Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamide
Pain Medicine 2010; 11: 781–784 Wiley Periodicals, Inc. Case Reports Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamidepme_823 781..784 Rocco Salvatore Calabrò, MD, Giuseppe Gervasi, frequency, erectile dysfunction, and pain after sexual Downloaded from https://academic.oup.com/painmedicine/article/11/5/781/1843389 by guest on 23 September 2021 MD, Silvia Marino, MD, Pasquale Natale Mondo, intercourse). MD, and Placido Bramanti, MD Patients typically present with pain in the labia or penis, IRCCS Centro Neurolesi “Bonino-Pulejo,” Messina, Italy perineum, anorectal region, and scrotum, which is aggra- vated by sitting, relieved by standing, and absent when Reprint requests to: Rocco Salvatore Calabrò, MD, via recumbent or when sitting on a lavatory seat. In the Palermo, Cda Casazza, Messina. Tel: 390903656722; absence of pathognomonic imaging, laboratory, and elec- Fax: 390903656750; E-mail: roccos.calabro@ trophysiology criteria, the diagnosis of PN remains primarily centroneurolesi.it. clinical [1], and it is often delayed. Furthermore, this condi- tion is frequently misdiagnosed and sometimes results in unnecessary surgery. Here in we describe a 40-year-old man presenting with chronic pelvic pain due to pudendal Abstract nerve entrapment, misdiagnosed as chronic prostatitis. Background. Pudendal neuralgia is a cause of After different uneffective pharmacological therapies, chronic, disabling, and often intractable perineal the patient was treated with palmitoylethanolamide (PEA), pain presenting as burning, tearing, sharp shooting, an endogenous lipid with antinociceptive and anti- foreign body sensation, and it is often associated inflammatory properties [2,3] with significant improvement with multiple, perplexing functional symptoms. of his neuralgia. Case Report. We report a case of a 40-year-old man Case Report presenting with chronic pelvic pain due to pudendal nerve entrapment and successfully treated with A 40-year-old healthy man developed since 5 years a palmitoylethanolamide (PEA).
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