Calcium Channel Ca2+ channels;Ca channels Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca 2+ into cells despite a 70-fold higher extracellular concentration of Na +. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat. www.MedChemExpress.com 1 Calcium Channel Inhibitors & Modulators (+)-Kavain ABT-639 Cat. No.: HY-B1671 Cat. No.: HY-19721 Bioactivity: (+)-Kavain, a main kavalactone extracted from Piper Bioactivity: ABT-639 is a novel, peripherally acting, selective T-type methysticum, has anticonvulsive properties, attenuating Ca2+ channel blocker. vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca 2+ channels [1]. (+)-Kav… Purity: 99.98% Purity: 99.15% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg ABT-639 hydrochloride Acetylcholine chloride Cat. No.: HY-101616 (Ach; ACh chloride) Cat. No.: HY-B0282 Bioactivity: ABT-639 hydrochloride is a novel, peripherally acting, Bioactivity: Acetylcholine (chloride) is a common neurotransmitter found selective T-type Ca2+ channel blocker. in the central and peripheral nerve system. Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g ACT-709478 AE0047 Hydrochloride Cat. No.: HY-112723 Cat. No.: HY-U00284 Bioactivity: ACT-709478 is a potent, selective, orally active, and brain Bioactivity: AE0047 Hydrochloride is a calcium blocker, used in the penetrating T-type calcium channel blocker. ACT-709478 is used research of hypertensive disease. in the research of generalized epilepsies [1]. Purity: 99.68% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg Amlodipine Amlodipine besylate Cat. No.: HY-B0317 (Amlodipine benzenesulfonate) Cat. No.: HY-B0317B Bioactivity: Amlodipine is a long-acting calcium channel blocker. Bioactivity: Amlodipine besylate is a long-acting calcium channel blocker. Purity: 99.57% Purity: 98.21% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g Amlodipine maleate Anipamil Cat. No.: HY-B0317A Cat. No.: HY-U00044 Bioactivity: Amlodipine maleate is a long-acting calcium channel blocker. Bioactivity: Anipamil is a long-acting calcium channel blocker, used for the treatment of cardiovascular disease. Purity: 99.87% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 1 g, 5 g 2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Aranidipine Azelnidipine (MPC1304) Cat. No.: HY-U00212 (CS 905) Cat. No.: HY-B0023 Bioactivity: Aranidipine (MPC1304) is a Ca2+ channel antagonist with Bioactivity: Azelnidipine(CS 905; Calblock) is a novel dihydropyridine potent and long-lasting antihypertensive effects. derivative, a L-type calcium channel blocker, and an antihypertensive. Purity: >98% Purity: 99.35% Clinical Data: Launched Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg Azelnidipine D7 Bay-K-8644 ((R)-(+)-) (CS-905 D7) Cat. No.: HY-B0023S ((R)-(+)-Bay-K-8644; R-4407; NI-105; (+)-BAY-K-8644) Cat. No.: HY-15125 Bioactivity: Azelnidipine D7 is deuterium labeled Azelnidipine, which is a Bioactivity: Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. L-type calcium channel blocker. 2+ Bay-K-8644 (R)-(+)- inhibits Ba currents ( IBa) ( IC50=975 nM). Purity: >98% Purity: 98.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg Bay-K-8644 ((S)-(-)-) Benidipine hydrochloride ((S)-(-)-Bay-K-8644; (-)-BAY-R-5417; (-)-BAY-K-8644) Cat. No.: HY-15124 (KW-3049) Cat. No.: HY-B1448 Bioactivity: Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bioactivity: Benidipine hydrochloride is a dihydropyridine calcium channel blocker for the treatment of high blood pressure Bay-K-8644 (S)-(-)- activates Ba 2+ currents ( I ) ( Ba (hypertension). EC50=32 nM). Purity: 98.34% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg Bepridil hydrochloride Ca2+ channel agonist 1 (CERM 1978) Cat. No.: HY-103315 Cat. No.: HY-41076 Bioactivity: Bepridil hydrochloride (CERM 1978) is a calcium channel Bioactivity: Ca 2+ channel agonist 1 is an agonist of N-type Ca2+ channel blocker, with antianginal activity. and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. Purity: 99.76% Purity: 99.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg Calcium channel inhibitor 1 Calcium channel-modulator-1 Cat. No.: HY-101096 Cat. No.: HY-U00135 Bioactivity: Calcium channel inhibitor 1 (compound 33) is a potent and Bioactivity: Calcium channel-modulator-1 is a calcium channel modulator; selective inhibitor of the T-type calcium channel. blocks aortic contraction with an IC50 of 0.8 μM. Purity: 99.82% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg www.MedChemExpress.com 3 Carboxyamidotriazole Cav 2.2 blocker 1 (L 651582; CAI) Cat. No.: HY-16126 Cat. No.: HY-119373 Bioactivity: Carboxyamidotriazole (L 651582; CAI) is a blocker of Bioactivity: Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel [1] non-voltage dependent calcium channel . (Cav 2.2) blocker for the treatment of pain, with an IC50 of Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic 1 nM [1]. anti-tumor drug, which also shows anti-inflammatory activ… Purity: 99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 100 mg, 500 mg, 250 mg CDN1163 Cilnidipine Cat. No.: HY-101455 (FRC-8653) Cat. No.: HY-17404 Bioactivity: CDN1163 is a sarco/endoplasmic reticulum Ca2+-ATPase ( Bioactivity: Cilnidipine(FRC8653) is a dual L- and N-type calcium channel SERCA) activator. blocker and displays antihypertensive, sympatholytic and neuroprotective activity. Purity: 99.12% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg Cinnarizine Clevidipine Cat. No.: HY-B1090 Cat. No.: HY-17436 Bioactivity: Cinnarizine is an antihistamine and a calcium channel blocker, Bioactivity: Clevidipine is a short-acting dihydropyridine calcium channel promote cerebral blood flow, used to treat cerebral apoplexy, antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development post-trauma cerebral symptoms, and cerebral arteriosclerosis. for treatment of perioperative hypertension. IC50 Value: 7.1 nM at V(H) = -40 mV [1] Target: calcium channel in vitro: Both clevidipine and nitroglycerin completely reversed… Purity: 98.0% Purity: 99.74% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 50 mg, 100 mg CP-060 Cromolyn sodium Cat. No.: HY-U00354 (Disodium Cromoglycate; FPL-670) Cat. No.: HY-B0320A Bioactivity: CP-​060 is a potent Ca2+ antagonist, inhibits Ca 2+ Bioactivity: Cromolyn (sodium) is an antiallergic drug. overload and possesses antioxidant and cardioprotective activities. Purity: >98% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in Water, 1 g, 5 g CV-159 Dantrolene sodium Cat. No.: HY-19025 (F 440) Cat. No.: HY-14657 Bioactivity: CV-159 is a unique dihydropyridine Ca2+ antagonist with an Bioactivity: Dantrolene sodium is a inhibitor of calcium channel proteins, anti-calmodulin (CaM) action, and has antiinflammatory inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene activities. sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 100 mg, 500 mg 4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Dantrolene sodium hemiheptahydrate Darodipine (Dantrolene sodium hydrate) Cat. No.: HY-12542A (PY 108-068; PY-108068) Cat. No.: HY-U00086 Bioactivity: Dantrolene sodium hemiheptahydrate is a skeletal muscle Bioactivity: Darodipine (PY 108-068, PY-108068) is a potent calcium relaxant which acts by blocking muscle contraction beyond the channel antagonist. neuromuscular junction. Dantrolene sodium hemiheptahydrate is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 100 mg, 200 mg, 500 mg Dehydronitrosonisoldipine DHBP dibromide Cat. No.: HY-Z0816 (Diheptylviologen dibromide) Cat. No.: HY-101237 Bioactivity: Dehydronitrosonisoldipine is a calcium channel antagonist. Bioactivity: DHBP dibromide is an inhibitor for calcium release and a muscle relaxant. Purity: 98.79% Purity: 99.56% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg 100 mg Diltiazem hydrochloride Dopropidil (CRD-401) Cat.