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Table of Contents Cancer Research Table of Contents October 15, 2019 Volume 79 Number 20 BREAKING INSIGHTS 5159 ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma 5129 Highlights from Recent Cancer Literature Hanna Foster, E. Josue Ruiz, Christopher Moore, Gordon W.H. Stamp, Emma L. Nye, Ningning Li, Yihang Pan, Yulong He, Julian Downward, and Axel Behrens REVIEWS Significance: These findings identify ATMIN as a tumor suppressor in LUAD; fragility at chr16q23 correlates with 5131 Roles and Regulation of Long Noncoding RNAs loss of ATMIN in human LUAD and deletion of Atmin in Hepatocellular Carcinoma increases tumor burden in a LUAD mouse model. Lee Jin Lim, Samuel Y.S. Wong, Feiyang Huang, Sheng Lim, Samuel S. Chong, London Lucien Ooi, Oi Lian Kon, and Caroline G. Lee GENOME AND EPIGENOME 5140 Value of Collaboration among Multi-Domain 5167 Identification of Coding and Long Noncoding Experts in Analysis of High-Throughput RNAs Differentially Expressed in Tumors and Genomics Data Preferentially Expressed in Healthy Tissues Daoud Meerzaman and Barbara K. Dunn Juan P. Unfried, Guillermo Serrano, Beatriz Suarez, Comparing healthy tissues and tumor samples reveals that the testis and brain are the major tissues that preferentially express relevant RNAs upregulated in tumors. © 2019 American Association for Cancer Research Paloma Sangro, Valeria Ferretti, Celia Prior, Loreto Boix, Jordi Bruix, Bruno Sangro, Víctor Segura, and Puri Fortes CANCER RESEARCH HIGHLIGHTS Significance: Comprehensive analysis of coding and noncoding genes expressed in different tumors and normal 5146 Targeting Semaphorin 4D in Cancer: A Look from tissues, which should be taken into account to predict side Different Perspectives effects from potential coding and noncoding gene-targeting Luca Tamagnone and Giulia Franzolin therapies. See related article, p. 5328 5181 Banding Together: A Systematic Comparison of 5149 Stearoyl CoA Desaturase Regulates Ferroptosis in The Cancer Genome Atlas and the Mitelman Ovarian Cancer Offering New Therapeutic Databases Perspectives Connor Denomy, Samuel Germain, Bjorn Haave, Michele Carbone and Gerry Melino Frederick S. Vizeacoumar, Andrew Freywald, Beth A. Weaver, and Franco J. Vizeacoumar See related article, p. 5355 Significance: A novel in silico approach compares cytogenetic data between the Mitelman database and TCGA, PRIORITY REPORT highlighting the advantages and limitations of both datasets. 5151 miR-221 Targets QKI to Enhance the Tumorigenic METABOLISM AND CHEMICAL BIOLOGY Capacity of Human Colorectal Cancer Stem Cells Junko Mukohyama, Taichi Isobe, Qingjiang Hu, 5191 Targeting Myeloperoxidase Disrupts Takanori Hayashi, Takashi Watanabe, Masao Maeda, Mitochondrial Redox Balance and Overcomes Hisano Yanagi, Xin Qian, Kimihiro Yamashita, Cytarabine Resistance in Human Acute Myeloid Hironobu Minami, Koshi Mimori, Debashis Sahoo, Leukemia Yoshihiro Kakeji, Akira Suzuki, Piero Dalerba, and Mohsen Hosseini, Hamid Reza Rezvani, Nesrine Aroua, Yohei Shimono Claudie Bosc, Thomas Farge, Estelle Saland, Significance: These findings uncover molecular Veronique Guyonnet-Duperat, Sonia Zaghdoudi, mechanisms underlying the maintenance of cancer stem Latifa Jarrou, Clement Larrue, Marie Sabatier, cell properties in colon cancer. Pierre Luc Mouchel, Mathilde Gotanegre, Marc Piechaczyk, Guillaume Bossis, Christian Recher, and Jean-Emmanuel Sarry Significance: These findings demonstrate the role of myeloperoxidase in the regulation of ROS levels and sensitivity of AML cells to cytarabine, an essential chemotherapeutic backbone in the therapy of AML. v Downloaded from cancerres.aacrjournals.org on September 27, 2021. © 2019 American Association for Cancer Research. Table of Contents MOLECULAR CELL BIOLOGY 5272 Serine-Phosphorylated STAT3 Promotes Tumorigenesis via Modulation of RNA 5204 SF3B2-Mediated RNA Splicing Drives Human Polymerase Transcriptional Activity Jesse J. Balic, Daniel J. Garama, Mohamed I. Saad, General RNA splicing SF3B2 complex-mediated alternative RNA splicing Prostate Cancer Progression U2 U2 snRNA 3’ 3’ 5’ 3’ splice site 5’ SF3B7 5’ A U2AF2 AGA Exon ? SF3B6(p14) SF3B4 SF3B1 SF3B4 SF3B1 SF3B5 Liang Yu, Alison C. West, Alice J. West, Thaleia Livis, SF3B2 SF3B3 SF3B2 SF3B3 SF3A3 SF3B2 complex SF3A3 SF3A1 SF3A1 SF3b complex AR pre-mRNA Norihiko Kawamura, Keisuke Nimura, Kotaro Saga, CE3 AR-V7 mRNA AR mRNA CE3 Drive malignancy While the SF3b complex is critical for general RNA splicing, SF3B2 promotes inclusion of the target exon through recognizing a specific RNA motif. Prithi S. Bhathal, Daniel J. Gough, and Brendan J. Jenkins © 2019 American Association for Cancer Research Airi Ishibashi, Koji Kitamura, Hiromichi Nagano, Yusuke Yoshikawa, Kyoso Ishida, Norio Nonomura, Significance: These findings reveal a new transcriptional Mitsuhiro Arisawa, Jun Luo, and Yasufumi Kaneda role and mandatory requirement for constitutive STAT3 Significance: RNA splicing factor SF3B2 is essential for the serine phosphorylation in gastric cancer. generation of an androgen receptor (AR) variant that renders prostate cancer cells resistant to AR-targeting 5288 SRSF3-Regulated RNA Alternative Splicing therapy. Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes Xiao Song, Xuechao Wan, Tianzhi Huang, Chang Zeng, 5218 Mitochondrial NIX Promotes Tumor Survival Namratha Sastry, Bingli Wu, C. David James, in the Hypoxic Niche of Glioblastoma Craig Horbinski, Ichiro Nakano, Wei Zhang, Bo Hu, Jinkyu Jung, Ying Zhang, Orieta Celiku, Wei Zhang, and Shi-Yuan Cheng Hua Song, Brian J. Williams, Amber J. Giles, Jeremy N. Rich, Roger Abounader, Mark R. Gilbert, and Significance: SRSF3 is a significant regulator of Deric M. Park glioma-associated alternative splicing, implicating SRSF3 as an oncogenic factor that contributes to the Significance: NIX-mediated mitophagy regulates tumor tumor biology of GBM. survival in the hypoxic niche of glioblastoma microenvironment, providing a potential therapeutic target for glioblastoma. TUMOR BIOLOGY AND IMMUNOLOGY 5233 Phosphorylation of HSF1 by PIM2 Induces 5302 PD-L1 Expression and Promotes Tumor The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Growth in Breast Cancer High dose Moderate dose Just Right Lymphodepleting Tingting Yang, Chune Ren, Chao Lu, Pengyun Qiao, chemotherapy Low dose Tolerized cells Effector T cells Regulatory T cells Tumor cells Derek S. Park, Mark Robertson-Tessi, Kimberly A. Luddy, Moderate chemotherapy dosing can lead to optimal outcomes through balancing cytotoxicity with preserving immune state to support a long-term antitumor T-cell response. Xue Han, Li Wang, Dan Wang, Shijun Lv, Yonghong Sun, © 2019 American Association for Cancer Research Philip K. Maini, Michael B. Bonsall, Robert A. Gatenby, and Zhenhai Yu and Alexander R.A. Anderson Significance: These findings identify heat shock Significance: To maximize the synergy between transcription factor 1 as a new substrate for PIM2 kinase chemotherapy and antitumor immune response, and establish its role in breast tumor progression. lymphodepleting therapy must be balanced in a "Goldilocks Window" of optimal dosing. 5245 CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell 5316 Prolactin Promotes Fibrosis and Pancreatic Survival Cancer Progression Laia Martínez-Carreres, Julien Puyal, Manuj Tandon, Gina M. Coudriet, Angela Criscimanna, Lucía C. Leal-Esteban, Meritxell Orpinell, Mairobys Socorro, Mouhanned Eliliwi, Aatur D. Singhi, Judit Castillo-Armengol, Albert Giralt, Oleksandr Dergai, Zobeida Cruz-Monserrate, Peter Bailey, Michael T. Lotze, Catherine Moret, Valentin Barquissau, Anita Nasrallah, Herbert Zeh, Jing Hu, Vincent Goffin, George K. Gittes, Angelique Pabois, Lianjun Zhang, Pedro Romero, Andrew V. Biankin, and Farzad Esni Isabel C. Lopez-Mejia, and Lluis Fajas Significance: Prolactin is a key factor in the cross-talk Significance: These findings uncover a novel function of between the stroma and neoplastic epithelium, functioning to CDK4 in lysosomal biology, which promotes cancer promote fibrosis and PDAC progression. progression by activating mTORC1; targeting this function offers a new therapeutic strategy for cancer treatment. 5328 Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Binding of the vascular-targeting agent anti-Sema4D to Sema4D on macrophages promotes a malignant phenotype via SDF1/CXCR4 signaling. 5260 ZBTB7A Mediates the Transcriptional Repression © 2019 American Association for Cancer Research Mechanism of Vascular-Targeting Agents Activity of the Androgen Receptor in Prostate Iratxe Zuazo-Gaztelu, Marta Paez-Ribes, Patricia Carrasco, Cancer Laura Martín, Adriana Soler, Mar Martínez-Lozano, Dong Han, Sujun Chen, Wanting Han, Shuai Gao, Roser Pons, Judith Llena, Luis Palomero, Jude N. Owiredu, Muqing Li, Steven P. Balk, Mariona Graupera, and Oriol Casanovas Housheng Hansen He, and Changmeng Cai Significance: An anti-semaphorin-4D vascular Significance: ZBTB7A is recruited to the E2F-Rb binding targeting agent demonstrates antitumor and prosurvival sites by AR and negatively regulates the transcriptional effects but also unravels a novel promalignant effect involving activity of E2F1 on DNA replication genes. macrophage-derived SDF1 that promotes tumor invasion and metastasis, both in animal models and patients. See related commentary, p. 5146 vi Downloaded from cancerres.aacrjournals.org on September 27, 2021. © 2019 American Association for Cancer Research. Table of Contents 5342 Heparanase Accelerates
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