Transgender Identity and Cryptorchidism: a Case Study
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Clinical, Hormonal and Genetic Characteristics of Androgen Insensitivity Syndrome in 39 Chinese Patients Qingxu Liu, Xiaoqin Yin and Pin Li*
Liu et al. Reproductive Biology and Endocrinology (2020) 18:34 https://doi.org/10.1186/s12958-020-00593-0 RESEARCH Open Access Clinical, hormonal and genetic characteristics of androgen insensitivity syndrome in 39 Chinese patients Qingxu Liu, Xiaoqin Yin and Pin Li* Abstract Background: Abnormal androgen receptor (AR) genes can cause androgen insensitivity syndrome (AIS), and AIS can be classified into complete androgen insensitivity syndrome (CAIS), partial androgen insensitivity syndrome (PAIS) and mild AIS. We investigated the characteristics of clinical manifestations, serum sex hormone levels and AR gene mutations of 39 AIS patients, which provided deeper insight into this disease. Methods: We prospectively evaluated 39 patients with 46, XY disorders of sex development (46, XY DSD) who were diagnosed with AIS at the Department of Endocrinology of Shanghai Children’s Hospital from 2014 to 2019. We analysed clinical data from the patients including hormone levels and AR gene sequences. Furthermore, we screened the AR gene sequences of the 39 AIS patients to identify probable mutations. Results: The 39 AIS patients came from 37 different families; 19 of the patients presented CAIS, and 20 of them presented PAIS. The CAIS patients exhibited a higher cryptorchidism rate than the PAIS (100 and 55%, P = 0.001). There were no significant difference between the CAIS and PAIS groups regarding the levels of inhibin B (INHB), sex hormone-binding globulin (SHBG), basal luteinizing hormone (LH), testosterone (T), or basal dihydrotestosterone (DHT), the T:DHT ratio, DHT levels after human chorionic gonadotropin (HCG) stimulation or T levels after HCG stimulation. However, the hormone levels of AMH (P = 0.010), peak LH (P = 0.033), basal FSH (P = 0.009) and peak FSH (P = 0.033) showed significant differences between the CAIS group and the PAIS group. -
LGBTQ Notion Evaluation: a Bibliometric Analysis and Systematic Review
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Library Philosophy and Practice (e-journal) Libraries at University of Nebraska-Lincoln Summer 6-15-2021 LGBTQ Notion Evaluation: A Bibliometric Analysis and Systematic Review Poonam Gautam University School of Management, Kurukshetra University, Kurukshetra, HARYANA INDIA, [email protected] Dr. Ajay Solkhe University School of Management, Kurukshetra University, Kurukshetra, HARYANA INDIA, [email protected] Follow this and additional works at: https://digitalcommons.unl.edu/libphilprac Part of the Business Administration, Management, and Operations Commons, Human Resources Management Commons, Lesbian, Gay, Bisexual, and Transgender Studies Commons, Organizational Behavior and Theory Commons, and the Other Feminist, Gender, and Sexuality Studies Commons Gautam, Poonam and Solkhe, Dr. Ajay, "LGBTQ Notion Evaluation: A Bibliometric Analysis and Systematic Review" (2021). Library Philosophy and Practice (e-journal). 5886. https://digitalcommons.unl.edu/libphilprac/5886 1 LGBTQ Notion Evaluation: A Bibliometric Analysis and Systematic Review Poonam (Main Author) Junior Research Fellow University School of Management, Kurukshetra University, Kurukshetra-136118, Haryana, INDIA [email protected] Dr. Ajay Solkhe, (Corresponding Author) Sr. Assistant Professor University School of Management, Kurukshetra University, Kurukshetra-136118, Haryana, INDIA [email protected] Mobile: 9896544852 Abstract Several conservative sectors and employers are embracing equality objectives, including financial institutions, for example, more importantly, there has been a change in attitude and support towards the LGBT+ issues, which has been noticed in other professions and companies, including law and accountancy. The LGBT group includes Lesbians, Gay, Bisexuals and Transgender sexual orientation. Gay men and heterosexuals have also been observed to be in these groups. -
Multiple Congenital Genitourinary Anomalies in a Polled Goat
Multiple Congenital Genitourinary Anomalies in a Polled Goat WILLIAM W. KING, DVM, PHD, DIPLOMATE, ACLAM,1,2* MELVIN E. YOUNG,1 AND M. EUGENE FOX, DVM3 A 1-day-old, Toggenburg/Nubian crossbred goat of polled parentage was referred for necropsy because of a large (diameter, 5 cm) bladder-like mass protruding from the perineal midline and difficult urination. Differential diagnoses included cutaneous cyst, ectopic urinary bladder, and urethral diverticulum/dilatation. Several genitourinary aberrations were noted. A second, smaller (diameter, 1 cm), more distal cystic structure was adjacent to an ambiguous prepuce. Testicles were discovered within a con- stricted, subcutaneous space near the inguinal canals. A rudimentary penis was located dorsal to the penile urethra with no appreciable urethral process. A tiny external urethral orifice was discerned only after liquid was injected into the lumen of the cystic structures, confirming their identity as urethral dilatations. The dilatations were separated by a constricting band of fibrous tissue. No other significant findings were detected. This case illustrates a combination of congenital anomalies including bilateral cryptorchidism with scrotal absence, segmental urethral hypoplasia, and urethral dilatation, most likely associated with the intersex condition seen in polled breeds. The continued production and use of small ruminants as animal models demands the prompt recognition of congenital anomalies. This case also exemplifies the precautions required when breeding goats with polled ancestry. The domestic goat (Capra hircus) has historically served and Nubian/Toggenburg sire. The owner reported that the doe had continues to play an important role in biomedical research (1). completed a normal gestation period on a diet of natural grass/ Many small breeds are available, facilitating common labora- alfalfa hay and water. -
© 2013 Daniela Jauk All Rights Reserved Global Gender Policy Development in the Un: a Sociological
© 2013 DANIELA JAUK ALL RIGHTS RESERVED GLOBAL GENDER POLICY DEVELOPMENT IN THE UN: A SOCIOLOGICAL EXPLORATION OF THE POLITICS, PROCESSES, AND LANGUAGE A Dissertation Presented to The Graduate Faculty of The University of Akron In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy Daniela Jauk August, 2013 GLOBAL GENDER POLICY DEVELOPMENT IN THE UN: A SOCIOLOGICAL EXPLORATION OF THE POLITICS, PROCESSES, AND LANGUAGE Daniela Jauk Dissertation Approved: Accepted: ________________________ ________________________ Advisor Department Chair Dr. Kathryn Feltey Dr. Matthew Lee ________________________ _______________________ Committee Member Dean of the College Dr. Matthew Lee Dr. Chand Midha ________________________ ________________________ Committee Member Dean of the Graduate School Dr. Sandra Spickard Prettyman Dr. George R. Newkome ________________________ ________________________ Committee Member Date Dr. Clare Stacey ________________________ Committee Member Dr. Sarah Swider ________________________ Committee Member Dr. Robert Peralta ii ABSTRACT The United Nations (UN) provided a stage for the evolution of a global women’s movement and global gender equality policy in the 20th century. My dissertation adds a unique perspective to the sociological literature on the global gender equality regime in that it focuses on the social construction of gender equality policy in the Commission on the Status of Women (CSW) of the UN. The guiding research question for my project is ″How is gender equality policy socially constructed in UN’s CSW?″ My goal is to unpack some of the processes and politics of knowledge and norm-production in the CSW in order to explore ways in which women and men around the world may be better able to shape and influence global gender equality policy and utilize it in their national contexts. -
Transgender Identity and Cryptorchidism: a Case Study
ORIGINAL ARTICLE Volume 42, Issue 1, January-February 2019 doi: 10.17711/SM.0185-3325.2019.007 Transgender identity and cryptorchidism: A case study Tania Real Quintanar,1 Rebeca Robles García,1 María Elena Medina-Mora,1 Juan Carlos Jorge,2 Lucía Vázquez Pérez3 1 Centro de Investigación en Salud ABSTRACT Mental Global, Dirección de In- vestigaciones Epidemiológicas y There is a wide range of possible combinations in relation to sex at birth, gender identity, and Psicosociales, Instituto Nacional de Introduction. Psiquiatría Ramón de la Fuente Mu- sexual orientations. Specific medical and psychological treatment needs may also vary depending on these ñíz, Mexico City, Mexico. combinations. Objective. In order to promote interventions that focus on the perceived needs of those directly 2 Departamento de Anatomía y Neu- involved, the aim of the present case study is to describe the clinical and life experiences of a 43-year old trans- robiología, Escuela de Medicina, gender woman with cryptorchidism and examine the interplay between this relative common testicular problem Universidad de Puerto Rico, San at birth, gender identity, and sexual orientation formation processes from her own perspective. An Juan, Puerto Rico. Method. in-depth interview was conducted at a specialized care centre in Mexico City, Mexico. The interview was audio 3 Departamento de Investigaciones Epidemiológicas y Psicosociales, recorded and transcribed for a content analysis. Results. The case under analysis was assigned to the male Dirección de Investigaciones Epi- sex and identified herself as a transgender woman and lesbian. Although it is not possible to conclude that demiológicas y Psicosociales, Insti- her gender identity or sexual orientation is related to her antecedent of cryptorchidism, as she reflected on her tuto Nacional de Psiquiatría Ramón related negative experiences, she concluded that her gender identity and sexual orientation trajectories, as well de la Fuente Muñíz, Mexico City, Mexico. -
Health and Wellbeing of People with Intersex Variations Information and Resource Paper
Health and wellbeing of people with intersex variations Information and resource paper The Victorian Government acknowledges Victorian Aboriginal people as the First Peoples and Traditional Owners and Custodians of the land and water on which we rely. We acknowledge and respect that Aboriginal communities are steeped in traditions and customs built on a disciplined social and cultural order that has sustained 60,000 years of existence. We acknowledge the significant disruptions to social and cultural order and the ongoing hurt caused by colonisation. We acknowledge the ongoing leadership role of Aboriginal communities in addressing and preventing family violence and will continue to work in collaboration with First Peoples to eliminate family violence from all communities. Family Violence Support If you have experienced violence or sexual assault and require immediate or ongoing assistance, contact 1800 RESPECT (1800 737 732) to talk to a counsellor from the National Sexual Assault and Domestic Violence hotline. For confidential support and information, contact Safe Steps’ 24/7 family violence response line on 1800 015 188. If you are concerned for your safety or that of someone else, please contact the police in your state or territory, or call 000 for emergency assistance. To receive this publication in an accessible format, email the Diversity unit <[email protected]> Authorised and published by the Victorian Government, 1 Treasury Place, Melbourne. © State of Victoria, Department of Health and Human Services, March 2019 Victorian Department of Health and Human Services (2018) Health and wellbeing of people with intersex variations: information and resource paper. Initially prepared by T. -
How Could the Yogyakarta Principles Help Improve the Situation Of
How could the Yogyakarta Principles help improve the situation of transgender people, when examined in the framework of existing bodies of international non-discrimination norms? Alexandra PISA, ANR 835165 University of Tilburg International and European Public Law, Human Rights Track Supervising professors: S.J. Rombouts Stefanie Jansen 1 Table of contents Introduction............................................................................................................................................... .1 1. Chapter I – A general view of the 'Yogyakarta Principles' …............................................................... 1 1. What are the Yogyakarta Principles and what is their role?........................................................... 3 2. What is their legal status?.............................................................................................................. 4 3. What do the principles contain?..................................................................................................... 6 4. How were the Principles received by the international community?................................................................................................................................... 8 2. Chapter II – Comparing the Principles with existing international legal norms.................................. 13 1. Are the 'Yogyakarta Principles' derived from existing international legal norms?......................................................................................................................................... -
Individualized Treatment Guidelines for Postpubertal Cryptorchidism
pISSN: 2287-4208 / eISSN: 2287-4690 World J Mens Health 2015 December 33(3): 161-166 http://dx.doi.org/10.5534/wjmh.2015.33.3.161 Review Article Individualized Treatment Guidelines for Postpubertal Cryptorchidism Jae Min Chung1,2, Sang Don Lee1,2 1Department of Urology, Pusan National University School of Medicine, 2Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea Cryptorchidism is a well-known congenital anomaly in children. However, its diagnosis is often delayed for reasons including patient unawareness or denial of abnormal findings in the testis. Moreover, it has been difficult to establish an optimal treatment strategy for postpubertal cryptorchidism, given the small number of patients. Unlike cryptorchidism in children, postpubertal cryptorchidism is associated with an increased probability of neoplasms, which has led orchiectomy to be the recommended treatment. However, routine orchiectomy should be avoided in some cases due to quality-of-life issues and the potential risk of perioperative mortality. Based on a literature review, this study proposes individualized treatment guidelines for postpubertal cryptorchidism. Key Words: Adolescent; Adult; Cryptorchidism INTRODUCTION egies for cryptorchidism in children are well-established. A surgical approach, most often orchiopexy, is recom- Cryptorchidism is a pathological condition in which the mended for testes that remain undescended after six testis fails to descend to the base of the scrotum. It is one months of age [3]. However, it has been difficult to estab- of the most common congenital anomalies encountered in lish a standard treatment for postpubertal cryptorchidism, pediatric urology. Despite extensive study, knowledge re- given the small number of patients with this condition. -
CRYPTORCHIDISM Patrick M. Mccue DVM, Phd, Diplomate American College of Theriogenologists
CRYPTORCHIDISM Patrick M. McCue DVM, PhD, Diplomate American College of Theriogenologists A horse is considered to be a cryptorchid to enter the scrotum in horses up to 2 to 3 (also known as a rig or ridgling) if one or years of age. both testes are not fully descended into the scrotum. Cryptorchid testes may be located Cryptorchid testes are incapable of under the skin outside of the inguinal canal, producing sperm due to the elevated within the inguinal canal or inside of the temperature of the retained testes. abdominal cavity. A horses with testes Consequently, a stallion would be sterile if located in the inguinal area outside of the both testes are cryptorchid. Stallions with body cavity is commonly known as a ‘high one retained testis and one scrotal testis are flanker’. usually fertile since an adequate number of motile sperm are produced by the descended Cryptorchidism in the horse can occur with testis to get mares pregnant. Libido and either the left or right testis or with both aggressive male behavior is present in testes. Failure of one or both testes to cryptorchid stallions since testosterone is descend into the scrotum may be due to still produced by the retained testes. As genetic predisposition, insufficient androgen shown in the photo below taken after (i.e. testosterone) stimulation, and other surgical removal of both testes, a factors. A genetic or heritable basis for the cryptorchid testis (right) is usually cryptorchid trait has been identified in the significantly smaller than the normal scrotal pedigrees of certain stallions. However, in testis. -
Hypotonia, Mental Retardation, Obesity, and Cryptorchidism Associated with Dwarfism and Diabetes in Children
Arch. Dis. Childh., 1967, 42, 126. Arch Dis Child: first published as 10.1136/adc.42.222.126 on 1 April 1967. Downloaded from Hypotonia, Mental Retardation, Obesity, and Cryptorchidism Associated with Dwarfism and Diabetes in Children BERNARD M. LAURANCE From the Derbyshire Children's Hospital, Derby The baby who is 'floppy' at birth invariably poses had had an incomplete abortion in 1949 and a left a diagnostic problem, but over the past few years salpingo-oophorectomy in 1950. Her blood group was new descriptions of associated clinical patterns have A rhesus positive with anti-A agglutinins. After birth differentiated certain groups of disorders. One he was lethargic, cried, and sucked feebly, and limb such movements were slight; colour and general appearance group, only recognized during the past ten were normal; tendon reflexes were absent; anterior years, is presented here. fontanelle, sutures, and fundi were normal; cephalhae- In 1956 some Swiss children were described: all matoma was present. Scrotum was poorly developed; were floppy at birth, had a similar facial appearance testicles were impalpable, and the penis was very small. and later became obese, dwarfed, and mentally Subdural taps were dry. After two weeks of tube- retarded (Prader, Labhart, Willi, and Fanconi, feeding, he suckled from the breast a little, but a fort- 1956b). There were both boys and girls in this night later was readmitted because of failure to thrive, and because generalized hypotonia persisted. Cerebro- group, but the boys had the additional feature of copyright. poorly developed genitalia. Some of the children spinal fluid (CSF) was normal and repeat subdural taps were dry. -
How Trans People Simultaneously Challenge and Reproduce
Complicating Normal: How Trans People Simultaneously Challenge and Reproduce Heteronormativity A thesis presented to the faculty of the College of Arts and Sciences of Ohio University Master of Arts Katherine M. Kassner August 2010 © 2010 Katherine M. Kassner. All Rights Reserved. 2 This thesis titled Complicating Normal: How Trans People Simultaneously Challenge and Reproduce Heteronormativity By KATHERINE M. KASSNER has been approved for the Department of Sociology and Anthropology and the College of Arts and Sciences by ________________________________________ Cynthia D. Anderson Associate Professor of Sociology and Anthropology ________________________________________ Benjamin M. Ogles Dean, College of Arts and Sciences 3 ABSTRACT KASSNER, KATHERINE M., M.A., August 2010, Sociology Complicating Normal: How Trans People Simultaneously Challenge and Reproduce Heteronormativity (84 pp.) Director of Thesis: Cynthia D. Anderson This thesis examines the interactions between trans people and structural heteronormativity. Twenty-five in-depth interviews were conducted with self-identified trans people to assess how interviewees feel they’ve been affected by structural heteronormativity across the institutions of marriage, family, healthcare, education, and work. Interview questions further examined whether interviewees feel they challenge or reproduce structural heteronormativity. Analytic induction was used to analyze the interview data. Results demonstrate that all interviewees identify that they challenge structural heteronormativity and slightly more than half of interviewees identify that they reproduce structural heteronormativity. However, further analysis of the data suggests that some interviewees may challenge or reproduce heteronormativity at an individual level and had no effect or sometimes the opposite effect at the structural level. These findings were highly dependent on whether interviewees identify themselves as out or stealth as a trans person. -
Tracing Social and Legal Acceptance of the Transgender Community in Developing Countries
CONCEPT, Vol. XXXIX (2016) 1 Third Gender and the Third World: Tracing Social and Legal Acceptance of the Transgender Community in Developing Countries Kimberly Tower Political Science Introduction There is a stereotype in the Global North that asserts its superiority over its less developed neighbors in the South.1 This idea goes beyond technology, economics, education, and health care. Some believe that the Global North is morally more advanced and treats its citizens in a more equal manner. By extension, Global South countries are generalized as “backwards, traditional, [and] oppressive.”2,3 Upon closer examination, this holds no water. There is an “immense variation” in human rights in the developing world that is just as wide-ranging as their “different religious, historical, political and cultural practices.”4 Actually, many of these states are quantifiably more progressive than the West on certain issues. This is particularly true in terms of transgender rights. While the United States is still struggling with the question of which bathrooms transgender people should use, Tehran is one of the global capitals of sex reassignment surgery.56 Some countries have gone so far as to create laws requiring insurance companies to cover medical costs, something that is not even up for debate in many US states (see Table II). 1 Formerly known as the “First World” and “Third World,” respectively, the Global North/South distinction represents the social, economic, and political differences that exist between developed and developing states. 2 La Barbera, Maria Caterina. Identity and Migration in Europe: Multidisciplinary Perspectives. (Dodrecht: Springer, 2015), p. 61. 3 Lambino, Antonio.