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Home , Bevantolol, Calcium channel blocker, Carboxyamidotriazole, Channel modulator, Darodipine, Efonidipine

Calcium Channel Ca2+ channels; Ca channels

Calcium channel is an which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your rate, which can further reduce pressure, relieve () and control an irregular heartbeat.

www.MedChemExpress.com 1 Calcium Channel Inhibitors, Antagonists, Activators, & Modulators

(+)- (2R/S)-6-PNG Cat. No.: HY-B1671 (6-Prenylnaringenin) Cat. No.: HY-115681

(+)-Kavain, a main kavalactone extracted from Piper (2R/S)-6-PNG (6-Prenylnaringenin) is a Cav3.2 2+ methysticum, has anticonvulsive properties, (T-type) Ca (IC50=991 nM). attenuating vascular contraction (2R/S)-6-PNG suppresses neuropathic allodynia in through interactions with voltage-dependent Na+ mouse pain models. and Ca2+ channels.

Purity: 99.98% Purity: ≥99.0% Clinical Data: Launched Clinical Data: Phase 1 Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 5 mg

(R)-(+)-Bay-K-8644 (R)- D3 hydrochloride Cat. No.: HY-15125 Cat. No.: HY-B0612DS

(R)-(+)-Bay-K-8644 is a calcium channel (R)-lercanidipine D3 (hydrochloride) is a inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ deuterium labeled (R)-Lercanidipine hydrochloride.

currents (IBa) (IC50=975 nM). (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is a .

Purity: 99.69% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

(R)-Lercanidipine hydrochloride (Rac)-MEM 1003 Cat. No.: HY-B0612D Cat. No.: HY-121604

(R)-Lercanidipine hydrochloride is the (Rac)-MEM 1003 is the racemate of MEM 1003. MEM R-enantiomer of Lercanidipine. (R)-lercanidipine 1003, a dihydropyridine compound, is a potent hydrochloride is a calcium channel blocker. L-type Ca2+ channel antagonist and has the potential for Alzheimer’s disease research.

Purity: >98% Purity: 99.52% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

(S)-(-)-Bay-K-8644 (S)-Lercanidipine hydrochloride Cat. No.: HY-15124 Cat. No.: HY-B0612E

(S)-(-)-Bay-K-8644 is an of L-type Ca2+ (S)-Lercanidipine hydrochloride is the channel. (S)-(-)-Bay-K-8644 activates Ba2+ S-enantiomer of Lercanidipine hydrochloride.

currents (IBa) (EC50=32 nM). (S)-lercanidipine hydrochloride is a potent calcium channel blocker.

Purity: 98.52% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 1 mg

(S)- D7 hydrochloride (S)-Verapamil hydrochloride ((S)-(-)-Verapamil D7 hydrochloride) Cat. No.: HY-135336AS ((S)-(-)-Verapamil hydrochloride) Cat. No.: HY-135336A

(S)-Verapamil D7 hydrochloride ((S)-(-)-Verapamil (S)-Verapamil hydrochloride (S(-)-Verapamil D7 hydrochloride) is a deuterium labeled hydrochloride) inhibits leukotriene C4 (LTC4) and (S)-Verapamil hydrochloride. (S)-Verapamil calcein transport by MRP1. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) hydrochloride leads to the death of potentially inhibits leukotriene C4 (LTC4) and calcein resistant tumor cells. transport by MRP1. Purity: >98% Purity: 99.39% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

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(±)-Praeruptorin A 1,2,4-Trihydroxybenzene Cat. No.: HY-N0081 Cat. No.: HY-W010451

(±)-Praeruptorin A is the di-esterified product of 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a cis-khellactone (CKL) and the major active by-product of coffee bean roasting, increases ingredient in Peucedani Radix which consists of intracellular Ca2+ concentration in rat thymic the dried roots of Peucedanum lymphocytes. praeruptorumDunn (Apiaceae).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 10 mM × 1 mL, 500 mg

1-Octanol 2-Aminoethyl diphenylborinate (Octanol) Cat. No.: HY-W032013 (2-APB) Cat. No.: HY-W009724

1-Octanol (Octanol), a saturated fatty , is 2-Aminoethyl diphenylborinate (2-APB) is a a T-type calcium channels (T-channels) inhibitor cell-permeable inhibitor of IP3R. 2-Aminoethyl with an IC50 of 4 μM for native T-currents. diphenylborinate also inhibits the store-operated 1-Octanol is a highly attractive biofuel with Ca2+ (SOC) channel and activates some TRP diesel-like properties. channels (V1, V2 and V3).

Purity: ≥98.0% Purity: 98.03% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg Size: 10 mM × 1 mL, 5 mg

4-​Bromo A23187 8-Bromo-cGMP sodium Cat. No.: HY-N6694 Cat. No.: HY-101379A

4-Bromo A23187 is a halogenated analog of the 8-Bromo-cGMP sodium, a membrane-permeable analogue highly selective calcium ionophore A-23187. of cGMP, is a PKG (protein kinase G) activator. 4-Bromo A23187a calcium modulator, induces 8-Bromo-cGMP sodium significantly inhibits Ca2+ apoptosis in different cells, including HL-60 macroscopic currents and impairs insulin release cells. stimulated with high K+.

Purity: ≥99.0% Purity: ≥99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

ABT-639 ABT-639 hydrochloride Cat. No.: HY-19721 Cat. No.: HY-101616

ABT-639 is a novel, peripherally acting, selective ABT-639 hydrochloride is a novel, peripherally T-type Ca2+ channel blocker. acting, selective T-type Ca2+ channel blocker.

Purity: 99.36% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Acetylcholine chloride ACT-709478 (ACh chloride) Cat. No.: HY-B0282 Cat. No.: HY-112723

Acetylcholine chloride (ACh chloride), a ACT-709478 is a potent, selective, orally active, , is a potent agonist. and brain penetrating T-type calcium channel Acetylcholine chloride is a modulator of the blocker. ACT-709478 is used in the research of activity of (DAergic) through generalized . the stimulation of nicotinic acetylcholine receptors (nAChRs). Purity: ≥98.0% Purity: 99.68% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 5 mg, 10 mg, 50 mg, 100 mg

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AE0047 Hydrochloride Cat. No.: HY-U00284 Cat. No.: HY-B0317

AE0047 Hydrochloride is a calcium blocker, used Amlodipine, an agent and an orally in the research of hypertensive disease. active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium.

Purity: >98% Purity: 99.57% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Amlodipine besylate Amlodipine maleate (Amlodipine benzenesulfonate) Cat. No.: HY-B0317B Cat. No.: HY-B0317A

Amlodipine besylate (Amlodipine benzenesulfonate), Amlodipine maleate is a dihydropyridine calcium an antianginal agent and an orally active channel blocker, acts as an orally active dihydropyridine calcium channel blocker, works by antianginal agent. Amlodipine maleate blocks the blocking the voltage-dependent L-type calcium voltage-dependent L-type calcium channels, thereby channels, thereby inhibiting the initial influx of inhibiting the initial influx of calcium. calcium. Purity: 99.92% Purity: 99.85% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Anipamil Annonacin Cat. No.: HY-U00044 Cat. No.: HY-N2877

Anipamil is a long-acting calcium channel Annonacin is an Acetogenin and promotes blocker, used for the treatment of cardiovascular cytotoxicity via a pathway inhibiting the disease. mitochondrial complex. Annonacin is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg

Aranidipine (MPC1304) Cat. No.: HY-U00212 (CS 905) Cat. No.: HY-B0023

Aranidipine (MPC1304) is a Ca2+ channel Azelnidipine(CS 905; Calblock) is a novel antagonist with potent and long-lasting dihydropyridine derivative, a L-type calcium antihypertensive effects. channel blocker, and an antihypertensive.

Purity: 99.33% Purity: 99.84% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Azelnidipine D7 Azumolene (CS-905 D7) Cat. No.: HY-B0023S (EU4093 free base) Cat. No.: HY-113920A

Azelnidipine D7 is deuterium labeled Azelnidipine, Azumolene (EU4093 free base), a analog, which is a L-type calcium channel blocker. is a . Azumolene is a ryanodine (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research. Purity: >98% Purity: 98.54% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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Barnidipine hydrochloride (Mepirodipine; YM-09730-5(Free base)) Cat. No.: HY-107322A (Mepirodipine hydrochloride; YM-09730-5) Cat. No.: HY-107322

Barnidipine (Mepirodipine) is an L-type calcium Barnidipine hydrochloride (Mepirodipine antagonist (CaA) with high affinity for [3H] hydrochloride) is an L-type calcium antagonist 3 initrendipine binding sites (Ki=0.21 nmol/l), has (CaA) with high affinity for [ H] initrendipine selective action against CaA receptors. binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors.

Purity: >98% Purity: 98.77% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Bay K 8644 hydrochloride Cat. No.: HY-10588 (KW-3049) Cat. No.: HY-B1448

Bay K 8644, a dihydropyridine compound, is a Benidipine hydrochloride is a dihydropyridine specific L-type Ca2+ channel agonist. Bay K 8644 calcium channel blocker for the treatment of high increases Ca2+ influx through sarcolemmal Ca2+ (). channels by increasing the open time of the channel.

Purity: 98.16% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 100 mg

Bepridil hydrochloride hydrochloride hydrate ((±)-Bepridil hydrochloride (CERM 1978) Cat. No.: HY-103315 hydrate; Org 5730 hydrochloride hydrate) Cat. No.: HY-16952A

Bepridil hydrochloride (CERM 1978) is a calcium Bepridil hydrochloride hydrate ((±)-Bepridil channel blocker, with antianginal activity. hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects.

Purity: 99.76% Purity: 99.73% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg

Bevantolol hydrochloride Cat. No.: HY-121186 (Butyl 4-aminobenzoate) Cat. No.: HY-B1430

Bevantolol hydrochloride is a selective β1 and Butamben (Butyl 4-aminobenzoate) has local

α1- with pKi values effect. Butamben results in long-lasting of 7.83, 6.9 in rat cerebral cortex, respectively. relief from pain, without impairing motor function Bevantolol hydrochloride is a potent Ca2+ or other sensory functions. antagonist.

Purity: ≥98.0% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 500 mg, 5 g

BX430 Ca2+ channel agonist 1 Cat. No.: HY-110237 Cat. No.: HY-41076

BX430 is a potent and selective noncompetitive Ca2+ channel agonist 1 is an agonist of N-type allosteric human P2X4 receptor channels Ca2+ channel and an inhibitor of Cdk2, with antagonist with an IC50 of 0.54 μM. BX430 has EC50s of 14.23 μM and 3.34 μM, respectively, and species specificity. BX430 is used for chronic is used as a potential treatment for motor nerve pain and cardiovascular disease. terminal dysfunction.

Purity: 99.87% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg

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Calcium channel-modulator-1 Calcium ionophore I Cat. No.: HY-U00135 (ETH 1001) Cat. No.: HY-136460

Calcium channel-modulator-1 is a calcium channel Calcium ionophore I (ETH 1001) is a selective 2+ modulator; blocks aortic contraction with an IC50 Ca ionophore for biological membranes. of 0.8 μM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg, 25 mg

CALP1 CALP1 TFA Cat. No.: HY-P1077 Cat. No.: HY-P1077A

CALP1 is a (CaM) agonist (Kd of CALP1 TFA is a calmodulin (CaM) agonist

88 µM) with binding to the CaM (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium

influx and apoptosis (IC50 of 44.78 µM) through influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. inhibition of calcium channel opening.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

CALP2 CALP2 TFA Cat. No.: HY-P1076 Cat. No.: HY-P1076A

CALP2 is a calmodulin (CaM) antagonist ( CALP2 TFA is a calmodulin (CaM) antagonist

(Kd of 7.9 µM)) with high affinity for binding (Kd of 7.9 µM) with high affinity for binding to to the CaM EF-hand/Ca2+-binding site. CALP2 the CaM EF-hand/Ca2+-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ activity and increases intracellular Ca2+ concentrations. concentrations. Purity: >98% Purity: 98.48% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg

CALP3 Cat. No.: HY-P1075 (L-651582; CAI) Cat. No.: HY-16126

CALP3, a Ca2+-like , is a potent Ca2+ Carboxyamidotriazole (L-651582) is a cytostatic channel blocker that activates EF hand motifs of inhibitor of nonvoltage-operated calcium channels Ca2+-binding proteins. CALP3 can functionally mimic and calcium channel-mediated signaling 2+ increased [Ca ]i by modulating the activity of pathways. Carboxyamidotriazole shows Calmodulin (CaM), Ca2+ channels and pumps. anti-tumor, anti-inflammatory and antiangiogenic effects. Purity: 99.27% Purity: ≥99.0% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 1 mg, 5 mg, 10 mg Size: 10 mM × 1 mL, 1 mg

Carboxyamidotriazole Orotate Catharanthine (L-651582 Orotate; CAI Orotate) Cat. No.: HY-16125 ((+)-3,4-Didehydrocoronaridine) Cat. No.: HY-N0252

Carboxyamidotriazole Orotate (L-651582 Orotate) is Catharanthine is an isolated from the orotate salt form of Carboxyamidotriazole Madagascar periwinkle, inhibits (CAI), an orally bioavailable signal transduction voltage-operated L-type Ca2+ channel, with inhibitor. anti-cancer and blood pressure-lowering activity.

Purity: 99.89% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 100 mg

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Catharanthine Sulfate Catharanthine Tartrate ((+)-3,4-Didehydrocoronaridine Sulfate) Cat. No.: HY-N0252B ((+)-3,4-Didehydrocoronaridine Tartrate) Cat. No.: HY-N0252A

Catharanthine Sulfate Catharanthine Tartrate is an alkaloid isolated ((+)-3,4-Didehydrocoronaridine Sulfate) is an from Madagascar periwinkle, inhibits alkaloid isolated from Madagascar voltage-operated L-type Ca2+ channel, with periwinkle, inhibits voltage-operated L-type anti-cancer and blood pressure-lowering activity. Ca2+ channel, with anti-cancer and blood pressure-lowering activities. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg, 50 mg

Cav 2.2 blocker 1 CDN1163 Cat. No.: HY-119373 Cat. No.: HY-101455

Cav 2.2 blocker 1 (compound 9) is a N-type CDN1163 is an allosteric sarco/endoplasmic calcium channel (Cav 2.2) blocker for the reticulum Ca2+-ATPase (SERCA) activator that 2+ treatment of pain, with an IC50 of 1 nM. improves Ca homeostasis. CDN1163 attenuates diabetes and metabolic disorders.

Purity: 99.30% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Cilnidipine Cinepazide Maleate (FRC-8653) Cat. No.: HY-17404 (MD-67350) Cat. No.: HY-66010

Cilnidipine(FRC8653) is a dual L- and N-type Cinepazide Maleate (MD-67350) is a calcium channel blocker and displays derivative and acts as a weak calcium channel antihypertensive, sympatholytic and blocker. Cinepazide Maleate is a potent vasodilator neuroprotective activity. and can be used for the research of cerebrovascular diseases, including ischemic stroke, brain infarct et. al.
. Purity: 99.98% Purity: 99.64% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

Cinnarizine D8 Cat. No.: HY-B1090 Cat. No.: HY-B1090S

Cinnarizine is an and a calcium Cinnarizine D8 is a deuterium labeled Cinnarizine. channel blocker, promote cerebral blood flow, used Cinnarizine is an antihistamine and a calcium to treat cerebral apoplexy, post-trauma cerebral channel blocker. symptoms, and cerebral arteriosclerosis.

Purity: 99.67% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 1 mg

Clevidipine CP-060 Cat. No.: HY-17436 Cat. No.: HY-U00354

Clevidipine is a short-acting dihydropyridine CP-​060 is a potent Ca2+ antagonist, inhibits calcium channel antagonist (IC50= 7.1 nM, V(H) = Ca2+ overload and possesses antioxidant and -40 mV ) under development for treatment of cardioprotective activities. perioperative hypertension.

Purity: 99.69% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

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Cromolyn sodium CV-159 (Disodium Cromoglycate; FPL-670) Cat. No.: HY-B0320A Cat. No.: HY-19025

Cromolyn sodium (Disodium Cromoglycate; FPL-670) CV-159 is a unique dihydropyridine Ca2+ is an antiallergic . Cromolyn sodium is a antagonist with an anti-calmodulin (CaM) action,

GSK-3β inhibitor with an IC50 of 2.0 µM. and has antiinflammatory activities.

Purity: 99.10% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 1 mg, 5 mg

Cyclic ADP-​ribose Cyclic ADP-​ribose ammonium (cADPR) Cat. No.: HY-N7395 (cADPR ammonium) Cat. No.: HY-N7395A

Cyclic ADP-ribose (cADPR) is a potent second Cyclic ADP-ribose ammonium (cADPR ammonium) is a messenger for calcium mobilization that is potent second messenger for calcium synthesized from NAD+ by an ADP-ribosyl cyclase. mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase.

Purity: >98% Purity: ≥90.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500 μg Size: 500 μg

Cyclopiazonic acid Dantrolene sodium Cat. No.: HY-N6771 (F 440) Cat. No.: HY-14657

Cyclopiazonic acid (CPA), a neurotoxic secondary Dantrolene sodium is a inhibitor of calcium metabolite (SM) made by A. flavus, is a nanomolar channel proteins, inhibiting the release of Ca2+ inhibitor of endoplasmic reticulum calcium ATPase from the sarcoplasm. Dantrolene sodium is a (Ca2+ATPase; SERCA) and a potent inducer of cell relaxant which acts by blocking death in . beyond the neuromuscular junction. Purity: ≥99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg Size: 1 mg, 5 mg

Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Cat. No.: HY-12542A (PY 108-068; PY-108068) Cat. No.: HY-U00086

Dantrolene sodium hemiheptahydrate is a skeletal Darodipine (PY 108-068, PY-108068) is a potent muscle relaxant which acts by blocking muscle calcium channel antagonist. contraction beyond the neuromuscular junction. Dantrolene sodium hemiheptahydrate is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Purity: ≥98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg Size: 1 mg, 5 mg

Dehydronitrosonisoldipine DHBP dibromide Cat. No.: HY-Z0816 (Diheptylviologen dibromide) Cat. No.: HY-101237

Dehydronitrosonisoldipine is a calcium channel DHBP dibromide is an inhibitor for calcium antagonist. release and a muscle relaxant.

Purity: ≥98.0% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg, 25 mg Size: 10 mM × 1 mL, 100 mg

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Diltiazem hydrochloride Cat. No.: HY-B0632 (CRD-401) Cat. No.: HY-14656

Diltiazem is an orally active L-type Ca2+ channel Diltiazem hydrochloride is a Ca2+ influx blocker, with antihypertensive and antiarrhythmic inhibitor (slow channel blocker or calcium effects. Diltiazem can be used for the research of antagonist). cardiac , hypertension, and angina pectoris.

Purity: >98% Purity: 99.83% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Dopropidil Cat. No.: HY-U00151 (SR 33589) Cat. No.: HY-A0016

Dopropidil is a novel anti-anginal calcium ion Dronedarone (SR 33589), a derivative of modulating agent, possessing intracellular calcium (HY-14187), is a class III antiarrhythmic antagonist activity and anti-ischemic effects in agent for the study of (AF) several predictive animal models. and .

Purity: >98% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

DS16570511 Ebselen Cat. No.: HY-115595 (SPI-1005; PZ-51; CCG-39161) Cat. No.: HY-13750

DS16570511 is cell-permeable inhibitor of the Ebselen (SPI-1005), a glutathione peroxidase mitochondrial calcium uniporter, which blocks mimetic, is a potent voltage-dependent calcium the MCU- or MICU1-dependent increase of Ca2+ channel (VDCC) blocker. Ebselen potently inhibits pro influx. M (IC50=0.67 μM) and COVID-19 virus

(EC50=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Purity: 98.37% Purity: 99.58% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Efonidipine hydrochloride (NZ-105; (±)-Efonidipine) Cat. No.: HY-12502 (NZ-105 hydrochloride) Cat. No.: HY-12502B

Efonidipine(NZ-105) is a dual T-type and L-type Efonidipine Hcl (NZ-105) is a dual T-type and calcium channel blocker (CCB). L-type calcium channel blocker (CCB).

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Efonidipine hydrochloride monoethanolate Ethacrynic acid (NZ-105 hydrochloride monoethanolate) Cat. No.: HY-12502A Cat. No.: HY-B1640

Efonidipine hydrochloride monoethanolate (NZ-105 Ethacrynic acid is a . Ethacrynic acid is hydrochloride monoethanolate) is a dual T-type and an inhibitor of glutathione S-transferases (GSTs). L-type calcium channel blocker (CCB). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation.

Purity: 99.83% Purity: 99.98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

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Ethacrynic acid D5 Cat. No.: HY-108538 Cat. No.: HY-B1378

Ethacrynic acid D5 is a deuterium labeled Ethosuximide, a widely prescribed anti-epileptic Ethacrynic acid. Ethacrynic acid is a diuretic. drug, improves the phenotypes of multiple Ethacrynic acid is an inhibitor of glutathione neurodegenerative disease models and blocks the S-transferases (GSTs). Ethacrynic acid is a low voltage activated T-type calcium channel. potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Purity: >98% Purity: 99.54% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg

Etiracetam Etripamil (UCB 6474) Cat. No.: HY-B0106A (MSP-2017; (-)-MSP-2017) Cat. No.: HY-17611

Etiracetam (UCB 6474) is an acetylcholine agonist Etripamil (MSP-2017) is a short-acting L-type and a drug of the family. Less calcium-channel antagonist, can be used for the active than its S-enantiomer (UCB research of Paroxysmal Supraventricular L059). (PSVT).

Purity: 99.91% Purity: 98.68% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

Fantofarone (SR 33557) Cat. No.: HY-105117 (HA-1077; AT877) Cat. No.: HY-10341A

Fantofarone is a highly potent Calcium Channel Fasudil (HA-1077; AT877), is a nonspecific antagonist. RhoA/ROCK inhibitor and also has inhibitory

effect on protein kinases, with an Ki of 0.33 μM

for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Purity: 99.91% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Fasudil Hydrochloride (HA-1077 Hydrochloride; AT-877 Hydrochloride) Cat. No.: HY-10341 Cat. No.: HY-B0309

Fasudil Hydrochloride (HA-1077 Hydrochloride; Felodipine, a dihydropyridine, is a potent, AT877 Hydrochloride), is a nonspecific RhoA/ROCK vasoselective calcium channel antagonist. inhibitor and also has inhibitory effect on Felodipine lowers blood pressure (BP) by selective

protein kinases, with an Ki of 0.33 μM for ROCK1, action on , especially in

IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM the resistance vessels. for ROCK2 and PKA, PKC, PKG, respectively. Purity: 99.91% Purity: 98.93% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 200 mg, 500 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Fendiline hydrochloride Cat. No.: HY-B0984 Cat. No.: HY-B1221

Fendiline hydrochloride is a nonselective calcium Flufenamic acid is a non-steroidal channel blocker. anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating… Purity: 99.98% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 100 mg

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Flunarizine dihydrochloride Cat. No.: HY-B0358A (R 6218; Redeptin) Cat. No.: HY-B1655

Flunarizine dihydrochloride is a potent dual Fluspirilene is a non-competitive antagonist of + 2+ Na /Ca channel (T-type) blocker. Flunarizine L-type calcium channels with an IC50 of 0.03 μM. dihydrochloride is a D2 dopamine receptor Fluspirileneis a long-acting injectable depot antagonist. drug used for schizophrenia.

Purity: 99.92% Purity: ≥99.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg Size: 10 mM × 1 mL, 5 mg

Gabapentin enacarbil Cat. No.: HY-A0057 (XP-13512) Cat. No.: HY-16216

Gabapentin (Neurontin) is a pharmaceutical drug, (XP-13512) is a prodrug for specifically a GABA analog. It was originally the and drug gabapentin. developed to treat , and currently is also used to relieve .

Purity: ≥98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

Gabapentin hydrochloride Cat. No.: HY-A0057A (Methoxyverapamil) Cat. No.: HY-14276

Gabapentin (Neurontin) is a pharmaceutical drug, Gallopamil (Methoxyverapamil), a methoxy specifically a GABA analog. It was originally derivative of Verapamil, is a phenylalkylamine developed to treat epilepsy, and currently is also calcium antagonist. Gallopamil inhibits acid used to relieve neuropathic pain. secretion in a concentration-dependent manner with

an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Purity: ≥98.0% Purity: ≥98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

Gallopamil hydrochloride Ginsenoside Rd (Methoxyverapamil hydrochloride) Cat. No.: HY-14276A (Gypenoside VIII) Cat. No.: HY-N0043

Gallopamil hydrochloride (Methoxyverapamil Ginsenoside Rd inhibits TNFα-induced NF-κB hydrochloride), a methoxy derivative of Verapamil, transcriptional activity with an IC50 of is a phenylalkylamine calcium antagonist. 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd Gallopamil hydrochloride inhibits acid secretion inhibits expression of COX-2 and iNOS mRNA. 2+ in a concentration-dependent manner with an IC50 Ginsenoside Rd also inhibits Ca influx. of 10.9 μM. Purity: ≥98.0% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

Ginsenoside Rf Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; (Panaxoside Rf) Cat. No.: HY-N0601 Chikusetsusaponin V) Cat. No.: HY-N0607

Ginsenoside Rf is a trace component of ginseng Ginsenoside Ro (Polysciasaponin P3; root. Ginsenoside Rf inhibits N-type Ca2+ Chikusetsusaponin 5; Chikusetsusaponin V) exhibits channel. a Ca2+-antagonistic antiplatelet effect with an

IC50 of 155 μM. Ginsenoside Ro reduces the

production of TXA2 more than it reduces the activities of COX-1 and TXAS. Purity: 99.48% Purity: 99.21% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

www.MedChemExpress.com 11

Glaucine Gomisin J (O,O-Dimethylisoboldine; S-(+)-; NSC 34396) Cat. No.: HY-N3945 Cat. No.: HY-N0385

Glaucine (O,O-Dimethylisoboldine) is an alkaloid Gomisin J is a small molecular weight lignan found isolated from flavum Crantz with in Schisandra chinensis and has been demonstrated to antitussive, bronchodilation and anti-inflammatory have vasodilatory activity. properties.

Purity: >98% Purity: ≥99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg

GSK-7975A GSK1016790A Cat. No.: HY-12507 Cat. No.: HY-19608

GSK-7975A is a potent and orally available CRAC GSK1016790A is a potent and selective transient channel inhibitor. receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells.

Purity: 99.79% Purity: 99.67% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

GV-58 Heteroclitin D Cat. No.: HY-12498 Cat. No.: HY-N2077

GV-58 is a potent, selective N- and P/Q-type Ca2+ Heteroclitin D is a lignin from Kadsura medicinal channels agonist with EC50 of 7.21/8.81 uM for plants with anti-liqid peroxidation. Heteroclitin N-type/P-Q-type Ca2+ channel; 20-fold less potent D inhibits L-type calcium channels. CDK inhibitor activity.

Purity: 99.09% Purity: 99.91% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg Size: 1 mg, 5 mg

Huwentoxin XVI Huwentoxin XVI TFA Cat. No.: HY-P1078 Cat. No.: HY-P1078A

Huwentoxin XVI, an analgesic, is a highly Huwentoxin XVI TFA, an analgesic, is a highly reversible and selective mammalian N-type calcium reversible and selective mammalian N-type calcium

channel (IC50 of ~60 nM) antagonist from Chinese channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium TFA has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels. channels, potassium channels or sodium channels. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Hyperforin dicyclohexylammonium salt fumarate ( DCHA) Cat. No.: HY-116330A (U70226E) Cat. No.: HY-B0387

Hyperforin dicyclohexylammonium salt (Hyperforin Ibutilide fumarate is a Class III antiarrhythmic DCHA) is a transient receptor canonical 6 (TRPC6) agent that is indicated for acute cardioconversion channels activator. Hyperforin of atrial fibrillation and atrial flutter of a dicyclohexylammonium salt modulates Ca2+ levels recent onset to sinus rhythm. by activating Ca2+-conducting non-selective canonical TRPC6 channels. Purity: 98.17% Purity: 99.83% Clinical Data: No Development Reported Clinical Data: Launched Size: 500 μg, 1 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Iganidipine ILS-920 Cat. No.: HY-101685 Cat. No.: HY-106345

Iganidipine is a Ca2+ antagonist. ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Ionomycin Ionomycin calcium (SQ23377) Cat. No.: HY-13434 (SQ23377 calcium) Cat. No.: HY-13434A

Ionomycin (SQ23377) is a potent, selective Ionomycin calcium (SQ23377 calcium) is a potent, calcium ionophore and an produced by selective calcium ionophore and an antibiotic Streptomyces conglobatus. Ionomycin (SQ23377) is produced by Streptomyces conglobatus. Ionomycin highly specific for divalent cations calcium (SQ23377 calcium) is highly specific for (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes divalent cations (Ca>Mg>Sr=Ba). Ionomycin apoptosis. (SQ23377) promotes apoptosis. Purity: ≥99.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg (14.1 mM * 500 μL in Ethanol) Size: 5 mg

Isotachysterol 3 Cat. No.: HY-130704 (PN 200-110) Cat. No.: HY-B0233

Isotachysterol 3 is an analog of 1,25-dihydrox Isradipine(Dynacirc) is a calcium channel blocker D3. Isotachysterol 3 stimulates intestinal with an IC50 of 34±8 μM. Target: Calcium Channel calcium transport and calcium Isradipine(Dynacirc) is a calcium channel blocker mobilization in anephric rats. with an IC50 of 34±8 μM.

Purity: 98.02% Purity: 98.98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Istaroxime hydrochloride JNJ-26489112 (PST2744 hydrochloride) Cat. No.: HY-15718A Cat. No.: HY-12596

Istaroxime hydrochloride is a Na+/K+-ATPase JNJ-26489112, a CNS-active agent, exhibits inhibitor (IC50=0.11 μM) and a broad-spectrum anticonvulsant activity in rodents sarcoplasmic/endoplasmic reticulum calcium ATPase against audiogenic, electrically-induced, and 2 (SERCA 2) activator. chemically-induced seizures.

Purity: 99.32% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

JTV-519 free base JTV-519 hemifumarate (K201 free base) Cat. No.: HY-15293A (K201 hemifumarate) Cat. No.: HY-15293B

JTV-519 free base (K201 free base) is a JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial Ca2+-stimulated ATPase (SERCA) and a of ryanodine receptors in striated muscle. agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. Antiarrhythmic and cardioprotective properties.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 13

L-Ascorbic acid L-Ascorbic acid sodium salt (L-Ascorbate; Vitamin C) Cat. No.: HY-B0166 (Sodium L-ascorbate; Vitamin C sodium salt) Cat. No.: HY-B0166A

L-Ascorbic acid (L-Ascorbate), an electron donor, L-Ascorbic acid sodium salt (Sodium L-ascorbate), is an endogenous antioxidant agent. L-Ascorbic an electron donor, is an endogenous antioxidant

acid inhibits selectively Cav3.2 channels with an agent. L-Ascorbic acid sodium salt inhibits

IC50 of 6.5 μM. L-Ascorbic acid is also a collagen selectively Cav3.2 channels with an IC50 of 6.5 deposition enhancer and an elastogenesis μM. inhibitor. Purity: 99.92% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g Size: 10 mM × 1 mL, 500 mg, 1 g

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) Cat. No.: HY-N0215 Cat. No.: HY-B0347

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic Lacidipine (Lacipil, Motens) is a L-type calcium acid) is an essential isolated from channel blocker. Target: Calcium Channel Escherichia coli. L-Phenylalanine is a α2δ subunit Lacidipine, a novel third-generation of voltage-dependent Ca+ channels antagonist with dihydropyridine calcium channel blocker, has been

a Ki of 980 nM. demonstrated effective for hypertension.

Purity: 99.30% Purity: 99.98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 200 mg, 1 g Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg

Lemildipine Lercanidipine (NB-818; NPK-1886) Cat. No.: HY-19663 Cat. No.: HY-B0612

Lemildipine is a new dihydropyridine calcium Lercanidipine is a lipophilic third-generation entry blocker. dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect.

Purity: 98.06% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Lercanidipine hydrochloride Cat. No.: HY-B0612A ((S)-Amlodipine; Levoamlodipine) Cat. No.: HY-14744

Lercanidipine hydrochloride is a lipophilic Levamlodipine ((S)-Amlodipine) is a powerful third-generation dihydropyridine-calcium channel dihydropyridine calcium channel blocker, blocker (DHP-CCB). Lercanidipine hydrochloride has possessing properties and used in the long lasting antihypertensive action and treatment of hypertension and angina. reno-protective effect.

Purity: 99.94% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg Size: 1 mg, 5 mg

Levamlodipine besylate ((S)-Amlodipine besylate; Levoamlodipine besylate) Cat. No.: HY-14744A Cat. No.: HY-112075

Levamlodipine besylate ((S)-Amlodipine besylate) Lidoflazine is a high affinity blocker of the is a powerful dihydropyridine calcium channel HERG (human ether-a-go-go-related gene) K+ blocker, possessing vasodilation properties and channel. Lidoflazine is an antianginal calcium used in the treatment of hypertension and angina. channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. Purity: 99.91% Purity: ≥98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 10 mM × 1 mL, 10 mg

14 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Lomerizine dihydrochloride (KB-2796) Cat. No.: HY-B0768A Cat. No.: HY-B0419

Lomerizine dihydrochloride is an antagonist of L- Manidipine is a calcium channel blocker that is and T-type voltagegated calcium channels. used clinically as an antihypertensive.

Purity: 99.97% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg Size: 1 mg, 5 mg

Manidipine dihydrochloride McN5691 (CV-4093) Cat. No.: HY-17403 (RWJ26240) Cat. No.: HY-U00218

Manidipine dihydrochloride (CV-4093) is a McN5691 is a voltage-sensitive calcium channel dihydropyridine compound and a calcium channel blocker. blocker for Ca2+ current with IC50 of 2.6 nM.

Purity: 98.87% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg Size: 1 mg, 5 mg

Methyl homoveratrate Cat. No.: HY-W042039 (Ro 40-5967) Cat. No.: HY-15553

Methyl homoveratrate, a metabolite of RWJ-26240 in Mibefradil (Ro 40-5967) is a calcium channel vivo, can be identified in plasma, urine and blocker with moderate selectivity for T-type Ca2+ faecal extract. McN5691 (RWJ-26240) is a channels displaying IC50s of 2.7 μM and 18.6 μM voltage-sensitive calcium channel blocker. for T-type and L-type currents, respectively.

Purity: 97.34% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg

Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) Cat. No.: HY-15553A (DS5565) Cat. No.: HY-12650

Mibefradil dihydrochloride (Ro 40-5967 Mirogabalin (DS-5565) is a novel, preferentially dihydrochloride) is a calcium channel blocker selective α2δ-1 ligand characterized by high with moderate selectivity for T-type Ca2+ potency and selectivity to the α2δ-1 subunit of channels displaying IC50s of 2.7 μM and 18.6 μM voltage-sensitive calcium channel complexes in for T-type and L-type currents, respectively. the CNS.

Purity: 98.78% Purity: 99.31% Clinical Data: Phase 1 Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Mirogabalin besylate MK-8998 (DS 5565 besylate) Cat. No.: HY-108006 Cat. No.: HY-101096

Mirogabalin besylate is a selective and orally MK-8998 (compound 33) is a potent and selective available ligand for the α2δ subunit of inhibitor of the T-type calcium channel. voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. Purity: 99.98% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 15

ML218 ML218 hydrochloride Cat. No.: HY-103309 Cat. No.: HY-103309A

ML218 is a potent, selective and orally active ML218 hydrochloride is a potent, selective and T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) orally active T-type Ca2+ channels (Cav3.1,

inhibitor with IC50s of 310 nM and 270 nM for Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM Cav3.2 and Cav3.3, respectively. ML218 inhibits and 270 nM for Cav3.2 and Cav3.3, respectively. the burst activity in subthalamic nucleus (STN) ML218 hydrochloride inhibits the burst activity in neurons. subthalamic nucleus (STN) neurons. Purity: 99.49% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg Size: 1 mg, 5 mg

MRS 1523 MRS1845 Cat. No.: HY-121119 Cat. No.: HY-103310

MRS 1523 is a potent and selective A3 MRS1845 is a selective store-operated calcium

receptor antagonist with Ki values of 18.9 nM and (SOC) channel inhibitor with an IC50 of 1.7 μM.

113 nM for human and rat A3 receptors, MRS1845 is an ORAI1 inhibitor. respectively. In rat this corresponds to

selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. Purity: >98% Purity: 99.27% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mg, 25 mg, 50 mg, 100 mg

Myomodulin N-type calcium channel blocker-1 Cat. No.: HY-P0268 Cat. No.: HY-100310

Myomodulin is a neuropeptide present in molluscs, N-type calcium channel blocker-1 is an orally insects, and gastropods. active analgesic agent which shows high affinity to functionally block N-type calcium channels with

an IC50 of 0.7 μM in the IMR32 assay.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg

NecroX-5 Ned 19 Cat. No.: HY-104015 Cat. No.: HY-103316A

NecroX-5 is a derivative of the NecroX, reduces Ned 19 is a selective membrane-permeant non intracellular calcium concentration, and competitive NAADP antagonist and inhibits 2+ possesses anti-inflammatory and anti-cancer NAADP-mediated Ca signaling, with an IC50 of activity. 65 nM. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice. Purity: 99.31% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg Size: 1 mg, 5 mg

Ned-K Nexopamil racemate Cat. No.: HY-131041 Cat. No.: HY-101727

Ned-K is a nicotinic acid adenine dinucleotide Nexopamil racemate is the racemate of Nexopamil. 2+ phosphate (NAADP) antagonist. Ned-K is effective Nexopamil is a combined Ca /5-HT2 antagonist at dampening simulated ischaemia and reperfusion on thrombus formation in vivo and on (sIR)-induced Ca2+ oscillations in aggregation in vitro. cardiomyocytes.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

16 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Nicardipine D3 hydrochloride (YC-93 free base) Cat. No.: HY-12515 (YC-93 D3) Cat. No.: HY-12515AS

Nicardipine (YC-93 free base) is a calcium Nicardipine D3 hydrochloride (YC-93 D3) is the channel blocker with an IC50 of 1 μM for blocking deuterium labeled Nicardipine hydrochloride. cardiac calcium channels. Nicardipine acts as an Nicardipine hydrochloride is a calcium channel agent for chronic stable angina and for blocker with an IC50 of 1 μM for blocking cardiac controlling blood pressure. calcium channels.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Nicardipine hydrochloride (YC-93) Cat. No.: HY-12515A (BAY-a-1040) Cat. No.: HY-B0284

Nicardipine hydrochloride (YC-93) is a calcium Nifedipine (BAY-a-1040) is a potent calcium channel blocker with an IC50 of 1 μM for blocking channel blocker and drug of choice for cardiac cardiac calcium channels. Nicardipine insufficiencies. hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure.

Purity: 99.72% Purity: 99.35% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g, 10 g

Nifedipine D6 (BAY-a-1040 D6) Cat. No.: HY-B0284S (FK235; FR34235) Cat. No.: HY-14284

Nifedipine D6 (BAY-a-1040 D6) is deuterium labeled Nilvadipine is a potent calcium channel nifedipine, and nifedipine is a potent calcium antagonist, and the IC50 value is around 0.1 nM. channel blocker.

Purity: >98% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 500 mg

Nimodipine (BAY-e 9736) Cat. No.: HY-B0265 (BAY-k 5552) Cat. No.: HY-17402

Nimodipine(Nimotop) is a dihydropyridine Nisoldipine(BAY-k 5552; Sular) is a calcium derivative and an analogue of the calcium channel channel blocker belonging to the dihydropyridines blocker Nifedipine, with antihypertensive class, specific for L-type Cav1.2 with IC50 of 10 activity.Nimodipine decreases intracellular free nM. IC50 value: 10 nM Target: L-type Cav1.2 Ca2+,Beclin-1 and autophagy. Nisoldipine is a potent blocker of L-type calcium channels. Purity: 99.76% Purity: 99.20% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 100 mg, 500 mg, 1 g

Nitrendipine NNC 55-0396 (BAY-E-5009) Cat. No.: HY-B0424 (NNC 55-0396 dihydrochloride) Cat. No.: HY-50722

Nitrendipine (BAY-E-5009), an analogue of NNC 55-0396, Mibefradil derivative, is a highly Nifedipine (HY-B0284), is a dihydropyridine selective T-type calcium channel blocker; displays calcium channel blocker with vasodilator action. IC50 values of 6.8 and > 100 μM for inhibition Nitrendipine has antihypertensive effect. of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

Purity: 99.25% Purity: 99.24% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg, 1 g Size: 10 mM × 1 mL, 1 mg, 5 mg

www.MedChemExpress.com 17

Norverapamil D7 ((±)-Norverapamil; D591) Cat. No.: HY-135328 ((±)-Norverapamil D7; D591 D7) Cat. No.: HY-135328S

Norverapamil ((±)-Norverapamil), an N-demethylated Norverapamil D7 is a deuterium labeled metabolite of Verapamil, is a L-type calcium Norverapamil ((±)-Norverapamil). Norverapamil, an channel blocker and a P-glycoprotein (P-gp) N-demethylated metabolite of Verapamil, is a function inhibitor. L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Norverapamil hydrochloride Nothofagin ((±)-Norverapamil hydrochloride; D591 hydrochloride) Cat. No.: HY-100750 Cat. No.: HY-113919

Norverapamil hydrochloride ((±)-Norverapamil Nothofagin, a dihydrochalcone, is isolated from hydrochloride), an N-demethylated metabolite of rooibos (Aspalathus linearis). Nothofagin Verapamil, is a L-type calcium channel blocker and downregulates NF-κB translocation through blocking a P-glycoprotein (P-gp) function inhibitor. calcium influx.

Purity: 98.26% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 2 mg, 5 mg, 10 mg, 25 mg Size: 5 mg

NP118809 NS-638 (39-1B4) Cat. No.: HY-14462 Cat. No.: HY-101428

NP118809 is a potent N-type calcium channel NS-638 is a small nonpeptide molecule with 2+ + blocker, with an IC50 of 0.11 μM; also less Ca -channel blocking properties. K -stimulated potently inhibits L-type calcium channel with an intracellular Ca2+-elevation is blocked with an

IC50 of 12.2 μM. IC50 value of 3.4 μM.

Purity: 98.62% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg Size: 10 mM × 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Ophiopogonin D Palonidipine Cat. No.: HY-N0515 Cat. No.: HY-108997

Ophiopogonin D, isolated from the tubers of Palonidipine is a calcium antagonist which is Ophiopogon japonicus, is a rare naturally occurring potential for the therapy of angina-pectoris and

C29 steroidal glycoside. hypertension.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg

Paxilline PD0176078 Cat. No.: HY-N6778 Cat. No.: HY-U00236

Paxilline is an indole alkaloid mycotoxin from PD0176078 is a newly found N-type Calcium Penicillium paxilli, acts as a potent BK channel blocker. channels inhibitor by an almost exclusively closed-channel block mechanism.

Purity: 99.70% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 1 mg, 5 mg

18 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

PD173212 Penfluridol Cat. No.: HY-103318 (R-16341) Cat. No.: HY-B1077

PD173212 is a selective N-type voltage sensitive Penfluridol is a highly potent, first generation calcium channel (VSCC) blocker, with an IC50 of diphenylbutylpiperidine antipsychotic. 36 nM in IMR-32 assays.

Purity: 95.01% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 2 mg, 5 mg, 10 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

Pinaverium bromide Praeruptorin C Cat. No.: HY-111613 Cat. No.: HY-N0079

Pinaverium bromide is an L-type calcium channel Praeruptorin C is a main bioactive constituent of blocker with selectivity for the gastrointestinal Peucedanum praeruptorum (also known as tract, effectively relieves pain, diarrhea and Bai-Hua Qian Hu). Praeruptorin C is a calcium ′ intestinal discomfort, provides good therapeutic antagonist with pD2 value of 5.7. efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients. Purity: ≥98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg Size: 5 mg, 10 mg, 20 mg

Praeruptorin E Cat. No.: HY-N6066 (OPC-13340) Cat. No.: HY-19664

Praeruptorin E is a main bioactive constituent of Pranidipine (OPC-13340) is a potent, long acting Peucedanum praeruptorum (also known as 1,4-dihydropyridine calcium channel blocker with Bai-Hua Qian Hu). Praeruptorin C is a calcium antihypertensive activity. ′ antagonist with pD2 value of 5.2.

Purity: >98% Purity: 99.85% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Propiverine hydrochloride ProTx-I Cat. No.: HY-116408A Cat. No.: HY-P1073

Propiverine hydrochloride is a bladder spasmolytic ProTx-I, a venom toxin of the tarantula with calcium antagonistic and Thrixopelma pruriens, is a potent, selective properties. Propiverine hydrochloride can be used CaV3.1 channel blocker with IC50 values of 0.2 μM for the research of overactive blaqdder and and 31.8 μM for hCaV3.1 and hCaV3.2 urinary incontinence. respectively.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 25 mg Size: 1 mg, 5 mg

Psoralenoside Cat. No.: HY-N7503 (CVT 303; RS 43285-003) Cat. No.: HY-B0280

Psoralenoside is a benzofuran glycoside from Ranolazine (CVT 303) is an anti-angina drug that Psoralea corylifolia. Psoralenoside exhibits high achieves its effects by inhibiting the late phase binding affinities against H1, of inward sodium current (INa and IKr with IC50 calmodulin, and voltage-gated L-type calcium values of 6 μM and 12 μM, respectively) without channels (E-value≥-6.5 Kcal/mol). affecting or blood pressure (BP).

Purity: >98% Purity: 98.38% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg

www.MedChemExpress.com 19

Ranolazine dihydrochloride Ru360 (CVT 303 dihydrochloride; RS 43285) Cat. No.: HY-17401 Cat. No.: HY-122898

Ranolazine dihydrochloride (CVT 303 Ru360, an oxygen-bridged dinuclear ruthenium amine dihydrochloride) is an anti-angina drug that complex, is a selective mitochondrial calcium achieves its effects by inhibiting the late phase uptake inhibitor. Ru360 potently inhibits Ca2+

of inward sodium current (INa and IKr with IC50 uptake into mitochondria with an IC50 of 0.184 values of 6 μM and 12 μM, respectively) without nM. Ru360 binds to mitochondria with high

affecting heart rate or blood pressure… affinity (Kd of 0.34 nM). Purity: 99.67% Purity: ≥99.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg, 1 g, 5 g Size: 100 μg, 500 μg

Ruthenium red Semotiadil recemate fumarate (Ammoniated ruthenium oxychloride) Cat. No.: HY-103311 Cat. No.: HY-U00026

Ruthenium red (Ammoniated ruthenium oxychloride) Semotiadil recemate fumarate is the recemate of is a polycationic dye widely used for electron Semotiadil fumarate. Semotiadil fumarate is a microscopy (EM) of cells, tissues and vegetative novel vasoselective Ca2+ channel antagonist. bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Purity: ≥95.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 100 mg Size: 1 mg, 5 mg

SERCA2a activator 1 sFTX-3.3 Cat. No.: HY-124873 Cat. No.: HY-131942

2+ SERCA2a activator 1 (Compound A) is a sFTX-3.3 is a Ca channel antagonist with IC50s sarco/endoplasmic reticulum Ca2+-dependent of approximately 0.24 mM and 0.70 mM against ATPase 2a (SERCA2a) activator. SERCA2a activator P-type and N-type channels. 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for . Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Sipatrigine SM-6586 (619C89; BW 619C89) Cat. No.: HY-108335 Cat. No.: HY-19062

Sipatrigine (619C89), a neuroprotective agent, is SM-6586 is a calcium channel antagonist and a glutamate release inhibitor, voltage-dependent inhibitor of Na+/H+ and Na+/Ca2+ exchange and calcium channel inhibitor, transport, potentially for the treatment of penetrating the central . Has the cerebrovasular diseases and hypertension. potential in the study for focal cerebral and stroke. Purity: ≥99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg Size: 1 mg, 5 mg

SNX-482 SQ-31765 Cat. No.: HY-P1074 (SQ31765; SQ 31765) Cat. No.: HY-101740

SNX-482, a peptidyl toxin of the spider SQ-31765 is a benzazepine calcium channel Hysterocrates gigas, is a potent, high affinity, blocker.

selective and voltage-dependent R-type CaV2.3

channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

20 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

SR33805 Syntide 2 Cat. No.: HY-136909 Cat. No.: HY-P0271

SR33805 is a potent Ca2+ channel antagonist, with Syntide 2, a Ca2+- and calmodulin

EC50s of 4.1 nM and 33 nM in depolarized and (CaM)-dependent protein kinase II (CaMKII) polarized conditions, respectively. SR33805 blocks substrate peptide, selectively inhibits the L-type but not T-type Ca2+ channels. SR33805 can gibberellin (GA) response, leaving constitutive be used for the research of acute or chronic and abscisic acid-regulated events unaffected. failing . Purity: 99.04% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg, 10 mg

Syntide 2 TFA TDN345 Cat. No.: HY-P0271A Cat. No.: HY-101669

Syntide 2 (TFA), a Ca2+- and calmodulin TDN345 is a Ca2+ antagonist, used for the (CaM)-dependent protein kinase II (CaMKII) treatment of vascular and senile substrate peptide, selectively inhibits the including Alzheimer's disease. gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.

Purity: 99.76% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg

Teludipine hydrochloride hydrochloride (GR53992B; GX1296B) Cat. No.: HY-101621 Cat. No.: HY-16489A

Teludipine is a lipophilic calcium channel Terodiline hydrochloride is an M1-selective blocker. muscarinic receptor (mAChR) antagonist with

Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Purity: >98% Purity: 99.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg

Tetrandrine Thapsigargin (NSC-77037; d-) Cat. No.: HY-13764 Cat. No.: HY-13433

Tetrandrine (NSC-77037; d-Tetrandrine) is a Thapsigargin, an endoplasmic reticulum (ER) bis-benzyl-isoquinoline alkaloid, which inhibits stress inducer, is an inhibitor of microsomal voltage-gated Ca2+ current (ICa) and Ca2+-ATPase. Thapsigargin efficiently inhibits Ca2+-activated K+ current. coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types.

Purity: 99.90% Purity: 99.28% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg, 250 mg Size: 1 mg, 5 mg

Tiapamil hydrochloride (Ro 11-1781) Cat. No.: HY-101674 (McN 4853; RWJ 17021) Cat. No.: HY-B0122

Tiapamil hydrochloride is a calcium channel Topiramate (McN 4853) is a broad-spectrum blocker. antiepileptic agent. Topiramate is a GluR5 receptor antagonist.

Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

www.MedChemExpress.com 21

Topiramate D12 TPC2-A1-N (McN 4853 D12 ; RWJ 17021 D12) Cat. No.: HY-110234 Cat. No.: HY-131614

Topiramate D12 (McN 4853 D12) is a deuterium TPC2-A1-N is a powerful and Ca2+-permeable labeled Topiramate. Topiramate is a broad-spectrum agonist of two antiepileptic agent. Topiramate is a GluR5 pore channel 2 (TPC2), which plays receptor antagonist. its role by mimicking the physiological actions of NAADP.

Purity: >98% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

trans-Ned 19 Cat. No.: HY-103316 (3,5,5,-Trimethyloxazolidine-2,4-dione) Cat. No.: HY-A0092

trans-Ned 19, a NAADP antagonist and TPC Trimethadione blocker, suppresses the calcium signal in human (3,5,5,-Trimethyloxazolidine-2,4-dione) is an umbilical endothelial cells (HUVEC) and the anticonvulsant agent widely used rat aorta relaxation in response to low histamine against absences seizures. Trimethadione also is a concentrations. T-type calcium channel blocker which has antihyperalgesic effects. Purity: 99.53% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 50 mg

TTA-A2 TTA-Q6 Cat. No.: HY-111828 Cat. No.: HY-10388

TTA-A2 is a potent, selective and orally active TTA-Q6 is a selective T-type Ca2+ channel t-type voltage gated calcium channel antagonist, which can be used in the research of antagonist with reduced pregnane X receptor (PXR) neurological disease. activation.

Purity: ≥99.0% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg

UK-59811 hydrochloride UK51656 Cat. No.: HY-136189 Cat. No.: HY-101707

UK-59811 hydrochloride, a Br-dihydropyridine UK51656 is a calcium antagonist with IC50 of 4 derivative, is a potent bacterial homotetrameric nM. 2+ model voltage-gated Ca (CaV) channel CaVAb

inhibitor with an IC50 of 194 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Urolithin C Verapamil Cat. No.: HY-135897 ((±)-Verapamil; CP-16533-1) Cat. No.: HY-14275

Urolithin C, a gut-microbial metabolite of Ellagic Verapamil ((±)-Verapamil) is a calcium channel acid, is a -dependent activator of insulin blocker and a potent and orally active secretion. Urolithin C is a L-type Ca2+ channel first-generation P-glycoprotein (P-gp) inhibitor. opener and enhances Ca2+ influx. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart and angina research. Purity: 99.66% Purity: 98.82% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 50 mg

22 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Verapamil EP Impurity C hydrochloride Verapamil hydrochloride (NSC-609249 hydrochloride) Cat. No.: HY-136589 ((±)-Verapamil hydrochloride; CP-16533-1 hydrochloride) Cat. No.: HY-A0064

NSC-609249 hydrochloride is an impurity of Verapamil hydrochloride ((±)-Verapamil Verapamil (HY-14275). Verapamil is hydrochloride) is a calcium channel blocker and a calcium channel blocker and a potent a potent and orally active first-generation and orally active P-glycoprotein (P-gp) inhibitor. Verapamil first-generation P-glycoprotein hydrochloride also inhibits CYP3A4. (P-gp) inhibitor. Purity: >98% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Yangambin YS-201 Cat. No.: HY-N4267 Cat. No.: HY-U00137

Yangambin, a furofuran lignan, is already isolated YS-201 is a dihydropyridine-type calcium channel from plants such as member of the Annonaceae antagonist. YS-201 has the potential for angina family, including species of the genus Rollinia: pectoris and hypertension treatment. R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii.

Purity: >98% Purity: ≥99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Ziconotide TFA Cat. No.: HY-P0062 Cat. No.: HY-P0062A

Ziconotide is an analgesic agent and has been used Ziconotide TFA is an analgesic agent and has been to treat neuropathic and non-neuropathic pain. used to treat neuropathic and non-neuropathic pain.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Zonisamide sodium (AD 810; CI 912) Cat. No.: HY-B0124 (AD 810 sodium; CI 912 sodium) Cat. No.: HY-B0124A

Zonisamide (AD 810) is an inhibitor of zinc Zonisamide sodium (AD 810 sodium) is an inhibitor (CA), with Kis of 35.2 nM and of zinc enzyme carbonic anhydrase (CA), with Kis 20.6 nM for human mitochondrial isozyme hCA II and of 35.2 nM and 20.6 nM for human mitochondrial hCA V, respectively. Zonisamide has antiepileptic isozyme hCA II and hCA V, respectively. Zonisamide activity. Zonisamide can be used for the rsearch sodium has antiepileptic activity. for epilepsy, seizures and Parkinson's disease. Purity: 99.85% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 200 mg, 500 mg Size: 1 mg, 5 mg

ZSET1446 β-Amino Acid Imagabalin Hydrochloride (ST-101) Cat. No.: HY-11013 (PD-0332334) Cat. No.: HY-U00250

ZSET1446 is a novel cognitive enhancer that β-Amino Acid Imagabalin Hydrochloride (PD-0332334) significantly improves learning deficits in is a ligand for the α2δ subunit of the various types of Alzheimer disease (AD) models. voltage-dependent calcium channel.

Purity: 98.13% Purity: >98% Clinical Data: Phase 2 Clinical Data: Phase 3 Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 23

β-Cyfluthrin ω-Agatoxin IVA (beta-Cyfluthrin) Cat. No.: HY-B1837A Cat. No.: HY-P1080

β-Cyfluthrin (beta-Cyfluthrin) is a type II ω-Agatoxin IVA is a potent, selective P/Q type 2+ synthetic pyrethroid and also an active ingredient Ca channel blocker with IC50s of 2 nM and 90 nM of many insecticide products used for pestsin for P-type and Q-type Ca2+ channels,

agriculture. respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. Purity: 99.94% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 50 mg, 100 mg Size: 1 mg, 5 mg

ω-Agatoxin TK ω- GVIA Cat. No.: HY-P1079 Cat. No.: HY-P0189

ω-Agatoxin TK, a peptidyl toxin of the venom of ω-Conotoxin GVIA is an inhibitor of the N-type Agelenopsis aperta, is a potent and selective P/Q Ca2+ channel. type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings

with an IC50 of of 60 nM. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

ω-Conotoxin GVIA TFA ω-Conotoxin MVIIC Cat. No.: HY-P0189A Cat. No.: HY-P0188

ω-Conotoxin GVIA TFA is an inhibitor of the N-type ω-Conotoxin MVIIC is a N- and P/Q-type Ca2+ Ca2+ channel. channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release.

Purity: 99.03% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 1 mg, 5 mg

ω-Conotoxin MVIIC TFA Cat. No.: HY-P0188A

ω-Conotoxin MVIIC TFA is a N- and P/Q-type Ca2+ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release.

Purity: >98% Clinical Data: No Development Reported Size: 1 mg, 5 mg

24 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]