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2021 EPA Human Health Benchmarks for Pesticides Table

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2021 EPA Human Health Benchmarks for Pesticides Chronic HHBP cCancer a,fAcute or One Acute HHBP Chronic or b,fChronic or d,eCarcinogenic Acute or One Day Sensitive Quantification Common Name Day HHBPs Sensitive Lifestage/ Lifetime PAD Lifetime HBBP (E-6 to E-4) PAD (mg/kg/day) Lifestage/ (Q1) Values (CSF) (ppb) Population (mg/kg/day) HHBPs (ppb) ppb Population (mg/kg/day)-1 General 1,2,4- Triazole 0.03 200 Children 0.005 30 - - Population General 2, 4 - DB DMA 0.15 4200 Females 13-49 yrs 0.15 890 - - Population General 2,4-DP-p + salt & ester 1.25 8330 Children 0.06 400 - - Population 2,6-Dichlorobenzamide General 0.1 700 Children 0.045 270 - - (BAM) Population 3,5-Dibromo-4- General hydroxybenzonitrile 0.08 500 Children 0.015 89 - - Population butyrate General 4-Chlorophenoxyacetic acid -- -- -- 1.32 7810 - - Population General Abamectin 0.0025 17 Children 0.0025 15 - - Population Acephate 0.0003 2 Children 0.0003 2 Females 13-49 yrs - - General Acequinocyl 0.073 490 Children 0.027 160 - - Population General Acetamiprid 0.1 700 Children 0.071 420 - - Population General Acetochlor -- -- -- 0.02 100 - - Population Acibenzolar-S-methyl 0.082 550 Children 0.082 460 Females 13-49 yrs - - General ADBACg -- -- -- 0.44 2600 - - Population General Afidopyropen 0.16 4500 Females 13-49 yrs 0.08 500 - - Population General Allethrinsh 0.03 200 Children 0.008 50 - - Population Alpha-Cypermethrin 0.005 30 Children -- -- -- - - General Aluminum Phosphide 0.018 120 Children 0.0113 66.9 - - Population General Amicarbazone 0.1 700 Children 0.023 140 - - Population Aminocyclopyrachlor + General -- -- -- 2.79 16500 - - ester & salt Population General Aminopyralid + salts -- -- -- 0.5 3000 - - Population General Amisulbrom 2 10000 Children 0.54 3200 - - Population General Amitraz 0.0125 83.3 Children 0.0005 3 - - Population Anthraquinone -- -- -- -- -- -- 0.0617 0.48-48.0 General Aquashade -- -- -- 5 30000 - - Population General Asulam + sodium salt -- -- -- 0.36 2100 - - Population General Azinphos-methylg 0.003 20 Children 0.0015 8.9 - - Population General Azoxystrobin 0.67 4500 Children 0.18 1070 - - Population General Benalaxyl-M -- -- -- 0.02 100 0.0059 5.01-501 Population General Benfluralin -- -- -- 0.005 30 - - Population General Benomyl 0.025 170 Children 0.013 77 0.00239 12.4-1240 Population General Bensulfuron methyl -- -- -- 0.2 1000 - - Population General Bensulide 0.15 1000 Children 0.005 30 - - Population General Benthiavalicarb-isopropyl -- -- -- 0.099 590 0.062795 0.47115-47.115 Population General Benzene Sulfonic Acid -- -- -- 0.5 3000 - - Population General Benzobicyclon -- -- -- 0.636 3760 - - Population Benzobicyclon (Metabolite General 0.00027 1.8 Children 0.00004 0.2 - - B) Population General Benzovindiflupyr 0.1 700 Children 0.082 490 - - Population Beta Cyfluthrin 0.0117 78 Children -- -- -- - - General Bicyclopyrone 0.01 300 Females 13-49 yrs 0.00028 1.7 - - Population General Bifenazate 0.1 3000 Females 13-49 yrs 0.01 60 - - Population Bifenthrin 0.031 210 Children -- -- -- - - General Bispyribac-sodium -- -- -- 0.1 600 - - Population General Bitertanol 0.05 1000 Females 13-49 yrs 0.0021 12 - - Population General Bixafen 2.5 17000 Children 0.03 200 - - Population General Boscalid -- -- -- 0.22 1300 - - Population General Bromoxynil, phenol + esters 0.08 500 Children 0.015 89 0.103 0.287-28.7 Population General Bromuconazoleh 0.1 3000 Females 13-49 yrs 0.009 50 - - Population General Buprofezin 2 60000 Females 13-49 yrs 0.033 200 - - Population General Butafenacil -- -- -- 0.012 71 - - Population Butoxypolypropylene General -- -- -- 1.2 7100 - - Glycoli Population General Butralin 0.082 2300 Females 13-49 yrs 0.1 600 - - Population General Cacodylic acid + sodium salt 0.12 800 Children 0.014 83 - - Population General Cadusafos 0.00002 0.1 Children 0.000001 0.006 - - Population General Captan 0.1 3000 Females 13-49 yrs 0.13 770 - - Population General Carbendazim (MBC) 0.14 930 Children 0.14 830 0.00239 12.4-1240 Population General Carfentrazone-ethyl -- -- -- 0.03 200 - - Population General Chlorantraniliprole -- -- -- 1.58 9350 - - Population Chlorethoxyfos 0.00014 0.93 Children 0.00005 0.3 Females 13-49 yrs - - General Chlorfenapyr 0.05 300 Children 0.05 300 - - Population General Chlorflurenol Methyl Ester -- -- -- 0.1 600 - - Population General Chlorimuron-ethyl 1 7000 Children 0.09 500 - - Population General Chlormequat chloride 1 7000 Children 0.05 300 - - Population General Chloronebg -- -- -- 0.013 77 - - Population General Chlorpropham -- -- -- 0.005 30 - - Population Chlorpyrifos methyl 0.00033 2.2 Children 0.00033 1.9 Females 13-49 yrs - - General Chlorsulfuron -- -- -- 0.05 300 - - Population General Clethodim 1 7000 Children 0.3 2000 - - Population General Clodinafop-propargyl 0.05 1000 Females 13-49 yrs 0.0032 19 - - Population General Clofentezine -- -- -- 0.013 77 0.0376 0.787-78.7 Population General Clomazone 1 30000 Females 13-49 yrs 0.84 5000 - - Population General Clopyralid + salts -- -- -- 0.15 890 - - Population General Cloquintocet-mexyl 1 30000 Females 13-49 yrs 0.04 200 - - Population General Cloransulam-Methyl -- -- -- 0.1 600 - - Population General Clothianidin 0.25 1700 Children 0.098 580 - - Population General Coumaphos 0.0025 17 Children 0.0003 2 - - Population General Cyantraniliprole -- -- -- 0.01 60 - - Population General Cyazofamid -- -- -- 0.948 5610 - - Population General Cyclanilide 0.5 3000 Children 0.002 10 - - Population General Cycloate 0.066 440 Children 0.005 30 - - Population General Cyflufenamid -- -- -- 0.044 260 - - Population General Cyflumetofen -- -- -- 0.17 1000 - - Population Cyfluthrin 0.0117 78 Children -- -- -- - - General Cyhalofop-butyl -- -- -- 0.01 60 - - Population Cyhalothrin 0.00093 6.2 Children -- -- -- - - General Cyhexatin 0.0067 45 Children 0.0025 15 - - Population General Cymoxanil 0.08 2000 Females 13-49 yrs 0.03 200 - - Population Cypermethrin 0.0716 477 Children -- -- -- - - General Cyproconazole 0.02 600 Females 13-49 yrs 0.01 60 - - Population General Cyprodinil 2 10000 Children 0.027 160 - - Population General Cyprosulfamide -- -- -- 0.39 2300 - - Population General Cyromazine 0.83 5500 Children 0.5 3000 - - Population General DDAC 0.1 3000 Females 13-49 yrs 0.1 600 - - Population General DDBSA -- -- -- 0.5 3000 - - Population Daminozide -- -- -- -- -- -- 0.0087 3.4-340 Dantochlor (BCDMH) 1 30000 Females 13-49 yrs 1 6000 Females 13-49 yrs - - Deltamethrin 0.015 100 Children -- -- -- - - General Desmedipham 0.1 700 Children 0.04 200 - - Population General 0.01 300 Females 13-49 yrs 0.0018 11 - - Diaminochlorotriazine (DACT Population General Dichlobenil 0.45 13000 Females 13-49 yrs 0.01 60 - - Population General Dichloran 0.05 1000 Females 13-49 yrs 0.0025 15 - - Population General Dichlormid 0.01 70 Children 0.0022 13 - - Population Dichlorvos 0.00083 5.5 Children 0.00006 0.3 Females 13-49 yrs - - General Diclofop-methyl 0.1 3000 Females 13-49 yrs 0.0023 14 0.0736 0.402-40.2 Population General Diclosulam -- -- -- 0.05 300 - - Population General Dicofolg 0.05 300 Children 0.0004 2 - - Population Dicrotophos 0.00007 0.5 Children 0.00003 0.2 Females 13-49 yrs - - General Diethanolamine Mefluidide 0.58 3900 Children 0.015 89 - - Population General Diethofencarb -- -- -- 0.5 3000 - - Population General Difenoconazole 0.25 1700 Children 0.01 60 - - Population General Difenzoquat methyl sulfate -- -- -- 0.083 490 - - Population General Diflubenzuron -- -- -- 0.02 100 - - Population General Diflufenzopyr + sodium salt 1 30000 Females 13-49 yrs 0.26 1500 - - Population General Dimethenamid 2 10000 Children 0.05 300 - - Population General Dimethenamid-P 2 10000 Children 0.05 300 - - Population General Dimethipin -- -- -- 0.0218 129 - - Population General Dimethoate 0.013 87 Children 0.0022 13 - - Population General Dimethomorph 0.25 1700 Children 0.11 650 - - Population General Dinocap 0.004 100 Females 13-49 yrs 0.00038 2.2 - - Population General Dinotefuran 1.25 8330 Children 1 6000 - - Population Diphacinoneg 0.002 10 Children -- -- -- - - General Diphenylamine -- -- -- 0.1 600 - - Population General Diquat dibromide 0.75 5000 Children 0.005 30 - - Population General Disodium methanearsonate 0.1 700 Children 0.03 200 - - Population General Dithianon 0.02 600 Females 13-49 yrs 0.006 40 - - Population General Dithiopyr -- -- -- 0.0036 21 - - Population General Dodine -- -- -- 0.02 100 - - Population General d-Phenothrin (Sumithrin) 0.3 8000 Females 13-49 yrs 0.07 400 - - Population General Ecolyst 0.5 3000 Children 0.14 830 - - Population General Emamectin Benzoate 0.0025 17 Children 0.0025 15 - - Population General Endosulfan 0.015 100 Children 0.006 40 - - Population General Epoxiconazole 0.05 1000 Females 13-49 yrs 0.02 100 0.0304 0.973-97.3 Population EPTC (Ethyl General 0.2 1000 Children 0.05 300 - - dipropylthiocarbamate) Population Esfenvalerate 0.011 73 Children -- -- -- - - General Ethaboxam -- -- -- 0.055 330 - - Population General Ethalfluralin 0.75 21000 Females 13-49 yrs 0.04 200 0.089 0.33-33 Population General Ethametsulfuron -- -- -- 4.5 27000 - - Population General Ethephon 0.06 400 Children 0.06 400 - - Population General Ethiprole 0.35 2300 Children 0.03 200 - - Population Ethofumesate 0.3 8000 Females 13-49 yrs 0.3 2000 Females 13-49 yrs - - Ethoprop 0.00042 2.8 Children 0.000065 0.37 Females 13-49 yrs 0.0281 1.05-105 General Ethoxyquin 1 7000 Children 0.04 200 - - Population General Ethyl Parathiong 0.0003 2 Children 0.00003 0.2 - - Population General Ethylene Chlorohydring 0.1 700 Children 0.045 270 - - Population General Etofenprox
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  • Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using the LUMI-CELL ER Bioassay

    Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using the LUMI-CELL ER Bioassay

    DEVELOPMENTAL AND REPRODUCTIVE TOXICITY Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using The LUMI-CELL ER Bioassay John D. Gordon1, Andrew C: Chu1, Michael D. Chu2, Michael S. Denison3, George C. Clark1 1Xenobiotic Detection Systems, Inc., 1601 E. Geer St., Suite S, Durham, NC 27704, USA 2Alta Analytical Perspectives, 2714 Exchange Drive, Wilmington, NC 28405, USA 3Dept. of Environmental Toxicology, Meyer Hall, Univ. of California, Davis; Davis, CA 95616 USA Introduction Organochlorine pesticides are found in many ecosystems worldwide as result of agricultural and industrial activities and exist as complex mixtures. The use of these organochlorine pesticides has resulted in the contamination of lakes and streams, and eventually the animal and human food chain. Many of these pesticides, such as pp ’-DDT, pp ’-DDE, Kepone, Vinclozolin, and Methoxychlor (a substitute for the banned DDT), have been described as putative estrogenic endocrine disruptors, and act by mimicking endogenous estrogen 1-3 . Estrogenic compounds can have a significant detrimental effect on the endocrine and reproductive systems of both human and other animal populations 4 . Previous studies have shown a strong association between several EDCs (17p-Estradiol, DES, Zeralanol, Zeralenone, Coumestrol, Genistein, Biochanin A, Diadzein, Naringenin, Tamoxifin) and estrogenic activity via uterotropic assay, cell height, gland number, increased lactoferrin, and a transcriptional activity assay using BG1Luc4E2 cells4 . Some other examples of the effects of these EDCs are: decreased reproductive success and feminization of males in several wildlife species; increased hypospadias along with reductions in sperm counts in men; increase in the incidence of human breast and prostate cancers; and endometriosis 3-5 .
  • Butafenacil – a New Complimentary Premix Partner for Triasulfuron Or Glyphosate for the Enhanced Knockdown and Residual Contro

    Butafenacil – a New Complimentary Premix Partner for Triasulfuron Or Glyphosate for the Enhanced Knockdown and Residual Contro

    Thirteenth Australian Weeds Conference Butafenacil – a new complimentary premix partner for triasulfuron or glyphosate for the enhanced knockdown and residual control of weeds in broadacre cropping situations Brett A. Davies Syngenta Crop Protection Pty. Ltd., 140–150 Bungaree Road, PO Box 249, Pendle Hill, New South Wales 2145, Australia Summary Butafenacil is a new pyrimidindione her- symptoms, however, are already observed within a few bicide released in Australia during the 2002 season hours after treatment. as a complementary component of two new products Trial work with butafenacil has been ongoing in – Logran® B-Power™ (a premix of triasulfuron and Australia since the mid 1990s. Over 100 trials have butafenacil), for the pre-emergent control of grass been conducted to investigate the complimentary activ- and broadleaf weeds in wheat, and Touchdown® B- ity of butafenacil in mixtures with either glyphosate or Power™ (a premix of glyphosate and butafenacil), for triasulfuron for pre-plant weed knockdown and in-crop the knockdown control of grass and broadleaf weeds residual weed. prior to the sowing of cereals crops. This paper provides a summary of the spectrum Effi cacy trials conducted throughout the major of activity on weeds of both Touchdown B-Power (a grain growing regions of Australia since the late premix of 5 g a.i. kg-1 of butafenacil, and 225 g a.i. 1990s have highlighted the enhanced knockdown kg-1 of glyphosate present as the isopropylamine salt control of Touchdown B-Power at rates ranging from as a suspension concentrate formulation) and Logran 184–636 g a.i. ha-1 of a wide range of both grass and B-Power (a premix of 200 g a.i.