TYPE 2 DIABETES Diabetesmanagementnc.Com in NORTH CAROLINA Fact Sheet
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Living with Diabetes in the Family Iabetes Affects All Members of the Family, Fat Diet and the Twice-Daily Insulin Injections
SA JOURNAL OF DIABETES & VASCULAR DISEASE REVIEW References 10. Hattersley A, Bruining J, Shield J, Njolstad P, Donaghue KC. The diagnosis of and management of monogenic diabetes in children and adolescents. Pediat Diabetes 1. Neel J. Diabetes mellitus: a geneticist’s nightmare. In: Creutzfeldt W, Kobberling 2009; 10(suppl 12): 33–42. J, Neel JV, eds. The Genetics of Diabetes Mellitus. Berlin: Springer-Verlag, 1976: 11. Slingerland AS. Monogenic diabetes in children and adults: Challenges for 1–11. researcher, clinician and patient. Rev Endocr Metab Disord 2006; 7: 171–185. 2. Keen H. The genetics of diabetes: from nightmare to headache. Br Med J 1987; 12. Barrett TG. Differential diagnosis of type 1 diabetes: which genetic syndromes 294: 917–919. need to be considered? Pediat Diabetes 2007; 8(suppl 6): 15–23. 3. Rotter JI. The modes of inheritance of insulin-dependent diabetes mellitus or the 13. Clinical genetics and genetic counseling. In: Jorde LB, et al., eds. Medical genetics of IDDM, no longer a nightmare but still a headache. Am J Hum Genet Genetics, 2nd edn. St Louis: Mosby, 1999: 292. 1981; 33: 835–851. 14. The National Society of Genetic Counselor’s Task Force: Resta R, et al. A new 4. Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification definition of genetic counselling: National Society of Genetic Counselor’s Task of diabetes in children and adolescents. Pediat Diabetes 2009; 10(suppl 12): 3–12 Force report. J Genet Couns 2006; 15(2): 77–83. 5. Jahromi MM, Eisenbarth GS. Cellular and molecular pathogenesis of type 1A 15. -
Glossary of Common Diabetes Terms
Glossary of Common Diabetes Terms A1C: a test that reveals exactly how well your blood sugar (glucose) has been controlled over the previous three months Beta cells: cells found in the pancreas that make insulin Blood glucose: also known as blood sugar, glucose comes from food and is then carried through the blood to deliver energy to cells Blood glucose meter: a small medical device used to check blood glucose levels Blood glucose monitoring: the simple blood test used to check the amount of glucose in the blood; a tiny drop of blood, taken by pricking a finger, is placed on a test strip and inserted in the meter for reading Diabetes: the shortened name for diabetes mellitus, the condition in which the pancreas doesn’t produce enough insulin or your body is unable to use insulin to move glucose into cells of the body Diabetic retinopathy: the eye disease that occurs in someone with diabetes when the small blood vessels of the retina become swollen and leak liquid into the retina, blurring vision; it can sometimes lead to blindness Gestational diabetes: the diabetes some women develop during pregnancy; it typically subsides after the baby is delivered, but many women who have had gestational diabetes may develop type 2 diabetes later in life Glucagon: the hormone that is injected into a person with diabetes to raise their blood glucose level when it’s very low (hypoglycemia) Glucose: blood sugar that gives energy to cells Hyperglycemia: also known as high blood glucose, this condition occurs when your blood glucose level is too high; -
Food Fact Sheet
Food Fact Sheet Diabetes - Type 2 What is Type 2 diabetes? Diabetes is a condition where the amount of glucose (sugar) in your blood is too high because your body cannot use it properly. In Type 2 diabetes this happens because your pancreas doesn’t produce enough of the hormome insulin (that helps glucose enter body cells) and/or the insulin that is produced does not work correctly (insulin resistance). The importance of good blood glucose control 2 Reduce your portion sizes to help you reduce and People with Type 2 diabetes need to control their maintain a healthy weight. blood glucose. It is also important to look after your A portion is: heart health. Making changes to your lifestyle, diet and • a fist size of potatoes, bread, pasta or other activity level can be key to reducing the risk of diabetes starchy carbohydrates causing you problems now and in the future. • a palm size of meat/fish or poultry What can you eat? • two handfuls of vegetables or salad • a cupped-handful of fruit People with diabetes should eat a healthy diet, the • top of your thumb size of oil or fat spread. same as somebody without diabetes. It should be low Try using a smaller plate, filling half of your plate with in saturated fat, high in fibre and include a variety of vegetables and avoiding second helpings. fruit and vegetables. 3 Carbohydrates are used for energy so include some The eatwell guide in your diet each day. Opt for wholegrain options, fruits and vegetables, beans, pulses, low fat milk and The eatwell guide represents the main food groups and yoghurt. -
Diabetic Coma
University of Nebraska Medical Center DigitalCommons@UNMC MD Theses Special Collections 5-1-1932 Diabetic coma J. Milton Margolin University of Nebraska Medical Center This manuscript is historical in nature and may not reflect current medical research and practice. Search PubMed for current research. Follow this and additional works at: https://digitalcommons.unmc.edu/mdtheses Part of the Medical Education Commons Recommended Citation Margolin, J. Milton, "Diabetic coma" (1932). MD Theses. 218. https://digitalcommons.unmc.edu/mdtheses/218 This Thesis is brought to you for free and open access by the Special Collections at DigitalCommons@UNMC. It has been accepted for inclusion in MD Theses by an authorized administrator of DigitalCommons@UNMC. For more information, please contact [email protected]. DIAB3TIC COMA J. MIJ/rON 1l1LARGOLIN THE illnVERSITY OF NlsBRASKA COLLEGE OF ~~DICINE -- OMAHA, NEBHASKA 1932 - DIAB3TIG COl£.<\ Diabetic coma is a true medical emergency. It is just as much an emergency as an acute appendicitis or an incarcerated hernia, and as in the latter condition, with every hour that passes without treatment the chances for life decrease. It is early intervention that counts. Therefore, a physician should never let an engagement or any personal desires keep him from the bedside of a patient whom he thinks may be in coma. HISTORY Diabetic coma has been known as a clinical entity since l8bO when a German, Von Dusch and a Scotchman, March firs t de scri bed it. 'l'wen ty years later, Kus smaul publ i shed his classical description of diabetic coma. It is the IlKussmaul breathing, II as described by the author which is the outstanding and characteristic feature of diabetic coma. -
Comparative Evaluation of Fructosamine and Hba1c As a Marker of Glycemic Control in Type 2 Diabetes: a Hospital Based Study
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Comparative Evaluation of Fructosamine and HbA1c as a Marker of Glycemic Control in Type 2 Diabetes: A Hospital Based Study Dr. Jyoti Goyal1, Dr. Nibhriti Das2, Dr. Navin Kumar3, Ms. Seema Raghav4, Dr. Paramjeet Singh Bhatia5, Dr. Karunesh Prasad Singh6, Dr. Sabari Das7 1DNB, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India- 281003, 2Ex-Director of Laboratory services and Additional Dean Research and Academics, Nayati Healthcare and Research Centre, Mathura, India- 281003, 3Ph.D, Biostatistitian, Department of Biostatistics, Nayati Healthcare and Research Centre, Mathura, India-281003. 4M.Sc., Certified Diabetes Educator, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003. 5MD, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003. 6MD Physician, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003. 7Department of Laboratory Medicine, Nayati Healthcare and Research Centre, Mathura, India- 281003, Corresponding Author: Dr. Jyoti Goyal ABSTRACT Introduction: Management of type 2 diabetes revolves around achievement of target glycemic control with the help of antidiabetic drugs or insulin. There are various markers for measurement of glyceamic control like HbA1c, Mean Blood Glucose and fructosamine levels. Though HbA1c is a well validated standard method for assessment of glycemic control but it has also got certain limitations. Fructosamine, a less explored method may be used as an alternative marker for an assessment of glycemic control in cases where HbA1c is unreliable or unavailable. The objective of this study is to compare the fructosamine levels with HbA1c in assessment of glycemic control in type 2 diabetics so as to assess the utility of fructosamine as an alternative marker for evaluation of glucose control. -
Diabetes Is a Disease in Which the Body's Ability to Produce Or Respond
Early Signs and Symptoms of diabetes: Early symptoms of diabetes, especially type 2 diabetes, can be subtle or seemingly harmless. Over time, however, you may Diabetes is a disease in which the develop diabetes complications, even if you body’s ability to produce or respond to haven't had diabetes symptoms. In the the hormone insulin is impaired, United States alone, more than 8 million resulting in abnormal metabolism of people have undiagnosed diabetes, Treatments: carbohydrates and elevated levels of according to the American Diabetes Association. Understanding possible glucose (sugar) in the blood. • Insulin therapy diabetes symptoms can lead to early • Oral medications diagnosis and treatment and a lifetime of Diabetes can be broken down into • better health. If you're experiencing any of Diet changes two types, Type 1 and Type 2. Type 1 • Exercise diabetes involves the the following diabetes signs and symptoms, see your doctor. body attacking itself by The medications you take vary by mistake, this then the type of diabetes and how well the causes the body to stop making insulin. With medicine controls you blood glucose levels. Type 2 diabetes the Type 1 diabetics must have insulin. Type 2 body does not respond may or may not include insulin and may just like it should to the be controlled with diet and exercise alone. insulin the pancreas is If you notice any of these changes notify making. Your body tells the pancreas that it needs to make more insulin since the your health care provider. The earlier • insulin that is already there is not working. -
Prediabetes: What Is It and What Can I Do?
Prediabetes: What Is It and What Can I Do? What is prediabetes? Weight loss can delay or prevent diabetes. Prediabetes is a condition that comes before Reaching a healthy weight can help you a lot. diabetes. It means your blood glucose levels are If you’re overweight, any weight loss, even higher than normal but aren’t high enough to be 7 percent of your weight (for example, losing called diabetes. about 15 pounds if you weigh 200), may lower your risk for diabetes. There are no clear symptoms of prediabetes. You can have it and not know it. If I have prediabetes, what does it mean? It means you might get type 2 diabetes soon or down the road. You are also more likely to get heart disease or have a stroke. The good news is that you can take steps to delay or prevent type 2 diabetes. How can I delay or prevent type 2 diabetes? You may be able to delay or prevent type 2 diabetes with: Daily physical activity, such as walking. Weight loss, if needed. Losing even a few pounds will help. Medication, if your doctor prescribes it. If you have prediabetes, these steps may bring your blood glucose to a normal range. But you are still at a higher risk for type 2 diabetes. Regular physical activity can delay or prevent diabetes. Being active is one of the best ways to delay or prevent type 2 diabetes. It can also lower your weight and blood pressure, and improve cholesterol levels. Ask your health care team about activities that are safe for you. -
Low Blood Glucose (Hypoglycemia)
Low Blood Glucose (Hypoglycemia) Hypoglycemia, also known as low blood Hunger, nausea glucose (blood sugar), is when your blood Color draining from skin (pallor) glucose levels have fallen low enough that you need to take action to bring them back Feeling sleepy to your target range. This is usually when your blood glucose is less than 70 mg/dL. However, Feeling weak, having no energy talk to your doctor about your own blood Blurred/impaired vision glucose targets, and what level is too low for you. Tingling or numbness in lips, tongue, cheeks Headaches When can it happen? Coordination problems, clumsiness Low blood glucose can happen if you’ve skipped a meal or snack, eaten less than usual, or been Nightmares or crying out in sleep more physically active than usual. If you don’t Seizures take steps to bring glucose levels back to normal, you could even pass out. What should you do? What are the symptoms? The 15-15 rule—have 15 grams of carbohydrate to raise your blood glucose and check it after Each person’s reaction to low blood glucose is 15 minutes. If it’s still below 70 mg/dL, have different. It’s important that you learn your own another serving. signs and symptoms when your blood glucose is low. Repeat these steps until your blood glucose is at least 70 mg/dL. Once your blood glucose is back Signs and to normal, eat a meal or snack to make sure it symptoms of doesn’t lower again. low blood glucose include: This may be: Feeling shaky Glucose tablets (see instructions) Being nervous Gel tube (see instructions) or anxious 4 ounces (1/2 cups) of juice or regular soda Sweating, chills, (not diet) clamminess 1 tablespoon of sugar, honey, or corn syrup Mood swings, irritability, impatience 8 ounces of nonfat or 1% milk Confusion Hard candies, jellybeans, or gumdrops—see Fast heartbeat food label for how many to consume Feeling light-headed or dizzy Continued » Visit diabetes.org or call 800-DIABETES (800-342-2383) for more resources from the American Diabetes Association. -
Hyperosmolar Hyperglycemic State (HHS) Is the Most Serious Acute Hypergly- Cemic Emergency in Patients with Type 2 Diabetes
3124 Diabetes Care Volume 37, November 2014 Francisco J. Pasquel and Hyperosmolar Hyperglycemic Guillermo E. Umpierrez State: A Historic Review of the Clinical Presentation, Diagnosis, and Treatment Diabetes Care 2014;37:3124–3131 | DOI: 10.2337/dc14-0984 The hyperosmolar hyperglycemic state (HHS) is the most serious acute hypergly- cemic emergency in patients with type 2 diabetes. von Frerichs and Dreschfeld described the first cases of HHS in the 1880s in patients with an “unusual diabetic coma” characterized by severe hyperglycemia and glycosuria in the absence of Kussmaul breathing, with a fruity breath odor or positive acetone test in the urine. Current diagnostic HHS criteria include a plasma glucose level >600 mg/dL and increased effective plasma osmolality >320 mOsm/kg in the absence of ketoacidosis. The incidence of HHS is estimated to be <1% of hospital admissions of patients with diabetes. The reported mortality is between 10 and 20%, which is about 10 times higher than the mortality rate in patients with diabetic ketoacidosis (DKA). Despite the severity of this condition, no prospective, randomized studies have determined best REVIEW treatment strategies in patients with HHS, and its management has largely been extrapolated from studies of patients with DKA. There are many unresolved questions that need to be addressed in prospective clinical trials regarding the pathogenesis and treatment of pediatric and adult patients with HHS. The hyperosmolar hyperglycemic state (HHS) is a syndrome characterized by severe hyperglycemia, hyperosmolality, and dehydration in the absence of ketoacidosis. The exact incidence of HHS is not known, but it is estimated to account for ,1% of hospital admissions in patients with diabetes (1). -
Diabetic Ketoacidosis: Evaluation and Treatment DYANNE P
Diabetic Ketoacidosis: Evaluation and Treatment DYANNE P. WESTERBERG, DO, Cooper Medical School of Rowan University, Camden, New Jersey Diabetic ketoacidosis is characterized by a serum glucose level greater than 250 mg per dL, a pH less than 7.3, a serum bicarbonate level less than 18 mEq per L, an elevated serum ketone level, and dehydration. Insulin deficiency is the main precipitating factor. Diabetic ketoacidosis can occur in persons of all ages, with 14 percent of cases occurring in persons older than 70 years, 23 percent in persons 51 to 70 years of age, 27 percent in persons 30 to 50 years of age, and 36 percent in persons younger than 30 years. The case fatality rate is 1 to 5 percent. About one-third of all cases are in persons without a history of diabetes mellitus. Common symptoms include polyuria with polydipsia (98 percent), weight loss (81 percent), fatigue (62 percent), dyspnea (57 percent), vomiting (46 percent), preceding febrile illness (40 percent), abdominal pain (32 percent), and polyphagia (23 percent). Measurement of A1C, blood urea nitro- gen, creatinine, serum glucose, electrolytes, pH, and serum ketones; complete blood count; urinalysis; electrocar- diography; and calculation of anion gap and osmolar gap can differentiate diabetic ketoacidosis from hyperosmolar hyperglycemic state, gastroenteritis, starvation ketosis, and other metabolic syndromes, and can assist in diagnosing comorbid conditions. Appropriate treatment includes administering intravenous fluids and insulin, and monitoring glucose and electrolyte levels. Cerebral edema is a rare but severe complication that occurs predominantly in chil- dren. Physicians should recognize the signs of diabetic ketoacidosis for prompt diagnosis, and identify early symp- toms to prevent it. -
Postmortem Diagnosis of Diabetes Mellitus and Its Complications 183
FORENSIC SCIENCE 181 Croat Med J. 2015;56:181-93 doi: 10.3325/cmj.2015.56.181 Postmortem diagnosis of Cristian Palmiere CURML, Centre Universitaire diabetes mellitus and its Romand De Medecine Legale, Lausanne University Hospital, complications Lausanne, Switzerland Diabetes mellitus has become a major cause of death worldwide and diabetic ketoacidosis is the most common cause of death in children and adolescents with type 1 di- abetes. Acute complications of diabetes mellitus as caus- es of death may be difficult to diagnose due to missing characteristic macroscopic and microscopic findings. Bio- chemical analyses, including vitreous glucose, blood (or alternative specimen) beta-hydroxybutyrate, and blood glycated hemoglobin determination, may complement postmortem investigations and provide useful informa- tion for determining the cause of death even in corpses with advanced decompositional changes. In this article, we performed a review of the literature pertaining to the diagnostic performance of classical and novel biochemical parameters that may be used in the forensic casework to identify disorders in glucose metabolism. We also present a review focusing on the usefulness of traditional and alter- native specimens that can be sampled and subsequently analyzed to diagnose acute complications of diabetes mel- litus as causes of death. Received: March 2, 2015 Accepted: May 11, 2015 Correspondence to: Cristian Palmiere CURML, Centre Universitaire Romand De Medecine Legale Chemin de la Vulliette 4 1000 Lausanne 25, Switzerland [email protected] www.cmj.hr 182 FORENSIC SCIENCE Croat Med J. 2015;56:181-93 Diabetes mellitus has become a major cause of death of all deaths from DKA occurs in individuals with no known worldwide in people younger than 60 years. -
Diabetic Ketoacidosis Diabetic Ketoacidosis (DKA) Is a Serious Problem That Can Happen in People with Diabetes
Diabetic Ketoacidosis Diabetic ketoacidosis (DKA) is a serious problem that can happen in people with diabetes. DKA should be treated as a medical emergency. This is because it can lead to coma or death. If you have the symptoms of DKA, get medical help right away. DKA happens more often in people with type 1 diabetes. But it can happen in people with type 2 diabetes. It can also happen in women with diabetes during pregnancy (gestational diabetes). DKA happens when insulin levels are too low. Without enough insulin, sugar (glucose) can’t get to the cells of your body. The glucose stays in the blood. The liver then puts out even more glucose into the blood. This causes high blood glucose (hyperglycemia). Without glucose, your body breaks down stored fat for energy. When this happens, acids called ketones are released into the blood. This is called ketosis. High levels of ketones (ketoacidosis) can be harmful to you. Hyperglycemia and ketoacidosis can also cause serious problems in the blood and your body, such as: • Low levels of potassium (hypokalemia) and phosphate • Damage to kidneys or other organs • Coma What causes diabetic ketoacidosis? In people with diabetes, DKA is most often caused by too little insulin in the body. It is also caused by: • Poor management of diabetes • Infections such as a urinary tract infection or pneumonia • Serious health problems, such as a heart attack • Reactions to certain prescribed medicines including SGLT2 inhibitors for treating type 2 diabetes • Reactions to illegal drugs including cocaine • Disruption of insulin delivery from an insulin pump Symptoms of diabetic ketoacidosis DKA most often happens slowly over time.