Eyelid and Tear Duct Disorders Cutting Edge Health Treatment
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12 Retina Gabriele K
299 12 Retina Gabriele K. Lang and Gerhard K. Lang 12.1 Basic Knowledge The retina is the innermost of three successive layers of the globe. It comprises two parts: ❖ A photoreceptive part (pars optica retinae), comprising the first nine of the 10 layers listed below. ❖ A nonreceptive part (pars caeca retinae) forming the epithelium of the cil- iary body and iris. The pars optica retinae merges with the pars ceca retinae at the ora serrata. Embryology: The retina develops from a diverticulum of the forebrain (proen- cephalon). Optic vesicles develop which then invaginate to form a double- walled bowl, the optic cup. The outer wall becomes the pigment epithelium, and the inner wall later differentiates into the nine layers of the retina. The retina remains linked to the forebrain throughout life through a structure known as the retinohypothalamic tract. Thickness of the retina (Fig. 12.1) Layers of the retina: Moving inward along the path of incident light, the individual layers of the retina are as follows (Fig. 12.2): 1. Inner limiting membrane (glial cell fibers separating the retina from the vitreous body). 2. Layer of optic nerve fibers (axons of the third neuron). 3. Layer of ganglion cells (cell nuclei of the multipolar ganglion cells of the third neuron; “data acquisition system”). 4. Inner plexiform layer (synapses between the axons of the second neuron and dendrites of the third neuron). 5. Inner nuclear layer (cell nuclei of the bipolar nerve cells of the second neuron, horizontal cells, and amacrine cells). 6. Outer plexiform layer (synapses between the axons of the first neuron and dendrites of the second neuron). -
Aafp Fmx 2020
10/7/2020 Common Acute Eye Presentations Dr. Ahmed Mian HonBSc, BEd, MD CCFP (EM) Staff ER Consultant Department of Emergency Medicine, Humber River Hospital and University Health Network Medical Director and Chair, Medical Education HRH ED Investigative Coroner, Province of Ontario Faculty DFCM/EM University of Toronto and DFM Queens' University 1 ACTIVITY DISCLAIMER The material presented here is being made available by the American Academy of Family Physicians for educational purposes only. Please note that medical information is constantly changing; the information contained in this activity was accurate at the time of publication. This material is not intended to represent the only, nor necessarily best, methods or procedures appropriate for the medical situations discussed. Rather, it is intended to present an approach, view, statement, or opinion of the faculty, which may be helpful to others who face similar situations. The AAFP disclaims any and all liability for injury or other damages resulting to any individual using this material and for all claims that might arise out of the use of the techniques demonstrated therein by such individuals, whether these claims shall be asserted by a physician or any other person. Physicians may care to check specific details such as drug doses and contraindications, etc., in standard sources prior to clinical application. This material might contain recommendations/guidelines developed by other organizations. Please note that although these guidelines might be included, this does not necessarily imply the endorsement by the AAFP. 2 2 1 10/7/2020 Disclosure It is the policy of the AAFP that all individuals in a position to control content disclose any relationships with commercial interests upon nomination/invitation of participation. -
Differentiate Red Eye Disorders
Introduction DIFFERENTIATE RED EYE DISORDERS • Needs immediate treatment • Needs treatment within a few days • Does not require treatment Introduction SUBJECTIVE EYE COMPLAINTS • Decreased vision • Pain • Redness Characterize the complaint through history and exam. Introduction TYPES OF RED EYE DISORDERS • Mechanical trauma • Chemical trauma • Inflammation/infection Introduction ETIOLOGIES OF RED EYE 1. Chemical injury 2. Angle-closure glaucoma 3. Ocular foreign body 4. Corneal abrasion 5. Uveitis 6. Conjunctivitis 7. Ocular surface disease 8. Subconjunctival hemorrhage Evaluation RED EYE: POSSIBLE CAUSES • Trauma • Chemicals • Infection • Allergy • Systemic conditions Evaluation RED EYE: CAUSE AND EFFECT Symptom Cause Itching Allergy Burning Lid disorders, dry eye Foreign body sensation Foreign body, corneal abrasion Localized lid tenderness Hordeolum, chalazion Evaluation RED EYE: CAUSE AND EFFECT (Continued) Symptom Cause Deep, intense pain Corneal abrasions, scleritis, iritis, acute glaucoma, sinusitis, etc. Photophobia Corneal abrasions, iritis, acute glaucoma Halo vision Corneal edema (acute glaucoma, uveitis) Evaluation Equipment needed to evaluate red eye Evaluation Refer red eye with vision loss to ophthalmologist for evaluation Evaluation RED EYE DISORDERS: AN ANATOMIC APPROACH • Face • Adnexa – Orbital area – Lids – Ocular movements • Globe – Conjunctiva, sclera – Anterior chamber (using slit lamp if possible) – Intraocular pressure Disorders of the Ocular Adnexa Disorders of the Ocular Adnexa Hordeolum Disorders of the Ocular -
Ciliary Zonule Sclera (Suspensory Choroid Ligament)
ACTIVITIES Complete Diagrams PNS 18 and 19 Complete PNS 23 Worksheet 3 #1 only Complete PNS 24 Practice Quiz THE SPECIAL SENSES Introduction Vision RECEPTORS Structures designed to respond to stimuli Variable complexity GENERAL PROPERTIES OF RECEPTORS Transducers Receptor potential Generator potential GENERAL PROPERTIES OF RECEPTORS Stimulus causing receptor potentials Generator potential in afferent neuron Nerve impulse SENSATION AND PERCEPTION Stimulatory input Conscious level = perception Awareness = sensation GENERAL PROPERTIES OF RECEPTORS Information conveyed by receptors . Modality . Location . Intensity . Duration ADAPTATION Reduction in rate of impulse transmission when stimulus is prolonged CLASSIFICATION OF RECEPTORS Stimulus Modality . Chemoreceptors . Thermoreceptors . Nociceptors . Mechanoreceptors . Photoreceptors CLASSIFICATION OF RECEPTORS Origin of stimuli . Exteroceptors . Interoceptors . Proprioceptors SPECIAL SENSES Vision Hearing Olfaction Gustation VISION INTRODUCTION 70% of all sensory receptors are in the eye Nearly half of the cerebral cortex is involved in processing visual information Optic nerve is one of body’s largest nerve tracts VISION INTRODUCTION The eye is a photoreceptor organ Refraction Conversion (transduction) of light into AP’s Information is interpreted in cerebral cortex Eyebrow Eyelid Eyelashes Site where conjunctiva merges with cornea Palpebral fissure Lateral commissure Eyelid Medial commissure (a) Surface anatomy of the right eye Figure 15.1a Orbicularis oculi muscle -
Novel Anterior Segment Phenotypes Resulting from Forkhead Gene Alterations: Evidence for Cross-Species Conservation of Function
Novel Anterior Segment Phenotypes Resulting from Forkhead Gene Alterations: Evidence for Cross-Species Conservation of Function Ordan J. Lehmann,1 Stephen Tuft,2 Glen Brice,3 Richard Smith,4 Åsa Blixt,5 Rachel Bell,3 Bengt Johansson,6 Tim Jordan,1 Roger A. Hitchings,2 Peng T. Khaw,2 Simon W. M. John,4 Peter Carlsson,5 and Shomi S. Bhattacharya1 PURPOSE. Mutations in murine and human versions of an ances- cause it may affect the clinical management of certain trally related gene usually result in similar phenotypes. How- glaucoma subtypes and lead to excessive treatment. The ever, interspecies differences exist, and in the case of two FOXC1 and Foxe3 data, taken together with the novel ocular forkhead transcription factor genes (FOXC1 and FOXC2), phenotypes of FOXC2 mutations, highlight the remarkable these differences include corneal or anterior segment pheno- cross-species conservation of function among forkhead genes. types, respectively. This study was undertaken to determine (Invest Ophthalmol Vis Sci. 2003;44:2627–2633) DOI:10.1167/ whether such discrepancies provide an opportunity for iden- iovs.02-0609 tifying novel human–murine ocular phenotypes. METHODS. Four pedigrees with early-onset glaucoma pheno- types secondary to segmental chromosomal duplications or ecognition that mutations in orthologous genes frequently deletions encompassing FOXC1 and 18 individuals from 9 Rcause similar phenotypes has allowed the field of compar- FOXC2 mutation pedigrees underwent detailed ocular pheno- ative genetics to contribute to the understanding of human typing. Subsequently, mice with mutations in Foxc1 or a re- disease. As the human, murine, and Drosophila PAX6 mutants lated forkhead gene, Foxe3, were assessed for features of the (aniridia, Small eye, and eyeless) demonstrate, genotypic con- human phenotypes. -
MOC PORT/DOCK Practice Core Modules Content Outline
MOC PORT/DOCK Practice Core Modules Content Outline 1 Cataract and Anterior Segment (10%) 1.1 Basic Anatomical and Scientific Aspects 1.1.1 The Normal Lens 1.1.1.1 Anatomy 1.2 Assessment Techniques 1.2.1 History-Taking and Preoperative Examination of Ocular Structures 1.2.1.1 Take patient history 1.2.1.2 Examine ocular structures 1.2.1.3 Signs and symptoms 1.2.1.4 Indications for surgery 1.2.1.6 External examination 1.2.1.7 Slit-lamp examination 1.2.1.8 Fundus evaluation 1.2.1.9 Impact on visual functioning and quality of life 1.2.2 Measurement of Visual and Macular Function 1.2.2.1 Visual acuity testing 1.2.2.2 Test visual acuity 1.2.2.5 Visual field testing 1.2.2.6 Test visual field 1.2.2.7 Cataract's effect on visual acuity 1.2.2.8 Estimate cataract's effect on visual acuity 1.2.2.10 Measure visual (and macular) function 1.2.4.3 Evaluate glare disability: subjective and objective 1.3 Clinical Disease Conditions and Manifestations 1.3.1 Types of Cataract 1.3.1.1 Identify types of cataracts 1.3.2 Anterior Segment Disorders 1.3.2.1 Diagnose anterior segment disorders 1.3.2.2 Cataract associated with uveitis 1.3.2.3 Diabetes mellitus and cataract formation 1.3.2.4 Lens-induced glaucoma 1.3.2.4.1 Lens particle 1.3.2.4.2 Phacolytic 1.3.2.4.3 Phacomorphic Copyright and Use Policy for ABO Content Outlines © 2017 – American Board of Ophthalmology. -
Adrenaline Dacryolith: Detection by Ultrasound Examination of the Nasolacrimal Duct
Br J Ophthalmol: first published as 10.1136/bjo.72.12.935 on 1 December 1988. Downloaded from British Journal ofOphthalmology, 1988, 72, 935-937 Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct JOHN A BRADBURY,' IAN G RENNIE,' AND M ANDREW PARSONS2 From the Departments of'Ophthalmology and 2Pathology, University ofSheffield SUMMARY A 73-year-old woman on topical pilocarpine and adrenaline for chronic simple glaucoma for three years presented with a mass in the medial canthus of the right eye. Although dacryocystography showed a dilated and partially obstructed nasolacrimal system, ultrasound examination was able to demonstrate a mass in the nasolacrimal duct. At operation a black dacryolith was found, of the diameter predicted by ultrasound. Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline. Ultrasound examination of the nasolacrimal drain- her right conjunctival sac. In between these acute age system has been shown to be of value when the episodes the epiphora and a slight swelling at the copyright. system is dilated in cases such as a mucocoele or acute medial canthus persisted but were less troublesome. dacryocystitis. It is of limited value in functional Her right nasolacrimal duct had been irrigated during disorders, where the passage of fluid through the one of these acute episodes, which had caused some nasolacrimal system is slowed, producing a minimally resolution of her symptoms. dilated system.' No reports so far have illustrated the On examination a firm mass was palpable over the ability of ultrasound to demonstrate a mass in the right lacrimal fossa extending slightly above the nasolacrimal duct. -
Distichiasis (Distichia)
DISTICHIASIS (DISTICHIA) What is distichiasis? Distichiasis is a common condition that affects dogs, and less commonly, cats. The normal eyelid margin is devoid of hairs. There are multiple glands (called meibomian glands) along the eyelids which produce an oily secretion. Occasionally a hair can arise from or near these glands and project out of the eyelid. This hair is called a distichium, and the plural is distichia. These hairs may or may not come in contact with the cornea. This depends on whether they are thick/stiff or fine, and in which direction they are growing (they may be directed inwards). What problems do they cause? Some distichia do not cause any problems. These are usually fine hairs, or hairs which are directed away from the cornea. Problems arise when the hairs rub on the cornea. It causes discomfort, and the animal may have a watery eye discharge and have excessive blinking. The hair can rub on the cornea and abrade it, causing a corneal ulcer. These corneal ulcers are very difficult to treat, as the hair continues to rub in the same area, preventing healing. Distichia grow in young dogs, and if they are going to cause a problem, they usually do so ion dogs of less than two years of age. However, occasionally they can become problematic in later life, particularly if the dog gets a condition called Dry Eye or keratoconjunctivitis sicca. In this condition, there is a deficiency in tears, making the eyes dry and more susceptible to the abrading effect of the distichia. How is distichiasis diagnosed? Distichia may be seen with the naked eye with very close inspection. -
Pediatric Orbital Tumors and Lacrimal Drainage System
Pediatric Orbital Tumors and Lacrimal Drainage System Peter MacIntosh, MD University of Illinois • No financial disclosures Dermoid Cyst • Congenital • Keratinized epidermis • Dermal appendage • Trapped during embryogenesis • 6% of lesions • 40-50% of orbital pediatric orbital lesion • Usually discovered in the first year of life • Painless/firm/subQ mass • Rarely presents as an acute inflammatory lesion (Rupture?) • Frontozygomatic (70%) • Maxillofrontal (20%) suture Imaging - CT • Erosion/remodeling of bone • Adjacent bony changes: “smooth fossa” (85%) • Dumbell dermoid: extraorbital and intraorbital components through bony defect Imaging - MRI • Encapsulated • Enhancement of wall but not lumen Treatment Options • Observation • Risk of anesthesia • Surgical Removal • Changes to bone • Rupture of cyst can lead to acute inflammation • Irrigation • Abx • Steroids Dermoid INFANTILE/Capillary Hemangioma • Common BENIGN orbital lesion of children • F>M • Prematurity • Appears in 1st or 2nd week of life • Soft, bluish mass deep to the eyelid • Superonasal orbit • Rapidly expands over 6-12 months • Increases with valsalva (crying) • Clinical findings • Proptosis Astigmatism • Strabismus Amblyopia INFANTILE/Capillary Hemangioma • May enlarge for 1-2 years then regress • 70-80% resolve before age 7 • HIGH flow on doppler • Kasabach-Merritt Syndrome • Multiple large visceral capillary hemangiomas • Sequestration of platelets into tumor • Consumptive thrombocytopenia • Supportive therapy and treat underlying tumor • Complications • DIC • death •Homogenous -
Stage Surgery on Inverted Papilloma Which Invaded Lacrimal Sac, Periorbita, Ethmoid and Frontal Sinus
臨床耳鼻:第 27 卷 第 1 號 2016 ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• J Clinical Otolaryngol 2016;27:143-147 증 례 Stage Surgery on Inverted Papilloma which Invaded Lacrimal Sac, Periorbita, Ethmoid and Frontal Sinus Jae-hwan Jung, MD, Minsic Kim, MD, Sue Jean Mun, MD and Hwan-Jung Roh, MD, PhD Department of Otorhinolaryngology-Head & Neck Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea - ABSTRACT - Inverted papilloma of the nasal cavity and the paranasal sinuses is a benign epithelial tumor with a high rate of recurrence, local aggressiveness, and malignant transformation. For these reasons, inverted papilloma has been treated like malignant tumors with extensive surgical resection. With the help of endoscopic sinus surgery tech- nique, it is now available to treat inverted papilloma with stage surgery without severe complications which usu- ally resulted from extensive one stage resection. We report a case of stage surgery on inverted papilloma which invaded lacrimal sac, periorbita, ethmoid and frontal sinus. (J Clinical Otolaryngol 2016;27:143-147) KEY WORDS:Inverted papillomaㆍLacrimal sacㆍPeriorbitaㆍSurgery. Authors present a successful endoscopic stage sur- Introduction gery on IP which invaded lacrimal sac, periorbita, ethmoid and frontal sinus with the literature review. Inverted papilloma (IP) of the nasal cavity and the paranasal sinuses is a benign epithelial tumor with a Case Report high rate of recurrence, local aggressiveness, and ma- lignant transformation.1,2) For these reasons, IP has A 41-year-old female presented in outpatient clinic been treated like malignant tumors with extensive sur- with a complaint of tender swelling mass on the in- gical resection. ner side of her right eye for 5 years which suddenly IP of lacrimal sac and periorbita is rarely reported aggravated 2 months ago. -
Canine Red Eye Elizabeth Barfield Laminack, DVM; Kathern Myrna, DVM, MS; and Phillip Anthony Moore, DVM, Diplomate ACVO
PEER REVIEWED Clinical Approach to the CANINE RED EYE Elizabeth Barfield Laminack, DVM; Kathern Myrna, DVM, MS; and Phillip Anthony Moore, DVM, Diplomate ACVO he acute red eye is a common clinical challenge for tion of the deep episcleral vessels, and is characterized general practitioners. Redness is the hallmark of by straight and immobile episcleral vessels, which run Tocular inflammation; it is a nonspecific sign related 90° to the limbus. Episcleral injection is an external to a number of underlying diseases and degree of redness sign of intraocular disease, such as anterior uveitis and may not reflect the severity of the ocular problem. glaucoma (Figures 3 and 4). Occasionally, episcleral Proper evaluation of the red eye depends on effective injection may occur in diseases of the sclera, such as and efficient diagnosis of the underlying ocular disease in episcleritis or scleritis.1 order to save the eye’s vision and the eye itself.1,2 • Corneal Neovascularization » Superficial: Long, branching corneal vessels; may be SOURCE OF REDNESS seen with superficial ulcerative (Figure 5) or nonul- The conjunctiva has small, fine, tortuous and movable vessels cerative keratitis (Figure 6) that help distinguish conjunctival inflammation from deeper » Focal deep: Straight, nonbranching corneal vessels; inflammation (see Ocular Redness algorithm, page 16). indicates a deep corneal keratitis • Conjunctival hyperemia presents with redness and » 360° deep: Corneal vessels in a 360° pattern around congestion of the conjunctival blood vessels, making the limbus; should arouse concern that glaucoma or them appear more prominent, and is associated with uveitis (Figure 4) is present1,2 extraocular disease, such as conjunctivitis (Figure 1). -
Familial Hypercholesterolemia and Xanthomatosis Associated with Diabetes Mellitus: a Case Report and Review of the Literature Ch
Familial Hypercholesterolemia and Xanthomatosis Associated with Diabetes Mellitus: A Case Report and Review of the Literature Ching-Hsiang Leung, Tien-Ling Chen*, Chao-Hung Wang, Kun-Wu Tsan, and Daniel T. H. Chin** Division of Endocrinology and Metabolism, Department of Internal Medicine; *Division of Allergy, Immunology & Rheumatology, Department of Internal Medicine; **Department of Pathology; Mackay Memorial Hospital, Taipei, Taiwan Abstract Familial hypercholesterolemia is an autosomal dominant disorder due to mutations in the low-density lipoprotein receptor gene, characterized by skin and tendon xanthomas, xanthelasma and premature arcus corneae. It is associated with an increased risk of premature coronary heart disease, which is further increased if there is co-existing diabetes mellitus. A 35-year-old female who developed cutaneous and tendon xanthomas since the age of 12 was diagnosed as having mixed primary familial hypercholesterolemia and secondary hyperlipidemia due to diabetes mellitus, and osteomyelitis. However, familial hypercholesterolemia remains seriously under-diagnosed, delaying treatment. Screening of first-degree relatives and extended family members plays an important role in early detection and treatment. ( J Intern Med Taiwan 2003;14:23-30 ) Key Words:Familial hypercholesterolemia, Xanthomatosis, Diabetes mellitus, LDL receptor, Osteomyelitis Introduction Familial hypercholesterolemia is a monogenic 1 , autosomal dominant 2 disorder due to mutations in the gene for the LDL receptor 3, characterized by xanthomas 4, xanthelasma and premature arcus corneae 5. Our report concerns a 35-year-old female patient who developed xanthomas since the age of 12 and was diagnosed as having mixed primary familial hypercholesterolemia and secondary hyperlipidemia due to diabetes mellitus, and osteomyelitis. The significance, characteristic features, diagnosis and treatment of familial hypercholesterolemia are discussed.