidative mechanisms, 584 Stimulationby bridgingof IgE receptorson rat mast cells, 1903 Phorbol 12-myristate13-acetate: Selective effects on myofibrilsand Phospholipidvesicle 10-nmfilaments, 5273 see Liposome Phosphate Phosphoprotein Yeast genes with mRNA levels controlledby phosphateconcentration: see also Protein phosphorylation Isolation,6541 Structuralpolypeptides of aphthovirusare phosphoproteins,7444 Phosphatemetabolism Y73, an avian sarcomavirus: A unique transforminggene and its Rat heart analyzedin vivo by phosphorusnuclear magnetic resonance, product,a phosphopolyproteinwith protein kinase activity, 6199 299 Phosphoproteinphosphatase Phosphatidatephosphatase (EC 3.1.3.4) Double-strandedRNA inhibits a phosphoproteinphosphatase present in Acid phosphatasein pulmonarysurfactant: Properties, 808 interferon-treatedcells, 107 Phosphatidylcholine Phosphoproteinpp60rc Animalcell membranemutants altered in phosphatidylcholinesynthesis: Adhesionplaques of Rous sarcomavirus-transformed cells contain the Autoradiographicdetection, 5192 src gene product,3514 Compositionaldomain structure in phosphatidylcholine-cholesteroland Associationof the src gene productof Rous sarcomavirus with sphingomyelin-cholesterolbilayers, 4055 cytoskeletalstructures of chickenembryo fibroblasts, 3484 Saxitoxinbinding protein/Na+ gate of mammalianbrain: Molecular Differencesin intracellularlocation of pp60srcin rat and chickencells characterization,reconstitution, and "transport-specificfractionation", transformedby Rous sarcomavirus, 4142 6884 Protein encodedby transforminggene of avian sarcomavirus (pp60(rC) Scanningcalorimetric evidence for a third phase transitionin and a homologous protein in normal cells (pp60Proto-src) are associated phosphatidylcholinebilayers, 5060 with plasmamembrane, 3783 Phosphatidylcholine,dimyristoyl Phosphorylase Lecithin:cholesterolacyltransferase: Activation by a synthetic model Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: lipid- associatingpeptide, 3154 Action on proteinphosphatase(s) and its inhibitor(s),5711 Phosphatidylethanolamine Phosphorylaseb kinase Phospholipids:Translocation from inner to outer membraneof Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: Escherichiacoli, 1867 Action on protein phosphatase(s)and its inhibitor(s),5711 Phosphatidylinositol Phosphorylation Prostaglandinsderived from releaseof arachidonoylresidues as a result see also Oxidativephosphorylation; Protein phosphorylation of phosphatidylinositolbreakdown: Evidence for a role in Acetate kinase:A triple-displacementenzyme, 2626 stimulus-secretioncoupling, 3292 /-Galactoside phosphateaccumulation: Regulation in Streptococcus Phosphatidylserine pyogenes by an expulsionmechanism, 5497 Reversibilityof sodium-inducedaggregation of sonicated Halobacteria:Anaerobic growth, 3821 phosphatidylserinevesicles, 4026 Transforminggene productof Rous sarcomavirus phosphorylates Phosphocholine tyrosine,1311. Mouse immunoglobulina chain (MOPC511): Completeamino acid Photoaffinitylabeling sequence,4909 Benzodiazepinereceptor protein identified and visualizedin braintissue Phosphocreatine by photoaffinitylabel, 1666 Cell bioenergetics:Noninvasive, nondestructive approaches, 7430 Covalentlabeling of protein componentsof sodium channelwith a Phosphodiesterase photoactivablederivative of scorpiontoxin, 639 Additionalcomponent required for activity and reconstitutionof Immunoelectronmicroscopic localization of site of photo-induced light-activatedvertebrate photoreceptor GTPase, 1408 affinity labelingof small ribosomalsubunit with puromycin,890 PhosphodiesteraseI (EC 3.1.4.1) Ouabain-binding-sitephotoaffinity probes that label both subunits of Glucocorticoidhormones increase activity of plasmamembrane alkaline Na+,K+-ATPase,4529 phosphodiesteraseI in rat hepatomacells, 1005 Phosphorylationand dephosphorylationof spectrin from human 6-Phosphofructokinase(EC 2.7.1.11) erythrocyteghosts under physiologicalconditions: Autocatalysis rather Activationfactor of liver phosphofructokinase,5861 than reactionwith separatekinase and phosphatase,3264 Glucagon:Mechanism of action on hepatocytephosphofructokinase Photoaffinitylabel for /f-adrenergicreceptor: Synthesis and effects on activity, 6501 isoproterenol-stimulatedadenylate cyclase, 4449 IncreasedATP inhibitionof liver phosphofructokinasefrom genetically Photoaffinitylabeling of corticotropinreceptors, 3967 diabeticmice, 2497 Photoaffinitylabeling of rat androgen-bindingprotein, 234 Isozymesof humanphosphofructokinase: Identification and subunit Specific labelingof lac carrierprotein in membranevesicles of structuralcharacterization of a new system, 62 Escherichiacoli by a photoaffinityreagent, 6319 Permeabilizationof animalcells for kinetic studies of intracellular Specific photoaffinitylabeling inducedby energytransfer: Application to enzymes:In situ behaviorof glycolyticenzymes of erythrocytes,6324 irreversibleinhibition of acetylcholinesterase,6439 Phosphoglyceratekinase (EC 2.7.2.3) Photobacteriumfischeri Molecularabnormality of phosphoglyceratekinase-Uppsala associated Proteolyticinactivation of luciferasesfrom three species of luminous with chronicnonspherocytic hemolytic anemia, 5461 marinebacteria, Beneckea harveyi,Photobacterium fischeri, and Quantitationof mRNAs duringmouse spermatogenesis:Protamine-like Photobacteriumphosphoreum: Evidence of a conservedstructural histone and phosphoglyceratekinase-2 mRNAs increaseafter meiosis, feature,6363 6086 Photobacteriumphosphoreum PhospholipaseA2 (EC 3.1.1.4) Proteolyticinactivation of luciferasesfrom three species of luminous Mepacrineblocks f-adrenergicagonist-induced desensitization in marinebacteria, Beneckea harveyi, Photobacteriumfischeri, and astrocytomacells, 1341 Photobacteriumphosphoreum: Evidence of a conservedstructural Mitochondriaand sarcoplasmicreticulum as model targets for neurotoxic feature,6363 and myotoxicphospholipases A2, 1346 Photobleaching PhospholipaseA2 inhibitoryprotein in rabbit neutrophilsinduced by Effect of bleachinglight on measurementsof lateral diffusion in cell glucocorticoids,2533 membranesby fluorescencephotobleaching recovery method, 2043 Serum stimulationof phospholipaseA2 and prostaglandinrelease in 3T3 Lateraldistribution and diffusionof C3b receptorof complement,HLA cells is associatedwith platelet-derivedgrowth-promoting activity, 137 antigens,and lipid probesin peripheralblood leukocytes,6587 Phospholipid Photochemicallyinduced dynamic nuclear polarization Anioniclipid domains:Correlation with functionaltopography in a Photochemicallyinduced dynamic nuclear polarization investigation of mammaliancell membrane,6601 complexformation of the NH2-terminalDNA-binding domain of lac Calcium-dependentprotein kinase:Widespread occurrence in various repressorwith poly[d(AT)I,5145 tissues and phyla of animalkingdom and comparisonof effects of Photolysis ' phospholipid,calmodulin, and trifluoperazine,7039 Acetylcholinesterase:Photodestruction, 1980 Cycloheximide-inducedreversal of adrenocorticotropineffects on "Livingelectrode" as a long-livedphotoconverter for biophotolysisof steroidogenesis and adrenal phospholipids in vivo' Kinetic aspects, water,2442 7189 Oligosaccharidemotion in erythrocytemembranes investigated by Delipidation of bacteriorhodopsin and reconstitution with exogenous picosecondfluorescence polarization and microseconddichroism of an phospholipid, 323 optical probe,5899 Delipidation of bacteriorhodopsin and reconstitution with exogenous Time-resolved studies of ATP-requiring biological systems: Laser flash phopholipid (correction), 2353 photolysisof caged ATP, 7237 Diphtheria toxin: Binding to phospholipids in liposomes, 1986 Photorespiration Enhancement of phospholipid transfer from Sendai virus to erythrocytes Photorespirationmutants of Arabidopsisthaliana deficient in is mediated by target cell membrane, 804 serine-glyoxylate aminotransferase activity, 2684 Phospholipidmethylation during chemotaxis in Dictyostelium Photosensitiveprobe discoideum:Regulation by guanosine3',5'-cyclic monophosphate, 6996 Photoaffinitylabeling of rat androgen-bindingprotein, 234 Phospholipidsas molecularinstruments of ion and solute transportin biologicalmembranes, 257 Downloaded by guest on September 29, 2021 7590 Biological Sciences Subject Index Proc. 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Photosynthesis Sequentialaddition of platelet factorand plasmato BALB/c 3T3 Chloroplast phosphoproteins: Regulation of excitation energy transfer by fibroblastcultures stimulates somatomedin-C binding early in cell phosphorylation of thylakoid membrane polypeptides, 5253 cycle, 6644 Contrasts between oxygenic and anoxygenic photoreduction of Sex steroid-bindingprotein of plasma:Immunocytochemical localization ferredoxin: Incompatibilities with prevailing concepts of in tissues of adult monkey Macaca nemestrina, 5678 photosynthetic electron transport, 2676 Plasmacytoma Cyanobacterial phycobilisomes: Selective dissociation monitored by Transcription of mouse Kchain genes: Implications for allelic exclusion, fluorescence and circular dichroism, 1961 1937 Electron transport: Inhibition by orthophenanthroline in Plasmid chromatophores and reaction centers of Rhodopseudomonas see also Deoxyribonucleic acid, plasmid sphaeroides, 1809 Agropine in "null-type" crown gall tumors: Generality of the opine Energy transfer between photosystem II units in a connected package concept, 2693 model of the photochemical apparatus of photosynthesis, 4697 Association of 2-,m DNA plasmid with yeast folded chromosomes, 3144 Flash-activated cyclic electron transport system constructed by using Bacterial plasmids containing nucleotide sequence for human leukocyte bacterial reaction centers and ubiquinone-cytochrome b-cl/c segment interferon: Construction and identification, 7010 of mitochondria, 6339 Broad host range DNA cloning system for Gram-negative bacteria: Interaction between the intermediary electron acceptor (pheophytin) and Construction of a gene bank of Rhizobium meliloti, 7347 a possible plastoquinone-iron complex in photosystem II reaction Change in rate of transcription of a eukaryotic gene in response to cyclic centers, 7227 AMP, 7171 Magnetic field-induced increase in chlorophyll a delayed fluorescence of Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences photosystem II: A 100- to 200-ns component between 4.2 and 300 K, as BamHI fragments, 4201 5889 Copy-number mutants of plasmid carrying replication origin of Photorespiration mutants of Arabidopsis thaliana deficient in Escherichia coli chromosome: Evidence for a control region of serine-glyoxylate aminotransferase activity, 2684 replication, 3993 Pigment-protein complexes of Rhodopseudomonas sphaeroides: Cotransfer of circular and linear prokaryotic and eukaryotic DNA Isolation and characterization by lithium dodecyl sequences into mouse cells, 4852 sulfate/polyacrylamide gel electrophoresis, 87 Cytokinin production, presence of plasmids, and fasciation caused by Purification of a manganese-containing protein involved in strains of Corynebacterium fascians, 619 photosynthetic oxygen evolution and its use in reconstituting an active DNA-membrane association is necessary for initiation of chromosomal membrane, 957 and plasmid replication in Bacillus subtilis, 2834 Stoichiometry of system I and system II reaction centers and of DNA strand initiation sequence of ColEl plasmid: Expression in a plastoquinone in different photosynthetic membranes, 4712 single-stranded DNA phage, 6566 Supramolecular structure of stacked and unstacked regions of Drosophila DNA-binding protein DB-2: Demonstration of its photosynthetic membranes of Prochloron sp., a prokaryote, 352 sequence-specific interaction with DNA, 3773 Triplet states in photosystem I of spinach chloroplasts and Extrachromosomal genetic elements: Preferential inclusion in yeast subchloroplast particles (correction), 1229 meiotic spores, 5380 Phycobiliprotein Formation of a RNA primer for initiation of replication of ColEl DNA Cyanobacterial phycobilisomes: Selective dissociation monitored by by H, 2450 fluorescence and circular dichroism, 1961 Human fibroblast interferon gene: Expression in Escherichia coli, 5230 Phycobilosome Initiation of DNA replication in a ColEl-type plasmid: Isolation of Cyanobacterial phycobilisomes: Selective dissociation monitored by mutations in ori region, 6744 fluorescence and circular dichroism, 1961 Mu-containing plasmids: Association with Escherichia coli chromosome Phytochrome upon prophage induction, 1778 cis-4-Cyclohexene-1,2-dicarboximide: Inhibitor of Nucleotide sequence of influenza virus RNA segment 8 indicates that phytochrome-promoted seed germination, 3408 coding regions for NS1 and NS2 proteins overlap, 5074 Phytohemagglutinin Plasmid ColEl: Sequence-specific recombination, 6724 Human T-cell growth factor from phytohemagglutinin-stimulated Plasmid-dependent temperature-sensitive phase in crown gall lymphocyte-conditioned media: Purification and some characteristics, tumorigenesis, 2688 61.34 Plasmid pBR322: Replication under control of a cloned replication origin Inhibition of Ca2+ accumulation in mitogen-activated lymphocytes: Role from single-strandedDNA phage M13, 4638 of membrane-bound plasma lipoproteins, 4764 Posttranscriptional regulation of an erythromycin resistance protein Pichia pastoris specified by plasmid pE194, 3903 Measurement of internal pH of yeast spores by 31P nuclear magnetic Proteins encoded by Agrobacterium tumefaciens Ti plasmid DNA resonance, 2470 (T-DNA) in crown gall tumors, 2666 Pigeon Recombination between higher plant DNA and Ti plasmid of Resurgence of responding after cessation of response-independent Agrobacterium tumefaciens, 6448 reinforcement, 6251 Recombination genes on Escherichia coli sex factor specific for Pigment-protein complex transposable elements, 2814 Pigment-protein complexes of Rhodopseudomonas sphaeroides: Replication of plasmids from Staphylococcus aureus in Escherichia coli, Isolation and characterization by lithium dodecyl 7333 sulfate/polyacrylamide gel electrophoresis, 87 "Superkiller" mutations suppress chromosomal mutations affecting Pineal gland double-stranded RNA killer plasmid replication in Saccharomyces Circadian rhythms of melatonin release from individual superfused cerevisiae, 527 chicken pineal glands in vitro, 2319 Targeted deletions of sequences from closed circular DNA, 2455 Pteridines as nonretinal regulators of light-dependent melatonin T-DNA from Agrobacterium Ti plasmid is in the nuclear DNA fraction biosynthesis, 2415 of crown gall tumor cells, 4060 Pinocytosis Tetracycline: Active efflux encoded by four genetically different Kinetics of membraneinternalization and recyclingduring pinocytosis in tetracycline resistance determinants in Escherichia coli, 3974 Dictyostelium discoideum, 1015 Transposon Tn901 introduced into a plasmid of Anacystis nidulans: Pituitary Preparation for cloning in cyanobacteria, 1570 see also Cell, pituitary Two Escherichia coli factor Y effector sites identified near origins of Adrenocortical response to corticotropin is potentiated by part of replication of plasmids ColEl and pBR322, 6521 amino-terminal region of pro-corticotropin/endorphin, 2239 Plasmid,recombinant Immunoreactive dynorphin in pituitary and brain, 6207 Cloning DNA sequences from influenza viral RNA segments, 210 y-Lipotropin from human pituitary glands: Isolation and amino acid Cloning of an origin of DNA replication of Xenopus laevis, 5292 sequence, 7214 Cloning of sea urchin actin gene sequences for use in studying regulation Opiate regulation of estradiol-2-hydroxylase in brains of male rats: of actin gene transcription, 765 Mechanism for control of pituitary hormone secretion, 2574 Deletions covering putative promoter region of early mRNAs of simian [Phe4]Somatostatin: Potent, selective inhibitor of growth hormone virus 40 do not abolish T-antigen expression, 3865 release, 577 Direct transfer of cloned genes from bacteria to mammalian cells, 2163 Similar luteinizing hormone-releasing hormone binding sites in rat DNA replication in vitro of recombinant plasmid DNAs containing the anterior pituitary and ovary, 5567 origin of progeny replicative form DNA synthesis of phage XX174, Placenta 5182 Placental alkalinephosphatase in nonmalignanthuman cervix, 4226 Genetic transformation of mouse embryos by microinjection of purified Plant disease DNA, 7380 Cell wall appositionsand plant disease resistance:Acoustic microscopy Isolation of getes by complementation in yeast: Molecular cloning of a of papillaethat block fungal ingress,2046 cell-cycle gene, 2119 Plant growth Molecular cloning of human interferon cDNA, 4003 Mammalian epidermal growth factor promotes plant growth, 4836 Nucleotide sequence of a cDNA clone derived from common region of Plasma avian sarcoma virus messenger RNA: Unusual features, 176 see also Serum Plasmids containing insertion elements are potential transposons, 750 Cardioactive factor in human plasma with positive inotropic and positive Recombinant plasmids constructed containing rat muscle actin and chronotropic activity, 6820 myosin light chain DNA sequences, 960 Cholesteryl ester transfer complex in human plasma, 3327 Simian virus 40 origins defective in tumor antigen binding and DNA Do plasma and serum have different abilities to promote cell growth? replication: Construction and analysis, 6491 2726 Thymidine kinase and human globin genes microinjected into mouse Inhibition of receptor-mediated clearance of lysine and fibroblasts: Replication and expression, 5399 arginine-modified lipoproteins from plasma of rats and monkeys, 225 Transformation of rat embryo fibroblasts by cloned polyoma virus DNA fragments containing only part of the early region, 3978 Downloaded by guest on September 29, 2021 Proc. 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Plasmin Enzymenull alleles in naturalpopulations of Drosophilamelanogaster: Protease-activated"prodrugs" for cancerchemotherapy, 2224 Frequenciesin a North Carolinapopulation, 1091 Sensitive assay for plasminogen activator of transformed cells, 3796 Geneticvariability and effective populationsize when local extinction Plasminogen and recolonizationof subpopulationsare frequent,6710 Plasminogen: Production and release by isolated perfused rat liver, 6837 Highly polymorphic locus in human DNA, 6754 Plasminogenactivator Inherited structural polymorphism of the fourth component of human Embryonal carcinoma cell line Fg: Growth and differentiation in defined complement,3576 media, 457 Metabolic resource allocation vs. mating attractiveness: Adaptive Plasminogen activator of islets of Langerhans: Modulation by glucose pressures on the "alba" polymorphism of Colias butterflies, 3615 and correlationwith insulin production,875 Polymorphism in mitochondrial DNA of humans as revealed by Plasminogen activator secretion in macrophages induced by restriction endonuclease analysis, 3605 electrochemical stimulation of hexose monophosphate shunt with Polymorphism of human B-cell alloantigens: Evidence for three loci methylene blue, 414 within the HLA system, 6101 Protease-activated "prodrugs" for cancer chemotherapy, 2224 Prenataldiagnosis of sickle cell anemiaby restrictionendonuclease Sensitive assay for plasminogen activator of transformed cells, 3796 analysis: HindIII polymorphisms in 'y-globin genes extend test Plasmodiumfalciparum applicability,2853 Stage-specific proteins and glycoproteins of Plasmodium falciparum: Quantitativegenetic variationof enzyme activities in naturalpopulations Identification of antigens unique to schizonts and merozoites, 3695 of Drosophilamelanogaster, 1073 Plasmodiumgallinaceum Selection for viabilityat loci controllingprotein polymorphismsin Anti-gamete monoclonal antibodies synergistically block transmission of Drosophila melanogaster is very weak at most, 4857 malaria by preventing fertilization in mosquito, 6797 Triplicateda-globin loci in humans,518 Plastoquinone PolymyxinB Interaction between the intermediary electron acceptor (pheophytin) and Anioniclipid domains:Correlation with functionaltopography in a a possible plastoquinone-iron complex in photosystem II reaction mammaliancell membrane,6601 centers, 7227 Polyomavirus Stoichiometry of system I and system II reaction centers and of Amplificationof integratedviral DNA sequencesin polyoma plastoquinone in different photosynthetic membranes, 4712 virus-transformedcells, 3850 Platelet Codingcapacity of a 35%fragment of polyomavirus genomeis sufficient Agonist versus antagonist binding to a-adrenergic receptors, 4569 to initiate and maintaincellular transformation, 3278 Arachidonate metabolism via lipoxygenase and Polyomalarge tumor antigen is not requiredfor tumorigenesismediated 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to by viral DNA, 1336 anti-inflammatory drugs, 308 Polyomavirus mutants able to develop in embryonalcarcinoma cells: Dissociationof vasoconstrictorand platelet aggregatoryactivities of Isolationand characterization,1068 thromboxane by carbocyclic thromboxane A2, a stable analog of Simian virus 40 and polyomavirus stimulate overallcellular RNA and thromboxane A2, 1706 proteinsynthesis, 1476 Factor VIII antigen in von Willebrand disease: Structural analysis, 6832 Transformationof rat embryofibroblasts by cloned polyomavirus DNA Human platelet basic protein associated with antiheparin and mitogenic fragmentscontaining only part of the early region,3978 activities: Purification and partial characterization, 5914 Polyphasiclinkage Malondialdehyde alteration of low density lipoproteins leads to Ligand-linkedphase changesin a biologicalsystem: Applications to cholesteryl ester accumulation in human monocyte-macrophages, 2214 sickle cell hemoglobin, 5239 Maternal inheritance of human mitochondrial DNA, 6715 Polyphosphate Persistence of increased platelet cyclic AMP induced by prostaglandin Membraneprotein lateral mobility:Modulation by polyphosphatesand E1 after removal of the hormone, 2946 polyamines,1457 Sequential addition of platelet factor and plasma to BALB/c 3T3 Polyribonucleotidesynthetase (ATP) (EC 6.5.1.3) fibroblast cultures stimulates somatomedin-C binding early in cell RNA primerused in synthesis of anticomplementaryDNA by reverse cycle, 6644 transcriptaseof avian myeloblastosisvirus, 1316 Thrombin increases expression of fibronectin antigen on platelet surface, Polysaccharide,capsular 1049 Immunochemicaldetermination of configurationof a haptenic Platelet-activating factor substituent,4244 Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl Polysaccharide-fattyacyl-CoA platelet-activating factor, from leukocytes: Chemical ionization mass Structureof a mycobacterialpolysaccharide-fatty acyl-CoA complex: spectrometry of phospholipids, 7019 Nuclearmagnetic resonance studies, 2582 Platelet-aggregating material Poly(LTyr,LGlu)-poly(DLAla)--poly(LLys) Correlation between spontaneous metastatic potential, Geneticallycontrolled formation of antibodyto a synthetic antigen platelet-aggregatingactivity of cell surfaceextracts, and cell surface [poly(LTyr,LGlu)-poly(DLAla)--poly(LLys)] covalently bound to a sialylationin 10 metastatic-variantderivatives of a rat renal sarcoma synthetic adjuvant(N-acetylmuramyl-L-alanyl-D-isoglutamine), 4933 cell line, 4336 Population,density-regulated Poliovirus Species near its equilibriumsize in a fluctuatingenvironment can evolve Purification of a factor that restores translation of vesicular stomatitis a lower intrinsicrate of increase,7497 virus mRNA in extracts from poliovirus-infected HeLa cells, 770 Populationdynamics Sequence of picornavirus RNAs containing a radioiodinated 5'-linked Density-dependentselection in a randomenvironment: An evolutionary peptide reveals a conserved 5' sequence, 303 processthat can maintainstable populationdynamics, 7501 Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as Populationoscillation determined by a modification of the dideoxynucleotide method, 3196 Populationoscillations and energyreserves in planktoniccladocera and Poly(adenosine diphosphate ribose) their consequencesto competition,1716 Poly(ADP-ribose) synthesis, a marker of granulocyte differentiation, Porphyria 3682 Rare structuralvariants of humanand murineuroporphyrinogen I Polyadenylate synthase, 2848 Could poly(A) align splicing sites of messenger RNA precursors? 1278 Potassium Repeating structure of cytoplasmic poly(A)-ribonucleoprotein, 1890 Correlationbetween relaxation and automaticityin embryonicheart cell Polyamine aggregates,679 see also specific polyamines Kinetic models suggest bimolecularreaction steps in axonal Na+-channel Local anesthetics inhibit induction of ornithine decarboxylase by tumor gating,6582 promoter 12-O-tetradecanoylphorbol 13-acetate, 5312 Membraneelectrical excitability in Drosophila:Facilitation, 6216 Membrane protein lateral mobility: Modulation by polyphosphates and Nigericin-stimulatedATPase activity in microsomalvesicles of tobacco polyamines, 1457 callus, 5904 Naturally occurring anti-spermine antibody in normal rabbit serum, 2904 Sodium and potassiumsalt stimulationof taste receptorcells: Allosteric Polyamine and differentiation: Induction of ornithine decarboxylase by model, 1686 parathyroid hormone is a good marker of differentiated chondrocytes, Potato spindle tuber viroid 1481 Potato spindle tuber viroid cDNA sequences:Molecular cloning and Polyethylene glycol characterization,5302 Alternative method for identifying reconstituted cells, 381 Preadipocyte Protection of cultured renal tubular epithelial cells from anoxic cell Insulin receptorsynthesis and turnoverin differentiating3T3-L1 swelling and cell death, 5445 preadipocytes,285 Polylactosaminoglycan Pyruvatecarboxylase apoenzyme and holoenzyme:Induction in 3T3-L1 Membranedifferentiation in humanerythroid cells: Unique profilesof cells duringdifferentiation, 1321 cell surface glycoproteins expressed in erythroblasts in vitro from Pregnancy three ontogenic stages, 3474 Proportionof fetal hemoglobinsynthesis decreasesduring erythroid cell Polymorphism maturation,2757 see also Isozyme Preproinsulin Albumin Naskapi variant in North American Indians and Eti Turks, Bacteriamature preproinsulin to proinsulin,3988 5480 Eukaryoticsignal sequencetransports insulin antigen in Escherichia Amino acid substitution site in a new variant of human , coli, 3369 albumin Mexico-2, 2505 Preproparathyrin Aminopeptidase allele frequency dine maintained by natural selection, Synthetic precursor-specificregion of preproparathyroidhormone: 5385 Conformationalstudies, 3983 Diffusion model for genotype-dependent migration, 4842 Preprosomatostatin Drosophilaalcohol dehydrogenase gene: Isolationand partial Biosynthesisin vitro of fish islet preprosomatostatin:Processing and characterization,5794 segregationof a high molecularweight precursor,4074 Downloaded by guest on September 29, 2021 7592 Biological Sciences Subject Index Proc. 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Nucleotide sequence of a cloned structural gene coding for a precursor of Regulation of cyclic AMP formation in brain tissue by a-adrenergic pancreatic somatostatin, 5869 receptors: Requisite intermediacy of prostaglandins of the E series, Primatespecies 3024 Superoxidedismutase: Correlation with life-span and specific metabolic Prostaglandinsynthetase rate in primatespecies, 2777 see Prostaglandin synthase Prochloron Prostate Supramolecularstructure of stackedand unstackedregions of Sex steroid-binding protein of plasma: Immunocytochemical localization photosynthetic membranes of Prochloron sp., a prokaryote, 352 in tissues of adult monkey Macaca nemestrina, 5678 Procollagen Protease A,B procollagen:Biosynthesis, 6434 see also Serine protease Defect in structureof type I procollagenin a patient who had Neutral protease activation of peritoneal macrophage prostaglandin osteogenesis imperfecta: Excess mannose in COOH-terminal synthesis, 4736 propeptide,6179 Protease apparently involved in processing of pre-ornithine Structuralbasis for apparentheterogeneity of collagensin human transcarbamylase of rat liver: Characterization, 7044 basement membranes: Type IV procollagen contains two distinct Regulation of hippocampal glutamate receptors: Involvement of a chains, 745 calcium-activated protease, 2298 Thermalstability of type I and type III procollagensfrom normalhuman Protein fibroblasts and from a patient with osteogenesis imperfecta, 162 see also Glycoprotein; Guanine nucleotide regulatory protein; Peptide; Pro-corticotropin/endorphin Phycobiliprotein; Transport, protein; Tuberculoprotein Adrenocortical response to corticotropin is potentiated by part of Protein, allosteric amino-terminal region of pro-corticotropin/endorphin, 2239 Communication between catalytic subunits in hybrid aspartate Prodrug transcarbamoylase molecules: Effect of ligand binding to active chains Protease-activated "prodrugs" for cancer chemotherapy, 2224 on conformation of unliganded, inactive chains, 5187 Proflavine Differences in Fe(II)-N,(His-F8) stretching frequencies between X-ray structure of a cytidylyl-3',5'-adenosine-proflavine complex: A deoxyhemoglobins in the two alternative quaternary structures, 2033 self-paired parallel-chain double helical dimer with an intercalated Interchain disulfide bond: Effect on hapten binding properties of light acridine dye, 1852 chain dimer of protein 315 (correction), 1229 Progesterone Propagation of conformational changes in Ni(II)-substituted aspartate Deoxycorticosterone biosynthesis in human kidney: Potential for transcarbamoylase: Effect of active-site ligands on regulatory chains, formation of a potent mineralocorticosteroid in its site of action, 7069 1995 Progesterone induces rapid increase in [Ca2+]inof Xenopus laevis Sequential folding of a bifunctional allosteric protein, 3379 oocytes, 1534 Protein, androgen-binding Progesterone inhibition of uterine nuclear estrogen receptor: Dependence Androgen-binding protein: Localization in proliferating Sertoli cells in on RNA and protein synthesis, 5856 culture, 5322 Prolactin Photoaffinity labeling of rat androgen-binding protein, 234 see also Gene, prolactin Proteinaseinhibitor Absolute requirement of glucocorticoid for expression of the casein gene In vitro synthesis of pre-proteins of vacuolar compartmented proteinase in presence of prolactin, 6003 inhibitors that accumulate in leaves of wounded tomato plants, 1975 Epidermal growth factor and expression of specific genes: Effects on Protein, basic cultured rat pituitary cells are dissociable from mitogenic response, Structurally unique basic protein coextracted with histones from calf 394 thymus chromatin, 1389 Prostaglandin I2 modifies both prolactin binding capacity and fluidity of Protein, Bence Jones mouse liver membranes, 6597 Self-association of human immunoglobulin KIlight chains: Role of the Stress-induced release of prolactin: Blockade by dexamethasone and third hypervariable region, 1144 naloxone may indicate f-endorphin mediation, 666 Protein body Proline Protein bodies of mung bean cotyledons as autophagic organelles, 428 Proline cis-trans isomerization involved in the slow unfolding reaction of Protein, bone RNase A, 795 Radioimmunoassay for vitamin K-dependent protein of bone and its Pyrroline-5-carboxylate synthase activity in mammalian cells, 5221 discovery in plasma, 2234 Promoter Protein, cap-binding Novel RNA polymerase a factor from Bacillus subtilis, 7000 Purificationof a factorthat restorestranslation of vesicularstomatitis Rate-limiting steps in RNA chain initiation, 5634 virus mRNA in extracts from poliovirus-infected HeLa cells, 770 Transcription in vitro of normal, mutant, and truncated mouse a- globin Protein, capsid genes, 7132 Capsidprotein of Semliki Forest virus has clustersof basic amino acids Pro-opiomelanocortin and prolinesin its amino-terminalregion, 6376 Humangenomic DNA encodingthe pro-opiomelanocortinpeptide: Protein, carbohydrate-binding Structuralorganization, 4890 The cbpA gene: Role of the 26,000-dalton carbohydrate-binding protein in intercellular cohesion of developing Dictyostelium discoideum cells, Antibody-independentactivation of alternativecomplement pathway by 4788 measlesvirus-infected cells, 559 Protein, lac carrier Specific labeling of lac carrier protein in membrane vesicles of P-Adrenergicreceptor in frog erythrocytemembranes: Cytoskeletal Escherichia coli by a photoaffinity reagent, 6319 constraint,6401 Protein, cataboliteactivator Prosomatostatin Metabolite gene regulation of L-arabinose operon in Escherichia coli Isolationand structureof pro-somatostatin:A putative somatostatin with indoleaceticacid and other indole derivatives,1768 precursorfrom pig hypothalamus,4489 Protein, cell surface Prosomatostatin:Identification in pancreaticislets, 2410 Cell surfaceprotein, p97, identifiedin humanmelanomas and certain Prosomatostatin:Synthesis and biologicalactions, 6171 other neoplasms, 2183 Prostacyclin,10,10-difluoro-13,14-dehydro- Protein, chorion 10,10-Difluoro-13,14-dehydroprostacyclin:Vascular relaxing activity and Genes for chorion proteins: Amplification during oogenesis in Drosophila stability studies, 6846 melanogaster, 1096 Prostaglandin Untranslated mRNA for a chorion protein of Drosophila melanogaster Desensitizationof enucleatedcells to hormonesand role of cytoskeleton accumulatestransiently at onset of specificgene amplification,5789 in controlof normalhormonal response, 4798 Protein cII/cIII 10,10-Difluoro-13,14-dehydroprostacyclin:Vascular relaxing activity and DNA sequenceof regulatoryregion for integrationgene of bacteriophage stability studies, 6846 X, 2477 Generalmethod, employing arsenazo III in liposomes,for study of Site-specific recombination functions of bacteriophage X: DNA sequence calciumionophores: Results with A23187and prostaglandins,1506 of regulatoryregions and overlappingstructural genes for Int and Xis, Neutral proteaseactivation of peritonealmacrophage prostaglandin 2482 synthesis,4736 Protein, coat Persistenceof increasedplatelet cyclic AMP inducedby prostaglandin Mechanisms of membrane assembly: Effects of energy poisons on E1 after removalof the hormone,2946 conversion of soluble M13 coliphage procoat to membrane-bound coat Prostaglandin I2 modifies both prolactin binding capacity and fluidity of protein,827 mouse liver membranes, 6597 Procoat, the precursor of M13 coat protein, requires an electrochemical Prostaglandins derived from release of arachidonoyl residues as a result potential for membraneinsertion, 4669 of phosphatidylinositol breakdown: Evidence for a role in Protein crystallography stimulus-secretion coupling, 3292 see also X-ray crystallography Prostaglandin synthesis by macrophages requires a specific Electronparamagnetic resonance spectroscopy of Cu2+in hen egg-white receptor-ligand interaction, 4279 lysozyme, 5243 Regulation of cyclic AMP formation in brain tissue by a-adrenergic Potato inhibitor complex of carboxypeptidase A: Structure at 5.5-A receptors: Requisite intermediacy of prostaglandins of the E series, resolution, 277 3024 Protein degradation Serum stimulation of phospholipase A2 and prostaglandin release in 3T3 ATP-dependentconjugation of reticulocyteproteins with polypeptide cells is associated with platelet-derived growth-promoting activity, 137 required for protein degradation, 1365 Prostaglandin synthase (EC 1.14.99.1) Carbohydraterequirement for expressionand stability of acetylcholine Establishment of interferon-mediated antiviral state: Role of fatty acid receptor on surface of embryonic muscle cells in culture, 5263 cyclooxygenase, 5437 Degradation process: Role in mitogenic effect of epidermal growth factor, 1466 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7593

Proposed role of ATP in protein breakdown: Conjugation of proteins Dopamineand depolarizingagents regulatestate of phosphorylationof with multiple chains of polypeptide of ATP-dependent proteolysis,' protein I in mammalian superior cervical sympathetic ganglion, 7479 1783 Double-stranded RNA-activated eukaryotic initiation factor 2 kinase Proteins iodinated by chloramine-T method appear to be degraded at an from rabbitreticulocytes: Purification and properties,6526 abnormally rapid rate after endocytosis, 1556 Double-stranded-RNA-activated kinase that phosphorylates a subunit of Protein, deoxyribonucleicacid-binding eukaryotic initiation factor 2 (eIF-2a) in reticulocyte lysates, 832 see also Protein, gene 32 Double-stranded RNA inhibits a phosphoprotein phosphatase present in Amino acid sequence of the T4 DNA helix-destabilizing protein, 4614 interferon-treated cells, 107 Chemical carcinogen-modified DNA recognized by a DNA-binding Microtubule-associated protein 2 (MAP2): Structure and protein, 3201 phosphorylation, 3206 Chemical carcinogen-modified DNA recognized by a DNA-binding Protein encoded by transforming gene of avian sarcoma virus (pp60src) protein (correction), 7510 and a homologous protein in normal cells (pp60Proto-src)are associated Drosophila DNA-binding protein DB-2: Demonstration of its with plasma membrane, 3783 sequence-specific interaction with DNA, 3773 Transforming gene product of Rous sarcoma virus phosphorylates recA protein-catalyzed strand assimilation: Stimulation by Escherichia tyrosine, 1311 coli single-stranded DNA-binding protein, 857 Tyrosine hydroxylase: Substrate of cyclic AMP-dependent protein Switches in macromolecular synthesis during induction of competence kinase, 92 for transformation of Streptococcus sanguis, 6062 Y73, an avian sarcoma virus: A unique transforming gene and its Protein diffusion product, a phosphopolyprotein with protein kinase activity, 6199 Effect of bleaching light on measurements of lateral diffusion in cell Protein kinase (EC 2.7.1.37) membranes by fluorescence photobleaching recovery method, 2043 A "mute" catalytic subunit of cyclic AMP-dependent protein kinase Protein, dnaG from rat muscle and its mode of activation, 2492 Initiation of DNA replication by Escherichia coli dnaG protein: Cyclic GMP-dependent protein kinase and substrate: Localization in Evidence that tertiary structure is involved, 900 mammalian cerebellum, 5537 Protein, folate-binding Differential expression of type I and type II cyclic AMP-dependent Folate binding protein of mitochondria identified as dimethylglycine protein kinases during cell cycle and cyclic AMP-induced growth dehydrogenase, 4484 arrest, 3445 Inhibiting the onset of hormone-induced desensitization of viable see also Protein structure thymocytes by NA-tosyl-L-lysine chloromethyl ketone, 5967 Altered enolase in aged Turbatrix aceti results from conformational Intracellularinjection of catalytic subunit of cyclic AMP-dependent changes in the enzyme, 5865 protein kinase simulates facilitation of transmitter release underlying Hydrophobic basis of packing in globular proteins, 4643 behavioral sensitization in Aplysia, 7492 Path of the polypeptide in bacteriorhodopsin, 2023 Regulation of ornithine decarboxylase activity by corticotropin in Proline cis-trans isomerization involved in the slow unfolding reaction of adrenocortical tumor cell clones: Roles of cyclic AMP and cyclic RNase A, 795 AMP-dependent protein kinase, 2767 Rate enhancement of reconstitution of glyceraldehyde-3-phosphate Transformation-defective mutant of Abelson murine leukemia virus dehydrogenase by a covalently bound coenzyme analog, 1966 lacks protein kinase activity, 4993 Sequential folding of a bifunctional allosteric protein, 3379 Protein, lamB Three-dimensional structure of the "long" neurotoxin from cobra venom, Specificity of diffusion channels produced by X phage receptor protein of 2400 Escherichia coli, 167 Protein, G Protein, leucine-specificbinding Coated vesicles transport newly synthesized membrane glycoproteins Amino-terminal sequence and processing of precursor of leucine-specific from endoplasmic reticulum to plasma membrane in two successive binding protein, and evidence for conformational differences between stages, 780 precursor and mature form, 2005 Protein, gag-related Protein, lexA Comparative tryptic peptide mapping studies suggest a role in cell Escherichia coli lexA protein: Cleavage by the recA protease, 3225 transformation for gag-related protein of avian erythroblastosis virus Protein, macrophage-and granulocyte-inducing and avian myelocytomatosis virus strains CMII and MC29, 1637 Desensitizationof enucleatedcells to hormonesand role of cytoskeleton Protein, gene 32 in controlof normalhormonal response, 4798 see also Protein, deoxyribonucleic acid-binding Protein, membrane Homologous pairing in genetic recombination: Formation of D loops by see Membrane protein combined action of recA protein and a helix-destabilizing protein, 2606 Protein, methyl-acceptingchemotaxis L factor required for /-galactosidase synthesis is the nusA gene product Receptorstructure in bacterialsensing system, 7157 involved in transcription termination, 1991 Protein methylation Protein, gene 41 Multiple methylation in processing of sensory signals during bacterial Pentaribonucleotidesof mixed sequenceare synthesizedand efficiently chemotaxis, 2429 prime de novo DNA chain starts in T4 bacteriophage DNA replication Structural studies of methyl-accepting chemotaxis proteins of system, 5698 Escherichia coli: Multiple methylation sites, 2434 Protein, gene 61 Protein-methylglyoxal Pentaribonucleotidesof mixed sequenceare synthesizedand efficiently Protein-methylglyoxaladduct: Spectroscopic studies, 949 prime de novo DNA chain starts in T4 bacteriophage DNA replication Protein, microtubule-associated system, 5698 High molecularweight polypeptides(270,000-340,000) from cultured Protein, globular cells are related to hog brain microtubule-associated proteins but Hydrophobic basis of packing in globular proteins, 4643 copurify with intermediate filaments, 4808 Protein, heat-shock-induced Microtubule-associated protein 2 (MAP2): Structure and Four heat shock proteins of Drosophila melanogaster coded within a phosphorylation, 3206 12-kilobase region in chromosome subdivision 67B, 5390 Microtubule-associated proteins: A monoclonal antibody to MAP2 binds Genes for three Drosophila heat-shock-induced proteins at a single locus, to differentiated neurons, 4741 2134 Protein, muscle Protein, helix-destabilizing Identification of an N2 line protein of striated muscle, 3254 Immunoreactivehelix-destabilizing protein localized in transcriptionally Protein, nonhistone active regions of Drosophila polytene chromosomes, 6749 talpid2 mutant of the chickenwith perturbedcartilage development has Protein, high-mobility group an altered precartilage-specificchromatin protein, 4828 Deoxyribonuclease I-sensitive structure reconstituted on active genes, Protein, nuclear 1787 Host nuclearproteins expressed in simian virus 40-transformedand Protein, histone-like -infectedcells, 97 Drosophila nucleosomes contain an unusual histone-like protein, 2671 Immunologicalidentification and localizationof predominantnuclear Novel histone H2A-like protein of Escherichia coli, 5097 protein of amphibianoocyte nucleus, 1034 Prokaryotic histone-like protein interacting with RNA polymerase, 3548 Protein, ompA Protein, human milk Primarystructure of majorouter membraneprotein II* (ompAprotein) Human protein related to major envelope protein of murine mammary of Escherichia coli K-12, 4592' tumor virus: Identification and characterization, 1301 Protein p3 C Protein, 256I-labeled Protein p3 is linked to DNA of phage 029 througha phosphoesterbond Proteins iodinated by chloramine-T method appear to be degraded at an betweenserine and 5'-dAMP,6425 abnormally rapid rate after endocytosis, 1556 Protein, penicillin-binding Protein, iron-sulfur Cellular division in Escherichia coli: Isolation and characterization of Iron proteinsfrom the nitrogenfixation complexesof Azotobacter penicillin-bindingproteins 1A, 1B, and 3, 4499 vinelandii, Clostridium pasteurianum, and Klebsiella pneumoniae, Protein phosphatase 3826 Adrenalglucocorticoid permissive regulation of muscle glycogenolysis: Iron-sulfur proteins: Spin-coupling model for three-iron clusters, 6574 Action on proteinphosphatase(s) and its inhibitor(s),5711 Protein kinase Protein phosphorylation Abnormalbehavior of interferon-inducedenzymatic activities in an see also Phosphoprotein interferon-resistantcell line, 4479 Actin nascent chains are substratesfor cyclic AMP-dependent Calcium-dependent protein kinase: Widespread occurrence in various phosphorylation in vivo, 910 tissues and phyla of animal kingdom and comparison of effects of Activationof braintryptophan hydroxylase by ATP-Mg2+:Dependence phospholipid, calmodulin, and trifluoperazine, 7039 on calmodulin,4688 Catalytic subunit of cyclic AMP-dependent protein kinase: Activationof pyruvatedehydrogenase by direct addition of insulin to an Microinjection enhances calcium action potentials of bag cell neurons isolated plasma membrane/mitochondria mixture: Generation of in cell culture, 7487 insulin's second messenger in a subcellular system, 77 Downloaded by guest on September 29, 2021 7594 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Calcium-regulatedphosphorylation in synaptosomalcytosol: Dependence Sex steroid-binding protein of plasma: Immunocytochemical localization on calmodulin,5812 in tissues of adult monkey Macaca nemestrina, 5678 Catalytic subunit of cyclic AMP-dependent protein kinase: Protein, single-strandbinding Microinjectionenhances calcium action potentialsof bag cell neurons Homologous pairing in genetic recombination: Formation of D loops by in cell culture, 7487 combinedaction of recA proteinand a helix-destabilizingprotein, 2606 Chloroplast phosphoproteins: Regulation of excitation energy transfer by Protein,structural phosphorylation of thylakoid membrane polypeptides, 5253 Majorstructural proteins of type B, type C, and type D oncoviruses Cyclic GMP-dependent protein kinase and substrate: Localization in share interspecies antigenic determinants, 72 mammaliancerebellum, 5537 Protein structure Dopamineand depolarizingagents regulatestate of phosphorylationof see also Amino acid sequence; Protein folding proteinI in mammaliansuperior cervical sympathetic ganglion, 7479 Carboxypeptidase A mechanisms, 3875 Double-stranded-RNA-activated kinase that phosphorylates a subunit of Electron micrographs of negatively stained protein molecules: Fidelity of eukaryotic initiation factor 2 (eIF-2a) in reticulocyte lysates, 832 structure representation, 4721 Intracellular injection of catalytic subunit of cyclic AMP-dependent Pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate protein kinase simulates facilitation of transmitter release underlying aminotransferase: Three-dimensional structure, 2559 behavioral sensitization in Aplysia, 7492 Rate of spontaneous mutation at human loci encoding protein structure, Phosphorylation and dephosphorylation of spectrin from human 6037 erythrocyte ghosts under physiological conditions: Autocatalysis rather Search for mutations affecting protein structure in children of atomic than reaction with separate kinase and phosphatase, 3264 bomb survivors: Preliminary report, 4221 Protein phosphorylationand sodiumconductance in nerve membrane, Three-dimensional structure of a protein from scorpion venom: New 812 structural class of neurotoxins, 6496 Pyrophosphate:protein : Membrane-bound enzyme of Protein synthesis endoplasmic reticulum, 1927 see also Peptide synthesis Regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase Auxin-induced changes in patterns of protein synthesis in soybean in vivo: Enzyme phosphorylation as an early regulatory response after hypocotyl, 357 intragastricadministration of mevalonolactone,6429 Cell-free coupled transcription-translation system for investigation of Site-specific phosphorylation of a subunit of eukaryotic initiation factor linear DNA segments, 7029 eIF-2 by heme-regulated and double-stranded RNA-activated eIF-2a Elongation factor Tu isolated from Escherichia coli mutants altered in kinases from rabbit reticulocyte lysates, 1286 tufA and tufB, 3922 Synthesis in vitro of full-length complement of negative-strand genome Energy relay: A proofreading scheme based on dynamic cooperativity RNA of vesicular stomatitis virus, 294 and lacking all characteristic symptoms of kinetic proofreading in Tyrosine hydroxylase: Substrate of cyclic AMP-dependent protein DNA replication and protein synthesis, 5248 kinase, 92 Initiation of protein synthesis in bacteria at a translational start codon of Protein, Pn mammalian cDNA: Effects of the preceding nucleotide sequence, 1442 Synthesis of glutamine synthetase regulated by PII protein in Klebsiella Major intracellular cations and growth control: Correspondence among aerogenes, 2636 magnesium content, protein synthesis, and onset of DNA synthesis in Protein, platelet basic BALB-c 3T3 cells (correction), 1721 Humanplatelet basic proteinassociated with antiheparinand mitogenic Mechanism of translocation: Relative arrangement of tRNA and mRNA activities:Purification and partialcharacterization, 5914 on the ribosome, 5110 Protein, posteriorindicator Overlapping genes at cheA locus of Escherichia coli, 5370 Synthesis of a posteriorindicator protein in normalembryos and double Progesterone inhibition of uterine nuclear estrogen receptor: Dependence abdomens of Smittia sp. (Chironomidae, Diptera), 6700 on RNA and protein synthesis, 5856 Protein, R Protein synthesis: Regulation during spore germination in Dictyostelium Cobalaminanalogues in animaltissues, 817 discoideum, 1791 Protein, recA Protein synthetic errors do not increase during aging of cultured human Duplex DNA containingsingle-stranded regions: Recognition by recA fibroblasts, 1885 protein,2569 Ribosomal protein L7/L12 is required for optimal translation, 4007 Escherichiacoli lexA protein:Cleavage by the recA protease,3225 Simian virus 40 and polyoma virus stimulate overall cellular RNA and Homologous pairing in genetic recombination: Formation of D loops by protein synthesis, 1476 combined action of recA protein and a helix-destabilizing protein, 2606 Site-specific phosphorylation of a subunit of eukaryotic initiation factor Initiation of genetic recombination: Homologous pairing between duplex eIF-2 by heme-regulated and double-stranded RNA-activated eIF-2a DNA molecules promoted by recA protein, 3962 kinases from rabbit reticulocyte lysates, 1286 recA protein-catalyzed strand assimilation: Stimulation by Escherichia Protein synthesis, cell-free coli single-stranded DNA-binding protein, 857 Adrenocorticotropic hormone increases specific proteins of the Sequences of recA gene and protein, 2611 mitochondrial fraction that are translated inside or outside this Protein,gag-related organelle in cultured adrenal tumor cells, 4648 Mutant of avian erythroblastosisvirus defective for erythroblast Cytoplasmically made subunits of yeast mitochondrial Fl-ATPase and transformation:Deletion in erb portionof p75 suggestsfunction of the cytochrome c oxidase are synthesized as individual precursors, not as protein in leukemogenesis,6683 polyproteins, 3998 Protein, replication Four cytoplasmically made subunits of yeast mitochondrial cytochrome c Escherichiacoli replicationprotein that recognizesa unique sequence oxidase are synthesized individually and not as a polyprotein, 4160 within a hairpinregion in kX174DNA, 799 Membrane-associated protein complex required for protein translocation Protein, ribosomal across endoplasmic reticulum: Purification, 7112 see also Gene, ribosomalprotein; Ribonucleoprotein Preprotein processing: Inhibition in ascites tumor lysates by Autogenous control of Escherichia coli ribosomal protein L10 synthesis incorporation of a leucine analog, 1356 in vitro, 2592 Proteins encoded by Agrobacterium tumefaciens Ti plasmid DNA BacteriophageX vehicle for direct cloningof Escherichiacoli promoter (T-DNA) in crown gall tumors, 2666 DNA sequences: Feedback regulation of rplJL-rpoBC operon, 2124 Receptor-mediated transcellular transport of immunoglobulin: Synthesis Feedbackregulation of ribosomalprotein gene expressionin Escherichia of secretory component as multiple and larger transmembrane forms, coli, 3590 7257 Immunoelectronmicroscopic localization of site of photo-induced Protein synthesis inhibition affinity labelingof small ribosomalsubunit with puromycin,890 Autogenous control of Escherichia coli ribosomal protein L10 synthesis Insulin-treated3T3-L1 adipocytes. and cell-freeextracts derived from in vitro, 2592 them incorporate32P into ribosomalprotein S6, 2641 Double-stranded RNA inhibits a phosphoprotein phosphatase present in In vitro expression of Escherichia coli ribosomal protein genes: interferon-treated cells, 107 Autogenous inhibition of translation, 1837 In vitro expression of Escherichia coli ribosomal protein genes: Ribosomal protein L7/L12 is required for optimal translation, 4007 Autogenous inhibition of translation, 1837 Ribosomal proteins: Expression during Drosophila early development, Lasting damage to bacterial ribosomes by reversibly bound virginiamycin 5649 M, 5492 Protein, saxitoxin-binding Prevalent deficiency in tumor cells of cycloheximide-induced cycle Saxitoxin binding protein/Na+ gate of mammalian brain: Molecular arrest, 4123 characterization,reconstitution, and "transport-specificfractionation", Protein topogenesis 6884 Intracellular protein topogenesis, 1496 Protein, secretory Protein, viral DNA sequenceencoding NH2-terminal peptide involvedin transportof X Adenovirus DNA replication in vitro: Characterization of a protein receptor, an Escherichia coli secretory protein, 2621 covalently linked to nascent DNA strands, 5105 Multiple forms of parathyroid secretory protein-I: Synthesis, Cloning DNA sequences from influenza viral RNA segments, 210 intracellular distribution, and secretion, 6406 Major gene product of Snyder-Theilen strain of feline sarcoma virus: Preprotein processing: Inhibition in ascites tumor lysates by Origin and functional properties, 5158 incorporation of a leucine analog, 1356 MultiplemRNA species for precursorto an adenovirus-encoded Regulation of production of secretory proteins: Intracellular degradation glycoprotein: Identification and structure of signal sequence, 6349 of newly synthesized "defective" collagen, 4746 Virus structural proteins and protein-protein interactions: Distribution Protein self-assembly in plasma membrane of baby hamster kidney cells infected with Kinetics of fiber-to-crystal transition of sickle cell hemoglobin: Electron Sindbis or vesicular stomatitis virus, 7277 microscope study, 944 Protein,zona pellucida Protein, sex steroid-binding Zonapellucida proteins: Synthesis by denudedand follicle-enclosed Phylogenyof sex steroid bindingplasma protein: Hormonal and mouse oocytes during culture in vitro, 1029 immunologicalaspects, 4578 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7595

Proteoglycan Tuberculoprotein derived from Mycobacterium tuberculosis: Heparansulfate-containing proteoglycan isolated from basement Radioimmunoassay, 4301 membrane, 4494 Rainbowtrout Prothrombin see Salmo gairdneri Cloning and analysis of a cDNA coding for bovine prothrombin, 5153 Ramanspectroscopy Proton-hydroxylpermeability Differencesin Fe(II)-N,(His-F8)stretching frequencies between Net proton-hydroxyl permeability of large unilamellar liposomes deoxyhemoglobins in the two alternative quaternary structures, 2033 measured by an acid-base titration technique, 2038 Exchange kinetics of Schiff base proton in bacteriorhodopsin, 6571 Proton transfer Rana catesbeiana Proton-translocatingadenosinetriphosphatase complex from /-Adrenergic receptor in frog erythrocyte membranes: Cytoskeletal chloroplasts: Biosynthesis and assembly, 1361 constraint,6401 Protoplastfusion Rana pipiens Biparentalproducts of bacterialprotoplast fusion showingunequal Right and left eye bands in frogs with unilateraltectal ablations,2314 parentalchromosome expression, 3553 --Ray perturbedangular correlation spectroscopy Pseudomonaeaeruginosa Targetingof lipid vesicles:Specificity of carbohydratereceptor analogues Pseudomonas aeruginosa mutant producing a nontoxic, immunologically for leukocytes in mice, 4430 crossreactive toxin A protein: Isolation and characterization, 7199 Reaction-diffusionmodel Pseudopod Scale-invariancein reaction-diffusionmodels of spatial pattern Spreading of fibroblasts in medium containing cytochalasin B: formation, 4180 Formationof lamellarcytoplasm as a combinationof several Receptor,acetylcholine functionally different processes, 5919 Acetylcholine receptor-controlled ion translocation across cell Pteridine membranes: Molecular mechanism, 842 Pteridines as nonretinal regulators of light-dependent melatonin Acetylcholine receptor site density affects rising phase of miniature biosynthesis, 2415 endplate currents, 3736 Pteroylpolyglutamate Acetylcholine receptors on myotubes: Crosslinkage and visualization with 5-Fluorouracil-methotrexate synergy: Enhancement of biotinylated a-bungarotoxin and fluorescent avidin, 4823 5-fluorodeoxyuridylate binding to thymidylate synthase by Activation, inactivation, and desensitization of acetylcholine receptor dihydropteroylpolyglutamates, 5663 channelcomplex detected by bindingof perhydrohistrionicotoxin,2309 Pulmonarymechanics Antibodies from myasthenic patients that compete with cholinergic Leukotrienes C-1 and D: Comparative airway and vascular activities in agents for binding to nicotinic receptors, 4326 vivo and in vitro, 4354 Attempt to distinguish between actions of neuromuscular blocking drugs Purine on the acetylcholine receptor and on its associated ionic channel, 5003 see also specific purines Carbohydrate requirement for expression and stability of acetylcholine Induction of differentiation of murine erythroleukemia cells by receptor on surface of embryonic muscle cells in culture, 5263 aminonucleoside of puromycin and inhibition of induction by purines Cation translocation by Torpedo acetylcholine receptor: Direct and purine derivatives, 2740 spectroscopic studies on a time scale of physiological relevance, 4509 Prolonged derangements of canine myocardial purine metabolism after a Denervation increases turnover rate of junctional acetylcholine receptors, brief coronary artery occlusion not associated with anatomic evidence 2293 of necrosis, 5471 a-Fetoprotein: Inhibitory effect on binding of myasthenia gravis Purkinjefiber antibody to acetylcholine receptor, 3635 Activation of electrogenic Na+/K+ exchange by extracellular K+ in Functional acetylcholine receptor from Torpedo marmorata in planar canine cardiacPurkinje fibers, 4035 membranes, 3052 Puromycin [3H]Phencyclidine: Probe for ionic channel of nicotinic receptor, 7458 Immunoelectronmicroscopic.localization of site of photo-induced Membrane-bound acetylcholine receptor from Torpedo marmorata: affinity labelingof small ribosomalsubunit with puromycin,890 Structural details, 952 Induction of differentiation of murine erythroleukemia cells by Monoclonal antibodies used to probe acetylcholine receptor structure: aminonucleoside of puromycin and inhibition of induction by purines Localization of main immunogenic region and detection of similarities and purine derivatives, 2740 between subunits, 755 Pyridoxal5'-phosphate Phencyclidine interactions with ionic channel of acetylcholine receptor Anion channelblockers inhibit lysosomalenzyme secretion from human and electrogenic membrane, 1224 neutrophilswithout affectinggeneration of superoxideanion, 2721 Reconstitution of functional membrane-bound acetylcholine receptor Pyridoxal-phosphate-dependentenzyme, mitochondrialaspartate from isolated Torpedo californica receptor protein and electroplax aminotransferase: Three-dimensional structure, 2559 lipids, 1796 Pyrocystis lunula Reconstitutionof purifiedacetylcholine receptors with functionalion Crossreactivity between light-emitting systems of distantly related channels in planar lipid bilayers, 3057 organisms: Novel type of light-emitting compound, 1394 Torpedo acetylcholine receptor subunits as a transmembrane complex: Pyrophosphate:proteinphosphotransferase Topographic studies, 5807 Pyrophosphate:protein phosphotransferase: Membrane-bound enzyme of Receptor, adenosine endoplasmic reticulum, 1927 Adenosine receptors in brain membranes: Binding of Pyrroline-5-carboxylate synthase N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8- 3H]phenylxanthine, Pyrroline-5-carboxylate synthase activity in mammalian cells, 5221 5547 Pyruvatecarboxylase (EC 6.4.1.1) Subclasses of external adenosine receptors, 2551 Pyruvate carboxylase apoenzyme and holoenzyme: Induction in 3T3-L1 Receptor,adenosine 3',5'-cyclic monophosphate cells during differentiation, 1321 Catabolite repression in Escherichia coli mutants lacking cyclic AMP Pyruvatedehydrogenase (lipoamide) (EC 1.2.4.1) receptor protein, 5799 Activationof pyruvatedehydrogenase by direct additionof insulin to an Escherichia coli L-arabinose operon: Binding sites of regulatory proteins isolated plasmamembrane/mitochondria mixture: Generation of and a mechanism of positive and negative regulation, 3346 insulin'ssecond messengerin a subcellularsystem, 77 Receptor,a-adrenergic Pyruvatekinase (EC 2.7.1.40) Agonist.versus antagonist binding to a-adrenergic receptors, 4569 Glucagon:Mechanism of action on hepatocytephosphofructokinase Regulation of cyclic AMP formation in brain tissue by a-adrenergic activity, 6501 receptors: Requisite intermediacy of prostaglandins of the E series, Permeabilizationof animal cells for kinetic studies of intracellular 3024 enzymes: In situ behavior of glycolytic enzymes of erythrocytes, 6324 Receptor,f-adrenergic 4,6-O-Pyruvyl-D-a-methylgalactoside /-Adrenergic receptor in frog erythrocyte membranes: Cytoskeletal Immunochemical determination of configuration of a haptenic constraint, 6401 substituent, 4244 /-Adrenergic receptors and guanine nucleotide sites: Interaction in turkey erythrocyte membranes, 3801 QBreplicase /-Adrenergic receptors: Induction and properties during erythroid Q/ replicase template specificity: Different templates require different differentiation of Friend leukemic cells, 4065 GTP concentrationsfor initiation,2601 Adrenergic regulation of intraocular pressure: Identification of Quercetin /2-adrenergic-stimulated adenylate cyclase in ciliary process Fecalase:A model for activationof dietaryglycosides to mutagensby epithelium, 7420 intestinal flora, 4961 Agonist-promoted coupling of /-adrenergic receptor with guanine Quercetininhibits Ca2+uptake but not Ca2+release by sarcoplasmic nucleotide regulatory protein of the adenylate cyclase system, 775 reticulumin skinnedmuscle fibers, 4435 Anti-alprenolol anti-idiotypic antibodies bind to /-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase, 7385 Radioautography Functional implantation of a solubilized /-adrenergic receptor in see Autoradiography membrane of a cell, 760 Radioimmunoassay Hormone-receptor interactions are noncooperative: Application to 16a-[125I]Iodoestradiol:Interaction with estrogenreceptor and other /-adrenergic receptor, 4340 steroid-bindingproteins, 328 Macromolecular /-adrenergic .antagonists discriminating between Insulin is ubiquitousin extrapancreatictissues of rats and humans,572 receptor and antibody, 2219 Majorstructural proteins of type B, type C, and type D oncoviruses Mepacrine blocks /3-adrenergic agonist-induced desensitization in share interspeciesantigenic determinants, 72 astrocytoma cells, 1341 Multiplication-stimulatingactivity, an insulin-likegrowth factor: Monoclonal antibodies to /-adrenergic receptors: Use in purification and Increased levels in fetal rat serum, 3649 molecular characterization of /-receptors, 7034 Radioimmunoassay for vitamin K-dependent protein of bone and its Photoaffinity label for /-adrenergic receptor: Synthesis and effects on discovery in plasma, 2234 isoproterenol-stimulated adenylate cyclase, 4449 Downloaded by guest on September 29, 2021 7596 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Receptor, y-aminobutyricacid Receptor,lutropin y-Aminobutyricacid receptors:Autoradiographic localization in rat Aggregationof luteinizinghormone receptors in granulosacells: Possible cerebellum,670 mechanismof desensitizationto the hormone,3440 Receptor,asialoglycoprotein Macromolecularphotoaffinity labeling of lutropinreceptor on granulosa Hepatic asialoglycoproteinreceptor: Reconstitution with phospholipid cells, 7167 vesicles,5087 Receptor,morphine Receptor,bacteriophage X Distinct morphineand enkephalinreceptors: Possible role in mediating DNA sequenceencoding NH2-terminal peptide involvedin transportof X actions of benzomorphandrugs (putativeK and a agonists),4469 receptor,an Escherichiacoli secretoryprotein, 2621 Receptor,nerve growthfactor Specificityof diffusionchannels produced by Xphage receptorprotein of Nerve growthfactor: Mobility, clustering, and transportin embryonal Escherichiacoli, 167 sensorycells and in a sympatheticneuronal cell line, 3469 Synthesis and maturationof Xreceptor in Escherichiacoli K-12:In vivo Nerve growthfactor receptors on PC12 cells: Ligand-inducedconversion and in vitro expressionof gene lamB under lac promotercontrol, 1491 from low- to high-affinitystates, 4751 Receptor,benzodiazepine Receptor,nicotinic Barbituratereceptor sites are coupledto benzodiazepinereceptors, 7468 Antibodiesfrom myasthenicpatients that competewith cholinergic Benzodiazepinereceptor protein identified and visualizedin braintissue agents for bindingto nicotinicreceptors, 4326 by photoaffinitylabel, 1666 [3H]Phencyclidine:Probe for ionic channelof nicotinicreceptor, 7458 Urinaryand brain/-carboline-3-carboxylates as potent inhibitorsof Receptor,noradrenergic brainbenzodiazepine receptors, 2288 Noradrenergical and a2 receptors:Light microscopicautoradiographic Receptor,cell surface localization,1696 Clone-specificcellular recognition in a sea anemone,6667 Receptor,opiate Model for cappingderived from inhibitionof surfacereceptor capping by Autoradiographyin vitro of opiate receptorsin rat brain suggestsloci of free fatty acids, 437 "opiatergic"pathways, 5532 Receptor-mediateduptake of 3,3',5-triiodo-L-thyronineby cultured Selective protectionof stereospecificenkephalin and opiate binding fibroblasts,3425 againstinactivation by N-ethylmaleimide:Evidence for two classes of Targetingof lipid vesicles:Specificity of carbohydratereceptor analogues opiate receptors,281 for.leukocytesin mice, 4430 Solubilizationof active opiate receptors,4623 Receptor,cholinergic Stress-inducedrelease of prolactin:Blockade by dexamethasoneand SubstanceP enhancescholinergic receptor desensitization in a clonal naloxonemay indicate /-endorphin mediation,666 nerve cell line, 634 Receptor,b-opiate A T lymphocytecholinergic receptors: Electrophysiology, 4317 Differentiationof I- and p-opiatereceptor localizations by light Receptor,concanavalin A microscopicautoradiography, 6239 I and i antigensof humanperipheral blood lymphocytescocap with Guineapig intestinalelectrolyte secretion: Control by a b-opiate receptorsfor concanavalinA, 376 receptor,2753 Receptor,corticotropin Receptor,purinergic Photoaffinitylabeling of corticotropinreceptors, 3967 Putative centralpurinergic receptors: Biochemical characterization by Receptor,dopaminergic using 2-chloro[3H]adenosine,a stable analogof adenosine,6892 Pergolide:Interaction with centraldopaminergic receptors, 3725 Receptor,thyroid hormone Receptor,enkephalin Affinity labelingof rat liver thyroidhormone nuclear receptor, 7064 Clusterformation of opiate (enkephalin)receptors in neuroblastoma Receptor,vasopressin cells: Differencesbetween agonists and antagonistsand possible Insulin and serumincrease number of receptorsfor vasopressinin a relationshipsto biologicalfunctions, 3038 kidney-derivedline of cells grownin a defined medium,5979 Distinct morphineand enkephalinreceptors: Possible role in mediating Receptor,virus actions of benzomorphandrugs (putativeK and a agonists),4469 Sendai virus utilizes specific sialyloligosaccharidesas host cell receptor Receptor,epidermal growth factor determinants,5693 Geneticsof cell surfacereceptors for bioactivepolypeptides: Binding of Receptor,vitamin D epidermalgrowth factor is associatedwith the presenceof human Receptor-likeprotein for 1,25-dihydroxyvitaminD3 in rat skin: chromosome7 in human-mousecell hybrids,3600 Characterization,5822 Lysomotropicamines cause intracellularaccumulation of receptorsfor Recombination,genetic epidermalgrowth factor, 3283 DNA synaptase:An enzymethat fuses DNA moleculesat a regionof Transforminggrowth factors produced by certainhuman tumor cells: homology,2390 Polypeptidesthat interactwith epidermalgrowth factor receptors, Duplex DNA containingsingle-stranded regions: Recognition by recA 5258 protein,2569 Receptor,Epstein-Barr virus Evolutionof recombinationin a constant environment,4838 Transferof Epstein-Barrvirus receptorsto receptor-negativecells Gene expression:Control by a mobile recombinationalswitch, 4880 permitsvirus penetrationand antigen expression,5453 Geneticrecombination of bacterialplasmid DNA: Electronmicroscopic Receptor,estradiol analysisof in vitro intramolecularrecombination, 4847 Estradiol-receptorcomplexes: Enrichment in transcriptionallyactive Homologouspairing in genetic recombination:Formation of D loops by fractionof chromatinfrom MCF-7cells, 1291 combinedaction of recAprotein and a helix-destabilizingprotein, 2606 Oligodeoxynucleotidebinding of mouse uterine cytosol estradiol Initiationof genetic recombination:Homologous pairing between duplex receptors:Specificity, 3341 DNA moleculespromoted by recA protein,3962 Receptor,estrogen Recombination,mitotic 16a-[125I]Iodoestradiol:Interaction with estrogenreceptor and other Enhancementof N-methyl-N'-nitro-N-nitrosoguanidinetransformation steroid-bindingproteins, 328 of Syrianhamster cells by a phorboldiester is independentof sister Monoclonalantibodies to estrophilin:Probes for study of estrogen chromatidexchanges and chromosomeaberrations, 7282 receptors,157 Mitotic recombinationin yeast: Inductionby starvationfor thymine Monoclonalantibodies to humanestrogen receptor, 5115 nucleotides,6057 Progesteroneinhibition of uterine nuclearestrogen receptor: Dependence RAD52gene is requiredfor homothallicinterconversion of matingtypes on RNA and proteinsynthesis, 5856 and spontaneousmitotic recombinationin yeast, 503 Receptor,ethylketocyclazocine Renal tubule Multiple opiate receptors:[3H]Ethylketocyclazocine receptor binding Couplingof active ion transportand aerobicrespiratory rate in isolated and ketocyclazocineanalgesia, 3691 renaltubules, 447 Receptor,glucocorticoid Inductionof basementmembrane glycoprotein in embryonickidney: Antiserumto the rat liver glucocorticoidreceptor, 3893 Possible role of lamininin morphogenesis,485 Unique long-actingantiglucocorticoid in whole and brokencell systems, Renin 5167 Immunoreactiverenin: Wide distributionin nerve cells of humanbrain, Receptor,immunoglobulin 5458 Isolationand partialchemical characterization of IgG Fc receptorof Ornithinedecarboxylase: Induction by renin-freenerve growth factor, humanT lymphocytesand productionof an antiserum,3645 4607 Phospholipidmethylation, Ca2+ influx, and histaminerelease: Specific inhibition of renin by an angiotensinogen analog: Sodium Stimulationby bridgingof IgE receptorson rat mast cells, 1903 depletionand renin-dependenthypertension, 5476 Subpopulationsof humanperipheral granulocytes and monocytes Renin (EC 3.4.99.19) expressreceptors for IgA, 3640 Membrane-boundkallikrein and renin in the kidney:Activation, 4975 Receptor,insulin Reovirus. Differencesin organizationalstructure of insulin receptoron rat Reovirus-inducedmodification of cap-dependenttranslation in infected adipocyteand liver plasmamembranes: Role of disulfidebonds, 4692 L cells, 152 Electrophoreticresolution of three majorinsulin receptorstructures with Repressor,lac unique subunit stoichiometries, 7137 Lactose repressor protein and its interaction with ligands: Model, 7181 Insulin receptor synthesis and turnover in differentiating 3T3-L1 Photochemically induced dynamic nuclear polarization investigation of preadipocytes, 285 complex formation of the NH2-terminal DNA-binding domain of lac Regulation of insulin binding to isolated hepatocytes: Correction for repressor with poly[d(AT)], 5145 bound hormone fragments linearizes Scatchard plots, 3176 Reproduction Regulation of insulin receptors: Evidence for involvement of an Photoaffinity labeling of rat androgen-binding protein, 234 endocytotic internalization pathway, 5975 Reserpine Receptor, low density lipoprotein Synthesis of enkephalins by adrenal medullary chromaffin cells: Low density lipoprotein receptor activity in human monocyte-derived Reserpine increases incorporation of radiolabeled amino acids, 4364 macrophages and its relation to atheromatous lesions, 5466 Restrictionendonuclease Platelet-derived growth factor stimulates low density lipoprotein see also Endodeoxyribonuclease BamHI; Endonuclease receptor activity in cultured human fibroblasts, 5962 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7597

Cloning and direct examination of a structurally abnormal human Rhodamine,tetramethyl- 3-thalassemia globin gene, 3558 Receptor-mediateduptake of 3,3',5-triiodo-L-thyronineby cultured Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences fibroblasts,3425 as BamHI fragments, 4201 Rhodopseudomonassphaeroides Comparison of two b-crystallin genes in chicken, 5879 Electrontransport. Inhibition by orthophenanthrolinein Epstein-Barr virus (B95-8) DNA VII: Molecular cloning and detailed chromatophoresand reactioncenters of Rhodopseudomonas mapping, 2999 sphaeroides,'1809 Gene deletions in a thalassemia prove that the 5' S locus is functional, Flash-activatedcyclic electrontransport system constructedby using 3586 bacterialreaction centers and ubiquinone-cytochromeb-cl/c segment Linkage of aG-Philadelphia to a-thalassemia in African-Americans, 4885 of mitochondria,6339 Maternal inheritance of human mitochondrial DNA, 6715 Pigment-proteincomplexes of Rhodopseudomonassphaeroides: Mitochondrial DNA polymorphism: Variants detected by restriction Isolationand characterizationby lithium dodecyl enzymes differ in nucleotide sequence rather than in methylation, 6415 sulfate/polyacrylamidegel electrophoresis,87 Molecular cloning of infectious integrated murine leukemia virus DNA Rhodopsin from infected mouse cells, 614 see also Bacteriorhodopsin Molecular cloning of unintegrated Moloney mouse sarcoma virus DNA in Additionalcomponent required for activity and reconstitutionof bacteriophage X, 1773 light-activatedvertebrate photoreceptor GTPase, 1408 Moloney mouse sarcoma virus-specific sequences from uninfected mouse Photolyzedrhodopsin catalyzes exchange of GTP for bound GDP in cells: Identification and molecular cloning, 2651 retinal rod outer segments,2500 Plasmid-dependent temperature-sensitive phase in crown gall Wavelengthregulation in rhodopsin:Effects of dipoles and amino acid tumorigenesis, 2688 side chains,6314 Polymorphism in mitochondrial DNA of humans as revealed by Rho factor restriction endonuclease analysis, 3605 Cataboliterepression in Escherichiacoli mutants lackingcyclic AMP Prenatal diagnosis of sickle cell anemia by restriction endonuclease receptorprotein, 5799 analysis: HindIII polymorphisms in y-globin genes extend test Ribofuranosylbenzimidazole,5,6-dichloro-1-ft- applicability, 2853 5,6-Dichloro-l-/-ribofuranosylbenzimidazoleenhances premature Proportion of hemoglobin G Philadelphia (oa268Asn-LyS2) in terminationof late transcriptionof simianvirus 40 DNA, 3297 heterozygotes is determined by interaction with a-globin gene Kinetics of decay in expression of interferon-dependent mRNAs deletions, 6874 responsible for resistance to virus, 452 Silent 6-globin gene in Old World monkeys, 3563 RibonucleaseA Triplicated a-globin loci in humans, 518 Proline cis-trans isomerization involved in the slow unfolding reaction of Trypanosoma cruzi: Strains and clones can be characterized by pattern RNase A, 795 of restriction endonuclease products of kinetoplast DNA minicircles, RibonucleaseD 6810 Ribonuclease D: Apparent involvement in 3' processing of tRNA Reticulocyte precursors, 837 see also Membrane, reticulocyte RibonucleaseH ATP-dependent conjugation of reticulocyte proteins with polypeptide Formation of a RNA primer for initiation of replication of ColEl DNA required for protein degradation, 1365 by , 2450 Double-stranded RNA-activated eukaryotic initiation factor 2 kinase RibonucleaseII from rabbit reticulocytes: Purification and properties, 6526 Ribonuclease D: Apparent involvement in 3' processing of tRNA Proposed role of ATP in protein breakdown: Conjugation of proteins precursors,837 with multiple chains of polypeptide of ATP-dependent proteolysis, RibonucleaseM5 1783 Recognition of local nucleotide conformation in contrast to sequence by Retina a rRNA processingendonuclease, 5644 Choline accumulation by photoreceptor cells of rabbit retina, 1671 -peptide Interplexiform cell in cat retina: Identification by uptake of Camphorquinone-10-sulfonic acid and derivatives: Convenient reagents -y-[3H]aminobutyric acid and serial reconstruction, 658 for reversible modification of arginine residues, 895 Light adaptation and temperature effects in rat PIII retinal response: Ribonticleicacid Analysis with a two-state model, 4021 see also Hybridization, nucleic acid Light-induced calcium release by intact retinal rods, 5557 Ribonucleicacid, capped Ontogenetic patterns of thyrotropin-releasing hormone-like material in Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA rat hypothalamus, pancreas, and retina: Selective effect of light strongly influence its ability to act as primer for influenza virus RNA deprivation, 4345 transcription, 3952 Photolyzed rhodopsin catalyzes exchange of GTP for bound GDP in Priming and inhibitory activities of RNAs for influenza viral retinal rod outer segments, 2500 transcriptase do not require base pairing with virion template RNA, Retinal rhythms in chicks: Circadian variation in melatonin and 5874 serotonin N-acetyltransferase activity, 4998 Reovirus-induced modification of cap-dependent translation in infected Scrapie agent: Replication in ocular neural tissues, 1169 L cells, 152 Somatostatin-like immunoreactivity in retina, 1691 Ribonucleicacid, double-stranded Retinoic acid Abnormalbehavior of interferon-inducedenzymatic activities in an Differentiation of human promyelocytic leukemia cell line (HL-60): interferon-resistant cell line, 4479 Induction by retinoic acid, 2936 Double-stranded-RNA-activated kinase that phosphorylates a subunit of Retinoyl /-glucuronide: Characterization as a minor metabolite of eukaryotic initiation factor 2 (eIF-2a) in reticulocyte lysates, 832 retinoic acid in bile, 3230 Double-stranded RNA inhibits a phosphoprotein phosphatase present in Retinoyl /-glucuronide interferon-treated cells, 107 Retinoyl /-glucuronide: Characterization as a minor metabolite of Extrachromosomal genetic elements: Preferential inclusion in yeast retinoic acid in bile, 3230 meiotic spores, 5380 Retrovirus "Superkiller" mutations suppress chromosomal mutations affecting Mutant and recombinant avian retroviruses with extended host range, double-stranded RNA killer plasmid replication in Saccharomyces 536 cerevisiae, 527 Nucleotide sequences of integrated Moloney sarcoma provirus long Ribonucleicacid, heterogeneousnuclear terminal repeats and their host and viral junctions, 3937 Repeating structure of cytoplasmic poly(A)-ribonucleoprotein, 1890 Structure of a cloned circular Moloney murine leukemia virus DNA Specific RNA-cleaving activities from HeLa cells, 2395 molecule containing an inverted segment: Implications for retrovirus Ribonucleicacid ligase integration, 3932 see Polyribonucleotide synthetase (ATP) Synthesis and circularization of N- and B-tropic retroviral DNA in Fv-1 Ribonucleicacid, messenger permissive and restrictive mouse cells, 2994 see also Gene; Ribonucleic acid, viral Two species of full-length cDNA are synthesized in high yield by Mechanism of translocation: Relative arrangement of tRNA and mRNA melittin-treated avian retrovirus particles, 847 on the ribosome, 5110 Review Nucleotide sequence divergence and functional constraint in mRNA Ecological and evolutionary significance of mycorrhizal symbioses in evolution, 7328 vascular plants (A Review), 2113 Posttranscriptional modification of mRNA conformation: Mechanism Rhesus monkey that regulates erythromycin-induced resistance, 7079 see Macaca mulatta RNA encoded by eukaryotic transposable element copia: Translation Rhizobium and developmental regulation, 7107 Rhizobium nitrogen fixation: Regulation by unadenylylated glutamine Untranslated mRNA for a chorion protein of Drosophila melanogaster synthetase I system, 5817 accumulates transiently at onset of specific gene amplification, 5789 Rhizobiummeliloti Ribonucleicacid, messenger,albumin Broad host range DNA cloning system for Gram-negative bacteria: Albumin mRNA absent in liver of analbuminemic rats, 3215 Construction of a gene bank of Rhizobium meliloti, 7347 Ribonucleicacid, messenger,alkylation Nitrogenase genes: Interspecies homology, 191 Effect of introduction of small alkyl groups on mRNA function, 1983 Rhodamine Ribonucleicacid, messenger,calcitonin Effect of bleaching light on measurements of lateral diffusion in cell Rat calcitoninmRNA, 4444 membranes by fluorescence photobleaching recovery method, 2043 Ribonucleicacid, messenger,discoidin I Mitochondria: Localization in living cells with rhodamine 123, 990 Change in rate of transcription of a eukaryotic gene in response to cyclic Nerve growth factor: Mobility, clustering, and transport in embryonal AMP, 7171 sensory cells and in a sympathetic neuronal cell line, 3469 Ribonucleicacid, messenger,dopa decarboxylase Inductionof translatablemRNA for dopa decarboxylasein Drosophila: Early response to ecdysterone, 4175 Downloaded by guest on September 29, 2021 7598 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Ribonucleicacid, messenger,Escherichia coli Proton-coupled conformational switch of Escherichia coli 5S ribosomal RNA from the rplJL-rpoBCtranscription unit of Escherichiacoli: RNA, 3360 Attenuationand processing,3331 Recognition of local nucleotide conformation in contrast to sequence by Ribonucleicacid, messenger,a-fetoprotein a rRNA processing endonuclease, 5644 a-Fetoproteingene in the mouse:Structure, 1351 Ribonucleicacid, sea urchin' Ribonucleicacid, messenger,globin Four sizes of transcript produced by a single sea urchin gene expressed Embryonic-fetalerythroid characteristics of a humanleukemic cell line, in early embryos, 3259 3509 Messenger RNA prevalence in sea urchin embryos measured with cloned Processingof humanp-globin mRNA precursorto mRNA is defective in cDNAs, 5317 three patients with /+-thalassemia, 4287 Ribonucleicacid, small nuclear Ribonucleicacid, messenger,histone RNA splicing: Mechanism, 1877 Leadersequences of Strongylocentrotuspurpuratus histone mRNAs Ribonucleicacid splicing start at a unique heptanucleotidecommon to all five histone genes, RNA splicing: Mechanism, 1877 1265 Ribonucleicacid structure Multiple formsof H4 histone mRNA in humancells, 1942 see also Nucleotide sequence Ribonucleicacid, messenger,interferon Chemical probes for higher-order structure in RNA, 4679 Le interferonmRNA from humanfibroblasts, 5341 Fast algorithm for predicting secondary structure of single-stranded Regulationof stability of poly(I).poly(C)-inducedhuman fibroblast RNA, 6309 interferonmRNA: Selective inactivationof interferonmRNA and lack Regulation of histidine operon of Salmonella: Model, 508 of involvementof 2',5'-oligo(A)synthetase activation during shutoff of Ribonucleicacid synthesis interferonproduction, 3489 Comparison in vitro of initiation properties of bacteriophage X wild-type Synthesis'ofnew proteinsassociated with inductionof interferonin PR and x3 mutant promoters, 6381 humanfibroblast cells, 4918 DNA-dependent transcription of adenovirus genes in a soluble whole-cell Two interferonmRNAs in humanfibroblasts: In vitro translationand extract, 3855 Escherichiacoli cloningstudies, 7152 Formylmethionyl-tRNA alters RNA polymerase specificity, 870 Ribonucleicacid, messenger,low-abundance Progesterone inhibition of uterine nuclear estrogen receptor: Dependence Molecularcloning of developmentallyregulated, low-abundance mRNA on RNA and protein synthesis, 5856 sequencesfrom embryonicmuscle, 4519 Rate-limiting steps in RNA chain initiation, 5634 Ribonucleicacid, messenger,lysozyme RNA polymerase activity: Inhibition by Escherichia coli protein Exons encode functionaland structuralunits of chickenlysozyme, 5759 biosynthesis elongation factor Ts, 866 Ribonucleicacid, messenger,mouse Simian virus 40 and polyoma virus stimulate overall cellular RNA and Quantitationof mRNAs duringmouse spermatogenesis:Protamine-like protein synthesis, 1476 histone and phosphoglyceratekinase-2 mRNAs increaseafter meiosis, Simian virus 40 early transcription: Regulation in vitro by a purified 6086 tumor antigen, 5706 Ribonucleicacid, messenger,myosin heavy chain Synthesis in vitro of full-length complement of defective-interfering Cytoplasmicprocessing of myosin heavy chain messengerRNA: Evidence particle RNA of vesicular stomatitis virus, 3927 providedby using a recombinantDNA plasmid,5749 Ribonucleicacid, transfer Ribonucleicacid, messenger,plant see also Gene, transfer ribonucleic acid In vitro synthesis of pre-proteinsof vacuolarcompartmented proteinase Composite tRNA gene constructed by anticodon loop transplant, 5092 inhibitorsthat accumulatein leaves of woundedtomato plants, 1975 Conformationalchanges during enzyme catalysis: Role of water in the Ribonucleicacid, messenger,polyadenylylated transition state, 3374 Couldpoly(A) align splicingsites of messengerRNA precursors?1278 Formylmethionyl-tRNA alters RNA polymerase specificity, 870 Developmentalshifts in frequencydistribution of polysomalmRNA and Hydrolysis of GTP on elongation factor Tu-ribosome complexes their posttranscriptionalregulation in sea urchinembryo, 4653 promoted by 2'(3')-O-L-phenylalanyladenosine, 905 MessengerRNA prevalencein sea urchinembryos measured with cloned Mechanism of translocation: Relative arrangement of tRNA and mRNA cDNAs, 5317 on the ribosome,5110 Polycistronicvesicular stomatitis virus RNA transcripts,4662 Nuclear Overhauser effect in specifically deuterated macromolecules: Ribonucleicacid, messenger,procollagen NMR assay for unusual base pairing in transfer RNA, 5659 Parathyroidhormone alters collagensynthesis and procollagenmRNA Predicting coding function from nucleotide sequence or survival of levels in fetal rat calvaria,5654 "fitness" of tRNA, 3539 Ribonucleicacid, messenger,tetrahydrofolate dehydrogenase Ribonuclease D: Apparent involvement in 3' processing of tRNA Cell cycle regulationof dihydrofolatereductase mRNA metabolismin precursors, 837 mouse fibroblasts,5140 Selenium-containing tRNAs from Clostridium sticklandii: Ribonucleicacid, messenger,thyrotropin Cochromatography of one species with L-prolyl-tRNA, 1403 DNA sequencescomplementary to mRNAs for a and / subunits of Structures of free and ribosome-bound tRNAPhe: Comparison by using thyrotropin:Synthesis, cloning, and identification,3149 slow tritium exchange, 5135 Ribonucleicacid, messenger,yeast Thermally induced biosynthesis of 2'-O-methylguanosine in tRNA from Synthesis of repressibleyeast acid phosphatasein vitro:Identification of an extreme thermophile, Thermus thermophilus HB27, 1922 multiplemRNAs and products,4504 tRNA evolution: Convergence and minimal mutation criteria for Yeast genes with mRNA levels controlledby phosphateconcentration: evaluating early events, 2791 Isolation,6541 Two control regions for eukaryotic tRNA gene transcription, 3365 Ribonucleicacid, nuclear Ribonucleicacid, transfer,mitochondrial Transcriptionof mouse Kchain genes:Implications for allelic exclusion, Codon recognition rules in yeast mitochondria, 3167 1937 Different pattern of codon recognition by mammalian mitochondrial Ribonucleicacid nucleotidyltransferase tRNAs, 3164 Clonedmaize chloroplastDNA sequences:Preferential transcription by Genetic code and codon reading patterns in Neurospora crassa maize chloroplastRNA polymerase,822 mitochondria: Novel features based on sequences of six mitochondrial Comparisonin vitro of initiation propertiesof bacteriophageX wild-type tRNAs, 3159 PR and x3 mutant promoters,6381 Ribonucleicacid, viral Escherichiacoli RNA polymerasein vitro mimics simian virus 40 in vivo A small RNA induced late in simian virus 40 infection can associate with transcriptionwhen the template is viral nucleoprotein,6556 early viral mRNAs, 1379 Novel RNA polymerasea factor from Bacillus subtilis, 7000 Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA Prokaryotichistone-like protein interactingwith RNA polymerase,3548 strongly influence its ability to act as primer for influenza virus RNA Rate-limitingsteps in RNA chain initiation,5634 transcription, 3952 Ribonucleicacid nucleotidyltransferase(EC 2.7.7.6) Cloning DNA sequences from influenza viral RNA segments, 210 Contactsbetween Escherichia coli RNA polymeraseand an early Cloning of DNA complementary to measles virus mRNA encoding promotorof phage T7, 122 nucleocapsid protein, 3686 Formylmethionyl-tRNAalters RNA polymerasespecificity, 870 Conformation of helical nucleocapsids of paramyxoviruses and vesicular RNA polymeraseactivity: Inhibition by Escherichiacoli protein stomatitis virus: Reversible coiling and uncoiling induced by changes biosynthesiselongation factor Ts, 866 in salt concentration, 2631 5'-Terminaloligonucleotide fragments of RNA transcriptssynthesized by Fujinami sarcoma virus: Avian RNA tumor virus with a unique bacteriophageT3-induced RNA polymerasefrom T3 DNA: Isolation transforming gene, 2018 and sequencedetermination, 3908 Genes for virus-associated RNAi and RNAnI of adenovirus type 2: Ribonucleicacid polymerase Structure, 2424 see Ribonucleicacid nucleotidyltransferase Genetic structure of avian myeloblastosis virus, released from Ribonucleicacid precursor transformed myeloblasts as a defective virus particle, 5120 Electronmicroscope study of duck globin mRNA precursorcrosslinked Influenza defective interfering viral RNA is formed by internal deletion in situ, 4683 of genomic RNA, 215 Specific RNA-cleaving activities from HeLa cells, 2395 Kinetics of decay in expression of interferon-dependent mRNAs Ribonucleic acid, ribosomal responsible for resistance to virus, 452 see also Gene, ribosomal ribonucleic acid Mapping of two overlapping genes for polypeptides NS1 and NS2 on Complete nucleotide sequence of 23S ribosomal RNA gene from RNA segment 8 of influenza virus genome, 1857 Escherichia coli, 201 Most sequence differences between genomes of Akv virus and a Feedback regulation of ribosomal protein gene expression in Escherichia leukemogenic Gross A virus passaged in vitro are located near the 3' coli: Structural homology of ribosomal RNA and ribosomal protein terminus, 4359 mRNA, 7084 Multiple mRNA species for precursor to an adenovirus-encoded Mycoplasmas: Phylogenetic analysis, 494 glycoprotein: Identification and structure of signal sequence, 6349 Processing of precursors of 21S ribosomal RNA from yeast mitochondria, Nucleotide sequence of a cDNA clone derived from common region of 1417 avian sarcoma virus messenger RNA: Unusual features, 176 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7599

Nucleotide sequence of influenza virus RNA segment 8 indicates that Structure of a split yeast gene: Complete nucleotide sequence of actin coding regionsfor NS1 and NS2 proteinsoverlap, 5074 gene in Saccharomyces cerevisiae, 2546 OK10, an avian acute leukemia virus of the MC29 subgroup with a "Superkiller" mutations suppress chromosomal mutations affecting uniquegenetic structure,7142 double-stranded RNA killer plasmid replication in Saccharomyces Polycistronic vesicular stomatitis virus RNA transcripts, 4662 cerevisiae, 527 Priming and inhibitory activities of RNAs for influenza viral Synthesis of repressibleyeast acid phosphatasein vitro:Identification of transcriptase do not require base pairing with virion template RNA, multiple mRNAs and products,4504 5874 Yeast genes with mRNA levels controlled by phosphate concentration: Purification of a factor that restores translation of vesicular stomatitis Isolation, 6541 virus mRNA in extracts from poliovirus-infected HeLa cells, 770 Yeast ribosomalRNA genes:Replication and meiotic transmission,6739 Q/3replicase template specificity: Different templates require different Saccharomycescerevisiae mating type GTP concentrations for initiation, 2601 Mutations preventing transpositions of yeast mating type alleles, 2824 Regulation of herpesvirus macromolecular synthesis: RAD52 gene is required for homothallic interconversion of mating types Transcription-initiationsites and domainsof a genes, 7122 and spontaneous mitotic recombination in yeast, 503 Sequence of picornavirus RNAs containing a radioiodinated 5'-linked Yeast mating pheromone a factor inhibits adenylate cyclase, 1898 peptide reveals a conserved 5' sequence, 303 Saccharomycesitalicus Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as Association of 2-,m DNA plasmid with yeast folded chromosomes, 3144 determined by a modification of the dideoxynucleotide method, 3196 Saccharomycesmating type Synthesis in vitro of full-length complement of negative-strand genome Transposable mating type cassettes in Saccharomyces : Structure RNA of vesicular stomatitis virus, 294 and organization, 2839 Variations in properties of virus released from morphologically different Salmo gairdneri cell lines transformed in vitro by Friend leukemia virus, 5769 Biochemical studies of olfaction: Isolation, characterization, and odorant Vero cells injected with adenovirus type 2 mRNA produce authentic binding activity of cilia from rainbow trout olfactory rosettes, 4412 viral polypeptide patterns: Early mRNA promotes growth of Salmon adenovirus-associated virus, 931 see Oncorhynchus gorbuscha Vero cells injectedwith adenovirustype 2 mRNA produceauthentic Salmonella viral polypeptide patterns: Early mRNA promotes growth of Inversions of specific DNA segments in flagellar phase variation of adenovirus-associated virus (correction), 3070 Salmonella and inversion systems of bacteriophages P1 and Mu, 7338 Ribonucleoprotein Regulation of histidine operon of Salmonella: Model, 508 Native ribonucleoprotein is an efficient transcriptional complex of avian Salmonella typhimurium myeloblastosis virus, 1296 Nucleotidesequence of Salmonella typhimuriumorigin of DNA Repeating structure of cytoplasmic poly(A)-ribonucleoprotein, 1890 replication, 2460 Specific transcription factor that can bind either the 5S RNA gene or 5S Regulation of Tn5 transposition in Salmonella typhimurium, 6047 RNA, 4170 Sanfilippodisease Ribonucleoside-diphosphatereductase (EC 1.17.4.1) Sanfilippo disease type D: Deficiency of N-acetylglucosamine-6-sulfate Multienzyme complex for metabolic channeling in mammalian DNA sulfatase required for heparan sulfate degradation, 6822 replication, 3312 Sarcolemma Ribosome Charge movements during Na+/Ca2+ exchange in heart sarcolemmal see also Protein, ribosomal;Ribonucleoprotein; Ribonucleic acid, vesicles, 6354 ribosomal Saxitoxin-binding component of excitable membrane sodium channel: Crystalline ribosomes are present in brains from senile humans, 2260 Purification from rat sarcolemma, 1306 Feedback regulation of ribosomal protein gene expression in Escherichia Sarcomavirus, avian coli: Structural homology of ribosomal RNA and ribosomal protein Nucleotide sequence of a cDNA clone derived from common region of mRNA, 7084 avian sarcoma virus messenger RNA: Unusual features, 176 Hydrolysis of GTP on elongation factor Tu.ribosome complexes Protein encoded by transforming gene of avian sarcoma virus (pp60Orc) promoted by 2'(3')-O-L-phenylalanyladenosine, 905 and a homologous protein in normal cells (pp60Proto-src)are associated Immunoelectronmicroscopic localization of site of photo-induced with plasma membrane, 3783 affinity labeling of small ribosomal subunit with puromycin, 890 Y73, an avian sarcoma virus: A unique transforming gene and its Lasting damage to bacterial ribosomes by reversibly bound virginiamycin product, a phosphopolyprotein with protein kinase activity, 6199 M, 5492 Sarcomavirus, feline Mechanism of translocation: Relative arrangement of tRNA and mRNA Major gene product of Snyder-Theilen strain of feline sarcoma virus: on the ribosome, 5110 Origin and functional properties, 5158 Recognition of local nucleotide conformation in contrast to sequence by Sarcomavirus, Fujinami a rRNA processing endonuclease, 5644 Fujinamisarcoma virus: Avian RNA tumor virus with a unique Ribosomal protein L7/L12 is required for optimal translation, 4007 transforming gene, 2018 Ribosomal proteins: Expression during Drosophila early development, Homology exists among transforming sequences of avian and feline 5649 sarcoma viruses, 6536 Structures of free and ribosome-bound tRNAPhe: Comparison by using Transforming gene of Fujinami sarcoma virus: Characterization, 3009 slow tritium exchange, 5135 Sarcomavirus, Moloney Ribulosebisphosphate carboxylase (EC 4.1.1.39) Biological activity of cloned Moloney sarcoma virus DNA: Terminally Sizes, locations, and directions of transcription of two genes on a cloned redundant sequences may enhance transformation efficiency, 3504 maize chloroplast DNA sequence, 1832 Integrated Moloney sarcoma proviral DNA sequences: Cloning in Ricin bacteriophage X (correction), 1229 Antibody-directed cytotoxic agents: Use of monoclonal antibody to direct Molecularcloning of unintegratedMoloney mouse sarcomavirus DNA in action of toxin A chains to colorectal carcinoma cells, 4539 bacteriophage X, 1773 Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent Moloney mouse sarcoma virus-specific sequences from uninfected mouse cell-type-specific toxin, 5483 cells: Identification and molecular cloning, 2651 Selective killing of normal or neoplastic B cells by antibodies coupled to Nucleotide sequence analysis of transforming region and large terminal A chain of ricin, 5419 redundanciesof Moloneymurine sarcoma virus, 5234 Rifampicin Nucleotide sequences of integrated Moloney sarcoma provirus long Prokaryotic histone-like protein interacting with RNA polymerase, 3548 terminal repeats and their host and viral junctions, 3937 Ring compound Temperature-sensitive tumorigenicity of cells transformed by mutant of Suggestion for naming faces of ring compounds, 2439 Moloney sarcoma virus, 1501 Sarcomavirus, murine Saccharomycescerevisiae Immunosuppressive factors: In vitro production by murine sarcoma Centromere-linked CDC10 gene: Isolation by complementation in yeast, virus-transformed mouse fibroblasts, 2205 2173 Mapping of transforming region of Harvey murine sarcoma virus genome Codon recognition rules in yeast mitochondria, 3167 by using insertion-deletion mutants constructed in vitro, 4674 Eukaryotic DNA segments capable of autonomous replication in yeast, Transforming growth factors: Isolation of polypeptides from virally and 4559 chemically transformed cells by acid/ethanol extraction, 3494 Extrachromosomal genetic elements: Preferential inclusion in yeast Sarcomavirus, Rous meiotic spores, 5380 Active proliferationof Rous sarcomavirus-infected, but not normal, Fatty acid-requiring mutant of Saccharomyces cerevisiae defective in chicken heart mesenchymal cells in culture medium of physiological acetyl-CoA carboxylase, 1814 composition,6606 Gene for actin in Saccharomyces cerevisiae: Isolation and sequence, 3912 Adhesion plaques of Rous sarcoma virus-transformed cells contain the Gene for iso-2-cytochrome c in Saccharomyces cerevisiae: Isolation and src gene product,3514 sequence, 541 Ascorbic acid inhibits replication and infectivity of avian RNA tumor Isolation of genes by complementation in yeast: Molecular cloning of a virus, 2711 cell-cycle gene, 2119 Associationof the src gene productof Rous sarcomavirus with Mitotic recombination in yeast: Induction by starvation for thymine cytoskeletal structures of chicken embryo fibroblasts, 3484 nucleotides, 6057 Cytoskeletal proteins vinculin and a-actinin: Altered distributions in N,N'-Dicyclohexylcarbodiimide binds specifically to a single glutamyl culturedfibroblasts transformed by Rous sarcomavirus, 6687 residue of the proteolipid subunit of mitochondrial Differences in intracellular location of pp60src in rat and chicken cells adenosinetriphosphatases from Neurospora crassa and Saccharomyces transformed by Rous sarcoma virus, 4142 cerevisiae, 785 Homologyexists amongtransforming sequences of avian and feline Replicator regions of yeast mitochondrial DNA responsible for sarcomaviruses, 6536 suppressiveness, 3942 Mitochondria: Localization in living cells with rhodamine 123, 990 Saccharomyces cerevisiae: Autonomously replicating sequences, 6329 Recombinants between avian sarcoma virus genome and chicken helper factorgene of host cell: Cloningby transfection,3014 Downloaded by guest on September 29, 2021 7600 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Relationship of polypeptide products of the transforming gene of Rous Calcium current modulation underlying presynaptic facilitation and sarcoma virus and the homologous gene of vertebrates, 2059 behavioral sensitization in Aplysia: Mechanism, 6912 Transforming gene product of Rous sarcoma virus phosphorylates Lipid fluidity markedly modulates binding of serotonin to mouse brain tyrosine, 1311 membranes, 7463 Sarcoplasmicreticulum Serotonin-induced hyperpolarization of an identified Aplysia neuron is Calciumtranslocation mechanism in sarcoplasmicreticulum vesicles, mediated by cyclic AMP, 5013 deduced from location studies of protein-bound spin labels, 2405 Serratia marcescens Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned DNA sequence of Serratia marcescens lipoprotein gene, 1369 muscle fibers, 936 Serum Mitochondria and sarcoplasmic reticulum as model targets for neurotoxic see also Growth factor, serum; Plasma and myotoxic phospholipases A2, 1346 Combined glutamine and serum deprivation: Effects on glucose control Quercetin inhibits Ca2+ uptake but not Ca2+ release by sarcoplasmic of hexose transport in mammalian fibroblast cultures, 5958 reticulum in skinned muscle fibers, 4435 Do plasmaand serumhave differentabilities to promotecell growth? Saxitoxin 2726 see also Protein, saxitoxin-binding a-Fetoprotein: Inhibitory effect on binding of myasthenia gravis Saxitoxin-binding component of excitable membrane sodium channel: antibody to acetylcholine receptor, 3635 Purificationfrom rat sarcolemma,1306 Growth of T-lymphoma cells in serum-free medium: Lack of involvement Schiff base of cyclic AMP pathway in long-term cultures, 5993 Exchange kinetics of Schiff base proton in bacteriorhodopsin, 6571 Inability of serum from abetalipoproteinemic subjects to stimulate Protein-methylglyoxal adduct: Spectroscopic studies, 949 proliferation of human smooth muscle cells and dermal fibroblasts in Sciatin vitro, 1511 Myogenesis in vitro: Dependence on a trophic protein present in chicken Insulin and serum increase number of receptors for vasopressin in a embryo extract, 6922 kidney-derived line of cells grown in a defined medium, 5979 Scleroblast Naturally occurring anti-spermine antibody in normal rabbit serum, 2904 Microtubules of cells: Visualization in situ by indirect Schwann cells proliferate but fail to differentiate in defined medium, immunofluorescence, 6657 6902 Scleroderma Sustained growth in primary culture of normal mammary epithelial cells Autoantibody to centromere (kinetochore) in scleroderma sera, 1627 embedded in collagen gels, 2088 Scrapie Serumthymic factor Scrapie agent: Electrophoretic properties in agarose gels, 2984 Serum thymic factor (FTS): Specific receptors in lymphoblastoid Scrapie agent: Replication in ocular neural tissues, 1169 cultured cell lines, 2861 Sea anemone Severe combinedimmunodeficiency disease see Anthopleura elegantissima Immune dysfunction associated with adenosine deaminase deficiency: Sea urchin Animal model, 4899 see also Strongylocentrotus purpuratus Microtubule assembly and concanavalin A capping in lymphocytes: Four sizes of transcript produced by a single sea urchin gene expressed Reappraisal using normal and abnormal human peripheral blood cells, in early embryos, 3259 3499 Messenger RNA prevalence in sea urchin embryos measured with cloned Somatic cell genetics of adenosine deaminase expression and severe cDNAs, 5317 combined immunodeficiency disease in humans, 4211 Secretin Sexual agglutinationfactor Cyclic AMP accumulation in cultured brain cells: Regulation by secretin, Cell-cell recognition in yeast: Purification of Hansenula wingei 21-cell vasoactive intestinal peptide, and somatostatin, 6907 sexual agglutination factor and comparison of factors from three Secretory component genera, 318 Receptor-mediated transcellular transport of immunoglobulin: Synthesis Sexual selection of secretory component as multiple and larger transmembrane forms, Alternative male life histories in bluegill sunfish, 6937 7257 Short-circuitcurrent Seed germination Guinea pig intestinal electrolyte secretion: Control by a b-opiate cis-4-Cyclohexene-1,2-dicarboximide: Inhibitor of receptor, 2753 phytochrome-promoted seed germination, 3408 Sialic acid Selection Correlation between spontaneous metastatic potential, Metabolic resource allocation vs. mating attractiveness: Adaptive platelet-aggregating activity of cell surface extracts, and cell surface pressures on the "alba" polymorphism of Colias butterflies, 3615 sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma Selection limits and strategies, 546 cell line, 4336 Selenium Native polysaccharide antigen of type Ia group B Streptococcus: Selenium-containing tRNAs from Clostridium sticklandii: Structure and serology, 2931 Cochromatography of one species with L-prolyl-tRNA, 1403 Sendai virus utilizes specific sialyloligosaccharides as host cell receptor Self-fertilization determinants, 5693 Self-fertilization and monogenic strains in natural populations of Sialyltransferase terrestrial slugs, 684 see CMP-N-acetylneuraminate-galactosylglycoprotein sialyltransferase Semliki Forest virus Sickle cell disease Capsid protein of Semliki Forest virus has clusters of basic amino acids Antisickling activity of amino acid benzyl esters, 181 and prolines in its amino-terminal region, 6376 Deoxyhemoglobin S polymer: Determination in sickle erythrocytes upon pH-dependent fusion between Semliki Forest virus membrane and deoxygenation, 5487 liposomes, 3273 Effect of cetiedil on erythrocyte sickling: New type of antisickling agent Sendai virus that may affect erythrocyte membranes, 2955 Enhancement of phospholipid transfer from Sendai virus to erythrocytes Kinetics of fiber-to-crystal transition of sickle cell hemoglobin: Electron is mediated by target cell membrane, 804 microscope study, 944 Sendai virus receptor: Proposed recognition structure based on binding Prenatal diagnosis of sickle cell anemia by restriction endonuclease to plastic-adsorbed gangliosides, 1947 analysis: HindIII polymorphisms in y-globin genes extend test Sendai virus utilizes specific sialyloligosaccharides as host cell receptor applicability, 2853 determinants, 5693 Proton longitudinal relaxation investigation of histidyl residues of Transfer of Epstein-Barr virus receptors to receptor-negative cells normal human adult and sickle deoxyhemoglobin: Existence of permits virus penetration and antigen expression, 5453 pregelation aggregates in sickle deoxyhemoglobin solutions, 6577 Senescence,leaf Silicate Abscisic acid content of oat leaves: Changes during senescence, 2050 Sodium-dependent silicate transport in apochlorotic marine diatom Senility Nitzschia alba, 6386 Crystalline ribosomes are present in brains from senile humans, 2260 Silk Serine Sex differences in cooperative silk-spinning by weaver ant larvae, 2343 Protein p3 is linked to DNA of phage k29 through a phosphoester bond Simian virus 40 between serine and 5'-dAMP, 6425 Antibodies specific for carboxy- and amino-terminal regions of simian Receptor structure in bacterial sensing system, 7157 virus 40 large tumor antigen, 5197 Serine-glyoxylate aminotransferase (EC 2.6.1.45) A small RNA induced late in simian virus 40 infection can associate with Photorespiration mutants of Arabidopsis thaliana deficient in early viral mRNAs, 1379 serine-glyoxylate aminotransferase activity, 2684 Cytoplasmic transfer of DNA containing simian virus 40 sequences into Serine protease mouse 3T3 cells, 2844 see also Protease Cytoskeletal F-actin patterns quantitated with fluorescein Covalent structure of human haptoglobin: A serine protease homolog, isothiocyanate-phalloidin in normal and transformed cells, 6624 3388 Deletions covering putative promoter region of early mRNAs of simian Haptoglobin heavy chain: Model based upon structural homology, 3393 virus 40 do not abolish T-antigen expression, 3865 Human factor D: Active site amino acid sequence, 4938 5,6-Dichloro-l-/-ribofuranosylbenzimidazole enhances premature Nerve growth factor: Acceleration of rate of wound healing in mice, 4379 termination of late transcription of simian virus 40 DNA, 3297 Partial amino acid sequence of human factor D: Homology with serine Differential affinities of simian virus 40 large tumor antigen for DNA, proteases, 1116 220 Partial sequence of human complement component factor B: Novel type Direct transfer of cloned genes from bacteria to mammalian cells, 2163 of serine protease, 4923 DNA alkylation and unwinding induced by benzo[a]pyrene diol epoxide: Serotonin. Modulation by ionic strength and superhelicity, 2000 Activation of brain hydroxylase by ATP-Mg2+: Dependence Escherichia coli RNA polymerase in vitro mimics simian virus 40 in vivo on calmodulin, 4688 transcription when the template is viral nucleoprotein, 6556 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7601

Expression of early genes of origin-defective mutants of simian virus 40, Sodium-dependent silicate transport in apochlorotic marine diatom 3898 :' Nitzschia alba, 6386 Fetal rat liver cell line established that retains differentiated liver Specific inhibition of renin by an angiotensinogen analog: Sodium functions, 2731 depletion and renin-dependent hypertension, 5476 Host nuclear proteins expressed in simian virus 40-transformed and Three-dimensional structure of a protein from scorpion venom: New -infectedcells, 97 structural class of neurotoxins, 6496 Indiscriminate recombination in simian virus 40-infected monkey cells, Sodiumdodecyl sulfate 4861 Renaturation and localization of enzymes in polyacrylamide gels: Studies Integration in vivo into simian virus 40 DNA of a sequence that with UDPglucose pyrophosphorylase of Dictyostelium, 730 resembles a certain family of genomic interspersed repeated sequences, Sodium/potassium pump 4514 Abnormal net Na+ and K+ fluxes in erythrocytes of three varieties of Mechanism of interferon action: Simian virus 40-specific early genetically hypertensive rats, 4283 polypeptides synthesized in untreated and interferon-treated monkey Activation of electrogenic Na+/K+ exchange by extracellular K+ in kidney cells, 2419 canine cardiac Purkinje fibers, 4035 Presence of allograft-rejection resistance in simian virus 40-transformed Independence of positive inotropic effect of ouabain from inhibition of hamster cells and its possible role in tumor development, 2886 the heart Na+/K+ pump, 3067 Resistance of simian virus 40-transformed hamster cells to cytolytic Soil effect of activated macrophages: Possible factor in species-specific viral Eyring-Stover survival theory: Application to soil-related functions, 3767 oncogenicity, 6773 Soliton Simian virus 40 and polyoma virus stimulate overall cellular RNA and Open state in long polynucleotide double helices: Possibility of soliton protein synthesis, 1476 excitations, 7222 Simian virus 40 early transcription: Regulation in vitro by a purified Soluble suppressorfactor tumor antigen, 5706 Human soluble suppressor factor affecting lymphocyte responses in Simian virus 40 origins defective in tumor antigen binding and DNA vitro, 6096 replication: Construction and analysis, 6491 Somatomedin Simian virus 40-transformed human fibroblasts: Reversible growth Inhibition of biological activity of multiplication-stimulating activity by arrest, 7306 binding to its carrier protein, 7252 Sindbis virus Multiplication-stimulating activity, an insulin-like growth factor: Virus structural proteins and protein-protein interactions: Distribution Increased levels in fetal rat serum, 3649 in plasma membrane of baby hamster kidney cells infected with Sequential addition of platelet factor and plasma to BALB/c 3T3 Sindbis or vesicular stomatitis virus, 7277 fibroblast cultures stimulates somatomedin-C binding early in cell Sister chromatidexchange cycle, 6644 Antipaininhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced Somatostatin transformation and increases chromosomal aberrations, 6649 see also Preprosomatostatin; Prosomatostatin Cultured mouse embryos metabolize benzo[a]pyrene during early Continuous, clonal, insulin- and somatostatin-secreting cell lines gestation: Genetic differences detectable by sister chromatid exchange, established from a transplantable rat islet cell tumor, 3519 3524 Cyclic AMP accumulation in cultured brain cells: Regulation by secretin, Cytogenetic effects of inhaled benzene in murine bone marrow: vasoactive intestinal peptide, and somatostatin, 6907 Induction of sister chromatid exchanges, chromosomal aberrations, Ovine hypothalamic somatostatin-28 and somatostatin-25: Primary and cellular proliferation inhibition in DBA/2 mice, 2148 structure, 6827 Enhancement of N-methyl-N'-nitro-N-nitrosoguanidine transformation [Phe4]Somatostatin: Potent, selective inhibitor of growth hormone of Syrian hamster cells by a phorbol diester is independent of sister release, 577 chromatid exchanges and chromosome aberrations, 7282 Release of immunoreactive somatostatin from hypothalamic cells in In utero analysis of sister chromatid exchange: Alterations in culture: Inhibition of y-aminobutyric acid, 5552 susceptibility to mutagenic damage as a function of fetal cell type and Somatostatin: An endogenous peptide in toad urinary bladder inhibits gestational age, 4784 vasopressin-stimulated water flow, 4984 Size-frequency distribution Somatostatin-like immunoreactivity in retina, 1691 Competitive intransitivity and size-frequency distributions of interacting Urotensin II: A somatostatin-like peptide in the caudal neurosecretory populations, 5355 system of fishes, 5021 Sleep Somatotropin Impulse activity of locus ceruleus neurons in awake rats and monkeys is see also Gene, somatotropin a function of sensory stimulation and arousal, 3033 factor and of Slow Epidermal growth expression specific genes: Effects on reactingsubstance cultured rat pituitary cells are dissociable from mitogenic response, Leukotriene D: Slow reacting substance from rat basophilic leukemia 394 cells, 2014 [Phe4]Somatostatin: Potent, selective inhibitor of growth hormone Leukotrienes C-1 and D: Comparative airway and vascular activities in release, 577 vivo and in vitro, 4354 Somatotropinrelease-inhibiting factor Mouse peritoneal macrophages release leukotriene C in response to a see Somatostatin phagocytic stimulus, 4928 Sorghumseedling bioassay of Relationship biosynthesis of slow reacting substance to intracellular Mammalian epidermal growth factor promotes plant growth, 4836 glutathione concentrations, 6870 Soybean Slow reacting substances from cat paws: Identification, 5688 see Glycine max Slow reacting substances of anaphylaxis: Identification of leukotrienes Soybeantrypsin inhibitor C-1 and D from human and rat sources, 3710 Camphorquinone-10-sulfonicacid and derivatives:Convenient reagents Slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) for reversible modification of arginine residues, 895 cells: Effect of cysteine on SRS profile, 6481 Spatial frequency Slug Spatial frequency specific interaction of dot patterns and gratings, 662 Self-fertilization and monogenic strains in natural populations of Spatial pattern formation terrestrial 684 slugs, Scale-invariance in reaction-diffusion models of spatial pattern Smittia formation, 4180 Synthesis of a posterior indicator protein in normal embryos and double Spectrin abdomens of Smittia sp. (Chironomidae, Diptera), 6700 Functional domains of human erythrocyte spectrin, 6592 Sociobiology Phosphorylation and dephosphorylation of spectrin from human Gene-culture translation in avoidance of sibling incest, 6248 erythrocyte ghosts under physiological conditions: Autocatalysis rather Translation of epigenetic rules of individual behavior into ethnographic than reaction with separate kinase and 3264 4382 phosphatase, patterns, Proteolytically resistant domains of human erythrocyte spectrin: Sodium Identification, 5673 Binding of sea anemone toxin to receptor sites associated with gating Spermatocyte of sodium system channel in synaptic nerve endings in vitro, 1646 Synaptonemal complexes are premeiotic interphase in mouse Charge movements during Na+/Ca2+ exchange in heart sarcolemmal spermatocyte, 6720 vesicles, 6354 Spermatogenesis Growth in kidney epithelial cells induced in culture by Na+, 6654 Meiotic synthesis of testis histones in rats, 371 Kinetic models suggest bimolecular reaction steps in axonal Na+-channel Quantitation of mRNAs mouse 6582 during spermatogenesis: Protamine-like gating, histone and phosphoglycerate kinase-2 mRNAs increase after meiosis, Protein phosphorylation and sodium conductance in nerve membrane, 6086 812 Sertoli cells contain a mitogenic polypeptide, 4774 Reconstitution of functional membrane-bound acetylcholine receptor Spermatozoa from isolated Torpedo californica receptor protein and electroplax Calmodulin localization in mammalian spermatozoa, 2772 lipids, 1796 Germinal mutation detection in vivo with monospecific antibody against Reversibility of sodium-induced aggregation of sonicated lactate dehydrogenase-X, 7352 phosphatidylserine vesicles, 4026 Mechanism of capacitation: Albumin-mediated changes in plasma Saxitoxin-binding component of excitable membrane sodium channel: membrane lipids during in vitro incubation of rat sperm cells, 1546 Purification from rat sarcolemma, 1306 Spermine Saxitoxin binding protein/Na+ gate of mammalian brain: Molecular Membrane protein lateral mobility: Modulation by polyphosphates and characterization, reconstitution, and "transport-specific fractionation", polyamines, 1457 6884 Naturally occurring anti-spermine antibody in normal rabbit serum, 2904 Single channel currents from excised patches of muscle membrane, 6930 Sphingolipid Sodium and potassium salt stimulation of taste receptor cells: Allosteric Experimental animal model for mucopolysaccharidosis: Suramin-induced model, 1686 glycosaminoglycan and sphingolipid accumulation in rats, 3700 Downloaded by guest on September 29, 2021 7602 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Sphingomyelin Streptococcuspneumoniae Compositionaldomain structure in phosphatidylcholine-cholesteroland Transformationof Streptococcuspneumoniae with S. pneumoniae-X sphingomyelin-cholesterolbilayers, 4055 phage hybridDNA: Inductionof deletions,3534 Hepatic uptake and degradationof unilamellar Streptococcuspyogenes sphingomyelin/cholesterolliposomes: A kinetic study, 4030 /-Galactoside phosphateaccumulation: Regulation in Streptococcus Spinacea oleracea pyogenes by an expulsionmechanism, 5497 Calmodulinfrom spinachleaves and in vitro translationmixtures: Streptococcussanguis Isolationand characterization,1912 Switchesin macromolecularsynthesis duringinduction of competence Spinach for transformationof Streptococcussanguis, 6062 see Spinacea oleracea Streptomycesavidinii Spinal cord Iminobiotinaffinity columnsand their applicationto retrievalof P-Endorphin:Characteristics of bindingsites in rabbit spinal cord, 5746 streptavidin,4666 Largeand persistentelectrical currents enter transectedlamprey spinal Streptozotocin cord, 1209 Insulin-dependentdiabetes mellitus inducedby subdiabetogenicdoses of Largeand persistentelectrical currents enter transectedlamprey spinal streptozotocin:Obligatory role of cell-mediatedautoimmune processes, cord (correction),4390 6129 Spin labeling Strongylocentrotuspurpuratus Calciumtranslocation mechanism in sarcoplasmicreticulum vesicles, Actin gene sequencesin sea urchin:Molecular cloning of an deducedfrom locationstudies of protein-boundspin labels, 2405 intron-containingDNA sequencecoding for a cytoplasmicactin, 5683 Chargeselectivity at lipid-protein interfaceof membranous Cloningof sea urchinactin gene sequencesfor use in studyingregulation Na,K-ATPase,272 of actin gene transcription,765 Enhancementof phospholipidtransfer from Sendai virus to erythrocytes Developmentalshifts in frequencydistribution of polysomalmRNA and is mediatedby target cell membrane,804 their posttranscriptionalregulation in sea urchinembryo, 4653 Reversetranscriptase: Reactivity toward (s4U,U)n copolymers and Leadersequences of Strongylocentrotuspurpuratus histone mRNAs spin-labelednucleic acid lattices, 4574 start at a unique heptanucleotidecommon to all five histone genes, Spleen 1265 see also Cell, spleen Stylonychia mytilus Duringontogeny, Ia-bearing accessory cells are found early in the Aggregationin vitro of gene-sizedDNA moleculesof the ciliate thymus but late in the spleen, 1597 Stylonychia mytilus, 4104 Spleen necrosisvirus Subacutesclerosing panencephalitis No apparentnucleotide sequence specificity in cellularDNA juxtaposed Cloningof DNA complementaryto measlesvirus mRNA encoding to retrovirusproviruses, 7357 nucleocapsidprotein, 3686 Spore Submandibularsalivary gland Endogenouselectrical currents in watermold Blastocladiellaemersonii Nerve growthfactor: Acceleration of rate of woundhealing in mice, 4379 duringgrowth and sporulation,6673 Vasoactiveintestinal polypeptidein cholinergicneurons of exocrine Measurementof internalpH of yeast spores by 31pnuclear magnetic glands:Functional significance of coexistingtransmitters for resonance,2470 vasodilationand secretion,1651 Measurementsof pH within dormantand germinatedbacterial spores, SubstanceP 2474 Nerve growthfactor stimulates development of substanceP in sensory Protein synthesis:Regulation during spore germinationin Dictyostelium ganglia,649 discoideum,1791 SubstanceP enhancescholinergic receptor desensitization in a clonal Squid nervecell line, 634 see Loligopealei Sucrase/isomaltase Staphylococcusaureus Monoclonalantibodies to sucrase/isomaltase:Probes for study of Replicationof plasmidsfrom Staphylococcusaureus in Escherichiacoli, postnataldevelopment and biogenesisof intestinalmicrovillus 7333 membrane,6629 Stereoacuity Sulfate adenylyltransferase(EC 2.7.7.4) Stereoacuityof humaninfants, 5572 Nitrate and sulfate assimilationpathways: Regulatory coupling in Stereochemistry culturedtobacco cells, 6670 Suggestionfor namingfaces of ring compounds,2439 Sulfite dehydrogenase(EC 1.8.2.1) Stereopsis Inbornerrors of molybdenummetabolism: Combined deficiencies of Largeevoked potentials to dynamicrandom-dot correlograms and sulfite oxidaseand xanthinedehydrogenase in a patient lacking stereogramspermit quick determinationof stereopsis,2348 molybdenumcofactor, 3715 Steroid 21-hydroxylase Sulfite oxidase see Steroid 21-monooxygenase see Sulfite dehydrogenase Steroid 21-monooxygenase(EC 1.14.99.10) Sulfur Deoxycorticosteronebiosynthesis in humankidney: Potential for Nitrate and sulfate assimilationpathways: Regulatory coupling in formationof a potent mineralocorticosteroidin its site of action, 7069 culturedtobacco cells, 6670 Steroidogenesis Sulfur dioxide Adrenocorticalresponse to corticotropinis potentiatedby part of Ambientair concentrationof sulfurdioxide affects flight activity in bees, amino-terminalregion of pro-corticotropin/endorphin,2239 5631 Alternativemethod for identifyingreconstituted cells, 381 Superoxideanion Cycloheximide-inducedreversal of adrenocorticotropineffects on Anion channelblockers inhibit lysosomalenzyme secretion from human steroidogenesisand adrenalphospholipids in vivo:Kinetic aspects, neutrophilswithout affecting generation of superoxideanion, 2721 7189 Monocyte-mediatedcytotoxicity: Oxidative mechanisms, 584 Regulationof ornithinedecarboxylase activity by corticotropinin Superoxidedismutase (EC 1.15.1.1) adrenocorticaltumor cell clones:Roles of cyclic AMP and cyclic Free radicalsand inflammation:Superoxide-dependent activation of a AMP-dependentprotein kinase,2767 neutrophilchemotactic factor in plasma,1159 Steroid,sex Genes codingfor sensitivityto interferon(IfRec) and soluble superoxide Sex steroid-bindingprotein of plasma:Immunocytochemical localization dismutase(SOD-1) are linked in mouse and man and map to mouse in tissues of adult monkey Macacanemestrina, 5678 chromosome16, 2168 Steroid sulfatase Superoxidedismutase: Correlation with life-span and specific metabolic see Sterol-sulfatase rate in primatespecies, 2777 Sterol-sulfatase(EC 3.1.6.2) Suramin Expressionof an X-linked gene from an inactivehuman X chromosome Experimentalanimal model for mucopolysaccharidosis:Suramin-induced in mouse-humanhybrid cells: Noninactivationof the steroid sulfatase glycosaminoglycanand sphingolipidaccumulation in rats, 3700 locus in man, 6759 Surfacetension Stimulus-secretioncoupling Small phospholipidvesicles: Internal pressure, surface tension, and Prostaglandinsderived from releaseof arachidonoylresidues as a-result surfacefree enery,4048 of phosphatidylinositolbreakdown: Evidence for a role in Symbiosis stimulus-secretioncoupling, 3292 Ecologicaland evolutionarysignificance of mycorrhizalsymbioses in Stochasticprocess vascularplants (A Review),2113 Averagetime until fixation of a mutant allele in a finite population Synapticterminal undercontinued mutation pressure: Studies by analytical,numerical, Synapticendings and their postsynaptictargets in neostriatum:Synaptic and pseudo-samplingmethods, 522 specializationsrevealed from analysisof serial sections,6926 Density-dependentselection in a randomenvironment: An evolutionary Synaptictransmission process that can maintain stable population dynamics, 7501 Graded synaptic transmission between spiking neurons, 3733 Stomata Lipid fluidity markedly modulates binding of serotonin to mouse brain Abscisicacid content of oat leaves:Changes during senescence, 2050 membranes, 7463 Streptavidin Synaptonemalcomplex Iminobiotin affinity columns and their application to retrieval of Synaptonemal complexes are premeiotic interphase in mouse streptavidin, 4666 spermatocyte, 6720 Streptococcuscremoris Synaptosome Electrochemical proton gradient generated in Streptococcus cremoris by Acetylcholine: Specific stimulated uptake by Torpedo electric organ lactate efflux, 5502 synaptic vesicles, 6234 Streptococcus,group B Binding of sea anemone toxin to receptor sites associated with gating Native polysaccharide antigen of type Ia group B Streptococcus: system of sodium channel in synaptic nerve endings in vitro, 1646 Structure and serology, 2931 Calcium-regulated phosphorylation in synaptosomal cytosol: Dependence on calmodulin, 5812 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7603

Systemiclupus erythematosus Thromboxane Nucleic acid-specific suppressor T cells, 1593 Dissociationof vasoconstrictorand platelet aggregatoryactivities of thromboxaneby carbocyclicthromboxane A2, a stable analogof Taste thromboxane A2, 1706 Sodium and potassiumsalt stimulationof taste receptorcells: Allosteric Thylakoid model, 1686 Supramolecularstructure of stacked and unstackedregions of Taxol photosyntheticmembranes of Prochloronsp., a prokaryote,352 Taxol stabilizesmicrotubules in mouse fibroblastcells, 1561 Thymidine Taxonomy Catecholaminebiosynthetic enzymes are expressedin replicatingcells of Classificationof culturedmammalian cells by shape analysisand pattern peripheralbut not centralnervous system, 6221 recognition,1516 Thymidinekinase Temperature-jumpkinetics Epstein-Barrvirus genes expressedin differentcell types after Proton-coupledconformational switch of Escherichiacoli 5S ribosomal microinjectionof viral DNA, 433 RNA, 3360 Resistanceof herpes simplex virus to acycloguanosine:Role of viral Teosinte thymidinekinase and DNA polymeraseloci, 2270 OrganelleDNA variationand systematicrelationships in genus Zea: Two distinct loci conferresistance to acycloguanosinein herpes simplex Teosinte (correction),1229 virus type 1, 2265 Teratocarcinoma Thymidinekinase (EC 2.7.1.21) DNA-transformedmurine teratocarcinoma cells: Regulationof Activationof early enzymeproduction in small lymphocytesin response expressionof simian virus 40 tumor antigen in stem versus to high, nonmitogenicconcentrations of concanavalinA, 3479 differentiatedcells, 4875 Cloningof active thymidinekinase gene of herpes simplex virus type 1 in Viral thymidinekinase gene and the human/-globin gene introduced Escherichiacoli K-12 (correction),4390 into developmentallymultipotential mouse teratocarcinomacells, 2098 Cotransferof linked eukaryoticgenes and efficient transferof Teratogenesis hypoxanthinephosphoribosyltransferase by DNA-mediatedgene In utero analysisof sister chromatidexchange: Alterations in transfer,1583 susceptibilityto mutagenicdamage as a functionof fetal cell type and Phenotypicevolution of cells resistantto bromodeoxyuridine,4206 gestationalage, 4784 Viralthymidine kinase gene and the human/f-globin gene introduced Termite into developmentallymultipotential mouse teratocarcinomacells, 2098 Evolutionof eusocialityin termites (correction),3070 Thymidylatesynthase (EC 2.1.1.45) Testis Dihydrofolatereductase:thymidylate synthase, a bifunctional Direct inhibitionof testicularfunction by gonadotropin-releasing polypeptidefrom Crithidiafasciculata, 5802 hormone:Mediation by specific gonadotropin-releasinghormone 5-Fluorouracil-methotrexatesynergy: Enhancement of receptorsin interstitialcells, 4459 5-fluorodeoxyuridylatebinding to thymidylatesynthase by Meiotic synthesis of testis histones in rats, 371 dihydropteroylpolyglutamates,5663 Sertoli cells containa mitogenicpolypeptide, 4774 Methotrexate-inducedmisincorporation of uracil into DNA, 1956 Sex steroid-bindingprotein of plasma:Immunocytochemical localization Thymine nucleotide in tissues of adult monkeyMacaca nemestrina,5678 Mitotic recombinationin yeast: Inductionby starvationfor thymine Tetraalaninehapten nucleotides,6057 Effect of cleavinginterchain disulfide bridgeson radiusof gyrationand Thymocyte maximumlength of anti-poly(D-alanyl)antibodies before and after Discrete stages of humanintrathymic differentiation: Analysis of normal reactionwith tetraalaninehapten, 117 thymocytesand leukemiclymphoblasts of T-cell lineage, 1588 Tetracycline Immunosuppressivefactors: In vitro productionby murinesarcoma Tetracycline:Active efflux encodedby four geneticallydifferent virus-transformedmouse fibroblasts,2205 tetracyclineresistance determinants in Escherichiacoli, 3974 Inhibitingthe onset of hormone-induceddesensitization of viable 12-O-Tetradecanoylphorbol13-acetate thymocytes by NO-tosyl-L-lysine chloromethyl ketone, 5967 Local anestheticsinhibit inductionof ornithinedecarboxylase by tumor Peanut agglutininreceptors expressed on virus-inducedpreleukemic cells promoter12-O-tetradecanoylphorbol 13-acetate, 5312 in mice, 2244 Mechanismof skin tumorpromotion: Evidence for severalstages in Thymus promotion,3659 Duringontogeny, Ia-bearing accessory cells are found early in the RibosomalRNA genes in human-mousehybrid cells: Reactivationby thymus but late in the spleen, 1597 12-O-tetradecanoylphorbol13-acetate, 1566 Insulin-dependentdiabetes mellitus inducedby subdiabetogenicdoses of Tetrahydrofolate streptozotocin:Obligatory role of cell-mediatedautoimmune processes, Folate bindingprotein of mitochondriaidentified as dimethylglycine 6129 dehydrogenase,4484 Serum thymic factor (FTS): Specific receptorsin lymphoblastoid Tetrahydrofolatedehydrogenase (EC 1.5.1.3) culturedcell lines, 2861 Cell cycle regulationof dihydrofolatereductase mRNA metabolismin Thyroid mouse fibroblasts,5140 see also Cell, medullarythyroid carcinoma; Cell, thyroid;specific Chinesehamster cell mutants deficient in dihydrofolatereductase hormones activity:Isolation, 4216 Thyroidfollicle Dihydrofolatereductase:thymidylate synthase, a bifunctional Thyrotropinpreparations are mitogenicfor thyroidepithelial cells in polypeptidefrom Crithidiafasciculata, 5802 follicles in suspensionculture, 2743 Initiationof proteinsynthesis in bacteriaat a translationalstart codon of Thyroliberin mammaliancDNA: Effects of the precedingnucleotide sequence, 1442 Ontogeneticpatterns of thyrotropin-releasinghormone-like material in Methotrexatepolyglutamate synthesis by culturedhuman breast cancer rat hypothalamus,pancreas, and retina:Selective effect of light cells, 2919 deprivation,4345 Tetrahymenapyriformis Thyrotropin Evolutionaryorigins of vertebratehormones: Substances similar to DNA sequencescomplementary to mRNAs for a and / subunits of mammalianinsulins are native to unicellulareukaryotes, 6184 thyrotropin:Synthesis, cloning,and identification,3149 Tetraphenylphosphonium Thyrotropinpreparations are mitogenicfor thyroid epithelial cells in Membranepotential changesduring mitogenic stimulation of mouse follicles in suspensionculture, 2743 spleen lymphocytes,2200 Thyrotropin-releasinghormone Thalassemia see Thyroliberin Cloningand direct examinationof a structurallyabnormal human L-Thyroxine /3?-thalassemiaglobin gene, 3558 Affinity labelingof rat liver thyroid hormonenuclear receptor, 7064 Gene deletions in a thalassemiaprove that the 5' 1 locus is functional, Time-lapsecinematography 3586 Cytoplasmicclock with same period as division cycle in Xenopus eggs, Linkage of genes for adult a-globin and embryonic a-like globin chains, 462 1087 Linkage of aG-Philadelphiato a-thalassemia in African-Americans, 4885 Identificationof an N2 line protein of striated muscle, 3254 Processing of human f-globin mRNA precursor to mRNA is' defective in Tobacco three patients with : -thalassemia, 4287 see Nicotiniana tabacum Proportion of hemoglobin G Philadelphia (aO268Asn-LYs2) in Tomato heterozygotes is determined by interaction with a-globin gene see Lycopersicumesculentum deletions, 6874 Torpedocalifornica Triplicated a-globin loci in humans, 518 Acetylcholine:Specific stimulateduptake by Torpedoelectric organ Thermusthermophilus synapticvesicles, 6234 Properties of a copper-containing cytochrome claa3 complex: A terminal Cation translocation by Torpedo acetylcholine receptor: Direct oxidase of the extreme thermophile Thermus thermophilus HB8, 147 spectroscopic studies on a time scale of physiological relevance, 4509 Thermally induced biosynthesis of 2'-O-methylguanosine in tRNA from Reconstitution of functional membrane-bound acetylcholine receptor an extreme thermophile, Thermus thermophilus HB27, 1922 from isolated Torpedo californica receptor protein and electroplax Thioredoxin reductase (NADPH) (EC 1.6.4.5) lipids, 1796 Alloxan: Enzymatic reduction by thioredoxin and NADPH-thioredoxin Reconstitution of purified acetylcholine receptors with functional ion reductase, 5149 channels in planar lipid bilayers, 3057 Thrombin Torpedo acetylcholine receptor subunits as a transmembrane complex: see also Antithrombin; Prothrombin Topographic studies, 5807 Thrombin increases expression of fibronectin antigen on platelet surface, Torpedomarmorata 1049 Collagen-tailed and hydrophobic components of acetylcholinesterase in Torpedo marmorata electric organ, 4464 Downloaded by guest on September 29, 2021 7604 BiologicalSciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Reovirus-induced modification of cap-dependent translation in infected Nucleotide sequence of bacterial transposon Tn1681 encoding a L cells, 152 heat-stable (ST) toxin and its identification in enterotoxigenic Transplantation Escherichia coli strains, 4011 Allogeneic hemopoietic stem cell transplantation using mouse spleen Nucleotide sequence of Moloney leukemia virus: 3' End reveals details of cells fractionated by lectins: In vitro study of cell fractions, 1164 replication, analogy to bacterial transposons, and an unexpected gene, Bovine adrenalchromaffin cells: Prolongedsurvival in rat cerebral 3302- ventricles, 5278 Recombination genes on Escherichia coli sex factor specific for Transport,active transposable elements, 2814 Calcitonin,a majorgill hormone,6935 Regulation of Tn5 transposition in Salmonella typhimurium, 6047 Couplingof active ion transportand aerobicrespiratory rate in isolated Structure of Moloney murine leukemia viral DNA: Nucleotide sequence renal tubules, 447 of the 5' long terminal repeat and adjacent cellular sequences, 3307 Glutathione transport by inside-out vesicles from human erythrocytes, Transposon Tn901 introduced into a plasmid of Anacystis nidulans: 6359 Preparationfor cloningin cyanobacteria,1570 Naphthoquinones restore active transport of solutes and oxidative Trifluoperazine phosphorylationin irradiatedmembrane vesicles from Mycobacterium Calcium-dependent protein kinase: Widespread occurrence in various phlei, 102 tissues and phyla of animal kingdom and comparison of effects of Specific labelingof lac carrierprotein in membranevesicles of phospholipid, calmodulin, and trifluoperazine, 7039 Escherichia coli by'a photoaffinity reagent, 6319 3,3',5-Triiodo-L-thyronine Transport,amino acid Affinity labeling of rat liver thyroid hormone nuclear receptor, 7064 Amino-terminal sequence and processing of precursor of leucine-specific Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured binding protein, and evidence for conformational differences between fibroblasts, 3425 precursor and mature form, 2005 Trimethylpsoralen Calcium-dependenthormonal regulation of amino acid transportand DNA-protein interactions in Drosophila melanogaster mitochondrial cyclic AMP accumulation in rat hepatocyte monolayer cultures, 5953 genome as deduced from trimethylpsoralen crosslinking patterns, 4118 Cloned DNA containing genes responsible for branched-chain amino acid tRNA (adenine-l-)-methyltransferase(EC 2.1.1.36) transportin Escherichiacoli: Structuraland functionalanalysis, 1412 Thermally induced biosynthesis of 2'-O-methylguanosine in tRNA from Colchicine-sensitiveuptake system in Morrishepatomas, 5282 an extreme thermophile, Thermus thermophilus HB27, 1922 Transport,electron tRNA (guanosine-2'-)-methyltransferase(EC 2.1.1.34) see also Electrontransfer Thermally induced biosynthesis of 2'-O-methylguanosine in tRNA from Contrastsbetween oxygenic and anoxygenicphotoreduction of an extreme thermophile, Thermus thermophilus HB27, 1922 ferredoxin:Incompatibilities with prevailingconcepts of Trophectoderm photosyntheticelectron transport, 2676 Monoclonal antibodies against trophectoderm-specific markers during Electrontransport: Inhibition by orthophenanthrolinein mouse blastocyst formation, 4113 chromatophoresarid reaction centers of Rhodopseudomonas Tropomyosin sphaeroides,1809 Cooperativebinding of myosinsubfragment 1 to Electrontransport to nitrogenasein Klebsiella pneumoniae,2555 actin-troponin-tropomyosin complex, 2616 Flash-activatedcyclic electrontransport system constructedby using Cooperative equilibrium binding of myosin subfragment 1 to bacterialreaction centers and ubiquinone-cytochromeb-cl/c segment actin-troponin-tropomyosin complex: Theoretical model, 3186 of mitochondria,6339 Troponin Transport,glucose Can the binding of Ca2+ to two regulatory sites on troponin C determine Coordinate modulation of D-glucose transport activity and bilayer the steep pCa/tension relationship of skeletal muscle? 4717 fluidity in plasmamembranes derived from controland insulin-treated Cooperative binding of myosin subfragment 1 to adipocytes,915 actin-troponin-tropomyosin complex, 2616 Humanerythrocyte glucose transporter: Immunological identification, Cooperative binding of subfragment 1 to regulated actin: Kinetic studies, 5725 7209 Inhibitionof biologicalactivity of multiplication-stimulatingactivity by Cooperative equilibrium binding of myosin subfragment 1 to bindingto its.carrier protein, 7252 actin-troponin-tropomyosin complex: Theoretical model, 3186 Insulin causes translocationof glucosetransport activity to plasma Truncationselection membranefrom an intracellularstorage site, 2542 Selection limits and strategies, 546 Isolationof a Chinesehamster fibroblast mutant defective in hexose Trypanosomabrucei transportand aerobicglycolysis: Its use to dissect the malignant Sequences of two kinetoplast DNA minicircles of Trypanosoma brucei, phenotype,2698 2445 Transport,hexose Trypanosomabrucei brucei Arachidonicacid: Role in stimulationof hexose transportby human Trypanosoma brucei brucei: Inhibition of glycosylation of major variable polymorphonuclearleukocytes, 5125 surface coat glycoprotein by tunicamycin, 1529 Combinedglutamine and serumdeprivation: Effects on glucosecontrol Trypanosomacruzi of hexose transportin mammalianfibroblast cultures, 5958 Trypanosoma cruzi: Strains and clones can be characterized by pattern Transport,ion of restrictionendonuclease products of kinetoplastDNA minicircles, see also Electrontransfer; Proton transfer 6810 Calciumtranslocation mechanism in sarcoplasmicreticulum vesicles, Tryptophan deducedfrom locationstudies of protein-boundspin labels, 2405 Fluorescence energy transfer studies on active site of papain, 940 Cationtranslocation by Torpedoacetylcholine receptor: Direct Tryptophan,5-hydroxy- spectroscopicstudies on a time scale of physiologicalrelevance, 4509 see Serotonin Chloride-activatedpassive potassiumtransport in humanerythrocytes, Tryptophanhydroxylase 1711 see Tryptophan 5-monooxygenase Covalentlabeling of proteincomponents of sodium channelwith a Tryptophan5-monooxygenase (EC 1.14.16.4) photoactivablederivative of scorpiontoxin, 639 Activation of brain tryptophan hydroxylase by ATP-Mg2+: Dependence Guineapig intestinal electrolytesecretion: Control by a b-opiate on calmodulin; 4688 receptor,2753 Tuberculoprotein Ion-transportchain of cytochromeoxidase: The two chain-direct Tuberculoprotein derived from Mycobacterium tuberculosis: couplingprinciple of energycoupling, 6391 Radioimmunoassay, 4301 Lipid phase transitionin planarbilayer membrane and its effect on Tubocurarine carrier-and pore-mediatedion transport,3403 Attempt to distinguish between actions of neuromuscular blocking drugs Mineralocorticoid'target sites: Identificationin isolated rabbitcortical on the acetylcholine receptor and on its associated ionic channel, 5003 nephron,3672 Tubulin Nigericin-stimulatedATPase activity in microsomalvesicles of tobacco Appearance of cytoskeletal components on the surface of leukemia cells callus, 5904 and of lymphocytes transformed by mitogens and Epstein-Barr virus, Phospholipidsas molecularinstruments of ion and solute transportin 4979 biologicalmembranes, 257 Exothermic process associated with in vitro polymerization of brain Rate theory calculationof gramicidinsingle-channel currents using tubulin, 4425 NMR-derivedrate constants,2028 Tumor Transport,protein see also Antigen, tumor; Antigen, tumor cell; specific cells; specific Anti-Thy 1.2 monoclonalantibody linked to ricin is a potent tumors cell-type-specifictoxin, 5483 Alternative method for identifying reconstituted cells, 381 Fast axonaltransport in auditoryneurons of guinea pig: A rapidly Chromophore and apo-protein: Roles in neocarzinostatin action, 1970 turned-overglycoprotein, 3042 Continuous, clonal, insulin- and somatostatin-secreting cell lines Vesicular stomatitis virus glycoprotein: Transport in a cell-free extract, establishedfrom a transplantablerat islet cell tumor,3519 3870 Correlation of patterns of anchorage-independent growth with in vivo Transport, purine nucleoside 'behavior of cells from a murine fibrosarcoma, 1039 Stimulatory effect of low ATP pools on transport of purine nucleosides Diethyldithiocarbamate rescue: Effect on tumor response to cis-platinum in cells of Escherichia coli, 2519 in a rat model, 5441 Transport, sugar Enhanced drug-metabolizing capacity within liver adjacent to human /-Galactoside phosphate accumulation: Regulation in Streptococcus and rat liver tumors, 600 pyogenes by an expulsion mechanism, 5497 5-Fluorouracil-methotrexate synergy: Enhancement of Transposon 5-fluorodeoxyuridylate binding to thymidylate synthase by Gene expression: Control by a mobile recombinational switch, 4880 dihydropteroylpolyglutamates, 5663 Kanamycin resistance transposon Tn903: Genetic and DNA sequence Heparan sulfate-containing proteoglycan isolated from basement analysis, 7176 membrane,4494 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7605

Functional acetylcholine receptor from Torpedo marmorata in planar Amplificationof integratedviral DNA sequencesin polyoma membranes, 3052 virus-transformed cells, 3850 Membrane-bound acetylcholine receptor from Torpedo marmorata: Appearance of cytoskeletal components on the surface of leukemia cells Structural details, 952 and of lymphocytestransformed by mitogensand Epstein-Barrvirus, Torpedoocellata 4979 Activation, inactivation, and desensitization of acetylcholine receptor Ascorbic acid inhibits replication and infectivity of avian RNA tumor channel complex detected by binding of perhydrohistrionicotoxin, 2309 virus, 2711 NO-Tosyl-L-lysinechloromethyl ketone Association of the src gene product of Rous sarcoma virus with Inhibiting the onset of hormone-induced desensitization of viable cytoskeletal structures of chicken embryo fibroblasts, 3484 thymocytes by N -tosyl-L-lysine chloromethyl ketone, 5967 Cellular genes: Activation by avian RNA tumor viruses, 5351 Toxin Coding capacity of a 35% fragment of polyoma virus genome is sufficient see also Venom; specific toxins to initiate and maintaincellular transformation, 3278 Toxin A Comparative tryptic peptide mapping studies suggest a role in cell Pseudomonas aeruginosa mutant producing a nontoxic, immunologically transformationfor gag-relatedprotein of avian erythroblastosisvirus crossreactive toxin A protein: Isolation and characterization, 7199 and avian myelocytomatosisvirus strains CMII and MC29,1637 Toxin, cholera Cytoplasmic transfer of DNA containing simian virus 40 sequences into Naturallysoluble component(s)that confer(s)guanine nucleotide and mouse 3T3 cells, 2844 fluoride sensitivity to adenylate" cyclase, 3836 Cytoskeletal F-actin patterns quantitated with fluorescein Sustainedgrowth in primaryculture of normalmammary epithelial cells isothiocyanate-phalloidinin normaland transformedcells, 6624 embeddedin collagengels, 2088 Cytoskeletal proteins vinculin and a-actinin: Altered distributions in Toxin, diphtheria cultured fibroblasts transformed by Rous sarcoma virus, 6687 Antibody-directedcytotoxic agents:Use of monoclonalantibody to direct Differences in intracellular location of pp60Osrin rat and chicken cells action of toxin A chains to colorectal carcinoma cells, 4539 transformed by Rous sarcoma virus, 4142 Diphtheria toxin: Binding to phospholipids in liposomes, 1986 DNA crosslinking and cytotoxicity in normal and transformed human Diphtheriatoxin: Nucleotidebinding and toxin heterogeneity,267 cells treated with antitumor nitrosoureas, 467 Posttranslationalmodification of elongationfactor 2 in DNA crosslinkingand cytotoxicityin normaland transformedhuman diphtheria-toxin-resistant mutants of CHO-K1 cells, 1010 cells treated with antitumor nitrosoureas (correction), 1721 Vimentin filament organization in monkey kidney CV-1 cells: Specific Fetal rat liver cell line established that retains differentiated liver disruptionby diphtheriatoxin, exotoxin A, and cycloheximide,7267 functions, 2731 Toxin, Escherichiacoli heat-stable Fujinami sarcoma virus: Avian RNA tumor virus with a unique Nucleotide sequence of bacterial transposon Tn1681 encoding a transforming gene, 2018 heat-stable (ST) toxin and its identification in enterotoxigenic Generationof oncogenicmouse type C virus:In vitro selection of Escherichia coli strains, 4011 carcinoma-inducingvariants, 624 Toxin, scorpion Helper virus is not required for in vitro erythroid transformation of Covalentlabeling of protein componentsof sodium channelwith a hematopoietic cells by Friend virus, 5287 photoactivablederivative of scorpiontoxin, 639 Hepatitis B surface antigen particles excreted from mouse cells Transcription transformed with cloned viral DNA, 4549 Cell-freecoupled transcription-translation system for investigationof Homologyexists amongtransforming sequences of avian and feline linearDNA segments,7029 sarcomaviruses, 6536 Conalbumin gene: Specific in vitro transcription is drastically decreased Host nuclearproteins expressed in simian virus 40-transformedand by single-point mutation in T-A-T-A box homology sequence, 7024 -infected cells, 97 DNA-dependenttranscription of adenovirusgenes in a soluble whole-cell Immunosuppressive factors: In vitro production by murine sarcoma extract,3855 virus-transformed mouse fibroblasts, 2205 Escherichia coli RNA polymerase in vitro mimics simian virus 40 in vivo Mapping of transforming region of Harvey murine sarcoma virus genome transcription when the template is viral nucleoprotein, 6556 by using insertion-deletion mutants constructed in vitro, 4674 L factor required for /-galactosidase synthesis is the nusA gene product Methylation of integrated adenovirus type 12 DNA sequences in involved in transcription termination, 1991 transformedcells is inverselycorrelated with viral gene expression,253 Native ribonucleoproteinis an efficient transcriptionalcomplex of avian Monoclonalantibodies against majorglycoprotein (gp350/220) of myeloblastosisvirus, 1296 Epstein-Barrvirus neutralizeinfectivity, 5307 Promoterfor establishmentof repressorsynthesis in bacteriophageX, Mutant of avian erythroblastosisvirus defective for erythroblast 3191 transformation: 'Deletion in erb portion of p75 suggests function of the Quantitationof mRNAs duringmouse spermatogenesis:Protamine-like protein in leukemogenesis, 6683 histone and phosphoglyceratekinase-2 mRNAs increaseafter meiosis, Predicted structure of two adenovirus tumor antigens, 3778 6086 Presenceof allograft-rejectionresistance in simian virus 40-transformed Regulationof early adenovirustranscription: A protein productof early hamster cells and its possible role in tumor development, 2886 region 2 specifically represses region 4 transcription, 1893 Protein encoded by transforming gene of avian sarcoma virus (pp6src) Simian virus 40 early transcription: Regulation in vitro by a purified and a homologous protein in normal cells (pp60roto-src) are associated tumor antigen, 5706 with plasmamembrane, 3783 Specifictranscription factor that can bind either the 5S RNA gene or 5S Relationship of polypeptide products of the transforming gene of Rous RNA, 4170 sarcoma virus and the homolQgous gene of vertebrates, 2059 Transcription in vitro of normal, mutant, and truncated mouse a- globin Resistance of simian virus 40-transformed hamster cells to cytolytic genes, 7132 effect of activated macrophages: Possible factor in species-specific viral Two control regions for eukaryotic tRNA gene transcription, 3365 oncogenicity, 6773 Transepithelial migration Simian virus 40-transformed human fibroblasts: Reversible growth Transepithelialmigration of humanneutrophils: An in vitro model arrest,7306 system, 4069 Target cell specificity of defective avian leukemia virus: Hematopoietic Transepithelial migration of human neutrophils: An in vitro model target cells for a given virus type can be infected but not transformed system (correction), 6941 by strains of a different type, 389 Transepithelial potential difference Temperature-sensitive tumorigenicity of cells transformed by mutant of Guinea pig intestinal electrolyte secretion: Control by a b-opiate Moloneysarcoma virus, 1501 receptor, 2753 Transformation-defective mutant of Abelson murine leukemia virus Transfection lacks protein kinase activity, 4993 Recombinants between avian sarcoma virus genome and chicken helper Transformation of rat embryo fibroblasts by cloned polyoma virus DNA factor gene of host cell: Cloning by transfection, 3014 fragments containing only part of the early region, 3978 Transformation-relatedantigens identified by monoclonalantibodies, Fetal rat liver cell line established that retains differentiated liver 3234 functions, 2731 Transforming gene of Fujinami sarcoma virus: Characterization, 3009 Transformation of cells, chemical Transforming growth factors: Isolation of polypeptides from virally and Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced chemically transformed cells by acid/ethanol extraction, 3494 transformation and increases chromosomal aberrations, 6649 Tumorigenic transformation induced by specific fragment of DNA from Appearance of cytoskeletal components on the surface of leukemia cells herpes simplex virus type 2, 2279 and of lymphocytestransformed by mitogensand Epstein-Barrvirus, Two tumor antigens and their polypeptides in adenovirus type 4979 12-infected and transformed cells, 2274 Cycle-related toxicity and transformation in 1OT1/2 cells treated with Variations in properties of virus released from morphologically different N-methyl-N'-nitro-N-nitrosoguanidine, 4813 cell lines transformed in vitro by Friend leukemia virus, 5769 Enhancement of N-methyl-N'-nitro-N-nitrosoguanidine transformation Viral DNA sequencesin hamstercells transformedby herpes simplex of Syrian hamster cells by a phorbol diester is independent of sister virus type 2, 880 chromatid exchanges and chromosome aberrations, 7282 Y73, an avian sarcoma virus: A unique transforming gene and its Molecular genetics of carcinogenesis in rats: Model, 3450 product, a phosphopolyprotein with protein kinase activity, 6199 Transformation of cultured C3H/10T1'/2 mouse embryo fibroblasts by Transglutaminase 3-methylcholanthrene: Probabilistic view, 7272 see Glutaminyl-peptide -y-glutamyltransferase Transforming growth factors: Isolation of polypeptides from virally and y-Glutamylamine cyclotransferase: Specificity toward chemically transformed cells by acid/ethanol extraction, 3494 e-(L-y-glutamyl)-L-lysine and related compounds, 4564 Transformation of cells, radiation' Regulationof insulin receptors:Evidence for involvementof an Relationship between x-ray exposure and malignant transformation in endocytoticinternalization pathway, 5975 C3H 1OT1/2 cells, 7262 Translation ' Transformation of cells, viral Inhibitionof initiationof translationby a factor isolated from Adhesion plaques of Rous sarcoma virus-transformed cells contain the Escherichia coli cells, 1181 src gene product, 3514 Downloaded by guest on September 29, 2021 7606 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Highly efficient induction of type C retroviruses by a human tumor in Genetic control of number of midbrain dopaminergic neurons in inbred athymic mice, 2247 strains of mice: Relationship to size and neuronal density of the Immunosuppressive factors: In vitro production by murine sarcoma striatum, 4369 virus-transformed mouse fibroblasts, 2205 Tyrosine hydroxylase: Substrate of cyclic AMP-dependent protein Improving the anti-tumor activity of 5-fluorouracil by increasing its kinase, 92 incorporation into RNA via metabolic modulation, 4966 Integrated and free viral DNA in hamster tumors induced by BK virus, Ubiquinol-cytochromec reductase(EC 1.10.2.2) 975 Crystallization of middle part of mitochondrial electron transfer chain: Liver tumors distinguished by immunofluorescence microscopy with Cytochrome bcl-cytochrome c complex, 5084 antibodies to proteins of intermediate-sized filaments, 4948 Ubiquinone Membrane-active drugs potentiate killing of tumor cells by Electron transport: Inhibition by orthophenanthroline in D-glucosamine, 1172 chromatophores and reaction centers of Rhodopseudomonas Natural cytotoxic cells against solid tumors in mice: Blocking of sphaeroides, 1809 cytotoxicity by D-mannose, 2895 Flash-activated cyclic electron transport system constructed by Sensitive using assay for plasminogen activator of transformed cells, 3796 bacterial reaction centers and ubiquinone-cytochrome b-cl/c segment Temperature-sensitive tumorigenicity of cells transformed by mutant of of mitochondria, 6339 Moloney sarcoma virus, 1501 UDPglucosepyrophosphorylase Tumor growth in animals controlled by infusion of an angiogenesis see Glucose-l-phosphate uridylyltransferase inhibitor, 4331 Ulex europaeus Tumor rejection: Suppression by autologous anti-idiotypic immunity, Differential lectin binding to cellular membranes in epidermis of 2209 newborn rats, 477 Tumorantigen Uracil see Antigen, tumor Methotrexate-induced misincorporation of uracil into DNA, 1956 Tumorigenesis Uracil,5-fluoro- Isolation of a Chinese hamster fibroblast mutant defective in hexose 5-Fluorouracil-methotrexate synergy: Enhancement of transport and aerobic glycolysis: Its use to dissect the malignant 5-fluorodeoxyuridylate binding to thymidylate synthase by phenotype, 2698 dihydropteroylpolyglutamates, 5663 Polyoma large tumor antigen is not required for tumorigenesis mediated Improving the anti-tumor activity of 5-fluorouracil by increasing its by viral DNA, 1336 incorporation into RNA via metabolic modulation, 4966 Tumorimmunity Urea Presence of allograft-rejection resistance in simian virus 40-transformed Renaturation and localization of enzymes in polyacrylamide gels: Studies hamster cells and its possible role in tumor development, 2886 with UDPglucose pyrophosphorylase of Dictyostelium, 730 T-T hybridoma product specifically suppresses tumor immunity, 2866 Urea, chloroethylnitroso- Tumor promoter DNA crosslinking and cytotoxicity in normal and transformed human Local anesthetics inhibit induction of ornithine decarboxylase by tumor cells treated with antitumor nitrosoureas, 467 promoter 12-0-tetradecanoylphorbol 13-acetate, 5312 DNA crosslinking and cytotoxicity in normal and transformed human Mechanism of skin tumor promotion: Evidence for several stages in cells treated with antitumor nitrosoureas (correction), 1721 promotion, 3659 Urea, ethylnitroso- Phorbol esters induce differentiation in human malignant T Effect of introduction of small alkyl groups on mRNA function, 1983 lymphoblasts, 2964 Uridine Phorbol ester tumor promoters: Specific binding, 567 see also Deoxyuridine, 5-bromo- Ribosomal RNA genes in human-mouse hybrid cells: Reactivation by : Reactivity toward (s4U,U)n copolymers and 12-0-tetradecanoylphorbol 13-acetate, 1566 spin-labeled nucleic acid lattices, 4574 Tumor promoters enhance myeloid and erythroid colony formation by Urinarybladder normal mouse hemopoietic cells, 4152 Glyoxylate cycle in toad urinary bladder: Possible stimulation by Tumor virus aldosterone, 1521 see also specific viruses Somatostatin: An endogenous peptide in toad urinary bladder inhibits Humans have antibodies capable of recognizing oncoviral glycoproteins: vasopressin-stimulated water flow, 4984 Demonstration that these antibodies are formed in response to cellular Urine modification of glycoproteins rather than as consequence of exposure (R)-Mevalonate excretion in human and rat urines, 5738 to virus, 1617 Urinary and brain /-carboline-3-carboxylates as potent inhibitors of Malignancies of metastatic murine lymphosarcoma cell lines and clones brain benzodiazepine receptors, 2288 correlate with decreased cell surface display of RNA tumor virus UroporphyrinogenI synthase (EC 4.3.1.8) envelope glycoprotein gp70, 5943 Rare structural variants of human and murine uroporphyrinogen I Mutant and recombinant avian retroviruses with extended host range, synthase, 2848 536 UrotensinII Specificity of human antibodies to oncovirus glycoproteins: Recognition Urotensin II: A somatostatin-like peptide in the caudal neurosecretory of antigen by natural antibodies directed against carbohydrate system of fishes, 5021 structures, 1622 Uterus Tunicamycin Progesterone inhibition of uterine nuclear estrogen receptor: Dependence Carbohydrate requirement for expression and stability of acetylcholine on RNA and protein synthesis, 5856 receptor on surface of embryonic muscle cells in culture, 5263 Differentiation of human and murine myeloid leukemia cells induced in Valine culture by tunicamycin, 409 Multivalent translational control of transcription termination at Trypanosoma brucei brucei: Inhibition of glycosylation of major variable attenuator of ilvGEDA operon of Escherichia coli K-12, 1862 surface coat glycoprotein by tunicamycin, 1529 Nucleotide sequence of ilvGEDA operon attenuator region of Turbatrixaceti Escherichia coli, 1823 Altered enolase in aged Turbatrix aceti results from conformational Vanadate changes in the enzyme, 5865 Vanadate inhibition of auxin-enhanced H+ secretion and elongation in Turing'smodel pea epicotyls and oat coleoptiles, 7242 Scale-invariance in reaction-diffusion models of spatial pattern Vascularplant formation, 4180 Ecological and evolutionary significance of mycorrhizal symbioses in Type C virus vascular plants (A Review), 2113 Generation of oncogenic mouse type C virus: In vitro selection of Vasoactiveintestinal polypeptide carcinoma-inducing variants, 624 Cyclic AMP accumulation in cultured brain cells: Regulation by secretin, Highly efficient induction of type C retroviruses by a human tumor in vasoactive intestinal peptide, and somatostatin, 6907 athymic mice, 2247 Vasoactive intestinal polypeptide in cholinergic neurons of exocrine Type C retrovirus particles: Detection and isolation from fresh and glands: Functional significance of coexisting transmitters for cultured lymphocytes of a patient with cutaneous T-cell lymphoma, vasodilation and secretion, 1651 7415 Vasoconstrictor L-Tyrosine Dissociation of vasoconstrictor and platelet aggregatory activities of Arogenate (pretyrosine) is an obligatory intermediate of L-tyrosine thromboxane by carbocyclic thromboxane A2, a stable analog of biosynthesis: Confirmation in a microbial mutant, 1270 thromboxane A2, 1706 Cord-blood tyrosine levels in full-term phenylketonuric fetus and the Vasodilation "justification hypothesis", 6175 Hypotensive action of parathyroid hormone preparations on rats and Transforming gene product of Rous sarcoma virus phosphorylates dogs, 675 tyrosine, 1311 Vasopressin Tyrosine administration increases striatal dopamine release in rats with see also Receptor, vasopressin partial nigrostriatal lesions, 4305 Immunological identification of high molecular weight forms common to Tyrosine aminotransferase (EC 2.6.1.5) bovine neurophysin and vasopressin, 2587 Unique long-acting antiglucocorticoid in whole and broken cell systems, Somatostatin: An endogenous peptide in toad urinary bladder inhibits 5167 vasopressin-stimulated water flow, 4984 Tyrosine hydroxylase Venom see Tyrosine 3-monooxygenase see also Toxin Tyrosine 3-monooxygenase (EC 1.14.16.2) Venom,cobra Catecholamine biosynthetic enzymes are expressed in replicating cells of Three-dimensional structure of the "long" neurotoxin from cobra venom, peripheral but not central nervous system, 6221 2400 Downloaded by guest on September 29, 2021 Proc. Natl. Acad. Sci. USA 77 (1980) Biological Sciences Subject Index 7607

Venom,scorpion Receptor-like protein for 1,25-dihydroxyvitamin D3 in rat skin: Three-dimensionalstructure of a proteinfrom scorpionvenom: New Characterization, 5822 structuralclass of neurotoxins,6496 VitaminK Vesicle, coated Radioimmunoassay for vitamin K-dependent protein of bone and its Brain clathrin:Immunofluorescent patterns in culturedcells and tissues, discovery in plasma, 2234 5520 Vitellogenin Coatedpits act as molecularfilters, 4156 Coordinateregulation of two estrogen-dependentgenes in avian liver, Coatedvesicles transportnewly synthesizedmembrane glycoproteins 4474 from endoplasmicreticulum to plasma membranein two successive Isolation of two closely related vitellogenin genes, including their stages, 780 flanking regions, from a Xenopus laevis gene library, 1437 Vesicle, microsomal Vitreoushumor Nigericin-stimulatedATPase activity in microsomalvesicles of tobacco Lentropin: A factor in vitreous humor which promotes lens fiber cell callus, 5904 differentiation, 490 Vesicularstomatitis virus Voltageclamp Coatedvesicles transportnewly synthesizedmembrane glycoproteins Activation of electrogenic Na+/K+ exchange by extracellular K+ in from endoplasmicreticulum to plasmamembrane in two successive canine cardiacPurkinje fibers, 4035 stages, 780 Currentrecorded from a cut-open giant axon under voltage clamp,7484 Conformationof helical nucleocapsidsof paramyxovirusesand vesicular Presynaptic inhibition in Aplysia involves a decrease in the Ca2+ current stomatitisvirus: Reversible coiling and uncoilinginduced by changes of the presynapticneuron, 1185 in salt concentration,2631 Presynaptic membrane potential affects transmitter release in an Interferon-treatedcells releasevesicular stomatitis virus particleslacking identified neuron in Aplysia by modulating Ca2+ and K+ currents, 629 glycoproteinspikes: Correlation with biochemicaldata, 2284 Volvoxcapensis Kinetics of decay in expressionof interferon-dependentmRNAs L-Glutamicacid as a mediatorof sexual morphogenesisin Volvox responsiblefor resistanceto virus,452 capensis, 1025 Polycistronicvesicular stomatitis virus RNA transcripts,4662 von Willebranddisease Purificationof a factorthat restorestranslation of vesicularstomatitis Factor VIII antigen in von Willebrand disease: Structural analysis, 6832 virus mRNA in extractsfrom poliovirus-infectedHeLa cells, 770 Synthesis in vitro of full-lengthcomplement of negative-strandgenome Water RNA of vesicularstomatitis virus, 294 CarboxypeptidaseA, in supercooledwater: Structure and function, 132 Synthesis in vitro of full-lengthcomplement of defective-interfering Conformationalchanges during enzyme catalysis:Role of water in the particleRNA of vesicularstomatitis virus, 3927 transition state, 3374 Vesicularstomatitis virus glycoprotein:Transport in a cell-freeextract, Woundhealing 3870 Cell density determines epithelial migration in culture, 4760 Vesicularstomatitis virus glycoproteinis anchoredin viral membraneby Nerve growthfactor: Acceleration of rate of wound healing in mice, 4379 a hydrophobicdomain near the COOHterminus, 3884 Wounding Virus structuralproteins and protein-proteininteractions: Distribution Auxin-induced changes in patterns of protein synthesis in soybean in plasmamembrane of baby hamsterkidney cells infected with hypocotyl, 357 Sindbis or vesicularstomatitis virus, 7277 Vibrissae dehydrogenase(EC 1.2.1.37) Cytochromeoxidase of corticalbarrels: Histochemical changes after Inbornerrors of molybdenummetabolism: Combined deficiencies of vibrissalremoval in neonataland adult mice, 2333 sulfite oxidaseand xanthine dehydrogenasein a patient lacking Vigna radiata molybdenumcofactor, 3715 Protein bodies of mung bean cotyledonsas autophagicorganelles, 428 Xenopus laevis Villin see also Oocyte, Xenopus laevis Calciumcontrol of intestinal microvilluscytoskeleton: Implications for Cloningof an origin of DNA replicationof Xenopus laevis, 5292 regulationof microfilamentorganizations, 6458 Isolation of two closely related vitellogenin genes, including their Vimentin flanking regions, from a Xenopus laevis gene library, 1437 Liver tumorsdistinguished by immunofluorescencemicroscopy with Xerodermapigmentosum antibodiesto proteinsof intermediate-sizedfilaments, 4948 Error-freeexcision of cytotoxic,mutagenic N2-deoxyguanosine DNA Vimentinfilament organization in monkeykidney CV-1 cells: Specific adduct formed in human fibroblasts by disruptionby diphtheriatoxin, exotoxinA, and cycloheximide,7267 (+)-7P,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzota]pyrene, Vinblastine 5933 Colchicine-sensitiveuptake system in Morrishepatomas, 5282 X-ray crystallography Vinculin see also Protein crystallography Cytoskeletalproteins vinculin and a-actinin:Altered distributions in Carboxypeptidase A mechanisms, 3875 culturedfibroblasts transformed by Rous sarcomavirus, 6687 Electron micrographs of negatively stained protein molecules: Fidelity of Vinculin,an intracellularprotein localized at specializedsites where structure representation, 4721 microfilamentbundles terminateat cell membranes,4127 Potato inhibitorcomplex of carboxypeptidaseA: Structureat 2.5-A Virginiamycm resolution, 4633 Lastingdamage to bacterialribosomes by reversiblybound virginiamycin Three-dimensional crystals of membrane proteins: Bacteriorhodopsin, M, 5492 1283 Viroid Three-dimensional structure of the "long" neurotoxin from cobra venom, see specific viroids 2400 Virus White lines in L-edge x-ray absorption spectra and their implications for see specific viruses;see also Defective interferingparticle anomalousdiffraction studies of biologicalmaterials, 5884 Visna virus X-ray diffraction Genomicchanges associated with antigenicvariation of visna virus Body-centered cubic phase of lipid systems: Structure, 6991 duringpersistent infection, 4454 Carboxybiotintranslocation mechanisms suggested by diffractionstudies Visual adaptation of biotin and its vitamers, 333 Light adaptationand temperatureeffects in rat PIII retinal response: Molecular structure and intermolecular interactions of Analysiswith a two-state model, 4021 Nl'-methoxycarbonylbiotin methyl ester: Model for carboxybiotin, Visual evoked potential 1260 Bicucullineenhances a negativecomponent and diminishesa positive Molecularstructure of anticancerdrug-DNA complex:Daunomycin plus componentof visual evoked corticalpotential in cats, 7476 d(CpGpTpApCpG),7204 Visual perception Pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate Spatial frequencyspecific interactionof dot patterns and gratings,662 aminotransferase: Three-dimensional structure, 2559 Stereoacuityof humaninfants, 5572 Redox conformationchanges in refined tuna cytochromec, 6371 VitaminA Structure of an actively exchanging complex between carboxypeptidase see also Retinoic acid A and a substrate analogue, 3288 Polyamineand differentiation:Induction of ornithinedecarboxylase by Tetramerd(CpGpCpG) crystallizes as a left-handeddouble helix, 4016 parathyroidhormone is a good markerof differentiatedchondrocytes, X-ray structure of a cytidylyl-3',5'-adenosine-proflavine complex: A 1481 self-paired parallel-chain double helical dimer with an intercalated VitaminB-12 acridinedye, 1852 see Cobalamin X-ray scattering VitaminC Effect of cleaving interchain disulfide bridges on radius of gyration and see Ascorbicacid maximumlength of anti-poly(D-alanyl)antibodies before and after VitaminD reaction with tetraalanine hapten, 117 Bone resorptionand calciumconservation during vitamin D deficiencyor Stopped-flow x-ray scattering: Dissociation of aspartate hypervitaminosisD: Direct measurement,1818 transcarbamylase, 4040 Cellular and subcellular localization of 1,25-(OH)2-vitamin D3 in rat kidney:Comparison with localizationof parathyroidhormone and Yeast estradiol,1149 see Hansenula polymorpha; Hansenula wingei; Pichia pastoris; la,25-Dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol: In Saccharomyces cerevisiae vitro synthesis by isolated calvarial cells, 5720 Kidney tissue: Role in production of 25-hydroxyvitamin D3-26,23-lactone Zea and laQ,25-dihydroxyvitamin D3-26,23-lactone, 6411 Organelle DNA variation and systematic relationships in genus Zea: Metabolism of 25-hydroxyvitamin D3 in vitro by isolated rat kidney Teosinte (correction), 1229 cells, 1537 Zea mays see also Maize Downloaded by guest on September 29, 2021 7608 Biological Sciences Subject Index Proc. Natl. Acad. Sci. USA 77 (1980)

Cloned maize chloroplast DNA sequences: Preferential transcription by Zonapellucida maize chloroplast RNA polymerase, 822 Zonapellucida proteins: Synthesis by denudedand follicle-enclosed Duplicated cytosolic malate dehydrogenase genes in Zea mays, 4866 mouse oocytesduring culture in vitro, 1029 Nuclear and cytoplasmic genes controlling synthesis of variant Zooplankton mitochondrial polypeptides in male-sterile maize, 418 Populationoscillations and energyreserves in planktoniccladocera and Sizes, locations, and directions of transcription of two genes on a cloned their consequencesto competition,1716 maize chloroplast DNA sequence, 1832 Zymosan Zein Mouseperitoneal macrophages release leukotriene C in responseto a Electron spin resonance of 170-labeled protein-peroxide radicals: Zein phagocyticstimulus, 4928 and edestin, 343 Prostaglandinsynthesis by macrophagesrequires a specific Zinc receptor-ligandinteraction, 4279 Ligand substitution reaction of metallothioneins with EDTA and apo-carbonic anhydrase, 6334 Downloaded by guest on September 29, 2021