The MLL Recombinome of Acute Leukemias in 2017
OPEN Leukemia (2018) 32, 273–284 www.nature.com/leu ORIGINAL ARTICLE The MLL recombinome of acute leukemias in 2017 C Meyer1, T Burmeister2, D Gröger2, G Tsaur3, L Fechina3, A Renneville4, R Sutton5, NC Venn5, M Emerenciano6, MS Pombo-de-Oliveira6, C Barbieri Blunck6, B Almeida Lopes6, J Zuna7,JTrka7, P Ballerini8, H Lapillonne8, M De Braekeleer9,{, G Cazzaniga10, L Corral Abascal10, VHJ van der Velden11, E Delabesse12, TS Park13,SHOh14, MLM Silva15, T Lund-Aho16, V Juvonen17, AS Moore18, O Heidenreich19, J Vormoor20, E Zerkalenkova21, Y Olshanskaya21, C Bueno22,23,24, P Menendez22,23,24, A Teigler-Schlegel25, U zur Stadt26, J Lentes27, G Göhring27, A Kustanovich28, O Aleinikova28, BW Schäfer29, S Kubetzko29, HO Madsen30, B Gruhn31, X Duarte32, P Gameiro33, E Lippert34, A Bidet34, JM Cayuela35, E Clappier35, CN Alonso36, CM Zwaan37, MM van den Heuvel-Eibrink37, S Izraeli38,39, L Trakhtenbrot38,39, P Archer40, J Hancock40, A Möricke41, J Alten41, M Schrappe41, M Stanulla42, S Strehl43, A Attarbaschi43, M Dworzak43, OA Haas43, R Panzer-Grümayer43, L Sedék44, T Szczepański45, A Caye46, L Suarez46, H Cavé46 and R Marschalek1 Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene.
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