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Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamide

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Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamide Pain Medicine 2010; 11: 781–784 Wiley Periodicals, Inc. Case Reports Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamidepme_823 781..784 Rocco Salvatore Calabrò, MD, Giuseppe Gervasi, frequency, erectile dysfunction, and pain after sexual Downloaded from https://academic.oup.com/painmedicine/article/11/5/781/1843389 by guest on 23 September 2021 MD, Silvia Marino, MD, Pasquale Natale Mondo, intercourse). MD, and Placido Bramanti, MD Patients typically present with pain in the labia or penis, IRCCS Centro Neurolesi “Bonino-Pulejo,” Messina, Italy perineum, anorectal region, and scrotum, which is aggra- vated by sitting, relieved by standing, and absent when Reprint requests to: Rocco Salvatore Calabrò, MD, via recumbent or when sitting on a lavatory seat. In the Palermo, Cda Casazza, Messina. Tel: 390903656722; absence of pathognomonic imaging, laboratory, and elec- Fax: 390903656750; E-mail: roccos.calabro@ trophysiology criteria, the diagnosis of PN remains primarily centroneurolesi.it. clinical [1], and it is often delayed. Furthermore, this condi- tion is frequently misdiagnosed and sometimes results in unnecessary surgery. Here in we describe a 40-year-old man presenting with chronic pelvic pain due to pudendal Abstract nerve entrapment, misdiagnosed as chronic prostatitis. Background. Pudendal neuralgia is a cause of After different uneffective pharmacological therapies, chronic, disabling, and often intractable perineal the patient was treated with palmitoylethanolamide (PEA), pain presenting as burning, tearing, sharp shooting, an endogenous lipid with antinociceptive and anti- foreign body sensation, and it is often associated inflammatory properties [2,3] with significant improvement with multiple, perplexing functional symptoms. of his neuralgia. Case Report. We report a case of a 40-year-old man Case Report presenting with chronic pelvic pain due to pudendal nerve entrapment and successfully treated with A 40-year-old healthy man developed since 5 years a palmitoylethanolamide (PEA). progressive predominantly left-sided perineal pain described as burning sensation. Initially, the patient expe- Conclusion. PEA may induce relief of neuropathic rienced the pain only in the sitting position, but pain gradu- pain through an action upon receptors located on ally became continuous and extended to penis. Moreover, the nociceptive pathway as well as a more direct it was often referred as deeper in the anorectal region (as action on mast cells via an ALIA (autocoid local a feeling of “foreign body”) and sometimes in distal injury antagonism) mechanism. urethra. Pain was exacerbated while sitting, relieved while standing, and nearly absent when recumbent or sitting in As recently demonstrated in animal models, the a toilet seat. Furthermore, in some circumstances, pain present case suggests that PEA could be a valuable was associated to painful ejaculation, erectile dysfunction, pharmacological alternative to the most common urge incontinence, and dysuria. The patient also referred drugs (anti-epileptics and antidepressants) used in intolerance to tight clothes and underwear. Over this long the treatment of neuropathic pain. period, he saw many different health care professionals (family practitioners, urologists, neurologists, and psychia- Key Words. PEA; Pudendal Neuralgia; Chronic Pain trists), and he was given different diagnoses (abacterial chronic prostatitis, prostatodynia, idiopathic proctalgia, Introduction coccygodynia, and psychogenic pain). Pudendal neuralgia (PN) is a cause of chronic, disabling, Urinalysis with culture, semen analysis, sexual hormones and often intractable perineal pain and it is mostly due to blood level, pelvic, and transrectal prostatic ultrasounds pudendal nerve entrapment. were normal. As chronic pelvic pain syndrome was supposed, he was treated with several drugs such Neuropathic pain is referred as burning, tearing, sharp as antibiotics (ciprofloxacin, levofloxacine, gentamicin, shooting, and foreign body sensation in the distribution azitromycine, and trimethoprim/sulfamethoxazole), antimi- of the pudendal nerve and it is often associated with cotics (fluconazole), and anti-inflammatories (nimesulid, multiple, perplexing functional symptoms (i.e., urinary corticosteroids) with only transient mild relief. 781 Calabrò et al. At our evaluation, the patient’s physical and neurological Table 1 Nantes criteria, September 23–24, 2006 examinations were unremarkable with the exception of a mild hyperesthesia in the perineal area during the pinprick Diagnostic Criteria for Pudendal Neuralgia by sensory test. Interestingly, digital rectal exploration evi- Pudendal Nerve Entrapment denced unilateral perineal and rectal pain after pressure on the left ischial spine. The personal history (the patient was A. Essential criteria an amateur bicycler and regularly attended a fitness/body- Pain in the territory of the pudendal nerve: from building center) and the neuropathic pain features, also the anus to the penis or clitoris reproduced during rectal exam, led us to the diagnosis of Pain is predominantly experienced while sitting PN probably secondary to nerve compression. Pain was The pain dose not wake the patient at night rated by the patient at 8 on the 0–10 visual analog scale Pain with no objective sensory impairment Downloaded from https://academic.oup.com/painmedicine/article/11/5/781/1843389 by guest on 23 September 2021 (VAS). Magnetic resonance imaging of the pelvic area Pain relieved by diagnostic pudendal nerve block failed to point out organic lesions of the nerve trunk. B. Complementary diagnostic criteria Pudendal somatosensory evoked potentials and bulb- Burning, shooting, stabbing pain, numbness ocavernosus reflex with the electromyography of the Allodynia or hyperpathia pelvic floor musculature showed denervation activity of the Rectal or vaginal foreign body sensation anal sphincter. Thus, the patient was treated with pre- (sympathalgia) gabalin, up to 150 mg/day, prematurely withdrawn Worsening of pain during the day because of significant side effects. As the patient refused Predominantly unilateral pain any other specific pharmacological pain treatment (i.e., Pain triggered by defecation antidepressants and anti-epileptics), PEA, up to 900 mg/ Presence of exquisite tenderness on palpation of day, was introduced with a significant improvement of his the ischial spine neuralgia and associated symptoms. Clinical neurophysiology findings in men or nulliparous women Discussion C. Exclusion criteria The pudendal nerve is a mixed nerve (motory, sensory, Exclusively coccygeal, gluteal, pubic, or and autonomic) composed of three branches: dorsal hypogastric pain nerve of penis/clitoris, perineal nerve, and inferior anal Pruritus nerve, all derived from sacral S2-S4 roots. It supplies the Exclusively paroxysmal pain anal and urethral sphincters and pelvic floor muscles and Imaging abnormalities able to account for the pain provides anal, perineal, and genital sensitivity. Pudendal D. Associated signs not excluding the diagnosis nerve entrapment at different levels (ischial spine, sacros- Buttock pain on sitting pinous, and sacrotuberous ligament, Alcock’s canal) is a Referred sciatic pain cause of disabling, chronic, and intractable pelvic pain that Pain referred to the medial aspect of the thigh is eminently variable and complex as it is often associated Suprapubic pain with multiple, perplexing functional symptoms. Urinary frequency and/or pain on a full bladder Pain occurring after ejaculation In our patient, the delay of diagnosis was probably due to Dyspareunia and/or pain after sexual intercourse the complexity of urogenital symptomatology that led to a Erectile dysfunction misdiagnosis of chronic pelvic pain syndrome, as perineal Normal clinical neurophysiology pain was associated to erectile dysfunction, painful ejacu- lation, and dysuria. In the absence of pathognomonic imaging, laboratory, specificity as it remains particularly useful for assessing and electrophysiology criteria, the diagnosis of PN is pri- motor innervations in the pudendal nerve territory before marily clinical and empirical. Indeed, in the presence of the surgical decompression, but not for localizing the site of essential clinical diagnostic criteria validated by a multidis- compression [5]. In our patient, ENMG of the anal sphinc- ciplinary working party in Nantes (France) and shown in ter was abnormal confirming the diagnosis of pudendal Table 1, PN secondary to nerve entrapment should be nerve compression. suspected. The penile thermal threshold test could more- over be useful to evaluate the somatosensory and auto- Indications for surgery includes a diagnosis of pudendal nomic system functions through the sensitive small fibers entrapment failed conservative treatment (i.e., behavioral stimulation [4]. modifications such as avoiding offending factors that cause pain, physical therapy with specific stretches and Diagnostic techniques, including computed tomography- exercises, and pharmacologic treatment such as anti- guided nerve block and electroneuromyographic (ENMG) epileptics and tricyclic antidepressants) and no long- studies can confirm the diagnosis. lasting improvement after steroid pudendal block [6]. Perineal ENMG may provide various clues in favor of the In the described case, the patient was administered pre- diagnosis. Nevertheless, it has a limited sensitivity and gabalin for a short time, withdrawn because of significant 782 Misdiagnosed Chronic Pelvic Pain
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