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Home , Azelnidipine, Calcium channel blocker, Carboxyamidotriazole, Channel modulator, Darodipine, Efonidipine

Calcium Channel Ca2+ channels;Ca channels

Calcium channel is an which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca 2+ into cells despite a 70-fold higher extracellular concentration of Na +. Some calcium channel blockers have the added benefit of slowing your rate, which can further reduce pressure, relieve () and control an irregular heartbeat.

www.MedChemExpress.com 1 Calcium Channel Inhibitors & Modulators

(+)- ABT-639 Cat. No.: HY-B1671 Cat. No.: HY-19721

Bioactivity: (+)-Kavain, a main kavalactone extracted from Piper Bioactivity: ABT-639 is a novel, peripherally acting, selective T-type methysticum, has anticonvulsive properties, attenuating Ca2+ . vascular contraction through interactions with voltage-dependent Na + and Ca 2+ channels [1]. (+)-Kav…

Purity: 99.98% Purity: 99.15% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

ABT-639 hydrochloride chloride Cat. No.: HY-101616 (Ach; ACh chloride) Cat. No.: HY-B0282

Bioactivity: ABT-639 hydrochloride is a novel, peripherally acting, Bioactivity: Acetylcholine (chloride) is a common found selective T-type Ca2+ channel blocker. in the central and peripheral nerve system.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

ACT-709478 AE0047 Hydrochloride Cat. No.: HY-112723 Cat. No.: HY-U00284

Bioactivity: ACT-709478 is a potent, selective, orally active, and brain Bioactivity: AE0047 Hydrochloride is a calcium blocker, used in the penetrating T-type . ACT-709478 is used research of hypertensive disease. in the research of generalized [1].

Purity: 99.68% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Amlodipine besylate Cat. No.: HY-B0317 (Amlodipine benzenesulfonate) Cat. No.: HY-B0317B

Bioactivity: Amlodipine is a long-acting calcium channel blocker. Bioactivity: Amlodipine besylate is a long-acting calcium channel blocker.

Purity: 99.57% Purity: 98.21% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g

Amlodipine maleate Cat. No.: HY-B0317A Cat. No.: HY-U00044

Bioactivity: Amlodipine maleate is a long-acting calcium channel blocker. Bioactivity: Anipamil is a long-acting calcium channel blocker, used for the treatment of cardiovascular disease.

Purity: 99.87% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 1 g, 5 g

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Aranidipine (MPC1304) Cat. No.: HY-U00212 (CS 905) Cat. No.: HY-B0023

Bioactivity: (MPC1304) is a Ca2+ channel antagonist with Bioactivity: Azelnidipine(CS 905; Calblock) is a novel dihydropyridine potent and long-lasting antihypertensive effects. derivative, a L-type calcium channel blocker, and an antihypertensive.

Purity: >98% Purity: 99.35% Clinical Data: Launched Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Azelnidipine D7 Bay-K-8644 ((R)-(+)-) (CS-905 D7) Cat. No.: HY-B0023S ((R)-(+)-Bay-K-8644; R-4407; NI-105; (+)-BAY-K-8644) Cat. No.: HY-15125

Bioactivity: Azelnidipine D7 is deuterium labeled Azelnidipine, which is a Bioactivity: Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. L-type calcium channel blocker. 2+ Bay-K-8644 (R)-(+)- inhibits Ba currents ( IBa) ( IC50=975 nM).

Purity: >98% Purity: 98.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Bay-K-8644 ((S)-(-)-) hydrochloride ((S)-(-)-Bay-K-8644; (-)-BAY-R-5417; (-)-BAY-K-8644) Cat. No.: HY-15124 (KW-3049) Cat. No.: HY-B1448

Bioactivity: Bay-K-8644 (S)-(-)- is an of L-type Ca2+ channel. Bioactivity: Benidipine hydrochloride is a dihydropyridine calcium channel blocker for the treatment of high Bay-K-8644 (S)-(-)- activates Ba 2+ currents ( I ) ( Ba (). EC50=32 nM).

Purity: 98.34% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg

Bepridil hydrochloride Ca2+ channel agonist 1 (CERM 1978) Cat. No.: HY-103315 Cat. No.: HY-41076

Bioactivity: hydrochloride (CERM 1978) is a calcium channel Bioactivity: Ca 2+ channel agonist 1 is an agonist of N-type Ca2+ channel blocker, with activity. and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. Purity: 99.76% Purity: 99.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg

Calcium channel inhibitor 1 Calcium channel-modulator-1 Cat. No.: HY-101096 Cat. No.: HY-U00135

Bioactivity: Calcium channel inhibitor 1 (compound 33) is a potent and Bioactivity: Calcium channel-modulator-1 is a calcium ;

selective inhibitor of the T-type calcium channel. blocks aortic contraction with an IC50 of 0.8 μM.

Purity: 99.82% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

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Carboxyamidotriazole Cav 2.2 blocker 1 (L 651582; CAI) Cat. No.: HY-16126 Cat. No.: HY-119373

Bioactivity: (L 651582; CAI) is a blocker of Bioactivity: Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel [1] non-voltage dependent calcium channel . (Cav 2.2) blocker for the treatment of pain, with an IC50 of Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic 1 nM [1]. anti-tumor , which also shows anti-inflammatory activ…

Purity: 99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 100 mg, 500 mg, 250 mg

CDN1163 Cat. No.: HY-101455 (FRC-8653) Cat. No.: HY-17404

Bioactivity: CDN1163 is a sarco/endoplasmic reticulum Ca2+-ATPase ( Bioactivity: Cilnidipine(FRC8653) is a dual L- and N-type calcium channel SERCA) activator. blocker and displays antihypertensive, sympatholytic and neuroprotective activity.

Purity: 99.12% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Cinnarizine Cat. No.: HY-B1090 Cat. No.: HY-17436

Bioactivity: is an and a calcium channel blocker, Bioactivity: Clevidipine is a short-acting dihydropyridine calcium channel promote cerebral blood flow, used to treat cerebral apoplexy, antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development post-trauma cerebral symptoms, and cerebral arteriosclerosis. for treatment of perioperative hypertension. IC50 Value: 7.1 nM at V(H) = -40 mV [1] Target: calcium channel in vitro: Both clevidipine and completely reversed… Purity: 98.0% Purity: 99.74% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 50 mg, 100 mg

CP-060 Cromolyn sodium Cat. No.: HY-U00354 (Disodium Cromoglycate; FPL-670) Cat. No.: HY-B0320A

Bioactivity: CP-​060 is a potent Ca2+ antagonist, inhibits Ca 2+ Bioactivity: Cromolyn (sodium) is an antiallergic drug. overload and possesses antioxidant and cardioprotective activities.

Purity: >98% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in Water, 1 g, 5 g

CV-159 sodium Cat. No.: HY-19025 (F 440) Cat. No.: HY-14657

Bioactivity: CV-159 is a unique dihydropyridine Ca2+ antagonist with an Bioactivity: Dantrolene sodium is a inhibitor of calcium channel proteins, anti- (CaM) action, and has antiinflammatory inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene activities. sodium is a skeletal which acts by blocking beyond the neuromuscular junction.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 100 mg, 500 mg

4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Cat. No.: HY-12542A (PY 108-068; PY-108068) Cat. No.: HY-U00086

Bioactivity: Dantrolene sodium hemiheptahydrate is a Bioactivity: Darodipine (PY 108-068, PY-108068) is a potent calcium relaxant which acts by blocking muscle contraction beyond the channel antagonist. neuromuscular junction. Dantrolene sodium hemiheptahydrate is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 100 mg, 200 mg, 500 mg

Dehydronitrosonisoldipine DHBP dibromide Cat. No.: HY-Z0816 (Diheptylviologen dibromide) Cat. No.: HY-101237

Bioactivity: Dehydronitrosonisoldipine is a calcium channel antagonist. Bioactivity: DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

Purity: 98.79% Purity: 99.56% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg 100 mg

Diltiazem hydrochloride Dopropidil (CRD-401) Cat. No.: HY-14656 Cat. No.: HY-U00151

Bioactivity: hydrochloride is a Ca2+ influx inhibitor (slow Bioactivity: Dopropidil is a novel anti-anginal calcium ion modulating channel blocker or calcium antagonist). agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.

Purity: 98.39% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g, 5 g

Efonidipine hydrochloride (NZ-105; (±)-Efonidipine) Cat. No.: HY-12502 (NZ-105 hydrochloride) Cat. No.: HY-12502B

Bioactivity: Efonidipine(NZ-105) is a dual T-type and L-type calcium Bioactivity: Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB). IC50 value: Target: calcium channel channel blocker (CCB). blocker in vitro: Efonidipine and , but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate… Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10 mg, 50 mg

Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) Cat. No.: HY-12502A Cat. No.: HY-B1378

Bioactivity: Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride Bioactivity: Ethosuximide, a widely prescribed anti-epileptic drug, monoethanolate) is a dual T-type and L-type calcium channel improves the phenotypes of multiple neurodegenerative disease blocker (CCB). IC50 value: Target: calcium channel blocker in models and blocks the low voltage activated T-type calcium vitro: Efonidipine and nifedipine, but not other examined channel. CCBs, also increased the N(6), 2'-O-dibutyryladenosine… Purity: 99.83% Purity: 99.54% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 500 mg

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Etiracetam Etripamil (UCB 6474) Cat. No.: HY-B0106A (MSP-2017; (-)-MSP-2017) Cat. No.: HY-17611

Bioactivity: Etiracetam (UCB 6474) is an acetylcholine agonist and a Bioactivity: Etripamil (MSP-2017) is a short-acting L-type drug of the racetam family. Less active than its calcium-channel antagonist with a rapid onset of action S-enantiomer (UCB L059) [1]. designed for intranasal administration, used to treat Paroxysmal Supraventricular (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and… Purity: 99.91% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 50 mg

Fantofarone (SR 33557) Cat. No.: HY-105117 (HA-1077; AT877) Cat. No.: HY-10341A

Bioactivity: is a highly potent Calcium Channel antagonist. Bioactivity: Fasudil (HA-1077; AT877), a potent inhibitor of ROCK with a 2+ Ki of 0.33 μM for ROCK1, which is also a potent Ca channel antagonist and vasodilator.

Purity: 98.56% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 200 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

Fasudil Hydrochloride (HA-1077 (Hydrochloride); AT-877 (Hydrochloride)) Cat. No.: HY-10341 Cat. No.: HY-B0309

Bioactivity: Fasudil Hydrochloride (HA-1077 Hydrochloride; AT-877 Bioactivity: Felodipine is a long-acting 1,4-dihydropyridine calcium

Hydrochloride), a potent inhibitor of ROCK with a Ki of 0.33 channel blocker. Target: Calcium Channel Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker μM for ROCK1, which is also a potent Ca2+ channel antagonist (CCB)b. It acts primarily on cells by and vasodilator. stabilizing voltage-gated L-type calcium channels in their… Purity: 99.91% Purity: 99.75% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 200 mg, 500 mg 10 mg, 50 mg

Fendiline hydrochloride Cat. No.: HY-B0984 Cat. No.: HY-B1221

Bioactivity: is a nonselective calcium channel blocker. Bioactivity: Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase ( COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channel…

Purity: 99.98% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

Flunarizine dihydrochloride Cat. No.: HY-B0358A (R 6218; Redeptin) Cat. No.: HY-B1655

Bioactivity: is a selective calcium entry blocker. Bioactivity: Fluspirilene is a non-competitive antagonist of L-type

calcium channels with an IC50 of 0.03 μM. Fluspirileneis a long-acting injectable depot drug used for schizophrenia.

Purity: 99.76% Purity: 99.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg 500 mg

6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Gabapentin enacarbil Cat. No.: HY-A0057 (XP-13512) Cat. No.: HY-16216

Bioactivity: Gabapentin (Neurontin) is a pharmaceutical drug, specifically Bioactivity: (XP-13512) is a prodrug for the a GABA analog. It was originally developed to treat , and drug gabapentin. and currently is also used to relieve . IC50 Value: 140 nM (α2δ subunit of calcium channel) [1] Target: Calcium Channel in vitro: Gabapentin, and CGP 44532… Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 5 mg, 10 mg 10 mg, 50 mg, 100 mg

Gabapentin hydrochloride Ginsenoside Rd Cat. No.: HY-A0057A (Gypenoside VIII) Cat. No.: HY-N0043

Bioactivity: Gabapentin (Neurontin) is a pharmaceutical drug, specifically Bioactivity: Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional a GABA analog. It was originally developed to treat epilepsy, activity with an IC50 of 12.05±0.82 μM in HepG2 cells. and currently is also used to relieve neuropathic pain. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside… Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg

Ginsenoside Rf Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; (Panaxoside Rf) Cat. No.: HY-N0601 Chikusetsusaponin V) Cat. No.: HY-N0607

Bioactivity: Ginsenoside Rf is a trace component of ginseng root. Bioactivity: Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Ginsenoside Rf inhibits N-type Ca2+ channel. Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet

effect with an IC 50 of 155 μM. Ginsenoside Ro reduces the

production of TXA2 more than it reduces the activities… Purity: 94.90% Purity: 98.69% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg

GSK-7975A GV-58 Cat. No.: HY-12507 Cat. No.: HY-12498

Bioactivity: GSK-7975A is a potent and orally available CRAC channel Bioactivity: GV-58 is a potent, selective N- and P/Q-type Ca2+ channels inhibitor. agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity.

Purity: 99.56% Purity: 99.09% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg

Ibutilide fumarate Iganidipine (U70226E) Cat. No.: HY-B0387 Cat. No.: HY-101685

Bioactivity: Fumarate is a Class III that is Bioactivity: Iganidipine is a Ca2+ antagonist. indicated for acute cardioconversion of and of a recent onset to sinus rhythm.

Purity: 99.84% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg, 250 mg 10 mg, 50 mg, 100 mg

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Ionomycin (SQ23377) Cat. No.: HY-13434 (PN 200-110) Cat. No.: HY-B0233

Bioactivity: Ionomycin (SQ23377) is a Calcium ionophore and an Bioactivity: Isradipine(Dynacirc) is a calcium channel blocker with an IC50 produced by Streptomyces conglobatus ATCC 31005. of 34±8 μM. Target: Calcium Channel Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack[1]. Isradipine… Purity: 98.0% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: Launched Size: 14.1 mM*500 μL in Ethanol , Size: 10mM x 1mL in DMSO, 14.1 mM*100 μL in Ethanol, 10 mg, 50 mg, 100 mg

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) Cat. No.: HY-N0215 Cat. No.: HY-B0347

Bioactivity: L-Phenylalanine is an antagonist at α2δ calcium channels with Bioactivity: Lacidipine (Lacipil, Motens) is a L-type calcium channel a Ki of 980 nM. blocker. Target: Calcium Channel Lacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and… Purity: 98.06% Purity: 99.78% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 g 10 mg, 50 mg, 100 mg, 200 mg

Lemildipine (NB-818; NPK-1886) Cat. No.: HY-19663 Cat. No.: HY-B0612

Bioactivity: Lemildipine is a new dihydropyridine calcium entry blocker. Bioactivity: Lercanidipine is a calcium channel blocker of the dihydropyridine class.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10 mg, 50 mg, 100 mg

Lercanidipine hydrochloride besylate Cat. No.: HY-B0612A ((S)-Amlodipine besylate; Levoamlodipine besylate) Cat. No.: HY-14744A

Bioactivity: Lercanidipine hydrochloride is a calcium channel blocker of Bioactivity: Levamlodipine besylate ((S)-Amlodipine besylate) is a powerful the dihydropyridine class. dihydropyridine calcium channel blocker, possessing properties and used in the treatment of hypertension and angina [1].

Purity: 98.50% Purity: 99.91% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 10 mg, 50 mg

Lomerizine dihydrochloride (KB-2796) Cat. No.: HY-B0768A Cat. No.: HY-B0419

Bioactivity: dihydrochloride is an antagonist of L- and T-type Bioactivity: Manidipine is a calcium channel blocker that is used voltagegated calcium channels. clinically as an antihypertensive.

Purity: 99.97% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 200 mg 50 mg

8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Manidipine dihydrochloride McN5691 (CV-4093) Cat. No.: HY-17403 (RWJ26240) Cat. No.: HY-U00218

Bioactivity: Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a Bioactivity: McN5691 is a voltage-sensitive calcium channel blocker. calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.

Purity: 99.18% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 50 mg, 100 mg

Mibefradil dihydrochloride (Ro 40-5967) Cat. No.: HY-15553 (Ro 40-5967 (dihydrochloride)) Cat. No.: HY-15553A

Bioactivity: Mibefradil is a calcium channel blocker with moderate Bioactivity: Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a 2+ calcium channel blocker with moderate selectivity for T-type selectivity for T-type Ca channels displaying IC50s of 2.7 Ca 2+ channels displaying IC s of 2.7 μM and 18.6 μM for μM and 18.6 μM for T-type and L-type currents, respectively. 50 T-type and L-type currents, respectively. Purity: >98% Purity: 99.63% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Mirogabalin besylate (DS5565) Cat. No.: HY-12650 (DS 5565 besylate) Cat. No.: HY-108006

Bioactivity: Mirogabalin (DS-5565) is a novel, preferentially selective Bioactivity: Mirogabalin besylate is a selective and orally available α2δ-1 ligand characterized by high potency and selectivity to ligand for the α2δ subunit of voltage-gated calcium channels,

the α2δ-1 subunit of voltage-sensitive calcium channel with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human complexes in the CNS. α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.

Purity: 99.31% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

ML218 MRS1845 Cat. No.: HY-103309 Cat. No.: HY-103310

Bioactivity: ML218 is a selective T-type calcium channel inhibitor with Bioactivity: MRS1845 is a Ca2+ channel blocker with relative specificity IC s of 270 and 310 nM for Cav3.3 and Cav3.2 in 50 for store-operated calcium entry (SOCE) channels [1]. electrophysiology assay, respectively.

Purity: 99.49% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size:

Myomodulin N-type calcium channel blocker-1 Cat. No.: HY-P0268 Cat. No.: HY-100310

Bioactivity: Myomodulin is a neuropeptide present in molluscs, insects, and Bioactivity: N-type calcium channel blocker-1 is an orally active analgesic gastropods. agent which shows high affinity to functionally block N-type

calcium channels with an IC50 of 0.7 μM in the IMR32 assay.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

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NecroX-5 Neomycin sulfate Cat. No.: HY-104015 Cat. No.: HY-B0470

Bioactivity: NecroX-5 is a derivative of the NecroX, reduces intracellular Bioactivity: Neomycin sulfate is an aminoglycoside antibiotic used for calcium concentration, and possesses anti-inflammatory and preventing or treating bacterial . anti-cancer activity.

Purity: 99.31% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 10 g, 25 g

Nexopamil racemate Cat. No.: HY-101727 (YC-93) Cat. No.: HY-12515

Bioactivity: Nexopamil racemate is the racemate of Nexopamil. Nexopamil is Bioactivity: Nicardipine(YC-93) is a calcium channel blocker that has been 2+ widely used to control blood pressure in severe hypertension a combined Ca / 5-HT2 antagonist on thrombus formation in following events such as ischemic stroke, traumatic brain vivo and on aggregation in vitro. injury, and intracerebral hemorrhage.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 g, 5 g

Nicardipine Hydrochloride Nifedipine (YC-93 Hydrochloride) Cat. No.: HY-12515A (BAY-a-1040) Cat. No.: HY-B0284

Bioactivity: Nicardipine Hydrochloride (YC-93 Hydrochloride) is a calcium Bioactivity: Nifedipine (BAY-a-1040) is a potent calcium channel blocker channel blocker that has been widely used to control blood and drug of choice for cardiac insufficiencies. pressure in severe hypertension following events such as ischemic stroke, , and intracerebral hemorrhage. Purity: 99.85% Purity: 97.64% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g, 10 g

Nifedipine D6 (BAY-a-1040 D6) Cat. No.: HY-B0284S (FK235; FR34235) Cat. No.: HY-14284

Bioactivity: Nifedipine D6 (BAY-a-1040 D6) is deuterium labeled nifedipine, Bioactivity: Nilvadipine is a potent calcium channel antagonist, and the and nifedipine is a potent calcium channel blocker. IC50 value is around 0.1 nM.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 500 mg

Nimodipine (BAY-e 9736) Cat. No.: HY-B0265 (BAY-k 5552) Cat. No.: HY-17402

Bioactivity: (Nimotop) is a dihydropyridine derivative and an Bioactivity: Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker analogue of the calcium channel blocker nifedipine, with belonging to the dihydropyridines class, specific for L-type antihypertensive activity.Nimodipine decreases intracellular Cav1.2 with IC50 of 10 nM. IC50 value: 10 nM Target: L-type free Ca2+,Beclin-1 and autophagy. Target: Calcium Channel Cav1.2 Nisoldipine is a potent blocker of L-type calcium Nimodipine is main use is in the prevention of cerebral… channels. Nisoldipine binds directly to inactive calcium… Purity: 99.87% Purity: 98.22% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg, 1 g 100 mg, 500 mg

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Nitrendipine NNC 55-0396 (BAY-E-5009) Cat. No.: HY-B0424 (NNC 55-0396 dihydrochloride) Cat. No.: HY-50722

Bioactivity: is a calcium channel blocker with marked Bioactivity: NNC 55-0396, Mibefradil derivative, is a highly selective vasodilator action. Target: Calcium Channel Nitrendipine is a T-type calcium channel blocker; displays IC50 values of 6.8 dihydropyridine calcium channel blocker. It is used in the and > 100 μM for inhibition of Cav3.1 T-type channels and treatment of primary hypertension to decrease blood pressure. HVA currents respectively in INS-1 cells. IC50 value: 6.8 nM Nitrendipine blocked Ca2+ currents very potently, with… Target: Cav3.1 T-type channel NNC 55-0396 can be an essential… Purity: 99.29% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg, 1 g 1 mg, 5 mg

Norverapamil hydrochloride NP118809 ((±)- hydrochloride; D591 hydrochlorid) Cat. No.: HY-100750 (39-1B4) Cat. No.: HY-14462

Bioactivity: Norverapamil hydrochloride is a calcium channel blocker it is Bioactivity: NP118809 is a potent N-type calcium channel blocker, with an the main active metabolite of . In vitro: IC50 of 0.11 μM; also less potently inhibits L-type calcium Norverapamil is similarly effective as verapamil at inhibiting channel with an IC of 12.2 μM. isoniazid and tolerance and killing of 50 intracellular M. tuberculosis in the absence of other .… Purity: 99.46% Purity: 98.62% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg 100 mg, 200 mg, 500 mg

NS-638 Palonidipine Cat. No.: HY-101428 Cat. No.: HY-108997

Bioactivity: NS-638 is a small nonpeptide molecule with Ca2+-channel Bioactivity: Palonidipine is a calcium antagonist which is potential for [1] [2] blocking properties. K +-stimulated intracellular Ca the therapy of angina-pectoris and hypertension 2+ [3]. -elevation is blocked with an IC50 value of 3.4 μM.

Purity: 98.04% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg, 250 mg 5 mg, 10 mg, 50 mg, 100 mg

PD0176078 PD173212 Cat. No.: HY-U00236 Cat. No.: HY-103318

Bioactivity: PD0176078 is a newly found N-type Calcium channel blocker. Bioactivity: PD173212 is a selective N-type voltage sensitive calcium

channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.

Purity: >98% Purity: 95.65% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg

Penfluridol (R-16341) Cat. No.: HY-B1077 Cat. No.: HY-111613

Bioactivity: Penfluridol is a highly potent, first generation Bioactivity: Pinaverium bromide is an L-type calcium channel blocker with diphenylbutylpiperidine antipsychotic. selectivity for the , effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients [1]. Purity: 99.84% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 50 mg

www.MedChemExpress.com 11

Ranolazine dihydrochloride (CVT 303; RS 43285-003) Cat. No.: HY-B0280 (CVT 303 (dihydrochloride); RS 43285) Cat. No.: HY-17401

Bioactivity: Ranolazine is an antianginal . Bioactivity: Ranolazine dihydrochloride (RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting or blood pressure (BP). IC50 value: Target: sodium-dependent calcium… Purity: 98.38% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 100 mg, 200 mg, 500 mg 100 mg, 200 mg, 500 mg, 1 g, 5 g

Semotiadil recemate fumarate Sipatrigine Cat. No.: HY-U00026 (619C89; BW 619C89) Cat. No.: HY-108335

Bioactivity: Semotiadil recemate fumarate is the recemate of Semotiadil Bioactivity: Sipatrigine, a neuroprotective agent, is a glutamate release fumarate. Semotiadil fumarate is a novel vasoselective Ca2+ inhibitor, voltage-dependent and calcium channel antagonist. channel inhibitor, penetrating the central . Has potential to treat focal cerebral and stroke [1]

Purity: >98% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg

SM-6586 SQ-31765 Cat. No.: HY-19062 (SQ31765; SQ 31765) Cat. No.: HY-101740

Bioactivity: SM-6586 is a calcium channel antagonist and inhibitor of Na Bioactivity: SQ-31765 is a benzazepine calcium channel blocker. +/H + and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg

TDN345 Teludipine hydrochloride Cat. No.: HY-101669 (GR53992B; GX1296B ) Cat. No.: HY-101621

Bioactivity: TDN345 is a Ca2+ antagonist, used for the treatment of Bioactivity: Teludipine is a lipophilic calcium channel blocker. vascular and senile including Alzheimer's disease.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg

Tetracaine hydrochloride (Amethocaine hydrochloride) Cat. No.: HY-B0473 (NSC-77037d-Tetrandrine) Cat. No.: HY-13764

Bioactivity: HCl is a potent local anaesthetic and a channel Bioactivity: Tetrandrine (NSC-77037) is a bis-benzyl-isoquinoline alkaloid, function allosteric inhibitor. which inhibits voltage-gated Ca2+ current (ICa) and Ca 2+-activated K+ current.

Purity: 99.97% Purity: 99.90% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 100 mg, 250 mg

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Thapsigargin Tiapamil hydrochloride (Thapsigargin (TG)) Cat. No.: HY-13433 (Ro 11-1781) Cat. No.: HY-101674

Bioactivity: Thapsigargin is an inhibitor of microsomal Ca2+-ATPase. Bioactivity: Tiapamil hydrochloride is a calcium channel blocker.

Purity: 99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg

Trimethadione TTA-Q6 (3,5,5,-Trimethyloxazolidine-2,4-dione) Cat. No.: HY-A0092 Cat. No.: HY-10388

Bioactivity: is an anticonvulsant; commonly Bioactivity: TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in used to treat epileptic conditions. the neurological disease.

Purity: 98.0% Purity: 99.94% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 5 mg, 10 mg, 25 mg, 50 mg

UK51656 Verapamil hydrochloride Cat. No.: HY-101707 ((±)-Verapamil hydrochlorid) Cat. No.: HY-A0064

Bioactivity: UK51656 is a calcium antagonist with IC50 of 4 nM. Bioactivity: Verapamil hydrochloride is a calcium channel antagonist.

Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

YS-201 Cat. No.: HY-U00137 (AD 810; CI 912) Cat. No.: HY-B0124

Bioactivity: YS-201 is a dihydropyridine-type calcium channel antagonist Bioactivity: Zonisamide is a 1,2 benzisoxazole derivative and the first previously in clinical trials for the treatment of angina agent of this chemical class to be developed as an pectoris and hypertension. antiepileptic drug.

Purity: 99.0% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 200 mg, 500 mg

Zonisamide sodium ZSET1446 (AD 810 sodium; CI 912 sodium) Cat. No.: HY-B0124A (ST-101) Cat. No.: HY-11013

Bioactivity: Zonisamide sodium is a 1,2 benzisoxazole derivative and the Bioactivity: ZSET1446 is a novel cognitive enhancer that significantly first agent of this chemical class to be developed as an improves learning deficits in various types of Alzheimer antiepileptic drug. disease (AD) models.

Purity: >98% Purity: 98.03% Clinical Data: Launched Clinical Data: Phase 2 Size: 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

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β-Amino Acid Imagabalin Hydrochloride (PD-0332334) Cat. No.: HY-U00250

Bioactivity: β- Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel.

Purity: >98% Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg

14 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]