1 Introduction to Epidemiology
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Vpublic HEALTH REPORTS .V .OL~35 NOVEMBER 12, 1920 No
vPUBLIC HEALTH REPORTS .V .OL~35 NOVEMBER 12, 1920 No. 46 A STUDY OF THE RELATION OF FAMILY INCOME AND OTHER ECONOMIC FACTORS TO PELLAGRA INCIDENCE IN SEVEN COTTON-MILL VILLAGES OF SOUTH CAROLINA IN 1916.1 By JOSEPH GOLDBERGER, Surgeon; G. A. WHzzLER, Passed Assistant Surgeon; and EDGAR SYDEI- STRICKEE, Statistician, United States Public Health Service. CONTENT& I. Review of literature. III. Fellagra incidence according to eco- II. Plan aid methods of present study. nomic status. Locality. Discussion. Population. (a) Bad hygiene and sanita- Pellagra incidence. tion. Season. (b) Difference in age and Dietary data. sex composition. Data relating to economic condi- (c) Differences in diet. tions. Differences in incidence Family income. among households. Availability of food supply. Differences in incidence Economic classification. among villages. Method of classification ac- IV. Discussion. cording to economic status. V. Summary and conclusions. Results of classification. VI. References. In the spring of 1916 we began a study of the relation of various factors to-pellagra incidence in certain representative textile-mill communiities of South Carolina. On a varying scale the study was continued through 1917 and 1918. The results of the first year's (1916) study with respect to diet,2 to age, sex, occupation, disabling sickness,3 and to sanitation4 have already been reported. At the present time we wish to record the results of the part of the study dealing with the relation of conditions of an economic nature to the incidence of the disease. L REVIEW OF LITERATURE. A close association of pellagra with poverty has been repeatedly remarked upon since the time of the first recognition of the disease. -
Basic Epidemiology for BPSU Studies
BPSU Study guidance – Basic epidemiology for BPSU studies Dr Simon Lenton on behalf of the Scientific Committee of the British Paediatric Surveillance Unit Updated 07 01 19 BPSU parent bodies: with support from: 1 Contents Introduction ................................................................................................................. 3 Concepts of disease development ..................................................................... 3 Public health surveillance ...................................................................................... 4 Epidemiology ............................................................................................................. 4 Descriptive epidemiology ...................................................................................... 5 Analytic epidemiology ............................................................................................ 5 Triangulation (cross verification) ........................................................................ 6 Capture-recapture .................................................................................................... 6 BPSU research design ............................................................................................. 6 BPSU resources .......................................................................................................... 9 Appendix .................................................................................................................... 10 References ................................................................................................................ -
The Forgotten Plague
AmericanHeritage.com / THE FORGOTTEN PLAGUE http://www.americanheritage.com/articles/magazine/ah/2000/8/... December 2000 Volume 51, Issue 8 THE FORGOTTEN PLAGUE A MURDEROUS DISEASE WAS RAVAGING THE SOUTH. THEN ONE BRAVE AND DETERMINED DOCTOR DISCOVERED THE CURE—AND NOBODY BELIEVED HIM. BY DANIEL AKST Oblivion is a virtue in a disease. Cancer, AIDS, diabetes, and even tuberculosis are too much with us, but hardly anyone knows what pellagra is because the disfiguring deadly illness is virtually nonexistent in America today. For the first third of this century, pellagra was a scourge across the American South, killing thousands and afflicting hundreds of thousands more. Its cause was unknown, and there was no treatment, let alone cure. Victims were shunned like lepers, and by 1914 the sickness was a national scandal. The conquest of pellagra was a triumph of epidemiology over an affliction perhaps as ancient as the Bible, but it was also a triumph of one remarkable man, a medical Sherlock Holmes who fought ignorance, politics, and injustice as well as the disease. Even when the mystery of this preventable killer was solved, pellagra raged for another generation. It was as if the disease mocked science as crucial but insufficient. Pellagra is no longer a national health threat, and that is exactly why the experience of its conqueror is worth retelling. Pellagra was known as the disease of the three D’s: dermatitis, diarrhea, and dementia. Victims suffered scaling, leprous skin, intestinal distress, lethargy, and depression. The trademark symptom was a butterfly rash—an ugly symmetrical blotch that spread across the victim’s face—marking him or her for all to see. -
Early Epidemiological Assessment of the Virulence of Emerging Infectious Diseases: a Case Study of an Influenza Pandemic
Early Epidemiological Assessment of the Virulence of Emerging Infectious Diseases: A Case Study of an Influenza Pandemic Hiroshi Nishiura1*, Don Klinkenberg1, Mick Roberts2, Johan A. P. Heesterbeek1 1 Theoretical Epidemiology, University of Utrecht, Utrecht, The Netherlands, 2 Centre for Mathematical Biology, Institute of Information and Mathematical Sciences, Massey University, Auckland, New Zealand Abstract Background: The case fatality ratio (CFR), the ratio of deaths from an infectious disease to the number of cases, provides an assessment of virulence. Calculation of the ratio of the cumulative number of deaths to cases during the course of an epidemic tends to result in a biased CFR. The present study develops a simple method to obtain an unbiased estimate of confirmed CFR (cCFR), using only the confirmed cases as the denominator, at an early stage of epidemic, even when there have been only a few deaths. Methodology/Principal Findings: Our method adjusts the biased cCFR by a factor of underestimation which is informed by the time from symptom onset to death. We first examine the approach by analyzing an outbreak of severe acute respiratory syndrome in Hong Kong (2003) with known unbiased cCFR estimate, and then investigate published epidemiological datasets of novel swine-origin influenza A (H1N1) virus infection in the USA and Canada (2009). Because observation of a few deaths alone does not permit estimating the distribution of the time from onset to death, the uncertainty is addressed by means of sensitivity analysis. The maximum likelihood estimate of the unbiased cCFR for influenza may lie in the range of 0.16–4.48% within the assumed parameter space for a factor of underestimation. -
Case-Control Studies
Case-control studies Ph.D. course University of Copenhagen March 7, 2005 Aims • Definition of case-control studies • Know the difference between case-control and cohort studies • Describe odds ratio • Know the principles for selection of controls • Be aware of bias and confounding in CC-studies • Describe advantages and disadvantages of CC-studies How are you going to test, if • Amyl nitrite (’Poppers’) is the cause of Kaposi’s sarcoma? – Case-control • Hospitalisation with hip fracture is the cause of lung embolus? – Case-control • Smoking is the cause of lung cancer? – Case-control • Use of childcare centres is a cause of respiratory tract infections? – Cohort study • Viagra acts against erectile dysfunction? – Randomised controlled study 1 The question (hypothesis) determines the method • The method dependes (among others) of –Type ofdisease – Frequency of disease – Characteristics of affected persons – Diagnostic methods Analytical study types • Determination of causes and effects •Observational – Cohort studies –Case-controlstudies • Interventional studies – Randomised, controlled studies Cohort studies • Cohort: Cohors (latin): 1/10 of a legion • Prospective (!) • Starting point a population of healthy TIME Sick Exposed Persons Healthy Population without disease Sick Non-exposed Healthy 2 Outcome in cohort study: Relative risk Sick Healthy Total Exposed A B A + B Non- C D C + D exposed Total A + C B + D A + B + C + D A Relative risk = A + B C C + D With other words: Cohort studies measure • Risk of disease among the exposed compared -
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DRYWALL MUD AND MUDDY DOCTRINE: HOW NOT TO DECIDE A MULTIPLE-EXPOSURE MESOTHELIOMA CASE STEVE C. GOLD* INTRODUCTION Courts have a long history of stuffing policy considerations into the causation element of tort claims.1 High stakes and causal complexity especially elicit such doctrinal misdirection. Toxic tort claims exemplify these traits as much as any type of claim in contemporary tort law. So it comes as no surprise to find judicial policy preferences at or just below the surface in many court opinions that nominally address only whether the plaintiff has proven that the defendant caused the plaintiff’s harm.2 Judicial decisions have consequences. Stare decisis and the influence exerted by some courts magnify the effects. A court sets a precedent in response to a perceived policy imperative. The precedent is then applied (perhaps borrowed by another jurisdiction) in a second case that it doesn’t fit quite as well and is then extended to a third case with unexpected, unjust, or unintelligible results. So it comes as no surprise that when courts misapprehend or misuse factual causation principles, practical concerns are as much at stake as is the theoretical coherence of doctrine. Scholarship has—or should have—consequences, too. Hard problems and novel issues stimulate academic research. Toxic torts have presented plenty of both, and factual causation has proven to be the most durable, controversial, and intractable difficulty in toxic tort cases. So it comes as no surprise that toxic tort causation has generated a sizable body of legal scholarship, some of which has * Professor of Law and Judge Raymond J. -
Joseph Goldberger & the War on Pellagra
Joseph Goldberger & the War on Pellagra Dr. Joseph Goldberger & the War on Pellagra Pellagra no longer stalks the nation as it once did. But during the early part of the 20th-century, pellagra, a disease that results from a diet deficient in niacin, killed many poor Southerners. Dr. Joseph Goldberger, a physician in the U.S. government's Hygienic Laboratory, the predecessor of the National Institutes of Health, discovered the cause of pellagra and stepped on a number of medical toes when his research experiments showed that diet and not germs (the currently held medical theory) caused the disease. He also stepped on Southern pride when he linked the poverty of Southern sharecroppers, tenant farmers, and mill workers to the deficient diet that caused pellagra. Table of Contents Introduction The Early Years: An Immigrant Youth The Bright Young Dr. Goldberger Goldberger and the "Pellagra Germ" Ashes on the Potomac Acknowledgments Photography Credits Display Case in Building One Dr. Joseph Goldberger discovered the cause of pellagra, a disease resulting from a diet deficient in vitamin B. Pellagra killed many poor Southerners in the early part of the 20th century. Introduction Eighty years ago, long before Dr. C. Everett Koop and a new generation of public health professionals suffered social criticism in their public health pronouncements on AIDS, Dr. Joseph Goldberger, Surgeon in the United States Public Health Service, was doing much the same thing. Even as Koop has been critical of personal behavior and social policies that could put populations at risk of acquiring the AIDS virus, Goldberger warned Americans about the crucial link between poor nutrition as the result of poverty and the onset of a scourge known as pellagra. -
Notable Minimum Value of Relative Risk Recognized by Japanese Epidemiologists and Rule of Proof in Civil Trial: Questionnaire Survey
ORIGINAL ARTICLE Notable Minimum Value of Relative Risk Recognized by Japanese Epidemiologists and Rule of Proof in Civil Trial: Questionnaire Survey Minoru Sugita, Shaw Watanabe1, Masao Kanamori and Takashi Izuno Department of Environmental and Occupational Health, Toho University School of Medicine and 1Division of Epidemiology, National Cancer Center Research Institute, Tokyo, Japan (Received for publication on March 11, 1993) Abstract. Members of The Japanese Society of Cancer Epidemiology were questioned about relative risk in cancer epidemiology. The notable minimum value of relative risk recognized by the epidemiologists distributed from 1.1 to 5.0, and the mean and the standard deviation of the notable minimum value were 1.92 and 0.760. In civil litigation of United States a plaintiff must prove one's case by a "preponderance of evidence," which means that a causal relationship between risk factors and a health disturbance to a plaintiff is proved when relative risk is 2.0 or more. The mean value 1.92 of the notable minimum value of relative risk nearly corresponded to the relative risk 2.0, which indicates that opinion of Japanese epidemiologists did not disagree with the rule of the proof in civil litigation of United States. It is mentioned that the standard of the proof should be "high probability" based on "a high level of conviction in the judge's own mind" in Japanese civil trials, and that the "high probability" means that relative risk is 5.0 or more if we dare to quantify the vagueness. This value corresponded to the maximum value of the notable minimum relative risk in the questionnaire to the Japanese epidemiologists. -
Epidemiology and Mental Disorder: a Review
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.27.4.277 on 1 August 1964. Downloaded from J. Neurol. Neurosurg. Psychiat., 1964, 27, 277 Epidemiology and mental disorder: A review MICHAEL SHEPHERD AND BRIAN COOPER From the Institute ofPsychiatry, the Maudsley Hospital, London Though it is now fashionable to speak of the demiology were in circulation before 1914, the year epidemiology of mental illness, this conjunction of in which Goldberger published the first of a series of terms appeared in the literature only rarely before papers which were to demonstrate beyond argument 1949, when it was chosen as the title of a conference the professional epidemiologist's contribution to the organized by the Milbank Memorial Fund to ex- study of mental illness. There were several well- plore common ground between psychiatrists and documented accounts of the so-called psychic epi- public health workers (Milbank Memorial Fund, demics. The development of intelligence testing and 1950). Since then a spate of publications, especially the early studies of suicide had established the value in North America, the Scandinavian countries, and ofthe ecologist's method; and the older psychiatrists, the United Kingdom, has signalized the confluence as Lewis has pointed out, were familiar with such of two medical disciplines. The number of these in- basic epidemiological themes as the relationship vestigations is now so large, and their nature so between mental disorder and migration, isolation, varied, that it is advisable to demarcate the bound- occupation, and socio-economic change (Lewis, aries of psychiatric epidemiology. In Britain this task 1962). has been made easier by the cataloguing of current In view of these promising trends, it is of more Protected by copyright. -
Pellagra Lesson Plan
DISEASE AND SOCIAL POLICY IN THE AMERICAN SOUTH: A Case Study of the Pellagra Epidemic GRADE LEVELS: 10th grade through second year of college/university. SUBJECTS: American History, Health, Rural History. SUMMARY: This lesson presents six activities in which students learn about two epidemics in American history and understand their social, economic, and political contexts, rather than a conventional medical history. In Activity 1 students reflect on their own conceptions about the longevity of Americans today and the factors that influence it. Activity 2 uses a timeline to introduce a case study in its historical context: the early-1900s pellagra epidemic in the American South. In Activities 3 and 4 students use primary sources to learn about the course of the pellagra epidemic. These activities lead up to Activity 5, in which students learn about the socioeconomic conditions in the South that led to the epidemic, write bills, and present their solutions to a model Congress set in 1920. In Activity 6 students use what they learn from the pellagra case study and compare pellagra to the Type II diabetes epidemic affecting the Pima and Tohono O’odham Indians of southern Arizona today. OBJECTIVES: • To learn about the socioeconomic conditions in the American South during the late 19th and early 20th centuries. • To practice analyzing and making deductions based on primary source documents. • To understand the socioeconomic factors that help explain why certain groups of Americans are, on average, sicker than others. TIME ALLOTMENT: Two to five class periods, depending on number of activities implemented. MATERIALS: • The documentary UNNATURAL CAUSES: Is Inequality Making Us Sick? and materials posted on its Web site at http://www.unnaturalcauses.org/ • Articles from The New York Times Archive, available free online: http://www.nytimes.com/ref/membercenter/nytarchive.html • Web access is required during part of Activity 5, but could be avoided by printing out the necessary documents beforehand. -
Epidemiological Bulletin Pan American Health Organization: Celebrating 100 Years of Health
Epidemiological Bulletin Pan American Health Organization: Celebrating 100 Years of Health Vol. 23, No. 3 September 2002 Demographic and Mortality Trends in the Region of the Americas, 1980-2000 This year, the Pan American Health Organization (PAHO) impacts on the population’s mortality profile by both com- celebrates a century of work towards coordinating efforts of municable and non-communicable diseases and external caus- the countries to improve health in the most vulnerable popu- es. It is especially evident in the more susceptible population lations of the Americas. In carrying out this effort, one of the groups such as the poor or elderly. The resulting pattern of essential functions of the Organization during this period mortality magnifies the presence of significant health gaps has been the collection, analysis, and dissemination of infor- between different social groups and geographic areas within mation on health among the Member States. As part of its countries.4 Considering the complex dynamics of the Region’s constitutional mandates, PAHO prepares since 1954 a qua- demographic and health conditions in the Region, the aim of drennial report on the health situation and trends in the Amer- the present article is to describe important markers of the icas. Since 1998, this report is published under the title of “demographic transition” process within the Americas, sin- “Health in the Americas.”1 Its 2002 edition was presented in gling out the changes in relevant indicators in recent years. the previous issue of this Bulletin. This publication contains DATA SOURCES: This analysis is based on PAHO’s core health PAHO’s analysis of different public health aspects of the data, using countries from the American Region as geographic population and the organized responses of the health sector. -
Prisoners As Human Subjects: a Closer Look at the Institute Of
University of California, Hastings College of the Law UC Hastings Scholarship Repository Faculty Scholarship 2010 Prisoners as Human Subjects: A Closer Look at the Institute of Medicine's Recommendations to Loosen Current Restrictions on Using Prisoners in Scientific Research Osagie K. Obasogie UC Hastings College of the Law, [email protected] Follow this and additional works at: http://repository.uchastings.edu/faculty_scholarship Recommended Citation Osagie K. Obasogie, Prisoners as Human Subjects: A Closer Look at the Institute of Medicine's Recommendations to Loosen Current Restrictions on Using Prisoners in Scientific Research, 6 Stan. J. C.R. & C.L. 41 (2010). Available at: http://repository.uchastings.edu/faculty_scholarship/1359 This Article is brought to you for free and open access by UC Hastings Scholarship Repository. It has been accepted for inclusion in Faculty Scholarship by an authorized administrator of UC Hastings Scholarship Repository. For more information, please contact [email protected]. 41_82_OBASOGIE-PRINTER PROOF.DOC 11/9/10 4:30 PM ARTICLE PRISONERS AS HUMAN SUBJECTS: A CLOSER LOOK AT THE INSTITUTE OF MEDICINE’S RECOMMENDATIONS TO LOOSEN CURRENT RESTRICTIONS ON USING PRISONERS IN SCIENTIFIC RESEARCH Osagie K. Obasogie† There have been notable discussions within scientific literature, bioethics scholarship, and the popular press regarding the Institute of Medicine’s (IOM) 2006 recommendations to the Department of Health and Human Services to loosen federal restrictions on using prisoners in biomedical and behavioral research. Yet there has been little dialogue among legal scholars about the recommendations’ potential impact on administrative policy. Supporters point to the growing need for clinical trial participants, ethicists’ changing perspectives, and greater institutional protections, while opponents point to past abuses and their likelihood to reoccur.