A GUIDE TO ROBUST STATISTICAL METHODS IN NEUROSCIENCE Authors: Rand R. Wilcox1∗, Guillaume A. Rousselet2 1. Dept. of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA 2. Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, 58 Hillhead Street, G12 8QB, Glasgow, UK ∗ Corresponding author:
[email protected] ABSTRACT There is a vast array of new and improved methods for comparing groups and studying associations that offer the potential for substantially increasing power, providing improved control over the probability of a Type I error, and yielding a deeper and more nuanced understanding of data. These new techniques effectively deal with four insights into when and why conventional methods can be unsatisfactory. But for the non-statistician, the vast array of new and improved techniques for comparing groups and studying associations can seem daunting, simply because there are so many new methods that are now available. The paper briefly reviews when and why conventional methods can have relatively low power and yield misleading results. The main goal is to suggest some general guidelines regarding when, how and why certain modern techniques might be used. Keywords: Non-normality, heteroscedasticity, skewed distributions, outliers, curvature. 1 1 Introduction The typical introductory statistics course covers classic methods for comparing groups (e.g., Student's t-test, the ANOVA F test and the Wilcoxon{Mann{Whitney test) and studying associations (e.g., Pearson's correlation and least squares regression). The two-sample Stu- dent's t-test and the ANOVA F test assume that sampling is from normal distributions and that the population variances are identical, which is generally known as the homoscedastic- ity assumption.