DOCSLIB.ORG

INFINITY PHARMACEUTICALS, INC. Form 8-K Current Event Report

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
INFINITY PHARMACEUTICALS, INC. Form 8-K Current Event Report SECURITIES AND EXCHANGE COMMISSION FORM 8-K Current report filing Filing Date: 2021-07-27 | Period of Report: 2021-07-27 SEC Accession No. 0001113148-21-000018 (HTML Version on secdatabase.com) FILER INFINITY PHARMACEUTICALS, INC. Mailing Address Business Address 1100 MASSACHUSETTS 1100 MASSACHUSETTS CIK:1113148| IRS No.: 330655706 | State of Incorp.:DE | Fiscal Year End: 1231 AVENUE AVENUE Type: 8-K | Act: 34 | File No.: 000-31141 | Film No.: 211115925 FLOOR 4 FLOOR 4 SIC: 2834 Pharmaceutical preparations CAMBRIDGE MA 02138 CAMBRIDGE MA 02138 6174531000 Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 27, 2021 Infinity Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 000-31141 33-0655706 (State or other jurisdiction (Commission File Number) (IRS Employer of incorporation) Identification No.) 1100 Massachusetts Avenue, Floor 4, Cambridge, MA 02138 (Address of principal executive offices) (Zip Code) Registrant’s telephone number, including area code: (617) 453-1000 Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: ☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) Securities registered pursuant to Section 12(b) of the Act: Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Title of Class Trading Symbol Name of Exchange on Which Registered Common Stock, $0.001 par value INFI Nasdaq Global Select Market Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨ Item 2.02. Results of Operations and Financial Condition. On July 27, 2021, Infinity Pharmaceuticals, Inc. (the “Company”) issued a press release announcing its results for the quarter ended June 30, 2021. A copy of this press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference. The information contained on the websites referenced in the press release is not incorporated herein. This information and Exhibit 99.1 hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended (the “Securities Act”), or the Exchange Act, except as expressly set forth by specific reference in such a filing. Item 7.01. Regulation FD Disclosure. On July 27, 2021, the Company intends to present a slide presentation on a conference call reviewing data from MARIO-275, the Company’s randomized, placebo-controlled Phase 2 clinical trial evaluating the efficacy and safety of eganelisib in combination with nivolumab (Opdivo®) in platinum-refractory, I/O naïve patients with advanced urothelial cancer, as well as data from MARIO-3, the Company’s Phase 2 clinical trial evaluating eganelisib in a triple combination in the front-line setting with Tecentriq® (atezolizumab) and Abraxane® (nab-paclitaxel) in patients with unresectable locally advanced or metastatic triple negative breast cancer. A copy of this slide presentation, dated July 27, 2021, is attached as Exhibit 99.2 to this Current Report on Form 8-K and is incorporated herein by reference. This information and Exhibit 99.2 hereto shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act or the Exchange Act, except as expressly set forth by specific reference in such a filing. Item 8.01. Other Events. On July 27, 2021, the Company issued a press release announcing data from MARIO-275 and MARIO-3 clinical trials. A copy of this press release is filed as Exhibit 99.3 to this Current Report on Form 8-K and is incorporated herein by reference. The information contained on websites referenced in the press release is not incorporated herein. *** Forward-Looking Statements This Current Report on Form 8-K and the exhibits attached hereto contain forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements that the Company makes due to a number of important factors, including those Risk Factors discussed in the Company’s annual and quarterly reports filed with the Securities and Exchange Commission (“SEC”), and its other filings with the SEC, available through the Company’s website at www.infi.com. Any forward-looking statements contained in Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document this Current Report on Form 8-K speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Item 9.01. Financial Statements and Exhibits. (d) Exhibits Exhibit No. Description 99.1 Press release dated July 27, 2021 99.2 Presentation dated July 27, 2021 99.3 Press release dated July 27, 2021 104 Cover Page Interactive Data File (embedded within the Inline XBRL document) Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. INFINITY PHARMACEUTICALS, INC. Date: July 27, 2021 By: /s/ Seth A. Tasker Seth A. Tasker Chief Business Officer Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Exhibit 99.1 Infinity Pharmaceuticals Reports Second Quarter 2021 Financial Results and Provides Company Update – New clinical data from MARIO-275 and MARIO-3 suggest that the addition of eganelisib to standard of care regimens provides patient benefit – – Increases seen in overall survival in 2L urothelial cancer (UC) and in progression free survival in 1L triple negative breast cancer (TNBC), in both cases regardless of PD-L1 status – – Stéphane Peluso, Ph.D., returns to Infinity as Chief Scientific Officer – – Cash balance of $97.3M to fund eganelisib development – – MARIO-275 and MARIO-3 data update on KOL webcast event today, 8:00AM ET – CAMBRIDGE, Mass., July 27, 2021 /Business Wire/ -- Infinity Pharmaceuticals, Inc. (NASDAQ: INFI) (“Infinity” or the “Company”), a clinical-stage biotechnology company developing eganelisib (IPI-549), a potentially first-in-class, oral, immuno-oncology macrophage reprogramming therapeutic, today announced its second quarter 2021 financial results and provided a corporate update. Adelene Perkins, Chief Executive Officer and Chair, Infinity Pharmaceuticals, said, “Today we report data indicating that eganelisib re- programs macrophages in the tumor microenvironment, turning pro-tumor, M2, macrophages into anti-tumor, M1, macrophages and improves outcomes for patients in two distinct types of cancer. Specifically, when combined with current standard of care therapies, the data showed that eganelisib increased overall survival in patients with metastatic urothelial cancer and prolonged progression free survival in patients with TNBC. These data provide preliminary, but compelling evidence of eganelisib’s potential to improve outcomes for patients with these two types of cancer. Validation of the fundamental biologic hypothesis of eganelisib, and the resulting prospect of patient benefit, gives us great confidence in the future of eganelisib, Infinity and our ability to realize our vision of bringing better therapies to patients. In the months ahead, Infinity plans to work with investigators, key opinion leaders and regulatory authorities to carefully choose the most appropriate clinical paths forward and expects to provide an update by year end, together with an update on our maturing TNBC data.” Ms. Perkins continued, “We’re thrilled to have Dr. Peluso return to Infinity in the role of Chief Scientific Officer during this exciting time for Infinity. Stéphane served as a valued member of Infinity’s
Load more

Recommended publications
  • PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects
    International Journal of Molecular Sciences Review PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects Rosalin Mishra , Hima Patel, Samar Alanazi , Mary Kate Kilroy and Joan T. Garrett * Department of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA; [email protected] (R.M.); [email protected] (H.P.); [email protected] (S.A.); [email protected] (M.K.K.) * Correspondence: [email protected]; Tel.: +1-513-558-0741; Fax: +1-513-558-4372 Abstract: The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian, colorectal, prostate, glioblastoma and endometrial cancers. PI3K signaling plays an important role in cancer cell survival, angiogenesis and metastasis, making it a promising therapeutic target. There are several ongoing and completed clinical trials involving PI3K inhibitors (pan, isoform-specific and dual PI3K/mTOR) with the goal to find efficient PI3K inhibitors that could overcome resistance to current therapies. This review focuses on the current landscape of various PI3K inhibitors either as monotherapy or in combination therapies and the treatment outcomes involved in various phases of clinical trials in different cancer types. There is a discussion of the drug-related toxicities, challenges associated with these PI3K inhibitors and the adverse events leading to treatment failure. In addition, novel PI3K drugs that have potential to be translated in the clinic are highlighted. Keywords: cancer; PIK3CA; resistance; PI3K inhibitors Citation: Mishra, R.; Patel, H.; Alanazi, S.; Kilroy, M.K.; Garrett, J.T.
    [Show full text]
  • Immunotherapy in Adrenocortical Carcinoma: Predictors of Response, Efficacy, Safety, and Mechanisms of Resistance
    biomedicines Review Immunotherapy in Adrenocortical Carcinoma: Predictors of Response, Efficacy, Safety, and Mechanisms of Resistance Marta Araujo-Castro 1,* , Eider Pascual-Corrales 1 , Javier Molina-Cerrillo 2 and Teresa Alonso-Gordoa 2 1 Neuroendocrinology Unit, Endocrinology and Nutrition Department, Ramón y Cajal Health Research Institute (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; [email protected] 2 Medical Oncology Department, Ramón y Cajal Health Research Institute (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; [email protected] (J.M.-C.); [email protected] (T.A.-G.) * Correspondence: [email protected] Abstract: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with limited treatment options in the advanced stages. Immunotherapy offers hope for altering the orthodox management of cancer, and its role in advanced ACC has been investigated in different studies. With the aim clarifying the role of immunotherapy in ACC we performed a comprehensive review about this topic focusing on the predictors of response, efficacy, safety, and the mechanisms of resistance. Five clinical trials with four immune checkpoint inhibitors (pembrolizumab, avelumab, nivolumab, and ipilimumab) have investigated the role of immunotherapy in advanced ACC. Despite, the different primary endpoints used in these studies, the reported rates of overall response rate and progression free survival were generally poor. Three main potential markers of response to immunotherapy Citation: Araujo-Castro, M.; in ACC have been described: Expression of PD-1 and PD-L1, microsatellite instability and tumor Pascual-Corrales, E.; Molina-Cerrillo, mutational burden. However, none of them has been validated in prospective studies. Several J.; Alonso-Gordoa, T.
    [Show full text]
  • 353 Safety and Efficacy of Tumor Infiltrating Lymphocytes (TIL, LN-145
    Abstracts J Immunother Cancer: first published as 10.1136/jitc-2020-SITC2020.0353 on 9 November 2020. Downloaded from Methods IPI-549-01 (NCT02637531) evaluates eganelisib in advanced solid tumors, as monotherapy and in combination with nivolumab. The combination expansion dose was eganeli- sib 40 mg QD PO + nivolumab 240 mg Q2W IV. Combina- tion expansion cohorts include SCCHN patients resistant to immediate prior anti-PD(L)1 therapy. Safety, preliminary clini- cal activity, PK, and correlative study of blood and tumor biopsy samples were mandated. Results As of June 1, 2020, 180 patients were treated with eganelisib + nivolumab including 21 with SCCHN.The most common (>20% of patients) treatment-emergent adverse Abstract 353 Figure 1 Iovance LN-145 (autologous TIL cell therapy events in patients treated with eganelisib + nivolumab (N = product) Manufacturing 180) were fatigue (34.4%), increased AST (30.0%), increased ALT (26.7%), nausea (25.0%), pyrexia (25.0%), anemia (22.8%), decreased appetite (20.6%), and cough (20.6%). 85 (47.2%) patients experienced at least 1 treatment-emergent serious adverse event (SAE) and 19 (10.6%) had a treatment- related SAE. There were no treatment-related grade 5 adverse events as assessed by investigators. Preliminary data from the SCCHN cohort show that in the efficacy-evaluable population which includes all patients (n=20) who had at least 1 post- baseline response assessment or discontinued treatment due to disease progression, the overall response rate (ORR, ie. CR Abstract 353 Figure 2 IOV-COM-202 Study Schema [complete response] or PR [partial response] per RECIST v1.1) is 10.0%, the disease control rate (DCR, ie.
    [Show full text]
  • Perspectives in Immunotherapy: Meeting Report from the Immunotherapy Bridge (December 2Nd–3Rd, 2020, Italy) Paolo A
    Ascierto et al. J Transl Med (2021) 19:238 https://doi.org/10.1186/s12967-021-02895-2 Journal of Translational Medicine MEETING REPORT Open Access Perspectives in immunotherapy: meeting report from the immunotherapy bridge (December 2nd–3rd, 2020, Italy) Paolo A. Ascierto1* , Carlo Bifulco2, Fortunato Ciardiello3, Sandra Demaria4,5,6, Leisha A. Emens7,8, Robert Ferris8, Silvia C. Formenti9, Jerome Galon10,11,12, Samir N. Khleif13, Tomas Kirchhof14, Jennifer McQuade15, Kunle Odunsi16,17, Akash Patnaik18, Chrystal M. Paulos19, Janis M. Taube20, John Timmerman21, Bernard A. Fox22, Patrick Hwu23 and Igor Puzanov24 Abstract Improved understanding of tumor immunology has enabled the development of therapies that harness the immune system and prevent immune escape. Numerous clinical trials and real-world experience has provided evidence of the potential for long-term survival with immunotherapy in various types of malignancy. Recurring observations with immuno-oncology agents include their potential for clinical application across a broad patient population with diferent tumor types, conventional and unconventional response patterns, durable responses, and immune-related adverse events. Despite the substantial achievements to date, a signifcant proportion of patients still fail to beneft from current immunotherapy options, and ongoing research is focused on transforming non-responders to respond- ers through the development of novel treatments, new strategies to combination therapy, adjuvant and neoadjuvant approaches, and the identifcation of biomarkers of response. These topics were the focus of the virtual Immunother- apy Bridge (December 2nd–3rd, 2020), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer and are summarised in this report.
    [Show full text]
  • Immunotherapy in the Treatment of Lymphoma
    World Journal of W J S C Stem Cells Submit a Manuscript: https://www.f6publishing.com World J Stem Cells 2021 June 26; 13(6): 503-520 DOI: 10.4252/wjsc.v13.i6.503 ISSN 1948-0210 (online) REVIEW Immunotherapy in the treatment of lymphoma Lazar S Popovic, Gorana Matovina-Brko, Maja Popovic, Milica Popovic, Ana Cvetanovic, Ivan Nikolic, Biljana Kukic, Dragana Petrovic ORCID number: Lazar S Popovic Lazar S Popovic, Maja Popovic, Ivan Nikolic, Biljana Kukic, Department for Medical Oncology, 0000-0002-3278-6875; Gorana Oncology Institute of Vojvodina, University of Novi Sad, Novi Sad 21000, Serbia Matovina-Brko 0000-0001-6491- 5953; Maja Popovic 0000-0002-1679- Gorana Matovina-Brko, Dragana Petrovic, Department for Medical Oncology, Oncology Institute 7144; Milica Popovic 0000-0002- of Vojvodina, Novi Sad 21000, Serbia 0124-9444; Ana Cvetanovic 0000- 0002-4113-9274; Ivan Nikolic 0000- Milica Popovic, Department for Nephrology and Clinical Immunology, Clinical Center of 0003-3023-6703; Biljana Kukic 0000- Vojvodina, University of Novi Sad, Novi Sad 21000, Serbia 0003-2044-9510; Dragana Petrovic 0000-0002-9370-6162. Ana Cvetanovic, Department for Medical Oncology, Clinical Center of Nis, University of Nis, Nis 18000, Serbia Author contributions: Popovic LS, Matovina-Brko G and Popovic Ma Corresponding author: Lazar S Popovic, MD, PhD, Professor, Department for Medical performed the literature research Oncology, Oncology Institute of Vojvodina, University of Novi Sad, Put dr Goldmana 4, Novi and wrote the manuscript; Popovic Sad 21000, Serbia. [email protected] LS, Matovina-Brko G and Popovic Ma, Popovic Mi, Cvetanovic A, Nikolic I, Kukic B, and Petrovic D Abstract analyzed the collected data; all Relapsed or refractory non-Hodgkin’s lymphomas, especially diffuse large B-cell authors have read and approved lymphoma as well as relapsed or refractory Hodgkin lymphomas are hard-to-treat the final manuscript.
    [Show full text]
  • Standard of Care and Promising New Agents for the Treatment of Mesenchymal Triple-Negative Breast Cancer
    cancers Review Standard of Care and Promising New Agents for the Treatment of Mesenchymal Triple-Negative Breast Cancer Silvia Mezi 1 , Andrea Botticelli 2, Giulia Pomati 3,*, Bruna Cerbelli 1, Simone Scagnoli 4 , Sasan Amirhassankhani 5, Giulia d’Amati 1 and Paolo Marchetti 2 1 Department of Radiological, Oncological and Pathological Science, University of Rome “Sapienza”, 00185 Rome, Italy; [email protected] (S.M.); [email protected] (B.C.); [email protected] (G.d.) 2 Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, 00185 Rome, Italy; [email protected] (A.B.); [email protected] (P.M.) 3 Department of Molecular Medicine, University of Rome “Sapienza”, 00185 Rome, Italy 4 Department of Medical and Surgical Sciences and Translational Medicine, University of Rome “Sapienza”, 00185 Rome, Italy; [email protected] 5 Department of Plastic Surgery, Guy’s & St Thomas’ NHS Foundation Trust, London SE1 7EH, UK; [email protected] * Correspondence: [email protected]; Tel.: +39-340-348-7850 Simple Summary: Mesenchymal triple negative breast cancer subtype expresses genes involved in proliferation, epithelial to mesenchymal transition, stromal interaction and cell motility. Moreover, this subgroup is characterized by an immunosuppressive microenvironment. This review focuses on the intracellular pathways involved in tumorigenesis and cancer progression, as well as in the immune evasion mechanisms. Furthermore, we provide an overview of current clinical trials investigating the efficacy and safety of different therapeutic molecules for this aggressive subtype Citation: Mezi, S.; Botticelli, A.; of triple negative breast cancer. The challenge is to restore immunocompetence by overcoming the Pomati, G.; Cerbelli, B.; Scagnoli, S.; chemo and immune-resistance profile of mesenchymal triple negative breast cancer to achieve a Amirhassankhani, S.; d’Amati, G.; lasting response to therapy.
    [Show full text]
  • Standard of Care and Promising New Agents for the Treatment of Mesenchymal Triple-Negative Breast Cancer
    cancers Review Standard of Care and Promising New Agents for the Treatment of Mesenchymal Triple-Negative Breast Cancer Silvia Mezi 1 , Andrea Botticelli 2, Giulia Pomati 3,*, Bruna Cerbelli 1, Simone Scagnoli 4 , Sasan Amirhassankhani 5, Giulia d’Amati 1 and Paolo Marchetti 2 1 Department of Radiological, Oncological and Pathological Science, University of Rome “Sapienza”, 00185 Rome, Italy; [email protected] (S.M.); [email protected] (B.C.); [email protected] (G.d.) 2 Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, 00185 Rome, Italy; [email protected] (A.B.); [email protected] (P.M.) 3 Department of Molecular Medicine, University of Rome “Sapienza”, 00185 Rome, Italy 4 Department of Medical and Surgical Sciences and Translational Medicine, University of Rome “Sapienza”, 00185 Rome, Italy; [email protected] 5 Department of Plastic Surgery, Guy’s & St Thomas’ NHS Foundation Trust, London SE1 7EH, UK; [email protected] * Correspondence: [email protected]; Tel.: +39-340-348-7850 Simple Summary: Mesenchymal triple negative breast cancer subtype expresses genes involved in proliferation, epithelial to mesenchymal transition, stromal interaction and cell motility. Moreover, this subgroup is characterized by an immunosuppressive microenvironment. This review focuses on the intracellular pathways involved in tumorigenesis and cancer progression, as well as in the immune evasion mechanisms. Furthermore, we provide an overview of current clinical trials investigating the efficacy and safety of different therapeutic molecules for this aggressive subtype Citation: Mezi, S.; Botticelli, A.; of triple negative breast cancer. The challenge is to restore immunocompetence by overcoming the Pomati, G.; Cerbelli, B.; Scagnoli, S.; chemo and immune-resistance profile of mesenchymal triple negative breast cancer to achieve a Amirhassankhani, S.; d’Amati, G.; lasting response to therapy.
    [Show full text]
  • Phosphoinositide 3-Kinase
    PI3K Phosphoinositide 3-kinase PI3K (Phosphoinositide 3-kinase), via phosphorylation of the inositol lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), forms the second messenger molecule phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) which recruits and activates pleckstrin homology domain containing proteins, leading to downstream signalling events crucial for proliferation, survival and migration. Class I PI3K enzymes consist of four distinct catalytic isoforms, PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ. There are three major classes of PI3K enzymes, being class IA widely associated to cancer. Class IA PI3K are heterodimeric lipid kinases composed of a catalytic subunit (p110α, p110β, or p110δ; encoded by PIK3CA, PIK3CB, and PIK3CD genes, respectively) and a regulatory subunit (p85). The PI3K pathway plays an important role in many biological processes, including cell cycle progression, cell growth, survival, actin rearrangement and migration, and intracellular vesicular transport. www.MedChemExpress.com 1 2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] PI3K Inhibitors, Activators & Modulators (+)-Nortrachelogenin (Rac)-AZD 6482 (Wikstromol) Cat. No.: HY-N3171A ((Rac)-KIN-193) Cat. No.: HY-75124 (+)-Nortrachelogenin (Wikstromol), a (Rac)-AZD 6482 ((Rac)-KIN-193) is the racemate of pharmacologically ligand from from wikstroemia AZD 6482. AZD 6482 is a potent and selective p110β indica, possesses antileukemic activity. inhibitor with an IC50 of 0.69 nM. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg (S)-PI3Kα-IN-4 1,3-Dicaffeoylquinic acid Cat.
    [Show full text]
  • PI3K/Akt/Mtor
    Inhibitors, Agonists, Screening Libraries www.MedChemExpress.com PI3K/Akt/mTOR The PI3K/Akt/mTOR signaling pathways is crucial to many aspects of cell growth and survival, in physiological as well as in pathological conditions. PI3Ks constitute a lipid kinase family. Class I PI3Ks are heterodimers composed of a catalytic (CAT) subunit (i.e., p110) and an adaptor/regulatory subunit (i.e., p85), and can be further divided into two subclasses: subclass IA (PI3Kα, β, and δ), which is activated by receptors with protein tyrosine kinase activity, and subclass IB (PI3Kγ), which is activated by receptors coupled with G proteins. Akt kinases belong to the AGC kinase family, related to AMP/GMP kinases and protein kinase C. mTOR is a key protein evolutionarily conserved from yeast to man and is essential for life. The mTORC1 complex is made up of mTOR, Raptor, mLST8, and PRAS40, and the mTORC2 complex is composed of mTOR, Rictor, Sin1, and mLST8. Upon ligand binding, phosphorylated tyrosine residing in activated RTKs will bind to p85, then release the catalytic subunit p110. Activated p110 phosphorylated the PIP2 into the second messenger PIP3, and this reaction can be reversed by the PI3K antagonist PTEN. PIP3 will recruit the downstream Akt to inner membranes and phosphorylates Akt on its serine/threonine kinase sites (Thr308 and Ser473). Activated Akt is involved in the downstream mTORC1 mediated response to biogenesis of protein and ribosome. Many genes belonging to the PI3K/Akt pathway have been implicated in the pathophysiology of solid tumors and sensitivity/resistance to chemotherapy. More and more studies are now focusing on the translational relevance of targeting these pathways in cancer therapy.
    [Show full text]
  • Arcus Biosciences Announces Third Quarter 2020 Financial Results and Corporate Updates
    NEWS RELEASE Arcus Biosciences Announces Third Quarter 2020 Financial Results and Corporate Updates 11/5/2020 - Commenced 10-year highly strategic partnership with Gilead to deliver next-generation cancer therapies - Recently announced collaboration with AstraZeneca for registrational trial, PACIFIC-8, further validates domvanalimab’s therapeutic potential - Signicant readouts from multiple studies expected in 2021 - Approximately $785 million of cash and funding into at least 2023 HAYWARD, Calif.--(BUSINESS WIRE)-- Arcus Biosciences, Inc. (NYSE:RCUS), an oncology-focused biopharmaceutical company working to create best-in-class cancer therapies, today announced nancial results for the third quarter ended September 30, 2020 and provided corporate updates. “Our progress in 2020 has signicantly de-risked the viability of Arcus’s ambitions to become a long-term independent biopharmaceutical company,” said Terry Rosen, Ph.D., CEO. “With the continued advancement of our four clinical-stage molecules, a landmark all-in collaboration with Gilead, a recently announced collaboration with AstraZeneca and approximately $785 million of cash on our balance sheet, we are well positioned to capitalize on the opportunities aorded by our pipeline. We expect 2021 to be a pivotal year for the company, with meaningful clinical readouts for all four of our clinical-stage molecules that should provide clear evidence of clinical benet, as well as the start of a registrational trial that is designed to support the potential approval of both zimberelimab monotherapy and domvanalimab in combination with zimberelimab. In 2021, we also expect to further expand our 1 clinical pipeline with IND lings in the second half of the year for our rst two small molecules active against cancer cell-intrinsic targets.” Key Corporate Highlights Commenced our 10-year partnership with Gilead to co-develop and co-commercialize next-generation cancer immunotherapies.
    [Show full text]
  • 2020 Medicines in Development ꟷ Cancer
    2020 Medicines in Development ꟷ Cancer Product Name Sponsor Indication Development Status 177-Lu-edotretide ITM Solucin neuroendocrine tumors Phase III (peptide receptor radionucleotide Munich, Germany www.itm-radiopharm.com therapy) 177-Lu-NeoB Advanced Accelerator Applications solid tumors Phase I (radioligand therapy target GRPR) Millburn, NJ www.adacap.com 177-Lu-PSMA-617 Advanced Accelerator Applications metastatic castration-resistant Phase III (targeted radioligand therapy) Millburn, NJ prostate cancer www.adacap.com 177-Lu-PSMA-R2 Advanced Accelerator Applications prostate cancer Phase I (radioligand therapy target PSMA) Millburn, NJ www.adacap.com 2X-121 Oncology Venture US metastatic breast cancer, Phase II (PARP inhibitor) Scottsdale, AZ advanced ovarian cancer www.oncologyventure.com 609A 3SBio solid tumors Phase I (anti-PD1 antibody) Shenyang, China www.3sbio.com 67Cu-SARTATE™ Clarity Pharmaceuticals neuroblastoma Phase I/II (peptide receptor radionuclide Sydney, Australia www.claritypharmaceuticals.com therapy) Medicines in Development: Cancer ǀ 2020 1 Product Name Sponsor Indication Development Status 7HP349 7 Hills Pharma solid tumors Phase I (VLA-4/LFA-1 activator) Houston, TX www.7hillspharma.com 9-ING-41 Actuate Therapeutics myelofibrosis Phase II (GSK-3β inhibitor) Fort Worth, TX www.actuatetherapeutics.com ORPHAN DRUG advanced cancers, Phase I refractory malignancies (pediatric) www.actuatetherapeutics.com A166 KLUS Pharma HER2-expressing solid tumors Phase I (antibody-drug conjugate) Cranbury, NJ www.kluspharma.com
    [Show full text]
  • Anti-COVID-19 Compound Library (96-Well)
    • Bioactive Molecules • Building Blocks • Intermediates www.ChemScene.com Anti-COVID-19 Compound Library (96-well) Product Details: Catalog Number: CS-L052 Formulation: A collection of 1512 compounds that may have anti-COVID-19 activity supplied as pre-dissolved Solutions or Solid Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode Storage: -80°C Shipping: Blue ice Packaging: Inert gas Plate layout: CS-L052-1 1 2 3 4 5 6 7 8 9 10 11 12 Varenicline a Empty Vonoprazan Faropenem Flavopiridol Semagacesta Delpazolid DSM265 GSK- Varenicline (Hydrochlorid Varenicline Empty daloxate t 2881078 e) (Tartrate) AQ-13 b Empty dihydrochlorid Linaprazan BFH772 Cadazolid Treprostinil Paquinimod AEE788 Plerixafor GSK2256098 Aprepitant Empty e c Empty Flopropione Acriflavine Spiramycin Ticagrelor Axitinib Eganelisib HT-2157 CXD101 Ritlecitinib 3-AP Empty TAK-659 (2- d Empty BGP-15 (hydrochlorid Navitoclax Acelarin Olcegepant Sarcosine Hydroxypropy TG100-115 T807 JNJ- Empty e) l)-β- 39758979 Veliparib e Empty Asenapine Silodosin Barasertib- Barasertib Vadadustat Veliparib Iberdomide (dihydrochlori Ralfinamide Zanubrutinib Empty HQPA de) Ibuprofen f Empty piconol Avapritinib GSK3326595 Roblitinib Gefapixant Tozasertib Olaparib GSK2982772 Ziritaxestat Dasatinib Empty Dasatinib g Empty (hydrochlorid TG 100801 Miridesap Linsitinib Sepantronium Prostaglandin Navarixin AZD4635 Rucaparib Sorafenib Empty e) (bromide) E2 (Camsylate) Sorafenib h Empty (Tosylate) Cediranib Apimostinel Pazopanib
    [Show full text]