WATER SYSTEM DISINFECTION Components
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Chemical Disinfectants for Biohazardous Materials (3/21)
Safe Operating Procedure (Revised 3/21) CHEMICAL DISINFECTANTS FOR BIOHAZARDOUS MATERIALS ____________________________________________________________________________ Chemicals used for biohazardous decontamination are called sterilizers, disinfectants, sanitizers, antiseptics and germicides. These terms are sometimes equivalent, but not always, but for the purposes of this document all the chemicals described herein are disinfectants. The efficacy of every disinfectant is based on several factors: 1) organic load (the amount of dirt and other contaminants on the surface), 2) microbial load, 3) type of organism, 4) condition of surfaces to be disinfected (i.e., porous or nonporous), and 5) disinfectant concentration, pH, temperature, contact time and environmental humidity. These factors determine if the disinfectant is considered a high, intermediate or low-level disinfectant, in that order. Prior to selecting a specific disinfectant, consider the relative resistance of microorganisms. The following table provides information regarding chemical disinfectant resistance of various biological agents. Microbial Resistance to Chemical Disinfectants: Type of Microbe Examples Resistant Bovine spongiform encephalopathy (Mad Prions Cow) Creutzfeldt-Jakob disease Bacillus subtilis; Clostridium sporogenes, Bacterial Spores Clostridioides difficile Mycobacterium bovis, M. terrae, and other Mycobacteria Nontuberculous mycobacterium Poliovirus; Coxsackievirus; Rhinovirus; Non-enveloped or Small Viruses Adenovirus Trichophyton spp.; Cryptococcus sp.; -
Decontamination of Rooms, Medical Equipment and Ambulances Using an Aerosol of Hydrogen Peroxide Disinfectant B.M
Journal of Hospital Infection (2006) 62, 149–155 www.elsevierhealth.com/journals/jhin Decontamination of rooms, medical equipment and ambulances using an aerosol of hydrogen peroxide disinfectant B.M. Andersena,*, M. Rascha, K. Hochlina, F.-H. Jensenb, P. Wismarc, J.-E. Fredriksend aDepartment of Hospital Infection, Ulleva˚l University Hospital, Oslo, Norway bDivision of Pre-hospital Care, Ulleva˚l University Hospital, Oslo, Norway cDepartment of Medical Equipment, Ulleva˚l University Hospital, Oslo, Norway dHealth and Environment AS, Oslo, Norway Received 17 November 2004; accepted 1 July 2005 KEYWORDS Summary A programmable device (Sterinis, Gloster Sante Europe) Room decontamina- providing a dry fume of 5% hydrogen peroxide (H2O2) disinfectant was tion; Ambulance tested for decontamination of rooms, ambulances and different types of decontamination; medical equipment. Pre-set concentrations were used according to the Medical equipment decontamination; volumes of the rooms and garages. Three cycles were performed with Hydrogen peroxide increasing contact times. Repetitive experiments were performed using fume decontamina- Bacillus atrophaeus (formerly Bacillus subtilis) Raven 1162282 spores to tion; Spore test control the effect of decontamination; after a sampling plan, spore strips were placed in various positions in rooms, ambulances, and inside and outside the items of medical equipment. Decontamination was effective in 87% of 146 spore tests in closed test rooms and in 100% of 48 tests in a surgical department when using three cycles. One or two cycles had no effect. The sporicidal effect on internal parts of the medical equipment was only 62.3% (220 tests). When the devices were run and ventilated during decontamination, 100% (57/57) of spore strips placed inside were decontaminated. -
Billing Code: 3510-Ds-P Department Of
This document is scheduled to be published in the Federal Register on 01/30/2015 and available online at http://federalregister.gov/a/2015-01795, and on FDsys.gov BILLING CODE: 3510-DS-P DEPARTMENT OF COMMERCE International Trade Administration C-570-009 Calcium Hypochlorite from the People’s Republic of China: Countervailing Duty Order AGENCY: Enforcement and Compliance, International Trade Administration, Department of Commerce SUMMARY: Based on affirmative final determinations by the Department of Commerce (“Department”) and the International Trade Commission (“ITC”), the Department is issuing a countervailing duty order on calcium hypochlorite from the People’s Republic of China (“PRC”). EFFECTIVE DATE: [(Insert date of publication in the Federal Register]. FOR FURTHER INFORMATION CONTACT: Katie Marksberry, AD/CVD Operations, Office V, Enforcement and Compliance, International Trade Administration, U.S. Department of Commerce, 14th Street and Constitution Avenue, NW, Washington, DC 20230; telephone: (202) 482-7906. SUPPLEMENTARY INFORMATION: Background In accordance with section 705(d) of the Tariff Act of 1930, as amended (“the Act”), on December 15, 2014, the Department published its final determination that countervailable subsidies are being provided to producers and exporters of calcium hypochlorite from the PRC.1 On January 21, 2015, the ITC notified the Department of its final determination pursuant to 1 See Calcium Hypochlorite from the People’s Republic of China: Final Affirmative Countervailing Duty Determination; 79 FR -
THE JOURNAL of INDUSTRIAL and ENGINEERING CHEMISTRY 953 with Stirring, and the Flask Allowed to Stand
OCt., 1917 THE JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY 953 with stirring, and the flask allowed to stand. The ascertaining the presence of aniline, the calcium hypo- solution, when the precipitate has settled, is filtered chlorite test is employed. The quantitative deter- through a Gooch crucible, using a bell jar arrangement, mination is carried out by precipitating the aniline into a 250 to 300 cc. Erlenmeyer flask. The crucible as tribromoaniline with bromine water. The precipi- is fitted preferably with a small circular filter paper tate is caught on a tared filter paper, dried in vacuo, (cut to size) instead of asbestos. The flask should be and weighed. washed with wash-ether (100parts absolute ether and In this connection, it occurred to the writer that it 2 parts alcoholic HC1) while filtering so as not to allow might be possible to work out, for estimating the any ferric chloride to dry on the white precipitate or aniline, a colorimetric method based on the qualita- on the crucible. The usual precautions of washing the tive test with hypochlorite. If this were possible, flask, crucible and funnel are taken to insure complete it certainly would be desirable, for not only would transfer of iron. It is not necessary, however, to trans- considerable time and effort be saved but probably fer all of the aluminum chloride precipitate to the a considerably smaller sample than IO liters would be Gooch crucible. The aluminum precipitate is removed sufficient and quantitative measurements could also with the paper from the crucible by tapping it into a be applied in cases where the amount of aniline in 25 cc. -
Evaluating Disinfectants for Use Against the COVID-19 Virus
When it comes to choosing a disinfectant to combat the COVID-19 virus, research and health authorities suggest not all disinfectants are equally effective. The difference is in their active ingredient(s). HEALTH CANADA AND U.S. EPA ASSESSMENTS The work to evaluate disinfectants perhaps best starts with lists of approved disinfectants compiled by government health authorities. Health Canada has compiled a list of 85 hard surface disinfectant products (as of March 20, 2020) that meet their requirements for disinfection of emerging pathogens, including the virus that causes COVID-19. It can be accessed here. You can wade through the entire list. But if you locate the Drug Identification Number (DIN) on the disinfectant product label or the safety data sheet (SDS), then you can use the search function to quickly see if the product meets Health Canada requirements. A second list, updated on March 19, 2020, provides 287 products that meet the U.S. Environmental Protection Agency’s (EPA) criteria for use against SARS-CoV-2, the novel coronavirus that causes the disease COVID-19. This list can be found here. Like the Health Canada list, you can wade through this one too. However, to best use this list, you should locate the U.S. EPA registration number on the product label or SDS, and use that number to search the list. The U.S. EPA registration number of a product consists of two sets of numbers separated by a hyphen. The first set of numbers refers to the company identification number, and the second set of numbers following the hyphen represents the product number. -
Chloroform 18.08.2020.Pdf
Chloroform Chloroform, or trichloromethane, is an organic compound with formula CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on a large scale as a precursor to PTFE. It is also a precursor to various refrigerants. It is one of the four chloromethanes and a trihalomethane. It is a powerful anesthetic, euphoriant, anxiolytic and sedative when inhaled or ingested. Formula: CHCl₃ IUPAC ID: Trichloromethane Molar mass: 119.38 g/mol Boiling point: 61.2 °C Density: 1.49 g/cm³ Melting point: -63.5 °C The molecule adopts a tetrahedral molecular geometry with C3v symmetry. Chloroform volatilizes readily from soil and surface water and undergoes degradation in air to produce phosgene, dichloromethane, formyl chloride, carbon monoxide, carbon dioxide, and hydrogen chloride. Its half-life in air ranges from 55 to 620 days. Biodegradation in water and soil is slow. Chloroform does not significantly bioaccumulate in aquatic organisms. Production:- In industry production, chloroform is produced by heating a mixture of chlorine and either chloromethane (CH3Cl) or methane (CH4). At 400–500 °C, a free radical halogenation occurs, converting these precursors to progressively more chlorinated compounds: CH4 + Cl2 → CH3Cl + HCl CH3Cl + Cl2 → CH2Cl2 + HCl CH2Cl2 + Cl2 → CHCl3 + HCl Chloroform undergoes further chlorination to yield carbon tetrachloride (CCl4): CHCl3 + Cl2 → CCl4 + HCl The output of this process is a mixture of the four chloromethanes (chloromethane, dichloromethane, chloroform, and carbon tetrachloride), which can then be separated by distillation. Chloroform may also be produced on a small scale via the haloform reaction between acetone and sodium hypochlorite: 3 NaClO + (CH3)2CO → CHCl3 + 2 NaOH + CH3COONa Deuterochloroform[ Deuterated chloroform is an isotopologue of chloroform with a single deuterium atom. -
Safer Disinfectant Use in Child Care and Schools During the COVID-19 Pandemic
Safer Disinfectant Use in Child Care and Schools During the COVID-19 Pandemic Vickie Leonard, PhD Environmental Health in Early Care and Educaon Project, Western States Pediatric Environmental Health Specialty Unit (WSPEHSU) 1 Why Should We Be Concerned about Environmental Health in ECE? 2 Why Should We Be Concerned about Environmental Health in ECE? • There are 8 million children in child care centers in the U.S. A child may spend up to 12,500 hours in an ECE facility. A million child care providers work in these centers in the U.S. Half are child-bearing age. • Many toxicants found in child care facilities are not addressed in state child care health and safety regulations. • No agency at the state or federal level is charged with ensuring children’s health and safety in and around schools and ECE facilities. • No systematic means exists for collecting data on environmental exposures in these buildings. • Teachers have more protection in these buildings (unions, OSHA) than children do 3 Why Should We Be Concerned about Environmental Health in ECE? • Many people think that adults and children are exposed to, and affected by, toxic chemicals in the same way. • This is not the case. • Children • have higher exposures to toxicants in the environment, • are more vulnerable to the effects of those toxicants than adults. 4 Cleaning and Disinfec?ng Products: A Major Source of Exposure in Child Care and Schools • Products used to clean, sanitize and disinfect child care facilities and schools are a good example of the pervasive and unregulated use of toxic chemicals that put the health of our children at risk. -
Mechanism of Action of Sodium Hypochlorite ISSN 0103-6440113
Braz Dent J (2002) 13(2): 113-117 Mechanism of action of sodium hypochlorite ISSN 0103-6440113 Mechanism of Action of Sodium Hypochlorite Carlos ESTRELA1 Cyntia R.A. ESTRELA1 Eduardo Luis BARBIN2 Júlio César E. SPANÓ2 Melissa A. MARCHESAN2 Jesus D. PÉCORA2 1Faculty of Dentistry, Federal University of Goiás, Goiânia, GO, Brazil 2Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil The choice of an irrigating solution for use in infected root canals requires previous knowledge of the microorganisms responsible for the infectious process as well as the properties of different irrigating solutions. Complex internal anatomy, host defenses and microorganism virulence are important factors in the treatment of teeth with asymptomatic apical periodontitis. Irrigating solutions must have expressive antimicrobial action and tissue dissolution capacity. Sodium hypochlorite is the most used irrigating solution in endodontics, because its mechanism of action causes biosynthetic alterations in cellular metabolism and phospholipid destruction, formation of chloramines that interfere in cellular metabolism, oxidative action with irreversible enzymatic inactivation in bacteria, and lipid and fatty acid degradation. The aim of this work is to discuss the mechanism of action of sodium hypochlorite based on its antimicrobial and physico-chemical properties. Key Words: sodium hypochlorite, irrigating solution, intracanal dressing. INTRODUCTION microbial agent to the infected site, adequate concen- tration of the agent, -
Disinfection Session Objectives
Disinfection Session Objectives • To introduce the principal disinfectants that may be used and highlight key advantages and disadvantages of each • To emphasise the use of chlorination for routine disinfection. • To describe the process of chlorination and discuss the concepts of breakpoint chlorination, chlorine demand and outline basic chlorine chemistry. • To discuss the types of chlorine available and how these may be used for routine disinfection. WHO SEMINAR PACK FOR DRINKING-WATER QUALITY Disinfection Introduction All water supplies should be disinfected. This is aimed both at inactivating remaining bacteria before distribution and providing a residual disinfectant to inactivate bacteria introduced by any subsequent ingress of contaminated water during storage or distribution. At present, the principal disinfectant used worldwide is chlorine, although alternatives are being increasingly investigated and process such as ozonation are becoming more common. Chlorine is generally the disinfectant of choice as it is reasonably efficient, cheap and easy to handle. In all but the smallest water treatment plants, chlorine is added to water as either in aqueous solution (calcium hypochlorite or sodium hypochlorite) or chlorine gas. Smaller supplies may use tablets of hypochlorite. Other disinfectants include ozone, ultraviolet light and iodine. These all have disadvantages. UV is not a particularly effective disinfectant and it is difficult to expose water for sufficient time for disinfection to be effective. Neither ozone or UV provide a residual disinfectant and therefore offer no protection against recontamination in distribution. To overcome this, in some water supplies booster ozonation stations are set up along the distribution network. Both iodine and ozone are carcinogenic. There are also significant health and safety concerns, for operators, regarding the generation and application of ozone and chlorine (especially in the gaseous form). -
Silver As a Drinking-Water Disinfectant
Silver as a drinking-water disinfectant Silver as a drinking-water disinfectant Alternative drinking-water disinfectants: silver ISBN 978-92-4-151369-2 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution- NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. Alternative drinking-water disinfectants: bromine, iodine and silver. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris. Sales, rights and licensing. To purchase WHO publications, see http://apps.who.int/bookorders. -
CHEMICAL STORAGE SEGREGATION GUIDELINES Incompatible Chemicals Should Always Be Handled and Stored So That They Do Not Accidentally Come in Contact with Each Other
Laboratory Safety Reminders January 2007 ♦ Mount Holyoke College – Environmental Health and Safety CHEMICAL STORAGE SEGREGATION GUIDELINES Incompatible chemicals should always be handled and stored so that they do not accidentally come in contact with each other. This list is not complete, nor are all compatibilities shown. These materials can react to produce excessive heat, harmful vapors, and/or other deadly reactions. Always know the hazards and incompatibilities of a chemical before using it. Chemicals Avoid Accidental Contact With Acetic acid Chromic acid, nitric acid, permanganates, peroxides Hydroxyl-containing compounds such as perchloric acid, Acetic anhydride ethylene glycol Concentrated nitric acid and sulfuric acid mixtures, peroxides (i.e. Acetone peracetic acid solution, hydrogen peroxide) Acetylene Chlorine, bromine, copper, silver, fluorine, mercury Alkali, alkaline earth and strongly electropositive metals (powered Carbon dioxide, carbon tetrachloride and other chlorinated aluminum, magnesium, sodium, hydrocarbons potassium) Mercury, chlorine, calcium hypochlorite, iodine, bromine, hydrogen Ammonia (anhydrous) fluoride Acids, metal powders, flammable liquids, chlorates, nitrates, sulfur, Ammonium nitrate finely divided organics, combustibles Aniline Nitric acid, hydrogen peroxide Arsenical compounds Any reducing agent Azides Acids Ammonia, acetylene, butadiene, butane, other petroleum gases, Bromine sodium carbide, turpentine, benzene, finely divided metals Calcium oxide Water Carbon activated Calcium hypochlorite, other -
Infection Prevention & Control Chlorhexidine
Winnipeg Regional Health Authority Acute Care Infection Prevention & Control Manual INFECTION PREVENTION & CONTROL CHLORHEXIDINE GLUCONATE CONCENTRATION FOR HAND HYGIENE COMMUNICATION FORM PART 1: ISSUE & RECOMMENDATIONS Issue: The WRHA Infection Prevention and Control program (IP&C) was requested to research and recommend acceptable concentrations of chlorhexidine gluconate (CHG) (2% versus 4%) for hand hygiene in all programs within WRHA sites, to ensure appropriate products are being used, and facilitate standardization. Recommendations: Use 2% CHG hand cleansers for hand hygiene when antimicrobial hand soap is indicated. Do NOT use 4% CHG for hand hygiene as the minimal improvement in efficacy (from 2%), does not warrant the increased frequency of skin irritation and breakdown, which ultimately impedes effective hand hygiene practices. PART 2: BACKGROUND: DISCUSSION OF ISSUE, OPTIONS AND ANALYSIS & REFERENCES Discussion of Issue: There are several different hand hygiene products used within and between WRHA sites. All areas should adhere to recommended hand hygiene products, as determined by available evidence. There are differences in when specific hand hygiene products are indicated. It is important to identify the appropriate product to use for the appropriate reason, as supported by evidence. Options and Analysis: 1. CHG has a cumulative effect when applied to the skin. In hand hygiene, this effect remains and is sustained, especially when hand hygiene is repeated. 2% CHG is appropriate for hand antisepsis because of the cumulative effect.1 2. Literature regarding differences between 2% and 4% CHG identifies there is minimal difference in efficacy between 2% and 4% CHG for hand antisepsis and cleansing.2 3. The frequency of skin irritation is concentration dependent, with products containing 4% most likely to cause dermatitis when used frequently for hand antisepsis.