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Antazoline Hydrochloride

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Antazoline Hydrochloride Antazoline hydrochloride sc-203515 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Antazoline hydrochloride STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH2 HAZARD INSTABILITY0 SUPPLIER Company: Santa Cruz Biotechnology, Inc. Address: 2145 Delaware Ave Santa Cruz, CA 95060 Telephone: 800.457.3801 or 831.457.3800 Emergency Tel: CHEMWATCH: From within the US and Canada: 877-715-9305 Emergency Tel: From outside the US and Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 PRODUCT USE ■ CAUTION: Antihistamines may cause drowsiness and dulling of mental alertness. Patients undergoing treatment with these drugs should not take charge of a vehicle, other means of transportation or machinery where loss of attention may lead to an accident. Patients should abstain from alcohol. Antihistamine. Imidazoline agonist; more potent than efaroxan in inducing insulin release from beta-cells; H1 antagonist. Antazoline is an ethylenediamine derivative. The sulfate and phosphate are used locally with a vasoconstrictor such as naphazoline nitrate or xylometazoline hydrochloride, in nasal drops and eye-drops for nasal and ocular allergies. SYNONYMS C17-H19-N3.HCl, "2-(N-benzylanilinomethyl)-2-imidazoline hydrochloride", "2-(N-benzylanilinomethyl)-2-imidazoline hydrochloride", "2-imidazoline, 2-[(N-benzylanilino)methyl]-, monohydrochloride", "2-imidazoline, 2-[(N-benzylanilino)methyl]-, monohydrochloride", "phenazoline hydrochloride", "2-phenylbenzylaminomethylimidazoline hydrochloride", "2- phenylbenzylaminomethylimidazoline hydrochloride", "2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride", "2-(N- phenyl-N-benzylaminomethyl)imidazoline hydrochloride", "Antistine hydrochloride", Fenazolina, Histazine, "imidazoline agonist", "H1 antagonist", antihistamine Section 2 - HAZARDS IDENTIFICATION CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ■ Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. ■ Antihistamines have side effects such as sedation, stomach upset (nausea, vomiting, diarrhea or constipation), blurred vision, ringing in the ears, mood changes, irritability, nightmares, loss of appetite, difficulty urinating, dry mouth, chest tightness and tingling, heaviness and weakness in the hands, nervousness, restlessness, irritability, feeling of well-being, disturbed eye movements, difficulties moving the face, "pins and needles", palpitations, faintness, increased heart rate, uncommonly irregular heart rhythms, lung swelling, and disturbed sleep and dreaming. Treatment may cause side effects within 15 minutes including a dry mouth and throat, blocked nose, wheeze, thick phlegm, fever, sweating, smell disturbances, skin flushing, double vision and dilated pupils. Central nervous system depression may cause drowsiness, dizziness, lethargy, fatigue, loss of alertness and concentration, inco-ordination, absence of breathing, stupor and coma. Sometimes stimulation occurs after depression, and causes excitement, anxiety, jerky eye movements, involuntary movements of extremities, tremors, hallucinations, delirium, psychosis, and convulsions. There may be a characteristic spastic posture or loss of tone, inability to sit still with jerking, and parkinsons-like shaking. Allergy-like symptoms with skin reactions can occur in 6-12 hours. EYE ■ This material can cause eye irritation and damage in some persons. SKIN ■ Skin contact with the material may be harmful; systemic effects may resultfollowing absorption. ■ This material can cause inflammation of the skin oncontact in some persons. ■ The material may accentuate any pre-existing dermatitis condition. ■ Open cuts, abraded or irritated skin should not be exposed to this material. ■ Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ■ Inhalation of dusts, generated by the material, during the course of normalhandling, may be harmful. ■ The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. ■ Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. CHRONIC HEALTH EFFECTS ■ Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Long-term use of antihistamines can cause sugar in the urine, obstructive jaundice, skin discoloration associated with loss of platelets, early periods, loss of milk production, breast development in males and decreased sex drive. Disturbances in the blood include anemia, loss of white blood cells and platelets. Allergic reactions include fever, eczema, red wheal and blistering, a measles-like or scarlet-fever like rash, itching, sensitivity to light, swelling of the extremities, throat and other areas, asthma, lupus-like symptoms and anaphylactic shock. Prolonged use may cause difficulty in moving the muscles of the face. Withdrawing the drug generally improves these effects. Wide area external application of antihistamines can cause various side effects, including sensitization and eczema. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS HAZARD RATINGS Min Max Flammability: 1 Toxicity: 2 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 2 Extreme=4 NAME CAS RN % antazoline hydrochloride 2508-72-7 >98 Section 4 - FIRST AID MEASURES SWALLOWED ■ IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. Where Medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise: For advice, contact a Poisons Information Center or a doctor. Urgent hospital treatment is likely to be needed. If conscious, give water to drink. INDUCE vomiting with fingers down the back of the throat, ONLY IF CONSCIOUS. Lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. NOTE: Wear a protective glove when inducing vomiting by mechanical means. In the mean time, qualified first-aid personnel should treat the patient following observation and employing supportive measures as indicated by the patient's condition. If the services of a medical officer or medical doctor are readily available, the patient should be placed in his/her care and a copy of the MSDS should be provided. Further action will be the responsibility of the medical specialist. If medical attention is not available on the worksite or surroundings send the patient to a hospital together with a copy of the MSDS. EYE ■ If this product comes in contact with the eyes: Wash out immediately with fresh running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. If pain persists or recurs seek medical attention. Removal of contact lenses after an eye injury should only be undertaken by skilled personnel. SKIN ■ If skin contact occurs: Immediately remove all contaminated clothing, including footwear Flush skin and hair with running water (and soap if available). Seek medical attention in event of irritation. INHALED ■ If fumes or combustion products are inhaled remove from contaminated area. Lay patient down. Keep warm and rested. Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures. Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary. Transport to hospital, or doctor, without delay. NOTES TO PHYSICIAN ■ In severe overdose of antihistamines, the stomach should be emptied by aspiration and lavage. Emetics should not be used. The patient should be kept quiet to minimize excitement. Convulsions should be controlled with intravenous diazepam. Forced diuresis is of little value since antihistamines are rapidly metabolized and only a trace is recovered in the urine. MARTINDALE: The Extra Pharmacopoeia; 28th Edition. Section 5 - FIRE FIGHTING MEASURES Vapour Pressure (mmHG): Negligible Upper Explosive Limit (%): Not available. Specific Gravity (water=1): Not available Lower Explosive Limit (%): Not available EXTINGUISHING MEDIA ■ Water spray
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