bioRxiv preprint doi: https://doi.org/10.1101/2020.02.20.957688; this version posted February 20, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 USP29 is a novel non-canonical Hypoxia Inducible Factor-α 2 activator 3 4 Amelie S Schober1,2, Inés Martín-Barros1, Teresa Martín-Mateos1, Encarnación Pérez- 5 Andrés1, Onintza Carlevaris1, Sara Pozo1, Ana R Cortazar1, Ana M Aransay1,3, Arkaitz 6 Carracedo1,4,5,6, Ugo Mayor5,6, Violaine Sée2, Edurne Berra1,4* 7 8 (1) Centro de Investigación Cooperativa en Biociencias CIC bioGUNE, Basque Research and Technology 9 Alliance (BRTA), Parque Tecnológico de Bizkaia-Ed.801A, 48160 Derio, Spain. 10 (2) Institute of Integrative Biology, Department of Biochemistry, Centre for Cell Imaging, University of 11 Liverpool, L69 7ZB Liverpool, United Kingdom. 12 (3) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 13 Madrid, Spain. 14 (4) Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain. 15 (5) Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Leioa, 16 Bizkaia, Spain. 17 (6) Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Bizkaia, Spain. 18 (*) correspondence:
[email protected] (+34 946 572 506) 19 20 21 22 23 24 25 26 27 28 Running title: USP29 deubiquitinates HIF-α 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.02.20.957688; this version posted February 20, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder.