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Victor Nizet, M.D

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Victor Nizet, M.D Victor Nizet, M.D. Professor & Vice Chair for Basic Research, Department of Pediatrics Chief, Division of Host-Microbe Systems & Therapeutics University of California, San Diego School of Medicine Professor, Skaggs School of Pharmacy & Pharmaceutical Sciences Biomedical Research Facility II Building, Room 4113 Mail Code 0760, 9500 Gilman Drive, La Jolla, CA 92093-0760 Phone: (858) 534-7408; FAX: (858) 246-1868; email: [email protected] URL: http://nizetlab.ucsd.edu PERSONAL Born Dec 24, 1962 in Augusta, Georgia, USA Married (Christine), Son (Oliver) MAJOR AREAS OF ACADEMIC INTEREST The interest of my laboratory lies in understanding fundamental mechanisms of bacterial pathogenesis and the innate immune system, with a special focus on human streptococcal and staphylococcal infections and emerging antibiotic-resistant pathogens. Using a wide variety of molecular genetic approaches, the laboratory discovers and characterizes bacterial virulence determinants involved in cytotoxicity, adherence, invasion, inflammation, molecular mimicry and resistance to immunologic clearance. In companion studies, we investigate the contribution of host factors such as antimicrobial peptides, cytokines, leukocyte surface receptors, signal transduction pathways, and transcription factors in defense against invasive bacterial infection. Ultimately, we believe the basic discovoeries gained through this platform will inform novel treatment strategies for infectious diseases, including targeted neutralization of microbial virulence phenotypes, pharmacologic augmentation of host immune function, novel monoclonal antibodies and vaccines, and repurposing of FDA-approved drugs to beneficial impact at the host-pathogen interface. My other longstanding academic focus areas include cross-disciplinary research and educational program development, enhancing graduate and postdoctoral training in biological, medical and pharmaceutical sciences, junior faculty development, encouragement of academic-industry collaborations, and public engagement in the sciences. ACADEMIC APPOINTMENTS 2015 – present Vice Chair for Basic Research, Department of Pediatrics, UCSD School of Medicine 2015 – present Chief, Division of Host-Microbe Systems & Therapeutics (new name) 2007 – present Professor of Pediatrics, UCSD School of Medicine 2007 – present Professor of Pharmacy, UCSD Skaggs School of Pharmacy & Pharmaceutical Sciences 2006 – 2015 Chief, Division of Pediatric Pharmacology & Drug Discovery, UCSD School of Medicine 2006 – 2007 Associate Professor, UCSD Skaggs School of Pharmacy & Pharmaceutical Sciences 2003 – 2007 Associate Professor of Pediatrics, UCSD School of Medicine 1997 – 2003 Assistant Professor of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine 1996 – 1997 Acting Instructor, Division of Pediatric Infectious Disease, University of Washington, Seattle, WA CLINICAL TRAINING 1993 – 1996 Pediatric Infectious Diseases Fellowship, Children’s Hospital, Univ. of Washington, Seattle, WA 1992 – 1993 Chief Resident in Pediatrics, Children’s Hospital, Harvard University, Boston, MA 1989 – 1992 Resident in Pediatrics, Children’s Hospital, Harvard University, Boston, MA EDUCATION 1984 – 1989 Stanford University School of Medicine, Doctor of Medicine 1980 – 1984 Reed College, Portland, Oregon, Bachelor of Arts; Major: Biology ACADEMIC HONORS 2017 UCSD Chancellor’s Associates Award for Excellence in Research in Science and Engineering 2013 UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring 1 2013 Rady Children’s Hospital San Diego Award for Excellence in Research 2012 Elected to Fellowship in the American Academy of Microbiology 2010 Elected to Membership in the Association of American Physicians 2008 E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research 2008 Stephen Silberstein Senior Fellow of the American Asthma Foundation 2006 Elected to Membership in the American Society for Clinical Investigation 2006 Elected to the American Pediatric Society 2006 Elected to Faculty of 1000 - Biology 2004 Career Investigator Award, American Lung Association 2004 Established Investigator Award, American Heart Association 2002 Named the 39th Mallinckrodt Scholar by the Edward Mallinckrodt, Jr. Foundation 2002 Pediatric Infectious Diseases Society Young Investigator Award 2002 Elected to the Society for Pediatric Research 2001 UCSD Department of Pediatrics Commitment to Resident Education Award 2000 UCSD Department of Pediatrics Outstanding Faculty Teacher of the Year 1993 Sidney Farber Outstanding Houseofficer Award, Children’s Hospital, Boston 1984 Class of 1922 Award, Reed College, “Most Outstanding Senior Thesis” 1984 Phi Beta Kappa, Reed College UCSD AFFILIATIONS / DIRECTORSHIPS 2017 – present Program Concept Leader, UCSD Collaborative to Halt Antibiotic-Resistant Microbes (CHARM) 2015 – present Vice Chair for Basic Research, Department of Pediatrics 2015 – present Chief, Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics 2014 – present Co-Director, Center for Vaccine Innovation, UCSD Institute for Engineering and Medicine 2013 – present Director, UCSD Center for Immunity, Infection & Inflammation 2011 – present Co-Director, UCSD NICHD-Funded Research Program in Developmental Pharmacology 2009 – present Member, UCSD Clinical & Translational Research Institute 2008 – present Member, UCSD Institute of Engineering in Medicine 2007 – present Co-Director, SSPPS PharmD-PhD Program 2006 – 2015 Chief, Division of Pharmacology & Drug Discovery, Department of Pediatrics UCSD SOM 2006 – 2013 Medical Director, UCSD Clinical Pharmacology & Assay Laboratory 2006 – 2011 Medical Director, UCSD Pediatric Pharmacology Research Unit 2004 – 2006 Director, UCSD Pediatric Infectious Diseases Training Program 2004 – 2016 Track Leader, Microbiology/Immunology, UCSD Biomedical Sciences Program 2003 – present Member, Rebecca and John Moores UCSD Cancer Center 2002 – present Member, Center for Marine Biotechnology & Biomedicine 2002 – present Faculty Member, Biomedical Sciences Graduate Program 2002 – 2008 Faculty Member, UCSD/Burnham Molecular Pathology Graduate Program (merged with BMS) 2002 – present Member, UCSD Glycobiology Research and Training Center SELECTED UCSD UNIVERSITY SERVICE 2018 – Co-Chair, Search Committee for Tenure Track or Tenured Professor for Engineering and Computer Science in Health Sciences, Microbiome Focus 2017 – Chair, Search Committee for Chief of Pediatric Respiratory Medicine 2017— Chair, Search Committee for Chief of Pediatric Infectious Diseases 2016 – Member of Executive Committee, UCSD IRACDA Program 2016—2017 Member, Search Committee for Dean of Graduate Studies 2015 – Executive Committee, UCSD NIH-Funded Chemistry-Biology Interface T-32 Training Program 2014 – 2015 Chair, Search Committee for Senior Faculty in Genomics, Epigenomics & Microbiome Science 2013 – 2016 Member, UCSD Graduate Council 2012 – present Member, UCSD Center for Drug Discovery Innovation Executive Committee 2012 – present Member, UCSD National Center for Leadership in Medicine (NCLAM) Leadership Council 2011 – present Member, Translational Research Alliance Internal Advisory Board, UCSD CTRI 2011 – 2012 Member, Academic Senate Task Force on the Faculty Reward System 2011 – 2012 Chair, Neonatology Division Chief Search Committee, UCSD Department of Pediatrics 2011 – 2013 Member, UCSD Academic Senate Committee on Research 2011 – 2013 Chair, Academic Senate Health Sciences Subcommittee of the UCSD Committee on Research 2010 – present UCSD Medical Scientist Training Program Steering Committee 2 2009 – 2010 Member, Search Committee for Assistant Vice Chancellor for Contracts & Grants Administration 2009 – present Member Skaggs School of Pharmacy & Pharmaceutical Sciences Research Committee 2009 Faculty Committee, UCSD SOM Institutional Self Study Evaluation Task Force 2007 – present Member, UCSD Health Sciences Research Council 2007 – 2010 Chair, UCSD Medical Scientist Training Program Admissions Committee 2007 – 2009 Member-at-Large, UCSD School of Medicine Committee on Educational Policy 2007 – 2009 Chair, Pediatric Respiratory Medicine Division Chief Search Committee 2007 – 2009 Chair, Pediatric Hematology/Oncology Research Director Search Committee 2006 – 2007 Chair, UCSD/RCHSD Pediatrics Intramural Clinical Research Funding Program 2005 – 2007 Member, UCSD/RCHSD Research Task Force 2005 – present Steering Committee, Training Program in Marine Biotechnology SIO/UCSD 2006 – 2008 Chair, Pediatric Nephrology Division Chief Search Committee 2004 – present Member, UCSD Biomedical Sciences Standings, Promotions and Advisory Committee 2004 – present Member, UCSD Biomedical Sciences Program Planning & Executive Committee 2004 – 2006 Vice-Chair, Medical Scientist Training Program Selection Committee 2003 – 2005 Vice- Chair, UCSD School of Medicine Student Affairs Committee SELECTED TEACHING LEADERSHIP ROLES 2011 – 2012 Course Co-Director, SSPPS 249, "Principles of Pharmacology & Physiology" 2008 – present Module Co-Director, BIOM 200, "Microbial Threats and Immune Defense" 2007 – present Course Director, BIOM 253, "Pathogens and Host Defense" PROFESSIONAL SOCIETIES 2013 – present American Association for the Advancement of Science 2012 – present American Academy of Microbiology 2010 – present Association of American Physicians 2006 – present American Society for Clinical Investigation 2006 – present American Pediatric Society 2002 – present Society for Pediatric Research 1993 – present American Society for Microbiology 1993
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