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DED UN 18 O 98 F yyyy N yyyy Y O T R E I T H C E N O yyyy A E S S S L T A E A C R C I yyyyN S M S E E H C C T N IO A December 2001 Vol. LXXX, No. 4 yyyyC N • AMERI Monthly Meeting Medicinal Chemistry Group Symposium on Lyosomal Storage Diseases Book Review Emergency Preparedness Planning by T.S. Pasquarelli and F.K. Wood-Black Board of Directors Notes of the meeting of September 13 Amino Acid Tales Teaching the amino acids for an introductory biochemistry course à la Chaucer 2 The Nucleus December 2001 The Northeastern Section of the American 2002 Norris Award nominations sought ____________________4 Chemical Society, Inc. Office: Marilou Cashman, 23 Cottage St., Natick, MA 01760. 1-800-872-2054 Monthly Meeting ______________________________________ 5 (Voice or FAX) or 508-653-6329. Joint meeting with the Medicinal Chemistry Group. Mini-Symposium on e-mail: [email protected] Any Section business may be conducted Approaches to the treatment of Lyosomal Storage Diseases via the business office above. NESACS Homepage: http://www.NESACS.org Book Review __________________________________________7 Frank R. Gorga, Webmaster Emergency Preparedness Planning. A Primer for Chemists, by Timothy L. Washington, D.C. ACS Hotline: 1-800-227-5558 Pasquarelli and Frankie K. Wood-Black; reviewed by Robert Litman Officers 2001 Chair: Board of Directors 8 Timothy B. Frigo _____________________________________ Advanced Magnetics, Inc. Notes of the meeting of September 13, 2001 61 Mooney St., Cambridge, MA 02138 617-497-2070x3007; [email protected] Chair-Elect: Green Chemistry Challenge ______________________________9 Morton Z. Hoffman The Presidential Green Chemistry Challenge Awards Program for 2002 Chemistry Department, Boston University Boston, MA 02215-2507; 617-353-2494 [email protected] Amino Acid Tales______________________________________10 Immediate Past Chair: Doris Lewis From the J. Chem. Ed. of 1978 – by LeRoy Kuehl: Teaching amino acids in an Chemistry Dept., Suffolk University introductory biochemistry course in the style of the Canterbury Tales 41 Temple St., Boston, MA 02114 617-573-8546; [email protected] Secretary: Comment____________________________________________14 Michael Singer Don’t Follow the Crowd; recollections by Arno Heyn Sigma RBI 1 Strathmore Rd. Natick, MA 01760-2447 Puzzle Column ____________________________________17, 20 781-994-0523; fax:781-994-0677 [email protected] A new crossword puzzle and the solution to the November puzzles Treasurer: James Piper Cover: ACS President-Elect Eli M. Pearce cutting the ACS’ 125th birthday cake Simmons College, 300 The Fenway Boston, MA 02115, 617-521-2722 (photo by M.Z. Hoffman) Auditor: Anthony Rosner Deadlines: February 2002 issue: December 14, 2001 Archivist: Myron Simon March 2002 issue: January 17, 2002 20 Somerset Rd. Newton, MA 02465; 617-332-5273 [email protected] Trustees: Esther A.H. Hopkins, Michael E. Strem, Joseph A. Lima Councilors: Alternate Councilors: Term ends 12/31/2001 Term ends 12/31/2001 Thomas R. Gilbert Michael P. Filosa The Nucleus is distributed to the members of the Northeastern Section of the American Chemical Michael J. Hearn Morton Z. Hoffman Society, to the secretaries of the Local Sections, and to editors of all local A.C.S. Section publications. Arlene Wick Light Donald O. Rickter Forms close for advertising on the 1st of the month of the preceding issue. Text must be received by the Michael Singer Sophia R. Su editor six weeks before the date of issue. Term Ends 12/31/2002 Term ends 12/31/2002 Editor: Arno Heyn, 21 Alexander Rd., Newton, MA 02461, Mary T. Burgess Michael J. Dube Tel: 617-969-5712, FAX: 617-527-2032; e-mail:[email protected] Michaeline F. Chen Jean Fuller-Stanley Doris I. Lewis Patrick M. Gordon Associate Editor: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273 Julia H. Miwa John L. Neumeyer Board of Publications: Marietta H. Schwartz (Chair), Patrick M. Gordon, Frank R. Gorga, E. Joseph Term Ends 12/31/2003 Term ends 12/31/2003 Billo (Consultant) Catherine E. Costello Arno H.A. Heyn Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, William Klemperer Wallace J. Gleekman Tel: 978-456-8622 Truman Light(to12/31/01)Alfred Viola Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050, Dororthy J. Phillips Derk A. Wierda Tel: 781-837-0424; FAX: 781-837-8792 Contributing Editors: Mukund Chorghade, Patricia Hamm, Features; Edward Atkinson, History of All Chairs of standing Chemistry; Maryann Solstad, Health; Dennis Sardella, Book Reviews; Marietta H. Committees, the editor Schwartz, Software Reviews; E. Joseph Billo, Puzzles. of THE NUCLEUS, and the Trustees of Section Calendar Coordinator: Donald O. Rickter, e-mail: [email protected] Funds are members of the Proofreaders: E. Joseph Billo, Donald O. Rickter, M.S. Simon Board of Directors. Any Webpage: Webmaster: Frank R. Gorga, [email protected] Councilor of the American Chemical Society Asst. Webmasters:Terry Brush, [email protected] residing within the section area is an ex officio Kurt Heinselman, [email protected] member of the Board of Directors. Copyright 2001, Northeastern Section of the American Chemical Society, Inc. The Nucleus December 2001 3 Directions Nominations Corporate Patrons Alfa Aesar, a Johnson Matthey Com- Since the MIT Lot is likely to James Flack Norris Award For pany be full and on-street parking is Outstanding Achievement In Hoechst Marion Roussel Co. The Teaching Of Chemistry Pharm-Eco Laboratories, Inc. tight, use the T, if possible. Physical Sciences, Inc. Red Line: Exit at Kendall, walk Nominations are being received for the Polaroid Corporation towards Boston on Main St., turn right 2002 James Flack Norris Award for Strem Chemicals, Inc. into Wadsworth St. The large building Outstanding Achievement in the Teach- Corporate Sponsors ing of Chemistry. The Norris Award, on the left at the corner of Wadsworth Aerodyne Research, Inc. one of the oldest awards given by a and Memorial Drive is the Sloan Ctr. AstraZeneca R&D section of the American Chemical Borregaard Synthesis, Inc. (less than 500 feet from the T). Society, is presented annually by the Bristol-Myers Squibb Driving: Northeastern Section. The Award con- Cambridge Isotope Labs sists of a certificate and an honorarium Consulting Resources Corporation From Down-town Boston:* Cross to of $3,000. Nominees must have served Dike, Bronstein, Roberts & Cambridge on the Longfellow Bridge with special distinction as teachers of Cushman, LLP and at the end of the bridge take the chemistry at any level: secondary Houghton Chemical Corp. right turns into Memorial Drive (west- school, college, and/or graduate school. JEOL, USA, Inc. bound). Take the first right, into Since 1951, awardees have included MassTrace, Inc. Wadsworth St. and at the end of eminent and less-widely-known but New England Biolabs Wadsworth Street, turn right into Main equally effective teachers at all levels. Organix, Inc. Street. The entrance to the MIT Sloan The awardee for 2001 was Dr. Dennis Pfizer, Inc. parking lot is 1/2 block on the right. G. Peters of the Department of Chem- Research Biochemicals Int’l Parking free after 3:30 pm. istry at Indiana University, Blooming- Zymark Corporation ton, IN. From Back Bay, Brookline, etc.: Take Nominations for 2002 will be as are necessary to convey the nomi- Storrow Drive to the Cambridge St. received until April 16, 2002. The nee’s qualification for the award. These Exit, stay left and cross the Charles nominating material must be limited to may show the impact of the nominee’s River on Longfellow Bridge, follow * 30 pages and focus specifically on the teaching in inspiring colleagues and above. nominee’s contribution to and effec- students toward an active life in chem- tiveness in teaching chemistry, as dis- From Cambridge: Take Main St. east- istry and/or related sciences, or may tinguished from research. These attest to the influence of the nominee’s bound. The MIT Sloan parking lot is qualities are demonstrated by a con- other activities in chemical education, on the right shortly after the Kendall densed curriculum vitae as a portion of such as textbooks, journal articles, or Square T-stop, just beyond Wadsworth a nominating letter which, in turn, is other professional activity at the N St. Parking free after 3:30 pm. supported by as many seconding letters national level. Materials should be of 8 1/2 by 11 inch size but should not include books or reprints or software. Please direct questions about the con- tent of a nomination to Dr. Patricia Samuel, [email protected]. Nomi- nations should be sent before April 16, 2002, to Ms. Marilou Cashman, NESACS, 23 Cottage St., Natick, MA 01760. N The Northeastern Section Office will be closed from Friday, November 30 through Sunday, December 9. P Dinner reservations for the December Meeting should be called in to the Sec- tion office at 800-872-2054 or e- mailed to [email protected] through November 29. Any changes after Nov. 29, please call Mrs. Karen Piper at 978-456-8622. 4 The Nucleus December 2001 ciency through the transduction of a small number of the patients’ cells with a normal copy of the gene. These Monthly Meeting genetically modified cells then serve as th The 829 Meeting of the Northeastern Section of the American a depot for expression and secretion of Chemical Society, held jointly with the Medicinal Chemistry the affected enzyme into the circula- Group tion. The degree of correction required Mini-Symposium on Approaches to the Treatment of Lyosomal will vary with each disease, but may be Storage Diseases only 1 to 10% of normal levels, based on individuals with milder, late-onset Thursday, December 6, 2001 disease. Several different gene delivery MIT Faculty Club, 50 Memorial Drive, Cambridge, MA platforms including the use of retrovi- 3:00 pm Refreshments ral, adenoviral, adeno-associated viral 3:30 pm Seng H.
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