(12) United States Patent (10) Patent No.: US 8,603,508 B2 Norman (45) Date of Patent: *Dec

USOO860.3508B2

(12) United States Patent (10) Patent No.: US 8,603,508 B2 Norman (45) Date of Patent: *Dec. 10, 2013

(54) SKIN MOISTURIZER AND AGE FIGHTING (56) References Cited FORMULA U.S. PATENT DOCUMENTS (71) Applicant: Mary Kay Inc., Dallas, TX (US) 5,663.213 A 9/1997 Jones et al...... 523,105 6,384.104 B1 5/2002 Chang et al. ... 523,105 (72) Inventor: Greg Norman, Bedford, TX (US) 6,451,339 B2 9, 2002 Patel et al...... 424/451 6,488,941 B1 12/2002 Burnier et al. . ... 424/401 (73) Assignee: Mary Kay Inc., Dallas, TX (US) 6,831,107 B2 12/2004 Dederen et al. 514,777 7,146,719 B2 12/2006 Iha ...... 29,830 (*) Notice: Subject to any disclaimer, the term of this 23. R: ck 29, Nations et al. si i patent 1s it, G adjusted under 35 2004/02475434. W4- A1 12/2004 Huertaaranger et al.et al...... 424,59 U.S.C. 154(b) by 0 days. 2005/003.1655 A1 2/2005 Karpov ...... 424/401 2006/0093636 A1 5.2006 Farber ...... 424/401 This patent is subject to a terminal dis- 20080145452 A1 6/2008 Lichtblau et al. ... 424,642 claimer. 2008/O181858 A1 7/2008 Davis et al...... 424,59 2009/0202459 A1 8/2009 Spaulding ...... 424/60 (21) Appl. No.: 13/730,172 FOREIGN PATENT DOCUMENTS (22) Filed: Dec. 28, 2012 EP 1459.736 9, 2004 (65) Prior Publication Data WO WO 97/40816 11, 1997 WO WO 97/40817 11, 1997 US 2013/O121938A1 May 16, 2013 OTHER PUBLICATIONS International Search Report and Written Opinion issued in Interna Related U.S. Application Data tional Patent Application No. PCT/US2011/054633, mailed May 31, (63) Continuation of application No. 13/320,125, filed as 2012. application No. PCT/US2011/054633 on Oct. 3, 2011, * cited by examiner now Pat. No. 8,372,382. (60) Provisional application No. 61/388,893, filed on Oct. Primary Examiner — Anand Desai 1, 2010. Assistant Examiner — Melissa Mercier (74) Attorney, Agent, or Firm — Fulbright & Jaworski LLP (51) Int. Cl. A6 IK 8/02 (2006.01) (57) ABSTRACT (52) U.S. Cl. Disclosed is an oil-in-water emulsion comprising about 2-3% USPC ...... 424/401; 424/70.9 W/w of a combination of glyceryl Stearate, arachidyl alcohol, (58) Field of Classification Search PEG-100 stearate, and arachidylglucoside. None See application file for complete search history. 6 Claims, No Drawings US 8,603,508 B2 1. 2 SKIN MOSTURIZER AND AGE FIGHTING ers (w/w) ranges from 2:1 to 5:1 or from 3:1 to 4:1. The ratio FORMULA of the total amount of the combination of UV absorbing agents (w/w) to the total amount of the combination of CROSS REFERENCE TO RELATED humectant skin conditioning agents (w/w) can range from 1:1 APPLICATIONS to 4:1 or from 2:1 to 3:1. The ratio of the total amount of the combination of UV absorbing agents (w/w) to the total This application claims the benefit of U.S. patent applica amount of the combination non-ionic emulsifiers and non tion Ser. No. 13/320,125, filed Nov. 11, 2011, which is a ionic emulsion stabilizers (w/w) can range from 7:1 to 10:1 or national phase application under 35 U.S.C. S371 of Interna from 8:1 to 9:1. In one embodiment, the emulsion comprises tional Application No. PCT/US2011/054633, filed Oct. 3, 10 45-49% by weight of water, 2-3% by weight of the combina 2011, which claims the benefit of U.S. Provisional Applica tion of glyceryl Stearate, PEG-100 stearate, arachidylgluco tion No. 61/388,893, filed Oct. 1, 2010. The contents of the side, and arachidyl alcohol, 7-9% by weight of the combina referenced application are incorporated into the present appli tion of glycereth-26, glycerin, betaine, panthenol, and cation by reference. allantoin, and 18 to 22% by weight of the combination of 15 homosalate, octisalate, oxybenzone, avobenzone, octoc BACKGROUND OF THE INVENTION rylene, and styrenefacrylates copolymer. The emulsion can include 0.8 to 1% by weight of glyceryl Stearate, 0.5 to 0.7% A. Field of the Invention by weight of arachidyl alcohol, 0.5 to 0.7% by weight of The present invention relates generally to compositions PEG-100 stearate, and 0.1 to 0.3% by weight of arachidyl that can be used to improve the skin's visual appearance. In glucoside. In another aspect, the emulsion can include 3 to 5% particular, the present invention concerns topical skin care by weight of glycereth-26, 2 to 4% by weight of glycerin, 0.1 compositions that include a combination of non-ionic Surfac to 2% by weight of betaine, 0.01 to 1% by weight of pan tants, a combination of humectant skin conditioning agents, thenol, and 0.01 to 1% by weight of allantoin. In still another and a combination of Sunscreen agents. A particular use for aspect, the emulsion can include 4 to 6% by weight of homo the composition can be to moisturize skin or treat dried, 25 salate, 4 to 6% by weight of octisalate, 3 to 5% by weight of chapped, or flaky skin, to treat fine lines and wrinkles, or to oxybenzone, 1 to 3% by weight of avobenzone, 1 to 3% by protect the skin from UV radiation. weight of octocrylene, and 1 to 3% by weight of styrene/ B. Description of Related Art acrylates copolymer. The emulsion can have a non-oily feel Several skin moisturizing compositions are currently avail and/or a silky texture. able. These compositions have various drawbacks ranging 30 Also disclosed is a method for moisturizing skin using any from unpleasant tactile properties (e.g., heavy, greasy, or of the compositions disclosed throughout this specification. Sticky feel), low staying power (e.g., tendency to migrate and The method can include topically applying a composition to pool from point of application or tendency to be easily skin in need of moisturization. In one aspect, the composition removed from the skin via being Subjected to only one wash is applied to dry, flaky, or cracked skin. The composition can ing), insufficient moisturization and/or UV protection capa 35 moisturize the skin for at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, bilities. or 12 hours after topical application. In certain aspects, the composition remains on the skin after the skin has been SUMMARY OF THE INVENTION washed at least two times, which confirms the compositions Substantive properties or abilities to remain on the skin The present invention overcomes deficiencies in the art by 40 despite washing, rubbing, or otherwise touching the compo providing a cosmetically elegant composition that is in the sition while the composition is on the skin. This substantive form of a stable non-ionic oil-in-water formulation having property is a technical achievement in that it can reduce the skin moisturization capabilities. amount of composition that a user ultimately has to apply to In one aspect of the present invention, there is disclosed a skin, continuously protect skin, and/or continuously moistur non-ionic oil-in water emulsion comprising less than 50% by 45 ize skin without fearing that the composition wears-off within weight of water and great than 10%, 20%, 30%, or 40% by 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 hours after application to weight of water, a combination of non-ionic emulsifiers and skin. In this sense, the composition is a Substantive long non-ionic emulsion stabilizers comprising, glyceryl Stearate, lasting composition. The composition can be applied to facial PEG-100 stearate, arachidylglucoside, and arachidyl alco skin, neck skin, arm skin, hand skin, chest skin, back skin, leg hol, a combination of humectant skin conditioning agents 50 skin, feet skin, skin around the periorbital region of the face, comprising glycereth-26, glycerin, betaine, panthenol, and etc. allantoin, and combination of UV absorbing agents compris In one aspect of the present invention there is disclosed a ing homosalate, octisalate, oxybenzone, avobenzone, octoc non-ionic oil-in water emulsion comprising 40-50% by rylene, and styrenefacrylates copolymer, wherein the emul weight of water, a combination of non-ionic emulsifiers and sion is stable and includes an SPF of at least30. The emulsion 55 non-ionic emulsion stabilizers comprising glyceryl Stearate, can have a ratio of the total amount of water (w/w) to the total PEG-100 stearate, arachidylglucoside, and arachidyl alco amount of the combination non-ionic emulsifiers and non hol, a combination of humectant skin conditioning agents ionic emulsion stabilizers (w/w) that ranges from 18:1 to 23:1 comprising glycereth-26, glycerin, betaine, panthenol, and or from 20:1 to 22:1, the ratio of the total amount of water allantoin, and a combination of UV absorbing agents com (w/w) to the total amount of the combination of humectant 60 prising homosalate, octisalate, oxybenzone, avobenzone, skin conditioning agents (w/w) ranges from 4:1 to 8:1 or from octocrylene, and styrenefacrylates copolymer, wherein the 5:1 to 7:1, and/or the ratio of the total amount of water (w/w) emulsion is stable and includes an SPF of at least 30, wherein to the total amount of the combination of UV absorbing the ratio of the total amount of water (w/w) to the total amount agents (w/w) ranges from 2:1 to 3:1. In certain aspects, the of the combination non-ionic emulsifiers and non-ionic emul ratio of the total amount of the combination of humectant skin 65 sion stabilizers (w/w) ranges from 18:1 to 23:1 or from 20:1 conditioning agents (w/w) to the total amount of the combi to 22:1, wherein the ratio of the total amount of water (w/w) nation non-ionic emulsifiers and non-ionic emulsion stabiliz to the total amount of the combination of humectant skin US 8,603,508 B2 3 4 conditioning agents (w/w) ranges from 4:1 to 8:1 or from 5:1 wherein the emulsion is stable and includes an SPF of at least to 7:1, and wherein the ratio of the total amount of water 30. The emulsion can include 0.8 to 1% by weight of glyceryl (w/w) to the total amount of the combination of UV absorbing stearate, 0.5 to 0.7% by weight of arachidyl alcohol, 0.5 to agents (w/w) ranges from 2:1 to 3:1. 0.7% by weight of PEG-100 stearate, 0.1 to 0.3% by weight of In another aspect, there is disclosed a non-ionic oil-in water arachidylglucoside, 3 to 5% by weight of glycereth-26, 2 to emulsion comprising 40-50% by weight of water, a combi 4% by weight of glycerin, 0.1 to 2% by weight of betaine, nation of non-ionic emulsifiers and non-ionic emulsion sta 0.01 to 1% by weight of panthenol, 0.01 to 1% by weight of bilizers comprising a combination of humectant skin condi allantoin, 4 to 6% by weight of homosalate, 4 to 6% by weight tioning agents, and a combination of UV absorbing agents, of octisalate, 3 to 5% by weight of oxybenzone, 1 to 3% by wherein the emulsion is stable and includes an SPF of at least 10 weight of avobenzone, 1 to 3% by weight of octocrylene, and 30, wherein the ratio of the total amount of water (w/w) to the 1 to 3% by weight of styrene? acrylates copolymer. total amount of the combination non-ionic emulsifiers and In one instance, there is disclosed a non-ionic oil-in water non-ionic emulsion stabilizers (w/w) ranges from 18:1 to emulsion comprising, consisting essentially of or consisting 23:1 or from 20:1 to 22:1, wherein the ratio of the total of the ingredients and amounts of Such ingredients disclosed amount of water (w/w) to the total amount of the combination 15 in Table 1 or Table 2, both of which are incorporated into this of humectant skin conditioning agents (w/w) ranges from 4:1 section by reference. to 8:1 or from 5:1 to 7:1, and wherein the ratio of the total In certain embodiments, the compositions are formulated amount of water (w/w) to the total amount of the combination into topical skin care compositions. The compositions can be of UV absorbing agents (w/w) ranges from 2:1 to 3:1. cosmetic compositions. In other aspects, the compositions In still another embodiment there is disclosed a non-ionic can be included in a cosmetic vehicle. Non-limiting examples oil-in water emulsion comprising 40-50% by weight of water, of cosmetic vehicles are disclosed in other sections of this a combination of non-ionic emulsifiers and non-ionic emul specification and are known to those of skill in the art. sion stabilizers comprising glyceryl Stearate, PEG-100 stear Examples of cosmetic vehicles include creams, lotions, and ate, arachidylglucoside, and arachidyl alcohol, a combina ointments. In other non-limiting embodiments, the composi tion of humectant skin conditioning agents comprising 25 tions of the present invention can be included in skin mois glycereth-26, glycerin, betaine, panthenol, and allantoin, and turizing products Such as hand, face, or total body moisturiz a combination of UV absorbing agents comprising homos ers. The compositions can also be formulated for topical skin alate, octisalate, oxybenzone, avobenzone, octocrylene, and application at least 1, 2, 3, 4, 5, 6, 7, or more times a day styrenefacrylates copolymer, wherein the emulsion is stable during use. In other aspects of the present invention, compo and includes an SPF of at least 30, wherein the ratio of the 30 sitions can be storage stable or color stable, or both. It is also total amount of the combination of humectant skin condition contemplated that the viscosity of the composition can be ing agents (w/w) to the total amount of the combination selected to achieve a desired result (e.g., depending on the non-ionic emulsifiers and non-ionic emulsion stabilizers type of composition desired, the Viscosity of Such composi (w/w) ranges from 2:1 to 5:1 or from 3:1 to 4:1, wherein the tion can be from about 1 cps to well over 1 million cps or any ratio of the total amount of the combination of UV absorbing 35 range or integer derivable therein (e.g., 2 cps, 3, 4, 5, 6, 7, 8, agents (w/w) to the total amount of the combination of 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, humectant skin conditioning agents (w/w) ranges from 1:1 to 600, 700, 800, 900, 1000, 2000, 3000, 4000, 5000, 6000, 4:1 or from 2:1 to 3:1, and wherein the ratio of the total 7000, 8000, 9000, 10000, 20000, 30000, 40000, 50000, amount of the combination of UV absorbing agents (w/w) to 60000, 70000, 80000, 90000, 100000, 200000, 300000, the total amount of the combination non-ionic emulsifiers and 40 400000, 500000, 600000, 700000, 800000,900000, 1000000 non-ionic emulsion stabilizers (w/w) ranges from 7:1 to 10:1 cps, etc., as measured on a Brookfield Viscometer using a TC or from 8:1 to 9:1. spindle at 2.5 rpm at 25°C.). In particular embodiments, the Also disclosed is a non-ionic oil-in water emulsion com composition has a viscosity ranging from 14,000 to 30,000 prising, 40-50% by weight of water, a combination of non cps. The compositions in non-limiting aspects can have a pH ionic emulsifiers, a combination of humectant skin condition 45 of about 6 to about 9. In other aspects, the pH can be 1, 2, 3, ing; and a combination of UV absorbing agents, wherein the 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14. In other aspects, the emulsion is stable and includes an SPF of at least 30, wherein compositions can be sunscreens having a Sun protection fac the ratio of the total amount of the combination of humectant tor (SPF) of 1,5, 10, 15, 20, 25, 30,35, 40, 45,50, 55, or more. skin conditioning agents (w/w) to the total amount of the The composition can have a cosmetically or pharmaceuti combination non-ionic emulsifiers and non-ionic emulsion 50 cally elegant feel Such a non-oily, non-greasy, non-sticky, stabilizers (w/w) ranges from 2:1 to 5:1 or from 3:1 to 4:1, non-tacky, and/or silky feel after being applied to skin Such as wherein the ratio of the total amount of the combination of hand skin. UV absorbing agents (w/w) to the total amount of the com Also disclosed is a method of treating or preventing a skin bination of humectant skin conditioning agents (w/w) ranges condition comprising topical application of any one of the from 1:1 to 4:1 or from 2:1 to 3:1, and wherein the ratio of the 55 compositions described in this specification to skin in need total amount of the combination of UV absorbing agents thereof, wherein the topical application of the composition (w/w) to the total amount of the combination non-ionic emul treats the skin condition. In one aspect, the method includes sifiers and non-ionic emulsion stabilizers (w/w) ranges from moisturizing skin or treating or preventing the appearing of 7:1 to 10:1 or from 8:1 to 9:1. dry skin, flaky skin, or chapped skin. In other aspects, it is In even another embodiment there is disclosed a non-ionic 60 contemplated that the compositions can be used to treat or oil-in water emulsion comprising 45-49% by weight of water, prevent skin conditions ranging from pruritus, spider veins, 2-3% by weight of the combination of glyceryl Stearate, PEG lentigo, age spots, senile purpura, keratosis, melasma, 100 Stearate, arachidyl glucoside, and arachidyl alcohol, blotches, fine lines or wrinkles, nodules, Sun damaged skin, 7-9% by weight of the combination of glycereth-26, glycerin, dermatitis (including, but not limited to seborrheic dermatitis, betaine, panthenol, and allantoin, and 18 to 22% by weight of 65 nummular dermatitis, contact dermatitis, atopic dermatitis, the combination of homosalate, octisalate, oxybenzone, exfoliative dermatitis, perioral dermatitis, and stasis derma avobenzone, octocrylene, and styrenefacrylates copolymer, titis), psoriasis, folliculitis, rosacea, acne, impetigo, erysi US 8,603,508 B2 5 6 pelas, erythrasma, eczema, and other inflammatory skin con In one embodiment, compositions of the present invention ditions. In certain non-limiting aspects, the skin condition can can be pharmaceutically or cosmetically elegant. "Pharma be caused by exposure to UV light, age, irradiation, chronic ceutically elegant and/or "cosmetically elegant describes a Sun exposure, environmental pollutants, air pollution, wind, composition that has particular tactile properties which feel cold, heat, chemicals, disease pathologies, Smoking, or lack pleasant on the skin (e.g., compositions that are not too of nutrition. The skin can be facial skin or non-facial skin watery or greasy, compositions that have a silky texture, (e.g., arms, legs, hands, chest, back, feet, etc.). The method compositions that are non-tacky or sticky, etc.). Pharmaceu can further comprise identifying a person in need of skin tically or cosmetically elegant can also relate to the creami treatment. The person can be a male or female. The age of the ness or lubricity properties of the composition or to the mois person can be at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25.30, 10 ture retaining properties of the composition. 35, 40, 45, 50, 55, 60, 65,70, 75,80, 85,90, 95, or more years “Topical application' means to apply or spread a compo old, or any range derivable therein. The method can also sition onto the Surface of keratinous tissue. “Topical skin include topically applying an amount effective to: increase composition' includes compositions suitable for topical the stratum corneum turnover rate of the skin; increase col 15 application on keratinous tissue. Such compositions are typi lagen synthesis in fibroblasts; increase cellular anti-oxidant cally dermatologically-acceptable in that they do not have defense mechanisms (e.g., exogenous additions of anti-oxi undue toxicity, incompatibility, instability, allergic response, dants can bolster, replenish, or prevent the loss of cellular and the like, when applied to skin. Topical skin care compo antioxidants such as catalase and glutathione in skin cells sitions of the present invention can have a selected viscosity (e.g., keratinocytes, melanocytes, langerhans cells, etc.) to avoid significant dripping or pooling after application to which will reduce or prevent oxidative damage to the skin, skin. cellular, proteins, and lipids); inhibit melanin production in "Keratinous tissue' includes keratin-containing layers dis melanocytes; reduce or prevent oxidative damage to skin posed as the outermost protective covering of mammals and (including reducing the amount lipid peroxides and/or protein includes, but is not limited to, skin, hair and nails. oxidation in the skin). In certain embodiments, compositions 25 The terms “mixture.” “mix,” and “mixing or any variants of the present invention can decrease the amount of internal of these terms, when used in the claims and/or specification oxidation and/or external oxidative damage in a cell. In other includes, stirring, blending, dispersing, milling, homogeniz aspects, the compositions can increase collagen synthesis in a ing, and other similar methods. The mixing of the compo cell. The compositions can also reduce skin inflammation, nents or ingredients of the disclosed compositions can form Such as by reducing inflammatory cytokine production in a 30 into a solution. In other embodiments, the mixtures may not cell. Non-limiting examples of Such cells include human epi form a solution. The ingredients/components can also exist as dermal keratinocyte, human fibroblast dermal cell, human undissolved colloidal suspensions. melanocytes, three dimensional human cell-derived in vitro The term “about' or “approximately are defined as being tissue equivalents comprising human keratinocytes, human close to as understood by one of ordinary skill in the art, and fibroblasts, or human melanocytes, or any combination 35 in one non-limiting embodiment the terms are defined to be thereof (e.g., combination of human keratinocytes and human within 10%, preferably within 5%, more preferably within fibroblasts or a combination of human keratinocytes and 1%, and most preferably within 0.5%. human melanocytes). The term “substantially' and its variations are defined as Also contemplated are kits that includes the compositions being largely but not necessarily wholly what is specified as of the present invention. In certain embodiments, the compo 40 understood by one of ordinary skill in the art, and in one sition is comprised in a container. The container can be a non-limiting embodiment Substantially refers to ranges bottle, dispenser, or package. The container can dispense a within 10%, within 5%, within 1%, or within 0.5%. pre-determined amount of the composition. In certain The terms “inhibiting or “reducing or any variation of aspects, the compositions is dispensed in a spray, dollop, or these terms, when used in the claims and/or the specification liquid. The container can include indicia on its surface. The 45 includes any measurable decrease or complete inhibition to indicia can be a word, an abbreviation, a picture, or a symbol. achieve a desired result. Also contemplated is a product comprising a composition The term “effective,” as that term is used in the specifica of the present invention. In non-limiting aspects, the product tion and/or claims, means adequate to accomplish a desired, can be a cosmetic product. The cosmetic product can be those expected, or intended result. described in other sections of this specification or those 50 The use of the word “a” or “an' when used in conjunction known to a person of skill in the art. Non-limiting examples of with the term “comprising in the claims and/or the specifi products include a moisturizer, a cream, a lotion, a skin Soft cation may mean "one.” but it is also consistent with the ener, a foundation, a night cream, a lipstick, a cleanser, a meaning of “one or more.” “at least one and “one or more toner, a Sunscreen, a mask, or an anti-aging product. than one.” The compositions and methods for their use can "com 55 The use of the term 'or' in the claims is used to mean prise.” “consist essentially of” or “consist of any of the “and/or unless explicitly indicated to refer to alternatives ingredients disclosed throughout the specification. When the only or the alternatives are mutually exclusive, although the transitional phrase “consist(s) essentially of is used in a disclosure Supports a definition that refers to only alternatives claim, the basic and novel characteristic of the claimed com and “and/or.” position is its ability to remain stable, moisturize skin, and 60 As used in this specification and claim(s), the words "com protect skin from UV radiation, while also having a cosmeti prising (and any form of comprising. Such as “comprise' and cally elegant feel. “comprises”), “having (and any form of having, such as It is contemplated that any embodiment discussed in this “have” and “has'), “including (and any form of including, specification can be implemented with respect to any method such as “includes and “include’) or “containing (and any or composition of the invention, and vice versa. Furthermore, 65 form of containing, Such as “contains and “contain’) are compositions of the invention can be used to achieve methods inclusive or open-ended and do not exclude additional, unre of the invention. cited elements or method steps. US 8,603,508 B2 7 8 Other objects, features and advantages of the present In particular embodiments, the inventor discovered that a invention will become apparent from the following detailed particular combination of non-ionic emulsifiers and stabiliz description. It should be understood, however, that the ers works well in the context of the disclosed stable oil-in detailed description and the examples, while indicating spe water emulsions. This combination includes glyceryl Stear cific embodiments of the invention, are given by way of 5 ate, PEG-100 stearate, arachidyl glucoside, and arachidyl illustration only. Additionally, it is contemplated that changes alcohol. It was also discovered that a ratio of approximately and modifications within the spirit and scope of the invention 18:1 to 23:1 or from 20:1 to 22:1 of the total amount of water will become apparent to those skilled in the art from this (w/w) to the total amount of this particular combination non detailed description. ionic emulsifiers and non-ionic emulsion stabilizers works 10 Surprisingly well. DESCRIPTION OF ILLUSTRATIVE C. Humectant Skin Conditioning Agents EMBODIMENTS Humectant skin conditioning agents include ingredients that are capable of increasing the water content of the top In today's image conscious Society, people are continually layers of skin by retaining water present in the composition looking for a product that can improve the visual appearance 15 and also absorbing or attracting water from air. Non-limiting of their skin. For instance, symptoms associated with dry skin examples of humectants that can be used in the context of the (e.g., flaky skin, dried or rough tactile quality, cracked skin, present invention include those listed in the International dehydrated skin, itchy skin, or red or erythemic skin) is asso Cosmetic Ingredient Dictionary Handbook, 12" Edition ciated with unattractive skin. Previous attempts to create a (2008), Vol. 3, pages 3236-3239, which is incorporated by composition to treat or prevent dry skin have been meet with 20 reference. numerous drawbacks ranging from compositions having In particular embodiments, the inventor discovered that a unpleasant tactile properties (e.g., heavy, greasy, or sticky particular combination of humectant works well in the con feel), low staying power (e.g., tendency to migrate and pool text of the disclosed stable oil-in-water emulsions. This com from point of application or tendency to be easily removed bination includes glycereth-26, glycerin, betaine, panthenol, from the skin via being Subjected to only one washing), or 25 and allantoin. It was also discovered that a ratio of approxi insufficient moisturization or UV protection capabilities. mately 4:1 to 8:1 or from 5:1 to 7:1 of the total amount of The present invention is an effective alternative to the cur water (w/w) to the total amount of this particular combination rent skin moisturizers on the market. In one non-limiting humectants works Surprisingly well. aspect, the compositions of the present invention is formu D. UV Absorbing Agents lated as a stable non-ionic oil-in-water emulsion having 30 UV absorbing agents are capable of protecting skin from water, a combination of non-ionic emulsifiers and non-ionic UV radiation (e.g., UVA, UVB, and/or UVC radiation). Non emulsion stabilizers, a combination of humectant skin con limiting examples of UV Absorbing Agents that can be used ditioning agents, and a combination of UV absorbing agents. in the context of the present invention include those listed in This combination of features Surprising produces a dermato the International Cosmetic Ingredient Dictionary Handbook, logically acceptable composition that has a cosmetically 35 12" Edition (2008), Vol. 3, pages 3236-3239, which is incor elegant feel and is capable of moisturizing skin and protecting porated by reference. Such examples include chemical and the skin from UV radiation. These and other aspect of the physical Sunblocks. Non-limiting examples of chemical Sun present invention are described in further detail below. blocks that can be used include para-aminobenzoic acid A. Water (PABA), PABA esters (glyceryl PABA, amyldimethyl PABA The oil-in-water emulsions of the present invention include 40 and octyldimethyl PABA), butyl PABA, ethyl PABA, ethyl water. One of the benefits of water is that it is capable of dihydroxypropyl PABA, benzophenones (oxybenzone, producing a composition having a light, non-greasy feel. An Sulisobenzone, benzophenone, and benzophenone-1 through additional benefit is that water is a natural ingredient that can 12), cinnamates (and octyl methoxycinnamate, isoamyl hydrate the skin. In one non-limiting aspect of the present p-methoxycinnamate, octylmethoxy cinnamate, cinoxate, invention, the oil-in-water emulsions can include less than 45 diisopropyl methyl cinnamate, DEA-methoxycinnamate, 50% (w/w) of water, yet still remain stable and produce a ethyl diisopropylcinnamate, glyceryl octanoate dimethoxy cosmetically elegant feel when applied to skin. The inventor cinnamate and ethyl methoxycinnamate), cinnamate esters, has Surprisingly discovered that a combination of non-ionic salicylates (homomethyl salicylate, benzyl salicylate, glycol emulsifiers and non-ionic emulsion stabilizers, a combination salicylate, isopropylbenzyl salicylate, etc.), anthranilates, of humectant skin conditioning agents, and a combination of 50 ethyl urocanate, homosalate, dibenzoylmethane derivatives UV absorbing agents can effectively produce a stable oil-in (e.g., avobenzone), styrenefacrylates copolymer (e.g., SUN water emulsion have less than 50% (w/w) of water, yet still SPHERESTM sold by Rohm and Haas), octocrylene, etc. Non have a cosmetically elegant feel and effective skin moistur limiting examples of physical Sunblocks include, kaolin, talc, ization and UV protection properties. petrolatum and metal oxides (e.g., titanium dioxide and Zinc B. Non-Ionic Emulsifiers and Non-Ionic Emulsion Stabiliz- 55 oxide). CS In particular embodiments, the inventor discovered that a Non-ionic emulsifiers are neutrally charged molecules that particular combination of UV absorbing agents well in the have the ability to emulsify two immiscible phases such as context of the disclosed stable oil-in-water emulsions. This water and oil. Non-ionic emulsion stabilizers are also neu combination includes homosalate, octisalate, oxybenzone, trally charged molecules. These molecules can be used to 60 avobenzone, octocrylene, and styrenefacrylates copolymer. It stabilize an emulsion. Non-limiting examples of non-ionic was also discovered that a ratio of approximately 2:1 to 3:1 of emulsifiers and stabilizers that can be used in the context of the total amount of water (w/w) to the total amount of this the present invention include those listed in the International particular combination of UV absorbing agents (w/w) pro Cosmetic Ingredient Dictionary Handbook, 12" Edition duces a stable emulsion having an SPF of approximately 30. (2008) and in PCT Publications WO 97/40816 and WO 65 E. Compositions of the Present Invention 97/40817, the contents of which are all incorporated by ref While particular embodiments and amounts are described CCC. throughout this specification, it is contemplated that the com US 8,603,508 B2 10 positions of the present invention can include water, a com F. Vehicles bination of non-ionic emulsifiers and non-ionic emulsion sta The compositions of the present invention can be incorpo bilizers, a combination of humectant skin conditioning rated into all types of cosmetically and dermalogically agents, and a combination of UV absorbing agents can be acceptable vehicles. Non-limiting examples of suitable vehicles include creams, lotions, and ointments. Variations included in any combination and any amount. Additionally, and other appropriate vehicles will be apparent to the skilled the compositions can include any number of combinations of artisan and are appropriate for use in the present invention. In additional ingredients described throughout this specifica certain aspects, it is important that the concentrations and tion. The concentrations of any ingredient within the compo combinations of the compounds, ingredients, and agents be sitions can vary. In non-limiting embodiments, for example, selected in Such a way that the combinations are chemically the compositions can comprise, consisting essentially of, or 10 compatible and do not form complexes which precipitate consist of in their final form, for example, at least about from the finished product. 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, It is also contemplated that ingredients identified through 0.0007%, 0.0008%, 0.0009%, 0.0010%, 0.0011%, 0.0012%, out this specification, including but not limited to water, the combination of non-ionic emulsifiers and non-ionic emulsion 0.0013%, 0.0014%, 0.0015%, 0.0016%, 0.0017%, 0.0018%, 15 stabilizers, the combination of humectant skin conditioning 0.001.9%, 0.0020%, 0.0021%, 0.0022%, 0.0023%, 0.0024%, agents, and the combination of UV absorbing agents can be 0.0025%, 0.0026%, 0.0027%, 0.0028%, 0.0029%, 0.0030%, individually or combinatorially encapsulated for delivery to a 0.0031%, 0.0032%, 0.0033%, 0.0034%, 0.0035%, 0.0036%, target area Such as skin. Non-limiting examples of encapsu 0.0037%, 0.0038%, 0.0039%, 0.0040%, 0.0041%, 0.0042%, lation techniques include the use of liposomes, Vesicles, and/ 0.0043%, 0.0044%, 0.0045%, 0.0046%, 0.0047%, 0.004.8%, or nanoparticles (e.g., biodegradable and non-biodegradable 0.0049%, 0.0050%, 0.0051%, 0.0052%, 0.0053%, 0.0054%, colloidal particles comprising polymeric materials in which 0.0055%, 0.0056%, 0.0057%, 0.0058%, 0.0059%, 0.0060%, the ingredient is trapped, encapsulated, and/or absorbed— 0.0061%, 0.0062%, 0.0063%, 0.0064%, 0.0065%, 0.0066%, examples include nanospheres and nanocapsules) that can be 0.0067%, 0.0068%, 0.0069%, 0.0070%, 0.0071%, 0.0072%, used as delivery vehicles to deliver the ingredient to skin (see, 0.0073%, 0.0074%, 0.0075%, 0.0076%, 0.0077%, 0.0078%, 25 e.g., U.S. Pat. No. 6,387,398: U.S. Pat. No. 6,203,802; U.S. 0.0079%, 0.0080%, 0.0081%, 0.0082%, 0.0083%, 0.0084%, Pat. No. 5.41 1,744: Kreuter 1998). 0.0085%, 0.0086%, 0.0087%, 0.0088%, 0.0089%, 0.0090%, G. Cosmetic Products and Articles of Manufacture 0.0091%, 0.0092%, 0.0093%, 0.0094%, 0.0095%, 0.0096%, The composition of the present invention can also be used 0.0097%, 0.0098%, 0.0099%, 0.01.00%, 0.0200%, 0.0250%, in many cosmetic products including, but not limited to, 0.0275%, 0.0300%, 0.0325%, 0.0350%, 0.0375%, 0.04.00%, 30 moisturizing creams or lotions (e.g., hand creams or lotions, 0.0425%, 0.0450%, 0.0475%, 0.0500%, 0.0525%, 0.0550%, face creams or lotions, neck and décolleté creams or lotions, 0.0575%, 0.0600%, 0.0625%, 0.0650%, 0.0675%, 0.0700%, body creams or lotions, etc.), sunscreen products, sunless 0.0725%, 0.0750%, 0.0775%, 0.0800%, 0.0825%, 0.0850%, skin tanning products, hair products, finger nail products, 0.0875%, 0.0900%, 0.0925%, 0.0950%, 0.0975%, 0.1000%, softeners, day lotions, gels, ointments, foundations, night 0.1250%, 0.1500%, 0.1750%, 0.2000%, 0.2250%, 0.2500%, 35 creams, lipsticks, cleansers, toners, masks, skin-whiteners/ 0.2750%, 0.3000%, 0.3250%, 0.3500%, 0.3750%, 0.4000%, brighteners, or other known cosmetic products or applica 0.4250%, 0.4500%, 0.4750%, 0.5000%, 0.5250%, 0.0550%, tions. Additionally, the cosmetic products can be formulated 0.5750%, 0.6000%, 0.6250%, 0.6500%, 0.6750%, 0.7000%, as leave-on or rinse-off products. In certain aspects, the com 0.7250%, 0.7500%, 0.7750%, 0.8000%, 0.8250%, 0.8500%, positions of the present invention are stand-alone products. 0.8750%, 0.9000%, 0.925.0%, 0.9500%, 0.9750%, 1.0%, 40 H. Additional Ingredients 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, In addition to the water, the combination of non-ionic 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, emulsifiers and non-ionic emulsion stabilizers, the combina 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, tion of humectant skin conditioning agents, and the combi 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, nation of UV absorbing agents disclosed throughout this 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 45 specification, compositions of the present invention can 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, include additional ingredients such as cosmetic ingredients 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, and pharmaceutical active ingredients. Non-limiting 7.4%, 7.5%, 7.6%, 7.7%, 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, examples of these additional ingredients are described in the 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, following Subsections. 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 50 1. Cosmetic Ingredients 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, The CTFA International Cosmetic Ingredient Dictionary 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, and Handbook (2004 and 2008) describes a wide variety of 35%, 40%, 45%, 50%, 60%, 65%, 70%, 75%, 80%, 85%, non-limiting cosmetic ingredients that can be used in the 90%. 95%, or 99% or any range derivable therein. In non context of the present invention. Examples of these ingredient limiting aspects, the percentage can be calculated by weight 55 classes include: fragrances (artificial and natural), dyes and or volume of the total composition. A person of ordinary skill color ingredients (e.g., Blue 1, Blue 1 Lake, Red 40, titanium in the art would understand that the concentrations can vary dioxide, D&C blue no. 4, D&C green no. 5, D&C orange no. depending on the addition, Substitution, and/or Subtraction of 4, D&C red no. 17, D&C red no. 33, D&C violet no. 2, D&C ingredients in a given composition. yellow no. 10, and D&C yellow no. 11), adsorbents, lubri The disclosed compositions of the present invention may 60 cants, solvents, moisturizers (including, e.g., emollients, also include various antioxidants to retard oxidation of one or humectants, film formers, occlusive agents, and agents that more components. Additionally, the prevention of the action affect the natural moisturization mechanisms of the skin), of microorganisms can be brought about by preservatives water-repellants, UV absorbers (physical and chemical Such as various antibacterial and antifungal agents, including absorbers such as paraaminobenzoic acid (“PABA) and cor but not limited to parabens (e.g., methylparabens, propylpa 65 responding PABA derivatives, titanium dioxide, zinc oxide, rabens), chlorobutanol, phenol, Sorbic acid, thimerosal or etc.), essential oils, vitamins (e.g. A, B, C, D, E, and K), trace combinations thereof. metals (e.g. Zinc, calcium and selenium), anti-irritants (e.g. US 8,603,508 B2 11 12 steroids and non-steroidal anti-inflammatories), botanical etable oil, hydrolyzed collagen, hydrolyzed elastin, hydro extracts (e.g. aloe Vera, chamomile, cucumber extract, ginkgo lyzed glycosaminoglycans, hydrolyzed keratin, hydrolyzed biloba, ginseng, and rosemary), anti-microbial agents, anti soy protein, hydroxylated lanolin, hydroxyproline, isocetyl oxidants (e.g., BHT and tocopherol), chelating agents (e.g., Stearate, isocetyl Stearoyl Stearate, isodecyl oleate, isopropyl disodium EDTA and tetrasodium EDTA), preservatives (e.g., isostearate, isopropyllanolate, isopropyl myristate, isopropyl methylparaben and propylparaben), pH adjusters (e.g., palmitate, isopropyl Stearate, isostearamide DEA, isostearic Sodium hydroxide and citric acid), absorbents (e.g., alumi acid, isostearyl lactate, isostearyl neopentanoate, jasmine num starch octenylsuccinate, kaolin, corn starch, oat starch, (jasminum officinale) oil, jojoba (buxus chinensis) oil, kelp, cyclodextrin, talc, and Zeolite), skin bleaching and lightening kukui (aleurites moluccana) nut oil, lactamide MEA, laneth agents (e.g., hydroquinone and niacinamide lactate), humec 10 16, laneth-10 acetate, lanolin, lanolin acid, lanolin alcohol, tants (e.g., Sorbitol, urea, and manitol), exfoliants, water lanolin oil, lanolin wax, lavender (lavandula angustifolia) oil, proofing agents (e.g., magnesium/aluminum hydroxide Stear lecithin, lemon (citrus medica limonum) oil, linoleic acid, ate), skin conditioning agents (e.g., aloe extracts, allantoin, linolenic acid, macadamia ternifolia nut oil, maltitol, matri bisabolol, ceramides, dimethicone, hyaluronic acid, and caria (chamomilla recutita) oil, methyl glucose sesquistear dipotassium glycyrrhizate). Non-limiting examples of some 15 ate, methylsilanol PCA, mineral oil, mink oil, mortierella oil, of these ingredients are provided in the following Subsec myristyl lactate, myristyl myristate, myristyl propionate, tions. neopentyl glycol dicaprylate/dicaprate, octyldodecanol, a. Moisturizing Agents octyldodecyl myristate, octyldodecyl Stearoyl Stearate, octyl Non-limiting examples of moisturizing agents that can be hydroxyStearate, octyl palmitate, octyl salicylate, octyl Stear used with the compositions of the present invention include ate, oleic acid, olive (olea europaea) oil, orange (citrus auran amino acids, chondroitin Sulfate, diglycerin, erythritol, fruc tium dulcis) oil, palm (elaeis guineensis) oil, palmitic acid, tose, glucose, glycerin, glycerol polymers, glycol, 1.2.6-hex pantethine, panthenol, panthenyl ethyl ether, paraffin, PCA, anetriol, honey, hyaluronic acid, hydrogenated honey, hydro peach (prunus persica) kernel oil, peanut (arachis hypogaea) genated Starch hydrolysate, inositol, lactitol, maltitol, oil, PEG-8 C12-18 ester, PEG-15 cocamine, PEG-150 dis maltose, mannitol, natural moisturizing factor, PEG-15 25 tearate, PEG-60 glyceryl isostearate, PEG-5 glyceryl Stear butanediol, polyglyceryl Sorbitol, salts of pyrollidone car ate, PEG-30 glyceryl Stearate, PEG-7 hydrogenated castor boxylic acid, potassium PCA, propylene glycol, Sodium glu oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated curonate, sodium PCA, Sorbitol. Sucrose, trehalose, urea, and castor oil, PEG-20 methyl glucose sesquistearate, PEG40 xylitol. sorbitan peroleate, PEG-5 soy sterol, PEG-10 soy sterol, Other examples include acetylated lanolin, acetylated 30 PEG-2 stearate, PEG-8 stearate, PEG-20 stearate, PEG-32 lanolin alcohol, alanine, algae extract, aloe barbadensis, aloe stearate, PEG-40 stearate, PEG-50 stearate, PEG-100 stear barbadensis extract, aloe barbadensis gel, althea officinalis ate, PEG-150 stearate, pentadecalactone, peppermint (men extract, apricot (prunus armeniaca) kernel oil, arginine, argi tha piperita) oil, petrolatum, phospholipids, polyamino Sugar nine aspartate, arnica montana extract, aspartic acid, avocado condensate, polyglyceryl-3 diisoStearate, polyduaternium (persea gratissima) oil, barrier sphingolipids, butyl alcohol, 35 24, polysorbate 20, polysorbate 40, polysorbate 60, polysor beeswax, behenyl alcohol, beta-sitosterol, birch (betula alba) bate 80, polysorbate 85, potassium myristate, potassium bark extract, borage (borago officinalis) extract, butcherb palmitate, propylene glycol, propylene glycol dicaprylate/ room (ruscus aculeatus) extract, butylene glycol, calendula dicaprate, propylene glycol dioctanoate, propylene glycol officinalis extract, calendula officinalis oil, candelilla (eu dipelargonate, propylene glycol laurate, propylene glycol phorbiacerifera) wax, canola oil, caprylic/capric triglyceride, 40 stearate, propylene glycol stearate SE, PVP. pyridoxine cardamon (elettaria cardamomum) oil, carnauba (copernicia dipalmitate, retinol, retinyl palmitate, rice (oryza sativa) bran cerifera) wax, carrot (daucus carota sativa) oil, castor (ricinus oil, RNA, rosemary (roSmarinus officinalis) oil, rose oil, saf communis) oil, ceramides, ceresin, ceteareth-5, ceteareth-12, flower (carthamus tinctorius) oil, sage (salvia officinalis) oil, ceteareth-20, cetearyl octanoate, ceteth-20, ceteth-24, cetyl sandalwood (Santalum album) oil, serine, serum protein, acetate, cetyl octanoate, cetyl palmitate, chamomile (anthe 45 sesame (sesamum indicum) oil, shea butter (butyrospermum mis nobilis) oil, cholesterol, cholesterol esters, cholesteryl parkii), silk powder, sodium chondroitin Sulfate, sodium hydroxy Stearate, citric acid, clary (Salvia Sclarea) oil, cocoa hyaluronate, sodium lactate, Sodium palmitate, Sodium PCA, (theobroma cacao) butter, coco-caprylate/caprate, coconut Sodium polyglutamate, soluble collagen, Sorbitan laurate, (cocos nucifera) oil, collagen, collagenamino acids, corn (Zea Sorbitan oleate, Sorbitan palmitate, Sorbitan sesquioleate, Sor mays)oil, fatty acids, decyl oleate, dimethicone copolyol. 50 bitan Stearate, Sorbitol, Soybean (glycine Soja) oil, sphin dimethiconol, dioctyl adipate, dioctyl Succinate, dipen golipids, squalane, squalene, Stearamide MEA-stearate, taerythrity1 hexacaprylate/hexacaprate, DNA, erythritol, Stearic acid, Stearoxy dimethicone, Stearoxytrimethylsilane, ethoxydiglycol, ethyl linoleate, eucalyptus globulus oil, Stearyl alcohol, Stearyl glycyrrhetinate, Stearyl heptanoate, evening primrose (oenothera biennis) oil, fatty acids, gera Stearyl Stearate, Sunflower (helianthus annuus) seed oil, Sweet nium maculatum oil, glucosamine, glucose glutamate, 55 almond (prunus amygdalus dulcis) oil, synthetic beeswax, glutamic acid, glycereth-26, glycerin, glycerol, glyceryl dis tocopherol, tocopheryl acetate, tocopheryllinoleate, tribehe tearate, glyceryl hydroxy Stearate, glyceryl laurate, glyceryl nin, tridecyl neopentanoate, tridecyl Stearate, triethanola linoleate, glyceryl myristate, glyceryl oleate, glyceryl Stear mine, tristearin, urea, vegetable oil, water, waxes, wheat (triti ate, glyceryl Stearate SE, glycine, glycol Stearate, glycol cum Vulgare) germ oil, and ylangylang (cananga odorata) oil. Stearate SE, glycosaminoglycans, grape (vitis vinifera) seed 60 b. Antioxidants oil, hazel (corylus americana) nut oil, hazel (corylus avellana) Non-limiting examples of antioxidants that can be used nut oil, hexylene glycol, hyaluronic acid, hybrid safflower with the compositions of the present invention include acetyl (carthamus tinctorius) oil, hydrogenated castor oil, hydroge cysteine, ascorbic acid polypeptide, ascorbyl dipalmitate, nated coco-glycerides, hydrogenated coconut oil, hydroge ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascor nated lanolin, hydrogenated lecithin, hydrogenated palm 65 byl stearate. BHA, BHT, t-butyl hydroquinone, cysteine, cys glyceride, hydrogenated palm kernel oil, hydrogenated Soy teine HCI, diamylhydroquinone, di-t-butylhydroquinone, bean oil, hydrogenated tallow glyceride, hydrogenated veg dicetyl thiodipropionate, dioleyl tocopheryl methylsilanol, US 8,603,508 B2 13 14 disodium ascorbyl Sulfate, distearyl thiodipropionate, dient Dictionary (incorporated by reference) as cyclic dim ditridecylthiodipropionate, dodecyl gallate, erythorbic acid, ethyl polysiloxane compounds and a mixture of fully methy esters of ascorbic acid, ethyl ferulate, ferulic acid, gallic acid lated linear siloxane polymers end-blocked with esters, hydroquinone, isooctylthioglycolate, kojic acid, mag trimethylsiloxy units, respectively. Other non-limiting Vola nesium ascorbate, magnesium ascorbyl phosphate, methylsi tile silicone oils that can be used in the context of the present lanol ascorbate, natural botanical anti-oxidants such as green invention include those available from General Electric Co., tea or grape seed extracts, nordihydroguaiaretic acid, octyl Silicone Products Div., Waterford, N.Y. and SWS Silicones gallate, phenylthioglycolic acid, potassium ascorby1 toco Div. of Stauffer Chemical Co., Adrian, Mich. pheryl phosphate, potassium sulfite, propyl gallate, quinones, e. Essential Oils roSmarinic acid, Sodium ascorbate, Sodium bisulfite, sodium 10 erythorbate, sodium metabisulfite, sodium sulfite, superoxide Essential oils include oils derived from herbs, flowers, dismutase, Sodium thioglycolate, Sorbityl furfural, thiodigly trees, and other plants. Such oils are typically present as tiny col, thiodiglycolamide, thiodiglycolic acid, thioglycolic acid, droplets between the plants cells, and can be extracted by thiolactic acid, thiosalicylic acid, tocophereth-5, toco several method known to those of skill in the art (e.g., steam phereth-10, tocophereth-12, tocophereth-18, tocophereth-50, 15 distilled, enfleurage (i.e., extraction by using fat), maceration, tocopherol, tocophersolan, tocopheryl acetate, tocopheryl Solvent extraction, or mechanical pressing). When these types linoleate, tocopheryl nicotinate, tocopheryl Succinate, and ofoils are exposed to air they tend to evaporate (i.e., a Volatile tris(nonylphenyl)phosphite. oil). As a result, many essential oils are colorless, but with age c. Structuring Agents they can oxidize and become darker. Essential oils are In other non-limiting aspects, the compositions of the insoluble in water and are soluble in alcohol, ether, fixed oils present invention can include a structuring agent. Structuring (vegetal), and other organic solvents. Typical physical char agent, in certain aspects, assist in providing rheological char acteristics found in essential oils include boiling points that acteristics to the composition to contribute to the composi vary from about 160° to 240° C. and densities ranging from tion's stability. In other aspects, structuring agents can also about 0.759 to about 1.096. function as an emulsifier or Surfactant. Non-limiting 25 Essential oils typically are named by the plant from which examples of structuring agents include Stearic acid, palmitic the oil is found. For example, rose oil or peppermint oil are acid, Stearyl alcohol, cetyl alcohol, behenyl alcohol, Stearic derived from rose or peppermint plants, respectively. Non acid, palmitic acid, the polyethylene glycol ether of Stearyl limiting examples of essential oils that can be used in the alcohol having an average of about 1 to about 21 ethylene context of the present invention include sesame oil, macad oxide units, the polyethylene glycol ether of cetyl alcohol 30 amia nut oil, tea tree oil, evening primrose oil, Spanish sage having an average of about 1 to about 5 ethylene oxide units, oil, Spanish rosemary oil, coriander oil, thyme oil, pimento and mixtures thereof. berries oil, rose oil, anise oil, balsam oil, bergamot oil, rose d. Silicone Containing Compounds wood oil, cedar oil, chamomile oil, Sage oil, clary sage oil, In non-limiting aspects, silicone containing compounds clove oil, cypress oil, eucalyptus oil, fennel oil, Seafennel oil, include any member of a family of polymeric products whose 35 frankincense oil, geranium oil, ginger oil, grapefruit oil, jas molecular backbone is made up of alternating silicon and mine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, oxygenatoms with side groups attached to the silicon atoms. lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, By varying the -Si-O-chain lengths, side groups, and orange oil, patchouli oil, pepper oil, black pepper oil, petit crosslinking, silicones can be synthesized into a wide variety grain oil, pine oil, rose otto oil, rosemary oil, Sandalwood oil, of materials. They can vary in consistency from liquid to gel 40 spearmint oil, spikenard oil, Vetiver oil, wintergreen oil, or to Solids. ylangylang. Other essential oils known to those of skill in the The silicone containing compounds that can be used in the art are also contemplated as being useful within the context of context of the present invention include those described in the present invention. this specification or those known to a person of ordinary skill f. Thickening Agents in the art. Non-limiting examples include silicone oils (e.g., 45 Thickening agents, including thickener or gelling agents, Volatile and non-volatile oils), gels, and Solids. In certain include Substances which that can increase the viscosity of a aspects, the silicon containing compounds includes a silicone composition. Thickeners includes those that can increase the oils such as a polyorganosiloxane. Non-limiting examples of Viscosity of a composition without Substantially modifying polyorganosiloxanes include dimethicone, cyclomethicone, the efficacy of the active ingredient within the composition. polysilicone-11, phenyl trimethicone, trimethylsilylam 50 Thickeners can also increase the stability of the compositions odimethicone, Stearoxytrimethylsilane, or mixtures of these of the present invention. In certain aspects of the present and other organosiloxane materials in any given ratio in order invention, thickeners include hydrogenated polyisobutene or to achieve the desired consistency and application character trihydroxystearin, or a mixture of both. istics depending upon the intended application (e.g., to a Non-limiting examples of additional thickening agents that particular area such as the skin, hair, or eyes). A “volatile 55 can be used in the context of the present invention include silicone oil includes a silicone oil have a low heat of vapor carboxylic acid polymers, crosslinked polyacrylate poly ization, i.e. normally less than about 50 cal per gram of mers, polyacrylamide polymers, polysaccharides, and gums. silicone oil. Non-limiting examples of volatile silicone oils Examples of carboxylic acid polymers include crosslinked include: cyclomethicones such as Dow Corning 344 Fluid, compounds containing one or more monomers derived from Dow Corning 345 Fluid, Dow Corning 244 Fluid, and Dow 60 acrylic acid, Substituted acrylic acids, and salts and esters of Corning 245 Fluid, Volatile Silicon 7207 (Union Carbide these acrylic acids and the Substituted acrylic acids, wherein Corp., Danbury, Conn.); low viscosity dimethicones, i.e. the crosslinking agent contains two or more carbon-carbon dimethicones having a viscosity of about 50 cst or less (e.g., double bonds and is derived from a polyhydric alcohol (see dimethicones such as Dow Corning 200-0.5 cst Fluid). The U.S. Pat. Nos. 5,087,445; 4,509,949; 2,798,053: CTFA Inter Dow Corning Fluids are available from Dow Corning Corpo 65 national Cosmetic Ingredient Dictionary, Fourth edition, ration, Midland, Mich. Cyclomethicone and dimethicone are 1991, pp. 12 and 80). Examples of commercially available described in the Third Edition of the CTFA Cosmetic Ingre carboxylic acid polymers include carbomers, which are US 8,603,508 B2 15 16 homopolymers of acrylic acid crosslinked with allyl ethers of actives, skin protectant/barrier agents, steroids including hor sucrose or pentaerytritol (e.g., CarbopolTM 900 series from mones and corticosteroids, Sunburn treatment agents, Sun B.F. Goodrich). screens, transdermal actives, nasal actives, vaginal actives, Non-limiting examples of crosslinked polyacrylate poly wart treatment agents, wound treatment agents, wound heal mers include cationic and nonionic polymers. Examples are ing agents, etc. described in U.S. Pat. Nos. 5,100,660; 4,849,484; 4,835,206; I. Kits 4,628,078; 4,599,379). Kits are also contemplated as being used in certain aspects Non-limiting examples of polyacrylamide polymers (in of the present invention. For instance, compositions of the cluding nonionic polyacrylamide polymers including Substi present invention can be included in a kit. A kit can include a tuted branched or unbranched polymers) include polyacryla 10 mide, isoparaffin and laureth-7, multi-block copolymers of container. Containers can include a bottle, a metal tube, a acrylamides and Substituted acrylamides with acrylic acids laminate tube, a plastic tube, a dispenser, a pressurized con and Substituted acrylic acids. tainer, a barrier container, a package, a compartment, a lip Non-limiting examples of polysaccharides include cellu Stick container, a compact container, cosmetic pans that can lose, carboxymethylhydroxyethylcellulose, cellulose acetate 15 hold cosmetic compositions, or other types of containers such propionate carboxylate, hydroxyethylcellulose, hydroxy as injection or blow-molded plastic containers into which the ethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl dispersions or compositions or desired bottles, dispensers, or methylcellulose, methyl hydroxyethylcellulose, microcrys packages are retained. The kit and/or container can include talline cellulose, Sodium cellulose Sulfate, and mixtures indicia on its surface. The indicia, for example, can be a word, thereof. Another example is an alkyl substituted cellulose a phrase, an abbreviation, a picture, or a symbol. where the hydroxy groups of the cellulose polymer is The containers can dispense a pre-determined amount of hydroxyalkylated (preferably hydroxy ethylated or hydrox the composition. In other embodiments, the container can be ypropylated) to form a hydroxyalkylated cellulose which is Squeezed (e.g., metal, laminate, or plastic tube) to dispense a then further modified with a Co-Co straight chain or desired amount of the composition. The composition can be branched chain alkyl group through an ether linkage. Typi 25 dispensed as a spray, an aerosol, a liquid, a fluid, or a semi cally these polymers are ethers of Co-Co straight or Solid. The containers can have spray, pump, or Squeeze branched chain alcohols with hydroxyalkylcelluloses. Other mechanisms. A kit can also include instructions for employ useful polysaccharides include Scleroglucans comprising a ing the kit components as well the use of any other composi linear chain of (1-3) linked glucose units with a (1-6) linked tions included in the container. Instructions can include an glucose every three unit. 30 explanation of how to apply, use, and maintain the composi Non-limiting examples of gums that can be used with the tions. present invention include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium EXAMPLES carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hec 35 The following examples are included to demonstrate cer torite, hyaluroinic acid, hydrated silica, hydroxypropyl chi tain non-limiting aspects of the invention. It should be appre tosan, hydroxypropyl guar, karaya gum, kelp, locust bean ciated by those of skill in the art that the techniques disclosed gum, natto gum, potassium alginate, potassium carrageenan, in the examples which follow represent techniques discov propylene glycol alginate, Sclerotium gum, Sodium car ered by the inventor to function well in the practice of the boyXmethyl dextran, Sodium carrageenan, tragacanth gum, 40 invention. However, those of skill in the art should, in light of Xanthan gum, and mixtures thereof. the present disclosure, appreciate that many changes can be g. Preservatives made in the specific embodiments which are disclosed and Non-limiting examples of preservatives that can be used in still obtain a like or similar result without departing from the the context of the present invention include quaternary spirit and scope of the invention. ammonium preservatives such as polyduaternium-1 and ben 45 Example 1 Zalkonium halides (e.g., benzalkonium chloride (“BAC) and benzalkonium bromide), parabens (e.g., methylparabens and propylparabens), phenoxyethanol, benzyl alcohol, chlorobu Non-Limiting Product Formulation tanol, phenol, Sorbic acid, thimerosal or combinations Non-limiting composition formulated as stable non-ionic thereof. 50 oil-in-water emulsion is described in Table 1. 2. Pharmaceutical Ingredients Pharmaceutical active agents are also contemplated as being useful with the compositions of the present invention. TABLE 1 Non-limiting examples of pharmaceutical active agents Ingredients % (w.fw) 55 include anti-acne agents, agents used to treat rosacea, anal Water 47.6 gesics, anesthetics, anorectals, antihistamines, anti-inflam Homosalate S.O matory agents including non-steroidal anti-inflammatory Octisalate S.O drugs, antibiotics, antifungals, antivirals, antimicrobials, Oxybenzone 4.0 Glycereth-26 4.0 anti-cancer actives, Scabicides, pediculicides, antineoplas Glycerin 2.98S tics, antiperspirants, antipruritics, antipsoriatic agents, anti 60 Avobenzone 2.O Seborrheic agents, biologically active proteins and peptides, Octocrylene 2.O burn treatment agents, cauterizing agents, depigmenting Styrene? Acrylates Copolymer 1.72125 agents, depilatories, diaper rash treatment agents, enzymes, Betaine 1.O Glyceryl Stearate O.9 hair growth stimulants, hair growth retardants including Arachidyl Alcohol O.6OS DFMO and its salts and analogs, hemostatics, kerotolytics, 65 PEG-100 Stearate O.6 canker Sore treatment agents, cold Sore treatment agents, Arachidyl Glucoside O.16S dental and periodontal treatment agents, photosensitizing US 8,603,508 B2 18 TABLE 1-continued Example 5 Ingredients % (w.fw) Prophetic Examples Panthenol O.1 Allantoin O.08 5 Additional efficacy data points of compositions of the Excipients' C.S. present inventions can be determined by methods known to TOTAL 1OO those of ordinary skill in the art. The following are non *Cosmetic or pharmaceutical excipients can be used to fill out the composition to create a limiting procedures that can be used in the context of the desired product (e.g., cream, lotion, etc.), tactile property (e.g., non-oily feel, lightweight, silky, etc.), viscosity (e.g., thicker or thinner formulation), and or a therapeutic effect (e.g., present invention. It should be recognized that other testing treatment offine lines and wrinkles, skin-whitening, evening skintone, increased collagen 10 procedures can be used, including, for example, objective and production, etc.). Non-limiting examples of such excipients that can be used with the Table 1 formulation are known to those having skill in the cosmetic and pharmaceutical field Subjective procedures. including those disclosed in the present specification (e.g., moisturizing agents, antioxi dants, structuring agents, essential and non-essential oils, thickening agents, preservatives, Skin moisture/hydration can be measured by using imped skin lightening agents, silicone containing compounds, vitamins, minerals, pharmaceutical ance measurements with the Nova Dermal Phase Meter. The ingredients, fragrances, colors, dyes, chelating agents, botanical extracts, anti-microbial agents, anti-irritants, pH adjusters, exfoliants, etc.), impedance meter measures changes in skin moisture content. 15 The outer layer of the skin has distinct electrical properties. The above formulation has less than 50% by weight of When skin is dry it conducts electricity very poorly. As it water and yet remains stable and provides an SPF protection becomes more hydrated increasing conductivity results. Con to a user of approximately 30. This formulation includes: (a) sequently, changes in skin impedance (related to conductiv a combination of non-ionic emulsifiers (i.e., glyceryl Stearate, ity) can be used to assess changes in skin hydration. The unit PEG-100 stearate, and arachidyl glucoside) and non-ionic can be calibrated according to instrument instructions for emulsion stabilizers (e.g., arachidyl alcohol); (b) a combina each testing day. A notation of temperature and relative tion of humectant skin conditioning agents (i.e., glycereth-26, humidity can also be made. Subjects can be evaluated as glycerin, betaine, panthenol, and allantoin); and a combina follows: prior to measurement they can equilibrate in a room tion of UV absorbing agents (i.e., homosalate, octisalate, with defined humidity (e.g., 30-50%) and temperature (e.g., oxybenzone, avobenzone, octocrylene, and styrenefacrylates 25 68-72C). Three separate impedance readings can be taken on copolymer). The ratio of the total amount of water (w/w) to each side of the face, recorded, and averaged. The T5 setting the total amount of the combination non-ionic emulsifiers and can be used on the impedance meter which averages the non-ionic emulsion stabilizers (w/w) is approximately 21:1; impedance values of every five seconds application to the the ratio of the total amount of water (w/w) to the total amount face. Changes can be reported with statistical variance and of the combination of humectant skin conditioning agents 30 significance. (w/w) is approximately 6:1; the ratio of the total amount of Skin clarity and the reduction in freckles and age spots can water (W/w) to the total amount of the combination of UV be evaluated using a Minolta Chromometer. Changes in skin absorbing agents (w/w) is approximately 2.4:1. These ratios color can be assessed to determine irritation potential due to produce a stable emulsion that is effective in moisturizing product treatment using the a values of the Minolta Chroma skin (see below data) while also having aesthetically pleasing 35 Meter. Thea value measures changes in skin color in the red tactile properties. region. This is used to determine whether a composition is The compositions in Table 1 was prepared by mixing the inducing irritation. The measurements can be made on each hydrophilic and hydrophobic ingredients in separate contain side of the face and averaged, as left and right facial values. ers at room temperature (20-25°C.). The containers were then Skin clarity can also be measured using the Minolta Meter. added together with continuous mixing under heat (approxi 40 The measurement is a combination of the a, b, and L values mately 60-80°C.) until a homogenous mixture was obtained. of the Minolta Meter and is related to skin brightness, and The mixture was then cooled to room temperature (approxi correlates well with skin smoothness and hydration. Skin mately 20-25° C.). reading is taken as above. In one non-limiting aspect, skin Example 2 clarity can be described as L/C where C is chroma and is 45 defined as (a+b)'. Skin dryness, Surface fine lines, skin Smoothness, and skin Skin Moisturization Data tone can be evaluated with clinical grading techniques. For The Table 1 composition was tested for its ability to mois example, clinical grading of skin dryness can be determined turize human skin. Although data is not shown, the composi by a five point standard Kligman Scale: (0) skin is soft and 50 moist; (1) skin appears normal with no visible dryness; (2) tion moisturized human skin. skin feels slightly dry to the touch with no visible flaking; (3) Example 3 skin feels dry, tough, and has a whitish appearance with some Scaling; and (4) skin feels very dry, rough, and has a whitish UV Data appearance with Scaling. Evaluations can be made indepen 55 dently by two clinicians and averaged. The Table 1 composition was tested for its ability to absorb Clinical grading of skin tone can be performed via a ten ultra violet radiation. Although data is not shown, the com point analog numerical scale: (10) even skin of uniform, position exhibited ultra violet absorption characteristics con pinkish brown color. No dark, erythremic, or scaly patches sisting with a rating of a Sun Protection Factor (SPF) of at upon examination with a hand held magnifying lens. Micro least 30. 60 texture of the skin very uniform upon touch; (7) even skin tone observed without magnification. No scaly areas, but Example 4 slight discolorations either due to pigmentation or erythema. No discolorations more than 1 cm in diameter; (4) both skin Stability Data discoloration and uneven texture easily noticeable. Slight 65 Scaliness. Skin rough to the touch in Some areas; and (1) The Table 1 composition was confirmed to be stable under uneven skin coloration and texture. Numerous areas of scali a heat stability test. ness and discoloration, either hypopigmented, erythremic or US 8,603,508 B2 19 20 dark spots. Large areas of uneven color more than 1 cm in ment should be standardized prior to each use by scanning diameter. Evaluations were made independently by two cli metal standards of know values. RaValue can be computed by nicians and averaged. the following equation: R. Standardize roughness; 1, the Clinical grading of skin Smoothness can be analyzed via a traverse (scan) length; and y=the absolute value of the loca ten point analog numerical scale: (10) Smooth, skin is moist 5 tion of the profile relative to the mean profile height (X-axis). and glistening, no resistance upon dragging finger across In other non-limiting aspects, the efficacy of the composi Surface; (7) Somewhat Smooth, slight resistance; (4) rough, tions of the present invention can be evaluated by using a skin visibly altered, friction upon rubbing; and (1) rough, flaky, analog, such as, for example, MELANODERMTM. Melano uneven surface. Evaluations were made independently by two cytes, one of the cells in the skin analog, stain positively when clinicians and averaged. 10 exposed to L-dihydroxyphenylalanine (L-DOPA), a precur Skin Smoothness and wrinkle reduction can also be sor of melanin. The skin analog, MELANODERMTM, can be assessed visually by using the methods disclosed in Packman treated with a variety of bases containing the compositions et al. (1978). For example, at each subject visit, the depth, and whitening agents of the present invention or with the base shallowness and the total number of superficial facial lines alone as a control. Alternatively, an untreated sample of the (SFLs) of each subject can be carefully scored and recorded. 15 skin analog can be used as a control. This test can also be used A numerical score was obtained by multiplying a number to confirm the skin exfoliation abilities of the composition factor times a depth/width/length factor. Scores are obtained (e.g., stain skin and then treat stained skin with composition for the eye area and mouth area (left and right sides) and to determine amount of stain removed over a targeted time added together as the total wrinkle score. period). Skin firmness can be measured using a Hargens ballistom Skin clarity and the reduction in freckles and age spots can eter, a device that evaluates the elasticity and firmness of the be evaluated using a Minolta Chromometer. Changes in skin skin by dropping a small body onto the skin and recording its color can be assessed to determine irritation potential due to first two rebound peaks. The ballistometry is a small light product treatment using the a values of the Minolta Chroma weight probe with a relatively blunt tip (4 Square mm-contact Meter. Thea value measures changes in skin color in the red area) was used. The probe penetrates slightly into the skin and 25 region. This is used to determine whether the product is results in measurements that are dependent upon the proper inducing irritation. The measurements were made on each ties of the outer layers of the skin, including the stratum side of the face and averaged, as left and right facial values. corneum and outer epidermis and some of the dermal layers. Skin clarity can also be measured using the Minolta Meter. Skin softness/suppleness can be evaluated using the Gas The measurement is a combination of the a, b, and L values Bearing Electrodynamometer, an instrument that measures 30 of the Minolta Meter and is related to skin brightness, and the stress/strain properties of the skin. The viscoelastic prop correlates well with skin smoothness and hydration. Skin erties of skin correlate with skin moisturization. Measure reading is taken as above. Skin clarity is defined as L/C where ments can be obtained on the predetermined site on the cheek C is chroma and is defined as (a+b)'. area by attaching the probe to the skin surface with double All of the compositions and/or methods disclosed and Stick tape. A force of approximately 3.5gm can be applied 35 claimed in this specification can be made and executed with parallel to the skin Surface and the skin displacement is accu out undue experimentation in light of the present disclosure. rately measured. Skin Suppleness can then be calculated and While the compositions and methods of this invention have is expressed as DSR (Dynamic Spring Rate in gm/mm). been described in terms of particular embodiments, it will be The appearance of lines and wrinkles on the skin can be apparent to those of skill in the art that variations may be evaluated using replicas, which is the impression of the skin's 40 applied to the compositions and/or methods and in the steps or surface. Silicone rubber like material can be used. The replica in the sequence of steps of the method described herein with can be analyzed by image analysis. Changes in the visibility out departing from the concept, spirit and scope of the inven of lines and wrinkles can be objectively quantified via the tion. More specifically, it will be apparent that certain agents taking of silicon replicas form the Subjects face and analyZ which are both chemically and physiologically related may ing the replicas image using a computer image analysis sys 45 be substituted for the agents described herein while the same tem. Replicas can be taken from the eye area and the neck or similar results would be achieved. All such similar substi area, and photographed with a digital camera using a low tutes and modifications apparent to those skilled in the art are angle incidence lighting. The digital images can be analyzed deemed to be within the spirit, scope and concept of the with an image processing program and the are of the replicas invention as defined by the appended claims. covered by wrinkles or fine lines was determined. 50 The invention claimed is: The Surface contour of the skin can be measured by using 1. An oil-in-water emulsion comprising about 2-3% w/w of the profilometer/Stylus method. This includes either shining a combination of a light or dragging a stylus across the replica Surface. The glyceryl Stearate; Vertical displacement of the stylus can be fed into a computer arachidyl alcohol: via a distance transducer, and after scanning a fixed length of 55 PEG-100 stearate; and replica a cross-sectional analysis of skin profile can be gen arachidylglucoside, erated as a two-dimensional curve. This scan can be repeated wherein the emulsion comprises less than 50% w/w of any number of times along a fix axis to generate a simulated Water. 3-D picture of the skin. Ten random sections of the replicas 2. The oil-in-water emulsion of claim 1, comprising: using the stylus technique can be obtained and combined to 60 about 0.8 to 1% w/w of glyceryl Stearate; generate average values. The values of interest include Ra about 0.5 to 0.7% w/w of arachidyl alcohol: which is the arithmetic mean of all roughness (height) values about 0.5 to 0.7% w/w of PEG-100 stearate; and computed by integrating the profile height relative to the about 0.1 to 0.3% w/w of arachidylglucoside. mean profile height. Rt which is the maximum vertical dis 3. The oil-in-water emulsion of claim 1, comprising about tance between the highest peak and lowest trough, and RZ 65 40 to less than 50% w/w of water. which is the mean peak amplitude minus the mean peak 4. The oil-in-water emulsion of claim 1, further comprising height. Values are given as a calibrated value in mm. Equip a skin conditioning agent and a UV absorbing agent. US 8,603,508 B2 21 22 5. The oil-in-water emulsion of claim 4, wherein the skin conditioning agent is glycereth-26, glycerin, betaine, pan thenol, or allantoin. 6. The oil-in-water emulsion of claim 4, wherein the UV absorbing agent include is homosalate, octisalate, oxyben- 5 Zone, avobenzone, octocrylene, or styrenefacrylates copoly C. UNITED STATES PATENT AND TRADEMARK OFFICE CERTIFICATE OF CORRECTION PATENT NO. : 8,603,508 B2 Page 1 of 1 APPLICATIONNO. : 13/730172 DATED : December 10, 2013 INVENTOR(S) : Greg Norman It is certified that error appears in the above-identified patent and that said Letters Patent is hereby corrected as shown below:

In the Claims

In claim 6 on column 21, line 5, delete “include.

Signed and Sealed this Eighth Day of April, 2014 74-4-04- 2% 4 Michelle K. Lee Deputy Director of the United States Patent and Trademark Office