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The NIH Catalyst Fostering Communication and Collaboration The nihCatalyst A Publication for NIH Intramural Scientists National Institutes of Health Office of the Director b Volume 15, Issue 4 July-August 2007 Bethesda Makes Another Name for Itself The New Kid in Town CC, NIAID Researchers Uncover New Disease-Causing Bacterium - A buffered-cbarcoal yeast-extract (BCYE) plate showing the very first isolate o/Granulibacter bethesdensis - Ernie Branson Lab Sleuths: (left to right, back row) Patrick Murray, Adrian Zelazny, David E. Greenberg, and Steven Holland; (front row) Li Ding, Frida Stock, and Alexandra Wong staining reveals a Gram gram- by Christopher Wanjek acid-producing bacteria never before negative coccobacillus, but standard associated with human disease. The microbiology laboratory procedures ethesda, the healing bath bacterium’s close are cannot identify the bacterium famed cousins used com- of ancient Jerusalem and present- mercially in the production of vinegar. B day home in Maryland to a cer- The discovery also highlights the tain collection of health institutes, has unique combination of talent and re- acquired one more historic attribute: sources at NIH, in particular the close There’s now a bacterium named after it. relationship among the CC’s microbiolo- The newly identified bacterium is A pair of the newly discovered continued on page 6 bacterium up close called Granulibacter bethesdensis, a trib- to the neighborhood where dis- ute the CONTENTS covery was made. 1 8-12 After a three-year investigation, re- CC-NIAID Team Interest Group searchers at NIAID and the CC deter- Uncovers New Directory mined that this bacterium was the cause Pathogen 13 of lymphadenitis in a patient with the Here’s Looking At Events rare genetic immune disorder known as The New Kid in Town chronic granulomatous disease (CGD). 14 15 2 AOS Viewpoint: The finding underscores bacteria-dis- Gene sequencing and biochemical Guest Editorial— Beware Erosion ease connections that still await discov- OITE Director: Of Freedom of inquiry profile reveal bacterium family, and ery. On Attracting further biochemical tests show the The Best Postdocs 15 19 It took some sleuthing. G. bethes- bacterium can grow on methanol Recently Tenured (right), a clue to its natural environ- densis is difficult to culture and is not 4-5 ment only a new species but constitutes a Exhibit: 20 The Art of Science/ Kids’ Catalyst: images courtesy of Adrian Zelazny whole new genus in a family of acetic- On Track All That Fizz The NIH Catalyst Guest Editorial: From the Director, OITE Postdocs: The Bread and Butter of NIH Research ’e all know what a great postdoc can do in the intramural research program, and heard for a lab. Postdocs can bring new per- from current postdocs, members of FELCOM, and Wspective and energy to our research pro- recent alumni about professional and career de- grams; they can lead the charge in developing velopment opportunities at NIH. They left not new technologies and establishing new collabo- only with a positive impression of NIH in gen- rations; they can help maintain a positive lab en- eral but also with a better appreciation of the vironment and provide outstanding mentoring importance of NIH intramural research. It is for summer students, postbacs, and grad students. hoped that the attendees will share their positive Strong postdocs also can be critical scientific impressions with their colleagues at their home colleagues who help us maintain our focus and institutions, generating even more highly quali- strengthen our research programs. As the CC's fied postdoctoal applicants for NIH openings. Sharon Miigram Patrick Murray describes in the first-page story The event was highly successful from both in this edition of The NIH Catalyst, the NIH is sides; many Pis were excited about the quality "blessed with bright fellows" who indeed enable of the students they had met, and some of the many of the discoveries here. participants are now on campus working as The OITE works in collaboration with NIH ICs postdocs. Ninety-seven percent of festival attend- to oversee the recruitment and training of more ees who responded to a survey at the end of the than 3,800 postdocs, along with hundreds of event said that they would recommend the festi- graduate students, medical students, clinical fel- val to a friend, and 71 percent said they were lows, postbacs, and summer interns. These young likely or very likely to accept a postdoctoral po- scientists often advance to be leaders in their sition at NIH if one were offered. chosen fields. Among NIH training alumni are All participating NIH Pis agreed that this is a several Nobel Prize winners and dozens of mem- cost- and effort-effective way to recruit and in- bers of the National Academy of Sciences. terview potential postdoctoral fellows. That said, identifying postdoc candidates and Plans are well underway for our second NGSRF, recruiting the very best of them to our labs is not which will take place October 11 and 12. More always easy. Many new Ph.D. graduates have than 600 applications were received, and we ex- multiple offers and many outstanding opportu- pect to invite up to 250 students to attend the nities, making postdoc recruitment a frustrating festival. Applicants come from nearly 200 research and time-consuming task. institutions across the country and express inter- I hope to share with you an NIH-wide plan to ests ranging from nanotechnology to global public improve this system, which is off to a good start, health, from tracking proteins to mapping the and call upon you to keep the momentum go- brain, and from molecular biology to behavioral ing. In summer 2005, a committee of IC training studies. directors and representatives of the OITE devel- You can help make the coming festival even oped a plan to address the challenge of recruit- more successful than last year's. Perhaps some ing top postdocs. The committee proposed a two- attendee—or attendees, for that matter—would day festival to the scientific directors that would be a great fit with your lab? I encourage you to bring 250 outstanding advanced graduate students find out by participating in the festival. Go to the to NIH. OITE website In October of 2006, that plan was implemented <www.training.nih.gov> as the first NIH National Graduate Student Re- and follow the “What’s new” link to the NGSRF search Festival (NGSRF). With help from former webpage to post a project and advertise research NIH postdocs and current members of FELCOM, opportunities in your lab. we indeed hosted 250 advanced graduate stu- There is no need to view this as an official job dents for two days of science and networking. posting, with all the regulations that that requires. They were selected from a list of nearly a thou- Also, only festival invitees will have access to sand fine applicants. (See “Graduate Students these postings. We will encourage festival par- Showcase Their Research at NIH—and Think ticipants to contact you directly to set up a meet- about Coming Back for Postdoc Training," The ing during the festival to discuss science, meet Catalyst November-December <http:/ other members of your research group, and learn NIH , 2006; /www.nih. gov/catalyst/2006/06. 1 1.0 1/ about opportunities in your lab. Then, come to page4.html>.) the festival, meet our guests, and share your en- Festival participants presented their work at sev- thusiasm for the intramural research program. eral poster sessions, interviewed with NIH Pis See you at the National Graduate Student Re- for positions, and toured the Bethesda campus. search Festival this fall! NGSRF participants also attended sessions on how —Sharon Miigram NIH works, learned about exciting opportunities Director, OITE 2 — July — August 2007 ‘O Pioneers!’: A Day to Celebrate the Visions of Pioneer Awardees AND ANNOUNCE THE NEWEST RECIPIENTS ne researcher is using methods vative, and potentially Mil DIRK' TOR'S whose cutting-edge re- O rooted in physics and engineering transformative, re- search represents an to understand the emergence of autoim- search. important element of mune diseases. Another is crafting new The goal is to iden- the NIH portfolio.” ways of observing protein folding in- tify scientists whose The symposium will side living cells. And a third aims to ideas could have espe- begin at 8:15 a.m. with build a catalog of the microbial organ- cially significant impact opening remarks by isms inhabiting the human body to help but whose research Zerhouni and Jeremy explain the roles of these communities proposals may be too Berg, NIGMS director, in health and disease. novel or untested to who oversees the Pio- These scientists are among the 13 re- fare well in the tradi- neer Award program. cipients of the 2006 NIH Director’s Pio- tional peer-review pro- The symposium will neer Award who will report on their cess. conclude with a poster research progress at the third annual Researchers at all ca- session and concurrent Pioneer Award Symposium on Wednes- reer levels and working reception from 3:30 to day, September 19. in a broad range of dis- 5:30 p.m. The posters During the event in the Natcher Con- ciplines—from engi- will showcase the work ference Center (Building 45), NIH Di- neering and mathemat- of the 2004, 2005, and rector Elias Zerhouni will also announce ics to the behavioral 2006 Pioneer Award re- the newest group of awardees. The sym- and social sciences cipients and members posium agenda is at are encouraged to ap- A-W-A-R-D of their labs. <http://nihroadmap.nih.gov/ ply, as long as they are For more information pioneer/symposium2007/ interested in exploring biomedically rel- on the 35 awardees and their research index.aspx>.
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