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Diplomas and Awards 1988 Bachelor of Biology, University of Patras 1989 Erasmus Fellowship for Post-Graduate Studies in Compiegne, France

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Diplomas and Awards 1988 Bachelor of Biology, University of Patras 1989 Erasmus Fellowship for Post-Graduate Studies in Compiegne, France GEORGE V.Z DEDOUSSIS, PHD DATE AND PLACE OF BIRTH: 25TH OF MAY 1966 IN ATHENS PROFESSOR OF HUMAN MOLECULAR GENETICS NATIONALITY: GREEK DEPARTMENT OF NUTRITION AND DIETETICS, HAROKOPIO UNIVERSITY, 70 EL. VENIZELOU STR, 17671 KALLITHEA –ATHENS, TEL: 0030-210-9549304, CELL: 0030-6973536730, EMAIL: [email protected] Diplomas and Awards 1988 Bachelor of Biology, University of Patras 1989 Erasmus fellowship for post-graduate studies in Compiegne, France. 1990 D.E.A of Biotechnology, Microbiology et Bioconversion, University of Compiegne, France. Title of research project: “Production of human monoclonal antibodies against tumor antigens in breast cancer”, Compiegne, France 1990-1994 Participation in the EEC program “Production of Monoclonal Antibodies against cancer” Saint Savas Anticancer Hospital of Athens 1995 PhD Thesis. “Phenotypic and functional characterization of tumor infiltrating lymphocytes in breast cancer”. Medical School of Athens. 1996-1998 Post-Doctoral research in the laboratory of Molecular Biology in the Center of Thalassaemia in Athens. Participation in the EEC program EPET I “Development of new biotechnological approaches for the diagnosis and therapy of genetic disorders. 2004 Fulbright Fellow for three months at Harvard Medical School, Department of Genetics, Boston 2010-today Guest Editor in Genetics: Current Nutrition Reports 2009-today Grant reviewer for the Greek General Secretary of Research and Technology GREECE, Institute National de la santé et de la recherché medicale, 101. Rue de Tolbiac, 75654 Paris Cedex 13, FRANCE, Romanian National Council for Scientific Research, Schitu Magureanu Blvd, 3rd floor, 5th sector, 050025 Bucharest, Romania. 2000-today Grants awarded from National funding, private sector and European Union, in total >4.000.000 Euros. 2018 Among the higly cited scientists for the last decade Professional situation 1990-1994 Participation in the EEC program “Production of Monoclonal Antibodies against cancer” Saint Savas Anticancer Hospital of Athens 1991=2000 Lecturer at the Department of Psychology, University of Rouen, and the Department of Sociology, University of Strasburg, France in collaboration with the Francophone college (CFES) 2000-2004 Lecturer of Molecular Biology 2004-2008 Assistant Professor of Human Cellular and Molecular Biology 1 2009-2013 Associate Professor of Human Cellular and Molecular Biology 2013-today Full Professor Administration assignements Institutional coordinator of the Erasmus program (2011-2018) Board Member of the University Council (2012-2016) Member of the National Research and Innovation Council (2016-2020) Director of the Laboratory of Biology/Biochemistry/Microbiology/Physiology (2017-2020) Invited speaker in international meetings 1. 8th International Seminar of the Greek Institute of Osteoporosis, Athens, November 2003. Speaker in roundtable on "The role of genetics in the pathogenesis of osteoporosis." 2. Biologie Prospective - Santorini Conference 2004 From Human Genetic Variations to Prediction of Risks and Responses to the Environment. 3. ESPT (European Society of Pharmacogenetics and Theranostics) Summer School, Lyublyana 2012. Two lectures: Introduction to Human Genetics, Nutrigenetics/Nutrigenomics. 4. 6th Santorini Conference Biology Prospective “Systems Biology and Personalised Health Science and Translation” Title of Lecture: Gene Environment Interactions, Santorini, 30/09-02/10/2012. 5. 3rd congress of the European Society of Preventive Medicine (EUSPM), Riolo Terme, Italy, 9-10 March, 2013. Title of Lecture: Genetic predisposition of childhood obesity. The impact of nutrition. 6. EASD NAFLD Study Group Meeting NewCastle, 11th-12th May 2015. The Hellenique NAFLD study. Genetics and Lifestyle determinants. Nutritional intervention with Corinthian raisins. 7. 7th Santorini Conference Biology Prospective “Systems Biology and Personalised Health Science and Translation” Title of Lecture: Non-alcoholic fatty liver disease. Genetic etiology and nutritional intervention, Santorini, 25-27/9/2014. 8. 8th Santorini Conference: Systems Medicine and Personalized Health and Therapy, Title of Lecture: Nutritional interventions in Non-alcoholic fatty liver disease. The MAST4HEALTH program. Santorini, Greece, 3-5 October 2016. Visiting Professor abroad [1] Visiting Professor, (2004, 2007, 2009, 2010, 2018), at INSERM U525 Equipe 4, Faculté de Pharmacie - UHP Nancy 1 (Director: Professor Gérard SIEST), 30 rue Lionnois - 54000 NANCY – France. [2] Visiting Professor at the University of Tartu, Estonia, under the auspices of bilateral collaborations Greece-Estonia, 6/2006. Academic duties 2 Supervisor of the following PhD thesis 1) Mutation analysis in Familial Hypercholesterolemia patients of Greek and German origin. (Status: completed). 2) Mutation analysis of SLC3A1 and SLC7A9 genes in Greek patients with cystinuria. (Status: completed). 3) Interactions of genes, nutrition and lifestyle determinants in ageing people. (Status: completed). 4) Interactions of genetic and nutrition determinants in childhood obesity. (Status: completed). 5) Dietary patterns and genetic predisposition on phenotypes associated with cardiovascular disease. (Status: completed). 6) Cardiometabolic indices in isolated cohorts: Genetic predisposition and environmental modifiers. (Status: completed). 7) Genomics in extreme obesity. (Status: in progress, expected to defend soon). 8) Interactions of genetic variants with lifestyle determinants in bone metabolism indices. (Status: expected to defend soon). 9) Non alcoholic fatty liver disease. Genetic aetiology and interactions with dietary factots. (Status: completed). 10) Functional Biology in cardiovascular disease. (Status: in progress). 11) Design of prognostic computational tools in Non-Alcoholic Fatty Liver Disease. (Status: in progress). Research Grants awarded (>4,000,000 Euros) Project acronym Title Funding Agency Duration Budget (Euros) (years) PAVET 2000 Methods for the analysis Secretary of research 2 255.320 (coordinator) recording and saving of genetic and innovation of data in Familial Greek ministry (GSRT) Hypercholesterolemia (FH) IKYDA 2001 Mutation analysis of LDL-R gene in IKY 2 15.000 (coordinator) Greek and German patients with FH. Private Association of CTR genotype with Novartis 1 5.000 (coordinator) responsiveness to therapy with calcitonin in meta-menopausal females with osteoporosis. PENED 2003 Study of polymorphisms in GSRT 3 67.500 (coordinator) endothelium inflammation. Dietary determinatns as modifiers in gene expression in cardiovascular disease. ZINCAGE Nutritional zinc, oxidative stress FP6-FOOD 3 115.000 (partner) and immunosenescence: European Community biochemical, genetic and lifestyle implications for healthy ageing EUGINDAT European Genomics Initiative on FP6-2002- 3 25.000 (partner) Disorders of Plasma membrane LIFESCIHEALTH Amino acid Transporters GENDAI Gene nutrient interactions in Coca Cola 2 100.000 (coordinator) childhood obesity 3 WilsonIndia Novel opportunities for diagnosis FP7-PEOPLE-2009- 3 7.500 (partner) and therapy of Wilson’s disease in IRSES. Marie Curie India Androgenetic Genetic predisposition of DHI Global Medical 1 11.800 Alopecia androgenetic alopecia Group (coordinator) HELIC Study of cardiometabolic indices Wellcome Trust 2 147.000 (co-coordinator) in Hellenic Isolated Cohorts Sanger Institute HRAKLEITOS ΙΙ Gene-dietary patterns Ministry of Education 3 38.750 (coordinator) interactions in childhood obesity and religion affairs Cooperation 2011 Obesity and metabolic syndrom: GSRT 3 245.000 (partner) Nutritional intervention with Corinthian raisins in NAFLD/ NASH patients. Exploration of molecular mechanisms. Erasmus 2011-16 Placements of Harokopio ΙΚΥ 4 350.000 (coordinator) University students and staff members THALIS Genomic study in morbid obesity. Ministry of Education 3 585.000 (coordinator) Genetic risk varinats, the role of and religion affairs nutrition and the lifgestyle. Marie-Curie RISE Mastiha treatment for healthy EU 4 2.124.000 (coordinator) obese with NAFLD diagnosis (MAST4HEALTH). 4 ACADEMIC SCORING Citations h-factor Total impact factor Mean impact factor Publications >45000 70 >6000 21 275 Publications (15 out of 275) 1. Giri A, Hellwege JN, Keaton JM, ...Dedoussis G,... Edwards TL. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet. 2019 Jan;51(1):51-62. doi: 10.1038/s41588-018-0303-9. 2. Gilly A, Southam L, Suveges D, Kuchenbaecker K, Moore R, Melloni GEM, Hatzikotoulas K, Farmaki AE, Ritchie G, Schwartzentruber J, Danecek P, Kilian B, Pollard MO, Ge X, Tsafantakis E, Dedoussis G, Zeggini E. Very low depth whole genome sequencing in complex trait association studies. Bioinformatics. 2018 Dec 21. doi: 10.1093/bioinformatics/bty1032. 5 3. Hackinger S, Prins B, Mamakou V, Zengini E, Marouli E, Brčić L, Serafetinidis I, Lamnissou K, Kontaxakis V, Dedoussis G, Gonidakis F, Thanopoulou A, Tentolouris N, Tsezou A, Zeggini E. Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. Transl Psychiatry. 2018 Nov 23;8(1):252. doi: 10.1038/s41398-018-0304-6. 4. Gilly A, Suveges D, Kuchenbaecker K, Pollard M, Southam L, Hatzikotoulas K, Farmaki AE, Bjornland T, Waples R, Appel EVR, Casalone E, Melloni G, Kilian B, Rayner NW, Ntalla I, Kundu K, Walter K, Danesh J, Butterworth A, Barroso I, Tsafantakis E, Dedoussis G, Moltke I, Zeggini E. Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits. Nat Commun. 2018 Nov 7;9(1):4674. doi: 10.1038/s41467-018-07070-8.
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