A Longterm Comparison of the Influence of Organic And
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Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity
toxins Article Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity Massimo Picardo 1 , Oscar Núñez 2,3 and Marinella Farré 1,* 1 Department of Environmental Chemistry, IDAEA-CSIC, 08034 Barcelona, Spain; [email protected] 2 Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, 08034 Barcelona, Spain; [email protected] 3 Serra Húnter Professor, Generalitat de Catalunya, 08034 Barcelona, Spain * Correspondence: [email protected] Received: 5 October 2020; Accepted: 26 November 2020; Published: 28 November 2020 Abstract: This study presents the application of a suspect screening approach to screen a wide range of natural toxins, including mycotoxins, bacterial toxins, and plant toxins, in surface waters. The method is based on a generic solid-phase extraction procedure, using three sorbent phases in two cartridges that are connected in series, hence covering a wide range of polarities, followed by liquid chromatography coupled to high-resolution mass spectrometry. The acquisition was performed in the full-scan and data-dependent modes while working under positive and negative ionisation conditions. This method was applied in order to assess the natural toxins in the Ter River water reservoirs, which are used to produce drinking water for Barcelona city (Spain). The study was carried out during a period of seven months, covering the expected prior, during, and post-peak blooming periods of the natural toxins. Fifty-three (53) compounds were tentatively identified, and nine of these were confirmed and quantified. Phytotoxins were identified as the most frequent group of natural toxins in the water, particularly the alkaloids group. -
Behavior of Α-Tomatine and Tomatidine Against Several Genera of Trypanosomatids from Insects and Plants and Trypanosoma Cruzi
Acta Scientiarum http://periodicos.uem.br/ojs/acta ISSN on-line: 1807-863X Doi: 10.4025/actascibiolsci.v40i1.41853 BIOTECHNOLOGY Behavior of α-tomatine and tomatidine against several genera of trypanosomatids from insects and plants and Trypanosoma cruzi Adriane Feijó Evangelista1, Erica Akemi Kavati2, Jose Vitor Jankevicius3 and Rafael Andrade Menolli4* 1Centro de Pesquisa em Oncologia Molecular, Hospital de Câncer de Barretos, Barretos, São Paulo, Brazil. 2Laboratório de Genética, Instituto Butantan, São Paulo, São Paulo, Brazil. 3Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brazil. 4Centro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Rua Universitária, 2069, 85819-110, Cascavel, Paraná, Brazil. *Author for correspondence. E-mail: [email protected] ABSTRACT. Glycoalkaloids are important secondary metabolites accumulated by plants as protection against pathogens. One of them, α-tomatine, is found in high concentrations in green tomato fruits, while in the ripe fruits, its aglycone form, tomatidine, does not present a protective effect, and it is usual to find parasites of tomatoes like Phytomonas serpens in these ripe fruits. To investigate the sensitivity of trypanosomatids to the action of α-tomatine, we used logarithmic growth phase culture of 20 trypanosomatids from insects and plants and Trypanosoma cruzi. The lethal dose 50% (LD50) was determined by mixing 107 cells of the different isolates with α-tomatine at concentrations ranging from 10-3 to 10-8 M for 30 min at room temperature. The same tests performed with the tomatidine as a control showed no detectable toxicity against the same trypanosomatid cultures. The tests involved determination of the percentage (%) survival of the protozoan cultures in a Neubauer chamber using optical microscopy. -
Alpha-Tomatine Content in Tomato and Tomato Products Determined By
J. Agric. Food Chem. 1995, 43, 1507-151 1 1507 a-Tomatine Content in Tomato and Tomato Products Determined by HPLC with Pulsed Amperometric Detection Mendel Friedman* and Carol E. Levin Food Safety and Health Research Unit, Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, 800 Buchanan Street, Albany, California 94710 Tomato plants (Lycopersicon esculentum) synthesize the glycoalkaloid a-tomatine, possibly as a defense against insects and other pests. As part of an effort to improve the safety of plant foods, the usefulness of a new HPLC pulsed amperometric detection (PAD) method for the direct analysis of a-tomatine in different parts of the tomato plant; in store-bought and field-grown, including transgenic, tomatoes; in a variety of commercial and home-processed tomato products; and in eggplant and tomatillos was evaluated. The method was found to be useful for analysis of a variety of products including high-tomatine calyxes, flowers, leaves, roots, and stems of the tomato plant (14-130 mg/100 g of fresh weight), low-tomatine red tomatoes (0.03-0.08 mg/100 g), intermediate- tomatine tomatoes (0.1-0.8 mg/100 g), and high-tomatine fresh and processed green, including pickled and fried, tomatoes (0.9-55 mg/100 g). No experimental difficulties were encountered with extraction and analysis of tomatine in complex foods such as tomato juice, ketchup, salsa, sauce, and sun-dried tomatoes. Microwaving and frying did not significantly affect tomatine levels of tomato foods. The tomatine content of fresh market and transgenic delayed-ripening varieties was not different from the range ordinarily seen in tomato. -
Tomatine Adjuvantation of Protective Immunity to a Major Pre-Erythrocytic Vaccine Candidate of Malaria Is Mediated Via CD8+ T Cell Release of IFN-Γ
Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2010, Article ID 834326, 7 pages doi:10.1155/2010/834326 Research Article Tomatine Adjuvantation of Protective Immunity to a Major Pre-erythrocytic Vaccine Candidate of Malaria is Mediated via CD8+ T Cell Release of IFN-γ Karen G. Heal1, 2 and Andrew W. Taylor-Robinson1 1 Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK 2 Department of Biology, University of York, York YO10 5YW, UK Correspondence should be addressed to Andrew W. Taylor-Robinson, [email protected] Received 1 August 2009; Revised 26 October 2009; Accepted 8 January 2010 Academic Editor: Abhay R. Satoskar Copyright © 2010 K. G. Heal and A. W. Taylor-Robinson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The glycoalkaloid tomatine, derived from the wild tomato, can act as a powerful adjuvant to elicit an antigen-specific cell-mediated immune response to the circumsporozoite (CS) protein, a major pre-erythrocytic stage malaria vaccine candidate antigen. Using a defined MHC-class-I-restricted CS epitope in a Plasmodium berghei rodent model, antigen-specific cytotoxic T lymphocyte activity and IFN-γ secretion ex vivo were both significantly enhanced compared to responses detected from similarly stimulated splenocytes from naive and tomatine-saline-immunized mice. Further, through lymphocyte depletion it is demonstrated that antigen-specific IFN-γ is produced exclusively by the CD8+ T cell subset. -
Veterinary Toxicology
GINTARAS DAUNORAS VETERINARY TOXICOLOGY Lecture notes and classes works Study kit for LUHS Veterinary Faculty Foreign Students LSMU LEIDYBOS NAMAI, KAUNAS 2012 Lietuvos sveikatos moksl ų universitetas Veterinarijos akademija Neužkre čiam ųjų lig ų katedra Gintaras Daunoras VETERINARIN Ė TOKSIKOLOGIJA Paskait ų konspektai ir praktikos darb ų aprašai Mokomoji knyga LSMU Veterinarijos fakulteto užsienio studentams LSMU LEIDYBOS NAMAI, KAUNAS 2012 UDK Dau Apsvarstyta: LSMU VA Veterinarijos fakulteto Neužkre čiam ųjų lig ų katedros pos ėdyje, 2012 m. rugs ėjo 20 d., protokolo Nr. 01 LSMU VA Veterinarijos fakulteto tarybos pos ėdyje, 2012 m. rugs ėjo 28 d., protokolo Nr. 08 Recenzavo: doc. dr. Alius Pockevi čius LSMU VA Užkre čiam ųjų lig ų katedra dr. Aidas Grigonis LSMU VA Neužkre čiam ųjų lig ų katedra CONTENTS Introduction ……………………………………………………………………………………… 7 SECTION I. Lecture notes ………………………………………………………………………. 8 1. GENERAL VETERINARY TOXICOLOGY ……….……………………………………….. 8 1.1. Veterinary toxicology aims and tasks ……………………………………………………... 8 1.2. EC and Lithuanian legal documents for hazardous substances and pollution ……………. 11 1.3. Classification of poisons ……………………………………………………………………. 12 1.4. Chemicals classification and labelling ……………………………………………………… 14 2. Toxicokinetics ………………………………………………………………………...………. 15 2.2. Migration of substances through biological membranes …………………………………… 15 2.3. ADME notion ………………………………………………………………………………. 15 2.4. Possibilities of poisons entering into an animal body and methods of absorption ……… 16 2.5. Poison distribution -
Bioactive Compounds of Tomatoes As Health Promoters
48 Natural Bioactive Compounds from Fruits and Vegetables, 2016, Ed. 2, 48-91 CHAPTER 3 Bioactive Compounds of Tomatoes as Health Promoters José Pinela1,2, M. Beatriz P. P Oliveira2, Isabel C.F.R. Ferreira1,* 1 Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, Ap. 1172, 5301-855 Bragança, Portugal 2 REQUIMTE/LAQV, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal Abstract: Tomato (Lycopersicon esculentum Mill.) is one of the most consumed vegetables in the world and probably the most preferred garden crop. It is a key component of the Mediterranean diet, commonly associated with a reduced risk of chronic degenerative diseases. Currently there are a large number of tomato cultivars with different morphological and sensorial characteristics and tomato-based products, being major sources of nourishment for the world’s population. Its consumption brings health benefits, linked with its high levels of bioactive ingredients. The main compounds are carotenoids such as β-carotene, a precursor of vitamin A, and mostly lycopene, which is responsible for the red colour, vitamins in particular ascorbic acid and tocopherols, phenolic compounds including hydroxycinnamic acid derivatives and flavonoids, and lectins. The content of these compounds is variety dependent. Besides, unlike unripe tomatoes, which contain a high content of tomatine (glycoalkaloid) but no lycopene, ripe red tomatoes contain high amounts of lycopene and a lower quantity of glycoalkaloids. Current studies demonstrate the several benefits of these bioactive compounds, either isolated or in combined extracts, namely anticarcinogenic, cardioprotective and hepatoprotective effects among other health benefits, mainly due to its antioxidant and anti-inflammatory properties. -
Fall TNP Herbals.Pptx
8/18/14 Introduc?on to Objecves Herbal Medicine ● Discuss history and role of psychedelic herbs Part II: Psychedelics, in medicine and illness. Legal Highs, and ● List herbs used as emerging legal and illicit Herbal Poisons drugs of abuse. ● Associate main plant and fungal families with Jason Schoneman RN, MS, AGCNS-BC representave poisonous compounds. The University of Texas at Aus?n ● Discuss clinical management of main toxic Schultes et al., 1992 compounds. Psychedelics Sacraments: spiritual tools or sacred medicine by non-Western cultures vs. Dangerous drugs of abuse vs. Research and clinical tools for mental and physical http://waynesword.palomar.edu/ww0703.htm disorders History History ● Shamanic divinaon ○ S;mulus for spirituality/religion http://orderofthesacredspiral.blogspot.com/2012/06/t- mckenna-on-psilocybin.html http://www.cosmicelk.net/Chukchidirections.htm 1 8/18/14 History History http://www.10zenmonkeys.com/2007/01/10/hallucinogenic- weapons-the-other-chemical-warfare/ http://rebloggy.com/post/love-music-hippie-psychedelic- woodstock http://fineartamerica.com/featured/misterio-profundo-pablo- amaringo.html History ● Psychotherapy ○ 20th century: un;l 1971 ● Recreaonal ○ S;mulus of U.S. cultural revolu;on http://qsciences.digi-info-broker.com http://www.uspharmacist.com/content/d/feature/c/38031/ http://en.wikipedia.org/nervous_system 2 8/18/14 Main Groups Main Groups Tryptamines LSD, Psilocybin, DMT, Ibogaine Other Ayahuasca, Fly agaric Phenethylamines MDMA, Mescaline, Myristicin Pseudo-hallucinogen Cannabis Dissociative -
Tomato Juice Saponin, Esculeoside B Ameliorates Mice Experimental Dermatitis
Functional Foods in Health and Disease 2018; 8(4): 228-241 Page 228 of 241 Research Article Open Access Tomato juice saponin, esculeoside B ameliorates mice experimental dermatitis *Jian-Rong Zhou, Jun Urata, Takuya Shiraishi, Chiaki Tanaka, Toshihiro Nohara, Kazumi Yokomizo Department of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan Corresponding author: Jian-Rong Zhou, PhD, Department of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishiku, Kumamoto 860-0082, Japan Submission Date: February 16th, 2018, Acceptance Date: April 27th, 2018, Publication Date: April 30th, 2018 Citation: Zhou J., Urata J., Shiraishi T., Tanaka C., Nohara T., Yokomizo K., Tomato juice saponin, esculeoside B ameliorates mice experimental dermatitis. Functional Foods in Health and Disease 2018; 8(4): 228-241 ABSTRACT Background: Allergic diseases like atopic dermatitis have recently increased. A naturally occurring glycoside, Esculeoside B, has been identified as a major component in tomato juice from the can. Accordingly, the present study investigated the effects of esculeoside B on experimental dermatitis mice. Results: Oral treatment with 10 mg/kg of esculeoside B on the experimental dermatitis mice for 4 weeks significantly decreased the skin clinical score of 2.0 compared to the control score of 5.0. Furthermore, the scratch frequency of mice treated with esculeoside B was lower compared to the Functional Foods in Health and Disease 2018; 8(4): 228-241 Page 229 of 241 control group. Overall, the administration of esculeoside B significantly inhibited T lymphocyte proliferation and demonstrated a tendency to decrease in IL-4 production. -
Plasma LDL Cholesterol Lowering by Plant Phytosterols in a Hamster Model
Trends in Food Science & Technology 15 (2004) 528–531 Viewpoint Plasma LDL people annually (Chronic Diseases and Their Risk Factors, cholesterol lowering 1999). It is the major cause of death in the US Risk factors include increasing age, gender, heredity, overweight, low physical activity, tobacco smoke, high blood pressure, and by plant phytosterols diabetes. High serum cholesterol (>240 mg/dl) and high concentrations of low-density lipoprotein cholesterol in a hamster model (LDL-C, >160 mg/dl) are also risk factors for cardiovas- cular disease (AHA. American Heart Association, 2000). Risk factors such as overweight, physical inactivity, Wallace H. Yokoyama & smoking, diabetes, and serum cholesterol can be reduced. USDA, Agricultural Research Service, Western Since the 1950s, it has been known that plant sterol mixtures Regional Research Center, Albany, CA 94710, USA can reduce plasma cholesterol, and recently, the US Food and Drug Administration recognized the effectiveness of these compounds (stanol and sterol esters), by approving health claims for margarines and other foods containing these compounds (Federal Register, 2000). Cardiovascular disease is still the main cause of death in Fig. 1 shows the structures of cholesterol, b-sitosterol the US. High plasma cholesterol, 51.9% of Americans have and cycloartenol ferulate. Phytosterols such as b-sitosterol cholesterol levels of 200 mg/dl or higher and especially or campesterol are examples of cholesterol-lowering sterols low-density lipoprotein (LDL) cholesterol, and high ratios that can be used in margarines. These compounds are of LDL to high-density lipoprotein (HDL) cholesterol are commonly found in oils of plant origin, such as soy, corn, risk factors for cardiovascular disease. -
Antimicrobial Activities of Saponin-Rich Guar Meal Extract
ANTIMICROBIAL ACTIVITIES OF SAPONIN-RICH GUAR MEAL EXTRACT A Dissertation by SHERIF MOHAMED HASSAN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY May 2008 Major Subject: Poultry Science ANTIMICROBIAL ACTIVITIES OF SAPONIN-RICH GUAR MEAL EXTRACT A Dissertation by SHERIF MOHAMED HASSAN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved by: Chair of Committee, Aubrey L. Cartwright Committee Members, Christopher A. Bailey James A. Byrd Michael E. Hume Head of Department, John B. Carey May 2008 Major Subject: Poultry Science iii ABSTRACT Antimicrobial Activities of Saponin-Rich Guar Meal Extract. (May 2008) Sherif Mohamed Hassan, B.S.; M.S., Suez Canal University Chair of Advisory Committee: Dr. Aubrey Lee Cartwright Three saponin-rich extracts (20, 60, 100% methanol), four 100% methanol sub- fractions and seven independently acquired fractions (A-G) from guar meal, Cyamopsis tetragonoloba L. (syn. C. psoraloides), were evaluated for antimicrobial and hemolytic activities. These activities were compared against quillaja bark (Quillaja saponaria), yucca (Yucca schidigera), and soybean (Glycine max) saponins in 96-well plates using eight concentrations (0.01 to 1.0 and 0.1 to 12.5 mg extract/mL). Initial guar meal butanol extract was 4.8 ± 0.6% of the weight of original material dry matter (DM). Butanol extract was purified by preparative reverse-phase C-18 chromatography. Two fractions eluted with 20, and one each with 60, and 100% methanol with average yields of 1.72 ± 0.47, 0.88 ± 0.16, 0.91 ± 0.16 and 1.55 ± 0.15% of DM, respectively. -
Environmental Health Human Health
Environmental Health Human Health Health & Environmental Solutions Network Christopher Vakas – 17 October 2017 Environmental Health Risk Management (EHRM) Health & Environmental Solutions Network Recycled drinking water Health & Environmental Solutions Network Health & Environmental Solutions Network Intrusive noise – how much is to much • Traffic • Rail • Aircraft • Air conditioners • Pool pumps • Compressors • Loud music • Power tools • Concerts Health & Environmental Solutions Network Clandestine drug labs • The drug “cooks” don’t care • Chemicals destroy property • Drugs destroy lives • Are dangerous • Volatile organic compounds • Weapons • Aggressive people Health & Environmental Solutions Network To produce 1 kg of methamphetamine in excess of 30 kg of toxic waste is produced Health & Environmental Solutions Network Food safety – Heat Stable Toxins • Seafood toxins – Saxitoxin and its derivatives • Green Potatoes – Solanine • Staphylococcal & Streptococcal – Enterotoxin • Clostridium Botulinum - Botulinum • FSS 3.2.2 Clause 7 Food Processing • How long is too long for foods that are yet to undergo a pathogen control step? • (2) A food business must, when processing potentially hazardous food that is not undergoing a pathogen control step, ensure that the time the food remains at temperatures that permit the growth of infectious or toxigenic micro-organisms in the food is minimised. Health & Environmental Solutions Network Seafood Toxins • collectively referred to as paralytic shellfish toxins (PSTs), • paralytic shellfish poisoning (PSP), • amnesic shellfish poisoning (ASP), • diarrheic shellfish poisoning (DSP), • ciguatera shellfish poisoning (CFP), • azaspiracid shellfish poisoning (AZP) • Responsible for 750 to 7500 death annually, from up to 0.5 M cased reported • Saxitoxin is one of the most potent neurotoxins • Ciguatoxin CTXs are tasteless, colourless, odourless, heat and acid stable, and stable for at least six months at commercial freezing temperatures. -
Poisonous Plants in New Zealand
THE NEW ZEALAND MEDICAL JOURNAL Journal of the New Zealand Medical Association Poisonous plants in New Zealand: a review of those that are most commonly enquired about to the National Poisons Centre Robin J Slaughter, D Michael G Beasley, Bruce S Lambie, Gerard T Wilkins, Leo J Schep Abstract Introduction New Zealand has a number of plants, both native and introduced, contact with which can lead to poisoning. The New Zealand National Poisons Centre (NZNPC) frequently receives enquiries regarding exposures to poisonous plants. Poisonous plants can cause harm following inadvertent ingestion, via skin contact, eye exposures or inhalation of sawdust or smoked plant matter. Aim The purpose of this article is to determine the 15 most common poisonous plant enquiries to the NZNPC and provide a review of current literature, discussing the symptoms that might arise upon exposure to these poisonous plants and the recommended medical management of such poisonings. Methods Call data from the NZNPC telephone collection databases regarding human plant exposures between 2003 and 2010 were analysed retrospectively. The most common plants causing human poisoning were selected as the basis for this review. An extensive literature review was also performed by systematically searching OVID MEDLINE, ISI Web of Science, Scopus and Google Scholar. Further information was obtained from book chapters, relevant news reports and web material. Results For the years 2003–2010 inclusive, a total of 256,969 enquiries were received by the NZNPC. Of these enquiries, 11,049